LOCUS       NZ_CP059767            28402 bp    DNA     circular CON 20-SEP-2023
DEFINITION  Enterococcus faecium strain A11051 plasmid pA11051_P3, complete
            sequence.
ACCESSION   NZ_CP059767
VERSION     NZ_CP059767.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN14675381
            Assembly: GCF_012933285.2
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 28402)
  AUTHORS   Veerarghavan,B., Vasudevan,K., Arumugam,A., Solaimalai,D. and
            Bakthavatchalam,Y.D.
  TITLE     Complete genome of vancomycin resistant Enterococcus faecium
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 28402)
  AUTHORS   Veerarghavan,B., Vasudevan,K., Arumugam,A., Solaimalai,D. and
            Bakthavatchalam,Y.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2020) Clinical Microbiology, Christian Medical
            College, Ida Scudder Road, Vellore, Tamil Nadu 632004, India
REFERENCE   3  (bases 1 to 28402)
  AUTHORS   Veeraraghavan,B., Solaimalai,D., Vasudevan,K. and Arumugam,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-APR-2020) Department of Clinical Microbiology,
            Christian Medical College and Hospital, Ida Scudder Road, Vellore,
            Tamil Nadu 632004, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2020
            Assembly Method :: CANU v. v. 1.7; UNICYCLER HYBRID v. v. 0.4.6
            Assembly Name                     :: A11051
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 91.28x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 09/20/2023 03:44:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,089
            CDSs (total)                      :: 2,997
            Genes (coding)                    :: 2,835
            CDSs (with protein)               :: 2,835
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 162
            CDSs (without protein)            :: 162
            Pseudo Genes (ambiguous residues) :: 0 of 162
            Pseudo Genes (frameshifted)       :: 51 of 162
            Pseudo Genes (incomplete)         :: 102 of 162
            Pseudo Genes (internal stop)      :: 36 of 162
            Pseudo Genes (multiple problems)  :: 25 of 162
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059767.1.
            Bacteria and source DNA available from Christian Medical College.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..28402
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="A11051"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="pA11051_P3"
                     /geo_loc_name="India: Vellore"
                     /lat_lon="12.9165 N 79.1325 E"
                     /collection_date="2019"
                     /collected_by="CMC Vellore"
     gene            606..1169
                     /locus_tag="HI861_RS15060"
                     /old_locus_tag="HI861_015060"
     CDS             606..1169
                     /locus_tag="HI861_RS15060"
                     /old_locus_tag="HI861_015060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000017403.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000017403.1"
                     /translation="MSGYIYGYARVSTRSQELNRQLDLLNEQNCNEILTEKMTGTKAVR
                     PQLNRLKDKIRPGDTVIVESFSRLGRSTKDLIDLVTYFEEHHVKLVSLKENFDTSTPHG
                     RLMMTVFQAFSQFERDLIVERTKEGLKSARARGRKGGRPRVNQKDVDRAVKLYKSQVYS
                     VKEITEMTGISKATLYRYLKDNRE"
                     /name="recombinase family protein"
     gene            complement(1448..1735)
                     /locus_tag="HI861_RS15065"
                     /old_locus_tag="HI861_015065"
     CDS             complement(1448..1735)
                     /locus_tag="HI861_RS15065"
                     /old_locus_tag="HI861_015065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000312842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_000312842.1"
                     /translation="MAYEILPSKHVIKYLKKLKEKTLKEQFLTIIYDEIAVRPHSGEQK
                     TGDLSGIWAIGFKYAGTTYRVAYEIKDNAVIPNLLCGTHENFYEQLKKIR"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(1725..2054)
                     /locus_tag="HI861_RS15070"
                     /old_locus_tag="HI861_015070"
     CDS             complement(1725..2054)
                     /locus_tag="HI861_RS15070"
                     /old_locus_tag="HI861_015070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005877489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000629052.1"
                     /translation="MITKTRKQGNSIMLTVPKEFDVPNGVEVEAKLVENGILYEFVEPK
                     KEFFDFSEDILADILSEGYSKQEILKEFRNRKNALTSAFKSIAEDTVANSKPMTKEELA
                     AEIGL"
                     /name="hypothetical protein"
     gene            2359..2688
                     /locus_tag="HI861_RS15075"
                     /old_locus_tag="HI861_015075"
     CDS             2359..2688
                     /locus_tag="HI861_RS15075"
                     /old_locus_tag="HI861_015075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000754864.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000754864.1"
                     /translation="MKKVCQVTVVHKEKVNGIKNKLDQKDFSNLLVLGKCFSDFSRIKI
                     FYALETYKEMCVCDLAEILTASVATTSHHLRFLKKHGMAKSRQDGKVVYYSLANEDILS
                     AIRVF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(2975..3460)
                     /gene="vanZ-A"
                     /locus_tag="HI861_RS15080"
                     /old_locus_tag="HI861_015080"
     ARG             complement(2979..3460)
                     /name="vanZ-A"
                     /gene="vanZ-A"
                     /gene_name="glycopeptide resistance protein VanZ-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(3613..4524)
                     /gene="vanY"
                     /locus_tag="HI861_RS15085"
                     /old_locus_tag="HI861_015085"
     CDS             complement(3613..4524)
                     /gene="vanY"
                     /locus_tag="HI861_RS15085"
                     /old_locus_tag="HI861_015085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanY-A/VanY-F/VanY-M family D-Ala-D-Ala
                     carboxypeptidase"
                     /protein_id="WP_000732308.1"
                     /translation="MKKLFFLLLLLFLIYLGYDYVNEALFSQEKVEFQNYDQNPKEHLE
                     NSGTSENTQEKTITEEQVYQGNLLLINSKYPVRQESVKSDIVNLSKHDELINGYGLLDS
                     NIYMSKEIAQKFSEMVNDAVKGGVSHFIINSGYRDFDEQSVLYQEMGAEYALPAGYSEH
                     NSGLSLDVGSSLTKMERAPEGKWIEENAWKYGFILRYPEDKTELTGIQYELWHIRYVGL
                     PHSAIMKEKNFVLEEYMDYLKEEKTISVSVNGEKYEIFYYPVTKNTTIHVPTNLRYEIS
                     GNNIDGVIVTVFPGSTHTNSRR"
                     /name="vanY"
     gene            complement(4952..5560)
                     /locus_tag="HI861_RS15090"
                     /old_locus_tag="HI861_015090"
     CDS             complement(4952..5560)
                     /locus_tag="HI861_RS15090"
                     /old_locus_tag="HI861_015090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-Ala-D-Ala dipeptidase VanX-A"
                     /protein_id="WP_000402348.1"
                     /translation="MEIGFTFLDEIVHGVRWDAKYATWDNFTGKPVDGYEVNRIVGTYE
                     LAESLLKAKELAATQGYGLLLWDGYRPNRAVNCFMQWAAQPENNLTKESYYPNIDRTEM
                     ISKGYVASKSSHSRGSAIDLTLYRLDTGELVPMGSRFDFMDERSHHAANGISCNEAQNR
                     RRLRSIMENSGFEAYSLEWWHYVLRDEPYPNSYFDFPVK"
                     /name="D-Ala-D-Ala dipeptidase VanX-A"
     gene            complement(5566..6597)
                     /gene="vanA"
                     /locus_tag="HI861_RS15095"
                     /old_locus_tag="HI861_015095"
     ARG             complement(5570..6597)
                     /name="vanA"
                     /gene="vanA"
                     /gene_name="D-alanine--(R)-lactate ligase VanA"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="99.71"
                     /coverage="100.0"
     gene            complement(6590..7558)
                     /gene="vanH"
                     /locus_tag="HI861_RS15100"
                     /old_locus_tag="HI861_015100"
     CDS             complement(6590..7558)
                     /gene="vanH"
                     /locus_tag="HI861_RS15100"
                     /old_locus_tag="HI861_015100"
                     /EC_number="1.1.1.28"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001059542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanH-A/VanH-Pt family D-lactate dehydrogenase"
                     /protein_id="WP_105468552.1"
                     /translation="MNNIGITVYGCEQDEADAFHALSPRFGVMATIINANVSESNAKSA
                     PFNQCISVGHKSEISASILLALKRAGVKYISTRSIGCNHIDTTAAKRMGITVDNVAYSP
                     DSVADYTMMLILMAVRNVKSIVRSVEKHDFRLDSDRGKVLSDMTVGVVGTGQIGKAVIE
                     RLRGFGCKVLAYSRSRSIEVNYVPFDELLQNSDIVTLHVPLNTDTHYIISHEQIQRMKQ
                     GAFLINTGRGPLVDTYELVKALENGKLGGAALDVLEGEEEFFYSDCTQKPIDNQFLLKL
                     QRMPNVIITPHTAYYTEQALRDTVEKTIKNCLDFERRQVHE"
                     /name="vanH"
     gene            7890..9182
                     /locus_tag="HI861_RS15105"
                     /old_locus_tag="HI861_015105"
     CDS             7890..9182
                     /locus_tag="HI861_RS15105"
                     /old_locus_tag="HI861_015105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016628567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3-like element IS1251 family transposase"
                     /protein_id="WP_000122610.1"
                     /translation="MSYTHLIKETLDILDLSVTFNENCLTKEKYKGQICHIYRGNLIYT
                     AQECIHCKHQIASDIVRWGTTTVRLLMNDVSEYRTYLELKKQRFKCKACQRTFVADTSV
                     AKKHCFISEKVRWSVVTRLKKNTSMTEIAAQKNLSVSSVYRIMKRFYRPLNPFRTPLPK
                     VLCFDEFKSVRGVSGAMSFIMMDGQTQRLLDIVENRQLPFLKRYFSHFSREIREAVEWI
                     VIDMYAPYVSLVKKLFPKAQLIIDRFHIVQHIGRTFRNHRIKETNQLLKSKEQKHYQLG
                     KQLKRYWKLLQKDERKLDYTRRLWRPGFKAHLTETDIVDRLLKGSPALRVGYQLYQDFL
                     YAVKERDYVSFEELLTNNIMLPEGYQTTLRTFQKFLPQIKNALQQSYSNGPLECLNNHI
                     KVLKRNAYGFRSFYNFKLRIMIRHGNALIFN"
                     /name="ISL3-like element IS1251 family transposase"
     gene            complement(9280..10434)
                     /locus_tag="HI861_RS15110"
                     /old_locus_tag="HI861_015110"
     CDS             complement(9280..10434)
                     /locus_tag="HI861_RS15110"
                     /old_locus_tag="HI861_015110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002305818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="vancomycin resistance histidine kinase VanS-A"
                     /protein_id="WP_002305818.1"
                     /translation="MVIKLKNKKNDYSKLERKLYMYIVAIVVVAIVFVLYIRSMIRGKL
                     GDWILSILENKYDLNHLDAMKLYQYSIRNNIDIFIYVAIVISILILCRVMLSKFAKYFD
                     EINTGIDVLIQNEDKQIELSAEMDVMEQKLNTLKRTLEKREQDAKLAEQRKNDVVMYLA
                     HDIKTPLTSIIGYLSLLDEAPDMPVDQKAKYVHITLDKAYRLEQLIDEFFEITRYNLQT
                     ITLTKTHIDLYYMLVQMTDEFYPQLSAHGKQAVIHAPEDLTVSGDPDKLARVFNNILKN
                     AAAYSEDNSIIDITAGLSGDVVSIEFKNTGSIPKDKLAAIFEKFYRLDNARSSDTGGAG
                     LGLAIAKEIIVQHGGQIYAESNDNYTTFRVELPAMPDLVDKRRS"
                     /name="vancomycin resistance histidine kinase VanS-A"
     gene            complement(10412..11107)
                     /gene="vanR-A"
                     /locus_tag="HI861_RS15115"
                     /old_locus_tag="HI861_015115"
     ARG             complement(10416..11107)
                     /name="vanR-A"
                     /gene="vanR-A"
                     /gene_name="vancomycin resistance response regulator
                     transcription factor VanR-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(11321..11797)
                     /locus_tag="HI861_RS15120"
                     /old_locus_tag="HI861_015120"
     CDS             complement(11321..11797)
                     /locus_tag="HI861_RS15120"
                     /old_locus_tag="HI861_015120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001226077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_029756586.1"
                     /translation="MFFYYSTLFDSRFKTLQQNLQEDDIIYVTDLTRITRSTQDLFELI
                     DNIRDKKASLKSLKDTWLDLSEDNPYSQFLITVMAGVNQLERDLIRMRQREGIELAKKE
                     GKFKGRLKKYHKNHAGMNYAVKLYKEGNMTVNQICEITNVSRASLYRKLSEVNN"
                     /name="recombinase family protein"
     gene            11814..12494
                     /locus_tag="HI861_RS15125"
                     /old_locus_tag="HI861_015125"
     CDS             11814..12494
                     /locus_tag="HI861_RS15125"
                     /old_locus_tag="HI861_015125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(13110..14150)
                     /locus_tag="HI861_RS15130"
                     /old_locus_tag="HI861_015130"
     CDS             complement(13110..14150)
                     /locus_tag="HI861_RS15130"
                     /old_locus_tag="HI861_015130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002343466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_000997689.1"
                     /translation="MNDFNYYKSKEIYREKYYQMPKVFFTNEKYMDLSNDAKIAYMLLK
                     DRFDYSVKNNWVDSDDNIFFIFTVEELMKLLQCREGKVSKIKKELEKAGLLKQKRGRVN
                     KRDGKIESMPNLLYLGKPEVTNQDVFKIMEEEDNTDTTVIAKIANTAKPREINDTTVIA
                     KIANTAKSSHIKDSTVIAKIADNLFYSNSIDTNRHIIDTETDQLQNQVLLDNFVDIMKE
                     DSINTFVPENVLNLIKTFSSTYEDAQKTVQTIHNAKKKAEELEQTVVVYEELESYGIDA
                     DKGLYMTLLKAYQKQKTEKVNNLQNLIFVYVKNWFVEKAIAAKLANEQRETFNELPTVS
                     TENWLE"
                     /name="replication initiator protein A"
     gene            complement(14499..14825)
                     /locus_tag="HI861_RS15135"
                     /old_locus_tag="HI861_015135"
     CDS             complement(14499..14825)
                     /locus_tag="HI861_RS15135"
                     /old_locus_tag="HI861_015135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002299230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000796719.1"
                     /translation="MAEDNRSQAAVSRLLGNKNKKNFKSKEVEEIELTKKNISKVIKDQ
                     GSSVRTADSIRINPILMSALKYWTTIAESDKSKPDVIEDALLKSIPEEYLIEGYKLAKK
                     QNKI"
                     /name="hypothetical protein"
     gene            complement(14812..15600)
                     /locus_tag="HI861_RS15140"
                     /old_locus_tag="HI861_015140"
     CDS             complement(14812..15600)
                     /locus_tag="HI861_RS15140"
                     /old_locus_tag="HI861_015140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002302898.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA]"
                     /GO_process="GO:0007059 - chromosome segregation [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WP_000101106.1"
                     /translation="MARILSVANQKGGVSKTTTSVNLAACLKFVYGKNVLLVDIDPQGN
                     ATDNVGFDIDGTNQPTIYEVLKGEADITDAILDYKGIDVLPADIALSSAEREFTQVGSE
                     HRLKRVLQPIKDNYDYIIIDCPPSLGMLTVNAFTVSDEIIIPVEAAYFSLKGLIKLSET
                     IETVKEYTNDKLEVRGVLFTKYNKRYNISKEMTSAATEISRVIGAKIFKTYIRRTITVD
                     EAQAAGSDLINFNKPSTAEDDYKAFTEEYLKEVGDFDGRR"
                     /name="AAA family ATPase"
     gene            complement(15968..16258)
                     /locus_tag="HI861_RS15145"
                     /old_locus_tag="HI861_015145"
     CDS             complement(15968..16258)
                     /locus_tag="HI861_RS15145"
                     /old_locus_tag="HI861_015145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000026576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000026576.1"
                     /translation="MSINTFVYSHPINVYIIKNLGITVEQFCELYAYPQGTVASWITRQ
                     RRIKSLPASFVYDLSLASSLNMSDVYEKLLSLEKEYDSFKIKHDKKIKKHI"
                     /name="hypothetical protein"
     gene            complement(16394..16573)
                     /locus_tag="HI861_RS15150"
                     /old_locus_tag="HI861_015150"
     CDS             complement(16394..16573)
                     /locus_tag="HI861_RS15150"
                     /old_locus_tag="HI861_015150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001021554.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEAAA
                     GYHNFRFYIFPLYI"
                     /name="hypothetical protein"
     gene            complement(16570..16920)
                     /locus_tag="HI861_RS15155"
                     /old_locus_tag="HI861_015155"
     CDS             complement(16570..16920)
                     /locus_tag="HI861_RS15155"
                     /old_locus_tag="HI861_015155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000568378.1"
                     /translation="MIDYNDRGRLKWAGFYLSDHTEEIDADNEQRTSQNLAKEQMTTEE
                     IAEVLNAAVIKNRSVSIQKEERNAEGYYPEDIIGKILGSDELGIYVGKDKIHYDEIRHI
                     EFYQDNKWSRLE"
                     /name="hypothetical protein"
     gene            complement(16913..18238)
                     /locus_tag="HI861_RS15160"
                     /old_locus_tag="HI861_015160"
     CDS             complement(16913..18238)
                     /locus_tag="HI861_RS15160"
                     /old_locus_tag="HI861_015160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="WP_000969590.1"
                     /translation="MMDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRAD
                     NTGSGLILASSPEAKKRYGITNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTRSLNLFTTEGTRSQRRKKLAQMIQENIKEELGLIATVG
                     VGDNPLLAKLALDNEAKHNEGFVAEWTYENVPEKVWNIPEMTDFWGIGSRMKKRLNQMG
                     IMSIRDLANWNPYTIKNRLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLHIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSDPQKQIDEENLDKIIDK
                     IRQKYGFTSIVHASSMLEGARSITRSTLVGGHAGGNGGIKND"
                     /name="Y-family DNA polymerase"
     gene            18688..19302
                     /locus_tag="HI861_RS15165"
                     /old_locus_tag="HI861_015165"
     CDS             18688..19302
                     /locus_tag="HI861_RS15165"
                     /old_locus_tag="HI861_015165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001261742.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001261742.1"
                     /translation="MRVAYIRVSSIDQNEQRQIEEMKKFGAERIFIEKQSGATITHRPV
                     FQEALDYVRDQDIFIVEAIDRLGRNYDEIIASVNYLKKKNVKLIITSLPIMAEAIGNPL
                     LDKFIKDLIIQILAMIAEQERTESKRRQAQGIKIAKANGVYKGRPKLYSADAKDPQRRL
                     VYKSIVEDLKNGVAIAKIAKDYNVTRQTVYRIKKDSMVNDK"
                     /name="recombinase family protein"
     gene            complement(19467..>19709)
                     /locus_tag="HI861_RS15170"
                     /old_locus_tag="HI861_015170"
                     /pseudo=""
     CDS             complement(19467..>19709)
                     /locus_tag="HI861_RS15170"
                     /old_locus_tag="HI861_015170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455809.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            complement(19913..21232)
                     /locus_tag="HI861_RS15175"
                     /old_locus_tag="HI861_015175"
     CDS             complement(19913..21232)
                     /locus_tag="HI861_RS15175"
                     /old_locus_tag="HI861_015175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002338419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1380-like element IS1678 family transposase"
                     /protein_id="WP_000202380.1"
                     /translation="MTSLHKNQVKFNSNITISHTGGQLSSDSGLVLVKELMNIFGFSEL
                     AKQHIHIEDERAYFTHDNLSILEQFIMQLIAGYSADSAANLLRQDPVFKAVLDRKELAS
                     QSSLSRFLDRLSEENIHELQALNQELIDKARLIRNDTELIIDLDSTHSDTFGHQEQTNY
                     NTHYQTYGYHPLVAFDGLTGDFLKAELRSGNQYTSKGVKEFLTPLLEHYNHSLPNTDIL
                     VRGDSGFATPGVYDSCESKKSHYVIRLKNNRRLGQIAEKSVLYGDNQKWEEREVQYFST
                     TYQAQSWSQSRRVCIRSTREAGELLFRHEFIVTNLSENVSPDTIFSIYAKRGTMENFIK
                     EAKAGFYFDKTDSPRFLENHVRMMLSLIAYNLVNFLRTIGFEEVQKGMTIHSIRLKFLK
                     VAGKLVQTGRRVYLKLSSYHVYQNEFYRVFARLRRASQWI"
                     /name="IS1380-like element IS1678 family transposase"
     gene            complement(21366..21974)
                     /locus_tag="HI861_RS15180"
                     /old_locus_tag="HI861_015180"
     CDS             complement(21366..21974)
                     /locus_tag="HI861_RS15180"
                     /old_locus_tag="HI861_015180"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_224752223.1"
                     /translation="MIERLKDFMISVWDVAMLADESNYTSSIYRLEDSNWIEISLELKT
                     LPNSVNYIIRDITSEAQQLVNYMHGHESIPFSLILLKRSKNISNTRDRFISIITACEIG
                     VKEFYQQEKPDLTLIFENLQSPPVDKLLGSMFKGYFNIEFPKEIRKEIKNFIEKRNKLV
                     HSPQGSKPTIEECFECYMAVLKTFNFFYKINDSLNNSYF"
                     /name="hypothetical protein"
     gene            complement(21998..22153)
                     /locus_tag="HI861_RS15185"
                     /old_locus_tag="HI861_015185"
     CDS             complement(21998..22153)
                     /locus_tag="HI861_RS15185"
                     /old_locus_tag="HI861_015185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002347142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002347142.1"
                     /translation="MEYKFNLNLKEVLPTQGTININGQDNDDDIVIKKIEFIDSDINVF
                     FILKKN"
                     /name="hypothetical protein"
     gene            complement(22612..22869)
                     /locus_tag="HI861_RS15190"
                     /old_locus_tag="HI861_015190"
     CDS             complement(22612..22869)
                     /locus_tag="HI861_RS15190"
                     /old_locus_tag="HI861_015190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016632526.1"
                     /GO_process="GO:0008219 - cell death [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Txe/YoeB family addiction module toxin"
                     /protein_id="WP_000588503.1"
                     /translation="MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGK
                     PEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYSAKDHY"
                     /name="Txe/YoeB family addiction module toxin"
     gene            complement(22862..23131)
                     /locus_tag="HI861_RS15195"
                     /old_locus_tag="HI861_015195"
     CDS             complement(22862..23131)
                     /locus_tag="HI861_RS15195"
                     /old_locus_tag="HI861_015195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016632525.1"
                     /GO_component="GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
                     /protein_id="WP_000388479.1"
                     /translation="MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRD
                     YDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTHDLIEVESDD"
                     /name="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
     gene            complement(23262..23441)
                     /locus_tag="HI861_RS15200"
                     /old_locus_tag="HI861_015200"
     CDS             complement(23262..23441)
                     /locus_tag="HI861_RS15200"
                     /old_locus_tag="HI861_015200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002295613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001120991.1"
                     /translation="MPIAIGNKRLPVTLDEKRQKELQQLKQKYGKSESRIMCIALDLLI
                     AQEKAGFEVPALKK"
                     /name="hypothetical protein"
     gene            23539..23775
                     /locus_tag="HI861_RS15730"
     CDS             23539..23775
                     /locus_tag="HI861_RS15730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002352178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_306297428.1"
                     /translation="MKQNTSIAKNTTKFKCTAAAWRISISPTNRTNNRGMILFIWISFF
                     LLGYRVLPAYFAPPKRRGRLERLVRNKNHSLSY"
                     /name="hypothetical protein"
     gene            complement(23822..>24388)
                     /locus_tag="HI861_RS15205"
                     /old_locus_tag="HI861_015205"
                     /pseudo=""
     CDS             complement(23822..>24388)
                     /locus_tag="HI861_RS15205"
                     /old_locus_tag="HI861_015205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002318326.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            24464..25144
                     /locus_tag="HI861_RS15210"
                     /old_locus_tag="HI861_015210"
     CDS             24464..25144
                     /locus_tag="HI861_RS15210"
                     /old_locus_tag="HI861_015210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            25879..25965
                     /locus_tag="HI861_RS15215"
                     /old_locus_tag="HI861_015215"
     CDS             25879..25965
                     /locus_tag="HI861_RS15215"
                     /old_locus_tag="HI861_015215"
                     /inference="COORDINATES: protein motif:HMM:NF033608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_125669474.1"
                     /translation="MFTNFICSLLVGLLSALFSYWLNNRNKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(26267..26491)
                     /locus_tag="HI861_RS15220"
                     /old_locus_tag="HI861_015220"
     CDS             complement(26267..26491)
                     /locus_tag="HI861_RS15220"
                     /old_locus_tag="HI861_015220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000410576.1"
                     /translation="MEKFPYEYFQNLEKLEQAIQAIKFDLTDEKLLEYKNMTPERKRSL
                     EKLMQLVNEDGGISDAAFDAWSEFHGEYN"
                     /name="hypothetical protein"
     gene            26857..27138
                     /locus_tag="HI861_RS15225"
                     /old_locus_tag="HI861_015225"
     CDS             26857..27138
                     /locus_tag="HI861_RS15225"
                     /old_locus_tag="HI861_015225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000353845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_086325443.1"
                     /translation="MDILVRNIDPKFVATIDKRCQELTNKTGEKWSRNKYLKVLIESDF
                     DRQLTTYKKDQFDLLLDKFIAIQTENTQILSEYVYTNNQIIEMLIGGI"
                     /name="hypothetical protein"
     gene            27140..27556
                     /locus_tag="HI861_RS15230"
                     /old_locus_tag="HI861_015230"
     CDS             27140..27556
                     /locus_tag="HI861_RS15230"
                     /old_locus_tag="HI861_015230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001232859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001232859.1"
                     /translation="MRKTSVQKHVTLYPSHVDVLDSIIEKNPDINNYSEAIRFLCMSYE
                     PDTNTTTTSNQAKLNAMGKEISIMTEIIAEFADLYLKDTGVLIGTNSKVYQEVKEKIEA
                     KLNPSNRNRPKNHQKETSQTVTSRNFDPTNFLKR"
                     /name="hypothetical protein"
     gene            complement(27693..28301)
                     /locus_tag="HI861_RS15055"
                     /old_locus_tag="HI861_015055"
     CDS             complement(27693..28301)
                     /locus_tag="HI861_RS15055"
                     /old_locus_tag="HI861_015055"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_000654861.1"
                     /translation="MKDRGLKKVRFSFEELKELSDYKMTATKAFVGDLEKLYKDMLNLT
                     YRTEDEDSIRYFVLFTGFEINKTKKFVEVSVNPDLEYIINGLTAEFSRFELSAFTSLRS
                     TYAKTLFRLLMQYRSTGYYVVRIEEFRSLMDIPEYYQMGNIDQKVLNPALRELKKYFND
                     LKVTKIKAKKGNKIAKLEFTFSSLTSDLPKISLRNWLEE"
                     /name="replication initiation protein"
     ARG             complement(6594..7558)
                     /name="vanH-A"
                     /gene="vanH-A"
                     /gene_name="D-lactate dehydrogenase VanH-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="99.69"
                     /coverage="100.0"
     ARG             complement(9284..10434)
                     /name="vanS-A"
                     /gene="vanS-A"
                     /gene_name="vancomycin resistance histidine kinase VanS-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(3617..4524)
                     /name="vanY-A"
                     /gene="vanY-A"
                     /gene_name="D-Ala-D-Ala carboxypeptidase VanY-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="99.67"
                     /coverage="100.0"
     ARG             complement(4956..5560)
                     /name="vanX-A"
                     /gene="vanX-A"
                     /gene_name="D-Ala-D-Ala dipeptidase VanX-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(6591..7558)
                     /name="vanH gene in vanA cluster"
                     /gene="vanH gene in vanA cluster"
                     /gene_name="vanH; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.69"
                     /coverage="100.0"
     ARG             complement(10413..11107)
                     /name="vanR gene in vanA cluster"
                     /gene="vanR gene in vanA cluster"
                     /gene_name="glycopeptide resistance gene cluster; vanR"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(3614..4524)
                     /name="vanY gene in vanA cluster"
                     /gene="vanY gene in vanA cluster"
                     /gene_name="vanY; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.67"
                     /coverage="100.0"
     ARG             complement(2976..3460)
                     /name="vanZ gene in vanA cluster"
                     /gene="vanZ gene in vanA cluster"
                     /gene_name="vanZ; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(9281..10422)
                     /name="vanS gene in vanA cluster"
                     /gene="vanS gene in vanA cluster"
                     /gene_name="vanS; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.74"
                     /coverage="98.96"
     ARG             complement(4953..5560)
                     /name="vanX gene in vanA cluster"
                     /gene="vanX gene in vanA cluster"
                     /gene_name="vanX; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.5"
                     /coverage="100.0"
     Typing          complement(13111..14150)
                     /name="rep_cluster_889"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(27694..28401)
                     /name="rep_cluster_1763"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="98.0"
                     /evalue="0.0"
ORIGIN
        1 caatttgagt gtaacataaa tggctttttt atttgtctcg cttaattata caaacggcga
       61 agttaaaact tttttagcag attttaaagt ttcgtcaaaa ctaatatatt ctggtagctg
      121 agcattcaaa tagctttcag acttcagaag aaaattacga gcatttttat agtccatctc
      181 taataaagtt attctttttt tatccaatac attcagctca attccttata atattctatt
      241 ccttagtatc tcaacattat ttactttata aaacgaataa attttgtagt tctaattcaa
      301 atattgcatg ttatatctaa tatgggagca ttttataatt ttcattgtga taaactcgtt
      361 attaacttta ggatacacta gttaggatta aattaggtat ctagaaattt acttaagatt
      421 tttttgttta tttcgtatac acactcgtat caaaaacaat cgattatgag acaaaatgaa
      481 atgacctctt ttattaaata aaagaggtca tattttgtat cataacttgt tgcattaact
      541 atgtatctat aactcccttt tatgatacaa tcaagccaga attaaagtac gaaaggaaga
      601 aaagcatgag tggatacatt tatggttatg cccgagtgag tacacgttca caagaactaa
      661 atcgtcaatt agacttactc aatgaacaaa attgtaatga aatcctaact gagaaaatga
      721 cgggaaccaa agcggttcgt ccccaactaa atcgtttaaa agataaaatt cgtccgggag
      781 atacggtaat tgtagaaagt ttttctcgat tgggtcgtag tacaaaggat ttgattgacc
      841 ttgttaccta ttttgaagaa caccatgtta agctggtgag cttgaaagaa aacttcgata
      901 ccagcacgcc tcacggacgc ttaatgatga ctgtcttcca agcatttagt cagttcgaac
      961 gtgatttaat tgttgaacgt accaaagaag gtttgaaaag tgcacgtgcg agaggtcgta
     1021 aaggtggccg tccacgagtg aaccagaaag atgttgatcg agcagtaaaa ttgtataaaa
     1081 gtcaggttta tagcgtaaaa gaaattacgg aaatgactgg tattagcaag gcaacactct
     1141 accgctactt aaaagacaat agggaataat ctattttaat ctttaggaat ctataatatt
     1201 tatgggagaa ttagagtgat ttttttatta ttactaaaaa acaatataaa ataacgcatt
     1261 ttaagccctc tttgtgcata aggatgaagc ttttaatttg aaagaggctt aaaatgcgtt
     1321 ttaatttttt ctatttttca taaatatata ggttagtggt ttaaaattat agggtattac
     1381 aactctcagc tgttaaaaat tatcttttaa agtgtcgtct atcctctcaa gttgaaacat
     1441 tgggttctta cctaatcttt tttaattgtt cataaaaatt ttcatgcgtt ccacatagta
     1501 agttaggtat cactgcatta tctttaattt catatgcaac gcgatatgtc gtacctgcat
     1561 acttgaatcc aatagcccaa attcctgata aatcacccgt tttttgttct cccgaatgag
     1621 gacgaactgc tatctcatca taaattatcg ttaaaaattg ttcttttaat gttttctctt
     1681 ttaatttttt tagatacttt attacgtgtt tagaaggtag aatctcataa gccaatttct
     1741 gctgccaact cctcttttgt catcggttta gaatttgcaa cagtatcttc agcaatagat
     1801 ttaaatgcag aagttaacgc attttttcta tttctaaatt cttttaagat ctcttgtttg
     1861 ctataacctt ctgaaagaat atcagccaaa atatcttcac taaaatcaaa aaattctttt
     1921 ttaggctcta caaactcata aaggatacca ttctctacaa gcttagcttc tacttcaaca
     1981 ccattgggca catcgaattc tttagggacc gttaacataa tagaatttcc ttgttttctt
     2041 gtttttgtaa tcatattatt tcctccatta ttttacattt cgtaattact tagtaattac
     2101 attgtacgct atttttagta gaaatacaaa ataataaaac tcctttagaa caattttcaa
     2161 aggagtttta tttgattagg aaattatgta gaataataat atgtttttaa cttggaatca
     2221 aaaacgcact tgcaagtaag tttacttcaa tacatgaaat tgcttataat agtgtattgg
     2281 aattaaggta gattgacaaa agagtgatca aataggtata cttcattcaa ataatcgttt
     2341 gaatgtgagg tgagatgaat gaaaaaagtt tgccaagtga ctgtcgtaca taaagaaaaa
     2401 gtaaatggaa taaaaaataa attggatcaa aaagattttt caaacttact tgtgttaggg
     2461 aaatgtttca gcgatttttc tagaattaaa attttctatg ctttagaaac ctataaggaa
     2521 atgtgcgtct gtgatttagc agaaatactt actgctagtg tcgctacaac gtcacaccat
     2581 ttacgttttt taaaaaaaca tggaatggca aaatcacgtc aagatggaaa agtagtttat
     2641 tactctttag cgaatgaaga catcctttcc gctattcgtg ttttttaaag ttatcagaaa
     2701 atctatctat gaaatcttag tttgggggta ccgtcaggaa aatgcggatt tacaacgtta
     2761 aggaaattta ttaaagagac caattcctca gcactaaaat tgataattgg gctttctttg
     2821 ttactatagt gttaggtaag ctttttactt tatcaccggt tttcccctca cttcacacct
     2881 acgggcgagt ttccccacat cccgttttcc atctaatcca attcattcaa tatctttatg
     2941 tgtatgaaag atcagattgc ttgatttaga catcttacac gtaatttatt cttaaatggg
     3001 tacggtaaac gagcaataat acgagcaaaa gtatacctac aaaaataata actctgtcta
     3061 attttttttg attcatatgc ttattgctta aaccatataa tttcagtcca agaaagcctc
     3121 caacagtatt tgtaattaca tctgttatgt ctgtcgctcc aatagcgaag ataaattgaa
     3181 ttatttcaaa agtaagactt aaaaccagta caaaagcaaa cttaggtaaa aatccgattt
     3241 ctttaaaatt gacattcaaa agcaagccaa atggaataaa gattataaca ttatctatca
     3301 tctctctgaa attcccagta gcagtaaatg gagtcaagtt aagacttctt tgatgataat
     3361 taaatactga taaaatattg tattgtaatt tgaataacac taaccagatt agtgtcacta
     3421 aatataaagc tagcaatcct ctagataata tttttcccaa tataatttcc tctaattctt
     3481 ttgtttaagt tgtatcatta gtatagcaat gtcctagtta acgtgggttt taaattaaaa
     3541 agctaacgtt accccaaaag tgctagtaca ataatgctgt tcattaattt cgttggtttc
     3601 attccgccat ccttacctcc ttgaattagt atgtgttgat ccgggaaaca ctgtcacaat
     3661 tacaccgtct atattgtttc ctgatatctc ataacgaaga ttagtcggca catgaatggt
     3721 ggtattttta gtaacaggat aataaaagat ctcatatttt tccccattta cactaacaga
     3781 aatggttttt tcttctttta ggtaatccat atattcctcg agaacgaaat tcttttcttt
     3841 cataatcgca ctatgtggta aaccaacata gcgaatatgc catagttcat attgaattcc
     3901 tgttaactct gttttgtcct ctggataacg taaaatgaac ccgtatttcc aagcattttc
     3961 ttctatccac tttccttcag gggctcgttc cattttcgtc aagcttgatc ctacatctag
     4021 tgataaacct gaattatgct cactataacc tgctggtaag gcatactcag cccccatttc
     4081 ttggtaaagc acactttgct catcaaagtc tcgatagcca ctattaataa taaaatgact
     4141 aacgccaccc tttacagcat cattgaccat ctctgaaaat ttttgtgcta tttcttttga
     4201 catataaata ttactatcaa gcaacccgta tccatttatt aattcgtcat gtttagataa
     4261 attcacgata tctgacttca cactttcttg gcgaacagga tatttactat tgattaatag
     4321 cagatttcct tgataaacct gttcttctgt aattgttttc tcttgggtat tttcagaagt
     4381 cccactattt tctaaatgtt ctttgggatt ttgatcataa ttttgaaatt cgactttttc
     4441 ctgagaaaac agtgcttcat taacgtagtc ataacctaag tatattaaga ataacaataa
     4501 caataaaaaa aacaacttct tcattttcag tctcctcctt aactatatag ttggaagtat
     4561 gaaatatttc tagaatcttc cccttaaacg gcacaatctc gtttgagatt gtgccgtttt
     4621 gccccgtaaa ttacagtcaa ttatttcgcc ctactggatt tactattatc accaatgtag
     4681 atgaattttc ataagtgata cccatgctga atttaacgag gctgaactgc ctgttgacaa
     4741 tgggcggtgt gaaataccac ccctctatgc gatcagtctt attatcaggc tatcttgccg
     4801 cagcgcacgc agataatgac cgcaatatcg ctctgcctta catcttcaat actatctact
     4861 atatataaat tccctaagaa ccagttacat acgtcgggtt tcctgccgaa agagttagct
     4921 tatatagttt gtccgtgcaa cggttaaaag tttatttaac ggggaaatca aaatagctat
     4981 tggggtatgg ttcgtctctt aatacatagt gccaccattc gaggctatat gcttcaaacc
     5041 cactgttttc catgatggag cgcaaacgtc tgcgattttg cgcttcattg catgatattc
     5101 catttgccgc atgatgagag cgttcatcca taaaatcaaa tcggctcccc attggtacaa
     5161 gctcacccgt gtctaatcga taaagcgtaa gatcaatggc actgccgcgg ctatggcttg
     5221 attttgaagc cacgtatcct tttgaaatca tctcagttcg gtcaatattg ggataataac
     5281 tttcctttgt caggttattt tccggctgtg cagcccattg cataaaacag tttacagcac
     5341 gattaggacg gtaaccgtcc catagaagca atccgtaccc ttgggtagca gccagttctt
     5401 ttgccttcaa aagcgattca gccaactcgt atgtccctac aatgcgattt acttcataac
     5461 cgtcaaccgg ttttccggtg aaattatccc aagtggcata tttagcgtcc caacgaacac
     5521 cgtgtactat ttcatctaaa aaagtaaatc ctatttccat gcttatcacc cctttaacgc
     5581 taatacgatc aagcggtcaa tcagttcggg aagtgcaata cctgcagcgg ccatcatacg
     5641 gggataacga ctgtatgacg tgaaaccggg cagagtattg acttcgttca gtacaatgcg
     5701 gccgttatct tgtaaaaaca tatccacacg ggctagacct ctacagccga gcgctttata
     5761 tatttttttt gccgtttcct gtatccgtcc tcgctcctct gctgaaaggt ctgcgggaac
     5821 ggttataact gcgttttcag agcctttttc cggctcgact tcctgatgaa tacgaaagat
     5881 tccgtactgc agcctgattt ggtccacctc gccaacagct aacgcggcac tgtttcccaa
     5941 taccgcacaa ccgacctcac agcccgaaac agcctgctca attaagattt tgctgtcata
     6001 ttgtcttgcc gattcaattg cgtagtccaa ttcgtccgcg ctattgactt ttttcacacc
     6061 gaaggatgag cctgaacgcg ccggcttaac aaaaacagga taggtaaacg tagctgccac
     6121 cggcctatca tctttattaa taacccaaaa ggcgggagta gctatcccag catttttcgc
     6181 aacgatgtat gtcaacgatt tgtccataca aattgctgag ctttgaatat cgcagcctac
     6241 aaaagggata ccggacaatt caaacagacc ttgtatggat ccatcttcac ctgacttgcc
     6301 atgcaaagct gaaaatgcta catcaacatg gttgatttca tattcatggt tctttttaac
     6361 aagtaatccg tgcatttttt tatccggcga gagtacagct gaatagcaat tgtcgttttc
     6421 ccattccgcg caaggttttt cgcacatttt ccatacacca gatttcgtaa ttccaatgta
     6481 taacggctcg tatttttctt tattaatgtt agcggctatc tctattgcag attttaccga
     6541 tacgtcatgc tcctctgagc aacccccaaa cagtattgca acttttattc tattcatgca
     6601 cctgtctcct ttcaaaatcc aaacagtttt taatggtttt ttcaacggta tcacgcaacg
     6661 cttgctcggt ataataggcc gtatgcggtg tgattatcac gttaggcatt ctttgaagtt
     6721 taagtaaaaa ttgattatca attggttttt gggtgcaatc agagtagaaa aactcttcct
     6781 ctccttccaa tacatccaat gcggcaccgc ccagtttccc gttttctaat gctttaacca
     6841 actcataggt atctacaagt ggaccgcgcc cagtattgat aagaaatgct ccttgcttca
     6901 ttctctgtat ttgttcgtgg ctgataatat agtgcgtatc cgtattgagc ggcacatgaa
     6961 gcgtaacgat atcgctattt tgcagcaact catcaaacgg tacatagttt acctctatac
     7021 ttcggctgcg actataagcc aacactttac atccaaatcc tcgcagccgc tcaataaccg
     7081 ctttgcctat ctggcccgtt cccaccacac caactgtcat gtcgctgagt accttgccac
     7141 ggtcgctgtc caacctgaaa tcatgttttt ccacagagcg cacaatcgat tttacgttgc
     7201 gtactgccat aagaattagc atcatagtat aatcggcaac gctatccggc gagtacgcca
     7261 cattgtcgac agtgatgccc attctcttag cagcagttgt atctatatga ttgcagccga
     7321 tgcttcgggt agaaatatat ttcacaccgg ctctcttcag cgcaagaaga atagaggcgg
     7381 aaatctctga tttatgtccc acactgatac attgattgaa aggcgcggat ttggcgttgg
     7441 attccgacac gttggcgtta attatcgttg ccataacgcc aaagcgaggc gaaagagcat
     7501 ggaatgcatc tgcctcatcc tgctcacatc cataaacagt aatgccgatg ttattcataa
     7561 ttaagaccaa ccctttctgt gaaaggcacc aaataaaacg gggatgccaa tggtaatctt
     7621 gtcaaatctt tctctgaaga acgaaaacgg ctcgttctta cggtattaag tctaccgtgt
     7681 aagaacgagc cgtttcttaa tattaaattg ttaatttcct aagaaaaagt aaagataacc
     7741 ttgagatttt cctaaaaaat tatggctcta tactttttga tgttggtgga tgacaccagc
     7801 atctttttta ttttccaaaa catatagaaa agacaccttg aaatccttta gaattaattt
     7861 ggcgaaccaa cccaaaagga ggaatcaaga tgtcttacac tcaccttatc aaagaaacat
     7921 tagatattct agacttatca gttactttta acgaaaattg tctcacaaaa gaaaaataca
     7981 aagggcaaat ctgtcatatt tatcgtggaa acttgattta tacagcccaa gaatgcatcc
     8041 actgtaaaca ccagattgct tcagatattg tgcgttgggg tacaacaacc gtccggttgt
     8101 taatgaacga tgtttctgaa taccgtacct acctcgaatt gaaaaagcaa cgcttcaaat
     8161 gcaaagcttg tcagcggacc tttgtcgcag atacttctgt tgcgaaaaaa cattgtttca
     8221 tcagtgagaa agtccgctgg tctgtcgtga ctcgtctgaa aaaaaatacc tcaatgacag
     8281 agatcgccgc tcagaaaaat ctatcggtct cttctgttta ccgtattatg aagcgatttt
     8341 atcgtccgtt gaatcctttt cggacaccgt tacctaaggt actttgtttt gatgaattca
     8401 aatcagttcg gggtgtttca ggtgctatga gtttcatcat gatggatgga caaacacagc
     8461 gcttattgga cattgtcgag aaccgacaac tgcctttttt aaaacgttat tttagtcatt
     8521 tttcacgaga aattcgtgaa gcggtcgaat ggatcgtgat tgatatgtac gctccttatg
     8581 tatcgctcgt taaaaagctg tttccaaaag cacagctgat tattgaccgg tttcacatcg
     8641 tccaacatat tggtcgtacc tttcgcaatc atcgaatcaa agaaacgaac caactattaa
     8701 aaagcaaaga acaaaaacac tatcaattag gtaagcaatt aaaaagatac tggaaacttc
     8761 ttcaaaaaga tgaacgcaag cttgattata ctcgacgcct ttggcgacct ggcttcaaag
     8821 ctcatttaac agagaccgat attgtggatc gcttactgaa agggagccct gctttgcgtg
     8881 taggctatca gttatatcaa gactttcttt acgctgtaaa ggaacgagac tacgtatcgt
     8941 ttgaagaact acttaccaat aatatcatgc ttcccgaagg ctatcagacg accttgagaa
     9001 cgttccagaa atttctgcca caaatcaaaa atgctttaca acaaagttat tcaaatggcc
     9061 cacttgaatg tctgaacaac catatcaaag tgttaaaacg aaatgcatat ggctttcgta
     9121 gcttttataa tttcaaattg cgcatcatga ttcgtcatgg caacgcattg attttcaact
     9181 aaaaaagatc aagaggaact gatccacttg atctccaatt attctaagat ttctctttac
     9241 caacatcatt tgacaaagag ccaaaattat atacatctct taggacctcc ttttatcaac
     9301 caagtctggc atcgctggaa gctctaccct aaacgtcgta tagttatcat tgctttccgc
     9361 gtaaatctgc cctccatgct gaacaataat ttcttttgca atcgccaatc caagtcccgc
     9421 gccacccgta tcggaagaac gagcattgtc cagcctatag aacttttcaa atatggcagc
     9481 tagcttatct tttgggatgc ttccagtgtt cttgaattcg attgacacca catccccgga
     9541 gaggcccgcg gtaatgtcaa tgatgctgtt atcctcactg tatgcagcgg cgtttttcaa
     9601 aatgttgtta aagactctcg cgagtttatc agggtcgccg gacacggtca gatcctcggg
     9661 ggcgtgaata accgcctgtt ttccatgtgc ggaaagctga ggataaaatt catcggtcat
     9721 ctgcaccagc atatagtata ggtctatgtg cgtttttgtt agcgttatcg tttgtaggtt
     9781 ataccgtgta atctcaaaaa actcgtcgat tagctgttcg agtcgatacg ctttgtccaa
     9841 cgtgatatgc acatactttg ccttttgatc taccggcatg tctggagcct cgtcaagcag
     9901 gctcaaataa ccgataatgg atgtaagggg cgttttaata tcgtgcgcca agtacataac
     9961 aacgtcattt tttctttgtt cggccagctt tgcatcctgc tctcgctttt ccagagtccg
    10021 ttttaatgtg ttgagctttt gttccataac atccatttcc gcagaaagct caatttgttt
    10081 atcttcgttc tgaataagta catcaatgcc ggtatttatc tcgtcaaagt attttgcgaa
    10141 ttttgaaagc atgacgcgac atagaataag aatactaatg acaatcgcca cataaataaa
    10201 gatatctata ttgttccgta tggaatattg atataatttc atcgcgtcca ggtgatttaa
    10261 gtcatatttg ttttccaaaa tacttaagat ccaatcccca agtttccctc ggatcattga
    10321 acgaatatac aacacgaata caattgctac cacaacaatt gcaacgatat acatgtaaag
    10381 ttttcgttct agtttggaat agtcgttttt tttatttttc aattttataa ccaacccccc
    10441 ataccgtttt tatatatttc ggattatcaa tggtgtcgtt cattttttcg cgcaaatgcc
    10501 ggatatgcac ggtgatggtg ttgttgctct tgctgaaata ttcgtcgccc catatctcat
    10561 gaaatagcag ctcggagcta accacattcc ccttgttttc acagaggatt cgcagtattg
    10621 aaaactcggt gggagtaagg gataactgct tctcgttcag ataacactca tgggtgttaa
    10681 cattaatgac aaggccggag tggacgataa cattttcgtt ctgctccttt actccactga
    10741 attttttgta tcggcgcaac tgggccttta cccgagcaat taactccagt gggcgaaagg
    10801 gcttcgttat ataatcatcc gcgccgattg ttaaccctgt aattttatct acctctgtat
    10861 ctttcccggt cagcatgata atcggatagg tgtgcttgtc ccttattttt tgacagatag
    10921 taaggccgct tgtgccggga agcatgatgt ccaatatggc aaggtcaatc tcagacttgt
    10981 ctatacattc caatgcttct ttggcggtat agtatttgaa aaccgtataa ttctcgtttt
    11041 ttaagtataa ttcaaccaaa tcggcaattt catgttcatc atccacaata agtattttat
    11101 cgctcatagt tatcaccctt tcacataagt ttgcccttaa taatttatca gattataggg
    11161 ccgaatttat aagcatttac ataataaatg actaagaatt tcttaagatg atgattcttt
    11221 ttttatcaaa gggcttttcg gcatcgctag gaggctgtta atattttata gtttcctttt
    11281 cttctttaaa aatattgccc attagcggaa tacagaatgg ctaattattc acttctgata
    11341 atttcctgta taatgaagcc ctagatacat tagtaatttc acaaatttga tttacagtca
    11401 tatttccttc tttatatagc tttaccgcat aattcattcc tgcgtgattt ttatgatact
    11461 tctttaatcg acctttaaac tttccttctt tcttagccaa ttcaatccct tcacgttgtc
    11521 tcatccgaat aagatctcgc tctaattggt taacaccagc cattacagta attaagaatt
    11581 ggctgtatgg attatcttct gataaatcaa gccatgtatc ttttagtgat tttaaacttg
    11641 cctttttatc tcgtatgtta tcgattaatt caaatagatc ttgtgtacta cgagtgattc
    11701 gagttaagtc tgtaacataa atgatgtcat cttcctgtag gttctgttgc aaagttttaa
    11761 atctactatc aaataaggta gaataataga aaaagatagc aggaggaatg acgatgaatc
    11821 attttaaagg aaagcaattt cagcaggatg tgattattgt agccgtgggc tactatcttc
    11881 gttataacct tagctatcgt gaagttcaag aaatcttata tgatcgtggc attaacgttt
    11941 ctcatacgac gatttatcgt tgggtgcaag aatatggcaa actactctat caaatttgga
    12001 aaaagaaaaa taaaaaatcc ttttattcat ggaaaatgga tgaaacgtac atcaaaatta
    12061 aaggaaaatg gcattatttg tatcgagcca tcgatgcaga tggtttaacc ttggatattt
    12121 ggttacgtaa aaaacgggac acacaagcag cctatgcttt tcttaagcgg ttagtgaagc
    12181 agtttgatga accgaaggtt gtagtcacag ataaagcccc ctctattaca agtgccttta
    12241 agaaactaaa agaatacggc ttttatcaag ggacagaaca tcgtaccatt aaatacctga
    12301 ataatttgat tgaacaagac catcgtccag taaagagacg caataaattc tatcgaagtt
    12361 tacgcactgc ctctaccacg attaaaggca tggaagccat tcgaggatta tataagaaaa
    12421 cccgaaaaga aggcactctc ttcgggtttt cggtctgtac tgaaatcaag gtattattgg
    12481 gaatcccagc ttaaatcata gataccgtaa gggattttat tctttattta aaactttgca
    12541 acagaaccgt ccgttgcggg taataccgta acactgaagg gcacgcatta aggcgtcatc
    12601 ttaatgcttt cctgtaggac actgacggag attaccagtc tcccgagcct tacaggggcc
    12661 tttctttttt ttgtattttc aattatcaca atttatcgtc caaaagtgca gaacgaaaat
    12721 caattcatca caagcatatc agacaattaa atttaaaaca actaaaaata tacaaaaaag
    12781 tgtaattgaa tattagcagc actgcctgaa aagaagtaat atcaggcttt tcagcttggg
    12841 gaaataagtg aattacctct cttcatgaat tattataact caaaaaagca catatgcaaa
    12901 cactagttcc ctattttttt gaatgaaaaa taactaaaat atctaacgat tatgacttta
    12961 aaacctacgt ttgtgattgt tttcataaac ttttaatcta aaaactccgg aataatagct
    13021 atttatttgt aacatttgta ataaaattaa aatcataaaa aagttctaat ttaaaattga
    13081 tcatttttat agtgatcgct ttttatcaac tactctagcc aattttccgt actaactgtt
    13141 ggtaattcgt taaatgtttc tctttgttcg tttgcaagct ttgccgcaat agctttttcg
    13201 acaaaccaat tttttacata aacgaaaatt agattctgca aattgtttac tttttcagtt
    13261 ttttgttttt gataagcttt cagcaaagtc atatataatc ctttgtcagc atcaattcca
    13321 taagattcca gttcttcata aacaacaact gtttgctcta attcttcagc ttttttcttt
    13381 gcattatgaa tagtttggac ggttttttga gcgtcttcgt aagtactaga aaatgttttt
    13441 atcaagttta atacattttc tggtacaaat gtatttatac tgtcctcttt catgatgtcg
    13501 acgaagttat ctagtaaaac ttgattttgt aactgatcag tttcagtgtc tattatgtgt
    13561 ctattagtgt ctatagaatt agaatagaat agattgtctg cgattttcgc aattacggtt
    13621 gagtccttga tatgactgga ttttgccgta tttgcgattt tcgcaattac ggtggtatca
    13681 ttgatttctc gcggttttgc cgtatttgcg attttcgcaa ttacggtggt atcagtattg
    13741 tcttcctctt ccatgatttt aaagacgtct tgattcgtta cttctggctt gcctaagtac
    13801 aataaattag gcatggattc aatcttaccg tcacgtttat ttactcttcc tctcttctgt
    13861 ttcagaagac ctgctttttc taattccttt ttgattttag atactttacc ttcgcggcat
    13921 tgtaacaatt tcattaattc ttcaactgtg aatatgaaaa atatattatc atcagaatct
    13981 acccagttat ttttgactga ataatcaaat cgatctttaa gtagcatata agcaattttt
    14041 gcatcatttg atagatccat gtatttttcg ttagtaaaaa ataccttagg catttgataa
    14101 tatttttcac gataaatttc ttttgatttg taataattaa aatcattcat agccaatcct
    14161 ctttctgtag gatagcgttt tgttcaaaac tatgttacaa tgaattaaac aaatatatct
    14221 atccactata tatttttcta ctgctgataa gtcgccaaac tttgttaaag cagtagtctt
    14281 tttttatctt tttttagttt accttaaaaa ataaattaaa gcaaaccgct ctatttcaag
    14341 gtttaagctc atagtaacta tatcacgata ttacaataat attatatcac gatatcgtaa
    14401 tattacaata tgaagataag cgacttatca gctttgatac tactgatttt tataaaaaaa
    14461 atatcacgat attatgatat cgtgatattg aatgtaaatt aaattttatt ttgtttcttt
    14521 gctagtttat atccttcaat caagtattct tcaggtatgg actttaatag cgcatcttct
    14581 ataacgtctg gtttactttt gtctgattca gcaatagtcg tccaatattt gagtgctgac
    14641 attagaattg gatttatacg aatgctatct gctgttctta cactacttcc ttgatctttt
    14701 atgactttac ttatattttt cttggttaat tcgatttctt ctacttcttt tgatttaaaa
    14761 ttctttttat ttttatttcc tagtaatcta cttactgcag cttgactgcg attatcttct
    14821 gccatcaaaa tcaccaactt cttttaaata ttcttctgta aatgctttat agtcatcttc
    14881 agctgttgag ggtttattaa aattgattag atctgatcca gcagcttgcg cttcgtcaac
    14941 ggttattgtc ctacgaatat aagttttgaa aatttttgca ccaatgactc tagaaatttc
    15001 ggttgctgca gacgtcattt ctttagaaat gttataacgc ttattatact tagtaaatag
    15061 aactcctcgt acttcaagct tgtcgttcgt atattctttt accgtttcaa tagtttcact
    15121 taactttatt agtcctttta atgagaaata cgcagcttca actggaatga taatttcatc
    15181 agaaacagta aatgcgttga ctgtaagcat tcctaaactt ggtggacaat caattataat
    15241 ataatcatag ttgtccttga ttggttgaag tactctttta agcctgtgtt cacttcctac
    15301 ttgagtaaat tccctctctg cagaagaaag ggctatgtcg gctggcaaaa catcaattcc
    15361 tttatagtcc agaatagcat ctgtaatgtc agcctcccct tttaatactt cataaattgt
    15421 aggttggttt gttccatcta tatcgaaacc tacattatct gtagcatttc cctgaggatc
    15481 aatgtccact aaaagtacat ttttaccgta aacaaatttc aaacatgctg ctaaattaac
    15541 gctagtcgta gttttagaaa ctccaccttt ttgattggct actgacaata ttcttgccat
    15601 taaaatatcc cccattcatc ttatattata atataattat atcataatat tgtgatattg
    15661 caatatcgta tatgcattat attgtaatat tgtgtgatta ttttgtttta aagatatata
    15721 tcggttcgga tataaagatt attcatatgt tattcgaaat taaaataatc actttttatt
    15781 actttaaaat tttttattaa tgataagaaa tatgttttgc gagcagcaac tagaataatt
    15841 taaacattac taaactgtct atattgttac taataattcc cttcttatag tgcattttct
    15901 tagaaaaaaa caatattacg atatcatgat attaagatat cgtaatatta tacaattgtg
    15961 attgatatta tatatgtttt tttatttttt tatcatgttt aatcttgaag gaatcatatt
    16021 ctttttctaa agacaggagc ttttcataaa catcagacat gtttaaacta gaggccaggc
    16081 ttaaatcata aacgaatgaa gcaggtaatg attttattct acgttgtcgg gttatccagc
    16141 ttgcaaccgt tccttgtggg taggcatata actcacaaaa ttgttctaca gtgattccta
    16201 aattcttgat aatgtaaaca ttgatcgggt gcgagtaaac aaatgtattg atagacatgg
    16261 tgcgtaagcc tactttcttt tattattgcg tttgcaataa tagtttaaca cacgcattat
    16321 tctagtatct actcctattt gtaaaaacaa aaaaggattc atagagataa ctctatagaa
    16381 tccgtaaaat accttatata tataacggga agatataaaa cctaaaatta tgataacctg
    16441 ctgcagcttc tacatagaaa gagaagcgct caacaccaac ctcatttatc aaacgttggc
    16501 cataacccca aatctcttct gatagctgat caaaggttat atactttagc tcatattgct
    16561 ggataatgtt cattctaatc gactccattt attatcctgg taaaattcga tatgacgtat
    16621 ttcgtcgtag tgaattttgt cttttccaac gtagatcccc agctcatcac tacctaagat
    16681 cttgccaatg atatcttctg gatagtatcc ttcagcgttt cgttcttctt tttgaataga
    16741 tactgatcta ttttttatga ctgcagcgtt caatacttcc gcaatctctt cagtcgtcat
    16801 ttgttctttt gctaaatttt gactggttcg ttgttcattg tcggcatcaa tttcttcagt
    16861 atgatcagat aaataaaacc ctgcccactt taaacgtcca cgatcattgt aatcaatcat
    16921 ttttaattcc cccatttccg cccgcatgac caccaacaag tgtgcttcta gtaatgcttc
    16981 tagcgccttc taacattgaa gaagcatgta caatcgacgt aaaaccatat ttttgccgaa
    17041 tcttgtcaat aattttatct aaattttctt cgtcaatttg cttttgtgga tcactaaata
    17101 aatccagctg aagcgaatcg gtgtacacaa gcttgctata ggttattcca acatgcctta
    17161 cttcttgtcc ttcataatac ttatcaaaca agaaaagaca ataattctgc aattcctttg
    17221 tattatctgt gatagggatc ttcatctggt gtgaaaaccc tggtctcgtt tctaagatcg
    17281 acgtgccaat gtgtaaatgg acacaacctg ttttacagtt atgctgccta atgcgtatcg
    17341 ctacttgttc cgccatttct tttaccacca gctcgatttc atttcttcta gtataatctc
    17401 gtggtaacac ttgtgaattt ccatatgatt tttcctttgt cggttctggt gggattgcta
    17461 tatctgttcg atcgatccca ttagcatgga agtacagctg taagccaatc acacctagtc
    17521 tattcttaat cgtataagga ttccagttag caagatctct aatgctcata atccccatct
    17581 gattgagtct ttttttcatt cgagagccaa ttccccaaaa gtccgtcatt tcaggaatat
    17641 tccatacttt ttcaggaacg ttttcgtacg tccattccgc aacaaatcct tcattatgct
    17701 ttgcttcgtt gtctaaggct agtttagcca aaaggggatt atctccgaca cctactgtag
    17761 caatcaatcc tagctcttct ttaatattct cctggatcat ttgagccagc ttctttctcc
    17821 gttgacttcg tgttccttca gtcgtaaaaa gattcagtga tcgggtcact tttaagattg
    17881 attcatcgat cgagtaaatc agtagatctt catcagccac atatcttctg aaaatattat
    17941 ttacctgcat atttcgcttg atatataggt tcatacgtgg tggaacaacg tgtagtgttt
    18001 taggaaatgg ttgtggtaag tcacgtggtc tactcacatt tgtaatacca taccgctttt
    18061 ttgcttcagg agaagaagct aatatcaatc ctgaaccagt attatcagct cgactcataa
    18121 caacaagttc tgttgttaat ggatctaaat ttctttctat acattcgaca cttgcgtaaa
    18181 agcttttcat atcgattaaa aagtaatcat ttactggctc ttttgaataa tccatcataa
    18241 ataacactcc attctttcac attatacaaa catatgttcg atattgtaaa gaagaaatag
    18301 ctaaatacat aaaaaaagaa gcataggtat gctatcaccc tgcttcttct tttgatttgt
    18361 atgatcaatt tattctatca ctttactaat taatttgaaa atctaataaa aactctcact
    18421 ctaaaagagt gagagactgc aaattagagt acggactttt ttggagttcc gttctttaat
    18481 attaacaaat gaataaaatc cttacaacat ttgagaataa gttatcagta gacacttaca
    18541 aaaaattctc atactatttc ctccatcatt agtttttgtc tatataaggt ttaccctaaa
    18601 tagacactgg tataacattg aaaaatatgg cttcctcgtg tatgattagg gtgtatttta
    18661 aatagttgca gaaagtaggt aaaagttttg agagttgcat acatacgtgt ctcatcgatc
    18721 gatcaaaatg aacaacgcca gattgaagaa atgaaaaaat tcggtgcaga gagaattttc
    18781 atcgagaaac aatctggcgc aacgattact catcgacctg ttttccaaga agcattagat
    18841 tacgtccgag atcaagatat ttttattgtg gaagctattg atcgacttgg aagaaattat
    18901 gacgagatca tcgcttcagt caattacttg aagaagaaaa atgtgaagct gatcattact
    18961 agtttaccga tcatggctga agcaattggc aatcctctcc tggataaatt cattaaggat
    19021 ctgatcatcc aaattttggc catgatcgct gaacaagaac ggactgaatc gaaacgtcgc
    19081 caggcacaag gaattaagat cgcaaaagca aacggcgtct acaaagggcg gcccaaatta
    19141 tacagtgcag acgcaaaaga tccccaacgt cgccttgttt acaaaagcat cgttgaagat
    19201 cttaaaaatg gtgttgcgat tgctaagatt gctaaagact acaatgttac gagacaaacc
    19261 gtgtatagaa taaaaaaaga cagcatggtc aatgacaaat agttgatcat gctgctttta
    19321 ttatcttctc atctttaatt tcctacatat aattactatc tataaaatta agtcttactc
    19381 agaacagata aagcataaaa ttccaacaaa ccatttttta cttaactaaa taaagagtct
    19441 gttaatataa tcttcactta tttacgttaa tcccctactg tatttgttgg ttccttatct
    19501 atattttcta caaaatcctt attatcttgt gatttagctt cgtataattc tttgtatgtc
    19561 gacacattgg ttatactaat tcctatagct agttcttgag actctacttt tctctctagc
    19621 tcctttgaca aagtgatttg agatttattt ggttccgttg gagtcaattc tatagattct
    19681 tcataaaaat ctctatacat aaagctatcc ctgaataatt catagcttta attctttggc
    19741 acattttatt gaaatatgta tcactaatat ccctatcaac tgattttgac taaaaagtta
    19801 cttcaaacat tcactgttca aaaatattga ggaataaatt ttgggtgtaa ggcattttga
    19861 gcatacttct ccctggataa cttcccagta aaaaaatcgt tagattgttg gattagatcc
    19921 attgactggc tcgcctcagg cgagcaaaga ccctgtagaa ttcattctga tacacatgat
    19981 aactagataa tttgagatag actcgtctac ccgtttggac taatttccca gcaactttca
    20041 gaaacttcaa tcgaatagaa tgaatggtca ttcccttttg gacttcttca aagccaatcg
    20101 ttcttaagaa gttgactaag ttgtaagcta tcaagctgag catcattcgg acatgattct
    20161 ccaaaaagcg aggactgtct gttttgtcaa agtaaaagcc agctttcgct tctttaatga
    20221 agttctccat tgtgccacgt ttggcataga tagaaaagat ggtatcagga gaaacatttt
    20281 ctgatagatt cgtcacgata aattcatgtc gaaagagtag ttcgcccgct tcacgtgttg
    20341 agcgtataca cacgcgacga ctttgtgacc aggattgtgc ttgataagtg gtcgagaagt
    20401 actgaacttc tcgttcttcc cacttttgat tatcgccata aagtactgat ttctcagcta
    20461 tttgacctag tctacgatta ttcttcagtc gaataacata atgactcttt tttgattcac
    20521 acgaatcata cacaccaggt gtagcgaacc cgctgtctcc acgaaccaag atgtcagtgt
    20581 ttggtagaga gtgattatag tgctctaata aaggtgtgag aaactccttt acgccttttg
    20641 atgtatattg atttcctgaa cgtagttcag cttttaagaa gtcaccagtc aatccgtcaa
    20701 aagctaccaa tggatggtaa ccataggttt ggtagtgtgt attataattc gtttgttctt
    20761 ggtgaccaaa tgtatctgaa tgggtcgaat ctaaatcaat gattaattcc gtatcattac
    20821 ggatgaggcg tgctttatcg ataagttctt ggttcaaagc ttgaagttca tggatattct
    20881 cctcagatag tcgatctaaa aatcgggaaa gtgaagattg agaagcgagt tctttcctat
    20941 ctaaaacagc tttaaacaca ggatcttgtc tcaggagatt agctgcagaa tcagctgagt
    21001 aaccagcaat taattgcata atgaactgct caagtatgga taagttgtca tgagtaaaat
    21061 acgctcgttc gtcttcaatg tgaatgtgtt gcttagccag ttcagaaaaa ccaaagatgt
    21121 tcatcagctc tttcactagg acgagacccg aatcactcga taattgacca cctgtatgag
    21181 aaatagtgat atttgaattg aattttactt ggtttttgtg taagctagtc atgaaaagaa
    21241 ctcctttctt ttggttggtt tagtcacttt aaccatagca gaaaggggtt cttttttcat
    21301 cacttaacgg gtgaagatga aaaagtaatt gtaagctgcc gtgaggcagt ttcacatggt
    21361 tttaattaaa agtatgaatt attcaggcta tcattaattt tataaaaaaa attaaatgtt
    21421 tttagcactg ccatataaca ttcaaaacat tcttctatag ttggtttact tccttgagga
    21481 gaatgaacca atttattacg tttttctatg aaatttttaa tttcctttct tatttctttc
    21541 ggaaactcaa tattaaagta ccctttaaac atgctcccta ataatttgtc tacaggggga
    21601 gattgtaaat tctcaaatat tagagttaaa tcaggtttct cttgttgata aaattccttt
    21661 acccctattt cacaggctgt aattatcgaa ataaacctat ctctagtatt tgatatattt
    21721 ttacttcttt taaggagtat aagagaaaag gggatacttt cgtgtccatg catgtaatta
    21781 actaattgtt gagcttcaga agttatatct ctaattatat agttaacgga attaggaagt
    21841 gtctttaact ctaatgaaat ttctatccaa ttactatctt ctaatctgta tatgctcgaa
    21901 gtataatttg attcgtcagc aagcatcgct acatcccaaa cactgatcat aaaatctttt
    21961 aaacgttcaa tcatttcagc aatattgcta aaatcagcta atttttcttt agaataaaaa
    22021 aaacatttat atcagaatca ataaattcta ttttttttat tactatatcg tcatcattat
    22081 cttgaccatt tatgtttatt gttccctgag tggggagtac ttctttcaaa ttcaagttaa
    22141 atttatattc cattacttct cctccaatat ataaaaatta cttaactgta tccaaattta
    22201 atatgtaaat aaatcattaa tttttagcta aattctatga gaagtttatt tttgttgttt
    22261 ttgctaatta actaaaacta gtacaaaaaa tttaaaatag attattaaac ctattgctta
    22321 ttctattcag tcatatatat aagcgtcatc ctttagtaac taacatccca cactacaata
    22381 gtattataac atatctattc aacttcaaat tgttgaaatt taagccattt atatttactt
    22441 ttcctcaact ttagaaatga ttttactaac cttatatccg taatacgcgt aacaaacaca
    22501 ttcattaata acaatcaaca ctaagctata ttagcttttt aaatgactag ggtaaataaa
    22561 ataaggatca aaaactttta agtttctgac cctttcctta cttccgattg gttaatagtg
    22621 atcttttgca gaataaataa atatcgtttc attttcaact ctatatatca gtctatgttc
    22681 atctgtaatt cttctggacc attttccaga taaatcatgc tttaatggct caggttttcc
    22741 taatccagca aagggggaac gatcgatatc ttttattaac ttgttaatct tttttatatt
    22801 gcttttgttt ccttgctcat gccaataaag ataatcatcc caagcatcat cagaccaagc
    22861 cttaatcatc agattcaacc tcgattaagt catgtgtttt aaatgcacct ttggagaatt
    22921 gttcatctcc tcgacgaatt ttttccatga cgtaattatt agaaagtgtt ctcaacgttt
    22981 cttgcataga atcataatct ctttttgata atacaacaac tgtatcttct acatctttac
    23041 ttgttacaat aagtgtttca gcatcctcat taacttgttt catataacta cgtaaatttt
    23101 ggcggaaatt tgaataagct actgcttcca ttcctttcac cccttattta tttctataaa
    23161 acaattgtac attatattgt acaattaagc aaatgattaa tattctaact tcttataatt
    23221 aaaagtgcta tcacttttag tttttaggat aaaaagtgac gtcacttttt gagtgctggt
    23281 acctcaaatc ctgctttttc ttgggcaatc aataaatcta acgcaataca cataatcctg
    23341 gattcacttt tgccgtactt ctgctttagt tgctgcaatt ctttttgtct cttttcatcc
    23401 aacgtaacgg gtaaccgttt atttcctatt gcaattggca ttagtactct ctcctttcat
    23461 cgaaataacc ctatgaaaaa tatggctgca atcatcttga atagtagact cacaagggct
    23521 aatacaaagc gccaaaagat caaacaaaat accagtattg ccaaaaatac tacgaagttt
    23581 aaatgcacag ctgcagcatg gcgcataagt atttcgccaa caaataggac taacaataga
    23641 ggaatgattt tattcatatg gatctccttc tttctcttag gttatcgggt gttgcccgct
    23701 tatttcgcac cacctaagcg gcgggggcgg ttggagcgat tggtgcgaaa taagaaccat
    23761 tcccttagtt actaggtttt ttgtccttat ttcacacatt ctcacttttc ggtataaatg
    23821 attattgcct ttttttcctt tcaaatcgtt gatatggcat tcgtttacgg tcaagttcat
    23881 tttggatttc ttctgtatcg tcgtaagtat aggtgtctaa aaaatcagtt aaagtcgtgt
    23941 accagtcgtc gcctgggtta tctacttctt ctacatattc cctcaaaaat gcttcgggta
    24001 cagcgagttc ataatccatt cccattaaca cgatagattc cgttccacac gtcaaaaatc
    24061 tagtaaatac aaggtaataa tcgtctatcg tcgcatcttt gctgtttagc tcttccattt
    24121 cttcttccat taattccatg ctctcaaaaa ttgaataata ttctgattct gagtaatagt
    24181 gtttcctgca aatcgtgtag ctgacaaagt tttcgaccag ctcactcctt tctaggtaaa
    24241 cattcatgat gtatttttct gtttctagtc gtagaagctc cgttcctttt tttaccgttt
    24301 caggacgacg tttatacacg tctaaacgat tatggctgac tgtgaccttc gtttgactcg
    24361 tttcactttc caaatacaat tgttcttcgg gttctgttgc aaagttttaa atctactatc
    24421 aaataaggta gaataataga aaaagatagc aggaggaatg acgatgaatc attttaaagg
    24481 aaagcaattt cagcaggatg tgattattgt agccgtgggc tactatcttc gttataacct
    24541 tagctatcgt gaagttcaag aaatcttata tgatcgtggc attaacgttt ctcatacgac
    24601 gatttatcgt tgggtgcaag aatatggcaa actactctat caaatttgga aaaagaaaaa
    24661 taaaaaatcc ttttattcat ggaaaatgga tgaaacgtac atcaaaatta aaggaaaatg
    24721 gcattatttg tatcgagcca tcgatgcaga tggtttaacc ttggatattt ggttacgtaa
    24781 aaaacgggac acacaagcag cctatgcttt tcttaagcgg ttagtgaagc agtttgatga
    24841 accgaaggtt gtagtcacag ataaagcccc ctctattaca agtgccttta agaaactaaa
    24901 agaatacggc ttttatcaag ggacagaaca tcgtaccatt aaatacctga ataatttgat
    24961 tgaacaagac catcgtccag taaagagacg caataaattc tatcgaagtt tacgcactgc
    25021 ctctaccacg attaaaggca tggaagccat tcgaggatta tataagaaaa cccgaaaaga
    25081 aggcactctc ttcgggtttt cggtctgtac tgaaatcaag gtattattgg gaatcccagc
    25141 ttaaatcata gataccgtaa gggattttat tctttattta aaactttgca acagaaccat
    25201 tccgtttttt catccattcc tttcttcccc ccttacaaat aaataataac ctttaacaac
    25261 caactcgtaa ataggttggt tgttattata caaaaggata ttagtactca gataaaaagt
    25321 tgttagtact cagataaaaa gttgttagta ctcagataaa aagttgttag tactcagata
    25381 aaaagttgtt agtacccttc tgtatccgtt gggagagtaa ggctcaactg ccccctaaaa
    25441 agggttctaa aaaatcttta aaaaataaat aaaataaacg cgcgcgcgcg agcaaaattt
    25501 cccgccaaaa aatcacccac tttttaaaat aaacaggttc gcgcatgata ttaaactgcc
    25561 aatctagctc cctatggtcg ctgtaagaag gagtgatcgc tacgctctca cattttactt
    25621 gcagcagtcg cctttaggct ccttcgccaa aaataattca ttagggactc ctttgtggcg
    25681 tcctgagagc tcgtctaagc cgttctaaga caagattcga taaaaactat gtccttcgtt
    25741 ctaaagcgcc ttacaggcgg tcagggcaag ccctaacaac cccaaggcaa taaaaaactt
    25801 aggcttattt ttgctttttt attgtataat tgattgtcgc ctatccgaca gtcttgcgac
    25861 tggaaggagg tgtgtttcgt gttcactaac tttatttgct cccttcttgt tgggctttta
    25921 agcgctttgt tcagttactg gttgaataac cgaaacaaga agtaaaactt aattaaggcg
    25981 actcagccca caaaaaaagc cccagagaat ccgacctctc tggggctttc gtgtgtttcg
    26041 tgttcactta tttgcaatca aattataaca gaaataaata tttatttcaa aaatatccta
    26101 caaaagtcta aaatccgtaa ttatttctta tatgcaacat ttacaaataa agtcgctctg
    26161 agagctcgta tttttcgatt taagacgttt tatttagttt ttggtgtatt tcattggtcc
    26221 aagctaaaaa actcttagaa gcgattttag agccatttaa acccacttaa ttatattctc
    26281 catgaaattc gctccatgcg tcaaaagctg cgtctgaaat tccgccgtct tcgttcacta
    26341 gttgcattaa tttttccaac gatcgttttc tttcgggtgt catattttta tattccaaca
    26401 atttttcgtc tgttaaatcg aacttgattg cttgaattgc ttgctctaat ttttctaagt
    26461 tttgaaaata ttcgtaagga aatttttcca ttttttcttt ctccagtctc acaatttttc
    26521 tagaaataaa atcacttctt tgccgtctat actctcaaaa aaaatgtcgt ttgaaaaact
    26581 aaataaattt ttgatcgtgc atttttaaat ttggttatcg attacacgtg cagcactccc
    26641 ccccgaattt taaagagcat aaggaaacgt gtacccactt tctaaaaaaa gtgggtagat
    26701 aggctgtgcc tatcacgttt ctcagaaaaa aatttgatat cactttttcg ccatcgtggg
    26761 tagcttatgt atagcatttt ggcaaaaaac agctatacaa atatagtatt tgtatggtat
    26821 acataaatta tacataattg caaaaggaga ttttttatgg acattttagt tcggaatatt
    26881 gatccaaagt ttgttgcaac aatagacaaa cgttgccaag aactcacgaa taaaacagga
    26941 gaaaaatgga gtcgaaataa atatctaaaa gttttaatcg aaagtgattt tgaccgtcaa
    27001 cttacgactt acaaaaaaga ccaattcgat ttattgctcg ataaatttat tgctatccaa
    27061 acagaaaata ctcaaatatt aagcgagtat gtctacacaa ataatcaaat cattgaaatg
    27121 cttatcggag gaatataaca tgagaaaaac ttctgtccaa aaacatgtta ctttgtaccc
    27181 tagtcatgtt gacgttttag attccatcat cgaaaaaaat ccagatatca ataactactc
    27241 ggaagccatt cgctttttat gtatgagtta tgaacccgat accaacacga ccactaccag
    27301 caatcaggca aaactaaatg ctatgggaaa agaaatttcc atcatgactg aaatcatcgc
    27361 agaatttgct gatttatatc taaaagatac aggcgttctt attggcacaa attctaaagt
    27421 atatcaagaa gtgaaagaaa aaatcgaagc taaactaaat ccatcaaatc gaaatcgacc
    27481 aaagaatcat caaaaagaaa ccagtcaaac agtcacttct agaaatttcg acccaacaaa
    27541 ttttctaaaa cgataaaaaa cagataggag ttattcctat ctgtttttta tttagaagcc
    27601 ccatacaata tgctagaatg tactagcaat cttagtcggt tgtaagggac ttgtctactt
    27661 gcttaatgta aggggggcga gttctttttt atttattctt ctaaccagtt acgcagagaa
    27721 atctttggca aatctgacgt taggcttgaa aaagtaaatt ctaatttggc gattttattg
    27781 cccttttttg cttttatttt tgtgacttta agatcattga agtatttttt tagttctcgt
    27841 aatgcaggat ttaatacttt ttgatcaatg ttacccattt gatagtattc tgggatatcc
    27901 attaagctcc taaactcttc aatacgaact acataataac cagtagaacg gtactgcata
    27961 agcagtcgga atagagtttt tgcatacgta gaacgcaacg acgtgaaagc agataattca
    28021 aatctactaa attcagctgt taaaccatta ataatatatt ctaggtccgg attaacactg
    28081 acttcaacaa acttttttgt tttattgatt tcaaaaccag taaacaaaac aaagtagcga
    28141 atagaatcct catcttcagt acggtaagta agattaagca tatctttata gagcttttct
    28201 aaatcaccga caaaggcttt tgtagcagtc atcttataat cacttaactc ttttaattcc
    28261 tcgaaagaaa atctaacttt tttcaaacca cgatctttca tacgagcgca taatgcaaaa
    28321 aataaatcca tctgcttagc attgaaattt ttcagcggta ctaaattcaa ttcattttga
    28381 tatttgactg ttaattccgt tg
//
