LOCUS       NZ_CP059743            24162 bp    DNA     circular CON 01-OCT-2023
DEFINITION  Enterococcus faecium strain A4694 plasmid pA4694_P4, complete
            sequence.
ACCESSION   NZ_CP059743
VERSION     NZ_CP059743.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN14675385
            Assembly: GCF_012933245.2
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 24162)
  AUTHORS   Veeraraghavan,B., Vasudevan,K., Arumugam,A., Solaimalai,D. and
            Bakthavatchalam,Y.D.
  TITLE     Complete genome of vancomycin resistant Enterococcus faecium
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 24162)
  AUTHORS   Veeraraghavan,B., Vasudevan,K., Arumugam,A., Solaimalai,D. and
            Bakthavatchalam,Y.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2020) Clinical Microbiology, Christian Medical
            College, Ida Scudder Road, Vellore, Tamil Nadu 632004, India
REFERENCE   3  (bases 1 to 24162)
  AUTHORS   Veeraraghavan,B., Solaimalai,D., Vasudevan,K. and Arumugam,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-APR-2020) Department of Clinical Microbiology,
            Christian Medical College and Hospital, Ida Scudder Road, Vellore,
            Tamil Nadu 632004, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2020
            Assembly Method :: CANU v. v. 1.7; UNICYCLER HYBRID v. v. 0.4.6
            Assembly Name                     :: A4694
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 91.24x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 10/01/2023 03:42:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,020
            CDSs (total)                      :: 2,928
            Genes (coding)                    :: 2,815
            CDSs (with protein)               :: 2,815
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 113
            CDSs (without protein)            :: 113
            Pseudo Genes (ambiguous residues) :: 0 of 113
            Pseudo Genes (frameshifted)       :: 38 of 113
            Pseudo Genes (incomplete)         :: 69 of 113
            Pseudo Genes (internal stop)      :: 30 of 113
            Pseudo Genes (multiple problems)  :: 20 of 113
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059743.1.
            Bacteria and source DNA available from Christian Medical College.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..24162
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="A4694"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="pA4694_P4"
                     /geo_loc_name="India:Vellore"
                     /lat_lon="12.9165 N 79.1325 E"
                     /collection_date="2019"
                     /collected_by="CMC Vellore"
     gene            complement(join(24088..24162,1..612))
                     /locus_tag="HI848_RS14640"
                     /old_locus_tag="H4J15_014640"
     CDS             complement(join(24088..24162,1..612))
                     /locus_tag="HI848_RS14640"
                     /old_locus_tag="H4J15_014640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_059355960.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLW
                     LFVNKD"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(666..884)
                     /locus_tag="HI848_RS14645"
                     /old_locus_tag="H4J15_014645"
     CDS             complement(666..884)
                     /locus_tag="HI848_RS14645"
                     /old_locus_tag="H4J15_014645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002347151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002347151.1"
                     /translation="MNNKNTKNTNTNHEKRSFFDKLFKKKKNGKVSILKMIGWIFLAFF
                     IVAVNSSGGDKKEAASKDTTKGSVAKF"
                     /name="hypothetical protein"
     gene            complement(932..1204)
                     /locus_tag="HI848_RS14650"
                     /old_locus_tag="H4J15_014650"
     CDS             complement(932..1204)
                     /locus_tag="HI848_RS14650"
                     /old_locus_tag="H4J15_014650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002303415.1"
                     /translation="MLGSFKKDKEVKTRGALTPSQQNKLGTKATFHPVRDQANQKELIG
                     VCVGFTSEKFFPIIECKIHGITTREVARKVVKWHTSQTKTNHKKR"
                     /name="hypothetical protein"
     gene            complement(1194..1403)
                     /locus_tag="HI848_RS14655"
                     /old_locus_tag="H4J15_014655"
     CDS             complement(1194..1403)
                     /locus_tag="HI848_RS14655"
                     /old_locus_tag="H4J15_014655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002303414.1"
                     /translation="MIRKLNNIKLSLAILTLFFGIYNNSRMALFFLTLLIFMNLIIHNF
                     KELENTAPAPSQGNQESEGMPHAW"
                     /name="hypothetical protein"
     gene            complement(1534..1812)
                     /locus_tag="HI848_RS14660"
                     /old_locus_tag="H4J15_014660"
     CDS             complement(1534..1812)
                     /locus_tag="HI848_RS14660"
                     /old_locus_tag="H4J15_014660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002303413.1"
                     /translation="MEKKEDLLNAFKNLDEKDQLKALLRLHDITYSDIAERLTVKKGER
                     EGQKGVSLVTVQKAFQSKTNLESDRWKEIVKVATKLIEERQNDQNKA"
                     /name="hypothetical protein"
     gene            complement(2117..2425)
                     /locus_tag="HI848_RS14665"
                     /old_locus_tag="H4J15_014665"
     CDS             complement(2117..2425)
                     /locus_tag="HI848_RS14665"
                     /old_locus_tag="H4J15_014665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002303412.1"
                     /translation="MKEMKMKQVIYPVIIGVLAIALIILGVNCYNLSKENNQLETKNNK
                     QEIQIAKQAYVISDYKTYFRENYVDTVKYRSHFTDKQILNVYREALRDGKISDEGAN"
                     /name="hypothetical protein"
     gene            complement(2599..2967)
                     /locus_tag="HI848_RS14670"
                     /old_locus_tag="H4J15_014670"
     CDS             complement(2599..2967)
                     /locus_tag="HI848_RS14670"
                     /old_locus_tag="H4J15_014670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002347150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002347150.1"
                     /translation="MENTNQTPNTAPTNQTSPAERKADLIRLYSRLEGMKLQHVPTAPK
                     APDGFPKSAESLEFFECKVCGSTFQTILRESVASGCPKCEHDRLGILADHLPEPDKNSC
                     LNNRKKPVTVMAMGFLCI"
                     /name="hypothetical protein"
     gene            complement(3081..3698)
                     /locus_tag="HI848_RS14675"
                     /old_locus_tag="H4J15_014675"
     CDS             complement(3081..3698)
                     /locus_tag="HI848_RS14675"
                     /old_locus_tag="H4J15_014675"
                     /inference="COORDINATES: protein motif:HMM:NF013235.3"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_182482101.1"
                     /translation="MELLQTGINLHSIYMVDENENEIITAPAIARWVINKHTLEVTARI
                     NPEYLEWFSEVVNQYILFNLRDFVKLKSKYSMILFLELSTFWNTGMYYKRINDLREILG
                     VNPTRNNRDFINNVLKPAIAALKEYFPELSLTVEKNSSDSRKITHVRLKFDKLTITDMQ
                     ERLRSSEGASLVEYQQELENMEGEEKAVNDPTPEIDLSNVEW"
                     /name="replication initiation protein"
     gene            3837..4517
                     /locus_tag="HI848_RS14680"
                     /old_locus_tag="H4J15_014680"
     CDS             3837..4517
                     /locus_tag="HI848_RS14680"
                     /old_locus_tag="H4J15_014680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            4715..5320
                     /locus_tag="HI848_RS14685"
                     /old_locus_tag="H4J15_014685"
     CDS             4715..5320
                     /locus_tag="HI848_RS14685"
                     /old_locus_tag="H4J15_014685"
                     /EC_number="2.7.7.108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016176895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein adenylyltransferase Fic"
                     /protein_id="WP_000599739.1"
                     /translation="MILENKLGLTNQVELAKVEEKLSKQKAKELYDCGKINEIEVGTFK
                     GLSEIHEFLFSDIYDFAGKIRSVNIAKGNFRFAPVMYLEHSLQHIDQMPQTSFEEIIKK
                     YVEMNIAHPFREGNGRSTRIWLDLILKEELQKVVDWNLIDKADYLSAMERSPINDLEIR
                     YLISNALTDKIDDRELYMKGIDVSYFYEGYSEYTIDDL"
                     /name="protein adenylyltransferase Fic"
     gene            5336..5908
                     /locus_tag="HI848_RS14690"
                     /old_locus_tag="H4J15_014690"
     CDS             5336..5908
                     /locus_tag="HI848_RS14690"
                     /old_locus_tag="H4J15_014690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170424.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_002303206.1"
                     /translation="MTKYGYARVSTASQSTKEQIQQLLENCVEKKNIFSEKFTGTKRDR
                     PKFNQLLAGLKPGDEIVVTKLDRFARNTREALEIIEPLLDDNVTIKVLNLGTIENTSMG
                     RMVTRTLLSVAEMERDMIVERTQEGKMFARKNNPNFREGRPKATITPKKRHAYELLTSG
                     KSYKEVEAITGFSRSTLFRIKKKIEES"
                     /name="recombinase family protein"
     gene            complement(6381..6953)
                     /locus_tag="HI848_RS14695"
                     /old_locus_tag="H4J15_014695"
     CDS             complement(6381..6953)
                     /locus_tag="HI848_RS14695"
                     /old_locus_tag="H4J15_014695"
                     /inference="COORDINATES: protein motif:HMM:NF033516.0"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="WP_073120187.1"
                     /translation="MCQKNCCHSIISKENLLNQDFSTETICEKWAADITYIPTKKNGWC
                     YLSSIMDLHTKRIISYTFSKRMTVDCVIQTLNKAKIHYHIPEGMILHTDLGSQYTAREV
                     EQWLKTNKIRHSYSRKGTPYDNAGIESFHASLKKEEVYTTSYSDFEEANRALFSYIEGF
                     YNRNRIHSSIHYLTPQEFEELAKEKMA"
                     /name="IS3 family transposase"
     gene            complement(7054..8216)
                     /locus_tag="HI848_RS14700"
                     /old_locus_tag="H4J15_014700"
     CDS             complement(join(7054..7940,7940..8216))
                     /locus_tag="HI848_RS14700"
                     /old_locus_tag="H4J15_014700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611768.1"
                     /ribosomal_slippage=""
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="WP_127817621.1"
                     /translation="MSKRTRRTFSQEFKQQIVNLYLAGKPRVEIIREYELTASAFDKWV
                     KQSKTSGSFKEKDNLTPEQKELLELRKRNQQLEMENDILKQAALIFGPKRQVIDANKHL
                     YPISAMCRILGLSRQSYYYQSKPKKDESELEEVVAEEFIRSRKAYGSRKIKKALSKRGI
                     QISRRKISRIMKNRGLKSSYTVAYFKVHHSTCNEAKTTNVLNRKFLRDNPLEAIVTDLT
                     YVRVGKKWNYVCFILDLFNREILGYSCGEHKDAVLVKKAFSRIKQPLTEVEIFHTDRGK
                     EFDNQAIDELLTTFDINRSLSHKGCPFDNAVAESTYKSLKVEFVYQYTFETLQQLDLEL
                     FDYVNWWNHLRLHGTLGYETPVGYRNKRLAQRILDNELGCANASEAV"
                     /name="IS3 family transposase"
     gene            complement(8622..8876)
                     /locus_tag="HI848_RS14710"
                     /old_locus_tag="H4J15_014710"
     CDS             complement(8622..8876)
                     /locus_tag="HI848_RS14710"
                     /old_locus_tag="H4J15_014710"
                     /inference="COORDINATES: protein motif:HMM:NF013677.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0004803 - transposase activity [Evidence IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="WP_000199136.1"
                     /translation="MTRYEENFKQMIVELNQTGRSVRGLAKEYGLSEATIYKWKNLYLP
                     DQSTGLTGKEVAELRKENARLNEELEILKKAAAIFSRKT"
                     /name="transposase"
     gene            complement(9069..9344)
                     /gene="prgO"
                     /locus_tag="HI848_RS14715"
                     /old_locus_tag="H4J15_014715"
     CDS             complement(9069..9344)
                     /gene="prgO"
                     /locus_tag="HI848_RS14715"
                     /old_locus_tag="H4J15_014715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA segregation protein PrgO"
                     /protein_id="WP_001196543.1"
                     /translation="MALLPTNKDKKKIGAEDISIKDDINVELGERKYTAKERKPVQVDP
                     PVLKTIRDLSYAKDIPMYEIVKLAMDAYVDTLNDEERIIYNRRSKD"
                     /name="prgO"
     gene            complement(9316..10269)
                     /locus_tag="HI848_RS14720"
                     /old_locus_tag="H4J15_014720"
     CDS             complement(9316..10269)
                     /locus_tag="HI848_RS14720"
                     /old_locus_tag="H4J15_014720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016623100.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="WP_000429439.1"
                     /translation="MENLRTAFKTSDKLGKVVMLTGRKGGIGKTTDNDLLAIVSSQLFE
                     KDVLLIDYDQQRNTTSNIGSTYQITSFDRSMSAAIKKGDWVSGITQVSPHLYIMAGSPG
                     SEELNEYLSEKYPDRRKRSLAFIKPLEELRKNFDYIFIDCPPSTDNVVRAFLTAADYII
                     AMQELKRYAMEGTEDFINKVLVPIVTNFEESHLQIIGILPVLFSVRRSSQHANYQKTID
                     KYGESNIFKSIVKGSDRLEMYGENGIQLNDYVDRRWWAIFADIFTELEERIEYYEQHGD
                     IEGFDYTPKYADSMANHILPLGKEIKLNGIITNEQR"
                     /name="ParA family protein"
     gene            10881..12374
                     /locus_tag="HI848_RS14725"
                     /old_locus_tag="H4J15_014725"
     CDS             10881..12374
                     /locus_tag="HI848_RS14725"
                     /old_locus_tag="H4J15_014725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000947690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primase C-terminal domain-containing protein"
                     /protein_id="WP_000947691.1"
                     /translation="MLSEIYSAILKNGLRTYKYRNSTMKPAGHIDSSRSGAIFAYRSKQ
                     LMNVGRGMVITSEEAILENEKKLTHWTPNTYRFGTYADDYRTVVKGHSEKNLSQINTFV
                     VDIDSKENHQGEIILACLDQVGYMPTLILESDHGYQVYFVLKTPGYVTKKSNFKVIDVA
                     KKISKTIRLQLAEKLSGVDLGCNHFGIARFPQENNIVFKEMNYQYSFADWIQWSMKLES
                     DQKTKEDRERKLIVFPEKKEIRQVDEPWFDMLLHKANIVGGEGRLGRNNVIFTLSLAYY
                     SSGYALDTCEYNMFTFNERLQEPLSEAELVKIVRSAYSGNYQAASREFIIELCQQWVSP
                     TLKNNDLFIQRRGWWKFKKPRDQRKYSHKNEWKEDLLAYLSEKSLASEPYLNLSKKELA
                     SQLTMPKRTLDKILNELREENKVFYKVTRGRNGGMIIASVKTLFARVIQLSKEKRLDYS
                     TRITEVFGLNESLVEETFRQLSTPLNPLKEVNLFEVDTG"
                     /name="primase C-terminal domain-containing protein"
     gene            12509..12805
                     /locus_tag="HI848_RS14730"
                     /old_locus_tag="H4J15_014730"
     CDS             12509..12805
                     /locus_tag="HI848_RS14730"
                     /old_locus_tag="H4J15_014730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication control protein PrgN"
                     /protein_id="WP_000053907.1"
                     /translation="MSLKNYVYSHPVNVFIIGRLGLSVEVFCELYGFKQGTLSSWVTRE
                     KTVASLPIEFLHGLSLASGETMDQVYDCLCVLEQEYIEYKIANELRKRKKYIQ"
                     /name="replication control protein PrgN"
     gene            complement(12829..13788)
                     /locus_tag="HI848_RS14735"
                     /old_locus_tag="H4J15_014735"
     CDS             complement(12829..13788)
                     /locus_tag="HI848_RS14735"
                     /old_locus_tag="H4J15_014735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002339652.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="WP_002287225.1"
                     /translation="MTYTHLTTDELVMIESYFKINQSVAKTAHFLNRSRQTIHKVYLFF
                     KQGKSALEYYQQYKKNKSNCGRRPLVLPEEQSEYIQRKVVQGWTPDVIVGRAAFPIRCS
                     ARTIYRMFKKGLFNPSDLPMKGKRKPNGHQERRGKQAFRRSIHEREKDYSQFSNEFGHL
                     EGDTIVGLKHKSAVITLVERLSKVIITLKPCGRQAIDIENKLNHWFESVPKNLFKSITF
                     DCGKEFSNWKQISNANDIAIYFADPGTPSQRGLNENSNGLLRRDGLLKSMDFNSVDESF
                     IQSVASKRNNIPRKSLNYRTPLEVFLSYVSIDDLSNLI"
                     /name="IS30 family transposase"
     gene            complement(14060..14740)
                     /locus_tag="HI848_RS14740"
                     /old_locus_tag="H4J15_014740"
     CDS             complement(14060..14740)
                     /locus_tag="HI848_RS14740"
                     /old_locus_tag="H4J15_014740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(<14815..>15447)
                     /locus_tag="HI848_RS14745"
                     /old_locus_tag="H4J15_014745"
                     /pseudo=""
     CDS             complement(<14815..>15447)
                     /locus_tag="HI848_RS14745"
                     /old_locus_tag="H4J15_014745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011117014.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="tetracycline resistance ribosomal protection
                     protein"
                     /name="tetracycline resistance ribosomal protection
                     protein"
     gene            15523..16203
                     /locus_tag="HI848_RS14750"
                     /old_locus_tag="H4J15_014750"
     CDS             15523..16203
                     /locus_tag="HI848_RS14750"
                     /old_locus_tag="H4J15_014750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            <16260..16760
                     /locus_tag="HI848_RS14755"
                     /old_locus_tag="H4J15_014755"
                     /pseudo=""
     CDS             <16260..16760
                     /locus_tag="HI848_RS14755"
                     /old_locus_tag="H4J15_014755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010868911.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /name="IS6-like element IS1216 family transposase"
     gene            <16816..17073
                     /locus_tag="HI848_RS14760"
                     /old_locus_tag="H4J15_014760"
                     /pseudo=""
     CDS             <16816..17073
                     /locus_tag="HI848_RS14760"
                     /old_locus_tag="H4J15_014760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002355409.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome partitioning protein ParA"
                     /name="chromosome partitioning protein ParA"
     gene            17165..17380
                     /locus_tag="HI848_RS14765"
                     /old_locus_tag="H4J15_014765"
     CDS             17165..17380
                     /locus_tag="HI848_RS14765"
                     /old_locus_tag="H4J15_014765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002401482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-binding protein"
                     /protein_id="WP_001835296.1"
                     /translation="MIVGNLGAQKAKRNDTPISAKKDIMGDKTVRVRADLHHIIKIETA
                     KNGGNVKEVMDQALEEYIRKYLPDKL"
                     /name="peptide-binding protein"
     gene            17397..17669
                     /locus_tag="HI848_RS14770"
                     /old_locus_tag="H4J15_014770"
     CDS             17397..17669
                     /locus_tag="HI848_RS14770"
                     /old_locus_tag="H4J15_014770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002333002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin"
                     /protein_id="WP_000301765.1"
                     /translation="MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVN
                     LLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA"
                     /name="antitoxin"
     gene            17671..18534
                     /locus_tag="HI848_RS14775"
                     /old_locus_tag="H4J15_014775"
     CDS             17671..18534
                     /locus_tag="HI848_RS14775"
                     /old_locus_tag="H4J15_014775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010782381.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016301 - kinase activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zeta toxin family protein"
                     /protein_id="WP_001284311.1"
                     /translation="MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSG
                     KTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELVKLYEKDVVKHVTPYSNRMTEAIIS
                     RLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYETMY
                     ADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISP
                     KETLEKELNRKVSGKEIQPTLERIEQKMVLNKHQETPEFKAIQQKLESLQPPTPPIPKT
                     PKLPGI"
                     /name="zeta toxin family protein"
     gene            complement(18797..19534)
                     /gene="erm(B)"
                     /locus_tag="HI848_RS14780"
                     /old_locus_tag="H4J15_014780"
     ARG             complement(18801..19534)
                     /name="erm(B)"
                     /gene="erm(B)"
                     /gene_name="23S rRNA (adenine(2058)-N(6))-methyltransferase
                     Erm(B)"
                     /tool="amrfinderplus"
                     /drug_class="LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN"
                     /identity="99.59"
                     /coverage="100.0"
     gene            complement(19659..19742)
                     /locus_tag="HI848_RS14785"
                     /old_locus_tag="H4J15_014785"
     CDS             complement(19659..19742)
                     /locus_tag="HI848_RS14785"
                     /old_locus_tag="H4J15_014785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA methyltransferase attenuator leader
                     peptide ErmL"
                     /protein_id="WP_031929417.1"
                     /translation="MLVFQMRYVDKTSTVLKQTKNSDYADK"
                     /name="23S rRNA methyltransferase attenuator leader peptide
                     ErmL"
     gene            complement(19791..>19874)
                     /locus_tag="HI848_RS15315"
                     /old_locus_tag="H4J15_014790"
                     /pseudo=""
     CDS             complement(19791..>19874)
                     /locus_tag="HI848_RS15315"
                     /old_locus_tag="H4J15_014790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000502600.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MLS leader peptide"
                     /name="MLS leader peptide"
     gene            complement(20031..20990)
                     /locus_tag="HI848_RS14795"
                     /old_locus_tag="H4J15_014795"
     CDS             complement(20031..20990)
                     /locus_tag="HI848_RS14795"
                     /old_locus_tag="H4J15_014795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002339652.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="WP_002303350.1"
                     /translation="MTYNHLTPTELVMIEAYFNQSQPVSKVANLLQRSRQTIYKVYRFL
                     KSGGSAMSYYKQYKKNKRNCGRHPIVLPDEQQEYIQKKVVQGWAPDVLIGRAEFPIACS
                     VRTLYRMFKDKTFDTHDLPMKGKRKPNGHKEKRGKQGFRRSIRDRKTDYTQFDHEFGHL
                     EGDTIVGGKHKSAVITLVERLSKVIITLKPEGRQAKDIENRLNQWFRCVPKNLFKSITF
                     DCGKEFSNWKKISNTNDISIYFADPGTPSQRGLNEHSNGLLRKDGLYKAMDFNGVSETF
                     IQSVASKRNHIPRKSLHYRTPMEVFLSYVTKDDLSNLI"
                     /name="IS30 family transposase"
     gene            complement(21350..22144)
                     /gene="aph(3')-IIIa"
                     /locus_tag="HI848_RS14800"
                     /old_locus_tag="H4J15_014800"
     ARG             complement(21354..22144)
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(22237..>22488)
                     /locus_tag="HI848_RS14805"
                     /old_locus_tag="H4J15_014805"
                     /pseudo=""
     CDS             complement(22237..>22488)
                     /locus_tag="HI848_RS14805"
                     /old_locus_tag="H4J15_014805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000627290.1"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /name="GNAT family N-acetyltransferase"
     gene            22733..24028
                     /locus_tag="HI848_RS14810"
                     /old_locus_tag="H4J15_014810"
     CDS             22733..24028
                     /locus_tag="HI848_RS14810"
                     /old_locus_tag="H4J15_014810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3-like element ISEfa11 family transposase"
                     /protein_id="WP_002297218.1"
                     /translation="MNDSIKKMLRITEKDLMITEVSYETLQKKKTLVVDAVLSPTPRAC
                     RSCGSTVVDGNGKAIIVKNGKKETIVRFEQYNHMPLVMRLKKQRYTCKNCRTHWTAQSY
                     FVQPRHSIANHVRYKIASLLTEKVSLSFIAKSCQVSLTTVIRTLKEFKSYLPKQSKKIL
                     PRVLMVDEFRSHASIEDKMSFICADGETGKLIDVLPTRKLPRLTSYFLGCTNPEEVEFL
                     VTDMNAAYFQLTKRVLPNAKVVIDRFHIVKHMNQAFNELRIREMNELRKAGQKSQAEKL
                     KKNWRFLLKNRANINHYEYKTWKSFRAPKYPFLTEAMMIDRLLEFSPPLKEAYPFFHEL
                     VEAFRDKDPDLFFSLLAELPETLDDSFREKLQNLLTYEEGITNAMIYPYSNGKIEAKNT
                     HIKTMKRVSYGFKSFENMRIRIFLINQLINVR"
                     /name="ISL3-like element ISEfa11 family transposase"
     ARG             complement(14795..15399)
                     /name="tet(M)"
                     /gene="tet(M)"
                     /gene_name="tetracycline-resistant ribosomal protection
                     protein"
                     /tool="rgi"
                     /drug_class="tetracycline antibiotic"
                     /identity="95.02"
                     /coverage="31.46"
     ARG             complement(18798..19534)
                     /name="ErmB"
                     /gene="ErmB"
                     /gene_name="Erm 23S ribosomal RNA methyltransferase"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; lincosamide antibiotic;
                     streptogramin antibiotic; streptogramin A antibiotic;
                     streptogramin B antibiotic"
                     /identity="98.78"
                     /coverage="98.79"
     Typing          10882..12374
                     /name="rep_cluster_185"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 tcgggttttc ttatataatc ctcgaatggc ttccatgcct ttaatcgtgg tagaggcagt
       61 gcgtaaactt cgatagaatt tattgcgtct ctttactgga cgatggtctt gttcaatcaa
      121 attattcagg tatttaatgg tacgatgttc tgtcccttga taaaagccgt attcttttag
      181 tttcttaaag gcacttgtaa tagagggggc tttatctgtg actacaacct tcggttcatc
      241 aaactgcttc actaaccgct taagaaaagc ataggctgct tgtgtgtccc gttttttacg
      301 taaccaaata tccaaggtta aaccatctgc atcgatggct cgatacaaat aatgccattt
      361 tcctttaatt ttgatgtacg tttcatccat tttccatgaa taaaaggatt ttttattttt
      421 ctttttccaa atttgataga gtagtttgcc atattcttgc acccaacgat aaatcgtcgt
      481 atgagaaacg ttaatgccac gatcatataa gatttcttga acttcacgat agctaaggtt
      541 ataacgaaga tagtagccca cggctacaat aatcacatcc tgctgaaatt gctttccttt
      601 aaaatgattc atcgtcatta ctcctgctat ctttttctat tattctacct tatttgatag
      661 tagatttaaa actttgcaac agaacccttt gtggtatctt ttgaagcagc ctctttctta
      721 tcaccgccgc tactgttcac agcaactatg aaaaaggcta aaaatatcca gccgatcatt
      781 ttcaaaatag atacttttcc attcttcttc tttttgaaaa gcttatcaaa gaagcttctc
      841 ttctcgtggt tagtattggt atttttggtg tttttgttgt tcattcttaa atctccctta
      901 atttaatttt caaacgctct taggaacgtt tttaacgttt cttatggttg gttttggttt
      961 ggctggtgtg ccatttcaca acttttctag caacttctct agttgtgatc ccgtgtattt
     1021 tgcactctat tattggaaaa aatttctctg aagtaaaccc tacacaaacg ccaattagtt
     1081 ctttttggtt ggcttgatct cggacggggt ggaaagtggc ttttgtacca agcttatttt
     1141 gctggcttgg tgtaagggct cctcgtgttt ttacttcctt atccttttta aaactaccaa
     1201 gcatgtggca tgccctcact ttcttggttt ccttgagagg gcgctggagc tgtattttct
     1261 aactccttga aattatggat aattaagttc atgaatatca ataacgtaag aaaaaacaaa
     1321 gccattctgg aattattgta aattccaaaa aatagtgtta aaattgccaa agaaagcttg
     1381 atattattaa gttttctaat catttctaaa tctccttagt ggttatttgg taaatggttt
     1441 ggtagctttt agggcgtgtg gttaccccta aaagtaaatg gtgtggctcg ttcattttat
     1501 tgctttggtc agcggtaaat ggacgggctt tttttatgct ttgttctggt cgttttgtcg
     1561 ctcttcaatt agcttggtag cgacttttac aatctctttc cagcgatcac tctccaagtt
     1621 ggtctttgat tggaaagctt tttgtacagt cacgaggcta acaccttttt gtccttccct
     1681 ctcgcctttt ttaacggtta atctttcagc aatatcgctg tatgttatat catgaagcct
     1741 taataacgct ttaagttgat ctttctcgtc taggttctta aaagcgttca ataaatcttc
     1801 ctttttctcc aacttaccac ctcccttccg atttttagtt agaaatcgct ccaagggtct
     1861 tcctcttctt ctggcggctt tctcactaag tattcatttt cctttatacc aacgattttc
     1921 cgccactctt gttcccaatc ttggttatta tcatagtttt tggaaagttc ttggatacgc
     1981 ttctccagct cctctatttt ctgatctctt tcccgatctg cttcctcata tcctattcgg
     2041 attctttcca gctgttaggc ttctcgttca cgcttctttt cctgtaataa catagccagc
     2101 aaaatgagct cttccactag ttagctccct catcgctgat ttttccatct ctaagagctt
     2161 ctcgataaac atttaaaatt tgtttatcag tgaagtggga gcgatatttc acggtgtcta
     2221 catagttttc acgaaaataa gtcttgtaat cgctgataac gtaagcttgc ttggctattt
     2281 ggatttcttg cttgttgttt ttggtctcaa gttgattatt ttccttgctt aagttatagc
     2341 aatttacacc aaggataata agagcgatag ctaaaactcc aataatcacg ggataaatta
     2401 cttgcttcat tttcatttct ttcatattac tttctctcct ttaattggtt ggtttggtat
     2461 tttcaaaaga gaacggtact cattccgcca ttacgcttta accctcgtac cctttcgata
     2521 tatttatatt actaccagtg gtagtataat ttaatagatt ttttaaaata aatccataaa
     2581 taacccttgg aaattatctc aaatacacaa aaaccccata gccataacgg ttacaggttt
     2641 ttttcgatta tttaaacaac tgtttttgtc tggttctggt aaatgatcgg ctaaaattcc
     2701 taagcgatca tgttcacatt tggggcagcc actcgcaacg gattccctta aaatcgtttg
     2761 aaaagtcgat ccgcacacct tacactcgaa aaactcaagg ctctctgccg attttgggaa
     2821 gccgtctggc gcctttggag cggtcggaac gtgttggagt ttcatacctt caaggcgtga
     2881 gtacaatcta ataagatcgg ctttgcgttc ggctgggcta gtttggttag ttggtgctgt
     2941 atttggtgtt tggttagtgt tttccatgtt ggttatagct cctttatttt gcttggtttg
     3001 gtataggact agaaggctct aaaaggagcc ctcgcgcctt acaagtactt tggtttattg
     3061 gattagattg ctgacaggtg ttaccattcc acgttggaaa ggtcgatctc tggagttgga
     3121 tcgttgacag ctttttcctc tccttccata ttttccaact cttgttggta ctctactaaa
     3181 gaagctccct cgctgcttct taggcgttct tgcatatcgg ttattgttag cttatcaaac
     3241 ttcaatctta catgagtgat ctttctggag tcgctagaat tcttttccac tgttaggctt
     3301 agctctggaa agtactcttt gagagcagcg atagcaggct ttagaacgtt gtttataaaa
     3361 tctctgttat ttctcgttgg attgactcct aaaatttctc ttaaatcatt aatcctttta
     3421 taatacattc ctgtattcca aaaggtagaa agctctaaga aaaggatcat ggagtactta
     3481 ctttttaact tcacaaagtc tcttagatta aataaaatgt attggttaac cacttctgaa
     3541 aaccactcta aatattctgg attgatccgc gctgttactt ctagcgtatg cttatttatt
     3601 acccaccttg ctatagcggg cgcggttatg atctcatttt cattttcatc taccatataa
     3661 atagagtgta aatttatccc cgtttggagt aattccattt gctcgttaat tgtcagaggt
     3721 tctggctggt ttgaaaagta acgatcaact atttgtttgt tgggttctgt tgcaaagttt
     3781 taaatctact atcaaataag gtagaataat agaaaaagat agcaggagta atgacgatga
     3841 atcattttaa aggaaagcaa tttcagcagg atgtgattat tgtagccgtg ggctactatc
     3901 ttcgttataa ccttagctat cgtgaagttc aagaaatctt atatgatcgt ggcattaacg
     3961 tttctcatac gacgatttat cgttgggtgc aagaatatgg caaactactc tatcaaattt
     4021 ggaaaaagaa aaataaaaaa tccttttatt catggaaaat ggatgaaacg tacatcaaaa
     4081 ttaaaggaaa atggcattat ttgtatcgag ccatcgatgc agatggttta accttggata
     4141 tttggttacg taaaaaacgg gacacacaag cagcctatgc ttttcttaag cggttagtga
     4201 agcagtttga tgaaccgaag gttgtagtca cagataaagc cccctctatt acaagtgcct
     4261 ttaagaaact aaaagaatac ggcttttatc aagggacaga acatcgtacc attaaatacc
     4321 tgaataattt gattgaacaa gaccatcgtc cagtaaagag acgcaataaa ttctatcgaa
     4381 gtttacgcac tgcctctacc acgattaaag gcatggaagc cattcgagga ttatataaga
     4441 aaacccgaaa agaaggcact ctcttcgggt tttcggtctg tactgaaatc aaggtattat
     4501 tgggaatccc agcttaaatc atagataccg taagggattt tattctttat ttaaaacttt
     4561 gcaacagaac caactagact gtgcaaaata gagacacttg aaaaatctat cgggggtcag
     4621 aaacttaata gtttttgaca cataaacaaa atcgcgatat aatggggttg agagtgtttc
     4681 ataaacttat gtcataaagt taaggagatt tcgcatgatt ttagagaata aattgggatt
     4741 aaccaatcaa gttgagttgg ctaaggttga agaaaaactc agtaaacaaa aagcgaaaga
     4801 attgtacgat tgtggaaaaa taaatgaaat cgaagttggt acatttaaag gtttatctga
     4861 aattcatgaa tttctatttt cggatattta cgattttgcc ggaaaaatcc gatcggtcaa
     4921 tattgcaaaa ggaaattttc gatttgcacc agttatgtat ttagaacatt cgttacagca
     4981 tattgatcag atgccacaaa cttcttttga agagattatc aagaaatatg tggagatgaa
     5041 tatcgctcac ccatttcgag aaggaaatgg ccgaagtact agaatttggc tggatctcat
     5101 tttaaaggaa gaattgcaaa aagttgtaga ttggaactta atcgataaag cagactatct
     5161 ttctgcaatg gagcgaagtc ccataaacga tttggaaata cgctatctaa tttccaatgc
     5221 tctgactgat aaaattgacg atcgcgagtt atatatgaaa ggaatcgatg tcagctattt
     5281 ctatgaaggg tattctgagt atacgataga tgatttgtaa aagtaggtgg accaaatgac
     5341 gaaatatgga tatgcacgtg tctcaaccgc ttctcaaagt acaaaagaac aaattcaaca
     5401 gttgcttgag aactgcgtag agaagaagaa tattttttca gaaaaattta cgggtacaaa
     5461 acgggatcgg ccaaaattca atcagctgtt ggctggtctg aagcctggag atgaaatagt
     5521 tgttacgaag cttgatcgat ttgctcgtaa cacgagagaa gcattagaga tcattgaacc
     5581 tttactcgat gataacgtaa cgatcaaggt tttgaatcta ggaacgattg aaaatacgtc
     5641 catggggcga atggtgacac ggacgttgtt gagtgtagca gaaatggaac gtgatatgat
     5701 tgtggaacgt acccaagaag gaaaaatgtt tgcaagaaag aataatccta atttcagaga
     5761 aggacgtccg aaagcaacaa tcacaccgaa gaagaggcac gcatatgaac tgcttacttc
     5821 aggtaaatcg tataaggaag ttgaagctat aaccggtttc agtcgcagta cgctttttag
     5881 aataaagaag aaaattgaag aaagttaaaa aagaagtctc agcgaaccag acaggtaaat
     5941 acttaatgcg ttctagatat gagtctatta gcatgttgtg aaatataata tttttttatt
     6001 tacttgattt ctgctcaaaa aatgtgtatg gtaactgtaa aaggtaaagt aattaaaggt
     6061 atgctagcca cgcttactat attaggatac catcatatat ttataatgaa cgatttgttc
     6121 gtctaccaaa caacacatat cgttcagcgt aagtcacgtt taggaacgtg gcttttttag
     6181 tgttattatc gataaataat ctattgactc tattgatttt atctccatat ccctacggtg
     6241 ttgattgtct ttagatcttt catttaagaa ccaaataact atcataaaaa tcagcactgc
     6301 tgctaatata ataaacagca ttcctattgt gatattactg gatttgagtc aatatcttgg
     6361 acacatttta gtagagacgg ttaagccatt ttttcttttg ctaattcttc aaattcctgt
     6421 ggggttagat agtgaatcga gctatggatt cgatttcggt tataaaatcc ttcaatgtag
     6481 ctaaatagcg ctcgatttgc ttcttcaaaa tctgagtagc tagtcgtgta gacttcttct
     6541 tttttcaatg aggcatggaa agattcgatt ccagcattat cataaggtgt tccttttcta
     6601 ctataagaat gccttatttt gttggtttta agccattgtt ccacttctct tgctgtgtat
     6661 tggctgccca agtcagtgtg tagaatcatt ccttctggaa tgtgataatg tatttttgct
     6721 ttattcaatg tttgaatgac acaatccaca gtcattcgtt ttgaaaatgt ataactaata
     6781 attcttttcg tgtgtaaatc catgattgaa gataagtaac accaaccatt tttcttagta
     6841 ggaatgtacg taatgtcagc tgcccatttc tcacagatcg tttcagtaga aaagtcctga
     6901 tttaagagat tctcttttga aatgatggaa tggcaacagt ttttttgaca aattttataa
     6961 ggtgcagaac ttctttccgt atgctattcc gattgtcctt gacaatgagc ctcctcggat
     7021 gtgacgatct tcggcaggag ctaacagtta aagttagact gcctcgctag cgttagcaca
     7081 tccgagctca ttatcaagga ttcgctgcgc caatctcttg ttacggtaac caaccggtgt
     7141 ctcgtagcca agtgtaccgt gcaaccgaag gtggttccac caattgacat agtcaaataa
     7201 ctccaaatcc aattgttgta aggtttcaaa tgtgtattga tagacaaatt ctactttcaa
     7261 cgacttataa gttgattcag ctacggcatt atcaaaagga cagcctttat gactcaatga
     7321 tcgattgatg tcaaaagttg ttaataattc atcaatagct tggttatcaa actcttttcc
     7381 acgatcagta tgaaaaatct caacctctgt cagaggttgt ttgatacggc taaatgcttt
     7441 ttttactaga acggcatctt tatgttctcc acaagaatag ccgagaattt ctcgattgaa
     7501 cagatccaaa atgaaacaga cataattcca ttttttcccg actcgtacat aagtcaagtc
     7561 tgttacgatc gcttctaatg ggttgtctct taagaattta cgattcaata cgtttgtcgt
     7621 tttggcttca ttgcaagtag aatgatgtac tttaaaataa gcaacagtat agctcgattt
     7681 taatcctcta tttttcatga ttctactaat ttttcgtcgg ctgatctgaa tgcctcgttt
     7741 tgataaggct ttttttattt ttcttgagcc gtaggccttt cggctgcgga taaattcttc
     7801 agcgactact tcttcaagtt ctgattcgtc tttctttggt tttgattgat aataatagga
     7861 ctgacgtgat agacctaata ttctgcacat cgctgatata gggtaaagat gcttattcgc
     7921 atcgattact tgtctcttcg tccgaatatc agcgctgctt gctttaaaat atcattttcc
     7981 atttctaatt gctggtttct tttacgtagt tctaacaatt ctttttgttc aggcgtaaga
     8041 ttatcttttt ctttgaatga accactcgtt ttagattgct ttacccattt gtcaaatgct
     8101 gaagccgtta gttcatattc tcgaatgatt tctacacgtg gctttccagc taagtaaaga
     8161 ttgacgattt gttgcttgaa ttcttgtgaa aaagttcttc gtgttctctt agacataaaa
     8221 attcctcctg gtatgttttc ttctagtcta cacaccttaa tttttctgtc tagttaattg
     8281 tagcctatcc atgatcggtt tattagacct ttgaggtcta tattttttaa ctacaatcga
     8341 ccttaaattt aattgtttca ttagcttttg gacatgttta agagatactg aaatcccttc
     8401 ttttaataaa acttgatgga tctttgtggc accatagcgt tgtttattcg taaaaaaaat
     8461 tgttgaaatc ttctttttca acttattatt tctgatttct gtagctgtca acggtttatt
     8521 cttataaaaa taatagacac ttctagggat ttctaataac cgacacaaca aagaaacagt
     8581 gtaatcctta caccattttt caataaattg aacaagcgaa tttaggtttt ccgagagaat
     8641 atggctgcgg ctttttttaa gatttcaagt tcctcattta aacgagcatt ttcttttctc
     8701 agttcagcta cttcttttcc agtcagtcct gtggactgat caggtaaata taaattcttc
     8761 catttgtaaa tcgttgcttc agataagcca tattctttcg ctaaccctcg aacagaacgt
     8821 ccagtttgat tcagttcaac aatcatttgt ttaaaatttt cttcatatcg ggtcataaaa
     8881 attcatcctc tcgtagataa gtttaattta ttcttgtctc tacgaaaagc tgtctaagat
     8941 ttgatactaa caccaaatgt tgtatacccc caaacaatac acatattttg aaggattagg
     9001 attaataaag ctaaaaatat agtaagtata ctaaatatat ttactatatc tagtatactt
     9061 actatatttt aatcttttga tcgtctatta tatataatcc gttcctcgtc gtttaaagta
     9121 tcaacatagg cgtccattgc aagtttgact atttcataca taggaatatc ttttgcataa
     9181 ctaagatccc gaatggtttt tagtacggga ggatctactt gaactggttt tctttctttc
     9241 gcagtgtact ttcgttcccc taactcgaca ttaatatcat ctttaattga aatatcttca
     9301 gcaccaattt tcttcttatc tttgttcgtt ggtaataatg ccatttagtt taatctcctt
     9361 tccaagaggt aggatatgat tggccattga gtcagcatat ttaggtgtat aatcaaatcc
     9421 ttcaatatca ccatgttgtt catagtattc aattctttct tctaattctg taaagatgtc
     9481 tgcaaaaata gcccaccatc ttcgatctac ataatcattt aattggatac cattctcacc
     9541 atacatttct aaccgatccg agcctttaac aatgctttta aaaatgtttg attcaccata
     9601 cttatcaatt gttttttgat agtttgcgtg ttgagaggaa cgtcgcactg agaaaagaac
     9661 aggcaaaatt ccaatgattt gaagatgaga ctcttcaaaa ttcgtgacaa tcggaactaa
     9721 aactttatta ataaaatctt ctgttccttc cattgcgtac cgttttaatt cttgcattgc
     9781 aataatataa tctgcagcag ttaagaatgc acgaaccaca ttatctgttg atggtgggca
     9841 gtcgataaag atataatcga aattttttct caattcttct aaaggtttaa tgaaggccaa
     9901 tgatctctta cgacgatcag gatatttttc ggacaagtat tcattaagtt cttcagatcc
     9961 aggagagcca gccataatat ataaatgtgg acttacttga gtaatacctg aaacccagtc
    10021 cccttttttg attgctgcag acatggatcg atcaaagcta gtaatttgat acgttgatcc
    10081 aatgttggaa gtagtatttc tttgttggtc ataatcaatt agcaacacgt ctttttcaaa
    10141 aagttgacta gaaacaatcg ctaataaatc attgtctgta gtcttaccaa tgccgccttt
    10201 tctacctgta agcattacaa cttttcctag tttatctgat gttttaaatg cagtccgtaa
    10261 gttttccata gttccctcca atttcctata ctaaatatat ttagtatact tcatatactt
    10321 aatatattcg atatatctaa tatactccaa attgataaga attcagactt tataaggaat
    10381 atagtggata tactaaatat atttgctata ttcagtatat cagatatatt caaaatgtca
    10441 aaatatattt gtgcgttttg cgttgacaat ttagagtgaa aagaggtaaa cttaattcta
    10501 tagaaaccac agataattca ctatttacaa agtagcaaaa gcagtggtac tctttaaaca
    10561 gaaaaattac ataaaaaaaa gagacggaaa taattgattt tagcagaatc aattatttct
    10621 gaatcacatg gttaggacat gtgttcacgc tcgtctcaag aatatgtaag tagctaccaa
    10681 ctacttatat taaaagttga tcggatacct tttccgattg cctttattct accaaaaaaa
    10741 ggcgagcaac tcaacagaag aacgtttatt tagtgtactt aaattaaata ttcttaaaca
    10801 ctgaagagag aacacatact atggctgaga ttaaagctaa actgtgttct ctttttgttt
    10861 gagaaaggac gttacaatcg atgttgagcg aaatttattc agctattctt aaaaacggct
    10921 tacgtacata caaatatcga aacagcacca tgaaacctgc aggtcatatt gattccagta
    10981 ggagtggtgc tatctttgcg taccgtagca agcaattaat gaatgttggg cgtggtatgg
    11041 tcattacttc ggaagaagct attttagaga acgaaaagaa actaacgcat tggacaccta
    11101 atacctatcg ctttggtact tatgcggatg attatcgaac agtggttaaa ggtcattctg
    11161 agaaaaactt aagtcaaatc aacacatttg tagttgatat cgattcaaaa gagaaccatc
    11221 aaggcgaaat tattttagcc tgtttagatc aagtgggcta catgccaacg ctaattttag
    11281 aatcagatca tggttatcaa gtttattttg tactaaagac accaggctat gtcacaaaga
    11341 aaagcaattt caaggtgatc gatgtagcaa aaaaaatttc aaaaacaatt cgtctacagt
    11401 tggctgaaaa attgtccgga gtggatctag gatgtaacca cttcggaatt gctcgattcc
    11461 cacaagaaaa taatattgtt tttaaagaaa tgaactatca gtattctttt gctgactgga
    11521 ttcaatggtc gatgaagctt gaatcagatc aaaaaacaaa agaagatcga gaacgaaaac
    11581 taattgtctt tcctgagaaa aaagaaattc gtcaagtaga tgaaccgtgg ttcgatatgt
    11641 tacttcataa agcaaacatc gtcggcggag aaggacgtct tggtcgaaat aatgtgattt
    11701 tcacgctttc tttagcttat tactcttcag gttatgcatt ggatacttgc gaatacaata
    11761 tgttcacatt caacgaacgg ttacaggaac cgctatctga agcagaatta gtaaagattg
    11821 tacgtagtgc ttattctggt aattatcaag cagcaagcag agaattcatt attgaattgt
    11881 gccagcaatg ggtttcacca accttaaaaa ataatgatct gttcattcaa cgacgtggct
    11941 ggtggaaatt taaaaagcca cgagatcaaa gaaaatatag tcataaaaat gaatggaaag
    12001 aagatctatt ggcttatcta agcgaaaaaa gtcttgctag tgagccttat ttgaacctgt
    12061 caaaaaaaga attggcttca caactaacga tgcccaagcg aacacttgat aagatcttaa
    12121 atgagttacg agaggagaat aaagtcttct acaaggtaac acgaggaaga aatggcggaa
    12181 tgatcattgc ttcagtcaaa acgttgttcg cgagggttat tcaactaagt aaagaaaaga
    12241 gactagatta ttcaacaagg atcacagagg tatttggact caacgagagc ttagtagaag
    12301 agacatttag acaattatca acccccttga accctcttaa agaagtgaat ctttttgaag
    12361 tagatacagg ttgaaaaata aaaggtgcaa attgccttat acaatatatc tatgatactt
    12421 ctgtaggtgt tgctcccttt gcctagctac gtgtaggtgg tatacttata actgcgtatg
    12481 cagtcttatg tatcatggag gaagttgtat gtcgttaaaa aattatgtct attcacatcc
    12541 tgttaatgtg tttatcattg gtcgtttggg attatctgtg gaagtgttct gtgagcttta
    12601 tggttttaag caggggactt tgtcttcttg ggttaccagg gaaaaaacag ttgcttcttt
    12661 gccgattgag tttcttcatg ggttgtcctt agcttctggg gagactatgg atcaggtata
    12721 tgattgtttg tgtgtgttag agcaggagta tattgagtat aaaatagcta acgagttaag
    12781 aaaaaggaag aagtatatcc agtagtagtt tttatttact cttaattgtc aaattaagtt
    12841 agacaaatca tcaatactta cgtaactcaa aaatacttcc aaaggtgttc gataattcag
    12901 tgattttcta ggaatattat ttcgtttcga tgcgacagat tgaataaaag attcatctac
    12961 tgaattgaaa tccatagatt tcaataaacc atctctacgt aacaatccgt tagaattctc
    13021 gtttaggcct ctttgagacg gcgttcctgg atcagcgaaa taaatggcaa tatcattggc
    13081 attactgatc tgtttccaat ttgaaaattc ctttccacaa tcaaaagtga tggatttgaa
    13141 tagatttttc ggtacagatt caaaccaatg atttaatttg ttttcaatat caatcgcttg
    13201 tctaccacac ggtttcaatg tgatgataac ttttgataat cgctcaacta aggtaattac
    13261 agcactttta tgtttcaaac ctacgatagt gtcaccttca aggtgaccaa actcatttga
    13321 gaattggcta taatcttttt cacgttcatg aatagagcga cggaaagctt gttttccacg
    13381 tctttcttga tgtccatttg gtttacgctt gcctttcatc ggtaagtcag aaggattaaa
    13441 tagccccttt ttgaacatac gataaatggt acgagcagaa caacgaatag gaaacgctgc
    13501 acgaccaaca atcacatcgg gtgtccatcc ttgaacaacc tttctttgaa tatattctga
    13561 ttgttcctca ggtaaaacaa gcgggcgtct accacagttt gatttgtttt tcttatactg
    13621 ttgatagtac tctaaggctg attttccttg cttgaagaac aggtatactt tatggatcgt
    13681 ttgtcttgaa cgattcaaga aatgcgcagt tttcgcaaca gattgattta ttttgaaata
    13741 agactctatc attacaagtt catccgttgt aagatgggta taggtcattt gtactcactc
    13801 cttataattc tttggacgga actattttga gtgtagcaca aatgactttt ttagttgtct
    13861 agcttaattt tacaatcggc gtacttaaaa aattggttca ttgagcaacc tatcgctgct
    13921 aaagtagcaa aggaaaacgt taaaggaaag aatttaggga agaaatcgaa atgaaatcgg
    13981 acgactggat tgaacacacc tggctggttc tgttgcaaag ttttaaataa agaataaaat
    14041 cccttacggt atctatgatt taagctggga ttcccaataa taccttgatt tcagtacaga
    14101 ccgaaaaccc gaagagagtg ccttcttttc gggttttctt atataatcct cgaatggctt
    14161 ccatgccttt aatcgtggta gaggcagtgc gtaaacttcg atagaattta ttgcgtctct
    14221 ttactggacg atggtcttgt tcaatcaaat tattcaggta tttaatggta cgatgttctg
    14281 tcccttgata aaagccgtat tcttttagtt tcttaaaggc acttgtaata gagggggctt
    14341 tatctgtgac tacaaccttc ggttcatcaa actgcttcac taaccgctta agaaaagcat
    14401 aggctgcttg tgtgtcccgt tttttacgta accaaatatc caaggttaaa ccatctgcat
    14461 cgatggctcg atacaaataa tgccattttc ctttaatttt gatgtacgtt tcatccattt
    14521 tccatgaata aaaggatttt ttatttttct ttttccaaat ttgatagagt agtttgccat
    14581 attcttgcac ccaacgataa atcgtcgtat gagaaacgtt aatgccacga tcatataaga
    14641 tttcttgaac ttcacgatag ctaaggttat aacgaagata gtagcccacg gctacaataa
    14701 tcacatcctg ctgaaattgc tttcctttaa aatgattcat cgtcattcct cctgctatct
    14761 ttttctatta ttctacctta tttgatagta gatttaaaac tttgcaacag aaccaacagg
    14821 gctatagtat aagccatact taaaacagat tttacaatcc gtcacattcc aaccatataa
    14881 tccttgttcg caaccatagc gtatcccttc cataactgca ttttgaaatg attgatttaa
    14941 gtatccaaga gaaaccgagc tctcatactg cattccactt cccaacggaa gcggtgatac
    15001 agataaacca atggaagccc agaaaggatt tggcggcact tcgatgtgaa tggtatattc
    15061 tgcatttttt aacggtctct ccatataaat gactgtaggc tcttttagtt ctatctccac
    15121 atgatacttt tcttgcaaca gtgcactaat cacttccatt tgtactttcc ctaagaaaga
    15181 aagtataatt tcatgtgtcg tagaatccac ataatattgt agaagcgggt cactgtcgga
    15241 gatttctaaa agtgcatcaa gtaacatttc cctttgttga ggtttgctcg gttcaacagt
    15301 tgtttgcagc agagggagcg gattttcaat tctctctctc tgtggcaata gctttgtatc
    15361 tccaagaaca ctatttagct tcaaaaactc attttgcaaa ataacaattt ccccggaata
    15421 agccttatca attttacata attcaccagg ttctgttgca aagttttaaa tctactatca
    15481 aataaggtag aataatagaa aaagatagca ggaggaatga cgatgaatca ttttaaagga
    15541 aagcaatttc agcaggatgt gattattgta gccgtgggct actatcttcg ttataacctt
    15601 agctatcgtg aagttcaaga aatcttatat gatcgtggca ttaacgtttc tcatacgacg
    15661 atttatcgtt gggtgcaaga atatggcaaa ctactctatc aaatttggaa aaagaaaaat
    15721 aaaaaatcct tttattcatg gaaaatggat gaaacgtaca tcaaaattaa aggaaaatgg
    15781 cattatttgt atcgagccat cgatgcagat gggttaacct tggatatttg gttacgtaaa
    15841 aaacgggaca cacaagcagc ctatgctttt cttaagcggt tagtgaagca gtttgatgaa
    15901 ccgaaggttg tagtcacaga taaagccccc tctattacaa gtgcctttaa gaaactaaaa
    15961 gaatacggct tttatcaagg gacagaacat cgtaccatta aatacctgaa taatttgatt
    16021 gaacaagacc atcgtccagt aaagagacgc aataaattct atcgaagttt acgcactgcc
    16081 tctaccacga ttaaaggcat ggaagccatt cgaggattat ataagaaaac ccgaaaagaa
    16141 ggcactctct tcgggttttc ggtctgtact gaaatcaagg tattattggg aatcccagct
    16201 taaatcatag ataccgtaag ggattttatt ctttatttaa aactttgcaa cagaaccaaa
    16261 tttggaaaaa gaaaaataaa aaatcctttt attcatggaa aatggatgaa acgtacatca
    16321 aaattaaagg aaaatggcat tatttgtatc gagccatcga tgcagatggt ttaaccttgg
    16381 atatttggtt acgtaaaaaa cgggacacac aagcagccta tgcttttctt aagcggttag
    16441 tgaagcagtt tgatgaaccg aaggttgtag tcacagataa agccccctct attacaagtg
    16501 cctttaagaa actaaaagaa tacggctttt atcaagggac agaacatcgt accattaaat
    16561 acctgaataa tttgattgaa caagaccatc gtccagtaaa gagacgcaat aaattctatc
    16621 gaagtttacg cactgcctct accacgatta aaggcatgga agccattcga ggattatata
    16681 agaaaacccg aaaagaaggc actctcttcg ggttttcggt ctgtactgaa atcaaggtat
    16741 tattgggaat cccagcttaa atcatagata ccgtaaggga ttttattctt tatttaaaac
    16801 tttgcaacag aacctatgat cggttttgtt ccttatttag ttgatacgga cagcgcaacg
    16861 ataaaatcaa acctggaaga actgtataag caacataaag aagataactt ggttttccaa
    16921 aatattatca agcgaagtaa taaagtaagt acctggtcta aaaacggcat tacagagcat
    16981 aaaggctatg acaaaaaagt tttatccatg tataagaacg tattttttga aatgcttgag
    17041 cgaattattc aattagaaaa cgaaaaagaa tagaatcaca aatcacaagt gattaatcac
    17101 aaatcacttg tgatttgtga ttgttgatga taaaataaga gtaagaagaa atagaaagaa
    17161 gtgagtgatt gtgggaaatt taggcgcaca aaaagcaaaa cgaaatgata caccaatcag
    17221 tgcaaaaaaa gatataatgg gagataagac ggttcgtgtt cgtgctgact tgcaccatat
    17281 cataaaaatc gaaacagcaa agaatggcgg aaacgtaaaa gaagttatgg atcaagcctt
    17341 agaagaatat atacggaaat atttacctga caaactttaa aaggagtgaa aatgaaatgg
    17401 cagttacgta tgaaaaaaca tttgaaatag agatcattaa cgaattatcg gcaagcgttt
    17461 ataatcgagt attaaactat gttttgaacc atgaattaaa taaaaatgac tctcaattat
    17521 tggaagtcaa tttattaaac caattaaagc ttgcaaaacg tgtaaatctt tttgattatt
    17581 ctttagaaga attacaagcc gttcatgagt attggcggtc aatgaatcgt tactcaaaac
    17641 aagttttgaa taaagagaaa gtggcttaat atggcaaata tagtcaattt tactgacaaa
    17701 caatttgaga atcgcttaaa tgataattta gaagaattga ttcaaggaaa aaaagcggtt
    17761 gaatcgccaa ccgctttttt acttggtggg caaccagggt cagggaaaac cagtttgcga
    17821 tcagcaattt ttgaagaaac acaagggaat gttattgtca ttgataatga tacctttaaa
    17881 caacagcacc ctaattttga tgaactagtg aaactttatg aaaaagacgt agtaaaacac
    17941 gttacccctt attctaatcg catgacagaa gcgatcataa gccgtttgag cgatcaaggg
    18001 tataatttgg tgatcgaagg tacaggacga acaacagacg ttcctattca aaccgcaaca
    18061 atgcttcaag ccaaaggtta tgaaacaaaa atgtatgtca tggcagtacc taaaatcaac
    18121 tcatatttag gaacaattga acgatatgaa accatgtatg cagatgatcc aatgacagcc
    18181 agggcaacac caaaacaagc gcatgatatt gttgtcaaaa acttaccgac caatttagaa
    18241 acccttcata aaacgggctt atttagcgat ataaggctat ataacagaga aggagtaaaa
    18301 ctctattcaa gtttggaaac accttctatt agtccaaaag aaaccttaga aaaagaattg
    18361 aatcgtaaag tatcagggaa agaaattcaa ccgactttag aacgaataga gcaaaaaatg
    18421 gttctaaata aacaccaaga gacacctgaa tttaaagcaa ttcaacaaaa attggaaagc
    18481 ttgcagccac ctacaccacc aatacccaaa acacctaaac ttccaggtat ttaaacctta
    18541 aaaaaggaaa agagtagtta ccaaaaaacg gtaactactc tttttttata aaaacatttc
    18601 ctcatgttgg ggtcccgagc gcctacgagg aatttgtatc gataagaaat agatttaaaa
    18661 atttcgctgt ttttttctaa tttcattttg aggtgaatta attggtagtt attagaggtg
    18721 ccctatacct aataatttat ctacattccc tttagtaacg tgtaactttc caaatttaca
    18781 aaagcgactc atagaattat ttcctcccgt taaataatag ataactatta aaaatagaca
    18841 atacttgctc ataagtaacg gtacttaaat tgtttacttt ggcgtgtttc attgcttgat
    18901 gaaactgatt tttagtaaac agttgacgat attctcgatt gacccatttt gaaacaaagt
    18961 acgtatatag cttccaatat ttatctggaa catctgtggt atggcgggta agttttatta
    19021 agacactgtt tacttttggt ttaggatgaa agcattccgc tggcagctta agcaattgct
    19081 gaatcgagac ttgagtgtgc aagagcaacc ctagtgttcg gtgaatatcc aaggtacgct
    19141 tgtagaatcc ttcttcaaca atcagataga tgtcagacgc acggctttca aaaaccactt
    19201 ttttaataat ttgtgtgctt aaatggtaag gaatattccc aacaatttta tacctctgtt
    19261 tgttagggaa ttgaaactgt agaatatctt ggtgaattaa agtgacacga gtattcagtt
    19321 ttaatttttc tgacgataag ttgaatagat gactgtctaa ttcaatagac gttacctgtt
    19381 tacttatttt agccagtttc gtcgttaaat gccctttacc tgttccaatt tcgtaaacgg
    19441 tatcggtttc ttttaaattc aattgtttta ttatttggtt gagtactttt tcactcgtta
    19501 aaaagttttg agaatatttt atatttttgt tcatgttatc actcctgaag tgattacatc
    19561 tataaacaaa tacagaagtt aaacgatttg tttgtaattt tagttatctg tttaaaaagt
    19621 cataagatta gtcactggta ggaattaatc taacgtattt atttatctgc gtaatcactg
    19681 tttttagtct gtttcaaaac agtagatgtt ttatctacat aacgcatttg gaataccaac
    19741 atgacgaatc cctccttctt aattacaaat ttttagcatc taatttaact tcaattccta
    19801 ttatacaaaa ttttaagata atgcactatc aacacactct taagtttgct tctaagtctt
    19861 atttccataa ctttagggtt aaccatacgc aagaccaatc actctcggac aatactcatg
    19921 attttaatga taaaatccat gttaaaccca tagataagaa atacacctgc aataaccgtt
    19981 acctgtttgt gccaatttaa aaatgcacca cttttttata atttcgtttg tcaaattaag
    20041 ttagacaaat catcttttgt gacgtaactc aaaaatactt ccattggtgt ccgatagtgt
    20101 aatgattttc taggaatatg atttcgtttc gatgccaccg attggataaa ggtttcagat
    20161 acaccattaa aatccatagc tttatacaaa ccatctttac gtaataagcc atttgaatgt
    20221 tcattcaatc ctcgttgaga aggtgttcct ggatccgcaa aataaattga aatatcgttg
    20281 gtattactaa tctttttcca atttgagaat tcttttccac aatcaaatgt gatggattta
    20341 aataagtttt ttgggacaca acgaaaccat tgattcagcc tattttcaat gtctttagcc
    20401 tgtctgcctt cgggtttcaa ggtaatgatg actttagata gccgttcaac taatgtgatg
    20461 accgcgcttt tatgttttcc acccacgata gtgtcacctt ccaggtgacc aaattcatga
    20521 tcaaactggg tatagtctgt ctttctgtct cggattgacc ggcgaaaccc ttgttttcct
    20581 cttttttctt tatgaccgtt tggttttctt tttcccttca ttggtaaatc gtgagtgtca
    20641 aaggttttat ctttaaacat tcgatacagt gtgcgtaccg aacaagcaat aggaaactct
    20701 gctcgaccaa taaggacatc aggagcccac ccttgaacaa cctttttttg aatgtattcc
    20761 tgttgctcat caggtaaaac aatcggatgt cttccgcagt tacgtttgtt tttcttatat
    20821 tgtttatagt agctcattgc gcttccacca gatttaagaa aacgatagac cttataaata
    20881 gtttgtcgag aacgttgtaa cagattggct acttttgaaa caggttgtga ttgattgaaa
    20941 taagcttcta tcattacgag ttcagttggt gtaagatggt tataggtcat ttgtactcac
    21001 tccttataat tctttcgtcg gaactatttt gagtgtagca caaatgactt tttttagttg
    21061 tctagcttaa ttttacaatc ggcgtaatta aaacggttga aaactgtacc actaataact
    21121 cacaatagag agatgtcacc gtcaagttaa atgtacaaaa taacagcgaa atttttaaat
    21181 ctatttctta tcgatacaaa ttcctcgtag gcgctcggga cccctatcta gcgaactttt
    21241 agaaaagata taaaacatca gagtatggac agttgcggat gtacttcaga aaagattaga
    21301 tgtctaaaaa gcttgtagtt aaagcttttt agacatctaa atctaggtac taaaacaatt
    21361 catccagtaa aatataatat tttattttct cccaatcagg cttgatcccc agtaagtcaa
    21421 aaaatagctc gacatactgt tcttccccga tatcctccct gatcgaccgg acgcagaagg
    21481 caatgtcata ccacttgtcc gccctgccgc ttctcccaag atcaataaag ccacttactt
    21541 tgccatcttt cacaaagatg ttgctgtctc ccaggtcgcc gtgggaaaag acaagttcct
    21601 cttcgggctt ttccgtcttt aaaaaatcat acagctcgcg cggatcttta aatggagtgt
    21661 cttcttccca gttttcgcaa tccacatcgg ccagatcgtt attcagtaag taatccaatt
    21721 cggctaagcg gctgtctaag ctattcgtat agggacaatc cgatatgtcg atggagtgaa
    21781 agagcctgat gcactccgca tacagctcga taatcttttc agggctttgt tcatcttcat
    21841 actcttccga gcaaaggacg ccatcggcct cactcatgag cagattgctc cagccatcat
    21901 gccgttcaaa gtgcaggacc tttggaacag gcagctttcc ttccagccat agcatcatgt
    21961 ccttttcccg ttccacatca taggtggtcc ctttataccg gctgtccgtc atttttaaat
    22021 ataggttttc attttctccc accagcttat ataccttagc aggagacatt ccttccgtat
    22081 cttttacgca gcggtatttt tcgatcagtt ttttcaattc cggtgatatt ctcattttag
    22141 ccatttatta tttccttcct cttttctaca gtatttaaag ataccccaag aagctaatta
    22201 taacaagacg aactccaatt cactgttcct tgcattctaa aaccttaaat accagaaaac
    22261 agctttttca aagttgtttt caaagttggc gtataacata gtatcgacgg agccgatttt
    22321 gaaaccacaa ttatgataga atttacaagc tataaggtta ttgtcctggg tttcaagcat
    22381 tagtccatgc aagtttttat gctttgccca ttctatagat atattgataa gcgcgctgcc
    22441 tatgccttgc cccctgaaat ccttacatac ggcgatatct tctatataaa agataacccg
    22501 tggtgctagt taattttttc ctagaggaaa atgtctaaac atgttggtaa atcaacaaaa
    22561 aaacgcatat agtagtctca aaactcccaa gaaatgggct ctataattta tgggactgat
    22621 gaatcagaat tgattcttca gccccatttt cattttaggt attaaaaaac atatcgttct
    22681 ctagtatgat taaatcacca caaaataaac aactgagagg acgatacgct atatgaatga
    22741 ttctatcaaa aaaatgctga gaataacaga gaaagatttg atgattacag aggtctctta
    22801 cgagaccctt cagaagaaaa agacgttggt cgtcgatgct gttctctcgc ctactcctcg
    22861 tgcttgtaga agttgtggtt ctactgtggt agatggaaac gggaaagcaa ttatagtgaa
    22921 aaatggaaaa aaggaaacga ttgtccgttt tgaacaatac aatcatatgc ctttggttat
    22981 gcgcctaaaa aagcaacgct atacctgtaa aaactgtcgc acccattgga cggctcaaag
    23041 ttattttgtc caacccagac attcaatcgc aaatcatgtt agatataaaa ttgcttcttt
    23101 actgactgaa aaagtatctt tatcttttat tgcgaaaagc tgtcaggtat ctttgaccac
    23161 cgttattcgt acattgaaag agtttaaaag ctatttacca aagcaatcta agaagatcct
    23221 ccccagagta ttgatggttg acgaatttcg ttcgcatgct tccatagaag ataagatgag
    23281 ctttatttgc gcggatggcg aaacaggaaa attaatagat gttttgccta cgcgtaaatt
    23341 acctcgatta acaagctatt tcttaggttg taccaatcca gaagaagtag aattcttggt
    23401 gacagacatg aacgccgcct acttccagct caccaaacgt gttctgccaa atgcgaaagt
    23461 cgtgattgat cggtttcata ttgtcaaaca catgaatcaa gcgttcaatg agttgcgtat
    23521 ccgtgaaatg aatgaacttc gtaaagccgg acagaaaagc caggcagaaa aactgaaaaa
    23581 gaactggcgc tttttgctaa aaaatcgtgc aaacatcaac cattatgaat acaaaacatg
    23641 gaaaagtttc cgagcaccaa aatacccatt tcttactgaa gcaatgatga ttgatcgatt
    23701 gcttgagttt tctccgcccc taaaggaggc gtatcccttt tttcatgaat tagttgaagc
    23761 ctttcgagac aaagaccctg acttattttt ctccttattg gcagaacttc ccgaaacgtt
    23821 agatgacagc tttcgggaaa agcttcaaaa ccttctgacc tatgaagaag gcatcaccaa
    23881 cgcaatgatc tatccttatt ccaatggaaa aatagaagcg aagaataccc acataaagac
    23941 aatgaaacga gtatcctacg gatttaaatc atttgagaac atgagaatta gaatcttttt
    24001 gatcaatcaa ttaatcaatg taagataaca aaaaatctga gccagaatgt ggttcattct
    24061 gactcagatt tgattttgca caactcatca gtccttattg acaaagagcc ataatacctt
    24121 gatttcagta cagaccgaaa acccgaagag agtgccttct tt
//
