LOCUS       NZ_CP054578            28716 bp    DNA     circular CON 12-SEP-2023
DEFINITION  Staphylococcus saprophyticus strain UTI-050 plasmid pUTI-050-3,
            complete sequence.
ACCESSION   NZ_CP054578
VERSION     NZ_CP054578.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN15089828
            Assembly: GCF_013343055.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus saprophyticus
  ORGANISM  Staphylococcus saprophyticus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 28716)
  AUTHORS   Stephens,C., Wright,M., Hartman,A., Gonzales,A., Sensabaugh,G.,
            Robinson,P., Lopez,G. and Hess,D.
  TITLE     Complete genome sequences of diverse uropathogenic Staphylococcus
            saprophyticus isolates from a college health center
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 28716)
  AUTHORS   Stephens,C., Wright,M., Hartman,A., Gonzales,A., Sensabaugh,G.,
            Robinson,P., Lopez,G. and Hess,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JUN-2020) Biology, Santa Clara University, 500 El
            Camino Real, Santa Clara, CA 95054, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 168x
            Sequencing Technology :: Illumina MiSeq, Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 09/12/2023 03:38:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,706
            CDSs (total)                      :: 2,621
            Genes (coding)                    :: 2,541
            CDSs (with protein)               :: 2,541
            Genes (RNA)                       :: 85
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 62
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 80
            CDSs (without protein)            :: 80
            Pseudo Genes (ambiguous residues) :: 0 of 80
            Pseudo Genes (frameshifted)       :: 42 of 80
            Pseudo Genes (incomplete)         :: 33 of 80
            Pseudo Genes (internal stop)      :: 23 of 80
            Pseudo Genes (multiple problems)  :: 16 of 80
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP054578.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..28716
                     /organism="Staphylococcus saprophyticus"
                     /mol_type="genomic DNA"
                     /strain="UTI-050"
                     /isolation_source="urine specimens"
                     /host="Homo sapiens"
                     /db_xref="taxon:29385"
                     /plasmid="pUTI-050-3"
                     /geo_loc_name="USA: California"
                     /collection_date="2019"
     gene            1..972
                     /locus_tag="HSZ50_RS13295"
                     /old_locus_tag="HSZ50_13315"
     CDS             1..972
                     /locus_tag="HSZ50_RS13295"
                     /old_locus_tag="HSZ50_13315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017175392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_040030454.1"
                     /translation="MPRKNIKNQANQNFYMLHKVLFINEKYKKLSDSAKVTYAILNDRV
                     SLSIKNNWIDQNGDIYFIFTNENLQEVLDKSKNTITKIKKELQEVGLLEQVKTGFNRPN
                     KLYLHEIETNITIEKEIQNSTSNDDESSDIKDSQILGLQNPKQWDSRIPNDGTPESQNL
                     DPNDTEFSNTDYIETENNDTNDLNDTPNNISENAHSNHTNHQQTEFNNDALKFQVLEEL
                     PQQIKDYLSNFEIREIHIIKSVLLKGKKSFNNAHDTYYRLEDVEFEIVSVLKRFKAMLL
                     QKNETVEAMQGYLMQSIKAELEEIHALNMRRQNMKQHNIFNQ"
                     /name="replication initiator protein A"
     gene            <989..1291
                     /locus_tag="HSZ50_RS13300"
                     /old_locus_tag="HSZ50_13320"
                     /pseudo=""
     CDS             <989..1291
                     /locus_tag="HSZ50_RS13300"
                     /old_locus_tag="HSZ50_13320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001568503.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            1899..2042
                     /locus_tag="HSZ50_RS13305"
                     /old_locus_tag="HSZ50_13325"
     CDS             1899..2042
                     /locus_tag="HSZ50_RS13305"
                     /old_locus_tag="HSZ50_13325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002324169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002324169.1"
                     /translation="MKKTERNLFSIFLSLGSLFAIFSGFFILGIGMLIGGATLLTKSIS
                     EE"
                     /name="hypothetical protein"
     gene            3595..4014
                     /locus_tag="HSZ50_RS13315"
                     /old_locus_tag="HSZ50_13335"
     CDS             3595..4014
                     /locus_tag="HSZ50_RS13315"
                     /old_locus_tag="HSZ50_13335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002512549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_040029815.1"
                     /translation="MTNKSHRKAKTININLTEEEYKKVKALAEDRDLNPTAYTRLAALG
                     NRIKPTVVYNTDEYTEQLKKEKQTLEMALETSVPKEDVELLEAQCESYKTYIDTFKKFL
                     QYVQEDAEYINLNGYKRDEQLKAEMKDAIKSFFEN"
                     /name="hypothetical protein"
     gene            complement(4185..4628)
                     /gene="tnpA"
                     /locus_tag="HSZ50_RS13320"
                     /old_locus_tag="HSZ50_13340"
     CDS             complement(4185..4628)
                     /gene="tnpA"
                     /locus_tag="HSZ50_RS13320"
                     /old_locus_tag="HSZ50_13340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017636311.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
                     /protein_id="WP_169926875.1"
                     /translation="MYLGGIHMLVKTRTNVYDFNFHLVWVTKYRASIFDDESKRKVMKQ
                     ILQSIAENHEIIINEIEVLPDHIHMMISFNPKHAPSSIVKTLKGRSARAWFKQYPETKE
                     KLWQGHLWSPSFFMATLGNMSKDVVQTYIQNQLTKYNAGRPRQ"
                     /name="tnpA"
     gene            4708..5850
                     /locus_tag="HSZ50_RS13325"
                     /old_locus_tag="HSZ50_13345"
     CDS             4708..5850
                     /locus_tag="HSZ50_RS13325"
                     /old_locus_tag="HSZ50_13345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014125095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-guided endonuclease TnpB family protein"
                     /protein_id="WP_040029817.1"
                     /translation="MYKGVECKLYPNEKQANTIQMTLGHTRFVWNQMLSMLNERYRNNK
                     DLKMLSYSTLSSLIPQLKREYAWLNDVDSVAIQCAVKTLSETFDRFFKGYCRYPKFKSR
                     KNNRQSYLSTIRGNNIRFNHNQRYIKLPKLAWVKCKSSLKHIENERIKSVTIKQNATGQ
                     YYMSVLVTSENQALPKTGKYLGIDLGVSDLAITSDGQKYRSQKLHLKYQKQLHFWEKRL
                     ARRRLKAKAEGIALVDTKNYQKARQHVARIHEKIANTRKDYLHKITTELVENYDVIVIE
                     DLKTNNMIKNHKLARSIASQSWRQFRVFLEYKCAMYDKQCVVVNPYKTSQKCSHCGFDS
                     GKKDLDIRKWSCPKCNVEHDRDINAAKNIMHIGLEQALVK"
                     /name="RNA-guided endonuclease TnpB family protein"
     gene            complement(7617..7883)
                     /locus_tag="HSZ50_RS13330"
                     /old_locus_tag="HSZ50_13350"
     CDS             complement(7617..7883)
                     /locus_tag="HSZ50_RS13330"
                     /old_locus_tag="HSZ50_13350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501215.1"
                     /GO_process="GO:0008219 - cell death [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Txe/YoeB family addiction module toxin"
                     /protein_id="WP_069822312.1"
                     /translation="MDNYSISIKNSAKSDLKKIKQSQLKTQFLKIVDTLKEDPYFPSQS
                     FEKLQPKHLERYSRRINHQHRVVYTVDEDDKEVFILSAWSHYE"
                     /name="Txe/YoeB family addiction module toxin"
     gene            complement(7884..8141)
                     /locus_tag="HSZ50_RS13335"
                     /old_locus_tag="HSZ50_13355"
     CDS             complement(7884..8141)
                     /locus_tag="HSZ50_RS13335"
                     /old_locus_tag="HSZ50_13355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000587616.1"
                     /GO_component="GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
                     /protein_id="WP_069822313.1"
                     /translation="MNIKTPTNARKEFYELLKQVNDSHEPVIISSSKSENNAVIISQKD
                     WDSIQETLYLETTGTMDKVREREKDNSGYTNIDDIDWDNL"
                     /name="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
     gene            8348..8449
                     /locus_tag="HSZ50_RS13340"
                     /old_locus_tag="HSZ50_13360"
     CDS             8348..8449
                     /locus_tag="HSZ50_RS13340"
                     /old_locus_tag="HSZ50_13360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_002446825.1"
                     /translation="MIEALVHITTTVISGCIVALFTHWLRTRNNKKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(8731..10191)
                     /gene="zwf"
                     /locus_tag="HSZ50_RS13345"
                     /old_locus_tag="HSZ50_13365"
     CDS             complement(8731..10191)
                     /gene="zwf"
                     /locus_tag="HSZ50_RS13345"
                     /old_locus_tag="HSZ50_13365"
                     /EC_number="1.1.1.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360133.1"
                     /GO_function="GO:0004345 - glucose-6-phosphate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate dehydrogenase"
                     /protein_id="WP_069825656.1"
                     /translation="MDKNLSSLITIFGGTGDLSYRKLLPSIFNLYKKGHFKKLVIISTG
                     LEDISDEEYRSKVKQILLSRENFEMVNLFLDNIFYFQQNVEDKTSWNKLKELSNDIDKK
                     YCLDGNRLFYLAMNPQFFKIITQSISQSGLSDTNGFSRLIIEKPFGKDLKSAEDLNKHI
                     RQYFKEEEIFRIDHYLGKEMVQNIESLRFGNTIFEPLWNNKYISNVQITLSETLGIEDR
                     GQYYDSTGALKDMVQNHALQILTLIAMEKPESRNSKDIRLKKIELLNNIKFLKGADVHK
                     YFVRGQYINGIINETPIMSYHEEKGVDSDSTTETFVAGKVLINNRRWEGTPFYIRTGKR
                     LGKKATEIVIEFKKNNNTLRYENNNEDTDCNLLVINIEPNAKISLYIYENKSNRNNRSH
                     NMKIYNSIDKNQVVDAYESLICDALIGNQTNFVHWEELKHSWEFIDYISTEWKKSNVTI
                     PQYKPGSFGPKESDQLLKQDNFEWWNNL"
                     /name="zwf"
     gene            complement(10255..11661)
                     /gene="gndA"
                     /locus_tag="HSZ50_RS13350"
                     /old_locus_tag="HSZ50_13370"
     CDS             complement(10255..11661)
                     /gene="gndA"
                     /locus_tag="HSZ50_RS13350"
                     /old_locus_tag="HSZ50_13370"
                     /EC_number="1.1.1.44"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500120.1"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA];
                     GO:0004616 - phosphogluconate dehydrogenase
                     (decarboxylating) activity [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent phosphogluconate dehydrogenase"
                     /protein_id="WP_069825657.1"
                     /translation="MSSNIGILGLGVMGKNLAWNIEDKKYSVSIHSRDNNEINDTIQKS
                     HYQKIYPAYNLKEFVDSLEKPRKILLMIKAGSPTDNMINTLLPLLDDDDILIDGGNTNY
                     QDTIRRNKALAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDAISAKAQ
                     DGASCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKDLLGMSHTEISQTFKDWN
                     AGELESYLIEITGDIFTELDENNEPLVEKILDTAGQKGTGKWTSINALELGIPLTIITE
                     SVFARFISSIKEERVNASKSLNGPQASFDGNKEEFLEKIRKALYMSKICSYAQGFAQMR
                     KSSEDHEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPELENLLLDPYFKNIVTDY
                     QEALRDVVATGVKNGVPTPGFSASVNYYDSYRSEDLPANLIQAQRDYFGAHTYERKDHE
                     GVFHTQWDEE"
                     /name="gndA"
     gene            complement(11693..13024)
                     /locus_tag="HSZ50_RS13355"
                     /old_locus_tag="HSZ50_13375"
     CDS             complement(11693..13024)
                     /locus_tag="HSZ50_RS13355"
                     /old_locus_tag="HSZ50_13375"
                     /EC_number="5.3.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_499453.1"
                     /GO_function="GO:0004347 - glucose-6-phosphate isomerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="WP_069825658.1"
                     /translation="MTHIQLDYGKTLEFFGEHELEQQKDIVKTLHKTIHGGTGAGNDFL
                     GWVDLPVDYDKEEFSRIVEASKRIKANSDVLVVIGIGGSYLGARAAIEMLTSSFRTNND
                     YPEIVFVGNHLSSSYTKELVDYLADKDFSVNVISKSGTTTEPAVAFRLFKQLVENKYGK
                     EEAKKRIFATTDKQKGALKQLATNEGYETFVVPDDVGGRYSVLTAVGLLPIAAAGINIE
                     AMMIGAAKARKELSSDKLEENIAYQYATIRNLLYSKGYTTEMLINYEPSMQYFNEWWKQ
                     LFGESEGKDFKGIYPSSANYTTDLHSLGQYVQEGRRFLFETVVKVNHPKHDLTIEEDSD
                     DLDGLNYLAGKTIDEVNTKAFEGTLLAHTDGGVPNIVVNIPQLDEETFGYVVYFFELVC
                     AMSGYQLGVNPFNQPGVEAYKQNMFALLGKPGFEDMKKDLEARL"
                     /name="glucose-6-phosphate isomerase"
     gene            13225..13857
                     /gene="hxlA"
                     /locus_tag="HSZ50_RS13360"
                     /old_locus_tag="HSZ50_13380"
     CDS             13225..13857
                     /gene="hxlA"
                     /locus_tag="HSZ50_RS13360"
                     /old_locus_tag="HSZ50_13380"
                     /EC_number="4.1.2.43"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019834869.1"
                     /GO_function="GO:0043801 - hexulose-6-phosphate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019647 - formaldehyde assimilation via
                     ribulose monophosphate cycle [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hexulose-6-phosphate synthase"
                     /protein_id="WP_000422872.1"
                     /translation="MELQLAIDLLNKEEAAELAKKVEEYVDIVEIGTPIVINEGLPAVQ
                     HLNENISNAKVLADLKIMDAADYEVSQAVKFGADVVTILGVAEDASIKAAVEEAHKNNK
                     QLLVDMIAVQDLEKRAKELDEMGADYIAVHTGYDLQAEGQSPLDSLRKVKSVIKNSKVA
                     VAGGIKPDTIKEIVAEEPDLVIVGGGIANADDPVEAAKQCRDAIEGK"
                     /name="hxlA"
     gene            13860..14408
                     /gene="hxlB"
                     /locus_tag="HSZ50_RS13365"
                     /old_locus_tag="HSZ50_13385"
     CDS             13860..14408
                     /gene="hxlB"
                     /locus_tag="HSZ50_RS13365"
                     /old_locus_tag="HSZ50_13385"
                     /EC_number="5.3.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002505085.1"
                     /GO_function="GO:0043800 - hexulose-6-phosphate isomerase
                     activity [Evidence IEA]"
                     /GO_process="GO:1901135 - carbohydrate derivative metabolic
                     process [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-3-hexuloisomerase"
                     /protein_id="WP_001826328.1"
                     /translation="MTTFNHYQLILDELKGTLSHVKDEEFDGFVSEVTEASRIFIAGKG
                     RSGFVANSFAMRLNQLGKQAFVIGESTTPSIQKDDLFIVISGSGSTEHLRLLAEKAKSV
                     DAKVVLLTTKLDSAIGEIADTVVELPAGTKHDATGSDQPLGSLFEQSSQIFLDSVVIGL
                     MTQLDVEETTMQNNHANLE"
                     /name="hxlB"
     gene            14497..14829
                     /locus_tag="HSZ50_RS13370"
                     /old_locus_tag="HSZ50_13390"
     CDS             14497..14829
                     /locus_tag="HSZ50_RS13370"
                     /old_locus_tag="HSZ50_13390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000291486.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_002505086.1"
                     /translation="MYYKGKEFFTSKDLALCVIGGKWKIPIIFHLLQDKVLRLSELQKK
                     LPHVNQRMLIRQLRELEEDQIIERHIYSVVPPKVEYKLTSIGYKLDKVVYAICEWGDLF
                     KDEIIH"
                     /name="helix-turn-helix domain-containing protein"
     gene            complement(14994..15667)
                     /locus_tag="HSZ50_RS13375"
                     /old_locus_tag="HSZ50_13395"
     CDS             complement(join(14994..15061,15061..15667))
                     /locus_tag="HSZ50_RS13375"
                     /old_locus_tag="HSZ50_13395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001015311.1"
                     /ribosomal_slippage=""
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WP_223200496.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPVLYQIWKKKHKKAYYKWRVDETYIKIKGQWCYLYRAIDADGHTLDIWL
                     RKKRDHQSAYAFIKRLIKQFGKPQMIITDQAPSTKVAMAKIIKVFKLKPNCHCTSKYLN
                     NFIEQDHRHIKVRKTRYQSVNTAKNTLKGIECIYGLYKKNRRSLQIYGFSPCHEISYML
                     AG"
                     /name="IS6 family transposase"
     gene            15832..15927
                     /locus_tag="HSZ50_RS13380"
                     /old_locus_tag="HSZ50_13400"
     CDS             15832..15927
                     /locus_tag="HSZ50_RS13380"
                     /old_locus_tag="HSZ50_13400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_000889978.1"
                     /translation="MLEILVHITTTVISGCIIALFTHWLRNRNNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(16077..16307)
                     /locus_tag="HSZ50_RS13385"
                     /old_locus_tag="HSZ50_13405"
     CDS             complement(16077..16307)
                     /locus_tag="HSZ50_RS13385"
                     /old_locus_tag="HSZ50_13405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002471858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002471858.1"
                     /translation="MDSIENACLISQITFKVNSPYKNMSEDYMDIKESDRIIMKAILNK
                     CGIDLQKSNHKLNNVMPSYNVFIRKDELDYR"
                     /name="hypothetical protein"
     gene            16674..17282
                     /locus_tag="HSZ50_RS13390"
                     /old_locus_tag="HSZ50_13410"
     CDS             16674..17282
                     /locus_tag="HSZ50_RS13390"
                     /old_locus_tag="HSZ50_13410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_046467871.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTLGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKDVQLMITSLPMINEVIGNPL
                     LDKFMKDLIVQILAMVSEQERNESKRRQAQGIQVAKYKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGKAISKIAKEVNITRQTVYRIKHDKGLS"
                     /name="recombinase family protein"
     gene            complement(<17942..>18057)
                     /locus_tag="HSZ50_RS13395"
                     /old_locus_tag="HSZ50_13415"
                     /pseudo=""
     CDS             complement(<17942..>18057)
                     /locus_tag="HSZ50_RS13395"
                     /old_locus_tag="HSZ50_13415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002484560.1"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /name="DUF536 domain-containing protein"
     gene            complement(18496..19044)
                     /gene="hxlB"
                     /locus_tag="HSZ50_RS13400"
                     /old_locus_tag="HSZ50_13420"
     CDS             complement(18496..19044)
                     /gene="hxlB"
                     /locus_tag="HSZ50_RS13400"
                     /old_locus_tag="HSZ50_13420"
                     /EC_number="5.3.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011303355.1"
                     /GO_function="GO:0043800 - hexulose-6-phosphate isomerase
                     activity [Evidence IEA]"
                     /GO_process="GO:1901135 - carbohydrate derivative metabolic
                     process [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-3-hexuloisomerase"
                     /protein_id="WP_037551413.1"
                     /translation="MTEITNYRLILDEIDNTLSHVKDSEAETFLKQIIKAEQVFVSGKG
                     RSGFVANSFAMRLNQLGKGAHVVGESTTPSITEKDLFVILSGSGSTEHLRLLADKAKAV
                     GAEVVLLSTNPTSNIGELANAVIELPAGTKYDAEGSAQPLGSLFEQASQVFLDSIVLDL
                     MTEINVDEETMQQNHANLE"
                     /name="hxlB"
     gene            complement(19047..19679)
                     /gene="hxlA"
                     /locus_tag="HSZ50_RS13405"
                     /old_locus_tag="HSZ50_13425"
     CDS             complement(19047..19679)
                     /gene="hxlA"
                     /locus_tag="HSZ50_RS13405"
                     /old_locus_tag="HSZ50_13425"
                     /EC_number="4.1.2.43"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019834869.1"
                     /GO_function="GO:0043801 - hexulose-6-phosphate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019647 - formaldehyde assimilation via
                     ribulose monophosphate cycle [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hexulose-6-phosphate synthase"
                     /protein_id="WP_046467870.1"
                     /translation="MELQLAIDLLNKEDAAELANKVKDYVDIVEIGTPIVINEGLPAVQ
                     HLNDNIDSVKVLADLKIMDAADYEVSQAVKFGADIVTILGVAEDASIKAAVDEAHKHGK
                     QLLVDMIAVQDLEKRAKDLDDLGADYIAVHTGYDLQAEGQSPLESLRKVKSVISNSKVA
                     VAGGIKPDTIKDIVAENPDLIIVGGGIANADDPVEAAKQCRAAIEGK"
                     /name="hxlA"
     gene            19770..20114
                     /locus_tag="HSZ50_RS13410"
                     /old_locus_tag="HSZ50_13430"
     CDS             19770..20114
                     /locus_tag="HSZ50_RS13410"
                     /old_locus_tag="HSZ50_13430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002508649.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_002508649.1"
                     /translation="MLIEYNNKLFYTSKDLALSVIGGRWKIPIIYHLLQSEVLRLSELE
                     KKLPDINQRMLIRQLRELEKDMIIKRTIYPVVPPKVEYRLTSVGLSLDNVVYGICEWGD
                     EYLKLINNEN"
                     /name="helix-turn-helix domain-containing protein"
     gene            <20452..20574
                     /locus_tag="HSZ50_RS13415"
                     /old_locus_tag="HSZ50_13435"
                     /pseudo=""
     CDS             <20452..20574
                     /locus_tag="HSZ50_RS13415"
                     /old_locus_tag="HSZ50_13435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011303358.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /name="EamA family transporter"
     gene            21146..22294
                     /locus_tag="HSZ50_RS13420"
                     /old_locus_tag="HSZ50_13440"
     CDS             21146..22294
                     /locus_tag="HSZ50_RS13420"
                     /old_locus_tag="HSZ50_13440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019467789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alcohol dehydrogenase catalytic domain-containing
                     protein"
                     /protein_id="WP_069794570.1"
                     /translation="MKAVTYQGHKNMEVREVHDPIIEESTDAIIKITASGICGSDLHLY
                     HQGDLFMDPDFVIGHEPMGIVEEVGKEVKTLKKGDRVVIPFNIGCGDCFYCNNEMESQC
                     DNSNPSPASWKMNNGGLFGFGGMHGNHWGGQAEYLRVPFADFSSFKVPDSDLKDEQVLF
                     LSDVVPTAYWSVEHAGVKSGDTVIVLGCGPIGLMAQKFAKLKGAERVIAIDNVEHRLNH
                     AKKSNGAEVYNFSKEDNIGKLLHESTRGGADVVIDCVGMDGQVAQDDLEISSNSAQRGN
                     ISPIITAAESVRKFGTIQLTGIYGTPADNFPIDLIFNRDVQVKSGQAPVIHQMPKLYEM
                     IKNEVFDPTEIITHTMPIEDAKQAYDIFDQKKDNNIKVILKP"
                     /name="alcohol dehydrogenase catalytic domain-containing
                     protein"
     gene            complement(22437..24698)
                     /locus_tag="HSZ50_RS13425"
                     /old_locus_tag="HSZ50_13445"
     CDS             complement(22437..24698)
                     /locus_tag="HSZ50_RS13425"
                     /old_locus_tag="HSZ50_13445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002512582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_069794572.1"
                     /translation="MNDITIIGASQNNLKNINITIPKHLVTVFTGRSGSGKSSLVFRTI
                     AAESEQLLNESYSSYIQFHLNKQPKPKVNAIKNLPVAMTISQKRFNGNSRSTVGTVSDI
                     YASVRLLWSRIGEPFVGYSDAFSFNSPNGMCETCEGLGYIEDINLNELLDWNKSLNEGA
                     INFPSFGPDKERGKAYRDSGLFDNDKKLKAYTKEELDLFLYQEPIKLKKPPEEWRKSAK
                     YVGLIPRFRRIFLGDKEFNKKRYAKHLKNVVENKVCPTCNGQRLNSKILSCKIMGKNIS
                     DFTQMTVKENLAFLNKLNNSTAQFIIEPLRKQLEALDYIGLSYLTLDRVTTSLSGGEAQ
                     RLKLIRHLNSSLSDLVYIIDEPSVGLHPEDTAKINEILKSLKHKGNTVLIVEHDPDVIK
                     EADYIIDMGPSSGAQGGEITFKGTYKKLLSSDTSTGEALRIKHHLKNEIREAKSFYHLG
                     PVTQNNLNNVTVDIPKHVLTVLTGVAGSGKSSLVKAGFAKNDNAVFMDQKAIQGSDRSN
                     LLTYLGVFDRVRNFFSKETGLNKSMFSYNSKGACPNCGGKGYIETELAFMGEFSQTCEV
                     CHGKRYKPEVLNATIDGYSIADFLELTVDEGIRFFDKENEIQSKLQAISKTGLNYVTLG
                     QPLSTLSGGEIQRVKLGQYLNDDVTDSIFIFDEPTTGLHEADIPILINCFNDLIEQNNT
                     VILIEHNLSIMCDADWIIDVGPGPGLDGGKIQFSGYPINFVKENKTLTSKHLKLYIAND
                     "
                     /name="excinuclease ABC subunit UvrA"
     gene            complement(24956..25474)
                     /locus_tag="HSZ50_RS13430"
                     /old_locus_tag="HSZ50_13450"
     CDS             complement(24956..25474)
                     /locus_tag="HSZ50_RS13430"
                     /old_locus_tag="HSZ50_13450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011303361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 1 glutamine amidotransferase
                     domain-containing protein"
                     /protein_id="WP_011303361.1"
                     /translation="MTKKVAIILADEFEDIELTSPKEALENAGFETEVIGDTEKHELVG
                     KHGEKVTVDVSIADAKPENYDALLIPGGFSPDHLRGDEEGRYGTFTKYFTQNDVPTFAI
                     CHGPLLLVDTDDLKGRTITGVINVRKDLSNAGAHVVDESVVIDNNIVTSRVPDDLDDFN
                     REIIKKLKA"
                     /name="type 1 glutamine amidotransferase domain-containing
                     protein"
     gene            complement(25630..26271)
                     /gene="hxlA"
                     /locus_tag="HSZ50_RS13435"
                     /old_locus_tag="HSZ50_13455"
     CDS             complement(25630..26271)
                     /gene="hxlA"
                     /locus_tag="HSZ50_RS13435"
                     /old_locus_tag="HSZ50_13455"
                     /EC_number="4.1.2.43"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002509533.1"
                     /GO_function="GO:0043801 - hexulose-6-phosphate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019647 - formaldehyde assimilation via
                     ribulose monophosphate cycle [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hexulose-6-phosphate synthase"
                     /protein_id="WP_174605062.1"
                     /translation="MELQLAIDLLNKEDAAELANKVKDYVDIVEIGTPIVINEGLPAVQ
                     HLNDNIDSVKVLADLKIMDAADYEVSQAVKFGADIVTILGVAEDASIKAAVDEAHKHGK
                     QLLVDMIAVQDLEKRAKDLDDLGADYIAVHTGYDLQAEGQSPLESLRKVKSVISNSKVA
                     VAGGIKPDTIKDIVAENPDLIIVGGGIANADDPVEAAKQCRDIVDAHTKA"
                     /name="hxlA"
     gene            26533..27465
                     /locus_tag="HSZ50_RS13440"
                     /old_locus_tag="HSZ50_13460"
     CDS             26533..27465
                     /locus_tag="HSZ50_RS13440"
                     /old_locus_tag="HSZ50_13460"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002508658.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_040030456.1"
                     /translation="MRAFAIESYGEADVLQEFNLPLPEITDEEVLIEVENTGISPYDWH
                     VRRGEQEGKIDYPIPLILGWDISGVIRKVGSKVTDLTVGTPVIATQQLDKNGGYAEFVA
                     INQNTVVKKPESLSFEEGATIPINGLTVYQALIKYGEMQHGDKVLIHSGAGAVGIFGIQ
                     LAKAKGAYVATTASTHNHEFLKSIGADVTIDYNTERFEDYVHDYDIVLDTQAGETLERS
                     YDVLKPGGRLISIRGQVNKKKAESKGITAYFTWTELNRQDLIEVVNLYGYGVVKAYFEA
                     IFPLSFVREAHKLSENGHSRGKIVINNKS"
                     /name="NADP-dependent oxidoreductase"
     gene            complement(27566..28300)
                     /locus_tag="HSZ50_RS13445"
                     /old_locus_tag="HSZ50_13465"
     CDS             complement(27566..28300)
                     /locus_tag="HSZ50_RS13445"
                     /old_locus_tag="HSZ50_13465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_040030455.1"
                     /translation="MRSVKALSEELEVSKQTIFNNIKRLNIETIKQENTSFIKEDSDIE
                     KIVQRVNENKKKYGFENVAESKQKKDPDNIDVESKTDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIKKLEDQLEEERRLNYSFDTSVNER
                     QNVNVQEATFTGESKDTDQQQEWEQPTEVQHKDIPEEKENENLNEEPSTIDDKQFEEID
                     NEYEDKEEKPPKKGFWSRLFGN"
                     /name="DUF536 domain-containing protein"
     Typing          1104..1291
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="97.884"
                     /coverage="100.0"
                     /evalue="2.17e-87"
ORIGIN
        1 atgcctagaa aaaatataaa aaatcaagcc aatcaaaatt tctatatgct acataaagtt
       61 ttatttatca acgaaaaata taaaaagcta agtgatagtg ctaaagttac ctatgcaatt
      121 cttaatgata gagttagttt atctattaaa aataattgga tagatcaaaa tggagatata
      181 tactttattt ttactaatga aaatcttcaa gaagtgttag ataaaagtaa aaatacaata
      241 actaaaataa aaaaagagtt acaagaggtt ggtttactgg aacaagttaa aaccgggttt
      301 aatcgaccga acaaactata tcttcatgaa atagaaacga atataactat tgaaaaagaa
      361 atacaaaata gtacttcgaa cgatgacgaa tcgagtgata tcaaggactc ccaaatattg
      421 ggactccaga atcccaaaca atgggactcc agaatcccaa atgatgggac tccagaatcc
      481 caaaacttag accctaatga tactgaattt agtaatactg attatataga gactgagaac
      541 aatgatacga atgatttgaa tgatacacct aacaatattt ctgaaaacgc tcattcgaat
      601 catacaaatc atcaacaaac tgaatttaat aatgatgcct taaaattcca agtgcttgaa
      661 gaattgccac aacaaatcaa agattattta agtaattttg aaattagaga aattcatatt
      721 attaaaagtg ttttactcaa agggaagaaa tcatttaata atgcacatga tacctattat
      781 cgtttagaag atgttgagtt tgaaattgtc agtgtcttaa aacgttttaa agcgatgctg
      841 ctacaaaaga atgaaaccgt tgaagctatg caaggatatt taatgcaatc gattaaagct
      901 gaacttgaag aaatacacgc acttaatatg cgtcgtcaaa acatgaaaca acataatatc
      961 tttaaccaat aatttagata attttatagc tatcaaagaa acctctaaat attcggttaa
     1021 gtcatctgat tttttaactg atgatgatga aagaaatcaa gaaatcgtga atgatttaga
     1081 aaaaggttta tatcgaaaac gtatgttgag ttatggtggt ttgcttaaac aaaaacataa
     1141 gattttaaat ttagatgatg ccgaagatgg caatttgatt aatacaagtg acgaagataa
     1201 aacaacagac gaagaagaaa aagcacattc aattacggca atttggaatt ttgaaaaaca
     1261 aaattattat ttaaaagatt tgaaacgtta gctaaaaagc tagcgttttt ttatgtcttt
     1321 ttgcccctgc gggaactata gcgttcaacc ggcatggttg accagttttc atgttaactt
     1381 ttaagtttgc atgtaaatgg gcagtgtcta aaaaattagt cactggtttt gctcaaattt
     1441 ttgtttgtga aattaagata tatttatttg gctcatattt gcgttttaaa agcgtatata
     1501 gacttttagg tataaaacta tatgaattac ccctaaatct ttaaaatgcc cccttaaaat
     1561 tcaaataaag gtatttaaaa ttttaaaaat aaaaaagcta ctagcaaaaa ctagtagctt
     1621 aaatcttagt taaattttga tgtagtatta atttttgtat ctgcgccaca acgccgatta
     1681 ctaataatgc agtattaatt tttatatctg tgctgcaaca ccgattactt aaaactaaga
     1741 ttaaaaaaat cgacgaaggt cgattatggt tttgcacacg tcgatttatc cgacgtgtaa
     1801 gtgcgccctt acgggattta actagattat aacgacgaaa atcagacctg taaagcgata
     1861 actattgtga taaagtttgc taaaaaggag ttttgaagtt gaaaaaaaca gaacgtaatt
     1921 tattttctat tttcttatct ttaggaagtc tttttgctat ctttagtggt ttctttattt
     1981 tgggcattgg aatgttaatt ggtggagcaa ctttattaac taaaagtatt tctgaagaat
     2041 aaaagagttg acgcatttat gccgagaaaa tttattgtgc gttgagaaga acccttaact
     2101 aaacttggag acgaatgtcg gcatagcgtg agctattaag ccgaccattc gacaagtttt
     2161 gggattgtta agggttccga ggctcaacgt caataaagca attggaataa agcaattatg
     2221 ttaatttaag aattgtggag gtgtaagtat caagaataaa ctttttaagg caattaaaga
     2281 cgttatcgtt attatcttaa ttattttttt agtagcgact gtgttaaatt acatggattt
     2341 aaatattagt ttaaataaat attggagtaa acttggaaat ttaggattaa taaatattta
     2401 cgaaaataat aatttgaatg ggttggtaac attaggtttt atattagctg gattatcttt
     2461 tgtttacgat atgttattta agaaagagtc taaagaggtt aaacaaaaat aagagaagtt
     2521 taattggttt tgattttggg ttttgaaacg agttgaaaac gagtttcttc ttgtcttgat
     2581 aatggggaga ttaatttaat ccgtttttaa attttagcat ggaatctaat attgataata
     2641 gaacttatcg tttcattatt tcagttaacc gtaatggttt taaaggtagt aaaatgttat
     2701 aatatagatg tattgaagga ggagtggcga ctcctcctaa aaagttaatt tagtttatta
     2761 acgctttaat tagtgatgta atagctctta acagattgat taatgctgtt aggagcttta
     2821 ttttttactc ttttagacat tcatcattat acctctttta acaaatatga ctgcaaccta
     2881 atcatacttt tgctatatct tcatttcatt aacaatatgt tcccctacta ctatattacc
     2941 cattgaatca ttttgagttt ataattcact ttctttaagt cttttttaat tctataaatt
     3001 tcattttatt aatgaatgtt tatttaactg ttacattaat accaaactaa gacttacgca
     3061 ttgtatcgtg taaattattt taatcgtttg ttaaatttac agggaatcta aaaggaatcc
     3121 gggacaacag gataaggagg aacaatgcca ttgccatggc acccagcata gctggggttc
     3181 tctaaactta tctttaaagg atctaaatac tgatattgca gtatttatgg atcatattta
     3241 aaaaacggac acaaaagaat ccatgaaatt ttacatggca ttttctttgg aaaatagtgg
     3301 ttcttctatc ctttggggcg caagggatct cataacaggg aatctttaga atccctaaag
     3361 attccccgaa ggattcctta tgttcatcca aaattaatca atatttcagt acataactaa
     3421 ttagtaatta ctaagttaaa tatgatacga taaaactaag taattgctaa gctaataact
     3481 tgttaaaata gatgagtatt tgcttagttt attttttata aaaacattga gtaattacta
     3541 actatattat tgaatgaata aatgagtgat tacttagtta cggaggggtc aaaaatgact
     3601 aataaaagtc atagaaaagc taaaacaatc aatatcaatt tgactgaaga agaatataaa
     3661 aaggtaaaag cgttagcaga agatagagat ttaaatccaa cagcttatac acgacttgcg
     3721 gcattaggta atcgtatcaa acctacagtt gtctataaca cagatgaata tactgaacag
     3781 ttaaaaaaag aaaaacaaac acttgaaatg gctttagaga caagcgtacc aaaagaagat
     3841 gttgaacttt tagaagcaca atgtgaaagt tataaaactt atattgatac attcaagaag
     3901 ttcttgcagt atgtacaaga agatgcggaa tatattaatt tgaatggata caagagagat
     3961 gaacaattaa aagcagaaat gaaagatgct attaaatcct tttttgaaaa ctgatttaat
     4021 ttttcaaaga tataaaacat acgaatgtaa gttatattac attttgaaat tttcgttctc
     4081 atccacacga ttaaaactgt gggctttctc actcactaaa ttctgtaata catttattag
     4141 aggtcgccag aagagaaaac tcggcactta agtaccgaga tgaatcattg tcttgggcga
     4201 cctgcattat atttggttaa ttgattttga atatatgttt gcacaacatc ttttgacata
     4261 ttacctagcg tagccatgaa aaaacttggt gaccatagat gcccttgcca aagtttttct
     4321 ttcgtttcag gatattgttt aaaccacgct cgagccgaac gacctttgag tgtcttaaca
     4381 atagaactcg gggcatgttt aggattgaag ctaatcatca tatgaatatg atctggtaac
     4441 acttctattt cattaatgat gatttcatga ttctctgcaa tagattgaag tatttgcttc
     4501 ataactttac gtttgctttc atcatcaaat attgatgctc gatatttggt tacccatact
     4561 aaatgaaagt taaaatcata aacatttgtc cttgttttta ctaacatatg tatacctcct
     4621 aagtacatta attataacac ataagagact taaatattaa tcatatgtat gatataataa
     4681 gtttaagaaa taatgaggtg atttgttatg tataaaggtg ttgaatgtaa attatatccc
     4741 aatgaaaaac aagctaatac aatacaaatg accttgggtc atacaaggtt tgtatggaat
     4801 caaatgttaa gtatgttaaa tgaacgctat cgtaataata aagatttaaa aatgttaagt
     4861 tattcaactt tgtcttcgct aattcctcaa ttgaaaagag aatatgcatg gttaaatgat
     4921 gtagacagtg tagctataca atgtgctgtt aaaacattgt ctgagacatt tgaccgtttc
     4981 tttaaaggct attgtcgcta ccctaaattt aaatccagaa aaaataacag gcaatcttat
     5041 ttaagcacga tccgaggcaa caatattaga ttcaatcata atcaaagata tattaaattg
     5101 cctaaattag cctgggtaaa gtgtaaatca agtttgaagc atatcgaaaa cgagcgtatc
     5161 aagtcagtaa cgattaaaca aaacgcaaca ggtcagtatt atatgtctgt attggtaact
     5221 agcgaaaatc aagcattacc aaaaacagga aagtatttag gtattgactt aggtgtttct
     5281 gatttagcca ttacgtcaga tggccaaaaa tatcgctctc aaaaattaca cttaaaatat
     5341 caaaaacaat tacatttttg ggaaaagcga ttagctagaa gacgattgaa agcaaaagcc
     5401 gaaggcattg cattagtaga cactaaaaac tatcaaaagg caagacaaca tgttgcacgt
     5461 atccacgaaa aaatagctaa tactagaaaa gactatctac ataaaataac gactgaactt
     5521 gttgaaaact atgatgttat tgtgatcgaa gacttaaaaa ctaacaatat gattaaaaat
     5581 cataaacttg caagaagtat cgctagtcaa tcatggagac aattcagagt atttttagag
     5641 tataagtgtg caatgtatga caaacaatgt gtcgttgtta atccttacaa aacatcacaa
     5701 aaatgttcac attgtggttt tgatagtggt aaaaaagatt tagacataag aaaatggtca
     5761 tgcccaaaat gtaatgtgga acatgaccga gatattaatg cagcaaaaaa tataatgcac
     5821 attggcttgg aacaagcctt agttaaataa cttagaccgc tgttttactt tgaaataagt
     5881 aaaacaagtc atgagtgttc ctagaaactc gttactttag taacgatgta gttcatgaat
     5941 taacatctat gaatagtaaa actgaaatta gatcaaatga taaaccaaaa taggaaggat
     6001 cactttatta tggtagtgcc tagaaaaatt aaacaaatag aaggtatata aaagaaacta
     6061 aatcagttat ataaaaacat taactttgaa gaattgaatt atggagaagt taaaattgat
     6121 gaaaattcaa actttatatt agataaagaa aacgaaataa tacgttataa agaagattat
     6181 ctatcacaat aaactactga gaaaatgctc aattcataaa acaattaatc aataaagatg
     6241 atacaaacaa attaataact aatgacaata acaataaaga taatcaaata aatgaagatg
     6301 taaatacatt tatttaaaca ttaagtgttc agttaaatat tttaactgaa cactttttta
     6361 ttctggtacc gttaatgtat caacataagt tactacataa aaataatttc aaaggttaat
     6421 ttaagacgaa taaattatgt gaacaataca tgttaagtat ttcacaaata gtcgttaatt
     6481 taaataaaat acataaaatc cagactcctt tagggagtct ataacgactc taaagagtcc
     6541 tcgtttttaa acctcttgtg ggacaaggga tatgccgttc ggtaaatgct cataaaaatg
     6601 ccatgtaaaa atacacaaac tctattgtta tagtgttata aattattata taaacactat
     6661 cacatcagta tttatagtgt taaaggataa gtttagagaa ccccagctat gctgggggcc
     6721 atggcaatgg cattgttcct ccttatcctg ttatcaggga gtctaaaagg agtcgctgat
     6781 ataattaata ggcaagaata aacaatataa gttgttctat taattaccat taatataatg
     6841 ttataagttt tatattaata aactttaatc atcttaattg agttcgttta ttaataaaca
     6901 accaattaat gtatataaaa tgtgacgcta attaggaaca ttttatatac tttaataaat
     6961 caaataacca catttttatt tttgatttat taaatgcaat taaacttagt tataagttaa
     7021 tgcaagaggt ttagtttttg aaatactaat taaatgttat aaaaaagagg aatctataca
     7081 taatataaat tcctctaaag atatttgaaa tatactttat taacttaatg catcttttac
     7141 atcacttgta ggtaaaagag aactatatta atagttccct aaataatttc atcaatccgt
     7201 ttcatttgtt ttactgcatc atttttaaaa ttaacactca tatatgaatt gaaaccactt
     7261 tttatttttc cgattatagc atgtggttct gttatattta ttttatccaa ccaatttagt
     7321 aatgatatat aatcaaatac atcaatatga ttaattaatc tttcatatct taaatttcga
     7381 tttattattt actagtgatt atttagtaat aaaggccaaa aaaataacca tccaacttta
     7441 gccggttaat ggttattttt agataaataa taaggctacc gtctttcgaa cgggctcatt
     7501 tagcaacatg ttagcgcatg ttgtcctttt tctatacaaa ttaataataa cattgtatta
     7561 cataaatccc aatatcttat tttaatatat aacccataat taaaaattag ttacttttat
     7621 tcataatgtg accatgcaga aaggataaaa acttccttat catcttcatc aactgtataa
     7681 acaactctat gttgatggtt tattcttctt gaatagcgct ctaagtgttt aggttgcaac
     7741 ttttcaaaag attgactcgg aaaataaggg tcttctttta acgtgtctac aatttttaag
     7801 aattgtgttt tcaactgcga ttgtttaatt ttctttaaat cagattttgc tgaattttta
     7861 atagaaatac tgtaattatc catttagagg ttgtcccagt ctatatcatc aatattagtg
     7921 tagccactgt tatccttttc acgctctcgt actttatcca tagtccctgt ggtttcaaga
     7981 tataatgttt cttgaatact atcccaatct ttttggctta taattacggc gttattttca
     8041 ctcttagaac tgcttataat aacgggttcg tggctatcat taacttgttt aagtagttca
     8101 tagaattctt ttctagcatt agtaggcgtt ttaatattca ttattagtca cgtcctttct
     8161 ttatcctata ttataacgta cttaaaaacg tacgtaaagt tatgacctat aatggggtat
     8221 aagtttgatt tttacataat tcaacttatc ggaagttatc tgtcatcata tattcgaaga
     8281 tgatataata tataggtcgc ctatctctca ggcgtcaatt tagacgcaga gaggaggtgc
     8341 atatcagatg atcgaagctc ttgttcacat cacgaccaca gtcatcagtg gttgtattgt
     8401 tgcgttattt acgcattggc tacgtacacg taacaataag aaaaagtagg cgatattagc
     8461 caacacctaa aaatcccctc actactcgca atagtgaggg gattggtgca tataatgcac
     8521 gaagctcttg ttaacttaat tataacattg attagtaaag taatgcaaag tactcattca
     8581 tttctctttt gaatactatt tctatctata aactaagtcg tctttacgga taaaaacatt
     8641 gtaacttagc ataacattgt ttaactcata tgcattatta gggcataaat caagcaggta
     8701 tatttttcgt tataagctca tatttacgtt ttatagatta ttccaccatt caaagttatc
     8761 ttgtttaagt aattgatcgc tttctttagg tccaaaactt cctggtttat actgtggtat
     8821 tgttacgtta gattttttcc attcagtact tatataatct ataaattccc atgaatgttt
     8881 aagttcttcc caatgtacaa aattagtttg atttcctatt aaagcatcac atataagtga
     8941 ttcataagca tccactactt ggtttttatc tattgagtta taaattttca tattatgact
     9001 tctattattt ctatttgatt tattttcata aatatatagt gatattttgg cattaggttc
     9061 tatatttatt accagtaaat tacaatcagt atcctcatta ttattttcat atcttaatgt
     9121 attattgttt tttttgaatt ctataacaat ctctgttgct tttttaccta agcgtttccc
     9181 cgtacgaata taaaatggag tcccttccca tcttctatta ttgataagta cttttcctgc
     9241 tacaaatgtt tctgttgttg aatcactatc aacacctttt tcttcatgat atgacattat
     9301 cggagtttca ttaataatac cattaatata ttgtcctcta acaaaatatt tgtgtacatc
     9361 agcccctttc aaaaatttta tattgtttaa aagttcgatt ttttttagtc taatatcttt
     9421 actatttctg ctttcgggtt tctccatagc aataagagta agtatttgta gtgcatgatt
     9481 ttgcaccata tctttaagcg ctcctgtaga atcatagtat tggcctctat cttcaatgcc
     9541 taaagtttcc gatagagtta tttgaacatt tgatatatac ttgttgttcc acaatggttc
     9601 aaatattgta ttaccaaaac gtaaagattc aatattttgc accatctctt tacctagata
     9661 atgatctatt ctaaatattt cttcttcttt aaaatactgt cttatgtgtt tatttaagtc
     9721 ttcagcagat ttcaaatctt ttccaaatgg tttttcgatt attaatcttg aaaatccatt
     9781 tgtatcagaa agacctgatt ggcttatgct ttgagttata attttaaaaa attgaggatt
     9841 cattgctaag taaaataatc tattgccatc caaacaatat tttttatcaa tatcattgga
     9901 aagttccttt aatttattcc aacttgtttt atcttcaaca ttttgttgaa agtaaaatat
     9961 gttatctaaa aataagttca ccatttcaaa attttctcgg cttaataaaa tttgttttac
    10021 tttacttcta tattcttcat cacttatatc ctctaaaccc gtagaaatga taactaattt
    10081 cttaaagtga ccctttttat aaagattaaa aatagaaggt agcaatttcc tgtaacttaa
    10141 atctcctgtt ccgccaaata ttgttattaa tgatgataaa tttttatcca aagcagttcc
    10201 ccccttttac ttgattagct agtttctggt tttcattccg taacagtaat tatattactc
    10261 ttcatcccat tgtgtgtgga acacaccttc atgatcttta cgttcataag tatgtgcacc
    10321 aaaatagtca cgttgtgctt ggataagatt agcaggtaaa tcttcagaac gataactatc
    10381 atagtagttc acacttgcag agaatcctgg tgttggtaca ccgtttttaa cgcctgttgc
    10441 tacgacgtct cttaatgcct cttggtaatc tgtaacaata tttttgaagt atggatctaa
    10501 taataagttt tcaagttctg gattattatc gtaagcatct ttaatttttt gtaagaattg
    10561 tgcacgaatg atacaaccct cacgccaaat cattgcaaga tcacctaatt ttaagttcca
    10621 ttcgtgatct tcgctcgatt ttctcatttg cgcaaagcct tgagcgtaag aacaaatctt
    10681 actcatatat aatgcttttc tgattttttc taagaattct tctttattac catcaaatga
    10741 agcttgtggt ccatttaatg atttagacgc gttaacacgt tcttctttaa tggatgaaat
    10801 gaaacgagca aatactgatt cagtgataat tgttaatgga attcctaatt ctaatgcatt
    10861 aatagaagtc cacttacctg tacctttttg accagcagta tctaatattt tttctactaa
    10921 aggttcatta ttttcatcta attcagtgaa aatatcacca gtaatttcta ttaagtaact
    10981 ttcgagttct ccagcattcc aatctttgaa tgtttgagaa atttcagtat gactcatacc
    11041 taataagtct ttcatcattg cataactttc agcgattaat tgcatatctg catattcaat
    11101 accgttatgg accattttca cataatgacc tgcaccattt gggccaatgt atgttacgca
    11161 agatgcgcca tcttgcgctt tagctgaaat ggcatctaag atatcactga ctttattata
    11221 agcggcttct tgaccgccag gcattaatga aggaccagtt aaagcgccta cttcaccacc
    11281 tgaaacgccc ataccgatga aattaacgcc actttcagct aatgctttat ttcgacgaat
    11341 tgtatcttga tagtttgtat taccaccatc aattaaaata tcatcatcat ctaacagcgg
    11401 aagtagtgta tttatcatat tatccgtagg actcccggcc ttaatcatca acaaaatttt
    11461 acggggtttt tctaatgaat ctacaaattc tttcaagtta tacgcaggat atatcttttg
    11521 ataatgagac ttttgaatag tatcattaat ttcattatta tctctactat gaatactcac
    11581 agaatatttc ttatcctcga tgttccacgc aagatttttc cccataacac ctaaacctaa
    11641 aattccaata ttactagaca ttgtatcctc tcatttcttt atagtttata acctacaatc
    11701 ttgcttcaag atcttttttc atatcttcaa atcctggttt accaagtaaa gcaaacatat
    11761 tttgtttata cgcttctaca ccaggttgat tgaatggatt gacgcctaat tgataaccac
    11821 tcatagcaca tacaagttca aagaagtaca cgacatagcc aaatgtttct tcatctaatt
    11881 gtggaatatt aacaacgata ttaggtacgc caccatcagt atgtgctaat aatgtacctt
    11941 caaatgcttt tgtattaact tcatcaattg ttttaccagc aagataattt aatccatcta
    12001 aatcgtcact atcttcttca atagtaagat catgttttgg atgattcact ttaacaactg
    12061 tttcaaataa gaaacgacga ccttcttgaa cgtattgtcc taatgaatgt aaatcagtag
    12121 tgtagttagc acttgaagga taaatacctt taaagtcttt accttctgat tcaccaaata
    12181 attgtttcca ccattcattg aaatattgca ttgacggttc atagttgata agcatttcag
    12241 ttgtataacc tttgctatat agaaggttac ggattgttgc atattgataa gcaatatttt
    12301 cttctaattt gtcagaagat aattctttac gtgcttttgc tgcaccaatc atcatcgctt
    12361 caatattaat acctgcagct gcgattggta ataaacctac agcagttaac actgaataac
    12421 ggccacctac atcatcagga actacaaatg tttcataacc ttcatttgta gctaattgtt
    12481 ttaatgcacc tttttgttta tctgttgtag caaagatacg ttttttagct tcttctttgc
    12541 catatttatt ctcaactaat tgtttgaata aacggaatgc aactgctggt tctgtagttg
    12601 taccagattt agaaatgacg tttacagaga aatctttgtc agctaaataa tctactaatt
    12661 cttttgtata gcttgatgat aaatggttac ctacaaaaac aatttcagga tagtcattat
    12721 ttgttctaaa tgaagatgtt agcatttcaa tagcagcacg tgcaccaagg tatgagccac
    12781 caataccaat aacaactaac acgtcagaat ttgctttaat acgtttagaa gcttctacaa
    12841 ttcttgaaaa ctcttcttta tcataatcaa ctggaaggtc tacccaaccc aagaaatcat
    12901 ttcctgcacc agttcctcca tgtatcgttt tgtgtaatgt cttcacgata tctttttgtt
    12961 gttctaattc atgttctcca aaaaattcta aagtcttacc ataatctaat tgaatatgag
    13021 tcatctaaaa agcctccaaa tttgtaatta ttagtcttat atttacaatt ccaactgtac
    13081 actacagtgt aatattattc atactgaaaa aatagtcacc ccctttagat aagctgacat
    13141 tccctatatg ccaattttgt cagtattgat ttattgataa ttatgtcaaa ataaaggtat
    13201 aaattaatga aaggatgaat tatcgtggaa ttacaattag ctattgattt attaaataaa
    13261 gaagaagcag cagaattagc gaaaaaagta gaagaatatg ttgatattgt agaaattggt
    13321 acaccaattg tgattaacga aggtttacct gccgttcaac atttaaatga aaatataagc
    13381 aatgctaaag tattagcaga cttaaaaatc atggatgcag cagactatga agtaagccaa
    13441 gctgttaaat tcggcgctga tgttgtaaca attttaggtg tagcagaaga tgcgtcaatt
    13501 aaagcagcag ttgaagaagc acataaaaat aacaaacaat tattagtaga tatgattgct
    13561 gttcaagatt tagaaaaacg tgcgaaagaa ttagatgaaa tgggtgctga ctatattgca
    13621 gtgcacactg gttatgattt acaagctgaa ggacaatctc cattagatag cttacgtaaa
    13681 gttaaatcag taattaaaaa ttctaaagtc gcagttgctg gtggtattaa accagataca
    13741 attaaagaaa ttgttgcaga agaacctgac ttagtaattg ttggtggcgg tatcgcaaat
    13801 gctgatgacc ctgtagaagc agctaaacaa tgtcgtgacg ctattgaagg taaataatga
    13861 tgacaacttt taatcattat caattaattt tagatgagtt aaagggcact ttatctcatg
    13921 ttaaagatga agaatttgat gggtttgtat cagaagtaac tgaagcatca cgcatattta
    13981 ttgcaggtaa ggggcgttct ggattcgttg caaacagttt tgcaatgaga ctcaatcaat
    14041 taggaaagca agcatttgtc attggcgaat caacaacacc atcaattcaa aaagatgatt
    14101 tatttattgt aatttctggt tcaggctcaa cagaacatct tcgcttatta gcagaaaaag
    14161 cgaaatcagt tgatgcaaaa gtggtattac taacaactaa actagattct gcaattggtg
    14221 aaattgcaga cacagtagtt gaattaccag caggtacaaa acacgatgct actgggtctg
    14281 atcaaccgtt aggtagtttg tttgaacaat catcacaaat ctttttagat agtgtagtca
    14341 ttggactaat gacacaatta gatgttgagg aaacaactat gcaaaataat catgccaatt
    14401 tagaatagat ataaataagc agttaatgcg gaagattata taatcttccg cattaacaat
    14461 gtaaattcta atatatagaa gaaagaagga tgaaaattgt attataaagg aaaagaattt
    14521 ttcacttcta aagatttagc tttatgtgtt atcggaggaa agtggaagat ccctataatt
    14581 tttcatttac ttcaagacaa agtattgaga ttaagtgagc tacaaaaaaa gttgccgcat
    14641 gtcaatcaaa ggatgctaat aagacaactt agagaattag aagaggacca aattattgaa
    14701 agacatattt attctgtagt tcccccaaaa gtggagtata agctgacatc tataggctac
    14761 aagctagata aggtggttta tgcaatatgt gaatggggtg atttattcaa ggatgaaata
    14821 atacattaaa aagttctggt gcaaattaaa aataaagtta actactctct tataatgtaa
    14881 gtattcaatt agctgactaa catgtattaa tttcgccgtt ctatgaaatt aagggttctg
    14941 ttgcaaagtt agataaatat agctaatcac cattttattg tgtcagtctt cgcctaacca
    15001 gctaacatat aactaatttc gtggcatggt gaaaatccgt agatctgaag agacctacgg
    15061 tttttttata taatccgtaa atacattcaa tgcctttgag tgtatttttt gccgtattga
    15121 cactttgata tcttgtcttt ctcaccttaa tgtgacgatg atcttgttca atgaagttat
    15181 tgagatattt agatgtgcaa tgacagttag gtttcaactt aaacacttta attattttag
    15241 ccatggctac cttcgttgaa ggtgcttgat ctgtaattat catttgaggt ttaccgaatt
    15301 gtttaataag gcgcttaata aacgcatatg ctgattgatg atctcgtttt ttgcgtaacc
    15361 aaatatctaa tgtatgtcca tctgcatcaa tcgcgcgata cagataacac cactgtcctt
    15421 taattttgat atatgtctca tcaacacgcc acttataata cgctttttta tgttttttct
    15481 tccaaatttg atacaaaacg ggagcatatt cttgaaccca acggtagacc gttgaatgat
    15541 gaacgttgac accacgttct cttagtattt cagatatatc acgataacta agcgcatatc
    15601 ttagatagta gccaacggct acagtgatga cgtccttgtt aaattgttta tatctgaaat
    15661 agttcatata gcatactcct ttttgttaaa attatactac aaaatcaact ttgcaacaga
    15721 accagatcac ttatcagaag ctacctatca tcgtatattc gtagatgata taatatacaa
    15781 gtcgcctatc tctcaggcgt caattccgac gcagagagga ggtgctaatc tatgctagaa
    15841 atccttgttc acatcacgac cacagtcatc agtggttgta ttattgcgtt atttacgcat
    15901 tggctacgta atcgcaataa taaataggcg accatagcca cacctaaaaa atcccctcac
    15961 tattgccgta gtgaggggat tggtgcatct atgctagttt ccttgttaac taaattataa
    16021 catcggtgag tggagaaatg caaagtcctc attcatttct cttttgaata ttatttctat
    16081 ctataatcta actcgtcttt acggataaaa acattgtaac ttggcataac attgtttaac
    16141 ttatggttac ttttttgtaa atctatacca cacttattaa gtatagcttt catgataatt
    16201 cgatctgatt ctttaatatc catataatct tcagacatat ttttataagg tgaattgact
    16261 ttaaaagtga tttgtgaaat taaacatgca ttttcaatac tgtccatatg aggatagacg
    16321 ttgcatttta tagcagttcc ttttactaca ctcttttgga gcagtaacca atagttacgt
    16381 aaagattgta gtaaagtgtc ttcaaatgga attagtataa tcgatgataa aaaaactccg
    16441 ataataaacc aaaatccgtt tactatttag ttgcaaattg ctagattcat aagtcacttc
    16501 gcttcctcaa gaattatgat tttattatat catttttacg ctttcagttt atttaatatt
    16561 tataacttta attgtatgat tggcgtacac cctaatcata caaagtagat tgttgaaatt
    16621 acagcaacct acatgtatga ttagggtgta tattaaatat ggagtgaaaa taaatgatta
    16681 taggatatgc gagagtatct tcgatagatc aaaacttaga aagacaattg gataatttaa
    16741 agacgcttgg tgtagagaaa atctttacag agaagcaatc aggaaaatca gttgaaaata
    16801 gacctgtatt tcaagaagcc cttaattttg taagaatggg agatcgattc gttgtggagt
    16861 ctattgatcg tttaggacgt aattatgatg aaattattga aactgtgaat tacttaaaag
    16921 aaaaagacgt tcagttaatg attacaagtt tacctatgat aaatgaagtt attggtaatc
    16981 cattactaga taagtttatg aaagatttaa tcgttcaaat tttagcaatg gtttcagaac
    17041 aagagagaaa tgaaagtaaa cgtcgacaag ctcaaggtat ccaagttgcg aaatacaaag
    17101 gggtatataa agggcgccct ttactttatt caccgaacgc aaaagatcct cagaaacgtg
    17161 ttatctatca tcgagttgtc gaaatgttag aagaagggaa agcaattagt aagattgcga
    17221 aagaggttaa tattacaaga cagacagttt atagaattaa acatgataag ggattatctt
    17281 gataaatggg atgtcaatgc aaatgagcgt ttcttacagc gtctcataat acatgttaat
    17341 catgtattat gagattttaa taataagaca ggaaaaagag agagcaaaaa cgctctctct
    17401 ttttttctat attttttctc aataacgaac gtttttcatt acttctgtta tctcatttaa
    17461 atcaaataaa tctgaagatt tccatgtaac attttgttca ttagacttat tttctatata
    17521 tgatatgctg aagcacctgt taatagaatt tttttgtaaa tttagcctcc aattttaaaa
    17581 atgagcaggc acatgcttgc ctcagctcat ctttttcata ataagctaaa ttgctcacta
    17641 caattaaatt aatttgatat aagtgtggca agagttctac gtctcttaat aaataatacc
    17701 caattttatt gataaatgaa cttaaattta aaattaaatt gatgagtatc agaagtacga
    17761 tttacataaa aaggtacgac aagtttatga gcttgtcgca cctttttaat tacaattagt
    17821 tactaacaaa cgactccaaa agccttttta agttgtgttt attcaccctt ttttcttcct
    17881 aatgttgatt aatatttaca gcgtctgtag tatatgatac ttcttacaca tccacgtttt
    17941 atctatcatt agtaggtgta tcaaaggaat aattaagcag cctctcttcc tctaattaat
    18001 ttttgaatct tttttattac tctctaacgc caaaacttgc tgattcttaa gcaatcttta
    18061 atctttcctg caactctttt ctattctggc tcatatatgc gttttaagaa acaaatgtaa
    18121 ttgaataggt taaaaattat atatttttaa agtttccttt aaaccaactg ttaaaatgta
    18181 taataaggat attggattac cacatgtaaa tttgttttta gcacgacgtt ttttaggtgt
    18241 gtaagtgtgc ctttagatat aaaaataaaa gtcaaactag aaaaagtaga ttgacttttt
    18301 cttttgatgc agtatcgtca atgtaaatct aaaaattctg gctataaatc tacatcactt
    18361 ttcaaaaatg tagtagtgat attcaatact aattagtttt tataactact aggaaatatc
    18421 tcaaggcgtt tctttaaatt aaaaataccc cacaaataaa tgtggagtat taaagtgaat
    18481 catcttttgt aggttttatt ccagattagc atgattttgc tgcattgttt cttcatcaac
    18541 gtttatctca gtcattaaat ctaaaacaat actatctaaa aacacttgtg atgcttgttc
    18601 aaataagcta cctagaggtt gtgctgaacc ttcagcatca tatttcgttc ccgccggtaa
    18661 ttcaatcact gcatttgcaa gttcaccaat atttgacgtt ggatttgttg acaataatac
    18721 aacttctgca cctacagctt tagctttatc tgctaataat cttaaatgct ctgtcgaacc
    18781 tgagccagaa aggataacaa acaaatcttt ttcggtaatg gaaggtgtag tggactcacc
    18841 aactacatgt gcacccttcc caagctgatt caatctcatc gcaaaactat ttgctacaaa
    18901 acccgaacgt ccttttccag atacaaaaac ttgctctgct ttaataattt gctttaaaaa
    18961 cgtttcggct tcactgtctt tcacatgtga taatgtgttg tctatttcat ctagtattaa
    19021 acgataattt gtgatttctg tcatcattat tttccttcaa tcgcagctct acattgttta
    19081 gcagcttcta cagggtcatc agcatttgca atgccgccac caacaataat taaatcagga
    19141 ttttctgcaa caatatcttt aattgtatct ggtttaatac cacctgcgac tgctacttta
    19201 gaattactaa ttacagattt aactttacgt aaactttcta aaggagattg accttcagct
    19261 tgtaagtcat aaccagtatg aacagcgata taatctgcgc ctaaatcatc taaatctttc
    19321 gcacgttttt ctaaatcttg gactgcaatc atatctacta ataattgttt gccatgttta
    19381 tgtgcttcat caactgctgc tttaattgat gcatcttctg caacgcctaa aattgttact
    19441 atgtctgcac caaatttaac tgcttggctt acttcatagt cggcagcatc cataattttt
    19501 aaatctgcta atacttttac actatcaata ttatcattta aatgttgtac agctggtaat
    19561 ccttcattta taacaatcgg tgttccaatt tctacgatat ctacataatc tttaacttta
    19621 tttgctaatt ctgcagcatc ctctttattt aataaatcaa tcgctaattg taattccata
    19681 tgttattacc tcctatatat tatatattca ttatggtata ataactttgg aaatacaata
    19741 ctgacaaata tgtcactgag gagaagaaat tgttaataga atataataat aaattatttt
    19801 acacttctaa agatttagct ttatcagtaa ttggtggtag gtggaaaatc cctattattt
    19861 atcatttatt acaatcagaa gtacttaggt tgagtgaatt agaaaaaaaa ttaccagata
    19921 ttaatcaaag aatgttaatt agacaattaa gggagcttga aaaggatatg ataataaaaa
    19981 gaactatata tccagtagtc cctccaaaag ttgaatatcg attaactagt gttggtttgt
    20041 ctctcgacaa tgtggtctat ggtatttgtg aatggggaga tgaatatttg aaattaatta
    20101 ataatgaaaa ttagttagtt ttttaaaaga agaaaaattg aaccgaactt tatataatct
    20161 ctttcagata ttgatatgtt tttatattga ctagtagatc gatataaata gagaacgact
    20221 caaagacaca taagtacgct ctaaacacac aaaatatttt tctgatatta atagtgtata
    20281 tagggtcatt agattctata ttaaaaaagg cgaagtataa ttatacttcg ctttaagtta
    20341 atctttataa tgattacttg tatttttgtc aaaccatgct ttttcaagca gtttaactgc
    20401 tgcttttatt tgttctatgg atagtactgc aaagccaagg aggacggttt ggccatcatt
    20461 tcaattactt ggttaaatga gtcctttgga tactatcaac tagtagacgg actatttatt
    20521 attatagctg tcgtagcttt aactacaccg aaaaaaagta agtatgaaaa ttaaacaaat
    20581 ttttcaaaat ttttaagcta taaagtagta taaaaaagat atttctttat aaagagtgtc
    20641 ttaatcattt caaaacatgc tcgttaacga atatatcttg atctatacat tttttatctc
    20701 tcttttctta tgaggtactt tatattttcg agaatcttcc atagtttgta agtaacttaa
    20761 tttcccaaaa agtagcaata acataatgtg catttaaatt atcagctttt aaaagcaata
    20821 aacattaaaa tccttcgctt ttcagatttt tatttcggtt taagaaaaca cacaaattct
    20881 tctttaaaat cagcaattac ttataaacgg gtcaaaactg tatagttact tttaggtaaa
    20941 tctttaattt tattctagta tattgcttac atgtattaaa cttatctata attacttttt
    21001 aattaatttt ggctaaataa atacgatgtt tggcattttg ctacatatga actaacaatt
    21061 ttctgaaaag agtaataaat caatttatta ctctgagttt acattataat atcaagggta
    21121 aaatctttag aggaggatgg tacaaatgaa agcagttact tatcaaggtc ataaaaatat
    21181 ggaagtgcgt gaagtacatg atccaataat agaagaatca acggatgcaa ttataaaaat
    21241 aacagcttca ggtatatgtg gttctgattt acatctttac catcaaggtg atttatttat
    21301 ggatcctgat tttgttattg gacatgagcc aatgggaatt gtagaagaag taggaaaaga
    21361 ggttaaaacc ttaaaaaagg gagatagagt agttatacct tttaacatag gttgtggcga
    21421 ttgtttctat tgtaataatg aaatggagtc tcagtgtgat aattctaatc catcaccggc
    21481 aagttggaaa atgaataatg gtggactctt cggttttggt ggcatgcacg gaaaccactg
    21541 gggaggtcaa gcagagtatt tgagagtccc atttgccgat ttctcctctt tcaaagttcc
    21601 agatagtgat ttgaaagacg aacaagtatt atttttatct gatgtggtcc caacagctta
    21661 ttggagtgtt gaacatgcag gcgtaaaatc tggagatacc gttattgttc tcggttgtgg
    21721 cccaatcggt ttaatggcac aaaaatttgc taaattaaaa ggcgctgaac gtgttattgc
    21781 cattgacaat gtagaacata gattaaacca tgccaaaaaa tccaatggcg ctgaagtata
    21841 taatttttct aaagaagata atataggaaa attacttcat gaaagcacac gcggtggtgc
    21901 agatgtcgtt atagattgtg ttggaatgga tggccaagtt gctcaagatg atttagagat
    21961 aagttcaaat tcagcgcaac gaggtaatat tagtcccatt attacagcag ctgaatcagt
    22021 aagaaaattt ggaacgattc aattaactgg tatttacggt acacctgcag acaattttcc
    22081 aatagattta attttcaata gagatgtcca agtaaaaagt ggacaagcgc cagttattca
    22141 tcaaatgcca aaattatatg aaatgattaa aaatgaggtt tttgatccaa cagaaattat
    22201 aactcataca atgcctatag aagatgcaaa acaagcgtat gatattttcg atcagaaaaa
    22261 agataataat attaaagtaa ttctaaaacc ataataataa attaataaag aagtctatat
    22321 acagattata accagtatat agacttcttt attaatttca tgtgataatt ttcagaatcg
    22381 ctaagtttca aaaatttcta aatctaacca atgctctatg aaaatatgaa acaactttaa
    22441 tcatttgcta tataaagttt caaatgctta gatgttaatg ttttattctc tttaacaaag
    22501 tttataggat agccactaaa ttgtatttta cccccatcta gaccaggtcc tggtcctaca
    22561 tctataatcc aatcagcatc acacataatt gataaattgt gttcaattaa aataacagtg
    22621 ttattttgtt caataagatc attaaaacag tttatcaata taggaatatc agcttcatgt
    22681 aaacctgttg taggttcatc aaatataaaa atactatctg taacatcatc atttaaatat
    22741 tggcctaatt taacgcgttg aatttcacca cctgataatg tagatagagg ttggccaagg
    22801 gttacgtaat ttaatccagt tttacttata gcttgtaact tagactgaat ttcattttct
    22861 ttatcaaaaa atcttatacc ttcgtcaaca gtcaattcaa ggaaatcagc aatggaatag
    22921 ccatctatag ttgcattcaa cacttctggc ttataacgtt taccgtgaca cacttcacat
    22981 gtttgtgaaa attcacccat aaatgcaagt tctgtttcaa tataaccttt accaccacaa
    23041 ttgggacaag ctcctttcga attataacta aacatagatt tatttaatcc agtttctttg
    23101 ctgaaaaaat ttctgactct atcaaaaaca cctaaataag ttagtaaatt agaccgatcg
    23161 gaaccttgta tcgctttttg atccataaat actgcattat cattttttgc aaaacctgcc
    23221 ttaacaagtg aacttttccc agaacctgct actccagtta atactgttaa aacatgcttg
    23281 ggtatatcca ctgtcacatt attcaaattg ttttgggtta ctggtccaag atgataaaaa
    23341 ctctttgctt cacgtatctc attttttaag tgatgtttga tacgtagtgc ttccccagta
    23401 gatgtatctg aagacaataa ttttttgtat gttcccttaa acgttatctc tccaccttgc
    23461 gcccctgaac ttggccccat atcaataata taatctgctt ctttaattac atcaggatca
    23521 tgttctacaa ttaatactgt attaccttta tgttttaaag atttcaaaat ttcatttatt
    23581 tttgcagtat cctctggatg taaaccaaca cttggttcat caatgatata aaccaaatca
    23641 gatagcgaac tatttaaatg tcgtattaat ttaagccgtt gtgcttctcc acctgataaa
    23701 gaagtggtta cacggtcaag agttaaataa cttaatccta tataatcaag tgcttctaat
    23761 tgttttcgga gtggttcaat aataaactgg gctgttgaat tatttaattt attaagaaat
    23821 gctaaatttt cttttacagt catttgtgtg aaatctgaaa tatttttccc cataatttta
    23881 caactcaaaa ttttcgaatt taaacgttga ccgttacaag ttggacaaac tttgttttcc
    23941 acaacatttt taagatgttt agcataacgt tttttgttaa attctttatc tcccaagaat
    24001 attcttctaa acctaggtat aagtcccaca tattttgctg atttccgcca ttcttcaggt
    24061 ggttttttta attttattgg ctcctgatac aaaaacaaat ctaattcctc ttttgtatat
    24121 gcttttaatt ttttatcatt atcaaacaga ccactatcac gataagcttt ccctctttct
    24181 ttatcaggtc caaaagatgg aaaattaata gcaccttcat ttaaagattt gttccaatct
    24241 aagagctcat ttaaattaat gtcttcaatg taacctaatc cttcacatgt ttcacacata
    24301 ccattgggac tgttaaatga aaaggcatct gaataaccga caaaaggttc acctatcctt
    24361 gaccataaca atctaacaga ggcgtatata tcagatactg tacctacagt agagcgagaa
    24421 ttaccattaa atcttttttg actaatcgtc attgctacag gaagattttt aattgcattt
    24481 acttttggtt taggctgctt atttaaatga aattgaatgt agctagaata actttcattt
    24541 aaaagttgtt cagattcagc agctattgtt ctgaaaacca atgatgactt acctgaacca
    24601 gaacgacctg taaatactgt aactaaatgt ttaggtatag ttatatttat atttttcaaa
    24661 ttattttgtg aagctcctat aatggtaata tcattcataa attaaattgc cctccattgt
    24721 aatttttaac aattaatagt atagatgaag ttaaaagatt agtagaattt cgaaataggt
    24781 tacattacaa aaacagtatg tagaatatct aatattttat cgtagattat aagttatctt
    24841 aatgaagtta agttcatttt atttttataa aaacctaaca ataagagact aacagcaaaa
    24901 ttataaactt tgctgttagt ctcttagata ataaatactg attgatatta taaaattatg
    24961 cttttaattt tttaataatt tctctattga aatcatctaa gtcatctggg acacgactcg
    25021 ttacaatatt gttatctatt acaactgatt catcaacaac gtgtgcacca gcattagata
    25081 aatctttacg tacattgata acgccagtta ttgtgcggcc ctttaaatca tcagtatcaa
    25141 ctagtagaag tggaccatga caaatcgcaa atgtaggcac atcattttga gtaaaatact
    25201 tagtaaatgt accatagcga ccttcttcat caccacgtaa atgatcaggt gagaatccgc
    25261 caggaattaa taatgcatca taattttctg gtttcgcatc tgcaatgcta acatctacag
    25321 ttactttctc cccatgtttg ccaacaagtt catgtttttc tgtatctcca ataacttcag
    25381 tctcaaatcc agcattttct aatgcttctt ttggactagt caattctata tcttcaaatt
    25441 catctgctaa aatgattgct acttttttag tcataataca acctaccttt caattatatt
    25501 ttaaaaccta agtactatat acactagaaa aaggaagttt aaacataaaa tgttttctaa
    25561 ttttttcaca aactacatgt gcatttttat ctgtttagtt taatcttatt taatattaat
    25621 tgtaactgat tatgcctttg tatgggcatc tacaatatca cgacattgtt tagcagcttc
    25681 tacagggtca tcagcatttg caatgccgcc accaacaata attaaatcag gattttctgc
    25741 aacaatatct ttaattgtat ctggtttaat accacctgcg actgctactt tagaattact
    25801 aattacagat ttaactttac gtaaactttc taaaggagat tgaccttcag cttgtaagtc
    25861 ataaccagta tgaacagcga tataatctgc gcctaaatca tctaaatctt tcgcacgttt
    25921 ttctaaatct tggactgcaa tcatatctac taataattgt ttgccatgtt tatgtgcttc
    25981 atcaactgct gctttaattg atgcatcttc tgcaacgcct aaaattgtta ctatgtctgc
    26041 accaaattta actgcttggc ttacttcata gtcggcagca tccataattt ttaaatctgc
    26101 taatactttt acactatcaa tattatcatt taaatgttgt acagctggta atccttcatt
    26161 tataacgatt ggtgtaccaa tttctacgat atctacataa tctttaactt tatttgctaa
    26221 ttctgcagca tcctctttat ttaataaatc aattgctaat tgtaattcca ttaaaacgcc
    26281 ctcctatcta tcttttatat tatcattatg gtattattta cgacaaataa caatactgac
    26341 atttttgtca ctataaaaat taaagatgtt gtgttgttaa ttaaatataa taataaagat
    26401 tattatatac tcaaatattt agcttttcta taattggtag aagacctgtt gaagacatta
    26461 tagatgaatt aggcgaagaa attgttccat attttccaac acacaaagtg aactaattag
    26521 gaggttatat tgatgagagc atttgcaata gaatcatatg gagaagctga tgtattacaa
    26581 gaatttaatt taccactacc tgagataaca gatgaagaag tattaattga agttgaaaat
    26641 acaggtatta gcccatacga ttggcatgtt agacgaggtg aacaagaagg gaaaattgat
    26701 taccctatac cgctcatttt aggatgggat atatcaggcg ttatacgtaa agtcggctca
    26761 aaagtaacag atttaacagt aggtacacca gttattgcaa cacaacaact tgataaaaac
    26821 ggtggttatg cagaatttgt ggccattaat caaaacacag ttgttaaaaa acctgaatca
    26881 ttatcttttg aagaaggtgc gacaattcca attaatggtt tgactgtcta tcaagcgtta
    26941 ataaaatatg gtgaaatgca acacggcgat aaagtattaa tacatagtgg cgcaggtgca
    27001 gtaggtatat ttggcattca attagctaaa gctaaaggtg cctatgtagc aactactgca
    27061 agtacacaca accatgaatt tttaaaatca attggggcag atgttaccat tgactacaat
    27121 acagaacgtt ttgaagatta tgtacatgat tatgacatcg tccttgatac acaagcagga
    27181 gaaacacttg aacgtagtta tgatgtattg aaacctggag gcagactaat atctatacgc
    27241 ggacaagtta ataaaaagaa agcagaaagt aagggaatta cagcatattt cacatggaca
    27301 gaattaaatc gtcaagattt aatagaagtt gttaatttat atggatatgg tgttgtcaaa
    27361 gcttacttcg aagctatttt cccactatct tttgttcgag aagctcataa attaagtgaa
    27421 aatggtcatt ctagagggaa aattgtaata aataataaat cataatatat gatttattat
    27481 ttaaattaac ataaccgatg attatcagaa gctctagcat aaaaaagcac tacaagttca
    27541 tgagcttgta gcgcttttta ttgtgttaat taccaaacaa ccgactccag aaaccttttt
    27601 taggtggttt ttcttcctta tcttcgtatt cattatctat ttcttcgaat tgtttatcgt
    27661 ctattgtgga tggttcttca ttgaggtttt cattctcttt ctcttcaggt atatctttat
    27721 gctgcacctc tgtaggctgt tcccattctt gttgttgatc agtatcttta gactctccag
    27781 taaatgttgc ttcttgtaca ttaacatttt gtctctcatt aacagacgta tcaaaagaat
    27841 aattaagtcg tctttcttcc tctaattgat cttctaattt tttaatcttt ttattacttt
    27901 ctaatgctaa tacttgttga ttttcaagca atttcgacct ttcttgcaac tcttttctgt
    27961 aaaattcaat tgttgtttca tgacgacttt cttgcttttc aatttgatta ttcaaagtat
    28021 caatctggtt tttaagaatc tccactattt gagcatcagt tttagattca acgtcaatat
    28081 tatctgggtc ttttttttgt ttactttcag caacattttc aaatccatat ttcttcttat
    28141 tttcatttac tctttgaact attttttcta tgtcgctatc ttctttaata aacgaagtgt
    28201 tttcctgttt tattgtttct atattcaatc ttttaatatt attaaaaatt gtttgcttac
    28261 taacttctaa ttcttcactc aaagctttca cgcttctcat atcatcaacc ctttataaaa
    28321 tgtttatcaa ccctttataa aatagtataa actcataaag cttggtaata aagtaattac
    28381 aatattaaaa acggttcccg tcaatcgttt catcaaaggt ttataaaggg ttgatggttt
    28441 ttatcaaagg tttataaacc ctttataaac ctttgataag cctgcatttt cccttttata
    28501 aggttgttca aagtgatata ataaccttaa catgacaaaa ccccaactac tggtaatagt
    28561 cggggtttgg tgataaaacg ttgcagcacg tttataaatc ttttgatatc tgtattatat
    28621 acaactatat catcaaagtg caagcagaaa atttatgtgt tcttgtaatg ttttattacc
    28681 tctatccaaa actttaatag gaaaggggtt tttatt
//
