LOCUS       NZ_CP047827            20731 bp    DNA     circular CON 18-DEC-2023
DEFINITION  Staphylococcus aureus strain UP_1239 plasmid unnamed, complete
            sequence.
ACCESSION   NZ_CP047827
VERSION     NZ_CP047827.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN11175629
            Assembly: GCF_009912355.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 20731)
  AUTHORS   Dilthey,A., Meyer,S. and Kaasch,A.
  TITLE     Increasing the efficiency of long-read sequencing for hybrid
            assembly with k-mer-based multiplexing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 20731)
  AUTHORS   Dilthey,A., Meyer,S. and Kaasch,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JAN-2020) Institute for Medical Microbiology and
            Hospital Hygene, University Hospital Duesseldorf, Moorenstrasse 5,
            Duesseldorf 40225, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: Unicycler Hybrid Assembly v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 43x / 446x
            Sequencing Technology :: Illumina MiSeq / Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 12/17/2023 04:04:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,733
            CDSs (total)                      :: 2,651
            Genes (coding)                    :: 2,582
            CDSs (with protein)               :: 2,582
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 69
            CDSs (without protein)            :: 69
            Pseudo Genes (ambiguous residues) :: 0 of 69
            Pseudo Genes (frameshifted)       :: 37 of 69
            Pseudo Genes (incomplete)         :: 35 of 69
            Pseudo Genes (internal stop)      :: 22 of 69
            Pseudo Genes (multiple problems)  :: 22 of 69
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047827.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..20731
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="UP_1239"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="unnamed"
     gene            166..842
                     /locus_tag="E3T01_RS13725"
                     /pseudo=""
     CDS             166..842
                     /locus_tag="E3T01_RS13725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /name="replication initiator protein A"
     gene            <853..1135
                     /locus_tag="E3T01_RS13820"
                     /old_locus_tag="E3T01_13570"
                     /pseudo=""
     CDS             <853..1135
                     /locus_tag="E3T01_RS13820"
                     /old_locus_tag="E3T01_13570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199895.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            2346..2963
                     /gene="cadD"
                     /locus_tag="E3T01_RS13575"
                     /old_locus_tag="E3T01_13575"
     ARG             2347..2960
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="99.51"
                     /coverage="100.0"
     gene            2982..3329
                     /locus_tag="E3T01_RS13580"
                     /old_locus_tag="E3T01_13580"
     CDS             2982..3329
                     /locus_tag="E3T01_RS13580"
                     /old_locus_tag="E3T01_13580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000119691.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNQEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            3498..3590
                     /locus_tag="E3T01_RS13585"
                     /old_locus_tag="E3T01_13585"
     CDS             3498..3590
                     /locus_tag="E3T01_RS13585"
                     /old_locus_tag="E3T01_13585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001791613.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            3802..4776
                     /locus_tag="E3T01_RS13590"
                     /old_locus_tag="E3T01_13590"
     CDS             3802..4776
                     /locus_tag="E3T01_RS13590"
                     /old_locus_tag="E3T01_13590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4062 domain-containing protein"
                     /protein_id="WP_000072391.1"
                     /translation="MSNTKIKYQIFISSTYLDLIEERQAVVEAVLNSNNIPAGMELFNS
                     SSKSQWEIITQWINESDAVILLLGSSYGTIDSEENISYTEMEYNFAKSLGKPIYVFEMN
                     KASTESAEKSKKLDEFKTKVKENRLISPNINDISELKSKVSQTLMQSVPSEIKENSGWI
                     RVQDCGKNVKKLKKLDAIQRDLDTYDFLKEELYKIFMYVKTFYFQHTPFDDSYIEDIEN
                     YLLNYENNPHKSFMKIKVYDYKNFLKHLKNILILIKQGKKPLAQAGHFKLSFYEEDLKL
                     LQKNYKTTLVDIKGLNKHFYKECDRCLKAYNIFIEGINKHLYE"
                     /name="DUF4062 domain-containing protein"
     gene            complement(4896..5711)
                     /locus_tag="E3T01_RS13595"
                     /old_locus_tag="E3T01_13595"
     CDS             complement(4896..5711)
                     /locus_tag="E3T01_RS13595"
                     /old_locus_tag="E3T01_13595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019467708.1"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WP_000164958.1"
                     /translation="MTKNQNFIETKEYKRFAEFCDACIKYQYIGICYGQPGVGKTLSSR
                     YYTNWDTIEKQVNHRGWEDLASKTTDDILSVDKIFYNAPAEKQTKLRNDLYSITAIIDL
                     GQKLHVVNKYGHEHSKHYSDMFKYIDLIIVDEIDRLKVQHLEQLRAIYDEHNLAMIFIG
                     MPGIEKKLSRYPQLYSRIGFAHEFDNLSKDETHHILEYKWQDLGFDLKLEDFTDYEAIT
                     TIIKITKGNFRLIHRLFAQIDRIMDINGLDKISTEVVETARDSLVIGIR"
                     /name="AAA family ATPase"
     gene            complement(5704..7147)
                     /locus_tag="E3T01_RS13600"
                     /old_locus_tag="E3T01_13600"
                     /pseudo=""
     CDS             complement(5704..7147)
                     /locus_tag="E3T01_RS13600"
                     /old_locus_tag="E3T01_13600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790716.1"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DDE-type integrase/transposase/recombinase"
                     /name="DDE-type integrase/transposase/recombinase"
     gene            complement(7119..7712)
                     /locus_tag="E3T01_RS13605"
                     /old_locus_tag="E3T01_13605"
     CDS             complement(7119..7712)
                     /locus_tag="E3T01_RS13605"
                     /old_locus_tag="E3T01_13605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690636.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690638.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNQKDLNLLKTLYDNGTPI
                     KTIAEQWHVSRTTIYRYLNKLEDKEDEKQGEVSN"
                     /name="recombinase family protein"
     gene            complement(7976..8356)
                     /gene="blaI"
                     /locus_tag="E3T01_RS13610"
                     /old_locus_tag="E3T01_13610"
     ARG             complement(7980..8356)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            complement(8346..10103)
                     /gene="blaR1"
                     /locus_tag="E3T01_RS13615"
                     /old_locus_tag="E3T01_13615"
     ARG             complement(8350..10103)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.56"
                     /coverage="100.0"
     gene            10210..11055
                     /gene="blaZ"
                     /locus_tag="E3T01_RS13620"
                     /old_locus_tag="E3T01_13620"
     ARG             10211..11052
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            11425..12033
                     /locus_tag="E3T01_RS13625"
                     /old_locus_tag="E3T01_13625"
     CDS             11425..12033
                     /locus_tag="E3T01_RS13625"
                     /old_locus_tag="E3T01_13625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002436987.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_044033836.1"
                     /translation="MIVGYARVSSNDQNLERQLENLKTFCAEKIFTEKQSGKSIENRPV
                     LQEALNFLRMGDRFVVESIDCLGRNYDEVIHTVNYLKDKEVQLMITSLPMMNEVVGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGIYKGRPLLYSPNAKDPQKRI
                     IYHRVVEMLEEGQSISKIAKEVNITRQTIYRIKNDNDLI"
                     /name="recombinase family protein"
     gene            12447..12740
                     /locus_tag="E3T01_RS13630"
                     /old_locus_tag="E3T01_13630"
     CDS             12447..12740
                     /locus_tag="E3T01_RS13630"
                     /old_locus_tag="E3T01_13630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_000726502.1"
                     /translation="MKKKFVSSCIASTILFGTLLGVTYKAEAATVHVAGGVWSHGIGKH
                     YVWSYYSHNKRNHGSTAVGKYSSFSGVARPGVQSKASAPKAWGGNKTFYSLH"
                     /name="lactococcin 972 family bacteriocin"
     gene            12815..14749
                     /locus_tag="E3T01_RS13635"
                     /old_locus_tag="E3T01_13635"
     CDS             12815..14749
                     /locus_tag="E3T01_RS13635"
                     /old_locus_tag="E3T01_13635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001670421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="WP_000713729.1"
                     /translation="MKKFKLFLDFSTLLLISGLLFLFFFKENEEIIPESSNILTISNWD
                     KSNSKSKVLDVIESGAKNQNIQIIKSVKDFDNKKEFFVFNSKRNNSDFIRNKTSLLTPS
                     DLLNREIKGKYYIIGEHFNVEELTSELKKAGLTSEVEYINRNILFFELVIDNDLLVPFI
                     FLGVLYLLYFLYDRGYNLKFYAIQKLHGFSTTRIIFHNIHIKIIYWLVLTAIFFIANIL
                     IIHIANLELDFLMFIRRFIVLLFVFACITTLLWLISYSLLLKLSIPLILKGKKGYKFSI
                     FMGTFTKCIMVLILSFLLAQNLNAYTKLKNIYDSEKIWQKLDNYYTLEISPNIRNSEEK
                     QILETNIYNLIKKSEQLGGLLLKNNNIANPDKNNYIPENGNVFFINNNFLNFYKNINHD
                     FKMIDNHSDKINVFIPPRLQYQKSEIQKNHQGWIDFQKQQNKKVDVQVLSKNVSVFSFD
                     RTTNLKFGYLDSPIVMLLTLDDLTGDFYLAAVSQGGYLFKDLDTLKQLLKDNHLEEEIS
                     GITNYKDSVLNELNETKTKMIITIVTIIINVFILLIATVFETIQYFSWNKKQLLLRKIH
                     GYSLFSSNVRYLTISILLSIMLAYTTHILFGSKILLFIIMSIAIIQHLLQIAYIKYLEK
                     YFKDLMREI"
                     /name="bacteriocin-associated integral membrane family
                     protein"
     gene            14753..15064
                     /locus_tag="E3T01_RS13640"
                     /old_locus_tag="E3T01_13640"
     CDS             14753..15064
                     /locus_tag="E3T01_RS13640"
                     /old_locus_tag="E3T01_13640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YxeA family protein"
                     /protein_id="WP_000831610.1"
                     /translation="MKRTLIIVTIVLLIIILSLLLVRNEHLDRFNPLLKEKVSYAKVPK
                     DTQDYRNITVYSKNGEKKSYKLDFLGYDPTKEYVKVNHKGKYVRSIEYITKDIPSFLK"
                     /name="YxeA family protein"
     gene            15076..15702
                     /locus_tag="E3T01_RS13645"
                     /old_locus_tag="E3T01_13645"
     CDS             15076..15702
                     /locus_tag="E3T01_RS13645"
                     /old_locus_tag="E3T01_13645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000593103.1"
                     /translation="MIKLENVFVKKGNKNILDGCNFNFEKGKSYALVGESGAGKSTLLN
                     IIAGFEDVSQGSIYIEDKLLKKKVDFYRYTLGYLFQNFALLENQTISQNLDLALKFKKN
                     KKDNMNLKKEVLKKVGLDLDIKRIVSSLSGGEQQRVALARLILKDPKIILADEPTGSLD
                     TKNGKIVIDLLLKLLDENKTMIVVTHDLELAKRFDVIVNISELRS"
                     /name="ABC transporter ATP-binding protein"
     gene            15940..16569
                     /gene="mobV"
                     /locus_tag="E3T01_RS13825"
                     /pseudo=""
     CDS             15940..16569
                     /gene="mobV"
                     /locus_tag="E3T01_RS13825"
                     /inference="COORDINATES: protein motif:HMM:NF013258.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MobV family relaxase"
                     /name="mobV"
     gene            16663..17208
                     /locus_tag="E3T01_RS13660"
                     /old_locus_tag="E3T01_13660"
     CDS             16663..17208
                     /locus_tag="E3T01_RS13660"
                     /old_locus_tag="E3T01_13660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001805533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000273005.1"
                     /translation="MYEIKTKNVGGWFHKEKQETGNIVITKTDFEKYTKQIKAAQMILD
                     DYECIKSGKSLKKAEKQNESLVNELTSVHMENEKLVEEFNDLAQRYNYLLSENEKKDKE
                     LNYTLKLFNQVFKIIKSMMKEERYHTLINHIDNHLDNSKIREVMTIDNNDEQFFKKKYQ
                     AQEREIIFKEDREDGYTL"
                     /name="hypothetical protein"
     gene            17592..18452
                     /locus_tag="E3T01_RS13665"
                     /old_locus_tag="E3T01_13665"
     CDS             17592..18452
                     /locus_tag="E3T01_RS13665"
                     /old_locus_tag="E3T01_13665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_000145511.1"
                     /translation="MTGETVVYKNEMNLVPLRRFTATEINLFFAMCNKLKEQDTNTLRL
                     SFDELKKLSNYSPETRNINRFANDLDNVYKKMLNLTIRYEDDDVIERFVLFNHYRIHKR
                     EQYLEISTSSNLKHILNSITNNFTKFELKEMTRLKSTYSKNMFRLLKQYKHTGYLKIHI
                     DDFKNRLDIPKSYRMTDINKNVFKPIIIELGSIFNNLTINKIKAKKGRKIEWIEFTFDA
                     EKRIHNKRQPQMSKIDKSRQYVRREKTPKWLEERSYEKQPQKDYDPQLEKEREDFLKQL
                     ELNWE"
                     /name="replication initiation protein"
     gene            18539..18880
                     /locus_tag="E3T01_RS13670"
                     /old_locus_tag="E3T01_13670"
     CDS             18539..18880
                     /locus_tag="E3T01_RS13670"
                     /old_locus_tag="E3T01_13670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761340.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000761341.1"
                     /translation="MKLAEAIKEQRELKGWSQEELANILKVSRQSVSKWESAKNYPSLD
                     ILIAMSDLFGISLEHLIKGDARFKKVILEGNYRESNRVPSIVDFLYDFWWLFFPVAGFL
                     VWAIHSFMG"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(19119..19190)
                     /locus_tag="E3T01_RS13675"
                     /old_locus_tag="E3T01_13675"
     CDS             complement(19119..19190)
                     /locus_tag="E3T01_RS13675"
                     /old_locus_tag="E3T01_13675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_106873653.1"
                     /translation="MNEILVHIMTTAISGCLVTLFGY"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            19339..19524
                     /locus_tag="E3T01_RS13680"
                     /old_locus_tag="E3T01_13680"
     CDS             19339..19524
                     /locus_tag="E3T01_RS13680"
                     /old_locus_tag="E3T01_13680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000466619.1"
                     /translation="MFGDQRQEATKYVIKEGYQDIYFLNKNGEWYYFEVRSVWRGKHII
                     RVKDGLLGWRKEIVTE"
                     /name="hypothetical protein"
     gene            complement(19743..20486)
                     /locus_tag="E3T01_RS13685"
                     /old_locus_tag="E3T01_13685"
     CDS             complement(19743..20486)
                     /locus_tag="E3T01_RS13685"
                     /old_locus_tag="E3T01_13685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_000843758.1"
                     /translation="MKSVKRLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESATEDKQKKESDNINFESKSDAQIVEILKNQINTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNAR
                     QNVDAQEKTYTTSPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAQREDVSANPND
                     NDSDIEEKSEETEPKKGFWSRLFGN"
                     /name="DUF536 domain-containing protein"
     ARG             10211..11055
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     BGC             7447..17740
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          1193..1340
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="81.333"
                     /coverage="100.0"
                     /evalue="2.96e-25"
     Typing          17593..18452
                     /name="rep_cluster_2214"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(19744..20486)
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          15941..16215
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="94.565"
                     /coverage="100.0"
                     /evalue="4.71e-46"
ORIGIN
        1 ttggtaataa aacgtttaga aactgtttat ttatataatt ttcgatactt agattatata
       61 atgaataata tcttagtgca agcacctaga ttattaaata aacacaaaaa atgtaagcgt
      121 tttattacct cttaccaaac taaaattcgg aaagaggttt ttattatgtc aattaaactt
      181 tacaacataa atgaggaata cagagaaaag ttttatcaaa taccgaaagt attttttaca
      241 aatcctaaat atatcaagtt atccaatgat gcaaaaatgg catggggtat tcttagagat
      301 cgtttagatt tatcaattaa aaatggttgg gttgattcta aaacaggtaa tatttatttt
      361 tattacaaaa atgaaaaccc acaaaatata ttaaattgta aaaaagataa agtaattaaa
      421 ataaagaaag aacttaattg aagccgaatt actactacaa gaaagacaag gtttaaataa
      481 gacaaataaa ctttatttag ttaaaccaga agtaacagaa gatgatattt ataaaattca
      541 aaagcaagaa aacactgttg agagcagcaa tggcaaggaa gtcggaaaaa ccgacttcaa
      601 gaagtcgata aaacagaatc taatgatact gaacttagct atactgaatc taacaatact
      661 gaaataaatg atatgaatga cttgaatgat atagagtccg aaaatgaaat tagtaatcat
      721 tcaagtcaat gcaaggttat ttaatgcaaa caattttaac tgaatttgaa gaaacacatg
      781 cactttatat gcgccgtaaa aacatgaaac aatataatat ctttaatcaa tcattcaaat
      841 gattttataa caatcaaaga tacatcaaaa tatttcgtta aatcatctga ctttttaact
      901 gatagcgatg aaaaaatcaa gaaattgtca gtggtctaga aaaagatttg tatcgaaaac
      961 gtatgttaag ttatggtgga ttgcttaaat aaaaacataa aattttaaac ttagacgatg
     1021 ctgaagatgg caatttaatt aatacaagtg atgaagataa aatagcaaat gaagaagaaa
     1081 aggcacattc gattacggca attttgaaaa gcaaaattat tatttaaggc attagtgata
     1141 actgatgtct ttttttatta cttttttgta aaaaaagtgc tgtcttattt ttgtgacaaa
     1201 tgctgtatgt agtgtcacaa aagtgtgaca cttgagcttt ttatgacccc acacaaaaac
     1261 attttcgaag ccttgaaata tctggctttg ccagatcccc cattcattga tggggacaaa
     1321 tttcccttat gctcttacgg agattttaga gttaaattaa aatttctaag tttttgataa
     1381 gaaaagccct gcaggaattt agaagaacgt ggggaagttt taaagaattt tatgctaatt
     1441 tttaatttgc atgtaaatgg gcagtgtcta aaaaatagtt attgtttttg ctcaaatttt
     1501 tgtttttgaa aatagcatat atttatttgg ctcatatttg cgttttaaaa gcgtatataa
     1561 gttttagata taaaactata tgaatcaccc ctaaatcttt aaaatgccct cttaaaattc
     1621 aaaataaggg cataaaaaat aaaagccccc ccagataaag tgaggtagct ttttctttcg
     1681 acgccgtatc gtcgatgtaa ttcaaaaaag ttatgggcta taaatctaca tcactttttc
     1741 aagaatgtag tagcaatatt caacgcaaat taatttttat aactgctcgg aatatctcaa
     1801 gccgtttctt taattttgaa ataaaaaaat cgacgaaggt cgattacgtt tttgcacatg
     1861 tcgatttatc cgacgtataa gtgcgccctt acgggattta actagattat aacgacgaat
     1921 tttagacctg taaagcaata acaattaggt ctaccaggta gataaagtgt acaaagtaga
     1981 accgaaaaag ttatttattt tgaagatttt tcgtagatat aatttgctaa taaacttcct
     2041 aaaactgaat aaagaaaaat agttaaactc atgtaatcac tccataattc tgaagtgtct
     2101 ccatgtctac gcatagacac gcatttatgc cgagaaaatt tattgtgcgt tgagaagaac
     2161 ccttaactaa acttgcagac gaatgtcggc atagcgtgag ctattaagcc gaccattcga
     2221 caagttttgg gattgttaag ggttccgagg ctcaacgtca ataaagcaat tggaataaag
     2281 cacctatgat tatttaaaaa tataagttat aatacattca aaaatatttt tgaatgaggt
     2341 gtattatgat tcaaacggtt gttgctgctg ctgttcttta tattgctaca gcagttgatt
     2401 tattagtaat tttattaata ttttttgcta gagcaaagac tagaaaagaa tatagaaata
     2461 tttatgttgg tcaatattta gggtctatta ttttaatatt agttagtttg tttttagctt
     2521 ttgtattaaa ttatgttcca gaaaagtgga tattaggttt attgggttta ataccaattt
     2581 atcttggaat taaagtggct atttatgatg attgtgaagg agaaaagaga gctaaaaaag
     2641 aattgaatga aaaaggattg tctaaattag ttggtacggt tgcaattgtt acgatagcaa
     2701 gttgtggcgc cgataatatt ggtttatttg ttccgtattt tgtgacatta agtgttacta
     2761 atttattact tactctgttt gtctttttaa ttttaatttt cttcttggtg tttactgcac
     2821 aaaaattagc taatatccca ggaattggag aaattgttga gaaatttagt cgttggatta
     2881 tggctatcat ttatatagct ttaggtttat ttattattat tgaaaatgac actattcaaa
     2941 caattttagg atttatattt taatttaggg tgtgatttta tatgagttat gaaaatactt
     3001 gtgatgtgat ctgtgtacat gaggataaag ttaacaatgc tttaagtttt ttagaagatg
     3061 ataaatctaa gaaattactt aacattttag aaaaaatttg tgatgagaag aaattgaaaa
     3121 tcatattatc tttgattaaa gaagatgagt tgtgtgtttg tgatatttct ttgatattga
     3181 aaatgagtgt tgcttcaact tcacatcatt taaggctttt atataaaaat gaggtacttg
     3241 atttttataa agatggaaag atggcatatt attttattaa agacgatgaa ataagagagt
     3301 ttttctctaa aaatcaggag ggtttttgaa acgagtgaaa cgagtttctt cttgtcttga
     3361 tactataaaa aacaaagtta tataacataa gacgacttat cggaagttat ctatcatcgt
     3421 atattcggag atgatataat atacaggtcg cctatctctc aggcgtcaat tcagacgcag
     3481 agaggaggtg cattactttg ctaatcattt tcgttcacat catagcacca gtcatcagtg
     3541 gctgtgctgt tgcgtattat acttattggc ttagtaaacg caacaaataa ttaataggcg
     3601 actttataag ccagcatcga aaaaatcccc acactattgc agtagtgtgg ggattggtgc
     3661 attaattgtt aatcattttc gttatctaga ttataacact ggttagtaga ggaatgcaaa
     3721 aagataatat tttaagtagt ctttttggat attatcatat gatatattta tgtaaattga
     3781 ttttttatta aaggagcata tatgagtaat actaaaatta aatatcaaat ttttatttca
     3841 tcaacttatt tagatttaat agaagagcgt caagcagtag tagaagcagt tttaaacagt
     3901 aataatattc cagcaggtat ggaacttttt aactcaagta gtaaaagcca atgggaaata
     3961 ataacacaat ggatcaatga atcagatgca gtgatattat tgttaggttc tagttatgga
     4021 acaattgata gtgaagaaaa tattagctat acagaaatgg agtacaattt tgctaaatct
     4081 ttaggtaaac ctatatatgt ttttgagatg aataaagcat ctaccgaatc cgcggaaaag
     4141 tctaaaaaat tagatgagtt taagacaaaa gttaaagaaa atagactaat tagtccaaat
     4201 attaatgata tttcggaatt aaaaagtaaa gtatctcaga ctttaatgca aagtgtacct
     4261 agtgaaatta aagaaaatag tggatggata agagtacagg attgtggtaa aaatgtaaaa
     4321 aaattaaaaa aattggatgc tatacaaaga gatttagata catatgattt tttgaaagaa
     4381 gaactttata aaatattcat gtatgtaaaa actttttatt tccagcacac accatttgat
     4441 gatagttata ttgaagatat agaaaactac ctgctaaatt atgaaaataa tccacataaa
     4501 tcattcatga aaataaaagt ttatgattat aaaaactttt taaaacattt aaaaaacata
     4561 ttgattttaa ttaaacaagg aaaaaagcca ttagctcaag ccggtcattt taaattaagc
     4621 ttttacgaag aggatttaaa attgttacaa aaaaattata agactacgct agtcgatatt
     4681 aaaggattga ataaacattt ttataaggaa tgtgataggt gcttaaaagc atataatatt
     4741 tttattgagg gtataaataa acatttatat gaatgatata agtacaccct aatcatacat
     4801 atataattgt tgtcacttta ctcgatatat gagaatgact ttacctaata aatgagaaaa
     4861 gcaacgcact atattaaaat gcgttgcttt ttctattatc gaatacctat aactaaacta
     4921 tctctagctg tttctacaac ttctgtactt attttatcta aaccatttat atccataatt
     4981 ctgtctatct gcgcaaataa acgatgaatc agcctaaaat tcccttttgt aattttaata
     5041 atcgtcgtta ttgcctcata atcagtaaag tcttcgagtt ttaaatcaaa tcctaagtct
     5101 tgccacttat attctaatat atgatgcgtc tcatctttac ttagattatc aaattcatgc
     5161 gcaaaaccta tacgcgaata tagttgagga taacgagata gttttttctc tatacccggc
     5221 ataccaataa atatcattgc taaattatgt tcatcataaa tagctcttaa ttgctctaaa
     5281 tgttgcactt taaggcgatc aatctcatct actataatta aatcaatata tttaaacata
     5341 tcactataat gtttactatg ttcatgtcca tacttattta caacatgtaa tttttgaccc
     5401 aaatcaatga ttgcagtaat actatataaa tcattcctta atttagtttg tttttctgct
     5461 ggtgcattat aaaatatttt atccaccgat agtatgtcat cggtcgtttt actagctaaa
     5521 tcttcccaac ctctatggtt aacttgtttt tcaatagtat cccaatttgt gtaataccta
     5581 gacgataaag tttttccgac accaggttga ccataacata taccaatata ctgatattta
     5641 atacaagcat cacaaaattc agcaaagcgt ttatactctt tcgtttcaat gaaattttga
     5701 tttttagtca ttacgatatc tctttaattt tttgacgttt ttagtcgttt cttgaggtga
     5761 ataaccacaa tttttttctt ccttaattaa ttccgtggta cttggactag caatattttg
     5821 ttttaagtgt tttcttctct gactacgagc gtgctgtatg tcttttatat ctatggagta
     5881 atcagctatt tctggacata tagcagtaca aagaaattca tctctataaa acacacgtat
     5941 ttcagccata tcatttgggt tataacgaat cagtacatat tcacctacat aagcttctag
     6001 attagtatta ctgtatcgaa aaccttgaaa atgaatgcca tctgaatgaa cttttctaga
     6061 tttaggtatt tccaacaata ataaatcaag ttgttctaag ctacttggca tattagggaa
     6121 aaagtgatta ctattccaat gactgatagg cgtggtatga atagtactat gttctttttg
     6181 attataatct tcaattaaaa agtaacgtaa tttttcttca aaattgtgaa aatttattag
     6241 attactagga gtatcattat tgtttatata tccaggcagt tgttctaaga aagtttgatt
     6301 aactgtctga aagaatcgtt ctatttttcc acgaccacga ggaacaccaa ctttcgaaaa
     6361 catcaagtta attttcaaat caatagcgac ttgttccata tgatgtgaag taaagtcact
     6421 tccatgatct gtgtagaatt tttcgggtat accacacact ggccaattgg tatcattttt
     6481 attccatatt gcttggtgta gtgttaatgc tgtgttttga gcattggggg gcatcaaaac
     6541 ttaagaaata gcctgcaatt gcacgactat agtcatccat aataatagtt agccatggtc
     6601 tattgatatt acctttttgg tctaatataa agatatctag caaagtatgg tctgcttgcc
     6661 atatttcatt gggtctcgag gattctctaa tttgtattaa atcgtactta ttttgatagt
     6721 atttttcacc ctgatgagag aaatcaataa cagacttagg catcgcttta ataacactat
     6781 aaatttgttt ataacttggt atatcaaaat tattttcttt acagtaatta gtgattttcc
     6841 tatgaattgt ggctatacta tttcttttat tcataagcgc aaggcgttca atttcatcaa
     6901 ttatctttgg ttctatttta cgtgttcctt tatcagctct tgtcgcatag attagtcctt
     6961 taagtccttg ttctttatat gacttattcc acctataaag ggtgcttaac gcaatccctt
     7021 tacttttaga aatacttgat aaagattgtt cgcctaggat aaaaggtttt ataatattgt
     7081 acttttgagt agctttttta cgtttggctt cagaaaaatt agttagatac ttctccttgt
     7141 ttttcatctt ccttgtcctc caatttattg aggtaacgat aaattgttgt acgtgaaaca
     7201 tgccactgtt ctgcaattgt cttaattggc gtgccattat cataaagggt cttaagtaag
     7261 tttaaatctt tttgatttaa tttttctggt ctgcctccat atcggcctct agcacgtgct
     7321 gcaattcggc cagctgaaga acgctctaaa attaaattac gttcaaattc tgcaaatgct
     7381 gcgaataaat gaaataataa ttgtccagtt gaacttgatt tatccattgt tatattttct
     7441 tctaaactat ggaaacttac acctcgttcg ttaagctcat taactaatgt gattaaatcc
     7501 tccatattac gtcccaatct atctaatctc caaacaacaa tcgtatctcc tgacctcgca
     7561 aattcaattg ctttatctaa accaggtctt ttactttttg aaccactcat atggtcatta
     7621 aatatctttt cacaaccata tgtatttaat cgatcctcct gtaaatttaa attttgtaat
     7681 ccagttgaaa ctcttgcata acctattttc aaaatacaaa cctcctatat acatcttcag
     7741 tgtaccataa cttaattaca aggtctttta tgaacataga ttttttgttg ggtttttgaa
     7801 cacataatcc tatgtaattc ttacttattt agacataaaa gaagagtgta cagaaaatgg
     7861 ttattttctg tacactctca tctttaataa tatattttaa atgtcattaa caaaactaat
     7921 ttaataagag tcaagcatag tttacatatg tattatgttt gaaacatacc tctaattact
     7981 ttttactaat atcatttaaa atatctcgca attcttcaat ttctttgtta tttaattctt
     8041 catttttcgc aaaattcaac actaaacttt tcatatcccc tccatacagt ttattaagaa
     8101 aggttttagc agttttcatt ttaatatcgt cttctttaat atttgatgag taaaaataaa
     8161 tattttctga tttgtatcgt tttataatct cttttttata tagtcttgtg attaatgttc
     8221 taatcgtttt atcactaact tctttatatt tttgaatttc aactacaatt tcattagctg
     8281 atactgattt tttatcccat attatattca taacatccca ttcagccata gatatttcaa
     8341 cttgcttatt ggccatttaa aacacccatt ccttttaata ttttttcact tattaattca
     8401 gcatttttcc cagacgggtt tccatctgat aaatgtgtag caaaataata cttatcatga
     8461 tttgtaatta cgtaacctac aaaccaccca ttattatact tcccgtttac tatacctgta
     8521 cctgttttcc catacagttc atacttttca tttttcttaa tcaataatga agaagataat
     8581 tgattctttg cttttttact aaaatggtta ttttgttcca tcatattttt aaaaactatt
     8641 acttgttcaa gattagatat tttcaaacta tcttccatcc aatagctttt ataacttccc
     8701 aaattttcat taccataatt taattgcttg agttgagccg cagtatagtt ctttggtatt
     8761 tgattactaa tacgttcgaa gtaccaatta actgaatttt gcattgctgt atttaaatct
     8821 tgttccttat tccaagactc gaaaagataa tgtttatgat tccatgacat acgtgaattt
     8881 ttatcactta taatatgacg gtcaagtcca aacagtgcta aataaatttt gtaagttgaa
     8941 tcaggagaat atctttttct actttctttt tcattataaa tatagtattt gtctttcttc
     9001 atgctgtaca taacgaaaga tccactattt gaaccaaaat ttttactttc atctaaaatt
     9061 tggtaatcgc tttgtaaggg ctttttataa ttataatcag ttaaggattg ccccattaaa
     9121 aactggcttt gaattatcat gataaaaaaa gtaaaaatac aaataaaaat tagaattaat
     9181 tttgactgct ttttcagatc ggcttctttt atattaatta atctattttt gagtaatgat
     9241 tttttaccat taaatgaatg gcttaatata tttttgttga aaaatgaggt ttttaatacg
     9301 gagtccataa tagattccgc ataagtttta aattcatttt tgttaatatt attaaggaca
     9361 aatctatcgg cttctacttc attgtcatga attatctttc tttttacaat atgtactaat
     9421 ggattgtaac tcataataat agagaagata ttaaagataa ttaaatgtaa agtatctcta
     9481 tttttagcat gagcatattc atgcagtatt atatatttta gtcttttatc aattacactt
     9541 ttaaaatatg aactaggaat caaaataata tatttcccat accaaaaagt tattggagat
     9601 tgaatagcct ctgcttttcg aatcacaata ttttttttat attgatggtt gaaaagtatc
     9661 gtatctattt tatttttttc attttcgttt agataaagtg actgtttctt taaatattta
     9721 agatataata aggctttcaa aaatttaaaa cttaaaataa taactaaaac tatccaaata
     9781 actgtgcaga tattatcaat tgaatcccaa ttaaacttat ggatatctgt tgcgaactct
     9841 tgaacaggtt tggtggtaat tatgttatgg ttcaagtcgt gtgacttact ttcaactgtg
     9901 ggcgcttgat tattcacatt attaaatttt ataaaagaga atttaattgg gataaaagga
     9961 attaatccag caagcacagt tagataccaa actttataat ttaaactata attaaaatag
    10021 cgttttaata tgtacctaaa aaatactaac aatagaaata taaaacaaaa gcttactaca
    10081 ctcattatta gtaatttagc cattttgaca ccttctttca aatatttata ataaacaatt
    10141 gacatcaata ttacaattgt aatattattg ttttgtaaaa attacaactg taatatcgga
    10201 gggtttattt tgaaaaagtt aatattttta attgtaatgg ctttagtttt aagtgcatgt
    10261 aattcaaaca gttcacatgc caaagagtta aatgatttag aaaaaaaata taatgctcat
    10321 attggtgttt atgctttaga tactaaaagt ggtaaggaag taaaatttaa ttcagataag
    10381 agatttgcct atgcttcgac ttcaaaagcg ataaatagtg ctattttgtt agaacaagta
    10441 ccttataata agttaaataa aaaagtacat attaacaaag atgatatagt tgcttattct
    10501 cctattttag aaaaatatgt aggaaaagac atcactttaa aagaacttat tgaggcttca
    10561 atgacatata gtgataatac agcaaacaat aaaattataa aagaaatcgg tggaatcaaa
    10621 aaagttaaac aacgtctaaa agaactagga gataaagtaa caaatccagt tagatatgag
    10681 atagaattaa attactattc gccaaagagc aaaaaagata cttcaacgcc tgctgctttc
    10741 ggcaagactt taaataaact tatcgcaaat ggaaaattaa gcaaaaaaaa taaaaatttc
    10801 ttacttgatt taatgtttaa taataaaaac ggagacactt taattaaaga tggtgttcca
    10861 aaagactata aggttgctga taaaagtggt caagcaataa catatgcttc tagaaatgat
    10921 gttgcttttg tttatcctaa gggccaatct gaacctattg ttttagtcat ttttacgaat
    10981 aaagacaata aaagtgataa gccaaatgat aagttgataa gtgaaaccgc caagagtgta
    11041 atgaaggaat tttaatattc taaatgcata ataaatactg ataacatctt atagtttgta
    11101 ttatattttc tattatcgtt gacatgtata attttgatat caaaacctga ttttcccttt
    11161 attattttcg agatttattt tcttaattct ctttaacaaa ctagaaatat tgtatataca
    11221 aaaaatcata aataatagat gaatagttta attataggtg ttcatcaatc gaaaaagcaa
    11281 cgtatcttat ttaaagtgcg ttgctttttt tctcatttat aaggttaaat aattctcata
    11341 tatcaagcaa agtgacataa ttgttgaatt tatagtaact gaaacgtatg attagggtgt
    11401 atattaatta tgagatggaa atcaatgatt gttggctatg cgagagtatc atcgaacgat
    11461 caaaatttag aaagacaact tgaaaattta aagacgtttt gtgctgaaaa aatatttaca
    11521 gaaaaacagt ctgggaaatc tattgaaaat agaccagtac ttcaagaagc acttaacttt
    11581 ttgaggatgg gagatcggtt tgtagtagaa tccattgatt gtttaggtcg taattatgat
    11641 gaagtgattc ataccgttaa ttatttaaaa gacaaagaag tacaattaat gattactagc
    11701 ttacctatga tgaatgaagt ggttggcaat ccattactgg ataagtttat gaaagattta
    11761 attattcaaa tattagcaat ggtttcagaa caagagagaa atgaaagtaa acgtcgacaa
    11821 gcgcaaggaa ttcaagttgc gaaggaaaaa ggcatatata aagggcgccc cttactttat
    11881 tcaccaaatg ctaaagatcc acagaaacgt attatttatc atcgcgttgt agaaatgtta
    11941 gaagaaggcc aatcaattag taaaattgcg aaagaagtaa atataacaag gcagacgatt
    12001 tacagaatta aaaacgataa tgatttgatt taataaactt tgtttcaatg caactgagag
    12061 cttctcacag cgtctcaaaa cagatgatta taatctatta tgagttttta ataataagac
    12121 aagaaaagag agcgtaaata tgctctctct ttttctcatt aacgaatgtt tataacgcaa
    12181 tcatgatgag agtattaata cagttaatta tttgaaatac tttagtttat ataatgttga
    12241 attataggta gtgaaattgt atttattata cattgtcata tcgttgttta atgatagtta
    12301 atttaaggat aatagaatta atattatata tagatgaaca aaacaagcaa cagagcagaa
    12361 aaaacacttt tagattattt ttactcatcc tctattttat ttatttttgc tataataaat
    12421 aaagaatatt aaatggaggt gtttttatga aaaagaaatt tgtttctagt tgtattgcta
    12481 gtacaatctt attcggcact ttattaggtg taacttataa agctgaagct gcaacagtac
    12541 atgtagctgg tggtgtttgg agccatggta ttggaaaaca ttacgtatgg tcttattata
    12601 gtcacaataa aagaaatcat ggttcaacag cagtagggaa atattcatct tttagtggtg
    12661 ttgctcgacc tggtgttcaa tctaaggcat ctgctccaaa ggcttggggt ggaaacaaaa
    12721 cattttatag tcttcactaa ttacatatat taattaagga gaatagacag aattaagtaa
    12781 acttaattct gtctattctc ttgaaagagg caatatgaaa aaattcaaat tatttttaga
    12841 ttttagtact ttattattaa tttcagggct attattttta tttttcttca aagaaaatga
    12901 agaaattata cctgaaagtt ccaatatttt aacaatctct aattgggata aatctaacag
    12961 taaatcaaaa gtgttagatg tcattgaatc aggcgccaaa aatcaaaata tacaaataat
    13021 taaatccgtt aaagattttg ataataaaaa agaatttttt gttttcaact caaaacgaaa
    13081 taattctgac tttatacgta ataaaacatc acttttaact ccatcagatt tattaaacag
    13141 agagataaaa ggaaagtatt atattattgg tgaacatttc aatgtagaag agcttacgag
    13201 tgaattaaaa aaagctggtt taacatctga agttgaatac ataaatagaa acatattatt
    13261 ttttgaatta gtcatagata atgatttatt agtgcctttc atattcttag gcgtattata
    13321 tcttttgtac ttcttatatg acagaggata taatttgaaa ttttatgcta ttcaaaagct
    13381 acatggcttt tcaactacac gcattatttt tcataatatt catataaaaa tcatttattg
    13441 gctagtactt accgctattt tctttattgc taatatatta atcattcata tagccaattt
    13501 agaattggat ttcttaatgt ttattcgtag atttatcgtg ttgctttttg tttttgcttg
    13561 tattactaca ttgctgtggc tgatttcgta tagtcttctt ttgaagttaa gtattccatt
    13621 aatcttaaaa gggaaaaaag gatataagtt ttcaatattt atgggtacct tcaccaaatg
    13681 tatcatggtg ctaatactat cttttttact ggcacaaaat ttaaatgctt atacgaagtt
    13741 aaagaatata tatgactctg aaaaaatctg gcaaaagtta gataattact atacattaga
    13801 gatttctcct aatattagaa attcagaaga aaaacaaatt ttagaaacta atatatacaa
    13861 tttaattaag aaaagcgaac aacttggtgg attgctttta aagaataata atatagccaa
    13921 tcccgataaa aacaattaca ttcctgaaaa tggcaatgtc ttttttatca ataacaattt
    13981 tctgaatttc tataaaaata taaatcatga ttttaaaatg attgacaatc attcggataa
    14041 aataaacgtg tttattcctc caaggttaca atatcaaaaa tctgaaattc aaaaaaatca
    14101 ccaaggatgg attgactttc aaaagcaaca aaacaaaaaa gtagatgtgc aagtactgtc
    14161 aaaaaacgta tctgtttttt cttttgatcg cacaactaat ttgaaatttg ggtatctaga
    14221 ttctccaata gtaatgttgt tgacacttga cgatttaaca ggagattttt atttagctgc
    14281 tgtttctcaa ggtggatatc tatttaaaga tttagataca cttaaacagt tgcttaaaga
    14341 taatcaccta gaagaagaaa ttagcggtat aactaattac aaggattctg tgttaaatga
    14401 attaaatgaa acgaaaacaa aaatgataat aacaatagtt actattatta ttaacgtttt
    14461 cattcttttg atagctactg tatttgaaac aattcaatat tttagctgga ataaaaagca
    14521 actattatta agaaaaattc atggttattc attattcagc agtaatgtac gttatttaac
    14581 aatttctatc ttactttcta ttatgttagc ttacactacg catattttat ttggttcaaa
    14641 gatattacta ttcataataa tgtctattgc tattattcaa catttacttc aaattgctta
    14701 tattaaatat cttgaaaaat actttaaaga tttaatgagg gagatttaaa caatgaaaag
    14761 aactttaatt attgtaacaa ttgtactatt aatcatcata cttagtctgt tattggttag
    14821 aaatgagcat ttagatcgtt ttaacccact gttaaaagaa aaagtatctt atgccaaagt
    14881 tccaaaagat acccaggact atagaaatat aactgtatac tctaaaaatg gagaaaaaaa
    14941 gagttataaa ttggattttt taggttatga tcctacaaaa gaatatgtga aagtaaatca
    15001 taaagggaaa tatgtgcgtt cgatagaata cattacaaaa gatattccta gctttttaaa
    15061 atgaggtgac cgatagtgat aaaacttgaa aatgtttttg taaaaaaagg taataaaaac
    15121 attttagacg gatgtaactt taattttgaa aaaggaaaat catatgcttt agttggagaa
    15181 agtggcgctg gaaaatctac tttacttaac ataatcgctg ggttcgaaga tgtatcacaa
    15241 ggaagcatat atattgaaga taagttacta aaaaagaaag tcgattttta tagatatacg
    15301 ttagggtatt tgtttcaaaa ttttgcttta cttgaaaatc aaacaatcag tcaaaattta
    15361 gatttagccc taaagttcaa aaagaataaa aaagataata tgaacttaaa gaaagaagta
    15421 ttaaaaaagg tcggcctaga tttagatatc aagagaattg ttagttctct aagcggtggt
    15481 gaacaacaaa gagtagcatt ggcaagatta atattaaaag atccgaaaat cattttagct
    15541 gatgaaccta ctgggtcact agatacgaaa aatggaaaaa tagttattga tttattattg
    15601 aagctacttg atgaaaataa aactatgatt gtcgtaacgc atgatttaga gcttgcgaaa
    15661 cgatttgatg tcatagtcaa tatttctgag cttagaagtt aagaaatatt gataggtata
    15721 gccatacata gagaaaaaac aatatgaaat atgattagtc attacttttg agttttttaa
    15781 tttaaggact ggattttcca gtcctttttt atgatgacaa aaaacaagcc tcgcagagca
    15841 cacgttttta atgacttatt tggtttttaa taagtctagt atgttaaaac ttttctgtgt
    15901 ttaggtgtta taatcatatg cagtggaagt tgatttatta tgtcttattc aattattcga
    15961 gttgttaaag tgaaatcaaa aacaaataca agaggtattc aaagacatat tcaaagagaa
    16021 aataaaaatt atgaaaatat agatattgat ttaagtaagt catatttaaa ctatgattta
    16081 gtcaatgata ctaagtttga ttttaataaa aaaattgatg agaaaatcga aaaaaattat
    16141 aaagggaaac gcaaaattag aacagatgcc attaaacata ttgatggatt aattacatca
    16201 gataatgtgt tttttaatca attatctgaa gaagagacaa aatagttttt taagcatgct
    16261 aaagcgttct tggaagaaga atacggtaaa gaaaatcttt tatatgcgac agtacatatg
    16321 gatgagataa caccacatat gcattatggc gtagttccta ttactaaaga tggacgttta
    16381 agtgcgaaag aagttgtagg taataaaaaa gcattaaccg aattccaaga tagattcaat
    16441 acgtatatta ataagcaagg ctatgattta aaacgaggaa tttctagaca acttacaaaa
    16501 gaaaaacatg atcaagttag ccgttataaa caaaaaacag aatatcataa acaaatgcat
    16561 atgcgctaga agcaaataga ggattattta aagcaagaaa atgataaatt gatacaaaac
    16621 taccaaaaat cattagatgc gcttaaaaag cttctgagtg tcatgtatga aattaaaact
    16681 aaaaatgtag gtggatggtt tcataaagag aagcaagaaa caggcaatat tgtaattact
    16741 aaaactgatt ttgaaaaata cactaaacaa attaaagcag cacagatgat attagatgat
    16801 tatgaatgta ttaaaagtgg gaagtcatta aaaaaagcag agaaacaaaa tgaaagttta
    16861 gttaatgaat tgactagtgt ccatatggaa aatgaaaagc tggttgaaga atttaatgat
    16921 ttagcacaac gttataatta tttgttgtca gagaatgaaa agaaagataa agaactaaat
    16981 tatacgctta agttattcaa tcaagttttt aaaatcatta aaagtatgat gaaagaagag
    17041 cgttatcata cactaataaa tcatattgat aatcatttag acaattctaa aatacgtgaa
    17101 gtaatgacga tagataacaa tgatgaacag ttctttaaga agaaatatca agcacaagaa
    17161 cgagaaatca tttttaaaga agatagagaa gatggttata cattataaaa atagatattt
    17221 aaatgcattt gtttgaggtt aattattttt taggatgaaa aataggtagc ccccctcgaa
    17281 ctttttaata tatttttata aatcttttta aaaacctttt taggggcttt ttcagcccta
    17341 gagcaacaag ggatttcaat gcctaaagga gtgtttttgc cacataaaag gagtgttttt
    17401 gccacataaa aggagtgttt ttgccacata aaaggagtgt ttttgccaca taaaaggagt
    17461 gttttaaaaa gttgtactcc ttttatggtt tgacattgat aataaagtag tttattgtga
    17521 ataaaagttt tcaaatggga gtgtatattc aaacgatact cctttaggtt cgtaataaag
    17581 ggggctgtat catgacagga gagacagttg tatataaaaa tgaaatgaat ttagttccat
    17641 taaggcgatt tacagctact gaaattaatt tattttttgc gatgtgtaat aaattaaaag
    17701 agcaagatac taatacatta cgtttgtctt ttgatgaatt aaaaaaatta agtaattata
    17761 gtccagaaac acgtaatatt aatagatttg ctaatgattt agataatgtg tataaaaaga
    17821 tgttgaattt aaccattaga tatgaagatg atgatgtaat agaaagattc gttttattca
    17881 atcattatag aatccataag cgagaacaat atctagaaat atcaacttct tcaaatttaa
    17941 aacacatatt gaattcaatt actaataatt ttacaaaatt tgaattaaaa gaaatgacta
    18001 ggcttaaatc tacatattct aaaaatatgt ttagattact taaacaatac aaacatacag
    18061 gctatttaaa aattcacatc gatgatttta aaaatcgttt agatatacct aaatcttatc
    18121 gtatgactga tattaacaaa aatgttttta aacctattat tattgaatta ggttctatat
    18181 ttaataatct tactatcaat aaaatcaaag cgaaaaaagg gcgtaaaatt gaatggatag
    18241 agttcacatt tgacgctgag aaacgcattc ataacaaacg acaacctcaa atgtccaaga
    18301 tagataaatc aagacaatat gtgaggcgtg aaaagacgcc taaatggtta gaagaacggt
    18361 catatgaaaa gcaacctcaa aaagattacg acccacaatt agagaaagaa cgagaggatt
    18421 ttttaaaaca acttgaactg aattgggaat aacgcaactt ttcgttgcga gttggttaac
    18481 taaaagtatc gtgacttttc aattatttta attatagttt gagttaagga gtgattttat
    18541 gaaattagct gaagctataa aagaacagag agaattaaaa ggatggtctc aagaggaatt
    18601 agccaatata ttaaaggttt ccagacaaag tgtttctaaa tgggaaagtg ccaaaaacta
    18661 tccttcctta gatattttga ttgctatgag cgatttattc ggaatctctt tagagcattt
    18721 aattaaagga gatgcacgtt ttaaaaaagt tattttagag ggaaattata gagagagtaa
    18781 cagggtacct tccatagttg attttcttta tgatttttgg tggcttttct ttcctgttgc
    18841 cggattttta gtttgggcca ttcattcgtt catgggttga ttttaaaatc aaaatttaat
    18901 gcacatcagg caatatgaaa aaggaaagta tttttacgac accttgaaat gtattgataa
    18961 gaatagaaga gtttacaaaa ggcaatatga aatatatact aaaagtaaca agaatttcgt
    19021 ttgtaaacgc acaaaacccc gaactattcg ccgtagttcg gggttttgtg gtgaattggc
    19081 tttaatcgtc tatattattt tttatcacgt ttatggagct aataaccaaa taacgtaacg
    19141 agacaaccac tgattgccgt tgtcatgatg tgaacaagaa tttcattcat aaatcgcacc
    19201 tcctctctac gccgaattga catctgagag atagacgacc ttcacattat aacaaatctc
    19261 tccttccatg aaataacatg aatattaata aatgttgtta tatattaaag ataaataaat
    19321 ataagggtgg gattgataat gtttggcgat caaagacaag aagctacaaa atatgtcatt
    19381 aaagaaggtt atcaagatat ttatttcctc aacaaaaacg gggaatggta ttatttcgaa
    19441 gtaagaagtg tctggcgtgg caaacatatt attagagtta aagatggttt gttaggttgg
    19501 agaaaagaaa tagtaactga ataaagatac aaaatacttg ccaatgcaaa agaatgaaaa
    19561 cgcgtcaaat caacgatgta taaaagatgc ataaaagata atgaaagtaa aaagccataa
    19621 atgccgtcat ataggcattt atggcttttt gtttggttaa cataatcgat gattatcaga
    19681 agttcaattc acataaaaaa gcacggctaa tttatgaact tgtcgtacct ttttaattaa
    19741 aattagttac caaatagacg actccaaaac ccctttttag gttccgtttc ttcactcttt
    19801 tcttctatat cactatcatt gtcatttgga ttagctgaaa cgtcttctct ttgtgcttct
    19861 tcaccttgtg tactttcgtc gctttgactt ccagatatat ccttatattg aatctctgtt
    19921 tctttagttt cttcctgatc tcggttaata tttacaggac tagtagtata tgttttttct
    19981 tgtgcatcaa cgttttgtct agcgttagta gatgtatcaa agggataatt aaggtgtttt
    20041 tctttttcta attgattttc taatttttga atctttttat tactctctaa tgccagaact
    20101 tgctgattct caagcaattt tgatctttct tgcaactctt ttctgtaaaa ttcaattgtt
    20161 gtttcatgac gactttcttg tttttcaatt tgattattta aagtattaat ctgattttta
    20221 agtatttcta ctatttgagc atcgctttta gattcaaaat taatattatc cgactctttt
    20281 ttttgtttgt cttcagtagc actttcaaaa ccatatttct ttttattttc atttactctt
    20341 tgaatgattt tttctatatc ggtatcttct ttaataaacg aagtgttttc ctgttttatt
    20401 gtctctatat tcaatctctt aatattatta aaaatcgttt gcttactaac ccctaattct
    20461 tcactcaacc tttttacact tttcatatca tcaacccttt ataaaatgtt tataaaccct
    20521 tagtaaaata ttataagctt ataacgatta ataataaagt aatcgacaaa taaaaatata
    20581 aattcgccaa cctttttatc aagggtttgt aaagggttta tggtgtttat caaaggttta
    20641 taaacctata ttttcccttt tttaagttta ttcaaagtgc tataataacc ttaatataac
    20701 aaaaacccca actactggta atagtcgggg t
//
