LOCUS       NZ_CP047812            20730 bp    DNA     circular CON 18-DEC-2023
DEFINITION  Staphylococcus aureus strain UP_1522 plasmid unnamed, complete
            sequence.
ACCESSION   NZ_CP047812
VERSION     NZ_CP047812.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN11175638
            Assembly: GCF_009911815.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 20730)
  AUTHORS   Dilthey,A., Meyer,S. and Kaasch,A.
  TITLE     Increasing the efficiency of long-read sequencing for hybrid
            assembly with k-mer-based multiplexing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 20730)
  AUTHORS   Dilthey,A., Meyer,S. and Kaasch,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JAN-2020) Institute for Medical Microbiology and
            Hospital Hygene, University Hospital Duesseldorf, Moorenstrasse 5,
            Duesseldorf 40225, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: Unicycler Hybrid Assembly v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 43x / 446x
            Sequencing Technology :: Illumina MiSeq / Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 12/17/2023 04:34:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,774
            CDSs (total)                      :: 2,692
            Genes (coding)                    :: 2,617
            CDSs (with protein)               :: 2,617
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 75
            CDSs (without protein)            :: 75
            Pseudo Genes (ambiguous residues) :: 0 of 75
            Pseudo Genes (frameshifted)       :: 44 of 75
            Pseudo Genes (incomplete)         :: 25 of 75
            Pseudo Genes (internal stop)      :: 17 of 75
            Pseudo Genes (multiple problems)  :: 10 of 75
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047812.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..20730
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="UP_1522"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="unnamed"
     gene            166..842
                     /locus_tag="E3T10_RS13875"
                     /pseudo=""
     CDS             166..842
                     /locus_tag="E3T10_RS13875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /name="replication initiator protein A"
     gene            <853..1135
                     /locus_tag="E3T10_RS13990"
                     /old_locus_tag="E3T10_13720"
                     /pseudo=""
     CDS             <853..1135
                     /locus_tag="E3T10_RS13990"
                     /old_locus_tag="E3T10_13720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199895.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            2346..2963
                     /gene="cadD"
                     /locus_tag="E3T10_RS13725"
                     /old_locus_tag="E3T10_13725"
     ARG             2347..2960
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="99.51"
                     /coverage="100.0"
     gene            2982..3329
                     /locus_tag="E3T10_RS13730"
                     /old_locus_tag="E3T10_13730"
     CDS             2982..3329
                     /locus_tag="E3T10_RS13730"
                     /old_locus_tag="E3T10_13730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000119691.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNQEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            3498..3590
                     /locus_tag="E3T10_RS13735"
                     /old_locus_tag="E3T10_13735"
     CDS             3498..3590
                     /locus_tag="E3T10_RS13735"
                     /old_locus_tag="E3T10_13735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001791613.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            3802..4776
                     /locus_tag="E3T10_RS13740"
                     /old_locus_tag="E3T10_13740"
     CDS             3802..4776
                     /locus_tag="E3T10_RS13740"
                     /old_locus_tag="E3T10_13740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4062 domain-containing protein"
                     /protein_id="WP_000072391.1"
                     /translation="MSNTKIKYQIFISSTYLDLIEERQAVVEAVLNSNNIPAGMELFNS
                     SSKSQWEIITQWINESDAVILLLGSSYGTIDSEENISYTEMEYNFAKSLGKPIYVFEMN
                     KASTESAEKSKKLDEFKTKVKENRLISPNINDISELKSKVSQTLMQSVPSEIKENSGWI
                     RVQDCGKNVKKLKKLDAIQRDLDTYDFLKEELYKIFMYVKTFYFQHTPFDDSYIEDIEN
                     YLLNYENNPHKSFMKIKVYDYKNFLKHLKNILILIKQGKKPLAQAGHFKLSFYEEDLKL
                     LQKNYKTTLVDIKGLNKHFYKECDRCLKAYNIFIEGINKHLYE"
                     /name="DUF4062 domain-containing protein"
     gene            complement(4896..5711)
                     /locus_tag="E3T10_RS13745"
                     /old_locus_tag="E3T10_13745"
     CDS             complement(4896..5711)
                     /locus_tag="E3T10_RS13745"
                     /old_locus_tag="E3T10_13745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019467708.1"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WP_000164958.1"
                     /translation="MTKNQNFIETKEYKRFAEFCDACIKYQYIGICYGQPGVGKTLSSR
                     YYTNWDTIEKQVNHRGWEDLASKTTDDILSVDKIFYNAPAEKQTKLRNDLYSITAIIDL
                     GQKLHVVNKYGHEHSKHYSDMFKYIDLIIVDEIDRLKVQHLEQLRAIYDEHNLAMIFIG
                     MPGIEKKLSRYPQLYSRIGFAHEFDNLSKDETHHILEYKWQDLGFDLKLEDFTDYEAIT
                     TIIKITKGNFRLIHRLFAQIDRIMDINGLDKISTEVVETARDSLVIGIR"
                     /name="AAA family ATPase"
     gene            complement(5704..7147)
                     /locus_tag="E3T10_RS13750"
                     /old_locus_tag="E3T10_13750"
                     /pseudo=""
     CDS             complement(5704..7147)
                     /locus_tag="E3T10_RS13750"
                     /old_locus_tag="E3T10_13750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790716.1"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DDE-type integrase/transposase/recombinase"
                     /name="DDE-type integrase/transposase/recombinase"
     gene            complement(7119..7712)
                     /locus_tag="E3T10_RS13755"
                     /old_locus_tag="E3T10_13755"
     CDS             complement(7119..7712)
                     /locus_tag="E3T10_RS13755"
                     /old_locus_tag="E3T10_13755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690636.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690638.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNQKDLNLLKTLYDNGTPI
                     KTIAEQWHVSRTTIYRYLNKLEDKEDEKQGEVSN"
                     /name="recombinase family protein"
     gene            complement(7976..8356)
                     /gene="blaI"
                     /locus_tag="E3T10_RS13760"
                     /old_locus_tag="E3T10_13760"
     ARG             complement(7980..8356)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            complement(8346..10103)
                     /gene="blaR1"
                     /locus_tag="E3T10_RS13765"
                     /old_locus_tag="E3T10_13765"
     ARG             complement(8350..10103)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.56"
                     /coverage="100.0"
     gene            10210..11055
                     /gene="blaZ"
                     /locus_tag="E3T10_RS13770"
                     /old_locus_tag="E3T10_13770"
     ARG             10211..11052
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            11424..12032
                     /locus_tag="E3T10_RS13775"
                     /old_locus_tag="E3T10_13775"
     CDS             11424..12032
                     /locus_tag="E3T10_RS13775"
                     /old_locus_tag="E3T10_13775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002436987.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001566953.1"
                     /translation="MIVGYARVSSNDQNLERQLENLKTFCAEKIFTEKQSGKSIENRPV
                     LQEALNFLRMGDRFVVESIDCLGRNYDEVIHTVNYLKDKEVQLMITSLPMMNEVVGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRI
                     IYHRVVEMLEEGQSISKIAKEVNITRQTIYRIKNDNDLI"
                     /name="recombinase family protein"
     gene            12446..12739
                     /locus_tag="E3T10_RS13780"
                     /old_locus_tag="E3T10_13780"
     CDS             12446..12739
                     /locus_tag="E3T10_RS13780"
                     /old_locus_tag="E3T10_13780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_000726502.1"
                     /translation="MKKKFVSSCIASTILFGTLLGVTYKAEAATVHVAGGVWSHGIGKH
                     YVWSYYSHNKRNHGSTAVGKYSSFSGVARPGVQSKASAPKAWGGNKTFYSLH"
                     /name="lactococcin 972 family bacteriocin"
     gene            12814..14748
                     /locus_tag="E3T10_RS13785"
                     /old_locus_tag="E3T10_13785"
     CDS             12814..14748
                     /locus_tag="E3T10_RS13785"
                     /old_locus_tag="E3T10_13785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001670421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="WP_000713729.1"
                     /translation="MKKFKLFLDFSTLLLISGLLFLFFFKENEEIIPESSNILTISNWD
                     KSNSKSKVLDVIESGAKNQNIQIIKSVKDFDNKKEFFVFNSKRNNSDFIRNKTSLLTPS
                     DLLNREIKGKYYIIGEHFNVEELTSELKKAGLTSEVEYINRNILFFELVIDNDLLVPFI
                     FLGVLYLLYFLYDRGYNLKFYAIQKLHGFSTTRIIFHNIHIKIIYWLVLTAIFFIANIL
                     IIHIANLELDFLMFIRRFIVLLFVFACITTLLWLISYSLLLKLSIPLILKGKKGYKFSI
                     FMGTFTKCIMVLILSFLLAQNLNAYTKLKNIYDSEKIWQKLDNYYTLEISPNIRNSEEK
                     QILETNIYNLIKKSEQLGGLLLKNNNIANPDKNNYIPENGNVFFINNNFLNFYKNINHD
                     FKMIDNHSDKINVFIPPRLQYQKSEIQKNHQGWIDFQKQQNKKVDVQVLSKNVSVFSFD
                     RTTNLKFGYLDSPIVMLLTLDDLTGDFYLAAVSQGGYLFKDLDTLKQLLKDNHLEEEIS
                     GITNYKDSVLNELNETKTKMIITIVTIIINVFILLIATVFETIQYFSWNKKQLLLRKIH
                     GYSLFSSNVRYLTISILLSIMLAYTTHILFGSKILLFIIMSIAIIQHLLQIAYIKYLEK
                     YFKDLMREI"
                     /name="bacteriocin-associated integral membrane family
                     protein"
     gene            14752..15063
                     /locus_tag="E3T10_RS13790"
                     /old_locus_tag="E3T10_13790"
     CDS             14752..15063
                     /locus_tag="E3T10_RS13790"
                     /old_locus_tag="E3T10_13790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YxeA family protein"
                     /protein_id="WP_160186344.1"
                     /translation="MKRTLIIVTIVLLIIILSLLLVRNEHLDRFNPLLKEKVSYAKVPK
                     DTQDYRNITVYSKNGEKKSYKLDFLGYDPKKEYVKVNHKGKYVRSIEYITKDIPSFLK"
                     /name="YxeA family protein"
     gene            15075..15701
                     /locus_tag="E3T10_RS13795"
                     /old_locus_tag="E3T10_13795"
     CDS             15075..15701
                     /locus_tag="E3T10_RS13795"
                     /old_locus_tag="E3T10_13795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000593103.1"
                     /translation="MIKLENVFVKKGNKNILDGCNFNFEKGKSYALVGESGAGKSTLLN
                     IIAGFEDVSQGSIYIEDKLLKKKVDFYRYTLGYLFQNFALLENQTISQNLDLALKFKKN
                     KKDNMNLKKEVLKKVGLDLDIKRIVSSLSGGEQQRVALARLILKDPKIILADEPTGSLD
                     TKNGKIVIDLLLKLLDENKTMIVVTHDLELAKRFDVIVNISELRS"
                     /name="ABC transporter ATP-binding protein"
     gene            15939..16568
                     /gene="mobV"
                     /locus_tag="E3T10_RS13995"
                     /pseudo=""
     CDS             15939..16568
                     /gene="mobV"
                     /locus_tag="E3T10_RS13995"
                     /inference="COORDINATES: protein motif:HMM:NF013258.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MobV family relaxase"
                     /name="mobV"
     gene            16662..17207
                     /locus_tag="E3T10_RS13810"
                     /old_locus_tag="E3T10_13810"
     CDS             16662..17207
                     /locus_tag="E3T10_RS13810"
                     /old_locus_tag="E3T10_13810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001805533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000273005.1"
                     /translation="MYEIKTKNVGGWFHKEKQETGNIVITKTDFEKYTKQIKAAQMILD
                     DYECIKSGKSLKKAEKQNESLVNELTSVHMENEKLVEEFNDLAQRYNYLLSENEKKDKE
                     LNYTLKLFNQVFKIIKSMMKEERYHTLINHIDNHLDNSKIREVMTIDNNDEQFFKKKYQ
                     AQEREIIFKEDREDGYTL"
                     /name="hypothetical protein"
     gene            17591..18451
                     /locus_tag="E3T10_RS13820"
                     /old_locus_tag="E3T10_13820"
     CDS             17591..18451
                     /locus_tag="E3T10_RS13820"
                     /old_locus_tag="E3T10_13820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_000145511.1"
                     /translation="MTGETVVYKNEMNLVPLRRFTATEINLFFAMCNKLKEQDTNTLRL
                     SFDELKKLSNYSPETRNINRFANDLDNVYKKMLNLTIRYEDDDVIERFVLFNHYRIHKR
                     EQYLEISTSSNLKHILNSITNNFTKFELKEMTRLKSTYSKNMFRLLKQYKHTGYLKIHI
                     DDFKNRLDIPKSYRMTDINKNVFKPIIIELGSIFNNLTINKIKAKKGRKIEWIEFTFDA
                     EKRIHNKRQPQMSKIDKSRQYVRREKTPKWLEERSYEKQPQKDYDPQLEKEREDFLKQL
                     ELNWE"
                     /name="replication initiation protein"
     gene            18538..18879
                     /locus_tag="E3T10_RS13825"
                     /old_locus_tag="E3T10_13825"
     CDS             18538..18879
                     /locus_tag="E3T10_RS13825"
                     /old_locus_tag="E3T10_13825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761340.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000761341.1"
                     /translation="MKLAEAIKEQRELKGWSQEELANILKVSRQSVSKWESAKNYPSLD
                     ILIAMSDLFGISLEHLIKGDARFKKVILEGNYRESNRVPSIVDFLYDFWWLFFPVAGFL
                     VWAIHSFMG"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(19118..19189)
                     /locus_tag="E3T10_RS13830"
                     /old_locus_tag="E3T10_13830"
     CDS             complement(19118..19189)
                     /locus_tag="E3T10_RS13830"
                     /old_locus_tag="E3T10_13830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_106873653.1"
                     /translation="MNEILVHIMTTAISGCLVTLFGY"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            19338..19523
                     /locus_tag="E3T10_RS13835"
                     /old_locus_tag="E3T10_13835"
     CDS             19338..19523
                     /locus_tag="E3T10_RS13835"
                     /old_locus_tag="E3T10_13835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000466619.1"
                     /translation="MFGDQRQEATKYVIKEGYQDIYFLNKNGEWYYFEVRSVWRGKHII
                     RVKDGLLGWRKEIVTE"
                     /name="hypothetical protein"
     gene            complement(19742..20485)
                     /locus_tag="E3T10_RS13840"
                     /old_locus_tag="E3T10_13840"
     CDS             complement(19742..20485)
                     /locus_tag="E3T10_RS13840"
                     /old_locus_tag="E3T10_13840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_000843758.1"
                     /translation="MKSVKRLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESATEDKQKKESDNINFESKSDAQIVEILKNQINTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNAR
                     QNVDAQEKTYTTSPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAQREDVSANPND
                     NDSDIEEKSEETEPKKGFWSRLFGN"
                     /name="DUF536 domain-containing protein"
     ARG             10211..11055
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     BGC             7446..17739
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          1193..1340
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="81.333"
                     /coverage="100.0"
                     /evalue="2.96e-25"
     Typing          17592..18451
                     /name="rep_cluster_2214"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(19743..20485)
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          15940..16214
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="94.565"
                     /coverage="100.0"
                     /evalue="4.71e-46"
ORIGIN
        1 ttggtaataa aacgtttaga aactgtttat ttatataatt ttcgatactt agattatata
       61 atgaataata tcttagtgca agcacctaga ttattaaata aacacaaaaa atgtaagcgt
      121 tttattacct cttaccaaac taaaattcgg aaagaggttt ttattatgtc aattaaactt
      181 tacaacataa atgaggaata cagagaaaag ttttatcaaa taccgaaagt attttttaca
      241 aatcctaaat atatcaagtt atccaatgat gcaaaaatgg catggggtat tcttagagat
      301 cgtttagatt tatcaattaa aaatggttgg gttgattcta aaacaggtaa tatttatttt
      361 tattacaaaa atgaaaaccc acaaaatata ttaaattgta aaaaagataa agtaattaaa
      421 ataaagaaag aacttaattg aagccgaatt actactacaa gaaagacaag gtttaaataa
      481 gacaaataaa ctttatttag ttaaaccaga agtaacagaa gatgatattt ataaaattca
      541 aaagcaagaa aacactgttg agagcagcaa tggcaaggaa gtcggaaaaa ccgacttcaa
      601 gaagtcgata aaacagaatc taatgatact gaacttagct atactgaatc taacaatact
      661 gaaataaatg atatgaatga cttgaatgat atagagtccg aaaatgaaat tagtaatcat
      721 tcaagtcaat gcaaggttat ttaatgcaaa caattttaac tgaatttgaa gaaacacatg
      781 cactttatat gcgccgtaaa aacatgaaac aatataatat ctttaatcaa tcattcaaat
      841 gattttataa caatcaaaga tacatcaaaa tatttcgtta aatcatctga ctttttaact
      901 gatagcgatg aaaaaatcaa gaaattgtca gtgatctaga aaaagatttg tatcgaaaac
      961 gtatgttaag ttatggtgga ttgcttaaat aaaaacataa aattttaaac ttagacgatg
     1021 ctgaagatgg caatttaatt aatacaagtg atgaagataa aatagcaaat gaagaagaaa
     1081 aggcacattc gattacggca attttgaaaa gcaaaattat tatttaaggc attagtgata
     1141 actgatgtct ttttttatta cttttttgta aaaaaagtgc tgtcttattt ttgtgacaaa
     1201 tgctgtatgt agtgtcacaa aagtgtgaca cttgagcttt ttatgacccc acacaaaaac
     1261 attttcgaag ccttgaaata tctggctttg ccagatcccc cattcattga tggggacaaa
     1321 tttcccttat gctcttacgg agattttaga gttaaattaa aatttctaag tttttgataa
     1381 gaaaagccct gcaggaattt agaagaacgt ggggaagttt taaagaattt tatgctaatt
     1441 tttaatttgc atgtaaatgg gcagtgtcta aaaaatagtt attgtttttg ctcaaatttt
     1501 tgtttttgaa aatagcatat atttatttgg ctcatatttg cgttttaaaa gcgtatataa
     1561 gttttagata taaaactata tgaatcaccc ctaaatcttt aaaatgccct cttaaaattc
     1621 aaaataaggg cataaaaaat aaaagccccc ccagataaag tgaggtagct ttttctttcg
     1681 acgccgtatc gtcgatgtaa ttcaaaaaag ttatgggcta taaatctaca tcactttttc
     1741 aagaatgtag tagcaatatt caacgcaaat taatttttat aactgctcgg aatatctcaa
     1801 gccgtttctt taattttgaa ataaaaaaat cgacgaaggt cgattacgtt tttgcacatg
     1861 tcgatttatc cgacgtataa gtgcgccctt acgggattta actagattat aacgacgaat
     1921 tttagacctg taaagcaata acaattaggt ctaccaggta gataaagtgt acaaagtaga
     1981 accgaaaaag ttatttattt tgaagatttt tcgtagatat aatttgctaa taaacttcct
     2041 aaaactgaat aaagaaaaat agttaaactc atgtaatcac tccataattc tgaagtgtct
     2101 ccatgtctac gcatagacac gcatttatgc cgagaaaatt tattgtgcgt tgagaagaac
     2161 ccttaactaa acttgcagac gaatgtcggc atagcgtgag ctattaagcc gaccattcga
     2221 caagttttgg gattgttaag ggttccgagg ctcaacgtca ataaagcaat tggaataaag
     2281 cacctatgat tatttaaaaa tataagttat aatacattca aaaatatttt tgaatgaggt
     2341 gtattatgat tcaaacggtt gttgctgctg ctgttcttta tattgctaca gcagttgatt
     2401 tattagtaat tttattaata ttttttgcta gagcaaagac tagaaaagaa tatagaaata
     2461 tttatgttgg tcaatattta gggtctatta ttttaatatt agttagtttg tttttagctt
     2521 ttgtattaaa ttatgttcca gaaaagtgga tattaggttt attgggttta ataccaattt
     2581 atcttggaat taaagtggct atttatgatg attgtgaagg agaaaagaga gctaaaaaag
     2641 aattgaatga aaaaggattg tctaaattag ttggtacggt tgcaattgtt acgatagcaa
     2701 gttgtggcgc cgataatatt ggtttatttg ttccgtattt tgtgacatta agtgttacta
     2761 atttattact tactctgttt gtctttttaa ttttaatttt cttcttggtg tttactgcac
     2821 aaaaattagc taatatccca ggaattggag aaattgttga gaaatttagt cgttggatta
     2881 tggctatcat ttatatagct ttaggtttat ttattattat tgaaaatgac actattcaaa
     2941 caattttagg atttatattt taatttaggg tgtgatttta tatgagttat gaaaatactt
     3001 gtgatgtgat ctgtgtacat gaggataaag ttaacaatgc tttaagtttt ttagaagatg
     3061 ataaatctaa gaaattactt aacattttag aaaaaatttg tgatgagaag aaattgaaaa
     3121 tcatattatc tttgattaaa gaagatgagt tgtgtgtttg tgatatttct ttgatattga
     3181 aaatgagtgt tgcttcaact tcacatcatt taaggctttt atataaaaat gaggtacttg
     3241 atttttataa agatggaaag atggcatatt attttattaa agacgatgaa ataagagagt
     3301 ttttctctaa aaatcaggag ggtttttgaa acgagtgaaa cgagtttctt cttgtcttga
     3361 tactataaaa aacaaagtta tataacataa gacgacttat cggaagttat ctatcatcgt
     3421 atattcggag atgatataat atacaggtcg cctatctctc aggcgtcaat tcagacgcag
     3481 agaggaggtg cattactttg ctaatcattt tcgttcacat catagcacca gtcatcagtg
     3541 gctgtgctgt tgcgtattat acttattggc ttagtaaacg caacaaataa ttaataggcg
     3601 actttataag ccagcatcga aaaaatcccc acactattgc agtagtgtgg ggattggtgc
     3661 attaattgtt aatcattttc gttatctaga ttataacact ggttagtaga ggaatgcaaa
     3721 aagataatat tttaagtagt ctttttggat attatcatat gatatattta tgtaaattga
     3781 ttttttatta aaggagcata tatgagtaat actaaaatta aatatcaaat ttttatttca
     3841 tcaacttatt tagatttaat agaagagcgt caagcagtag tagaagcagt tttaaacagt
     3901 aataatattc cagcaggtat ggaacttttt aactcaagta gtaaaagcca atgggaaata
     3961 ataacacaat ggatcaatga atcagatgca gtgatattat tgttaggttc tagttatgga
     4021 acaattgata gtgaagaaaa tattagctat acagaaatgg agtacaattt tgctaaatct
     4081 ttaggtaaac ctatatatgt ttttgagatg aataaagcat ctaccgaatc cgcggaaaag
     4141 tctaaaaaat tagatgagtt taagacaaaa gttaaagaaa atagactaat tagtccaaat
     4201 attaatgata tttcggaatt aaaaagtaaa gtatctcaga ctttaatgca aagtgtacct
     4261 agtgaaatta aagaaaatag tggatggata agagtacagg attgtggtaa aaatgtaaaa
     4321 aaattaaaaa aattggatgc tatacaaaga gatttagata catatgattt tttgaaagaa
     4381 gaactttata aaatattcat gtatgtaaaa actttttatt tccagcacac accatttgat
     4441 gatagttata ttgaagatat agaaaactac ctgctaaatt atgaaaataa tccacataaa
     4501 tcattcatga aaataaaagt ttatgattat aaaaactttt taaaacattt aaaaaacata
     4561 ttgattttaa ttaaacaagg aaaaaagcca ttagctcaag ccggtcattt taaattaagc
     4621 ttttacgaag aggatttaaa attgttacaa aaaaattata agactacgct agtcgatatt
     4681 aaaggattga ataaacattt ttataaggaa tgtgataggt gcttaaaagc atataatatt
     4741 tttattgagg gtataaataa acatttatat gaatgatata agtacaccct aatcatacat
     4801 atataattgt tgtcacttta ctcgatatat gagaatgact ttacctaata aatgagaaaa
     4861 gcaacgcact atattaaaat gcgttgcttt ttctattatc gaatacctat aactaaacta
     4921 tctctagctg tttctacaac ttctgtactt attttatcta aaccatttat atccataatt
     4981 ctgtctatct gcgcaaataa acgatgaatc agcctaaaat tcccttttgt aattttaata
     5041 atcgtcgtta ttgcctcata atcagtaaag tcttcgagtt ttaaatcaaa tcctaagtct
     5101 tgccacttat attctaatat atgatgcgtc tcatctttac ttagattatc aaattcatgc
     5161 gcaaaaccta tacgcgaata tagttgagga taacgagata gttttttctc tatacccggc
     5221 ataccaataa atatcattgc taaattatgt tcatcataaa tagctcttaa ttgctctaaa
     5281 tgttgcactt taaggcgatc aatctcatct actataatta aatcaatata tttaaacata
     5341 tcactataat gtttactatg ttcatgtcca tacttattta caacatgtaa tttttgaccc
     5401 aaatcaatga ttgcagtaat actatataaa tcattcctta atttagtttg tttttctgct
     5461 ggtgcattat aaaatatttt atccaccgat agtatgtcat cggtcgtttt actagctaaa
     5521 tcttcccaac ctctatggtt aacttgtttt tcaatagtat cccaatttgt gtaataccta
     5581 gacgataaag tttttccgac accaggttga ccataacata taccaatata ctgatattta
     5641 atacaagcat cacaaaattc agcaaagcgt ttatactctt tcgtttcaat gaaattttga
     5701 tttttagtca ttacgatatc tctttaattt tttgacgttt ttagtcgttt cttgaggtga
     5761 ataaccacaa tttttttctt ccttaattaa ttccgtggta cttggactag caatattttg
     5821 ttttaagtgt tttcttctct gactacgagc gtgctgtatg tcttttatat ctatggagta
     5881 atcagctatt tctggacata tagcagtaca aagaaattca tctctataaa acacacgtat
     5941 ttcagccata tcatttgggt tataacgaat cagtacatat tcacctacat aagcttctag
     6001 attagtatta ctgtatcgaa aaccttgaaa atgaatgcca tctgaatgaa cttttctaga
     6061 tttaggtatt tccaacaata ataaatcaag ttgttctaag ctacttggca tattagggaa
     6121 aaagtgatta ctattccaat gactgatagg cgtggtatga atagtactat gttctttttg
     6181 attataatct tcaattaaaa agtaacgtaa tttttcttca aaattgtgaa aatttattag
     6241 attactagga gtatcattat tgtttatata tccaggcagt tgttctaaga aagtttgatt
     6301 aactgtctga aagaatcgtt ctatttttcc acgaccacga ggaacaccaa ctttcgaaaa
     6361 catcaagtta attttcaaat caatagcgac ttgttccata tgatgtgaag taaagtcact
     6421 tccatgatct gtgtagaatt tttcgggtat accacacact ggccaattgg tatcattttt
     6481 attccatatt gcttggtgta gtgttaatgc tgtgttttga gcattggggg gcatcaaaac
     6541 ttaagaaata gcctgcaatt gcacgactat agtcatccat aataatagtt agccatggtc
     6601 tattgatatt acctttttgg tctaatataa agatatctag caaagtatgg tctgcttgcc
     6661 atatttcatt gggtctcgag gattctctaa tttgtattaa atcgtactta ttttgatagt
     6721 atttttcacc ctgatgagag aaatcaataa cagacttagg catcgcttta ataacactat
     6781 aaatttgttt ataacttggt atatcaaaat tattttcttt acagtaatta gtgattttcc
     6841 tatgaattgt ggctatacta tttcttttat tcataagcgc aaggcgttca atttcatcaa
     6901 ttatctttgg ttctatttta cgtgttcctt tatcagctct tgtcgcatag attagtcctt
     6961 taagtccttg ttctttatat gacttattcc acctataaag ggtgcttaac gcaatccctt
     7021 tacttttaga aatacttgat aaagattgtt cgcctaggat aaaaggtttt ataatattgt
     7081 acttttgagt agctttttta cgtttggctt cagaaaaatt agttagatac ttctccttgt
     7141 ttttcatctt ccttgtcctc caatttattg aggtaacgat aaattgttgt acgtgaaaca
     7201 tgccactgtt ctgcaattgt cttaattggc gtgccattat cataaagggt cttaagtaag
     7261 tttaaatctt tttgatttaa tttttctggt ctgcctccat atcggcctct agcacgtgct
     7321 gcaattcggc cagctgaaga acgctctaaa attaaattac gttcaaattc tgcaaatgct
     7381 gcgaataaat gaaataataa ttgtccagtt gaacttgatt tatccattgt tatattttct
     7441 tctaaactat ggaaacttac acctcgttcg ttaagctcat taactaatgt gattaaatcc
     7501 tccatattac gtcccaatct atctaatctc caaacaacaa tcgtatctcc tgacctcgca
     7561 aattcaattg ctttatctaa accaggtctt ttactttttg aaccactcat atggtcatta
     7621 aatatctttt cacaaccata tgtatttaat cgatcctcct gtaaatttaa attttgtaat
     7681 ccagttgaaa ctcttgcata acctattttc aaaatacaaa cctcctatat acatcttcag
     7741 tgtaccataa cttaattaca aggtctttta tgaacataga ttttttgttg ggtttttgaa
     7801 cacataatcc tatgtaattc ttacttattt agacataaaa gaagagtgta cagaaaatgg
     7861 ttattttctg tacactctca tctttaataa tatattttaa atgtcattaa caaaactaat
     7921 ttaataagag tcaagcatag tttacatatg tattatgttt gaaacatacc tctaattact
     7981 ttttactaat atcatttaaa atatctcgca attcttcaat ttctttgtta tttaattctt
     8041 catttttcgc aaaattcaac actaaacttt tcatatcccc tccatacagt ttattaagaa
     8101 aggttttagc agttttcatt ttaatatcgt cttctttaat atttgatgag taaaaataaa
     8161 tattttctga tttgtatcgt tttataatct cttttttata tagtcttgtg attaatgttc
     8221 taatcgtttt atcactaact tctttatatt tttgaatttc aactacaatt tcattagctg
     8281 atactgattt tttatcccat attatattca taacatccca ttcagccata gatatttcaa
     8341 cttgcttatt ggccatttaa aacacccatt ccttttaata ttttttcact tattaattca
     8401 gcatttttcc cagacgggtt tccatctgat aaatgtgtag caaaataata cttatcatga
     8461 tttgtaatta cgtaacctac aaaccaccca ttattatact tcccgtttac tatacctgta
     8521 cctgttttcc catacagttc atacttttca tttttcttaa tcaataatga agaagataat
     8581 tgattctttg cttttttact aaaatggtta ttttgttcca tcatattttt aaaaactatt
     8641 acttgttcaa gattagatat tttcaaacta tcttccatcc aatagctttt ataacttccc
     8701 aaattttcat taccataatt taattgcttg agttgagccg cagtatagtt ctttggtatt
     8761 tgattactaa tacgttcgaa gtaccaatta actgaatttt gcattgctgt atttaaatct
     8821 tgttccttat tccaagactc gaaaagataa tgtttatgat tccatgacat acgtgaattt
     8881 ttatcactta taatatgacg gtcaagtcca aacagtgcta aataaatttt gtaagttgaa
     8941 tcaggagaat atctttttct actttctttt tcattataaa tatagtattt gtctttcttc
     9001 atgctgtaca taacgaaaga tccactattt gaaccaaaat ttttactttc atctaaaatt
     9061 tggtaatcgc tttgtaaggg ctttttataa ttataatcag ttaaggattg ccccattaaa
     9121 aactggcttt gaattatcat gataaaaaaa gtaaaaatac aaataaaaat tagaattaat
     9181 tttgactgct ttttcagatc ggcttctttt atattaatta atctattttt gagtaatgat
     9241 tttttaccat taaatgaatg gcttaatata tttttgttga aaaatgaggt ttttaatacg
     9301 gagtccataa tagattccgc ataagtttta aattcatttt tgttaatatt attaaggaca
     9361 aatctatcgg cttctacttc attgtcatga attatctttc tttttacaat atgtactaat
     9421 ggattgtaac tcataataat agagaagata ttaaagataa ttaaatgtaa agtatctcta
     9481 tttttagcat gagcatattc atgcagtatt atatatttta gtcttttatc aattacactt
     9541 ttaaaatatg aactaggaat caaaataata tatttcccat accaaaaagt tattggagat
     9601 tgaatagcct ctgcttttcg aatcacaata ttttttttat attgatggtt gaaaagtatc
     9661 gtatctattt tatttttttc attttcgttt agataaagtg actgtttctt taaatattta
     9721 agatataata aggctttcaa aaatttaaaa cttaaaataa taactaaaac tatccaaata
     9781 actgtgcaga tattatcaat tgaatcccaa ttaaacttat ggatatctgt tgcgaactct
     9841 tgaacaggtt tggtggtaat tatgttatgg ttcaagtcgt gtgacttact ttcaactgtg
     9901 ggcgcttgat tattcacatt attaaatttt ataaaagaga atttaattgg gataaaagga
     9961 attaatccag caagcacagt tagataccaa actttataat ttaaactata attaaaatag
    10021 cgttttaata tgtacctaaa aaatactaac aatagaaata taaaacaaaa gcttactaca
    10081 ctcattatta gtaatttagc cattttgaca ccttctttca aatatttata ataaacaatt
    10141 gacatcaata ttacaattgt aatattattg ttttgtaaaa attacaactg taatatcgga
    10201 gggtttattt tgaaaaagtt aatattttta attgtaatgg ctttagtttt aagtgcatgt
    10261 aattcaaaca gttcacatgc caaagagtta aatgatttag aaaaaaaata taatgctcat
    10321 attggtgttt atgctttaga tactaaaagt ggtaaggaag taaaatttaa ttcagataag
    10381 agatttgcct atgcttcgac ttcaaaagcg ataaatagtg ctattttgtt agaacaagta
    10441 ccttataata agttaaataa aaaagtacat attaacaaag atgatatagt tgcttattct
    10501 cctattttag aaaaatatgt aggaaaagac atcactttaa aagaacttat tgaggcttca
    10561 atgacatata gtgataatac agcaaacaat aaaattataa aagaaatcgg tggaatcaaa
    10621 aaagttaaac aacgtctaaa agaactagga gataaagtaa caaatccagt tagatatgag
    10681 atagaattaa attactattc gccaaagagc aaaaaagata cttcaacgcc tgctgctttc
    10741 ggcaagactt taaataaact tatcgcaaat ggaaaattaa gcaaaaaaaa taaaaatttc
    10801 ttacttgatt taatgtttaa taataaaaac ggagacactt taattaaaga tggtgttcca
    10861 aaagactata aggttgctga taaaagtggt caagcaataa catatgcttc tagaaatgat
    10921 gttgcttttg tttatcctaa gggccaatct gaacctattg ttttagtcat ttttacgaat
    10981 aaagacaata aaagtgataa gccaaatgat aagttgataa gtgaaaccgc caagagtgta
    11041 atgaaggaat tttaatattc taaatgcata ataaatactg ataacatctt atagtttgta
    11101 ttatattttc tattatcgtt gacatgtata attttgatat caaaacctga ttttcccttt
    11161 attattttcg agatttattt tcttaattct ctttaacaaa ctagaaatat tgtatataca
    11221 aaaaatcata aataatagat gaatagttta attataggtg ttcatcaatc gaaaaagcaa
    11281 cgtatcttat ttaaagtgcg ttgctttttt ctcatttata aggttaaata attctcatat
    11341 atcaagcaaa gtgacataat tgttgaattt atagtaactg aaacgtatga ttagggtgta
    11401 tattaattat gagatggaaa tcaatgattg ttggctatgc gagagtatca tcgaacgatc
    11461 aaaatttaga aagacaactt gaaaatttaa agacgttttg tgctgaaaaa atatttacag
    11521 aaaaacagtc tgggaaatct attgaaaata gaccagtact tcaagaagca cttaactttt
    11581 tgaggatggg agatcggttt gtagtagaat ccattgattg tttaggtcgt aattatgatg
    11641 aagtgattca taccgttaat tatttaaaag acaaagaagt acaattaatg attactagct
    11701 tacctatgat gaatgaagtg gttggcaatc cattactgga taagtttatg aaagatttaa
    11761 ttattcaaat attagcaatg gtttcagaac aagagagaaa tgaaagtaaa cgtcgacaag
    11821 cgcaaggaat tcaagttgcg aaggaaaaag gcgtatataa agggcgcccc ttactttatt
    11881 caccaaatgc taaagatcca cagaaacgta ttatttatca tcgcgttgta gaaatgttag
    11941 aagaaggcca atcaattagt aaaattgcga aagaagtaaa tataacaagg cagacgattt
    12001 acagaattaa aaacgataat gatttgattt aataaacttt gtttcaatgc aactgagagc
    12061 ttctcacagc gtctcaaaac agatgattat aatctattat gagtttttaa taataagaca
    12121 agaaaagaga gcgtaaatat gctctctctt tttctcatta acgaatgttt ataacgcaat
    12181 catgatgaga gtattaatac agttaattat ttgaaatact ttagtttata taatgttgaa
    12241 ttataggtag tgaaattgta tttattatac attgtcatat cgttgtttaa tgatagttaa
    12301 tttaaggata atagaattaa tattatatat agatgaacaa aacaagcaac agagcagaaa
    12361 aaacactttt agattatttt tactcattct ctattttatt tatttttgct ataataaata
    12421 aagaatatta aatggaggtg tttttatgaa aaagaaattt gtttctagtt gtattgctag
    12481 tacaatctta ttcggcactt tattaggtgt aacttataaa gctgaagctg caacagtaca
    12541 tgtagctggt ggtgtttgga gccatggtat tggaaaacat tacgtatggt cttattatag
    12601 tcacaataaa agaaatcatg gttcaacagc agtagggaaa tattcatctt ttagtggtgt
    12661 tgctcgacct ggtgttcaat ctaaggcatc tgctccaaag gcttggggtg gaaacaaaac
    12721 attttatagt cttcactaat tacatatatt aattaaggag aatagacaga attaagtaaa
    12781 cttaattctg tctattctct tgaaagaggc aatatgaaaa aattcaaatt atttttagat
    12841 tttagtactt tattattaat ttcagggcta ttatttttat ttttcttcaa agaaaatgaa
    12901 gaaattatac ctgaaagttc caatatttta acaatctcta attgggataa atctaacagt
    12961 aaatcaaaag tgttagatgt cattgaatca ggcgccaaaa atcaaaatat acaaataatt
    13021 aaatccgtta aagattttga taataaaaaa gaattttttg ttttcaactc aaaacgaaat
    13081 aattctgact ttatacgtaa taaaacatca cttttaactc catcagattt attaaacaga
    13141 gagataaaag gaaagtatta tattattggt gaacatttca atgtagaaga gcttacgagt
    13201 gaattaaaaa aagctggttt aacatctgaa gttgaataca taaatagaaa catattattt
    13261 tttgaattag tcatagataa tgatttatta gtgcctttca tattcttagg cgtattatat
    13321 cttttgtact tcttatatga cagaggatat aatttgaaat tttatgctat tcaaaagcta
    13381 catggctttt caactacacg cattattttt cataatattc atataaaaat catttattgg
    13441 ctagtactta ccgctatttt ctttattgct aatatattaa tcattcatat agccaattta
    13501 gaattggatt tcttaatgtt tattcgtaga tttatcgtgt tgctttttgt ttttgcttgt
    13561 attactacat tgctgtggct gatttcgtat agtcttcttt tgaagttaag tattccatta
    13621 atcttaaaag ggaaaaaagg atataagttt tcaatattta tgggtacctt caccaaatgt
    13681 atcatggtgc taatactatc ttttttactg gcacaaaatt taaatgctta tacgaagtta
    13741 aagaatatat atgactctga aaaaatctgg caaaagttag ataattacta tacattagag
    13801 atttctccta atattagaaa ttcagaagaa aaacaaattt tagaaactaa tatatacaat
    13861 ttaattaaga aaagcgaaca acttggtgga ttgcttttaa agaataataa tatagccaat
    13921 cccgataaaa acaattacat tcctgaaaat ggcaatgtct tttttatcaa taacaatttt
    13981 ctgaatttct ataaaaatat aaatcatgat tttaaaatga ttgacaatca ttcggataaa
    14041 ataaacgtgt ttattcctcc aaggttacaa tatcaaaaat ctgaaattca aaaaaatcac
    14101 caaggatgga ttgactttca aaagcaacaa aacaaaaaag tagatgtgca agtactgtca
    14161 aaaaacgtat ctgttttttc ttttgatcgc acaactaatt tgaaatttgg gtatctagat
    14221 tctccaatag taatgttgtt gacacttgac gatttaacag gagattttta tttagctgct
    14281 gtttctcaag gtggatatct atttaaagat ttagatacac ttaaacagtt gcttaaagat
    14341 aatcacctag aagaagaaat tagcggtata actaattaca aggattctgt gttaaatgaa
    14401 ttaaatgaaa cgaaaacaaa aatgataata acaatagtta ctattattat taacgttttc
    14461 attcttttga tagctactgt atttgaaaca attcaatatt ttagctggaa taaaaagcaa
    14521 ctattattaa gaaaaattca tggttattca ttattcagca gtaatgtacg ttatttaaca
    14581 atttctatct tactttctat tatgttagct tacactacgc atattttatt tggttcaaag
    14641 atattactat tcataataat gtctattgct attattcaac atttacttca aattgcttat
    14701 attaaatatc ttgaaaaata ctttaaagat ttaatgaggg agatttaaac aatgaaaaga
    14761 actttaatta ttgtaacaat tgtactatta atcatcatac ttagtctgtt attggttaga
    14821 aatgagcatt tagatcgttt taacccactg ttaaaagaaa aagtatctta tgccaaagtt
    14881 ccaaaagata cccaggacta tagaaatata actgtatact ctaaaaatgg agaaaaaaag
    14941 agttataaat tggatttttt aggttatgat cctaaaaaag aatatgtgaa agtaaatcat
    15001 aaagggaaat atgtgcgttc gatagaatac attacaaaag atattcctag ctttttaaaa
    15061 tgaggtgacc gatagtgata aaacttgaaa atgtttttgt aaaaaaaggt aataaaaaca
    15121 ttttagacgg atgtaacttt aattttgaaa aaggaaaatc atatgcttta gttggagaaa
    15181 gtggcgctgg aaaatctact ttacttaaca taatcgctgg gttcgaagat gtatcacaag
    15241 gaagcatata tattgaagat aagttactaa aaaagaaagt cgatttttat agatatacgt
    15301 tagggtattt gtttcaaaat tttgctttac ttgaaaatca aacaatcagt caaaatttag
    15361 atttagccct aaagttcaaa aagaataaaa aagataatat gaacttaaag aaagaagtat
    15421 taaaaaaggt cggcctagat ttagatatca agagaattgt tagttctcta agcggtggtg
    15481 aacaacaaag agtagcattg gcaagattaa tattaaaaga tccgaaaatc attttagctg
    15541 atgaacctac tgggtcacta gatacgaaaa atggaaaaat agttattgat ttattattga
    15601 agctacttga tgaaaataaa actatgattg tcgtaacgca tgatttagag cttgcgaaac
    15661 gatttgatgt catagtcaat atttctgagc ttagaagtta agaaatattg ataggtatag
    15721 ccatacatag agaaaaaaca atatgaaata tgattagtca ttacttttga gttttttaat
    15781 ttaaggactg gattttccag tcctttttta tgatgacaaa aaacaagcct cgcagagcac
    15841 acgtttttaa tgacttattt ggtttttaat aagtctagta tgttaaaact tttctgtgtt
    15901 taggtgttat aatcatatgc agtggaagtt gatttattat gtcttattca attattcgag
    15961 ttgttaaagt gaaatcaaaa acaaatacaa gaggtattca aagacatatt caaagagaaa
    16021 ataaaaatta tgaaaatata gatattgatt taagtaagtc atatttaaac tatgatttag
    16081 tcaatgatac taagtttgat tttaataaaa aaattgatga gaaaatcgaa aaaaattata
    16141 aagggaaacg caaaattaga acagatgcca ttaaacatat tgatggatta attacatcag
    16201 ataatgtgtt ttttaatcaa ttatctgaag aagagacaaa atagtttttt aagcatgcta
    16261 aagcgttctt ggaagaagaa tacggtaaag aaaatctttt atatgcgaca gtacatatgg
    16321 atgagataac accacatatg cattatggcg tagttcctat tactaaagat ggacgtttaa
    16381 gtgcgaaaga agttgtaggt aataaaaaag cattaaccga attccaagat agattcaata
    16441 cgtatattaa taagcaaggc tatgatttaa aacgaggaat ttctagacaa cttacaaaag
    16501 aaaaacatga tcaagttagc cgttataaac aaaaaacaga atatcataaa caaatgcata
    16561 tgcgctagaa gcaaatagag gattatttaa agcaagaaaa tgataaattg atacaaaact
    16621 accaaaaatc attagatacg cttaaaaagc ttctgagtgt catgtatgaa attaaaacta
    16681 aaaatgtagg tggatggttt cataaagaga agcaagaaac aggcaatatt gtaattacta
    16741 aaactgattt tgaaaaatac actaaacaaa ttaaagcagc acagatgata ttagatgatt
    16801 atgaatgtat taaaagtggg aagtcattaa aaaaagcaga gaaacaaaat gaaagtttag
    16861 ttaatgaatt gactagtgtc catatggaaa atgaaaagct ggttgaagaa tttaatgatt
    16921 tagcacaacg ttataattat ttgttgtcag agaatgaaaa gaaagataaa gaactaaatt
    16981 atacgcttaa gttattcaat caagttttta aaatcattaa aagtatgatg aaagaagagc
    17041 gttatcatac actaataaat catattgata atcatttaga caattctaaa atacgtgaag
    17101 taatgacgat agataacaat gatgaacagt tctttaagaa gaaatatcaa gcacaagaac
    17161 gagaaatcat ttttaaagaa gatagagaag atggttatac attataaaaa tagatattta
    17221 aatgcatttg tttgaggtta attatttttt aggatgaaaa ataggtagcc cccctcgaac
    17281 tttttaatat atttttataa atctttttaa aaaccttttt aggggcttgt tcagccctag
    17341 agcaacaagg gatttcaatg cctaaaggag tgtttttgcc acataaaagg agtgtttttg
    17401 ccacataaaa ggagtgtttt tgccacataa aaggagtgtt tttgccacat aaaaggagtg
    17461 ttttaaaaag ttgtactcct tttatggttt gacattgata ataaagtagt ttattgtgaa
    17521 taaaagtttt caaatgggag tgtatattca aacgatactc ctttaggttc gtaataaagg
    17581 gggctgtatc atgacaggag agacagttgt atataaaaat gaaatgaatt tagttccatt
    17641 aaggcgattt acagctactg aaattaattt attttttgcg atgtgtaata aattaaaaga
    17701 gcaagatact aatacattac gtttgtcttt tgatgaatta aaaaaattaa gtaattatag
    17761 tccagaaaca cgtaatatta atagatttgc taatgattta gataatgtgt ataaaaagat
    17821 gttgaattta accattagat atgaagatga tgatgtaata gaaagattcg ttttattcaa
    17881 tcattataga atccataagc gagaacaata tctagaaata tcaacttctt caaatttaaa
    17941 acacatattg aattcaatta ctaataattt tacaaaattt gaattaaaag aaatgactag
    18001 gcttaaatct acatattcta aaaatatgtt tagattactt aaacaataca aacatacagg
    18061 ctatttaaaa attcacatcg atgattttaa aaatcgttta gatataccta aatcttatcg
    18121 tatgactgat attaacaaaa atgtttttaa acctattatt attgaattag gttctatatt
    18181 taataatctt actatcaata aaatcaaagc gaaaaaaggg cgtaaaattg aatggataga
    18241 gttcacattt gacgctgaga aacgcattca taacaaacga caacctcaaa tgtccaagat
    18301 agataaatca agacaatatg tgaggcgtga aaagacgcct aaatggttag aagaacggtc
    18361 atatgaaaag caacctcaaa aagattacga cccacaatta gagaaagaac gagaggattt
    18421 tttaaaacaa cttgaactga attgggaata acgcaacttt tcgttgcgag ttggttaact
    18481 aaaagtatcg tgacttttca attattttaa ttatagtttg agttaaggag tgattttatg
    18541 aaattagctg aagctataaa agaacagaga gaattaaaag gatggtctca agaggaatta
    18601 gccaatatat taaaggtttc cagacaaagt gtttctaaat gggaaagtgc caaaaactat
    18661 ccttccttag atattttgat tgctatgagc gatttattcg gaatctcttt agagcattta
    18721 attaaaggag atgcacgttt taaaaaagtt attttagagg gaaattatag agagagtaac
    18781 agggtacctt ccatagttga ttttctttat gatttttggt ggcttttctt tcctgttgcc
    18841 ggatttttag tttgggccat tcattcgttc atgggttgat tttaaaatca aaatttaatg
    18901 cacatcaggc aatatgaaaa aggaaagtat ttttacgaca ccttgaaatg tattgataag
    18961 aatagaagag tttacaaaag gcaatatgaa atatatacta aaagtaacaa gaatttcgtt
    19021 tgtaaacgca caaaaccccg aactattcgc cgtagttcgg ggttttttgg tgaattggct
    19081 ttaatcgtct atattatttt ttatcacgtt tatggagcta ataaccaaat aacgtaacga
    19141 gacaaccact gattgccgtt gtcatgatgt gaacaagaat ttcattcata aatcgcacct
    19201 cctctctacg ccgaattgac atctgagaga tagacgacct tcacattata acaaatctct
    19261 ccttccatga aataacatga atattaataa atgttgttat atattaaaga taaataaata
    19321 taagggtggg attgataatg tttggcgatc aaagacaaga agctacaaaa tatgtcatta
    19381 aagaaggtta tcaagatatt tatttcctca acaaaaacgg ggaatggtat tatttcgaag
    19441 taagaagtgt ctggcgtggc aaacatatta ttagagttaa agatggtttg ttaggttgga
    19501 gaaaagaaat agtaactgaa taaagataca aaatacttgc caatgcaaaa gaatgaaaac
    19561 gcgtcaaatc aacgatgtat aaaagatgca taaaagataa tgaaagtaaa aagccataaa
    19621 tgccgtcata taggcattta tggctttttg tttggttaac ataatcgatg attatcagaa
    19681 gttcaattca cataaaaaag cacggctaat ttatgaactt gtcgtacctt tttaattaaa
    19741 attagttacc aaatagacga ctccaaaacc cctttttagg ttccgtttct tcactctttt
    19801 cttctatatc actatcattg tcatttggat tagctgaaac gtcttctctt tgtgcttctt
    19861 caccttgtgt actttcgtcg ctttgacttc cagatatatc cttatattga atctctgttt
    19921 ctttagtttc ttcctgatct cggttaatat ttacaggact agtagtatat gttttttctt
    19981 gtgcatcaac gttttgtcta gcgttagtag atgtatcaaa gggataatta aggtgttttt
    20041 ctttttctaa ttgattttct aatttttgaa tctttttatt actctctaat gccagaactt
    20101 gctgattctc aagcaatttt gatctttctt gcaactcttt tctgtaaaat tcaattgttg
    20161 tttcatgacg actttcttgt ttttcaattt gattatttaa agtattaatc tgatttttaa
    20221 gtatttctac tatttgagca tcgcttttag attcaaaatt aatattatcc gactcttttt
    20281 tttgtttgtc ttcagtagca ctttcaaaac catatttctt tttattttca tttactcttt
    20341 gaatgatttt ttctatatcg gtatcttctt taataaacga agtgttttcc tgttttattg
    20401 tctctatatt caatctctta atattattaa aaatcgtttg cttactaacc cctaattctt
    20461 cactcaacct ttttacactt ttcatatcat caacccttta taaaatgttt ataaaccctt
    20521 agtaaaatat tataagctta taacgattaa taataaagta atcgacaaat aaaaatataa
    20581 attcgccaac ctttttatca agggtttgta aagggtttat ggtgtttatc aaaggtttat
    20641 aaacctatat tttccctttt ttaagtttat tcaaagtgct ataataacct taatataaca
    20701 aaaaccccaa ctactggtaa tagtcggggt
//
