LOCUS       NZ_CP046275            26086 bp    DNA     circular CON 04-APR-2024
DEFINITION  Enterobacter hormaechei strain E70 plasmid pE70-TEM1, complete
            sequence.
ACCESSION   NZ_CP046275
VERSION     NZ_CP046275.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN13335391
            Assembly: GCF_009728975.1
KEYWORDS    RefSeq.
SOURCE      Enterobacter hormaechei
  ORGANISM  Enterobacter hormaechei
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
REFERENCE   1  (bases 1 to 26086)
  AUTHORS   Xue,M.
  TITLE     Extremely drug-resistant NDM-1-producing Enterobacter hormaechei
            from China
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 26086)
  AUTHORS   Li,Z.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-NOV-2019) Center for Infectious Disease Control,
            Center for Disease Control and Prevention of PLA, Dongda street 20,
            beijing, beijng 100071, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 18-JUL-2019
            Assembly Method                   :: unicycler v. v0.4.8-beta
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 130.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009728975.1-RS_2024_04_04
            Annotation Date                   :: 04/04/2024 04:39:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,693
            CDSs (total)                      :: 4,574
            Genes (coding)                    :: 4,490
            CDSs (with protein)               :: 4,490
            Genes (RNA)                       :: 119
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 7
            Pseudo Genes (total)              :: 84
            CDSs (without protein)            :: 84
            Pseudo Genes (ambiguous residues) :: 0 of 84
            Pseudo Genes (frameshifted)       :: 25 of 84
            Pseudo Genes (incomplete)         :: 63 of 84
            Pseudo Genes (internal stop)      :: 14 of 84
            Pseudo Genes (multiple problems)  :: 15 of 84
            Pseudo Genes (short protein)      :: 1 of 84
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP046275.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..26086
                     /organism="Enterobacter hormaechei"
                     /mol_type="genomic DNA"
                     /strain="E70"
                     /isolation_source="urine sample"
                     /host="Homo sapiens"
                     /db_xref="taxon:158836"
                     /plasmid="pE70-TEM1"
                     /geo_loc_name="China:guangzhou"
                     /lat_lon="23.13 N 113.28 E"
                     /collection_date="2018-02-04"
                     /collected_by="Lanfen Lu"
     gene            1217..3181
                     /locus_tag="GMA21_RS23195"
                     /old_locus_tag="GMA21_23195"
     CDS             1217..3181
                     /locus_tag="GMA21_RS23195"
                     /old_locus_tag="GMA21_23195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_004178196.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            3181..3912
                     /locus_tag="GMA21_RS23200"
                     /old_locus_tag="GMA21_23200"
     CDS             3181..3912
                     /locus_tag="GMA21_RS23200"
                     /old_locus_tag="GMA21_23200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     gene            3919..4449
                     /locus_tag="GMA21_RS23205"
                     /old_locus_tag="GMA21_23205"
     CDS             3919..4449
                     /locus_tag="GMA21_RS23205"
                     /old_locus_tag="GMA21_23205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(4477..4656)
                     /locus_tag="GMA21_RS23210"
                     /old_locus_tag="GMA21_23210"
     CDS             complement(4477..4656)
                     /locus_tag="GMA21_RS23210"
                     /old_locus_tag="GMA21_23210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            4725..5102
                     /locus_tag="GMA21_RS23215"
                     /old_locus_tag="GMA21_23215"
     CDS             4725..5102
                     /locus_tag="GMA21_RS23215"
                     /old_locus_tag="GMA21_23215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            complement(5164..5463)
                     /locus_tag="GMA21_RS23220"
                     /old_locus_tag="GMA21_23220"
     CDS             complement(5164..5463)
                     /locus_tag="GMA21_RS23220"
                     /old_locus_tag="GMA21_23220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001146176.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(5453..5716)
                     /locus_tag="GMA21_RS23225"
                     /old_locus_tag="GMA21_23225"
     CDS             complement(5453..5716)
                     /locus_tag="GMA21_RS23225"
                     /old_locus_tag="GMA21_23225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     gene            complement(6022..>6174)
                     /locus_tag="GMA21_RS23230"
                     /old_locus_tag="GMA21_23230"
                     /pseudo=""
     CDS             complement(6022..>6174)
                     /locus_tag="GMA21_RS23230"
                     /old_locus_tag="GMA21_23230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /name="Exc2 family lipoprotein"
     gene            complement(6208..9213)
                     /locus_tag="GMA21_RS23235"
                     /old_locus_tag="GMA21_23235"
     CDS             complement(6208..9213)
                     /locus_tag="GMA21_RS23235"
                     /old_locus_tag="GMA21_23235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032495017.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn3 family transposase"
                     /protein_id="WP_155961103.1"
                     /translation="MPVDFLTTEQTESYGRFTGEPDELQLARYFHLDEADKEFIGKSRG
                     DHNRLGIALQIGCVRFLGTFLTDMNYIPSGVRHFTARQLGIRDITVLAEYGQRENTRRE
                     HAALIRQHYQYREFAWPWTFRLTRLLYTRSWISNERPGLLFDLATGWLMQHRIILPGAT
                     TLTRLISEVREKATLRLWNKLALIPSAEQRSQLEMLLGPTDCSRLSLLESLKKGPVTIS
                     GPAFNEAIERWKTLNDFGLHAENLSTLPAVRLKNLARYAGMTSVFNIARMSPQKRMAVL
                     VAFVLAWETLALDDALDVLDAMLAVIIRDARKIGQKKRLRSLKDLDKSALALASACSYL
                     LKEETPDESIRAEVFSYIPRQKLAEIITLVREIARPSDDNFHEEMVEQYGRVRRFLPHL
                     LNTVKFSSAPAGVTTLNACDYLSREFSSRRQFFDDAPTEIISRSWKRLVINKEKHITRR
                     GYTLCFLSKLQDSLRRRDVYVTGSNRWGDPRARLLQGADWQANRIKVYRSLGHPTDPQE
                     AIKSLGHQLDSRYRQVAARLCENEAVELDVSGPKPRLTISPLASLDEPDSLKRLSKMIS
                     DLLPPVDLTELLLEINAHTGFADEFFHASEASARVDDLPVSISAVLMAEACNIGLEPLI
                     RSNVPALTRHRLNWTKANYLRAETITSANARLVDFQATLPLAQIWGGGEVASADGMRFV
                     TPVRTINAGPNRKYFGNNRGITWYNFVSDQYSGFHGIVIPGTLRDSIFVLEGLLEQETG
                     LNPTEIMTDTAGASELVFGLFWLLGYQFSPRLADAGASVFWRMDHDADYGVLNDIARGQ
                     SDPRKIVLQWDEMIRTAGSLKLGKVQASVLVRSLLKSERPSGLTQAIIEVGRINKTLYL
                     LNYIDDEDYRRRILTQLNRGESRHAVARAICHGQKGEIRKRYTDGQEDQLGALGLVTNA
                     VVLWNTIYMQAALDHLRAQGETLNDEDIARLSPLCHGHINMLGHYSFTLAELVTKGHLR
                     PLKEASEAENVA"
                     /name="Tn3-like element Tn3 family transposase"
     gene            9377..9934
                     /locus_tag="GMA21_RS23240"
                     /old_locus_tag="GMA21_23240"
     CDS             9377..9934
                     /locus_tag="GMA21_RS23240"
                     /old_locus_tag="GMA21_23240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221001.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001235713.1"
                     /translation="MRLFGYARVSTSQQSLDLQVRALKDAGVKANRIFTDKASGSSTDR
                     EGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVAVRFIDDGISTDGDMG
                     QMVVTILSAVAQAERRRILERTNEGRQEAKLKGIKFGRRRTVDRNVVLTLHQKGTGATE
                     IAHQLSIARSTVYKILEDERAS"
                     /name="recombinase family protein"
     gene            10117..10977
                     /locus_tag="GMA21_RS23245"
                     /old_locus_tag="GMA21_23245"
     CDS             10117..10977
                     /locus_tag="GMA21_RS23245"
                     /old_locus_tag="GMA21_23245"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032489893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="broad-spectrum class A beta-lactamase TEM-1"
                     /protein_id="WP_000027057.1"
                     /translation="MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYI
                     ELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYS
                     PVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRW
                     EPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSA
                     LPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGAS
                     LIKHW"
                     /name="broad-spectrum class A beta-lactamase TEM-1"
     gene            11236..11712
                     /locus_tag="GMA21_RS23250"
                     /old_locus_tag="GMA21_23250"
     CDS             11236..11712
                     /locus_tag="GMA21_RS23250"
                     /old_locus_tag="GMA21_23250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016943399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="WbuC family cupin fold metalloprotein"
                     /protein_id="WP_013023839.1"
                     /translation="MKQITMSDMQQQSAAAVQSPRLRAHRNFHPELSDSVQRLAIAMEP
                     GTYVRPHRHPHTFELLLPLRGRFVVLNFDDRGTVTHRAILGETCTVLEMAAGTWHAVLS
                     LDTGGIIFEVKHGGYQPVAADDYAHWAPAEGEPGTTELMAWYAQAQVGDSTFAV"
                     /name="WbuC family cupin fold metalloprotein"
     gene            complement(11759..12634)
                     /locus_tag="GMA21_RS23255"
                     /old_locus_tag="GMA21_23255"
     CDS             complement(11759..12634)
                     /locus_tag="GMA21_RS23255"
                     /old_locus_tag="GMA21_23255"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011091028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extended-spectrum class A beta-lactamase CTX-M-3"
                     /protein_id="WP_011091028.1"
                     /translation="MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSG
                     GRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSD
                     LVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETF
                     RLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAA
                     SIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLA
                     SAAKIVTDGL"
                     /name="extended-spectrum class A beta-lactamase CTX-M-3"
     gene            complement(12969..>13163)
                     /locus_tag="GMA21_RS23260"
                     /old_locus_tag="GMA21_23260"
                     /pseudo=""
     CDS             complement(12969..>13163)
                     /locus_tag="GMA21_RS23260"
                     /old_locus_tag="GMA21_23260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_031587700.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /name="transposase"
     gene            13220..13917
                     /locus_tag="GMA21_RS23265"
                     /old_locus_tag="GMA21_23265"
     CDS             join(13220..13469,13469..13917)
                     /locus_tag="GMA21_RS23265"
                     /old_locus_tag="GMA21_23265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558270.1"
                     /ribosomal_slippage=""
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1 family transposase"
                     /protein_id="WP_223216367.1"
                     /translation="MASISISCPSCSATEGVVRNGKSTAGHQRYLCSHCRKTWQLQFTY
                     TASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTILRHFKKLRPQSVTSRIQPGSDVIV
                     CAEMDEQWGYVGAKSRQRWLFYAYDRIRRTVVAHVFGERTLATLERLLSLLSAFEVVVW
                     MTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVI
                     GHYLNIKHYQ"
                     /name="IS1 family transposase"
     gene            complement(<13933..14838)
                     /locus_tag="GMA21_RS23270"
                     /old_locus_tag="GMA21_23270"
                     /pseudo=""
     CDS             complement(<13933..14838)
                     /locus_tag="GMA21_RS23270"
                     /old_locus_tag="GMA21_23270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_031587700.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS1380-like element ISEcp1 family transposase"
                     /name="IS1380-like element ISEcp1 family transposase"
     gene            <15077..15819
                     /locus_tag="GMA21_RS23275"
                     /old_locus_tag="GMA21_23275"
                     /pseudo=""
     CDS             <15077..15819
                     /locus_tag="GMA21_RS23275"
                     /old_locus_tag="GMA21_23275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001493761.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="ISKra4 family transposase"
                     /name="ISKra4 family transposase"
     gene            <15852..16280
                     /locus_tag="GMA21_RS23280"
                     /old_locus_tag="GMA21_23280"
                     /pseudo=""
     CDS             <15852..16280
                     /locus_tag="GMA21_RS23280"
                     /old_locus_tag="GMA21_23280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017412822.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /name="recombinase family protein"
     gene            complement(16599..17255)
                     /locus_tag="GMA21_RS23285"
                     /old_locus_tag="GMA21_23285"
     CDS             complement(16599..17255)
                     /locus_tag="GMA21_RS23285"
                     /old_locus_tag="GMA21_23285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001516695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quinolone resistance pentapeptide repeat protein
                     QnrS1"
                     /protein_id="WP_001516695.1"
                     /translation="METYNHTYRHHNFSHKDLSDLTFTACTFIRSDFRRANLRDTTFVN
                     CKFIEQGDIEGCHFDVADLRDASFQQCQLAMANFSNANCYGIEFRACDLKGANFSRTNF
                     AHQVSNRMYFCSAFISGCNLSYANMERVCLEKCELFENRWIGTNLAGASLKESDLSRGV
                     FSEDVWGQFSLQGANLCHAELDGLDPRKVDTSGIKIAAWQQELILEALGIVVYPD"
                     /name="quinolone resistance pentapeptide repeat protein
                     QnrS1"
     gene            complement(17537..18928)
                     /locus_tag="GMA21_RS23290"
                     /old_locus_tag="GMA21_23290"
     CDS             complement(17537..18928)
                     /locus_tag="GMA21_RS23290"
                     /old_locus_tag="GMA21_23290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001493761.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISKra4-like element ISKpn19 family transposase"
                     /protein_id="WP_001493761.1"
                     /translation="MQLTLQIVITDESGSSRTEELMTIQKSGETRNDIGLSVSESKLLL
                     NTVQQSVVQLQADEYTQHHIRCPHCLAARRIKGKQKIRYRTLFGVIPVSGLRVYRCRCE
                     ESDTKTVSLLSDWAGDYSHPALKYIETRWASMISYEMTTRLLKDILPVGHSLNASTVRN
                     HLCQVAQRLDAEAEAHSGFLSGCPRDWGNLPRPGKPLVVGIDGGYVRDRDDKKRNFEII
                     AGKSFSVGAPADTRRFGFVQKDDCHPERRLMTHLSAQGMQANQQIFFLSDGADNLRDLQ
                     FGMYPESTHVLDWFHITMRLKVLMQYARGLLVSDPEAGSKVLALLESIKRYLWHGNVVA
                     ALEHIDNCVMYCDDPELSYPSLKSLQKHLDEMYTYIRNNKMMIPNYGEMRRYGEPVSTA
                     FVESTINEVIARRMAKKQQMQWSRKGAHYLLQTRTAVLNNELQDKFVCWYPGFQSDGKG
                     PAMAA"
                     /name="ISKra4-like element ISKpn19 family transposase"
     gene            complement(18965..19537)
                     /locus_tag="GMA21_RS23295"
                     /old_locus_tag="GMA21_23295"
     CDS             complement(18965..19537)
                     /locus_tag="GMA21_RS23295"
                     /old_locus_tag="GMA21_23295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001493762.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001493762.1"
                     /translation="MQYAYIRVSSADQNTARQEEALSKAGFQPDKICVEHASAKDTNRP
                     GLQELLGQLRPGDTLLVHSIDRLCRNMSDMCAVTTRLRDQGVTLIFLKEQLTFSAGTNN
                     PMQELQLHMMSAFSQFERALLKERQADGIAAKKARGEKTGRPGADIKKIQEIDALRSRG
                     VRLRIACDHAGLGVSTYYKLRHQMNNQ"
                     /name="recombinase family protein"
     gene            complement(19674..20219)
                     /locus_tag="GMA21_RS23300"
                     /old_locus_tag="GMA21_23300"
     CDS             complement(19674..20219)
                     /locus_tag="GMA21_RS23300"
                     /old_locus_tag="GMA21_23300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001493763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid pRiA4b ORF-3 family protein"
                     /protein_id="WP_001493763.1"
                     /translation="MVWRRLRIAADTSLAALHFIFQIVQGWGDDHLHQFHIYGKDYGIS
                     YEGGIGFVDNPFRVVIDDFAFDAGDRFTYEYNFFEHWLHDIRVEAIYENSTLKAPFCIS
                     GHGMPGATAADEFDKTLAFLEAIVNADDETTVGEIRPFADDLDAVRFNRHKINRQLSRL
                     DLASPVLEPEVIWLGRRR"
                     /name="plasmid pRiA4b ORF-3 family protein"
     gene            20414..20890
                     /locus_tag="GMA21_RS23305"
                     /old_locus_tag="GMA21_23305"
     CDS             20414..20890
                     /locus_tag="GMA21_RS23305"
                     /old_locus_tag="GMA21_23305"
                     /inference="COORDINATES: protein motif:HMM:NF023227.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4113 domain-containing protein"
                     /protein_id="WP_194164765.1"
                     /translation="MAITGFAARAGEKLRQEKQHCRAISVFIRTSPFSPRDAPCASQAT
                     ETLLVATQDSRDIIAAAQRALARIWRDGYRYAKAGIMLADFSGREAQLNLFDECAPRPD
                     SEALMNAVDRINRAGKGRIFFAGQGINVGFAMRREMLSPEYTTDWNALPRAFMR"
                     /name="DUF4113 domain-containing protein"
     gene            complement(21037..21318)
                     /locus_tag="GMA21_RS23310"
                     /old_locus_tag="GMA21_23310"
     CDS             complement(21037..21318)
                     /locus_tag="GMA21_RS23310"
                     /old_locus_tag="GMA21_23310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019077272.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000780222.1"
                     /translation="MKLVSHKELHNEWMQDDEYRAAWQEEERKEKLRELLAEWRKHDNL
                     TKAQVAERMGVTPPVISRLENNITKASIDTLTRYAHACGIKKPVIALY"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(21299..21628)
                     /locus_tag="GMA21_RS23315"
                     /old_locus_tag="GMA21_23315"
     CDS             complement(21299..21628)
                     /locus_tag="GMA21_RS23315"
                     /old_locus_tag="GMA21_23315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001647051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_000493286.1"
                     /translation="MFSVVYHPEAREEATALPVKIRVKFDRLIGKLEYDARLLREPDTK
                     PLGDGLFEIRTMGTDIARGIWVYHKGNTIIMLRVFIKKSQKTPAKEIDLAKKRLAEVLN
                     ETGKP"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            21864..22121
                     /locus_tag="GMA21_RS23320"
                     /old_locus_tag="GMA21_23320"
     CDS             21864..22121
                     /locus_tag="GMA21_RS23320"
                     /old_locus_tag="GMA21_23320"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_048337415.1"
                     /translation="MKVNYLAPLLCIGVLALTGCNDPKKPSESNFKEAAQQYLDTVYPA
                     CYIKANFPYKTDGFNINNMPEILHAMAEKGLLTETALLQS"
                     /name="hypothetical protein"
     gene            complement(22155..22859)
                     /locus_tag="GMA21_RS23325"
                     /old_locus_tag="GMA21_23325"
     CDS             complement(22155..22859)
                     /locus_tag="GMA21_RS23325"
                     /old_locus_tag="GMA21_23325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221000.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS26 family transposase"
                     /protein_id="WP_001067858.1"
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIINATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="IS6-like element IS26 family transposase"
     gene            complement(<22964..23233)
                     /locus_tag="GMA21_RS23330"
                     /old_locus_tag="GMA21_23330"
                     /pseudo=""
     CDS             complement(<22964..23233)
                     /locus_tag="GMA21_RS23330"
                     /old_locus_tag="GMA21_23330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /name="Exc2 family lipoprotein"
     gene            23636..25321
                     /locus_tag="GMA21_RS23335"
                     /old_locus_tag="GMA21_23335"
     CDS             23636..25321
                     /locus_tag="GMA21_RS23335"
                     /old_locus_tag="GMA21_23335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_004178188.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            25331..25588
                     /locus_tag="GMA21_RS23340"
                     /old_locus_tag="GMA21_23340"
     CDS             25331..25588
                     /locus_tag="GMA21_RS23340"
                     /old_locus_tag="GMA21_23340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            25673..25822
                     /locus_tag="GMA21_RS23345"
                     /old_locus_tag="GMA21_23345"
     CDS             25673..25822
                     /locus_tag="GMA21_RS23345"
                     /old_locus_tag="GMA21_23345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     ARG             complement(16603..17255)
                     /name="qnrS1"
                     /gene="qnrS1"
                     /gene_name="quinolone resistance pentapeptide repeat
                     protein QnrS1"
                     /tool="amrfinderplus"
                     /drug_class="QUINOLONE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(11763..12634)
                     /name="blaCTX-M-3"
                     /gene="blaCTX-M-3"
                     /gene_name="extended-spectrum class A beta-lactamase
                     CTX-M-3"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             10118..10974
                     /name="blaTEM-1"
                     /gene="blaTEM-1"
                     /gene_name="broad-spectrum class A beta-lactamase TEM-1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     BGC             18636..26086
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(2..418)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="93.571"
                     /coverage="100.0"
                     /evalue="2.36e-176"
     Typing          3182..3909
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.3599999999999998e-150"
ORIGIN
        1 gtggcgtttt gcgtgctttt ccgggttgga ctcaagtgaa cagttaccgg ataaggcgca
       61 gcagtcgggc tgaacggggg gttcttgctt acagcccagc ttggagcgaa cgacctacac
      121 cgagccgaga taccagagtg tgagctatga gaaagcgcca cacttcccgc aagggagaaa
      181 ggcggaacag gtatccggga aacggcaggg ttggaacagg agagcgcaag agggagcgat
      241 tcatcggaaa cggtgatgat ctttaagtcc tgtcgggttt cgccactcct gactgattca
      301 tggttgagcc accggctccc acagatgcac cgaaaaagcg tctgtttatg tgaactcagt
      361 caggagggcg gagcctatgg aaaaacgcca cctgcgtggc cttgccgttt tgcctcacat
      421 gttagtcccc tgcttattca cggaatctgt gggtaacttt gcatgtgtcc gcagcgcccg
      481 ccgcagtctc acggccggag cgtagcgacc gagtgagcga ggaggcgcaa tttccccggc
      541 acctacaaga cggacaccgg acgcgctgat gtggcatatt gtcccctgat taagtcttta
      601 tattccctga taataaatta ccaggatagg tgaatcatat cggtttttcg ctgaacattt
      661 tacgttaacc tatctctgtt gcttttttct ccttacggag aaatacaggt catccccgcg
      721 agggcgtggc tgacctcagg gggatatccc ctgcttacgc tggctggacg ccaccgacgc
      781 acggtctctc cccctctttc tggctccgtc cggctggacg ccggccacgc cagaaattca
      841 cccggccccc gtcaggctca cgcctgacca cccacaaaaa tccacggtgc tggacgcacc
      901 tggcgaagca gcaaagctgc tcctgatttt gcgggtggtc agccgctcgc tatggcgaac
      961 tctgacgggg gccggaacac cggaaaagac cgcactgggg tgccgccttt tcctctcaca
     1021 cgctggggcg tgctcgttgt tcctccgggg ctgcgccttt tccgcatggg gcggaaagag
     1081 gctggcctcc gtggtgaaag ctgaacgcaa tcaccacgga cgtgaccgcc gccgccatgc
     1141 cttggggcat gtccgcggct tgtgcagcgg gggctgcaca tcacgccggc aaaccatcgt
     1201 ctgaaggaga gagaacatgt ttaatacgga ttcgcttgcc tggaagtggc acattccgga
     1261 gctggcccgg cagatttatc cgtgggtcag ctggctgtac caggagtatt acggtctggc
     1321 cggggctttc ctagttatcg gcctgttttt cggtctggct gaactttggg ccggacggat
     1381 gcgttttgtg gggctgagtc ataaggagcg acgggagtat gccgatcgct ataagcgcga
     1441 taataaacgg ccagcgccat tttcggtgct ggcctcgctg gattcgcccg ggcggatggt
     1501 cagggcacgt cgacatgtct ggaactacgc gtactggctg accggcgcgg ccggtctggc
     1561 ccttctgggg gggctggttg tcgccgtgtt tatcgagagc tggggagaaa ccgtcctgcg
     1621 tccggacctc tacgcaaacg cagattatta cctgctgcag ccggctaacc tgttcgggat
     1681 tgcctggtgc gcgggcgggc tggctgtcgg gattgtgttg gcgcggctgc tggcgttcct
     1741 gctgcttgac ggtcattttg cggctgctga cgaggcggtg aacgcgaaac tgaatcagga
     1801 gagccggcgc agcagccagc ggacaggaga gatgaccgac gtgcgccacc tgcatttcgg
     1861 ggagccggta ccggttaatg cgctggccga tttttcctcg gagcaggccc ggcaggagca
     1921 ggcggtgttt ctgggtaagg atgagcaggg caagccggtg ctggttccgc gtgatacctg
     1981 gcgcaagacc aacattcaga tcctcggcct gcccgggagc ggcaagagcg tgatggccac
     2041 caacgcgctc attcgctgcg tacgcgattt cggggacgcg gtggtgtact tcgaccccaa
     2101 aggggacgca tgggcgccgc acgtcttccg ggcgcactgt ccggacttca ccctgctgga
     2161 tctgcggccg gggaaaccgg cgcagctgaa tctgttccgc gatctcgacc agtacgcgct
     2221 gaaaaacctg ctgattgccg ggcttaacct gggcgagacc ggcgacgtgg cggaccacta
     2281 ccgcatcagc gagcagaaag cggcgaagct gattgcggag cagtttccgc agggggcaaa
     2341 cattcagcag gtgctggcgg cggcgtacgc gctgccggag gccctgaaaa aggacgtgaa
     2401 ggggttgatc actaggctgg aaaacgtcgc tgacctgagc gtcctgcaga cggacagtgg
     2461 catcgatgtg gcggggatta tcaacggcgg cggctgcctg tacgttatcg gctcgatgga
     2521 cgacgaggcg gtgatccgtg tgcaaaaaat gctgtttgcc cgctgcgcgc aaatcatcat
     2581 tgcgcgggac gagttccggg agtggccaca cgtcagcgtg atgctcgatg aaattaaata
     2641 tctgctgtcg aagtatgtac tgaacgcact ggggacgctg cgcagccggg actgcaatct
     2701 gttgctcgcg caccagtcgc tgggcgattt cgggcagtgc gggcaggatc tgcccgctga
     2761 atttgtgaaa accacggtac tggataacac gccgatccgc tggttttacc gggcggccag
     2821 cctggagtcc gcgcagtggg cggcggggca gaccggggaa atcagggtgg acgtggagcg
     2881 ccgccgtgcc agccgggagg cggggaacgt ggagcatatc agcggggaca gcttcatcca
     2941 gaaggaggcg cggccgctgt ttgacgtgaa caccctgcaa cacctgccgg acgggttcgc
     3001 ggtcatgacc gggctgggtg tggcccggat ggcgttcagc agtccgctgc gggttgagcg
     3061 ccgggaaatc ccgttgcagc gtttcccggt gctggcgaaa accgatcccc tggcggagtt
     3121 ccggcccccg gccgacggcg gcgggccgaa agcggatgat gattttgcgg ggatttactg
     3181 atggcgctgg agctgtacaa cgtcagccac gcgaaacgac aggcgcggaa cgcggagaaa
     3241 acccggctga ccctgcgctg gttgcgggaa gagctgtgtt ccacggcgga gctggttgcg
     3301 cggcggctgg ggattgcggc ggtgcagccg gtctaccgct tcctcgacag cctggtggcg
     3361 aaagggctgc tggtccggac caaatatccg gtggacggcc gtcaggtcag cgtgtggggg
     3421 ctgacgccgc atggcgtggc gttctcgttc gacgaggacg aaccgctggc ggatgttatt
     3481 ccgtttcagc cgtcaagggt gtcggcagca catctgccgc accggctggc cgtgcaatcc
     3541 ctgcgccttg atatggaagc cagaggggcc accggctggc gcattctgca ccgtctgagt
     3601 cttaaaggca tgaaagtgcc ggacgccctg gcggagctgg acggtaaaac ggtggcgttt
     3661 gaggtggagc gcaccgtcaa gagccgtcgc cggtatcagg aagtggtgtc cgggtatctg
     3721 ttcaaccgca aagctaacgg catcgatgaa atctggtaca tctgcccgga ccgggcgacg
     3781 caggtcaggg tgcagcgggc aatcctgtcg gtggatgaaa tcgtgaaccc acagaccggc
     3841 gaggcccgca aaacggcaga gctggatcgt gaacggttgt ttgcgtgctt taaatttatg
     3901 acaacggagt gagggattat ggcgctgtac atggtattta ttgaagacgc ggaggaccgg
     3961 aacggcgagc gctgcatcat gccgaccagc gagcatctgg aagatatggt ggtgctcgcc
     4021 tggcagaccg gggcgtatgt tttctgtttt gtcgaccggg cccagcatct ggcgatgatg
     4081 aaatccatcg ggatgtatga cgagcggctc aacagcgacg aaaaagccac gtactttttc
     4141 actggtaaaa atccgcaatg ggaacggaac aaacccacag gaatgaagct gtgtgattac
     4201 ctctatcgca aggtggagcg gttcgccatc gagaacggtg tgcaggtggt tgatgccggg
     4261 aagtgctcac cggagcagat taacgcgatg attgacgtgg tgagtgagcg gcacggggaa
     4321 agcgcggtga acgagaagct gaaagcggag ctgatgcggg aatataacag ccgctatttt
     4381 aacgtgccgg tacctgaact gccggaggac aaacctgccc gccggtggtg gccgttcggc
     4441 aaaaaataaa tgccagcacc ggccatgccg gtgctgttat tcctccccga gcttatcccg
     4501 catcacctgc cagagtgttt ccgcatcctc gtgtagccgc tcgcacatgt cggccggggt
     4561 atccatatcc agctcattca gtttatcgag caatagcagc gactgctcct taataaattt
     4621 agccatattg agggctgttt tttcctgttt tgtcatgatt ctttccttcc gggcatggtg
     4681 tgcgcctgtc aggtatactg tctcaaaaat agcggggtga gacaatggcg tgggtgacgg
     4741 tgagacaggc gacggaactg acgggtaaag cccgaagttc cctgtatcgg gatatggcga
     4801 aaggccgcgt atcataccgt acggaagctg atggcggccg ggtggtggat accagcgagc
     4861 ttatccgggt gtacggtgag ttaagacagg atgagactca cgagcgggac gagttgagac
     4921 tgtcgggtga gactgaaaaa atggcctccg acgcgttgat cgcggagata aaagcactca
     4981 gggaggaggt ggccgggcta cggcaggaaa tgcagtccat gagactgctg gaacacaaac
     5041 cggagacagc agagaccccg gccggaacac cgcgccggtg gtggccgtgg ggaaaacgct
     5101 gacgcgctgt gcttgtccaa ccggcgacgg ccacgcaatg aattgcgtcc ccgtcaccgg
     5161 ttattagaga acaatatggg gattctggcg ctggccgacc acggccagaa cccggacttt
     5221 tctggtctgg tcatcaacat catagaggac atgctgtccc atcagactga tccggcgaac
     5281 gtcctcgcca tagcgtgagt ccacttcata gagtcgcggg aagtcggcca gtttgtccgc
     5341 cgcagcgaga acccggtcgg taacgttctg cgcatcccac agggatgaat tttccgcgat
     5401 atagtcaaac agcgtcgtta catcctcgat ggctccctgc ttccattcca cgtcatacgg
     5461 catcgcgcag ttcctgataa cggccatgca ggcgctggcg gagttgttcc gtggtcatac
     5521 ccggacgcgt gtcagcacgg gcggcggtca ctttggcgcg aacctgatct tcatactctg
     5581 cctgggccag ttcttcgtta gccagtcgct gcaacagcgc agctttgtcc gggccacctt
     5641 ccggcagtat gcggggcagg ctttcagcca gttcccgaag aaagttggcg ttttcgtagt
     5701 gtgtagtgtt gctcattgcg gagcctcccg ggttaatgcg gcaatatgaa ggaagtttag
     5761 cagggggcgg tctgaaagaa tatggtcgtg tcagtcaggc tgatgaagca gaaagtcggt
     5821 aaaaaagggc ttacggcatc cattttacgt caaaacatat gccatgcagt tgcgtgcata
     5881 ggcatgcatt aggataaaat ttatcgggcg cgtttccggc agttttccgg gggggttgtt
     5941 gcctgtttta tcccgtagcc gccggaaacg ccctgagccc gtctgagcgg tgcgcgtaat
     6001 gacgcgttat ggtaaatcca cttactgtct gccttcatag ccatcgagat aaacagctga
     6061 aatggtgtca gccagtagcc ttgatttttt cggtgtgagg tctttgctgc ggtaatcggt
     6121 acccgcaaat tgtgttgtgc cttggagtga gtttaaaaat tcctgactgt gaaaggggtc
     6181 tgacgctcag tggaacgaaa actcacgtta agcaacgttt tctgcctctg acgcctcttt
     6241 taatggtctc agatgtcctt tggtcaccag ttctgccagc gtgaaggaat aatggccgag
     6301 catattgata tgtccgtggc aaagcgggga gaggcgtgcg atatcttcat cattcagtgt
     6361 ttcaccctgc gcccggagat gatccagggc tgcctgcata taaatagtgt tccataacac
     6421 gacggcgtta gtgaccagcc ccagtgcgcc cagttgatct tcctgaccgt cggtatatcg
     6481 ttttcttatc tcaccttttt gaccgtgaca gatggctctg gcaacggcat ggcgactttc
     6541 tccccgatta agctgggtca gaatgcgccg gcggtaatct tcatcatcaa tataattaag
     6601 cagatacagc gttttgttga tgcgccccac ttcaatgatt gcctgagtca gtccggaagg
     6661 acgttcactt ttcagcaatg aacggaccag cactgaagcc tgtactttgc ccagcttcag
     6721 ggagccagcg gtccggatca tttcgtccca ctgaaggact atttttcggg gatctgattg
     6781 ccctctggca atatcattca gcacgccata gtcggcatca tggtccattc gccagaaaac
     6841 cgaagcaccg gcatcagcca ggcgtggaga aaactggtat cccagcagcc agaaaaggcc
     6901 aaagacaagt tcgctggcac ctgctgtatc ggtcataatt tcggttggat tcagcccggt
     6961 ctcctgttcc agaagacctt ccagcacaaa gatagagtcc ctcagcgtcc ccggtataac
     7021 gatgccatga aagccggaat actgatcgga cacaaagttg taccaggtga tccctctgtt
     7081 attaccaaag tatttgcggt tcggtccggc attgattgtt ctgactggcg taacaaagcg
     7141 cattccatct gcagatgcca cttctcctcc accccatatc tgtgccagtg gcagcgttgc
     7201 ctgaaaatca accagtctgg cattagcgct ggtgatagtt tcagcccgca gatagttcgc
     7261 ttttgtccag ttcagccggt gtcgggtcag tgcaggaaca tttgatctga tcagtggttc
     7321 cagaccgata ttgcaggctt cagccatcag cacggcgctg atgctgacgg gcagatcatc
     7381 aactctggca ctggcttcac tagcatggaa aaactcatca gcaaatccgg tatgggcgtt
     7441 aatttcgagc agcaactccg ttaaatccac cggagggagt agatcactga tcattttgct
     7501 cagtcgtttc agactgtccg gctcatcaag actggcgagg ggagaaattg tcaaccgggg
     7561 cttcgggcca gaaacatcga gttcgacagc ctcattttcg caaagacgtg cagcaacctg
     7621 tctgtaacga ctatcaagct gatgacccag agattttatt gcttcctgcg ggtctgtcgg
     7681 gtgccccaaa gaacgataaa ccttaatccg gtttgcctgc cagtcagcac cctgtagtaa
     7741 tcttgcacga ggatctcccc accggttact gccggtaacg tagacatccc tccgcctcag
     7801 actatcctgc agtttactga gaaagcagag cgtgtatccc ctgcgggtga tatgtttttc
     7861 cttgttaatc accagccgtt tccatgaccg actgataatt tccgttggtg cgtcgtcaaa
     7921 aaactgccgc cgtgagctga actcccggct gaggtagtca caggcattca gagtggtaac
     7981 cccggcaggt gcggatgaaa atttaacggt attcagcaga tggggcagga aacgacgaac
     8041 gcgcccgtac tgctccacca tttcttcatg aaaattatcg tctgagggcc gggcaatttc
     8101 acggacaagc gtgatgattt cagccagctt ttgccttggg atgtagctga acacctcagc
     8161 acgaatcgat tcgtccggtg tttcttcttt cagcaggtac gaacatgcgc tggcgagcgc
     8221 caatgcagat ttatccagat ccttcagcga gcggagccgt tttttctgcc caatctttct
     8281 ggcgtcacgg atgataacgg ccagcatggc gtccagaacg tccaatgcat catccagcgc
     8341 cagcgtttcc catgcaagga caaaggcaac cagaaccgcc atccttttct gcggtgacat
     8401 cctggcaata ttgaacaccg aagtcatacc agcataacgt gcgagatttt tcaggcgcac
     8461 agccgggagt gtactcaggt tttcagcatg caggccaaaa tcgttcagag ttttccagcg
     8521 ttcaattgct tcattaaacg ccggaccact gatggtcaca gggccctttt tcagtgattc
     8581 cagtaaagac aggcggctgc aatcagttgg ccccagcagc atctccagct gtgaacgctg
     8641 ttcggctgac ggtatcagtg ccagtttgtt ccacaggcgc aacgtcgcct tttcccttac
     8701 ctctgaaatc aaccgggtca gcgtagtggc tccggggaga ataatacgat gttgcataag
     8761 ccaccctgtc gccagatcga aaagcaggcc aggacgttcg ttgcttatcc agctccgggt
     8821 atataaaaga cgggtaaggc gaaatgtcca gggccaggca aattcacgat actgatagtg
     8881 ctgacgtatc agcgctgcat gctcacggcg ggtattttcc ctctgaccgt attctgcaag
     8941 aacggtgata tcacgaatcc cgagctgtct ggcggtaaaa tgccggacgc cggaaggaat
     9001 ataattcata tcggtgagga aggtgcccag aaaacggaca catccaattt gcagggcaat
     9061 gcccagacgg ttgtgatcac ctctgctttt tccgataaat tccttgtctg cttcatcaag
     9121 gtgaaaatat cgtgccagct gaagctcatc cggttcaccg gtgaatctgc catagctttc
     9181 agtctgctca gtggtcagaa agtcaacggg catatcggcc tccctgcctg acgggcattt
     9241 agtaacattt ttccaaccgt acgaaatgtt ataaattatc ggacatcgta aaactgttac
     9301 attaatatgt ctattaaatc gtaaatttgt aataatagac atgagttgtc cgatattcga
     9361 tttaaggtac atttttatgc gactttttgg ttacgctcgg gtctcaacca gtcagcagtc
     9421 tcttgatctt caggtcagag cactcaaaga cgcaggtgtg aaagcaaacc gtatatttac
     9481 cgataaggca tccggcagtt caacagaccg ggaagggctg gatttgctga ggatgaaggt
     9541 ggaggaaggt gatgtcattc tggttaagaa gctcgaccgt cttggccgcg acactgccga
     9601 tatgatccaa ctgataaagg aatttgacgc tcagggcgtg gcagtccggt tcattgatga
     9661 cgggatcagt accgacggtg atatggggca aatggtggtc accatcctgt cggctgtggc
     9721 acaggctgaa cgccggagga tcctagaacg cacgaatgag ggccgacagg aagcaaagct
     9781 gaaaggaatc aaatttggcc gcaggcgtac cgtggacagg aacgtcgtgc tgacgcttca
     9841 tcagaagggc actggtgcaa cggaaattgc tcatcagctc agtattgccc gctccacggt
     9901 ttataaaatt cttgaagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc
     9961 atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc
    10021 cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc
    10081 tggtaaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca ttttcgtgtc
    10141 gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg
    10201 gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat
    10261 ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc
    10321 acttttaaag ttctgctatg tggtgcggta ttatcccgtg ttgacgccgg gcaagagcaa
    10381 ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa
    10441 aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt
    10501 gataacactg ctgccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct
    10561 tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat
    10621 gaagccatac caaacgacga gcgtgacacc acgatgcctg cagcaatggc aacaacgttg
    10681 cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg
    10741 atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt
    10801 attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg
    10861 ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg
    10921 gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg
    10981 tcagaccaag tttactcata ctgaaataat tggggggtga ttaccaccgt aaatttttcc
    11041 cagacggtaa aaagaattac agacttttat caactaaaaa agtggcctga atatcagcac
    11101 taccgtcaat accatttcag taaatcagga tagggaaaaa ttggcaaacc cagttcttca
    11161 cttgctctgc gggttctgtc accctgacgt catacggtaa tcccccccaa ttcattaatc
    11221 gacaaggtca tcctgatgaa acaaattacc atgagcgata tgcagcaaca gagcgcagcg
    11281 gctgtgcaat cgcctcggct ccgcgcgcac cgtaatttcc atccagaatt aagcgattcg
    11341 gtccaacgtc tggctattgc catggaacct gggacctacg tgcgcccgca ccgacaccct
    11401 cacaccttcg agctactgtt gccattaagg ggtcgtttcg tggtgctgaa ttttgacgat
    11461 cggggtaccg tcacccatcg ggcgatattg ggggaaacct gtacggtgct ggagatggcc
    11521 gcaggaacct ggcatgccgt gctgtcgctg gataccggtg gcataatttt tgaagtaaaa
    11581 cacggtggct atcaacccgt ggctgccgat gactatgcgc actgggctcc agcggaagga
    11641 gaaccaggaa ccacggagct tatggcctgg tatgcgcaag cgcaggtggg cgacagcact
    11701 tttgccgtct aaggcgataa acaaaaacgg aatgagtttc cccattccgt ttccgctatt
    11761 acaaaccgtc ggtgacgatt ttagccgccg acgctaatac atcgcgacgg ctttctgcct
    11821 taggttgagg ctgggtgaag taagtgacca gaatcagcgg cgcacgatct tttggccaga
    11881 tcaccgcgat atcgttggtg gtgccatagt caccgctgcc ggttttatcc cccacaaccc
    11941 aggaagcagg cagtccagcc tgaatgctcg ctgcaccggt ggtattgcct ttcatccatg
    12001 tcaccagctg cgcccgttgg ctgtcgccca atgctttacc cagcgtcaga ttccgcagag
    12061 tttgcgccat tgcccgaggt gaagtggtat cacgcggatc gcccggaatg gcggtgttta
    12121 acgtcggctc ggtacggtcg agacggaacg tttcgtctcc cagctgtcgg gcgaacgcgg
    12181 tgacgctagc cgggccgcca acgtgagcaa tcagcttatt catcgccacg ttatcgctgt
    12241 actgtagcgc ggccgcgcta agctcagcca gtgacatcgt cccattgacg tgcttttccg
    12301 caatcggatt atagttaaca aggtcagatt ttttgatctc aactcgctga tttaacagat
    12361 tcggttcgct ttcacttttc ttcagcaccg cggccgcggc catcacttta ctggtgctgc
    12421 acatcgcaaa gcgctcatca gcacgataaa gtatttgcga attatctgct gtgttaatca
    12481 atgccacacc cagtctgcct cccgactgcc gctctaattc ggcaagtttt tgctgtacgt
    12541 ccgccgtttg cgcatacagc ggcacacttc ctaacaacag cgtgacggtt gccgtcgcca
    12601 tcagcgtgaa ctggcgcagt gattttttaa ccatgggatt ccttattctg aaagagacga
    12661 aataacaaca acatgaatag tcaatatttt acctgaagcg agccacaacg cgtccgattt
    12721 tatgcttccg aaaggcaaat acggacgtcg ccagaatgaa acctaaattc cacgtgtgtt
    12781 ttttattagc ttcaaaaatc actatttcac gaagaattta gactgcttct cacacattgt
    12841 aacattattt acaaccacct ttcaatcatt tttgataaat cattgatttc atctttgctg
    12901 caatgatact taataaactc tgcaagttat ccacagagca acactcaatt ttattgatga
    12961 tattcttatt ataccagaca tttttcatac actcccttgt acggatagtt ttccgacaac
    13021 ttcatgatta catatcttgc ggttttgatt atttttgctg caagaaatac atacttcaaa
    13081 cgaaaggtct ttatttgctg tctgtattct gaagagtcca aggaatcaaa cttgaacaac
    13141 aaaaataggt tatatgaaag catcggtaat ggtgccaact tactgattta gtgtatgatg
    13201 gtgtttttga ggtgctcccg tggcttccat ctccatcagt tgtccctcct gctcagctac
    13261 tgaaggcgtg gtgcgtaacg gtaaaagtac tgccggacat cagcgctatc tctgctctca
    13321 ctgccgtaaa acatggcaac tgcagttcac ttacaccgct tctcaacccg gtacacacca
    13381 gaaaatcatt gatatggcca tgaatggtgt tggatgccgg gcaaccgccc gcattatggg
    13441 cgttggcctc aacacgattt tacgtcactt aaaaaactca ggccgcagtc ggtaacctcg
    13501 cgcatacagc cgggcagtga tgtgattgtc tgcgctgaaa tggacgaaca gtggggctac
    13561 gtcggtgcta aatcacgtca gcgctggctg ttttacgcgt atgacaggat acggaggacg
    13621 gttgtggcgc acgtcttcgg tgaacgcact ctggccacac tggagcgtct tctgagcctg
    13681 ctgtcggcct ttgaggtcgt ggtatggatg acggatggct ggccgctgta tgaatcccgc
    13741 ctgaagggaa agctgcacgt aatcagcaag cgttacactc agcgcattga gcgacataac
    13801 ctgaatctga gacaacatct ggcaaggctg ggacggaagt cactgtcgtt ctcaaaatcg
    13861 gtggagctgc atgacaaagt catcgggcat tatctgaaca taaaacacta tcagtaagtt
    13921 ggagtcatta ccaaagtagt cgtattcgga accttctaaa agtgataatt gtgctctttc
    13981 tttttctggt ttcagtacgc gagatacgac aaatcttctg tctttttccc atttaactaa
    14041 ttttgtatac agttctgtag tttctctacc ttcttctcct ttaacgaata caattgatga
    14101 attcgttgct tgtgaggtga gtgtagaata acttttggct ttaattaaat atttgcatcc
    14161 aagagattct atcgtttcga taattttttc atcaaagtag ccactatcca ttcgaaataa
    14221 aatttctaaa tcgtctgatt tgatgttagc aacaatttct ttgatcattt ccgcagcacc
    14281 gtttgcagtg taagtattgc cacttcttac aaatccggta acatatgctt ttaattcgtc
    14341 gcaaaatgca aattggatat tgtagcatcg gtttcccagt ttcttaggat tatatccttt
    14401 tgacgcacct tcttgatgac cttctacgtt aattacacta ctatcaatat caatcgtaat
    14461 ggatgtcaat ttacttttag tgagcagttt tttaaagact ttaaaattaa tgtctctaaa
    14521 catttgggtt gtcttgaagt tgaagtttcc tagaaaccgt gacactgttt caggttcttt
    14581 tacggaaata tcaaactcgt tgacgagggg atcattttga agtagcttta gacgttctaa
    14641 cttatcaatg ccaatgaagt gaccgcagag catggtcttt atatgattca tcttgatttt
    14701 atttgttgag tcattatcaa atacgaggtc attttcaata aaatcaaaaa tcccattgct
    14761 ttttgcattc tcaaggagca gaaaaagacc tgcatttgat gttagattct tagctttgaa
    14821 atcaatttta ttaatcataa ttagaacccc tttttactac ttttcttact attattttac
    14881 catatatcga gtcataaaag ctgataattt aacatatttt tgagcacttt tctttcaccc
    14941 aatgggtgaa agctgaattt cgaaggaatg catatttatc aaggctttga ttatgctttt
    15001 tgaagtactg acgtagaatc taggtcatat atactttaga ttgatttaaa acttcatttt
    15061 taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa
    15121 cgtgagtttt cgttccactg agcgtcagac cccaaggatg actgtcatcc ggaacgcagg
    15181 ctcatgaccc acctttcagc gcagggaatg caggccaacc agcagatatt ttttctgtcc
    15241 gacggcgcgg ataatctcag ggacctccag ttcggtatgt accctgagtc aacgcatgtg
    15301 ctggactggt ttcatatcac catgaggctg aaggtgctca tgcaatatgc ccggggactg
    15361 ctggtatcag atccagaggc ggggagtaaa gttctggcac tgctggaaag cattaaacga
    15421 tatctctggc atggcaatgt tgtcgctgcg ctggaacata ttgataattg cgttatgtat
    15481 tgcgatgacc ctgaactcag ctatcctagc ctgaaatccc tgcaaaaaca tctggatgaa
    15541 atgtatacct acatccggaa taataagatg atgatcccaa actacggcga aatgcgtcgg
    15601 tacggagagc cggtatcaac cgcgtttgtg gaatccacga tcaatgaagt gatcgccaga
    15661 cgaatggcca aaaagcagca gatgcagtgg agcagaaaag gggctcatta tttgttacag
    15721 acccggaccg ccgttttgaa taacgaactg caggataaat ttgtctgctg gtatccgggt
    15781 tttcaaagtg acgggaaggg accagcgatg gcagcatagc tcacgctgcc ccaatatttt
    15841 ttatgctctc ggtcgtatgg aagctggacc gcctcggtcg tgatcttcgt catctcatta
    15901 atacagtgca cgacctgacc gcgaggggga ccggtctgaa agtgctgacc ggtcacgggg
    15961 cgactatcga cacaacaacg gccgctggca agcttgtctt cggtatcttt gccgcactgg
    16021 cggagtttga gcgcgaactg attgctgaaa gaacgactgc aggtctggca tcagcaagag
    16081 cccgtgggcg gaacggcggc cgaccttata aaatgacgcc agtcaaactg cgactggcaa
    16141 tggcatcaat gggacaatca gaaacaaagg tcagtacgct atgccaggaa cttgggataa
    16201 cccggcaaac tttgtacagg catatttccc ctgttggtca actgcgggcg gacgggatca
    16261 agctgctcaa ccgtggataa tttgaacgga cggaaaaatc tggggttccg gcgtagtacc
    16321 cctatcacct ccacattttt gcaacagtgc cttataaatg gcagccttat gtttacttgc
    16381 caagatgggc taccatatga tgttttatac tgagcaatat taatattatc tttaatggaa
    16441 aaattaagcc cactaagtga cccactgcta tatggctcta ttgtgaagac gcctgagggt
    16501 aaaaatttat acatggttgt ccctatgtct attattgcaa ggttgacaat attattcgtt
    16561 ttataaattt gagcgtttaa aatcacacat caaagcaatt agtcaggata aacaacaata
    16621 cccagtgctt cgagaatcag ttcttgctgc caggctgcaa ttttgatacc tgatgtatcg
    16681 actttgcggg gatctaaacc gtcgagttcg gcgtggcata aattggcacc ctgtaggcta
    16741 aattgccccc agacatcttc ggaaaaaaca cctcgactta agtctgactc tttcagtgat
    16801 gcacccgcta ggttcgttcc tatccagcga ttttcaaaca actcacattt ttctaaacaa
    16861 accctctcca tattggcata ggaaagatta catccagaaa taaatgctga gcaaaagtac
    16921 atacgattac tcacttgatg ggcaaagttt gttcgggaaa agttggcacc ttttaaatca
    16981 cacgcacgga actctatacc gtagcaattg gcattactga agtttgccat cgcaagttgg
    17041 cattgttgga aacttgcatc acgaagatct gcgacatcaa agtggcagcc ttcgatatca
    17101 ccctgttcaa tgaacttgca gttgacgaat gtcgtatcac gcaagttagc acgtcgaaag
    17161 tcgctgcgaa tgaatgtgca agcggtgaag gtgagatcac ttaagtcttt atgtgaaaag
    17221 ttgtggtgcc gatatgtatg attgtaggtt tccatgagta ctccttgttg aaaggagggc
    17281 tagactacca ttatacatat gccaagacat taaaataaaa gcctgttaca tcaacacatt
    17341 acaacccctc aatttacctg ttttaagtgg tcaaattggc gcgtagagcg cctatcgctc
    17401 ttgcattggc acgcggccct gttgaaaaaa gttattcgct ttagataggg ttaggagagc
    17461 cgtgcttcgc cggtaaaaaa tcggactatc cgacgcaggg cggacgagag cataaaaaat
    17521 attggggcag cgtgagctat gctgccatcg ctggtccctt cccgtcactt tgaaaacccg
    17581 gataccagca gacaaattta tcctgcagtt cgttattcaa aacggcggtc cgggtctgta
    17641 acaaataatg agcccctttt ctgctccact gcatctgctg ctttttggcc attcgtctgg
    17701 cgatcacttc attgatcgtg gattccacaa acgcggttga taccggctct ccgtaccgac
    17761 gcatttcgcc gtagtttggg atcatcatct tattattccg gatgtaggta tacatttcat
    17821 ccagatgttt ttgcagggat ttcaggctag gatagctgag ttcagggtca tcgcaataca
    17881 taacgcaatt atcaatatgt tccagcgcag cgacaacatt gccatgccag agatatcgtt
    17941 taatgctttc cagcagtgcc agaactttac tccccgcctc tggatctgat accagcagtc
    18001 cccgggcata ttgcatgagc accttcagcc tcatggtgat atgaaaccag tccagcacat
    18061 gcgttgactc agggtacata ccgaactgga ggtccctgag attatccgcg ccgtcggaca
    18121 gaaaaaatat ctgctggttg gcctgcattc cctgcgctga aaggtgggtc atgagcctgc
    18181 gttccggatg acagtcatcc ttctgaacaa aaccgaagcg gcgggtgtca gcaggcgcac
    18241 caacggaaaa agacttcccg gcaataattt caaaattacg ctttttgtca tcccgatcgc
    18301 gaacataacc accatctata cccaccacaa gcggttttcc tggcctgggc aggttccccc
    18361 agtcgcgggg gcagccggaa agaaaacctg aatgagcttc agcctcagcg tcaagacgct
    18421 gcgccacctg gcataaatga ttcctcaccg ttgaggcatt caggctgtgg cccaccggca
    18481 gaatatcttt cagcagacga gtcgtcattt cataggagat catcgaggcc cagcgggttt
    18541 caatatattt cagtgccggg tgagaataat cgccggccca gtcgctgagc aaactgactg
    18601 tctttgtatc actctcttca caacggcacc ggtacacccg aagcccggat accggaataa
    18661 cgccaaacag cgtccggtac cgtattttct gtttgccttt gattctgcgc gcagcaaggc
    18721 agtgagggca ccggatatgg tgttgagtat attcgtctgc ctgcagctgg accaccgact
    18781 gctggaccgt attcagcaac agcttggatt ctgacaccga taatccgatg tcgttccggg
    18841 tctcccctga tttctggatt gtcatcagtt cctccgttcg actggagcct gattcatcgg
    18901 tgatgactat ctggagcgtc agttgcatca ttgcctcctg ctgtggtgga tgactatctc
    18961 ccggctactg gttgttcatc tggtgacgaa gcttataata tgtggaaacg ccaaggcccg
    19021 catggtcgca ggcgatcctg agcctgaccc ctctgcttct gagtgcgtca atttcctgga
    19081 tctttttgat atcggcgccg gggcgccctg ttttttcacc ccgtgctttt ttcgcggcga
    19141 tgccgtcggc ctgcctttcc ttcagtaagg ctcgttcaaa ctggctgaat gccgacatca
    19201 tgtgcagctg cagttcctgc atcggattgt ttgtgccggc gctgaacgtc agctgctctt
    19261 tcagaaaaat aagggtaacg ccctggtcac gaagccgggt ggtgacagcg cacatatccg
    19321 acatattccg gcaaaggcga tcgatggaat gaaccagaag cgtatcacca gggcgtaatt
    19381 gccccaggag ttcctgtaac cccgggcggt ttgtgtcctt cgcgctggca tgctcaacac
    19441 aaattttatc aggctgaaaa cccgcctttg acaatgcctc ttcctgacgg gccgtattct
    19501 gatcggccga gcttaccctg atgtaggcat attgcacgca aaacctccgg aaggtcttta
    19561 aacatcatag agatttaaag aataatccat aaacactgat ttagggaggt ttatagacat
    19621 tttttcgggg atctgagagg catgctgaaa acgtatacct ttatagacat cagtcagcga
    19681 cgacggccca gccagataac ttcaggctcc agtaccggag atgcaaggtc gagcctgctc
    19741 agttgccggt tgattttgtg gcggttgaac ctgacagcat ccaggtcgtc agcaaaaggg
    19801 cggatctcgc cgaccgttgt ttcatcatcc gcattaacga tagcttcaag aaacgccagg
    19861 gttttatcga actcatccgc agctgtggct ccgggcatac catggccgct tatacaaaac
    19921 ggcgctttca gcgtagagtt ttcataaatg gcctcaacac gaatgtcatg aagccagtgc
    19981 tcaaagaaat tgtattcata ggtaaagcga tcgccagcat caaaagcaaa atcatcaatc
    20041 acgacccgga acggattatc gacaaaaccg atgcctcctt cgtaggagat accgtaatct
    20101 ttgccataaa tgtgaaattg atggagatgg tcgtcccccc agccctgcac tatctggaaa
    20161 atgaagtgaa gcgcggccag tgacgtgtcg gcagcaattc tcagccgacg ccagaccatc
    20221 ggactgactc catgaactgc tattttgatg acgtagatct tcatagtcag caggtattgt
    20281 tatgaaatga tggtggttat tttaacccct gtagatggca tcattcgatg gctgccccga
    20341 ggtttttcat gctctccaaa ttgtcgtctc caggtcattt ggtgagcgtg taaccagctt
    20401 tcaggaaatg cagatggcca tcaccggctt tgctgcgcgg gcaggagaaa agctgcgtca
    20461 ggaaaagcag cactgtcgtg cgatcagtgt ctttatccga accagcccgt tttcaccccg
    20521 ggatgcgccc tgtgccagcc aggcgacgga gacgctactg gtagccactc aggacagccg
    20581 ggacatcatt gccgctgccc agcgtgcgct tgcgcgcatc tggcgtgatg gctaccggta
    20641 cgcaaaggct ggtatcatgc tggccgattt ttccggccgc gaggcacaac ttaatctgtt
    20701 tgatgaatgt gctccccgtc ctgacagcga agccctgatg aatgccgtcg atcggattaa
    20761 ccgcgccggt aagggccgca ttttttttgc cggccagggg atcaatgtgg ggttcgcgat
    20821 gcgcagggaa atgctgagtc cggaatacac gacagactgg aacgccttgc cgcgtgcttt
    20881 catgagataa gcgatatctg gattttatag atgtaaaatc atatggttac attattaacg
    20941 tatggttctt ccccattggg cttcagacct cctgtaccgc gttttcctgt tgagacaaca
    21001 cctacccggc gaaaactaaa accgggtagg atgtcatcag tacagggcaa tgacaggttt
    21061 tttgatgccg caggcgtgag cgtagcgggt cagagtgtcg atgctggctt tggtgatgtt
    21121 gttttccagg cgggaaataa ccggaggtgt aacccccatg cgttcagcaa cctgcgcttt
    21181 tgtcaggttg tcatgtttac gccattccgc aagtagctct ctgagcttct ccttgcgttc
    21241 ttcttcctgc catgcagcgc gatattcgtc gtcctgcatc cactcgttat gcagttcttt
    21301 atggcttacc agtttcatta agtacctccg ctaaccgctt tttggcgaga tcgatttctt
    21361 tcgctggcgt tttctgtgac ttcttgatga aaacccggag catgatgatg gtattgcctt
    21421 tgtggtatac ccagatgccc ctggctatgt ccgtccccat cgtgcggatc tcaaaaagtc
    21481 catcgcccag gggcttcgtg tccggctccc gcagtaatcg ggcatcatac tccagtttgc
    21541 cgatgagacg gtcaaacttc accctgattt ttacgggtaa tgctgtggct tcttccctgg
    21601 cttccgggtg ataaacaacg ctaaacatgt gacctcccat ttccattaat attaacctat
    21661 aggctaatgt taggcaaggt gaaaattaac ctgtaagcta atttttaggg aggggtatgc
    21721 gaccagctat gacacggacc cagcattgac aaaaggctct aaaattgtat tttttaactt
    21781 ttacgttcct ttttacatca gtgccttaac attttttcta tgtactgaac gaagggataa
    21841 ttttgagaca aggatacaat tatatgaaag tgaattatct ggcaccgtta ttatgtattg
    21901 gcgtgttggc gctgaccggt tgtaacgatc caaagaaacc ctccgaaagt aatttcaaag
    21961 aagccgcaca gcagtatctg gatactgtat acccggcatg ttatatcaaa gctaatttcc
    22021 cttacaaaac agatggtttc aacattaaca acatgccaga aatattgcat gcaatggcag
    22081 aaaaagggtt gttaactgaa acggcactgt tgcaaagtta gcgatgaggc agccttttgt
    22141 cttattcaaa ggccttacat ttcaaaaact ctgcttacca ggcgcatttc gcccagggga
    22201 tcaccataat aaaatgctga ggcctggcct ttgcgtagtg cacgcatcac ctcaatacct
    22261 ttgatggtgg cgtaagccgt cttcatggat ttaaatccca gcgtggcgtt gattatccgt
    22321 ttcagtttgc catgatcgca ttcaatcacg ttgttccggt acttaatctg tcggtgttca
    22381 acgtcagacg ggcaccggcc ttcgcgtttg agcagagcaa gcgcgcgacc ataggcgggc
    22441 gctttatccg tgttgatgaa tcgtgggatc tgccacttct tcacgttgtt gaggatttta
    22501 cccagaaacc ggtatgcagc tttgctgtta cgacgggagg agagataaaa atcgacagtg
    22561 cggccccggc tgtcgacggc ccggtacaga tacgcccagc ggccattgac cttcacgtag
    22621 gtttcatcca tgtgccacgg gcaaagatcg gaagggttac gccagtacca gcgcagccgt
    22681 ttttccattt caggcgcata acgctgaacc cagcggtaaa tcgtggagtg atcgacattc
    22741 actccgcgtt cagccagcat ctcctgcagc tcacggtaac tgatgccgta tttgcagtac
    22801 cagcgtacgg cccacagaat gatgtcacgc tgaaaatgcc ggcctttgaa tgggttcatg
    22861 tgcagctcca tcagcaaaag gggatgataa gtttatcacc accgactatt tgcaacagtg
    22921 ccccttaacg tgagttttcg ttccactgag cgtcagaccc ctgaaactgc tgaatgcgtt
    22981 gctgcacatc actccgtgat tttccggtcg ctttatcctt tgcgcccata tcccagaact
    23041 gccggaaaaa aggcaccatc attcgtgttg tgtcagcttt ctgggtggaa aaattgggat
    23101 caaaaccgtc atctgaagca tatacgtaat gccgggtatg ctgttccacg ctgccctttg
    23161 gagcacaggc agtgagagtt gctgtcgctg ttatcatggc gataagacac agtttgctgc
    23221 cggaacgtct catgagcgtc tccttacctt taattctttt ttctcattga gttatatatc
    23281 cgcaggctat cttatcatca gtttctgacc gtgttcagtg accgaacaac ccgaaccaga
    23341 ccccccgttt cttttcctgt cccggagggg gctttctggt atctcatata atgatttcag
    23401 taaaacatac tgaggccgga gaacggcgcc gtttgtgctg gtttttgttg catctggagg
    23461 ggattgcgca tggtgtgagt ggctgttttt ttgatcattt tcacaaaaac gcaaatttac
    23521 agacttgaca tgaaaaacaa ggcagcgtaa tttttatact gtatataaaa ccagtggtta
    23581 tatgtacagt attttatttt agtttattgt tttaaaagtc aaagaggaaa agtatatgag
    23641 tggcggagac ggacgaggtc cgggtaattc aggtctggga cacaatggtg gtcaggccag
    23701 tgggaatgtg aacggtacat caggtaaagg tggcccttca tcaggtggtg gtacggatcc
    23761 aaacagcggg ccgggctggg gtacgacgca tacacctaac ggggatattc ataactataa
    23821 cccgggggag tttggtaacg gcgggagtaa acccggtggt aatggcggta acagcggcaa
    23881 tcatagcggg agctctggtg gcggacagtc ttcggccacc gcgatggcct tcggtctgcc
    23941 tgccttggcc actccggggg ctgaaggact ggctttatcc gtttccggcg atgcgttgtc
    24001 ggccgctgtt gctgatgtgc tggctgccct gaaaggtccg tttaagtttg gtctgtgggg
    24061 gattgcgatt tacggagtgc tgccttctga gatagcaaaa gatgatccga aaatgatgtc
    24121 aaaaatcgtg acgtcattgc cggcagacac ggtaacggag acgccggtca gctccctgcc
    24181 gctggaccag gcgacggtca gcgtcactaa acgtgtggcg gatattgtga aggacgagcg
    24241 gcagcatatt gcggttgtca ccggccggcc aatgagtgtt cctgtggtgg atgcgaaacc
    24301 gacaaaacgt ccgggggtat tcagtgtgtc gattccgggt ctcccgtctc tgcaggtgag
    24361 cgtacctaaa ggtgttccgg ccgcgaaagc cccgccaaaa ggcattattg ctgaaaaagg
    24421 tgattcacgt ccggctggtt ttacggccgg tggtaactcc cgtgaagccg ttattcgttt
    24481 cccgaaagag agcggacaga aaccggtcta tgtgtcggtg acggatgttc ttactccggc
    24541 acaggtaaaa cagcgtctgg aggaagaaaa gcgtcgccag caggcatggg acgctgctca
    24601 cccggaagag gggctgaaaa gagagtatga taaagcgaaa gctgagctgg atgctgaaga
    24661 taaaaatatt gcgaccttaa acagtcgcat tgcatcgaca gagaaggcga tccccggtgc
    24721 aagggctgct gttcaggaag ccgataaaaa ggtaaaagag gcagaggcaa ataaagatga
    24781 ttttgtgact tataacccgc ctcatgaata tggctccggg tggcaggatc aggttcgcta
    24841 tcttgataag gatattcaga atcagaatga gaaattaaaa gctgcccaga catctttaaa
    24901 cgaaatgaat gaatccttat ccagggataa ggctgcgctt tccggggcga tggagagccg
    24961 gaaacaaaag gagaaaaaag cgaaggatgc agaaaataaa ttaaatgagg aaaagaaaaa
    25021 acctcgtaag ggaactaaag attacggcca tgattatttt cctgatccca agactgaaga
    25081 tattaagggg ttgggagagt tgaaagaggg taaacctaaa acccctaaac aaggtggtgg
    25141 tggtaagcgg gcccgatggt atggtgataa aaagcgtaaa atttatgaat gggattccca
    25201 gcacggtgag cttgaagggt accgcgccag tgatggcgaa cacctcgggg cattcgatcc
    25261 aaaaacgggt aagcaggtta aagggccgga tccaaaacga aacattaaaa aatatcttta
    25321 agaggtaaat atggggctta aattacatat tcattggttt gataagaaaa ccgaagagtt
    25381 taaaggtggt gaatactcaa aagacttcgg tgatgatggt tctgtcattg aaagtctggg
    25441 gatgccttta aaggataata ttaataatgg ttggtttgat gttgaaaaat catgggtttc
    25501 gatattacag ccacacttta aaaatgtaat cgatattagt aaatttgatt actttgtatc
    25561 ctttgtttac cgggatggta actggtaagc aaaagttatc aaggatgatt tgaaatacag
    25621 acttccggtg ttcagggatg aataccgggg tttttaaata cagggaaggt atatgaaaaa
    25681 ggtaaaggtt gtttttcttt ttatattgat tttttcaggc tttcttctgg tcgcatgtca
    25741 ggcaaactat atccgggatg ttcagggtgg aacggtggca ccatcgtcct cctctgaact
    25801 gacggggatc gcggttcagt agaaaagatc aaaggatctt cttgagatcc tttttttctg
    25861 cgcgtaatct tttgccctgt aaacgaaaaa accacctggg gaggtggttt gatcgaaggt
    25921 taagtcagtt ggggaactgc ttaaccgtgg taactggctt tcgcagagca cagcaaccaa
    25981 atctgtcctt ccagtgtagc cggactttgg cgcacacttc aagagcaacc gcgtgtttag
    26041 ctaaacaaat cctctgcgaa ctcccagtta ccaatggctg ctgcca
//
