LOCUS       NZ_CP045020            28729 bp    DNA     circular CON 09-JAN-2024
DEFINITION  Klebsiella pneumoniae subsp. pneumoniae strain BK13048 plasmid
            pBK13048-6, complete sequence.
ACCESSION   NZ_CP045020
VERSION     NZ_CP045020.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN12984737
            Assembly: GCF_009025895.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae subsp. pneumoniae
  ORGANISM  Klebsiella pneumoniae subsp. pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 28729)
  AUTHORS   Chen,L.
  TITLE     Genomic sequencing of K. pneumoniae strain BK13048
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 28729)
  AUTHORS   Chen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2019) HMH-CDI, Hackensack-Meridian Health Center
            for Discovery and Innovation, 340 Kingsland Street, Building 102,
            Nutley, NJ 07110, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-MAY-2019
            Assembly Method                   :: Unicycler v. v0.4.8-beta
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/09/2024 02:43:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,516
            CDSs (total)                      :: 5,393
            Genes (coding)                    :: 5,265
            CDSs (with protein)               :: 5,265
            Genes (RNA)                       :: 123
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 85
            ncRNAs                            :: 13
            Pseudo Genes (total)              :: 128
            CDSs (without protein)            :: 128
            Pseudo Genes (ambiguous residues) :: 0 of 128
            Pseudo Genes (frameshifted)       :: 60 of 128
            Pseudo Genes (incomplete)         :: 63 of 128
            Pseudo Genes (internal stop)      :: 16 of 128
            Pseudo Genes (multiple problems)  :: 11 of 128
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045020.1.
            Bacteria and source DNA available from HMH-CDI.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..28729
                     /organism="Klebsiella pneumoniae subsp. pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="BK13048"
                     /host="Homo sapiens"
                     /sub_species="pneumoniae"
                     /db_xref="taxon:72407"
                     /plasmid="pBK13048-6"
                     /collection_date="2003"
                     /collected_by="CDI"
     gene            1..858
                     /gene="repA"
                     /locus_tag="F9865_RS27270"
                     /old_locus_tag="F9865_27285"
     CDS             1..858
                     /gene="repA"
                     /locus_tag="F9865_RS27270"
                     /old_locus_tag="F9865_27285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052675.1"
                     /GO_process="GO:0006276 - plasmid maintenance [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="incFII family plasmid replication initiator RepA"
                     /protein_id="WP_000130646.1"
                     /translation="MTDLHQTYYRQVKNPNPVFTPREGAGTLKFCEKLMEKAVGFTSRF
                     DFAIHVAHARSRGLRRRMPPVLRRRAIDALLQGLCFHYDPLANRVQCSITTLAIECGLA
                     TESAAGKLSITRATRALTFLSELGLITYQTEYDPLIGCYIPTDITFTSALFAALDVSEE
                     AVAAARRSRVVWENKQRKKQGLDTLGMDELIAKAWRFVRERFRSYQTELKSRGIKRARA
                     RRDADRERQDIVTLVKRQLTREIAEGRFTANREAVKREVERRVKERMILSRNRNYSRLA
                     TASP"
                     /name="repA"
     gene            1797..2450
                     /locus_tag="F9865_RS27280"
                     /old_locus_tag="F9865_27295"
     CDS             1797..2450
                     /locus_tag="F9865_RS27280"
                     /old_locus_tag="F9865_27295"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001757010.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_000616807.1"
                     /translation="MIQTRNQYLQFMLVMLAAWGISWGARFVMEQAVLLYGSGKNYLFF
                     SHGTVLMYLLCVFLVYRRWIAPLPVVGQLRNVGVPWLVGAMAVVYVGVFLLGKALALPA
                     EPFMTKLFADKSIPDVILTLLTIFILAPLNEETLFRGIMLNVFRSRYCWTMWLGALITS
                     LLFVAAHSQYQNLLTLAELFLVGLITSVARIRSGGLLLPVLLHMEATTLGLLFG"
                     /name="CPBP family intramembrane glutamic endopeptidase"
     gene            2543..2800
                     /gene="pemI"
                     /locus_tag="F9865_RS27285"
                     /old_locus_tag="F9865_27300"
     CDS             2543..2800
                     /gene="pemI"
                     /locus_tag="F9865_RS27285"
                     /old_locus_tag="F9865_27300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000557619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system antitoxin PemI"
                     /protein_id="WP_000557619.1"
                     /translation="MHTTRLKRVGGSVMLTVPPALLNALSLGTDNEVGMVIDNGRLIVE
                     PYRRPQYSLAELLAQCDPNAEISAEEREWLDAPATGQEEI"
                     /name="pemI"
     gene            2733..3134
                     /gene="pemK"
                     /locus_tag="F9865_RS27290"
                     /old_locus_tag="F9865_27305"
     CDS             2733..3134
                     /gene="pemK"
                     /locus_tag="F9865_RS27290"
                     /old_locus_tag="F9865_27305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001398199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /protein_id="WP_001398199.1"
                     /translation="MLKYQLKNENGWMHRRLVRRKSDMERGEIWLVSLDPTAGHEQQGT
                     RPVLIVTPAAFNRVTRLPVVVPVTSGGNFARTAGFAVSLDGVGIRTTGVVRCDQPRTID
                     MKARGGKRLERVPETIMNEVLGRLSTILT"
                     /name="pemK"
     gene            complement(3271..>5847)
                     /locus_tag="F9865_RS27295"
                     /old_locus_tag="F9865_27310"
                     /pseudo=""
     CDS             complement(3271..>5847)
                     /locus_tag="F9865_RS27295"
                     /old_locus_tag="F9865_27310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014330913.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn5403 family transposase"
                     /name="Tn3-like element Tn5403 family transposase"
     gene            complement(5900..6604)
                     /locus_tag="F9865_RS27305"
                     /old_locus_tag="F9865_27320"
     CDS             complement(5900..6604)
                     /locus_tag="F9865_RS27305"
                     /old_locus_tag="F9865_27320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221000.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS26 family transposase"
                     /protein_id="WP_001067858.1"
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIINATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="IS6-like element IS26 family transposase"
     gene            8184..8418
                     /locus_tag="F9865_RS27325"
                     /old_locus_tag="F9865_27340"
                     /pseudo=""
     CDS             8184..8418
                     /locus_tag="F9865_RS27325"
                     /old_locus_tag="F9865_27340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003382250.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]; GO:0009432 - SOS response [Evidence IEA]"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            8546..8827
                     /locus_tag="F9865_RS27330"
                     /old_locus_tag="F9865_27345"
     CDS             8546..8827
                     /locus_tag="F9865_RS27330"
                     /old_locus_tag="F9865_27345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001333089.1"
                     /translation="MNYDEITKITAERISDYMTEAVNTDSKSVAEMFHNAAWGVLSLWF
                     ELVTKIDLDIHKKNRYASYDFRRKIEMQHEEFQKMTEREQVPLLKLPE"
                     /name="hypothetical protein"
     gene            complement(8950..9300)
                     /locus_tag="F9865_RS27335"
                     /old_locus_tag="F9865_27350"
     CDS             complement(8950..9300)
                     /locus_tag="F9865_RS27335"
                     /old_locus_tag="F9865_27350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001630992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid partitioning/stability family protein"
                     /protein_id="WP_000361389.1"
                     /translation="MDKRRTIAFKLNPDVNQTDKIVCDTLDSIPQGERSRLNRAALTAG
                     LALYRQDPRTPFLLCELLTKETTFSDIVNILRSLFPKEMADFNSSIVTQSSSQQEQKSD
                     EETKKNAMKLIN"
                     /name="plasmid partitioning/stability family protein"
     gene            complement(9303..10265)
                     /gene="parM"
                     /locus_tag="F9865_RS27340"
                     /old_locus_tag="F9865_27355"
                     /gene_synonym="stbA"
     CDS             complement(9303..10265)
                     /gene="parM"
                     /locus_tag="F9865_RS27340"
                     /old_locus_tag="F9865_27355"
                     /gene_synonym="stbA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000959884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid segregation protein ParM"
                     /protein_id="WP_000959884.1"
                     /translation="MLVFIDDGSTNIKLQWQESDGTIKQHISPNSFKREWAVSFGDKKV
                     FNYTLNGEQYSFDPISPDAVVTTNIAWQYSDVNVVAVHHALLTSGLPVSEVDIVCTLPL
                     TEYYDRNNQPNTENIERKKANFRKKITLNGGDTFTIKDVKVMPESIPAGYEVLQELDEL
                     DSLLIIDLGGTTLDISQVMGKLSGISKIYGDSSLGVSLVTSAVKDALSLARTKGSSYLA
                     DDIIIHRKDNNYLKQRINDENKISIVTEAMNEALRKLEQRVLNTLNEFSGYTHVMVIGG
                     GAELICDAVKKHTQIRDERFFKTNNSQYDLVNGMYLIGN"
                     /name="parM"
     gene            10412..10705
                     /locus_tag="F9865_RS27345"
                     /old_locus_tag="F9865_27360"
     CDS             10412..10705
                     /locus_tag="F9865_RS27345"
                     /old_locus_tag="F9865_27360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002430945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_032146011.1"
                     /translation="MFLGFVWRVTKDVAGLLFLLRRLTRRGRNAACGQCPASGRARDGR
                     FYRSRLALVTVYASPSPFSDERPSSRFRGISSPSKRRRLRYSTVGLTRYRTR"
                     /name="hypothetical protein"
     gene            10782..11465
                     /locus_tag="F9865_RS27355"
                     /old_locus_tag="F9865_27370"
     CDS             10782..11465
                     /locus_tag="F9865_RS27355"
                     /old_locus_tag="F9865_27370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA methylase"
                     /protein_id="WP_000085883.1"
                     /translation="MSRFILGDCVRVMATFPGNAVDFILTDPPYLVGFRDRSGRTIAGD
                     KTDEWLQPACNEMYRVLKKDALMVSFYGWNRVDRFMAAWKNAGFSVVGHLVFTKNYTSK
                     AAYVGYRHECAYILAKGRPRLPQNPLPDVLGWKYSGNRHHPTEKPVTSLQPLIESFTHP
                     NAIVLDPFAGSGSTCVAALQSGRRYIGIELLEQYHRAGQQRLAAVQRAMQQGAANDDWF
                     MPEAA"
                     /name="DNA methylase"
     gene            11466..11687
                     /locus_tag="F9865_RS27360"
                     /old_locus_tag="F9865_27375"
     CDS             11466..11687
                     /locus_tag="F9865_RS27360"
                     /old_locus_tag="F9865_27375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_858332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001104881.1"
                     /translation="MNYAGHEKLRAEVAEVANAMCDLRTTMNEMEQRYSFNADTLPERL
                     VRQTLFRANRLLMEAYTEILELEACFKD"
                     /name="hypothetical protein"
     gene            11701..12135
                     /locus_tag="F9865_RS27365"
                     /old_locus_tag="F9865_27380"
     CDS             11701..12135
                     /locus_tag="F9865_RS27365"
                     /old_locus_tag="F9865_27380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001562898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1380 family protein"
                     /protein_id="WP_000274503.1"
                     /translation="MYGTCETLCRELAVKYPGDMPLMLVIWSPEEIQALADGMEISLTG
                     HEIRTVLARLEDIPEDQRIESGISSAAVMEIIRNESENRLVTVPAELLASLIQTAEQAL
                     WKREWAARDHGLAVPECVTRRQEVVNQARTLLKNNTHEND"
                     /name="DUF1380 family protein"
     gene            12186..12962
                     /locus_tag="F9865_RS28395"
     CDS             12186..12962
                     /locus_tag="F9865_RS28395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001383963.1"
                     /translation="MNENSTLNALICRHARNLLLAQGWPEETDVDQRNPKYPGWISIYV
                     LLDAPRLATLLINRHGGVLPPLLASAIQKLTGTGAELVLSGSQWQSLPVLPADGTQVSF
                     PYAGEWLTEDEIRAVLAAVRDAVRSVSCRVAEDARRIRAALTTTGQTLLTRQTRRFRLV
                     VKESDHPCWLDEDDENLPVVLDAIVNRGARFSSVEMYLVSDCIEHILSSGLACDVLRIP
                     DEPPRRWFDRGVLREVVREARAEIRSMADALAKIRK"
                     /name="hypothetical protein"
     gene            13380..13805
                     /locus_tag="F9865_RS27380"
                     /old_locus_tag="F9865_27395"
     CDS             13380..13805
                     /locus_tag="F9865_RS27380"
                     /old_locus_tag="F9865_27395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_490551.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein"
                     /protein_id="WP_001198928.1"
                     /translation="MQYAKPVTLNVEECDRLSFLPYLFGNDFLYAEAYVYALAQKMMPE
                     YQGGFWHFIRLPDGGGYMMPDGDRFHMVNGANWFDRTVSADAAGIILTSLVINRQLWLY
                     HDSGDAGLTQLYRMRDAQLWRHIEFHPECNAIYAALD"
                     /name="antirestriction protein"
     gene            13852..14274
                     /locus_tag="F9865_RS27385"
                     /old_locus_tag="F9865_27400"
     CDS             13852..14274
                     /locus_tag="F9865_RS27385"
                     /old_locus_tag="F9865_27400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1380 family protein"
                     /protein_id="WP_001763816.1"
                     /translation="MYCTVKEIIREVLDTDVPDSECVFAVVLTRGDVRHIAQDWSLTDD
                     ELETVMQRLDDAFAHGADVSIVHDVVRELMEEKRASRQVTVPAVMLEKVMALAGSEMKR
                     LYAVGSENGGDGDAFVREEREAMDVVLQALDGEHMS"
                     /name="DUF1380 family protein"
     gene            14271..14462
                     /locus_tag="F9865_RS27390"
                     /old_locus_tag="F9865_27405"
     CDS             14271..14462
                     /locus_tag="F9865_RS27390"
                     /old_locus_tag="F9865_27405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016238862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001027493.1"
                     /translation="MNISTETREILRNYKAVINARRREMGQKPLTTAQIVDEICDFVAN
                     QQAVFLGGHYILQGSINR"
                     /name="hypothetical protein"
     gene            complement(14735..14983)
                     /locus_tag="F9865_RS28650"
     CDS             complement(14735..14983)
                     /locus_tag="F9865_RS28650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001403191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_071557811.1"
                     /translation="MSRGPPQRRRARARNGVAPYIPAAFCRDAGSAGHGATEAARPERS
                     LQARGFHASDRSGSPKPRQRVRRRLAGAPAAACRSRA"
                     /name="hypothetical protein"
     gene            15500..15730
                     /locus_tag="F9865_RS27400"
                     /old_locus_tag="F9865_27415"
     CDS             15500..15730
                     /locus_tag="F9865_RS27400"
                     /old_locus_tag="F9865_27415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000218642.1"
                     /translation="MTVSIVSPSAAAVKPRRHPRFRREDIPAPEIDPVLKAFGRHIARS
                     FHRGRGVHIPAMKNTAFGQVLRTLELKRAFN"
                     /name="hypothetical protein"
     gene            15782..17143
                     /locus_tag="F9865_RS27405"
                     /old_locus_tag="F9865_27420"
     CDS             15782..17143
                     /locus_tag="F9865_RS27405"
                     /old_locus_tag="F9865_27420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3560 domain-containing protein"
                     /protein_id="WP_000170695.1"
                     /translation="MTLAAITMTAPEAASPVQMYRATYSPDDNKLRLYAASRLDPETYK
                     KVHDAGFRWAPRQALFVAPAWTPGREDVLLSLAGEIEDEDSTLAERQEARAERFTGYSG
                     KRASESAQALDEVERLAAMIPPGQPILVGHHSERRARRDAQRIENGMKRAVMLFERAEY
                     WEERARSALLHAKYKERPDVRWRRIKKIEADLRKAEKTIAQSQKYLTMWRAESLDLNMA
                     KLISSHDHISACFPLDTYPRPAEKSQYEGSRSLWSALDDDIITTEQAREIAIRCHERQI
                     QHQQRWVNHYQNRLIYERAMLDESGGVVTRTQDFEPGGQVFSRGEWLTIIRVNKSNGAV
                     SSVTTPNYSFLGYSGTMKVTPDRITDYKAPSAEEAAVASQAAKRPPVVNYPGEGFREMT
                     KAQWAALPRDCKAVRSVEEAEDHGAYRYRRTMDNNFRLVNVYITDMKITEIPQK"
                     /name="DUF3560 domain-containing protein"
     gene            17190..17753
                     /locus_tag="F9865_RS27410"
                     /old_locus_tag="F9865_27425"
     CDS             17190..17753
                     /locus_tag="F9865_RS27410"
                     /old_locus_tag="F9865_27425"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052654.1"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]; GO:1904047 - S-adenosyl-L-methionine
                     binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_001298559.1"
                     /translation="MHSQLRERIRLMRARLDNAAPVAEIRAESQLFVSPAPICDRLVTL
                     AEISNRDHILEPSAGTGAILRAIRDTAPEAMCDAVEINSGLVRYLRENFNGVRVQCGDF
                     MEWQSVQYYSRIIMNPPFSHGQDIRHILRAFSLLRPGGVLVAVCLNGPRQQEKLLPFSD
                     VREELPRGTFAYTDVPTMIIRLRA"
                     /name="class I SAM-dependent methyltransferase"
     gene            complement(17839..18300)
                     /locus_tag="F9865_RS28655"
                     /old_locus_tag="F9865_27435"
                     /pseudo=""
     CDS             complement(17839..18300)
                     /locus_tag="F9865_RS28655"
                     /old_locus_tag="F9865_27435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052655.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            18602..19129
                     /locus_tag="F9865_RS27430"
                     /old_locus_tag="F9865_27445"
     CDS             18602..19129
                     /locus_tag="F9865_RS27430"
                     /old_locus_tag="F9865_27445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001276102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="WP_000290834.1"
                     /translation="MAVRGINKVILVGRLGKDPEVRYIPNGGAVANLQVATSETWRDKQ
                     TGEMKEQTEWHRVVLFGKLAEVAGEYLRKGAQVYIEGQLRTRSWEDNGITRYVTEILVK
                     TTGTMQMLGSAPQQNAQVQPQPQQNGQSQSADATKKGSAKTKGRGRKAAQPEPQPQPPE
                     GEDYGFSDDIPF"
                     /name="single-stranded DNA-binding protein"
     gene            19187..19420
                     /locus_tag="F9865_RS27435"
                     /old_locus_tag="F9865_27450"
     CDS             19187..19420
                     /locus_tag="F9865_RS27435"
                     /old_locus_tag="F9865_27450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_958724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF905 family protein"
                     /protein_id="WP_000006003.1"
                     /translation="MSEYFRILQGLPDGPFTRKQAEAVAAQYRNVFIEDDHGEQFRLVV
                     RNNGTMVWRTWNFEDGAGYWMNHVIRDFGILK"
                     /name="DUF905 family protein"
     gene            19481..21504
                     /locus_tag="F9865_RS27440"
                     /old_locus_tag="F9865_27455"
                     /pseudo=""
     CDS             19481..21504
                     /locus_tag="F9865_RS27440"
                     /old_locus_tag="F9865_27455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052657.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="ParB/RepB/Spo0J family partition protein"
                     /name="ParB/RepB/Spo0J family partition protein"
     gene            21573..22007
                     /gene="psiB"
                     /locus_tag="F9865_RS27445"
                     /old_locus_tag="F9865_27460"
     CDS             21573..22007
                     /gene="psiB"
                     /locus_tag="F9865_RS27445"
                     /old_locus_tag="F9865_27460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000845953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugation system SOS inhibitor PsiB"
                     /protein_id="WP_000845953.1"
                     /translation="MKTELTLNVLQTMSAQEYEDIRAAGSDERRELTHAVMRELDAPDN
                     WTMNGEYGSEFGGFFPVQVRFTPAHERFHLALCSPGDVSQVWVLVLVNAGGEPFAVVQV
                     QRRFAPEAVSHSLALAASLDAQGYSVSDIIHILMAEGGQA"
                     /name="psiB"
     gene            22004..22723
                     /locus_tag="F9865_RS27450"
                     /old_locus_tag="F9865_27465"
     CDS             22004..22723
                     /locus_tag="F9865_RS27450"
                     /old_locus_tag="F9865_27465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001763821.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid SOS inhibition protein A"
                     /protein_id="WP_001276217.1"
                     /translation="MSARSQALVPLSAEQQAAWRAVAETEKRRHQGNTLAEYPYAGAFF
                     RCLNGSRRISLSDLRFFMPSLTAEELRGNRSQWLYAVDVLIETQGEVCLLPLPGDAAER
                     LFPSVRFRVRERSRHKSALVMQKYSRQQAREAEQKARAYQALVAQAEIELAFHSPETVG
                     SWHARWSDRVAEHDLETLFWQWGERFPSLAGMERWQWQDMPFWQVIAEASLAAREAGHA
                     VREMERWMVPNKLREAA"
                     /name="plasmid SOS inhibition protein A"
     gene            22945..>23094
                     /gene="mok"
                     /locus_tag="F9865_RS28660"
                     /pseudo=""
     CDS             22945..>23094
                     /gene="mok"
                     /locus_tag="F9865_RS28660"
                     /inference="COORDINATES: protein motif:HMM:NF010277.0"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid maintenance protein Mok"
                     /name="mok"
     gene            23036..23161
                     /locus_tag="F9865_RS27455"
                     /old_locus_tag="F9865_27470"
     CDS             23036..23161
                     /locus_tag="F9865_RS27455"
                     /old_locus_tag="F9865_27470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Hok family toxin"
                     /protein_id="WP_001372321.1"
                     /translation="MLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK"
                     /name="type I toxin-antitoxin system Hok family toxin"
     gene            23519..23944
                     /locus_tag="F9865_RS27460"
                     /old_locus_tag="F9865_27475"
     CDS             23519..23944
                     /locus_tag="F9865_RS27460"
                     /old_locus_tag="F9865_27475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001373091.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0004803 - transposase activity [Evidence IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="WP_000422741.1"
                     /translation="MELQDWRKEPRKNYSNEFKLRMVELASQPGACVAQIARENGVNDN
                     VIFKWLRLWQNEGRVSRRLPVTTSSDTGVELLPVEITPDEQKEPVAAIAPSLSTSTQTR
                     VSASSCKVEFRHGNMTLENPSPELLTVLIRELTGRGR"
                     /name="transposase"
     gene            23941..24291
                     /gene="tnpB"
                     /locus_tag="F9865_RS27465"
                     /old_locus_tag="F9865_27480"
     CDS             23941..24291
                     /gene="tnpB"
                     /locus_tag="F9865_RS27465"
                     /old_locus_tag="F9865_27480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_311895.1"
                     /note="TnpB, as the term is used for proteins encoded by
                     IS66 family insertion elements, is considered an accessory
                     protein, since TnpC, encoded by a neighboring gene, is a
                     DDE family transposase; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="WP_000624722.1"
                     /translation="MISLPSGTRIWLVAGVTDMRKSFNGLGEQVQHVLNDNPFSGHLFI
                     FRGRRGDTVKILWADADGLCLFTKRLEEGQFIWPAVRDGKVSITRSQLAMLLDKLDWRQ
                     PKTSSRNSLTML"
                     /name="tnpB"
     gene            24322..25935
                     /locus_tag="F9865_RS27470"
                     /old_locus_tag="F9865_27485"
     CDS             24322..25935
                     /locus_tag="F9865_RS27470"
                     /old_locus_tag="F9865_27485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000080195.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66-like element ISEc23 family transposase"
                     /protein_id="WP_000080200.1"
                     /translation="MSQKYLIRIAELERLLSEQAEALRQKDQQLSLVEETEAFLRSALT
                     RAEEKIEEDEREIEHLRAQIEKLRRMLFGTRSEKLRREVELAEALLKQREQDSDRYSGR
                     EDDPQVPRQLRQSRHRRPLPAHLPREIHRLEPEESCCPECGGKLDYLGEVSAEQLELVS
                     SALKVIRTERVKKACTKCDCIVEAPAPSRPIERGIAGPGLLARVLTGKYCEHLPLYRQS
                     EIFARQGVELSRALLSNWVDACCQLMTPVNDALYRYVMNTRKIHTDDTPVKVLAPGQKK
                     AKTGRIWTYVRDDRNVGSSSPPAVWFAYSPNRQGKHPEQHLRPFRGILQADAFTGYDRL
                     FSAEREGGALTEVACWAHARRKIHDVYISSKSATAEEALKRISELYAIEDEIRGLPESE
                     RLAVRQQRSKVLLTSLHEWMVEKNGTLSKKSRLGEAFSYVLNQWDALCYYSDDGLAEAD
                     NNAAERALRAVCLGKKNFMFFGSDHGGERGALLYGLIGTCRLNGIDPEAYLRHILSVLP
                     EWPSNRVDELLPWNVVLTNK"
                     /name="IS66-like element ISEc23 family transposase"
     gene            complement(<26020..26316)
                     /locus_tag="F9865_RS28400"
                     /pseudo=""
     CDS             complement(<26020..26316)
                     /locus_tag="F9865_RS28400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052655.1"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            26671..27368
                     /locus_tag="F9865_RS27490"
                     /old_locus_tag="F9865_27505"
     CDS             join(26671..26920,26920..27368)
                     /locus_tag="F9865_RS27490"
                     /old_locus_tag="F9865_27505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558260.1"
                     /ribosomal_slippage=""
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1-like element IS1B family transposase"
                     /protein_id="WP_095033700.1"
                     /translation="MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTY
                     TASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTIFRHFKKLRPQSVTSRIQPGSDVIV
                     CAEMDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIW
                     MTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVI
                     GHYLNIKHYQ"
                     /name="IS1-like element IS1B family transposase"
     gene            27365..27931
                     /locus_tag="F9865_RS27495"
                     /old_locus_tag="F9865_27510"
     CDS             27365..27931
                     /locus_tag="F9865_RS27495"
                     /old_locus_tag="F9865_27510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_858390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2726 domain-containing protein"
                     /protein_id="WP_151887008.1"
                     /translation="MSWSHYPLLIRIILRSVNQHSPLLMQLHAAGIRTGDAERILSGGE
                     YWQRQKTLLTEREVSFMKGLFRIVDMKRWYLCPQVRVADIVQLNGNIRPRSRQWWQLFR
                     MVSQWHVDVVIVERRSFSIVAAVELDDASHLRPERRRRDILLEEVLRQAGIPLLRSHDA
                     RKLLQMTGEWLNTTGADQQSPEHRS"
                     /name="DUF2726 domain-containing protein"
     gene            28171..28425
                     /locus_tag="F9865_RS27500"
                     /old_locus_tag="F9865_27515"
     CDS             28171..28425
                     /locus_tag="F9865_RS27500"
                     /old_locus_tag="F9865_27515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication regulatory protein RepA"
                     /protein_id="WP_000083830.1"
                     /translation="MSQTENAVTSSSGAKRAYRKGNPLSDAEKQRLSVARKRASFKEVK
                     VFLEPKYKAMLMQMCHEDGLTQAEVLTALIKSEAQKRCM"
                     /name="replication regulatory protein RepA"
     gene            28532..28717
                     /gene="copA"
                     /locus_tag="F9865_RS28680"
                     /gene_synonym="incA; repA3"
     CDS             28532..28717
                     /gene="copA"
                     /locus_tag="F9865_RS28680"
                     /gene_synonym="incA; repA3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012615301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid copy control protein CopA"
                     /protein_id="WP_012615301.1"
                     /translation="MWIYRSQKSKNPDNLLQLWRVRKDYRGPLKPYSQQFSYAGSIVIC
                     PEKFKTSFCARSFCAL"
                     /name="copA"
     Typing          32..858
                     /name="IncFIA"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.517"
                     /coverage="97.0"
                     /evalue="0.0"
     Typing          complement(28473..28729)
                     /name="IncFIC"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="99.0"
                     /evalue="2.94e-132"
ORIGIN
        1 gtgactgatc ttcaccaaac gtattaccgc caggtaaaga acccgaatcc ggtgtttaca
       61 ccccgtgaag gtgcaggaac gctgaagttc tgcgaaaaac tgatggaaaa ggcggtgggc
      121 ttcacttccc gttttgattt cgccattcat gtggcgcatg cccgttcgcg tggtctgcgt
      181 cgacgcatgc caccagtgct gcgtcgacgg gctattgatg cgctcctgca ggggctgtgt
      241 ttccactatg acccgctggc caaccgcgtc cagtgctcca tcaccacgct ggccattgag
      301 tgcggactgg cgacggagtc tgctgccgga aaactctcca tcacccgtgc cacccgggcc
      361 ctgacgttcc tgtcagagct gggactgatt acctaccaga cggaatatga cccgcttatc
      421 gggtgctaca ttccgaccga tatcacgttc acatctgcac tgtttgctgc cctcgatgta
      481 tcagaggagg cagtggccgc cgcgcgccgc agccgtgtgg tatgggaaaa caaacaacgc
      541 aaaaagcagg ggctggatac cctgggcatg gatgaactga tagcgaaagc ctggcgtttt
      601 gttcgtgagc gttttcgcag ttatcagaca gagcttaagt cccggggaat aaagcgtgcc
      661 cgtgcgcgtc gtgatgcgga cagggaacgt caggatattg tcaccctggt gaaacggcag
      721 ctgacgcgcg aaatcgcgga agggcgcttc actgccaatc gtgaggcggt aaaacgcgaa
      781 gttgagcgtc gtgtgaagga gcgcatgatt ctgtcacgta accgtaatta cagccggctg
      841 gccacagctt ccccctgaaa gtgacctcct ctgaataatc cggcctgcgc cggaggcttc
      901 cgcacgtctg aagcccgaca gcgcacaaaa aatcagcacc acatacaaaa aacaacctca
      961 tcatccagct tctggtgcat ccggcccccc ctgttttcga tacaaaacac gcctcacaga
     1021 cggggaattt tgcttatcca catttaactg caagggactt ccccataagg ttacaaccgt
     1081 tcatgtcata aagcgccagc cgccagtctt acagggtgca atgtatcttt taaacacctg
     1141 tttatatctc ctttaaacta cttaattaca ttcatttaaa aagaaaacct attcactgcc
     1201 tgtcctgtgg acagacagat atgcacctcc caccgcaagc ggcgggcccc gaccggagcc
     1261 actttagtta caacacacaa aaccaacctc cagaaaaacc ccgaaccagc gcagaactga
     1321 aaccacaaag cccctccctc ataactgaaa agcggccccg ccccggccca aagggccgga
     1381 acagagtcgc ttttaattat gaatgttgta actacatctt catcgctgtc agtcttctcg
     1441 ctggaagttc tcagtacacg ctcgtaagcg gccctcacgg cccgctaacg cggagatacg
     1501 ccccgacttc gggtaaaccc tcgtcgggac cactccgacc gcgcacagaa gctctctcat
     1561 ggctgaaagc gggtatggtc tggcagggct ggggatgggt aaggtgaaat ctatcaatca
     1621 gtaccggctt acgccgggct tcggcggttt tactcctgta tcatatgaaa caacagagtg
     1681 ccgccttcca tgccgctgat gcggcatatc ctggtaacga tatctgaatt gttatacatg
     1741 tgtatatacg tggtaatgac aaaaatagga caagttaaaa atttacaggc gatgcaatga
     1801 ttcaaacacg taatcaatat ctgcagttta tgctggttat gctggctgca tggggcatta
     1861 gttggggagc cagatttgtc atggagcagg ccgttctgct ttatggatca ggaaaaaact
     1921 atttgttctt cagtcatggt actgttctga tgtacctgct gtgtgttttc ctggtatacc
     1981 gccgttggat agctccgcta ccggtcgttg gtcagctgcg caacgttggc gtaccgtggc
     2041 tggtcggtgc gatggccgtg gtgtatgtcg gtgtatttct gctcggtaag gcgctggctc
     2101 tgcctgctga gccatttatg acgaaacttt ttgccgataa gtccatacct gacgtgatcc
     2161 tgacgttgct gaccatcttt atccttgccc cgttgaatga ggaaacgctg ttccggggga
     2221 ttatgctgaa cgtcttccgt tcacggtact gctggacgat gtggctgggg gcgctgataa
     2281 cgtcgttgtt gttcgtcgcc gcgcacagcc agtatcagaa cctgctgaca ctggcagaac
     2341 tgttcctggt ggggttgatt acatcagtgg ccaggatcag aagtggtggc ctgctgctgc
     2401 cggtattgct gcatatggaa gcaaccacgc tgggtttact gtttggttga aagttatatt
     2461 tttattaaac attgtgcgtt aaagcctggt gtgttttttt agtggatgtt atatttaaat
     2521 ataactttta tggaggtgaa gaatgcatac cacccgactg aagagggttg gcggctcagt
     2581 tatgctgacc gtcccaccgg cactgctgaa tgcgctgtct ctgggcacag ataatgaagt
     2641 tggcatggtc attgataatg gccggctgat tgttgagccg tacagacgcc cgcaatattc
     2701 actggctgag ctactggcac agtgtgatcc gaatgctgaa atatcagctg aagaacgaga
     2761 atggctggat gcaccggcga ctggtcagga ggaaatctga catggaaaga ggggaaatct
     2821 ggcttgtctc gcttgatcct accgcaggtc atgagcagca gggaacgcgg ccggtgctga
     2881 ttgtcacacc ggcggccttt aatcgcgtga cccgcctgcc tgttgttgtg cccgtaacca
     2941 gcggaggcaa ttttgcccgc actgccggct ttgcggtgtc gttggatggt gttggcatac
     3001 gtaccacagg tgttgtacgt tgcgatcaac cccggacaat tgatatgaaa gcacggggcg
     3061 gaaaacgact cgaacgggtt ccggagacta tcatgaacga agttcttggc cgcctgtcca
     3121 ctattctgac ttgaacatgg ggtttgaggg gcaactggat gaaaacgtac gatttagggc
     3181 actaaaaccg ctgttgtccc accattctgg tgattcccaa acgttatttg gctaaaaggg
     3241 gtcggttccg gctgagggcg aaatgacacc ctaagctttc ggttccttgg gccaaagata
     3301 ttcgccagtc agtagaatgt gcgcccagcc caatggggat atgtggggaa gaaattcagg
     3361 gggaacatcc aacccttcgt tccgccgctc cgtgacggca tgaccaagat ggacggtatt
     3421 ccagtaaatg atcaccgcag tcaataaatt gagcccagcg attcggtagt gctgcccctc
     3481 tgtcgtgcga tcgcgaattt ccccctgcct cccgatacgg agcgcatttt tgagcgcatg
     3541 gtgggcctct cccttgttaa gaccgatctg agcacgccgc tgcatgtccg tatccaggat
     3601 ccactcaata atgaaaaggg tccgttcaat acgaccaact tcacgaagcg caactgcaag
     3661 gttgttttgt cgtgggtaag aagcgagctt gcgcaggagt tggctgggcc tgattttgcc
     3721 agcggtcatc gtcgcggcac aacggaaaat atcaggccag ttcgcaacga taagatcctc
     3781 ccgggctttt ccacctacca acttgcgtaa ctccctgggg gtcgtatcgg gattaaatac
     3841 gtacaaccgc ttcgatggca gatccctgat tcgcagaacg agattgtagc cgagcaggct
     3901 actggctccg aacaaatggt cggtgaatcc tgctgtatcg gcatactgtt cgcgaacatg
     3961 gcgaccgacc tcgttcatca gtagtccatc gagaatatac ggtgcctcgc tcacggtcgc
     4021 cgggatcgac tgacaagcga atggcgcgaa ctggtcgctt acgtgagtat acgctttgag
     4081 gccgggaaca gaaccatatt tggcattgac catgttcatg gcttcgccat gccgcgctgt
     4141 cgggaaaaac tgaccatcgc tcgatgctga cgtgcccatc ccccagacgc gtgacatcgg
     4201 cagtttaccc tgcgcggcca ccacaattgc caatgcctgg ttcatggctt cgctttcaac
     4261 atgccagcgg gcaaggcgtg agagctgcca gtaatcatgc gtgtttgtag cttccgccat
     4321 cttacgcagg cccagattga gcccttcagc gagcaggacg ttgagcagac cgatccggtc
     4381 gcgacatgga gccccggttc tcagatgggt aaacgcatct gtgaaaccaa gggctgcatc
     4441 aacttcaagc agcatgtcgg taatccgaac ggacggcatt cggcgataca gatccagtat
     4501 gagtgcctcg gcaccatccg gcacgtctgc tgtcaacctg tcgatccgca acgttccatc
     4561 ttctatgcta ccgtgcggaa tagtgccgtt acgggcagcc cgggccagcc gcttaagagc
     4621 gatcgtgagt cgcgcctttc tgtctgccag ccaatcctgt gggttggaag gcacggccag
     4681 ttttgcattt tcctgcgccg cgatcatcgg caccagtacc tgcttgaggt caccatagcg
     4741 gcgcgaatga gcgagccaga catctccgga acgaaaagca tcccggaggt gaaagagtac
     4801 cgccacttcc caaagacggg tatctccttt ttcctgagct cgtaaatgac ggttccattt
     4861 ggagctgggc cgcaggaaac gcctttctgg cgatgcaaca cctttcatct ctccgatcga
     4921 caaagctgct gctaccaatg gtccggcgac cggcgcggct tcgagcttca gacagcgcaa
     4981 catgcggggc gcataacgac gaaagcgatg gtatccctgc ccgacatatg caagaggctc
     5041 atcggctagc gtgttgctga gttgagtccc tgtcgctacc agttgagcga gccggtccca
     5101 tgcaaccgaa ctggcgacag ccatctccag cggggttccg tcactgcggg cctcaagcaa
     5161 cgaagctccc agcgcggtga aggtacggat cgtatccgtg agtgtggctt tagagccgga
     5221 aattgtttcg tcatgctggc gcttcgcttc ccgccaggtt tttcctacga tcctgtcatg
     5281 ggtttcgact atggcatcag caatcgccgc ttcccactcc acaacacaga cggcaaggat
     5341 cgcccagcgg cggtccgaag tgatgtcacg caaaccgtcg gtgaagtagc gttcaccctg
     5401 ccgacgcagc cgggcaatgc gatgggcagg tatgctggcc aaagcactat gattgatatt
     5461 cagggtacgc agaaattcga gcctgtcgag caaacggtta gcagcagccg agttgttacc
     5521 aacctcgaag ttgcgaagcc agatgaaacg actgatattg ccggcgagca tttcactcag
     5581 aagtttgtcc aggtgatcgc gaacatccgc tgttaaattt tccgcaatcc gcgtttcaat
     5641 ccgccgctca gcggcgacca gagcatccgc gcacaagcgc tcgattgtcg atactgcggg
     5701 cagaatggtg gaagtttccc gacaccgcac aataaaacga tgagcaagat cctcgtttga
     5761 tctggcatct tcggcctggc cgaaagtcca ctcccgcaga tcacgggcac cacggcccgt
     5821 gaaggtcttg tagccgtaaa tttcgcgggc actgttgcaa agttagcgat gaggcagcct
     5881 tttgtcttat tcaaaggcct tacatttcaa aaactctgct taccaggcgc atttcgccca
     5941 ggggatcacc ataataaaat gctgaggcct ggcctttgcg tagtgcacgc atcacctcaa
     6001 tacctttgat ggtggcgtaa gccgtcttca tggatttaaa tcccagcgtg gcgttgatta
     6061 tccgtttcag tttgccatga tcgcattcaa tcacgttgtt ccggtactta atctgtcggt
     6121 gttcaacgtc agacgggcac cggccttcgc gtttgagcag agcaagcgcg cgaccatagg
     6181 cgggcgcttt atccgtgttg atgaatcgtg ggatctgcca cttcttcacg ttgttgagga
     6241 ttttacccag aaaccggtat gcagctttgc tgttacgacg ggaggagaga taaaaatcga
     6301 cagtgcggcc ccggctgtcg acggcccggt acagatacgc ccagcggcca ttgaccttca
     6361 cgtaggtttc atccatgtgc cacgggcaaa gatcggaagg gttacgccag taccagcgca
     6421 gccgtttttc catttcaggc gcataacgct gaacccagcg gtaaatcgtg gagtgatcga
     6481 cattcactcc gcgttcagcc agcatctcct gcagctcacg gtaactgatg ccgtatttgc
     6541 agtaccagcg tacggcccac agaatgatgt cacgctgaaa atgccggcct ttgaatgggt
     6601 tcatgtgcag ctccatcagc aaaaggggat gataagttta tcaccaccga ctatttgcaa
     6661 cagtgcctct caaaatcggt ggagctgcat gacaaagtca tcgggcatta tctgaacata
     6721 aaacactatc aataagttgg agtcattacc aaacagggat tatttattct ctcaggcgag
     6781 aataaaatag acgaagaatg tttcattaat atagtccaaa cggctgtcgc cataaataac
     6841 atcggtagag aatctaatgg ttatatttta gttggtgttt ccgataccaa agctacggca
     6901 gacagagtta agactttata tggtgttacc cctattgagt gcaatggcta ttatatcaat
     6961 ggaattgatc atgaagctgt aattcaatca aaaaacatag ataattactt tctgttcata
     7021 aaacaaaaaa tagaatcatt taattttaat gaggctttga aacaacaaat actaaaagat
     7081 atttcattat gttcatatga aggactgcat gttttaaaaa tcgaaataaa aagtgtcgga
     7141 gaagtctgtc attttgaaaa taggtattat ataagacaag gaacagctac gcatttaatc
     7201 actgacggtg aagcaattag tagtttacac agattatatt actcataatt acttaagcac
     7261 tatgaaggta tcatacacct tcatagtgta cttttttact gcgctttggg gctaaattgt
     7321 ttttgtgaat agccagaata tcgtggctac ggcggcaatg gaaatatatg atctctgctg
     7381 ccagagactg gagatgtaat tgggggcagt ttggatatcg aaaattattg tactataagg
     7441 ggtccgcttg agggggccgc ttggaaaacg gaaattttcc cacgctaaga gaattgagtt
     7501 gaacgagtgg ttacatctag gccagctaac tcactgaacg taaaggctgt acgaaatgtt
     7561 ccgaccgtcc gataaccatt tggcttactt ccgtacattt ccttgcgtag atgtacagaa
     7621 ttgtacgatt tcggacacca aaactgctgt tgtcccggtg catgaagcta ctttccgggt
     7681 tggtggtact gactttggtg ttcttaacga cgacgttttc aactctgaaa atcgcctctc
     7741 tgcacgggga tttttacccc cccatagagc cgtcatataa attcaaatta ttaactttga
     7801 tggtagaatt atcttaggtt tgataaaatt ttgagccgtc gccgtttact tcacaggatt
     7861 caatataatg gctaaatata cagtttgtga ttaccaataa actattagaa ataatgggaa
     7921 tggttgtgcc aatctctatc tggaggtctt attgcaggga acatccaccc catcgttaca
     7981 ccaatacaga attgcccccg atacaagaca tccagacatt aacctaataa aagcgcacct
     8041 tgacgagggc tttcagcagg caaagtctga gggattaaaa gtagagattt cagattataa
     8101 agaacgtctt tacctgtaca ttagaacacc tggtaataac ctaatgcaat attctggttg
     8161 cagagaaaaa taatacagtc gcgctggata cgctgacatt gacgcagtta tatgattttc
     8221 tggcgttggt cagtaaacca gctgcagcca aaacggtgta gtccctgaca caggcgccgg
     8281 tcattctgtt aactcatcca cgtatgggat gaacagttgt ttcagtttga aaccagggat
     8341 gtcagacgga tttttgctgg cgagtacgaa atccgttacg aacttaatgg ccagactatt
     8401 tatgtattgc gcctgtgaca cacacgagaa aacaggtaga ttgtgtgtga gggcaacttt
     8461 aacatagcct gcaggtgtta attcaggagc attgttatca gaccaaatat ttttcattcc
     8521 attaaatagt cttgtagggg ataaaatgaa ttacgatgaa ataacgaaaa tcactgcaga
     8581 acgtattagc gactacatga ctgaagcggt taatacagac tctaaatctg ttgcggaaat
     8641 gtttcataac gctgcatggg gagtgctatc attgtggttt gaactcgtca caaaaataga
     8701 tctggatata cataaaaaga acaggtatgc aagttatgat tttagaagaa aaatcgaaat
     8761 gcagcatgaa gagtttcaga aaatgacaga gcgtgagcaa gtgcctttat tgaaattgcc
     8821 tgaataacag agacagtgca aacgattatt tcataataac gattatgtaa tgactggtaa
     8881 gaaaataact tgattgagtt ccctttatcc agcctgatag tggataaagg gaactcaata
     8941 ataattgaat taatttatta gcttcatcgc attttttttg gtctcttcat cacttttttg
     9001 ctcttgttgt gaagaggatt gagtgactat tgaagaatta aaatcggcca tctcttttgg
     9061 aaatagcgat ctcaatatat tcacgatatc tgaaaatgtg gtttctttcg tcagcagctc
     9121 acataaaagg aaaggggtcc ggggatcttg tctgtataag gccagacctg ccgtcagtgc
     9181 ggcccggtta aggcggcttc gttccccttg cgggatactg tccagtgtat cacaaacaat
     9241 tttatctgtt tgatttacat ctggatttag tttgaaggca atggttctgc gcttgtccat
     9301 cattaattac ctatgagata cataccgtta actaaatcat attgagagtt attggttttg
     9361 aaaaaacgtt catcacgaat ctgtgtgtgt ttttttactg catcgcatat taattctgcg
     9421 ccaccgccta taaccataac atgagtataa ccagaaaatt cattgagcgt atttaataca
     9481 cgttgctcaa gtttacgaag tgcttcattc attgcttcgg tgactattga tattttgttc
     9541 tcatcattaa ttcgttgctt cagatagtta ttatcttttc tgtgaatgat tatatcgtca
     9601 gcaagatagc tacttccttt tgttctcgca agagaaaggg catcttttac tgcagatgta
     9661 accagagaga caccaagaga tgagtctccg tatattttac tgatccccga taatttcccc
     9721 attacctgag aaatatctaa tgtggtgccc ccgagatcta taattaataa agaatctaac
     9781 tcatccagtt cttgtagaac ttcataacct gccggtatag attcaggcat gacttttaca
     9841 tcttttattg tgaatgtatc cccgccattt aatgtaattt ttttccggaa gtttgctttc
     9901 ttacgctcaa tattttccgt attgggttgg ttatttctgt cgtaatactc tgtcagagga
     9961 agtgtgcaaa caatatccac ttcgcttacc ggcagaccac tggtcagtaa ggcgtgatgc
    10021 actgcaacga cattaacgtc gctgtattgc catgcgatat tggttgtgac tacagcatcc
    10081 gggctgattg gatcaaatga atactgttcg ccgttcagtg tgtagttaaa gaccttttta
    10141 tcaccaaaag agactgccca ctcgcgtttg aagctgttcg ggctaatgtg ctgtttaatt
    10201 gttccgtcgc tttcctgcca ctgtagtttg atgtttgttg aaccgtcatc aatgaatacc
    10261 aacatttata aaactcctta tggtgttttt ttggtgtgtg tttgggtatg ttttgggttt
    10321 taagtgggtt tgtttgtcaa gtttacccca tttcaaccat caatcaatga ttatttgtct
    10381 tgttttggtg ttttattggg ttgggtatgg gttgtttttg ggttttgttt ggcgggtaac
    10441 aaaagatgtc gccgggctcc tctttttact gcgccggctg acgcggcgcg gcaggaacgc
    10501 tgcctgtggt cagtgtcccg cgtccggccg ggcacgggac gggcgctttt accgctcccg
    10561 gctggcgttg gtgacagtgt acgccagccc gtcgcccttt tctgatgaac gcccttcaag
    10621 ccgctttcgc ggcatatcct cgccgtcaaa aagacgacgg ctgcggtatt ccacggtcgg
    10681 cctgacccgt taccggacgc ggtgaacagc ccacaggcag cggggaacgg gcaccacagg
    10741 ggtgccctcc cggtgccctc tgtaagagaa ggagtgctgt tatgtcccgt tttatcctgg
    10801 gtgactgcgt gcgtgttatg gccacgtttc cgggcaatgc tgtcgatttc atcctcaccg
    10861 acccgccgta tctcgtcggt ttccgtgacc gttccgggcg caccatcgcc ggcgataaaa
    10921 ccgatgaatg gctgcaacca gcctgtaatg aaatgtaccg cgtactcaaa aaagacgcgt
    10981 taatggtgag cttctatggc tggaaccgcg tcgatcgctt tatggccgcc tggaaaaatg
    11041 cgggattcag cgttgttggt cacctggtct tcaccaaaaa ctacacatcg aaggccgcat
    11101 atgtgggcta tcgccacgaa tgtgcctaca tcctggcaaa aggccgtcca cgtctgccac
    11161 aaaacccgct gccggacgtg ctgggctgga aatattcggg caatcgccat cacccgacgg
    11221 aaaagcccgt taccagcctg caaccgctga ttgagagctt cacacacccg aacgcaattg
    11281 tgctggaccc gtttgcaggc agcggctcaa cctgcgtcgc cgccctccag tccggacgcc
    11341 ggtatatcgg tatcgagctg cttgagcagt atcaccgtgc cgggcagcaa cgccttgccg
    11401 ccgtgcaacg ggccatgcag cagggggccg cgaatgatga ctggtttatg ccggaggctg
    11461 cgtaaatgaa ctatgcagga cacgaaaaac tgcgcgccga agtggcggag gtggccaatg
    11521 ccatgtgcga cctgcgtaca accatgaatg agatggagca gcggtacagc tttaatgccg
    11581 acaccctgcc ggaacgtctg gtgcgtcaga cgctgtttcg cgcaaaccgc ctcctgatgg
    11641 aggcatatac cgaaattctg gaactggaag cgtgctttaa agattgagaa ggagacgaga
    11701 atgtacggaa catgcgaaac gctatgccgg gagctggcag taaagtatcc gggagacatg
    11761 ccgctgatgc tggttatctg gtccccggaa gagattcagg cactggctga cggtatggaa
    11821 atttctctga ccggtcatga aatcaggacc gtcctggcac gcctggagga catcccggaa
    11881 gaccagcgga ttgagtccgg tatttcttcc gctgcggtga tggagattat ccgcaacgag
    11941 agcgaaaacc gcctggtgac cgtccctgct gaactgctgg cgtccctgat tcagaccgct
    12001 gaacaggcat tgtggaaacg tgaatgggcc gcccgggatc atggcctcgc cgtcccggaa
    12061 tgcgtcaccc gccgtcagga ggtggttaat caggcccgca ccctgctgaa aaacaacaca
    12121 cacgaaaacg actgatgtta tcgccgcctg ccctgcgggc ggcgatacag ggagaacgct
    12181 taatcatgaa cgaaaacagc acgctgaacg cactgatttg tcgtcacgcc cgcaacctgc
    12241 tgctggcgca gggctggccg gaagagacgg atgttgacca gcgtaacccg aagtatccgg
    12301 gctggatcag catttatgtt ctgctggatg cgccccggct ggcgacgtta cttatcaacc
    12361 gtcacggcgg cgtactgccg ccgctcctgg cctccgccat tcagaaactg accggaaccg
    12421 gggcggaact ggtactgtcc ggcagtcagt ggcagtcgct gccggtactt ccggcagacg
    12481 gaacgcaggt gtctttcccg tatgccggag aatggctgac cgaagacgaa atcagggctg
    12541 tacttgcggc ggtgcgcgat gcggtacgca gtgtcagttg ccgggtggca gaagatgcgc
    12601 ggcgtatccg ggcggcgctg accaccaccg gtcagacgtt gctgactcgc cagacgcgcc
    12661 gctttcgtct ggttgtgaag gaaagcgatc acccctgctg gctcgatgaa gatgacgaaa
    12721 acctgcccgt ggtgctcgat gccatcgtga accggggagc acgtttttcg tcggtggaaa
    12781 tgtacctggt cagcgattgt attgagcata tcctgtccag tgggctggcc tgcgatgtgc
    12841 tgcgtatacc ggatgaaccg ccccgccgct ggtttgaccg tggtgttctg cgggaggtgg
    12901 tccgggaagc ccgggccgaa atccgcagca tggcggatgc cctggcaaaa atccggaaat
    12961 gatgacgttg gcggggtaaa tccccgcctt tttcctgccg gtccccggac agagcacaaa
    13021 ggaagtcgcc gccggctccg ctttacccgg ccatgcgggg catggccttg tgggttttca
    13081 gttatgtggc ctcagcgtcg tgtgcgggct gtgccgtgcc tccatcgtag ccgggctggc
    13141 agggatgcaa gggtacgctt cgccgctgcg gtcacccggt ccctccttcc cgtctgccgt
    13201 gattttccgg tcgttcaccc gctcagattt cgcggtctca ccctccaact cccgccagcc
    13261 gtgtgcgtca ggctgcggct tcccttgcgc cctgtgcatc cccgccttat cgcccggctt
    13321 ttatggaggc acggcaccgc ccggtgtcgc ggaatatgtg aacaacggag gaaaacatca
    13381 tgcaatatgc gaaacctgtc actctgaacg ttgaagagtg cgaccgtctc tcctttctac
    13441 cgtatctgtt tggcaacgat tttctgtatg ccgaggcgta tgtgtacgcg ctggcgcaaa
    13501 aaatgatgcc ggaatatcag ggaggcttct ggcacttcat ccgcctgccg gacggtggcg
    13561 gttacatgat gccggatggc gaccgtttcc acatggtgaa cggtgcaaac tggtttgacc
    13621 gtaccgtgag tgctgatgcc gcaggcatca ttctgacttc ccttgtgatt aaccgccagt
    13681 tgtggctgta ccacgacagc ggggatgcag gactgaccca gctttaccgg atgcgcgatg
    13741 cgcagttgtg gcgtcacatc gaatttcacc ccgaatgcaa cgcgatttac gcggcactgg
    13801 actgattaac ggacggggcg gcaatgccgc ccctgtaaag gagacgagaa catgtactgt
    13861 actgttaaag aaattatccg cgaagtgctg gatacagacg tgccggacag tgaatgcgtt
    13921 tttgccgtgg tgctgacccg tggggatgtg cgtcacatag cccaggactg gagtctgaca
    13981 gacgatgagc tggaaaccgt catgcagcga ctggacgatg cctttgcgca tggtgcggat
    14041 gtcagcattg ttcacgacgt tgttcgtgag ctgatggaag aaaagcgcgc cagccgtcag
    14101 gtgacagttc cggcggtgat gctggaaaaa gtgatggcgc tggcaggcag tgaaatgaag
    14161 cgcctgtatg ccgtcgggag cgagaacggg ggcgacggtg acgcattcgt cagggaagaa
    14221 cgcgaagcaa tggacgttgt gttacaggcg ctggacgggg agcacatgtc atgaatatca
    14281 gcacagaaac ccgcgaaatt ctgcgcaatt acaaagccgt gattaatgcg cggcgtcgtg
    14341 aaatggggca gaaaccgctc accactgcgc agattgttga tgaaatctgc gattttgtgg
    14401 cgaatcagca ggctgtattc ctcggcggtc actacatcct tcagggcagc ataaacaggt
    14461 gatacagggg caggcggtgg aggccgcctg tcagcccgcg cgaaaacccc tggcaggctg
    14521 acgcctgccg gaagggaagc gggccacgct ggcgcgtcgc ccgttaccct tcccgtctgt
    14581 gatgtgtctg actcaggagt gtttctttct tatgttatgg aactgttcct gatgttgttg
    14641 ttcctttatc tgctgctctg attctgacta ctgcagtgtt gttctgtctg ccgggcgcac
    14701 cttcggctcc cggctgcctg gcggcatccg gtcgtcaggc ccgactccga caggcagctg
    14761 ctggcgcacc tgccagtctc cgccgaaccc gctggcgcgg tttcgggctg ccgctacggt
    14821 ccgatgcgtg aaaacccctg gcttgcagcg accgttccgg tcgcgccgcc tctgtcgcgc
    14881 cgtggcctgc gctcccggca tcccggcaaa aggccgccgg gatgtaaggg gcaacgccgt
    14941 ttcgcgcacg cgctctccgt cgttgcggcg ggcccctgct cattgcctgc cgggtgccac
    15001 acacccgtat gagtccctgt cgccgggggc atagacagcc acaacctgcc gcactgactg
    15061 tccagggtaa atgaacagcc cacaaaattt tttacccaaa aaccggtaaa aaattttgcg
    15121 ttctgcccag gacaggtgcg tcaggccgtg gcagtgatgc cccttgcggc gaaggttctc
    15181 aaacgggtga agttcatacc acagggaata cagcagcagg ttcccgcgaa acgtcaaaac
    15241 cgcggctccc gaaactcaac gggtgatgtt ctttaaaaat caggatttat ttcaggctcc
    15301 ggcaatacgc atttatttgt tctgtcagtc atccggctgg caggtaatga gaacgcagga
    15361 acagaaggag gaaaacaccg gagaacgtca gacgcagata tgaaaaaagc aggccgggga
    15421 ggacctgctt aatccacacc gcaaaaactg ttcgagcagt ttctgcggtt ccattcaaca
    15481 gtcataagga gtttcattta tgacggtaag tattgtttca ccttccgcag cggctgtaaa
    15541 gccccgccgt catccccgtt tcagacgcga agacatcccc gcgccggaaa ttgaccccgt
    15601 gctgaaagcc ttcgggcgac acattgcccg gagttttcac cggggacgtg gtgtacacat
    15661 ccccgccatg aaaaatacgg ctttcgggca ggtgctccgc acactcgaac tgaaacgcgc
    15721 ttttaactga tgaggtgagc cgccccgcga ggggcggcaa cagacggaag gagaacattt
    15781 tatgacatta gctgcaatca ccatgaccgc cccggaagcc gccagccctg tgcagatgta
    15841 ccgcgcgacc tactcaccgg atgacaacaa actgcgcctg tatgccgcgt cacgtcttga
    15901 cccggagacg tataaaaaag tgcatgatgc cggtttccgc tgggcaccca gacaggcgct
    15961 gtttgtcgcg ccagcctgga caccgggccg ggaagacgtg ctcctctcac ttgccggaga
    16021 gattgaggat gaagacagca cgctcgctga acgtcaggaa gcacgggcgg agcggtttac
    16081 cggatacagc ggaaagcggg ccagtgaatc cgcacaggca cttgatgaag tggaaagact
    16141 ggccgcgatg atcccgcccg gtcagcccat tcttgtgggg catcacagcg aacgccgcgc
    16201 ccgtcgtgat gcgcagcgta ttgaaaacgg catgaaacgt gccgtgatgc tctttgaacg
    16261 tgcggaatac tgggaagaac gggcgcggtc ggcactgctt cacgcgaagt ataaagaacg
    16321 cccggacgtt cgctggcgtc gtatcaaaaa aatcgaagct gatttgcgca aggctgaaaa
    16381 gaccatcgca cagtcgcaga aatatctgac gatgtggcgg gctgaatcgc tggatctgaa
    16441 tatggcaaaa ctcatcagca gtcatgacca tatcagcgcc tgtttcccgc tggatacgta
    16501 tccgcgcccg gcagaaaaaa gccagtatga agggagccgg tcgttatggt cggccctgga
    16561 tgatgacatc atcaccacgg agcaggcccg cgaaattgcg atccgctgtc atgaacggca
    16621 gattcagcat cagcaacgct gggttaacca ctatcagaac cgcctgatct atgagcgtgc
    16681 catgctggac gaaagcggcg gcgtggttac ccggacacag gattttgagc cgggcggaca
    16741 ggttttcagc cggggcgagt ggctgactat catccgcgtg aacaaaagca acggggcggt
    16801 gagttcagtc acaacgccaa attacagttt tctcgggtac agcggcacga tgaaagtgac
    16861 gcccgatcgc atcacggact acaaagcacc atcggcagaa gaggctgccg tcgccagtca
    16921 ggccgcgaag cgtccgccgg tagtcaacta tccgggggaa ggtttccggg aaatgacaaa
    16981 ggcgcagtgg gccgccctgc cccgggactg taaggccgtg cgcagtgtgg aagaagcaga
    17041 agaccacggg gcataccgct accgccgcac aatggacaat aatttccgtc tggtgaatgt
    17101 gtatatcacc gacatgaaaa tcacggaaat cccacagaaa taaggtatat ccccccggga
    17161 aatccccggg ggatgacgga gataatgata tgcacagtca gttaagagaa cgtatccggc
    17221 tgatgcgcgc aaggctggat aacgccgcgc cggttgctga aatccgggct gaatctcagc
    17281 tttttgtgag tcctgccccg atctgtgatc gcctggtgac gctggcggaa atcagcaacc
    17341 gtgatcacat tctggaaccc tctgccggca ccggggccat actgcgggcg attcgggata
    17401 ccgcgccgga ggccatgtgt gatgcggtgg agattaacag cgggctggtc cggtatctgc
    17461 gggaaaattt taacggtgtc agggtacagt gtggcgactt catggaatgg cagtcggtgc
    17521 agtattacag ccggatcatt atgaatccgc cgttcagtca cgggcaggat atccggcata
    17581 tcctgcgggc tttttccctg ttgcgtccgg ggggcgttct ggttgccgtc tgtctcaacg
    17641 ggccacgcca gcaggagaag ctgttaccgt tttctgacgt ccgcgaggag ctgccgcgcg
    17701 gcacgtttgc ttataccgat gtcccgacga tgattattcg tttgcgtgcc tgatgacaca
    17761 gggctggcgg gaggataaat gcccgtctgt ccgcgccggg aaaaaaccgc gcgccggtgg
    17821 cgctgaaagg ggccgcgctc acgcgccgcc cctttcatta cgcggacgtt ctgatggggg
    17881 cttctgtctt ttcagacctg tcatttgtct gttactgatg atgttgttgt tcctgctact
    17941 gctactgcta ctgctactgc tactgctact gctactgcta ctgttcttct tttttctact
    18001 gccctgatta ttgtctgttt tgttgttctc ctgcttatgc cttttccggg cgtccccctg
    18061 gcggggcggg ctgtcgtgaa cggagccagc gaagctgtct ccgccctggc gggcttccat
    18121 ccctgacgca aaaacccggg tttgcagcga ccggaacggt cgcgccaccc ttgtcgcgcc
    18181 gtggcctgcg ctcccggcat cccggcaaaa gacgccggga tgtaaggagc aacgccgttt
    18241 cgcaaaccgc gcttcacgtc gttgcggcgg gtccctgccc gttgttctgt ccggtgccat
    18301 tcacctgttt aagcccctgt cgccgggggc atagacagcc acaacctgcc gcactgactg
    18361 tccagggtaa atgaacagcc cacaaaattt tttacccaaa acccggtaaa aaattttgcg
    18421 ttctgcccag gacaggtgcg tcaggccgtg gcagtgatgc cccttgcggc gaaggttctc
    18481 aaacaggtga tggtgaatac cggagggaac aaaaggcagg tccccgcaaa acgtcaaaac
    18541 cgcggctccc gaaactcaac agatgatggg ggctgaaaac atcaacagaa ggagacacat
    18601 catggcagtt cgtggcatta acaaggtcat tcttgtcggt cgtctgggaa aagatccgga
    18661 agtccgttac atccccaacg ggggcgcagt ggcaaacctg caggtggcca cgtcagaaac
    18721 ctggcgcgac aaacagacgg gggaaatgaa ggagcagacg gaatggcacc gcgtggtgct
    18781 gttcggcaag ctcgcggaag tggcaggtga atatctgcgt aagggggcgc aggtctacat
    18841 tgaaggccag cttcgcaccc gtagctggga agataacggt attacccgtt acgtcaccga
    18901 aatccttgtt aaaaccacgg gcaccatgca gatgctgggg agtgcaccac agcagaacgc
    18961 tcaggtgcaa ccgcagcctc agcagaatgg tcagtcacag agtgctgacg cgacgaaaaa
    19021 agggagcgcg aaaacgaaag gccgtggacg taaggctgcg cagccggagc ctcagccgca
    19081 accaccggag ggggaggatt acgggttttc agacgatatc ccgttctgac tggcctgact
    19141 gtgataaccg ccccgtcctg cgcggggcat caccggagat atgaggatga gcgaatattt
    19201 cagaatactt cagggactgc ctgacggtcc ttttacccgc aaacaggccg aagccgttgc
    19261 cgcacagtac cggaacgtct ttatcgagga tgaccacggc gaacagtttc gcctggttgt
    19321 ccgtaataac ggaacaatgg tctggcgtac ctggaatttt gaggacggtg ccgggtactg
    19381 gatgaaccat gtcatccgtg atttcgggat ccttaagtaa gagaggtgcc ggacggggat
    19441 cacgtccggc agacattaac tacacaataa ggggatagtc atgtcagtaa caaagtctga
    19501 accaaaatct acccgtaaag caagccgtaa acctgcaaaa acgcaggaaa ctgtcctgtc
    19561 tgccctgctg gcgcagacgg aggaagtgag cgtgccgctg gcctcgctga ttaagtcacc
    19621 actgaatgtg cgcacggtgc cgtattctgc ggagtccgtc agcgaactgg ctgattccat
    19681 taagggggtc ggcctgctgc agaatctggt tgttcatgcc ctgccaggtg accgccacgg
    19741 tgtcgccgca ggtggtcgcc gactggcagc actcaacatg ctggcagagc gtggcatcat
    19801 tccggctgac tggcctgtcc gcgtgaaaat tatttcgcag gaactggcga cggccgcatc
    19861 gatgaccgag aacggtcatc gtcgggatat gcacccagcc gaacagattg ccggattctg
    19921 tgcaatggcg caggaaggca aaacacctgc acaaatcggt gatttgctgg gctattcacc
    19981 ccgccacgtt cagcgaatgc tgaaactggc tgaccttgcg cctgtcatcc tcgatgcgct
    20041 ggcagaagac ctcatcacca ccgagcactg tcaggcgctg gcgctggaga acgacaccgc
    20101 gcgtcaggtg caggtgtttg aagccgcctg tcagtcggga tggggcggta aaccggaagt
    20161 acagaccatt cgtcgtctgg tgaccgaaag tgaagtggcg gtggcaggga acagtaaatt
    20221 ccgcttcgtg ggggctgatg ccttctcgcc agatgaactg cgcactgacc tgttcagcga
    20281 cgacgagggt ggctatgtgg actgcgtggc gctcgatgcc gccctgctgg aaaaactcca
    20341 ggctgttgct gaacaccttc gggaagccga aggctgggga tggtgcgccg gacgcatgga
    20401 gcctgtcggt gagtgccgtg aggatgccgg aacataccgc tgtctgccgg agccggaagc
    20461 ggtgctgacg gaggcggaag aagaacgtct gaacgaactg atgacgcgtt acgacgcgct
    20521 ggaaaaccag tgtgaggaat ctgacctgct ggaagcagaa atgaagctga tgcgctgcat
    20581 ggcgaaggtc agggcgtgga cgccggagat gcgtgccgga agcggtgtgg tggtgtcctg
    20641 gcgttatggc aacgtgtgtg tccagcgtgg tgtgcagttg cgcagcgagg atgatgcggc
    20701 tgacgacgct gaccgcacgg aacaggtgca ggagaaagcg cccgtggagg aaatcagtct
    20761 gccactgctg acgaaaatgt cttccgaacg cacgctggca gtccaggcag cactgatgca
    20821 gcaaccggac aaatctctgg cactgctggc atggacgctc tgccctgatg aatcccctaa
    20881 tgatttttac caaaatcatt aggggattca tcagcgctct gcctgaatgt gtttggcagc
    20941 ggagcgtaca gtaaaccagc acaaatcagc ctggaatgta aacattattc gctgaccagc
    21001 gatgcgccat cggggaagga cggtgccgca ttcctggcgc tgatggcaga aaaagcccgt
    21061 cttgcagccc tgttaccgga gggatggtca cgggatatga cgacattcct gtcactcagc
    21121 caggaggtac tgttatccct gctcagtttc tgcaccgcgt gcagcatcca cggcgttcag
    21181 acccgcgagc atggtcacac gtcacgcagt ccgctggact cgctggagag cgctatcgga
    21241 ttccacatgc gcgactggtg gcagccgacg aaagcaaact tcttcggaca cctgcaaaag
    21301 ccgcagatta tcgatgccct gaatgatgcc ggactgtccg gtgctgcgcg ggacgcggag
    21361 aaaatgaaga aaggcgatgc cgctgaacat gcagagttcc acatgaaaga caaccgctgg
    21421 gtgcctggct ggatgtgtac accacgtcca caggcagaga cggaaaccac ggagtaccgt
    21481 gacgaccagg cagaagccgc ctgaccgcca gtcataaacc atttatcacg ccgccctgcc
    21541 ggagacgggg cggcagcaag ggagataccg tgatgaaaac tgaactgacc ctgaatgtat
    21601 tacagaccat gagcgcacag gaatatgaag atatccgggc tgccggaagt gatgaacgtc
    21661 gtgaactcac acatgccgtg atgcgggagc tggatgcgcc ggataactgg acgatgaacg
    21721 gcgagtatgg cagcgagttc ggcggctttt tccccgtcca ggtccgtttc acgcctgccc
    21781 acgaacgttt tcacctggcg ttatgttcac cgggcgatgt ctctcaggtc tgggtgctgg
    21841 ttctggtgaa tgccggtggt gagccgtttg cggtggttca ggtacagcgg cggtttgcac
    21901 cggaagccgt cagccattca ctggcactgg cggcgtcact ggacgcgcag gggtacagcg
    21961 tcagtgacat catccatatc ctgatggcgg aaggaggtca ggcatgagcg cacgttcaca
    22021 ggcactggtt cccctcagcg cagagcaaca ggccgcatgg cgggcggtgg cggagacaga
    22081 aaaacgccgc caccagggaa acacgctggc ggaatatccg tatgcggggg cgtttttccg
    22141 ctgtctgaac ggaagccgca ggatatcgct gtctgacctg cgatttttca tgccgtccct
    22201 gaccgcagaa gaactgcgcg gcaaccgttc tcagtggctg tatgccgtcg atgtgctgat
    22261 tgaaactcag ggcgaggtct gccttcttcc ccttcccggc gatgcagcag agcggctgtt
    22321 cccgtcggtg cggttccgtg tcagggagcg cagtcgccac aaatccgcac tggtcatgca
    22381 aaagtacagc cgccagcagg cgagggaggc agagcagaaa gcccgtgcgt accaggcgct
    22441 ggtcgctcag gctgaaatcg aactggcatt ccattcgccg gaaacagtcg gaagctggca
    22501 tgcacgctgg agtgaccggg tggcagagca tgacctggaa accctgttct ggcagtgggg
    22561 tgagcgtttt ccgtcactgg ccggaatgga acgctggcag tggcaggata tgccgttctg
    22621 gcaggttatt gcggaagcca gtcttgcagc aagagaggcc ggtcacgctg tccgtgagat
    22681 ggagcggtgg atggtgccga acaaactccg ggaggcggcg tgatgcggca acaatcacac
    22741 agattacccg taaacagcct gaatgagcgg gttattttca ggaaaagtga gtgtggtcag
    22801 cgtgcaggta tatgggctat gatgtgcccg gcgcttgagg ctttctgcct catgacgtga
    22861 aggtggtttg ttaccgtgtt gtgtggcaga aagaagatag ccccgtagta agttaatttt
    22921 cattaaccac cacgaggcat ccctatgtct agtccacatc aggatagcct cttaccgcgc
    22981 tttgcgcaag gagaagaagg ccatgaaact accacgaagt tcccttgtct ggtgtgtgtt
    23041 gatcgtgtgt ctcacactgt tgatattcac ttatctgaca cgaaaatcgc tgtgcgagat
    23101 tcgttacaga gacggacaca gggaggtggc ggctttcatg gcttacgaat ccggtaagta
    23161 gcaacctgga ggcgggcgca ggcccgcctt ttcagggctg atgctggtct gactgcactg
    23221 aagcgccttt ataaaggggc tgctggttcg ccggtggccc ctttctcctt gctggcattg
    23281 tacgggcatg aacaaccaga ctgccaggaa ggccgtttcc ctccgggaac ggggatgaac
    23341 gtgcgcctgc ggcgcccgtt cttttccccc gccttctctg tttatgactt accagaaatc
    23401 acatcacctt ccctttgatt attctctttt tccgtaagcg taaactgacc gccgtatgta
    23461 gccatcagac gagaattggt aacttagacg cccatctgat atagacggac atctaagtat
    23521 ggaattacag gactggcgaa aagaacctcg taaaaactat tcgaatgaat tcaaacttcg
    23581 tatggtggaa ctggcatcac aacctggagc ttgtgttgca cagattgcac gtgaaaatgg
    23641 cgtcaatgat aatgttattt tcaaatggct caggctctgg cagaacgaag ggcgtgtttc
    23701 gcggcgtctt ccggtaacga cctcttctga cactggcgtt gaattattac ctgtagaaat
    23761 aacgccggat gagcagaaag aacctgtggc ggccattgcg ccgtctttat ccacttccac
    23821 tcagaccaga gtcagtgcca gttcctgcaa ggtggaattc cgtcacggta acatgacgct
    23881 ggaaaatcca tcgccagagc tgctcacagt gttgatccgt gaactgaccg ggaggggaag
    23941 atgatctcac tcccatcagg tacccgtatc tggctcgttg ccggcgttac cgatatgcgt
    24001 aaatccttca acggactggg agaacaggta caacatgtgc tgaatgataa tcccttctcc
    24061 ggtcacctgt ttatcttccg tggccgacgg ggtgacaccg tcaaaattct ttgggctgat
    24121 gctgatggtc tgtgcctgtt caccaaacgc ctggaggaag gccagtttat ctggcctgcg
    24181 gtacgtgacg gcaaggtatc cattacccgc tcgcaactgg caatgctcct cgataagctg
    24241 gactggcgtc agccaaaaac atccagccgt aactcactga caatgttgta aaaaactcct
    24301 gaccgcatta taaaaacggt catgagtcag aaatacctca ttcgcatcgc agagctggaa
    24361 aggttgctct ctgagcaggc tgaagccctc cgtcagaaag accagcaact gagtctggtt
    24421 gaagagacgg aagccttcct gcgctctgca ctgacacgtg ccgaagaaaa gatcgaagaa
    24481 gatgaacggg aaatagaaca tctgcgggct cagatagaaa aactgcgccg gatgctgttc
    24541 ggtacccgtt ctgaaaaact gcgtcgtgaa gttgaactgg ctgaggctct gctgaaacaa
    24601 cgtgaacagg acagcgatcg ttacagtggg cgggaagacg atcctcaggt tccccgccag
    24661 ttgcgacagt cgcgccatcg tcgtccgtta ccggcacacc ttccccgtga aatacaccgc
    24721 ctggagccag aagaaagctg ttgcccggag tgtggcggta agctggatta tctgggggaa
    24781 gtcagcgctg aacagctgga actggtgagc agtgccctga aagtgatccg cacagaacgg
    24841 gtaaaaaaag cctgtacaaa atgtgactgt attgttgaag caccggcgcc gtcccgcccg
    24901 atagagcgtg gtatcgcggg ccccggatta cttgcccgcg tgttaacggg aaaatactgc
    24961 gaacatctgc cactgtatcg tcagagtgaa atctttgccc gccagggtgt cgaactgagc
    25021 cgggccttac tctccaactg ggttgacgcg tgctgccagt taatgacacc ggtgaatgat
    25081 gccctgtacc gttatgtaat gaacacccgc aagattcaca ctgatgacac accggtaaag
    25141 gtactggcac cgggtcagaa aaaggcgaaa acagggcgta tctggacgta tgtccgggat
    25201 gatcgcaatg tgggttcgtc atctcctcca gcggtctggt tcgcgtactc gccgaaccgg
    25261 caggggaaac acccggagca acacctccgc cccttccggg gtatcctgca ggcggatgcg
    25321 ttcacaggtt acgacaggtt gttcagtgca gaacgtgaag gtggtgcact gacagaagtt
    25381 gcgtgctggg cccatgcccg gcgaaaaatc cacgatgtat acatcagcag caaaagtgcg
    25441 acggcagaag aagcactgaa gcgaatcagt gaactgtacg ccatcgagga tgaaatacgg
    25501 ggattaccgg agtcagagcg tcttgccgtc aggcagcagc gaagcaaagt gttactgacg
    25561 tcgctgcatg aatggatggt ggagaagaat ggtacgctgt cgaaaaaatc cagactgggc
    25621 gaagcgttca gctatgtact gaatcagtgg gatgccctct gttattacag tgatgacggt
    25681 ctggcggagg cggataataa tgctgcggaa agagcgcttc gtgcagtctg tctcggaaag
    25741 aaaaacttta tgttctttgg cagcgatcac ggcggcgagc gtggagcact gttgtacggg
    25801 ctgatcggca cctgccgtct gaacggtatc gatccggaag cgtatctgcg ccatatcctg
    25861 agcgtactgc cggaatggcc ttccaaccga gttgatgaac tcctgccatg gaacgtagta
    25921 ctcaccaata aataagcgtc aatacggtgc tccgttgacg cttacctttt tcctcctgct
    25981 ctgactctga ttactgctct gactctgatt actgctgccc tgattattgt ctgttttgtt
    26041 gttctcctgc ttatgccttt tccgggcgtc cccctggcgg ggcgggctgt cgtgaacgga
    26101 gccagcgaag ctgtctccgc cctggcgggc ttccatccct gacgcaaaaa cccgggtttg
    26161 cagcgaccgg aacggtcgcg ccacccttgt cgcgccgtgg cctgcgctcc cggcatcccg
    26221 gcaaaagacg ccgggatgta aggagcaacg ccgtttcgca aaccgcgctt cacgtcgttg
    26281 cggcgggtcc ctgcccgttg ttctgtccgg tgccattcac ctgtttaagc ccctgtcgcc
    26341 gggggcatag acagccacaa cctgccgcac tgactgtcca gggtaaatga acagcccaca
    26401 aaatttttta cccaaaaccc ggtaaaaaat tttgcgttct gcccaggaca ggtgcgtcag
    26461 gccgtggcag tgatgcccct tgcggcgaag gttctcaaac aggtgatggt gaataccgga
    26521 gggaacaaaa ggcaggtccc cgcaaaacgt caaaaccgcg gctcccgaaa ctcaacagat
    26581 gatgggggct gaaaacatca gatacaggag gaattggtga tgctgccaac ttactgattt
    26641 agtgtatgat ggtgtttttg aggtgctcca gtggcttctg tttctatcag ctgtccctcc
    26701 tgttcagcta ctgacggggt ggtgcgtaac ggcaaaagca ccgccggaca tcagcgctat
    26761 ctctgctctc actgccgtaa aacatggcaa ctgcagttca cttacaccgc ttctcaaccc
    26821 ggtacgcacc agaaaatcat tgatatggcc atgaatggcg ttggatgccg ggcaaccgcc
    26881 cgcattatgg gcgttggcct caacacgatt ttccgccatt taaaaaactc aggccgcagt
    26941 cggtaacctc gcgcatacag ccgggcagtg acgtcatcgt ctgcgcggaa atggacgaac
    27001 agtggggcta tgtcggggct aaatcgcgcc agcgctggct gttttacgcg tatgacaggc
    27061 tccggaagac ggttgttgcg cacgtattcg gtgaacgcac tatggcgacg ctggggcgtc
    27121 ttatgagcct gctgtcaccc tttgacgtgg tgatatggat gacggatggc tggccgctgt
    27181 atgaatcccg cctgaaggga aagctgcacg taatcagcaa gcgatatacg cagcgaattg
    27241 agcggcataa cctgaatctg aggcagcacc tggcacggct gggacggaag tcgctgtcgt
    27301 tctcaaaatc ggtggagctg catgacaaag tcatcgggca ttatctgaac ataaaacact
    27361 atcaataagt tggagtcatt acccgttact tatccggatt atcctcagaa gtgtaaatca
    27421 gcattctcct ttgctgatgc aattgcatgc ggcaggtata cggaccggtg atgcagagcg
    27481 aatactgtcc ggcggtgaat actggcaacg tcagaagacg ctgctgacag aaagggaagt
    27541 cagttttatg aaaggactgt tcagaattgt ggatatgaag cggtggtatc tgtgtccgca
    27601 ggtacgggtc gcggatatcg tccagctgaa cgggaatatc cggccacgat cacgccagtg
    27661 gtggcagtta ttcaggatgg tgtctcagtg gcatgttgat gtggttatcg ttgagcggcg
    27721 ttcgttcagt attgttgcag cagtagagct ggatgatgcc agccatttac gaccggaacg
    27781 cagacgccgg gatattcttc tggaagaggt tctgaggcag gctggtattc cgttgctcag
    27841 aagccacgat gccagaaaac tgctgcagat gaccggagaa tggctgaata caacaggggc
    27901 tgatcagcag tccccggaac atcgtagctg acgccttcgc gttgctcagt tgtccaaccc
    27961 cggaaacggg aaaaagcaag ttttccccgc tcccggcgtt tcaataactg aaaaccatac
    28021 tatttcacag tttaaatcac attaaacgac agtaatcccc gttgatttgt gcgccaacac
    28081 agatcttcgt cacaattctc aagtcgctga tttcaaaaaa ctgtagtatc ctctgcgaaa
    28141 cgatccctgt ttgagtattg aggaggcgag atgtcgcaga cagaaaatgc agtgacttcc
    28201 tcatctggcg caaaacgagc atacagaaag gggaatccgc tttctgatgc agagaaacaa
    28261 agattatcag tggcccgtaa aagagcttcg ttcaaggaag taaaagtatt tcttgaacca
    28321 aagtataagg ccatgctcat gcaaatgtgt catgaagatg gtctgactca ggctgaagtt
    28381 ctgaccgcac tgataaaaag tgaagcgcaa aaacgatgca tgtgatgatg ggcttacatt
    28441 cttgagtgtt cagaagatta gtgctagatt actgatcgtt taaggaattt tgtggctggc
    28501 cacgccgtaa ggtggcaagg aactggttct gatgtggatt tacaggagcc agaaaagcaa
    28561 aaaccccgat aatcttcttc aactttggcg agtacgaaaa gattaccggg gcccacttaa
    28621 accgtatagc caacaattca gctatgcggg gagtatagtt atatgcccgg aaaagttcaa
    28681 gacttctttc tgtgctcgct ccttctgcgc attgtaagtg caggatggt
//
