LOCUS       NZ_CP044321            24380 bp    DNA     circular CON 13-OCT-2023
DEFINITION  Enterococcus faecium strain 15-307-1 plasmid p15-307-1_05, complete
            sequence.
ACCESSION   NZ_CP044321
VERSION     NZ_CP044321.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN08093650
            Assembly: GCF_002973755.2
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 24380)
  AUTHORS   Guerin,F., Sassi,M., Dejoies,L., Zouari,A., Schutz,S., Potrel,S.,
            Auzou,M., Collet,A., Auger,G. and Cattoir,V.
  TITLE     Cfr(D), a new plasmid-mediated linezolid resistance determinant in
            Enterococcus faecium
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 24380)
  AUTHORS   Guerin,F., Sassi,M., Dejoies,L., Zouari,A., Schutz,S., Potrel,S.,
            Auzou,M., Collet,A., Auger,G. and Cattoir,V.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2019) Rennes1 University, U1230, 2 avenue du
            Professeur Leon Bernard, Rennes 35043, France
REFERENCE   3  (bases 1 to 24380)
  AUTHORS   Sassi,M., Guerin,F., Zouari,A., Auzou,M., Fines-Guyon,M., Potrel,S.,
            Collet,A., Auger,G., Bonnet,R. and Cattoir,V.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2017) Microbiology, CHU de Rennes, 2 rue Henri Le
            Guilloux, Rennes 35033, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 09-SEP-2019
            Assembly Method :: Unicycler v. v0.4.8; canu v. v1.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 450.0x
            Sequencing Technology :: Oxford Nanopore MiniION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 10/13/2023 02:06:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,298
            CDSs (total)                      :: 3,206
            Genes (coding)                    :: 3,060
            CDSs (with protein)               :: 3,060
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 146
            CDSs (without protein)            :: 146
            Pseudo Genes (ambiguous residues) :: 0 of 146
            Pseudo Genes (frameshifted)       :: 51 of 146
            Pseudo Genes (incomplete)         :: 86 of 146
            Pseudo Genes (internal stop)      :: 31 of 146
            Pseudo Genes (multiple problems)  :: 20 of 146
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP044321.1.
            Bacteria and source DNA available from NRC for Enterococci.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..24380
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="15-307-1"
                     /isolation_source="Rectal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="p15-307-1_05"
                     /geo_loc_name="France: Corbeille-Essonnes"
                     /lat_lon="48.6103 N 2.4748 E"
                     /collection_date="2015"
                     /collected_by="NRC for Enterococci"
     gene            complement(583..741)
                     /locus_tag="CWC51_RS16080"
     CDS             complement(583..741)
                     /locus_tag="CWC51_RS16080"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_187128159.1"
                     /translation="MGYYKCFSSAVDAMNVFVRAANQGKGVQLTYNAHFSNTTSYQYND
                     YARYVIK"
                     /name="hypothetical protein"
     gene            1641..>2246
                     /locus_tag="CWC51_RS16085"
                     /old_locus_tag="CWC51_016515"
                     /pseudo=""
     CDS             1641..>2246
                     /locus_tag="CWC51_RS16085"
                     /old_locus_tag="CWC51_016515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /name="IS6-like element IS1216 family transposase"
     gene            2324..3004
                     /locus_tag="CWC51_RS16090"
                     /old_locus_tag="CWC51_016520"
                     /pseudo=""
     CDS             2324..3004
                     /locus_tag="CWC51_RS16090"
                     /old_locus_tag="CWC51_016520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(3775..>4016)
                     /locus_tag="CWC51_RS16670"
                     /pseudo=""
     CDS             complement(3775..>4016)
                     /locus_tag="CWC51_RS16670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002351084.1"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /name="DUF536 domain-containing protein"
     gene            complement(4061..4312)
                     /locus_tag="CWC51_RS16675"
     CDS             complement(4061..4312)
                     /locus_tag="CWC51_RS16675"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_187128160.1"
                     /translation="MADKTIKELAEELGVSKTAINKKVSDKNRKLWFAKNGNKFVINET
                     GQKAIKSMFLVDNANLNRKLVGEKSKPKTIKTPTKFPN"
                     /name="hypothetical protein"
     gene            complement(4328..5256)
                     /locus_tag="CWC51_RS16105"
                     /old_locus_tag="CWC51_016535"
                     /pseudo=""
     CDS             complement(4328..5256)
                     /locus_tag="CWC51_RS16105"
                     /old_locus_tag="CWC51_016535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002296860.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            complement(6407..6562)
                     /locus_tag="CWC51_RS16110"
     CDS             complement(6407..6562)
                     /locus_tag="CWC51_RS16110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016631617.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_162846310.1"
                     /translation="MKLTKLTISLVIIAGIILYFVLPANQFFLYFGIPTILIVNGVRIF
                     EQRKKM"
                     /name="hypothetical protein"
     gene            complement(6581..7150)
                     /locus_tag="CWC51_RS16115"
                     /old_locus_tag="CWC51_016545"
     CDS             complement(6581..7150)
                     /locus_tag="CWC51_RS16115"
                     /old_locus_tag="CWC51_016545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002322960.1"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="WP_002322960.1"
                     /translation="MTIKWIISIAYLVLTFAIPSLGVPSNIYFLFEHSDIFFLVLIIIL
                     FHSTFIREFKEVNLKKLFKYSFFSFSVLFLINILNTSFSEGINPNEVNGSLLLFFLNAA
                     TYGAFLEEGIFRFCMIDPQANKKQQYISILISSFLFSIVHGGGLSIFFIGIILSFVYIQ
                     TKNIWYSIVAHGFYNTIGILIYLISI"
                     /name="type II CAAX endopeptidase family protein"
     gene            complement(7150..7605)
                     /locus_tag="CWC51_RS16120"
                     /old_locus_tag="CWC51_016550"
     CDS             complement(7150..7605)
                     /locus_tag="CWC51_RS16120"
                     /old_locus_tag="CWC51_016550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002334263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LMxysn_1693 family intestinal colonization
                     protein"
                     /protein_id="WP_002322959.1"
                     /translation="MKKQLFKTFLLSTSILTFGSAITPSGAVFANENNISDIATYSDDE
                     YYYVLDEPVIQTRTWSKPQSWSIAKGSRTYLGIETHSRGTKLSVSANVFGMKIEIARNT
                     SASGKFKKYRQNARITVTYRVYRKVDNKYIRTQTSTANTQYIDYIPA"
                     /name="LMxysn_1693 family intestinal colonization protein"
     gene            <8155..8638
                     /locus_tag="CWC51_RS16125"
                     /old_locus_tag="CWC51_016555"
                     /pseudo=""
     CDS             <8155..8638
                     /locus_tag="CWC51_RS16125"
                     /old_locus_tag="CWC51_016555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611666.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /name="IS6 family transposase"
     gene            8695..9374
                     /locus_tag="CWC51_RS16130"
                     /old_locus_tag="CWC51_016560"
     CDS             join(8695..9097,9097..9374)
                     /locus_tag="CWC51_RS16130"
                     /old_locus_tag="CWC51_016560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /ribosomal_slippage=""
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_162493141.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKGPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(10156..10678)
                     /locus_tag="CWC51_RS16135"
                     /old_locus_tag="CWC51_016565"
                     /pseudo=""
     CDS             complement(10156..10678)
                     /locus_tag="CWC51_RS16135"
                     /old_locus_tag="CWC51_016565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002296856.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /name="DUF536 domain-containing protein"
     gene            complement(11126..11407)
                     /locus_tag="CWC51_RS16680"
     CDS             complement(11126..11407)
                     /locus_tag="CWC51_RS16680"
                     /inference="COORDINATES: protein motif:HMM:NF013235.3"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_315985293.1"
                     /translation="MIKFNAWNDDGNTLTKFVLFKKICIIRDKQLVIISQNPEFKGLFN
                     QLKNWTRFNLEQFTNLDSTYSKTMFRLLKQYRTQGWTEFSKEKFFLIY"
                     /name="replication initiation protein"
     gene            complement(12966..13337)
                     /locus_tag="CWC51_RS16145"
                     /old_locus_tag="CWC51_016575"
     CDS             complement(12966..13337)
                     /locus_tag="CWC51_RS16145"
                     /old_locus_tag="CWC51_016575"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_187128154.1"
                     /translation="MKNKIIKIITCLFLFGMIVGASTPLNLFPFSARGIKVEAASSRYN
                     HNHRGFTCYKMNYYVTNKMCRDLKKNYNKLKTPAQIASFIPIGGVGTWVITNAFSSAVD
                     AMNVFVRAANQGKRCTRNI"
                     /name="hypothetical protein"
     gene            13965..>14570
                     /locus_tag="CWC51_RS16150"
                     /old_locus_tag="CWC51_016580"
                     /pseudo=""
     CDS             13965..>14570
                     /locus_tag="CWC51_RS16150"
                     /old_locus_tag="CWC51_016580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /name="IS6-like element IS1216 family transposase"
     gene            14648..15327
                     /locus_tag="CWC51_RS16155"
                     /old_locus_tag="CWC51_016585"
     CDS             join(14648..14693,14693..15327)
                     /locus_tag="CWC51_RS16155"
                     /old_locus_tag="CWC51_016585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /ribosomal_slippage=""
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_187128155.1"
                     /translation="MNHFKGKQFQQDVIIGAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(16096..16635)
                     /locus_tag="CWC51_RS16160"
                     /old_locus_tag="CWC51_016595"
     CDS             complement(16096..16635)
                     /locus_tag="CWC51_RS16160"
                     /old_locus_tag="CWC51_016595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016616811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_002351084.1"
                     /translation="MADKTIKELAEELGVSKTAINKKVSDKNRKLWFAKNGNKFVINET
                     GQKAIKSMFLVDNANLNRKLVGEKSKTKNHKNTNQVSELKLLSFLEKQLNRKDIQLQEK
                     DNQIKQMQKLLDQQQQLTLQANQQIENLQEQLHLTYTEETPTTESTAFSEKKADNTQPL
                     IEKKWWQIWKSNRTNL"
                     /name="DUF536 domain-containing protein"
     gene            complement(16651..17574)
                     /locus_tag="CWC51_RS16165"
                     /old_locus_tag="CWC51_016600"
     CDS             complement(16651..17574)
                     /locus_tag="CWC51_RS16165"
                     /old_locus_tag="CWC51_016600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002296860.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_002351085.1"
                     /translation="MANEIVKYENRLNHIPLRKFNSREMNLFFSIASRVREKGVDEIIF
                     SFHDLKKLSGYTERGEQFIKDLSSTYDKLLSINAWNDDGNTLTKFVAFTKYSIIRDKQL
                     VIISVNPEFKGLFNQLKNWTRFNLEQFTNLDSTYSKTMFRLLKQYRTQGWTEFSKEKFF
                     DLLDIPKSYWNSPSNIDKFILRPIKEELTPLFKGLTIRKKYGKGRGKPVIGYRFTWKAE
                     INHADDFSKGKQEDLRIKLFNIDHNGELTREEKWRAKDRILNLPLGTHEADFKQQQQTE
                     EKQAEKRELSNKLKQDLLGNLQNLFD"
                     /name="replication initiation protein"
     gene            complement(18864..19298)
                     /gene="bacA"
                     /locus_tag="CWC51_RS16170"
                     /old_locus_tag="CWC51_016605"
     CDS             complement(18864..19298)
                     /gene="bacA"
                     /locus_tag="CWC51_RS16170"
                     /old_locus_tag="CWC51_016605"
                     /inference="COORDINATES: protein motif:HMM:NF041453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin 51 precursor BacA"
                     /protein_id="WP_002351079.1"
                     /translation="MKNKIIKIITCLFLFGMIVGASTPLNLFPFSARGIKVEAASSRYN
                     HNHRGFTCYKMNYYVTNKMCRDLKKNYNKLKTPAQIASFIPIGGVGTWVITNAFSSAVD
                     AMNVFVRAANQGKGVQLTYNAHFSNTTSYQYNDYARYVIK"
                     /name="bacA"
     gene            19926..20553
                     /locus_tag="CWC51_RS16175"
                     /old_locus_tag="CWC51_016610"
     CDS             join(19926..20335,20334..20553)
                     /locus_tag="CWC51_RS16175"
                     /old_locus_tag="CWC51_016610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001067797.1"
                     /ribosomal_slippage=""
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WP_187128156.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPYITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTGSVAKF"
                     /name="IS6 family transposase"
     gene            20607..21288
                     /locus_tag="CWC51_RS16180"
                     /old_locus_tag="CWC51_016615"
     CDS             join(20607..21215,21217..21288)
                     /locus_tag="CWC51_RS16180"
                     /old_locus_tag="CWC51_016615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /ribosomal_slippage=""
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_187128157.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKNRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(22059..22596)
                     /locus_tag="CWC51_RS16685"
                     /pseudo=""
     CDS             complement(22059..22596)
                     /locus_tag="CWC51_RS16685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002351084.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /name="DUF536 domain-containing protein"
     gene            complement(22613..23536)
                     /locus_tag="CWC51_RS16195"
                     /old_locus_tag="CWC51_016635"
     CDS             complement(22613..23536)
                     /locus_tag="CWC51_RS16195"
                     /old_locus_tag="CWC51_016635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002296860.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_002351085.1"
                     /translation="MANEIVKYENRLNHIPLRKFNSREMNLFFSIASRVREKGVDEIIF
                     SFHDLKKLSGYTERGEQFIKDLSSTYDKLLSINAWNDDGNTLTKFVAFTKYSIIRDKQL
                     VIISVNPEFKGLFNQLKNWTRFNLEQFTNLDSTYSKTMFRLLKQYRTQGWTEFSKEKFF
                     DLLDIPKSYWNSPSNIDKFILRPIKEELTPLFKGLTIRKKYGKGRGKPVIGYRFTWKAE
                     INHADDFSKGKQEDLRIKLFNIDHNGELTREEKWRAKDRILNLPLGTHEADFKQQQQTE
                     EKQAEKRELSNKLKQDLLGNLQNLFD"
                     /name="replication initiation protein"
     Typing          complement(4329..4830)
                     /name="rep_cluster_1291"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="94.347"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(10695..11623)
                     /name="rep_cluster_1291"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="94.551"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(16652..17574)
                     /name="rep_cluster_1291"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(22614..23536)
                     /name="rep_cluster_1291"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 cagtacgtcc tacggacgta tcgttcgtaa tgtgaaagta cctttaaagg tactttctac
       61 aaagctcact aaagggtttg gcaagctcta tatttgctag ccaaatacct acgtatttgg
      121 tgcaaataac cgcttgtcaa aggggcgcaa gctccccctt gaatccccct caaaacccac
      181 gctccacaat acaaaaaagg ctagcaaatg ctagccactt tgccctatat ttgctagcca
      241 aatacctccg tatttggtgc aaataaccgc ttgtcaaagg ggcgcaagct cccccttgaa
      301 tccccctcaa aacccacgct ccacaataca aaaagtggct agaaaatgct agccactttt
      361 tgtaaaattt agtatgattt atttttagct atttagagtt tttatttccg taaatacttc
      421 taaaaattgc taagataaat gctataggaa ttagataaag aatacttttt tgtaagctta
      481 tattgaaaat tagcctaaat atgaagaaca tagtgattaa aactattatt gaaataatta
      541 cagctaaaat ctttttattc atgagatagt ttcactttct gattatttta ttacataacg
      601 agcgtaatca ttgtattgat atgatgttgt attgctaaag tgagcattat atgttaattg
      661 tacacctttt ccttgatttg cagctcttac aaagacattc attgcatcaa cagcactact
      721 aaagcatttg taataaccca tgttccaact ccaccaatag gaataaaaga tgcaatttga
      781 gcaggagtct ttagcttatt ataatttttt tttttcaaat ctctacacat tttattagta
      841 acataatagt tcattttata gcaagtaaat ccacgatgat tatgattata tcgtgaactt
      901 gcagccttcc acttttatac tctagcacta aaaggaaaca gatttaacgg agtacttgct
      961 ccaacaatca taccgaacaa aaatagacaa gtaataattt taataatttt atttttcatt
     1021 gttacttctc cagatataaa atcctaggaa agcgctttct gtatatattt agaataatca
     1081 gaaaattaaa tattgtcaag agggtttatt ttataaaacg tgttatttta aaggttagta
     1141 gacataatgt acactatgcc gtagcccctc taccaatgga tagagacgct cactttgtga
     1201 tttttaattg gtctagctaa aagcaacttt ctaaagcttg atttttcgcg gttatctata
     1261 tctaattctt tgtgcatttt tatctgtcat ttttttttaa gacttgttat tttttgtaaa
     1321 atatggtaaa tttttggtag cgcttcataa gcgcgtgctt tttcaagaat aaacactcat
     1381 tattttttaa ctggctgctc gaaagagcag tctttttatt atttatccgt ctcttttaca
     1441 aacaattctt cgttaggact gttgtaataa tttgaattta atttaagttc tccgttggaa
     1501 ttgttttttc caattacgga taatagcatg gggctaaacc taatattcct agagaaatag
     1561 aacccagggt tctgttgcaa agttttaaat ctactatcaa ataaggtaga ataatagaaa
     1621 agatagcagg aggaatgacg atgaatcatt ttaaaggaaa gcaatttcag caggatgtga
     1681 ttattgtagc cgtgggctac tatcttcgtt ataaccttag ctatcgtgaa gttcaagaaa
     1741 tcttatatga tcgtggcatt aacgtttctc atacgacgat ttatcgttgg gtgcaagaat
     1801 atggcaaact actctatcaa atttggaaaa agaaaaataa aaaatccttt tattcatgga
     1861 aaatggatga aacgtacatc aaaattaaag gaaaatggca ttatttgtat cgagccatcg
     1921 atgcagatgg tttaaccttg gatatttggt tacgtaaaaa acgggacaca caagcagcct
     1981 atgcttttct taagcggtta gtgaagcagt ttgatgaacc gaaggttgta gtcacagata
     2041 aagccccctc tattacaagt gcctttaaga aactaaaaga atacggcttt tatcaaggga
     2101 cagaacatcg taccattaaa tacctgaata atttgattga acaagaccat cgtccagtaa
     2161 agagacgcaa taaattctat cgaagtttac gcactgcctc taccacgatt aaaggcatgg
     2221 aagccattcg aggattatat aagaaaaccg gttctgttgc aaagttttaa atctactatc
     2281 aaataaggta gaataataga aaaagatagc aggaggaatg acgatgaatc attttaaagg
     2341 aaagcaattt cagcaggatg tgattattgt agccgtgggc tactatcttc gttataacct
     2401 tagctatcgt gaagttcaag aaatcttata tgatcgtggc attaacgttt ctcatacgac
     2461 gatttatcgt tgggtgcaag aatatggcaa actactctat caaatttgga aaaagaaaaa
     2521 taaaaaaatc cttttattca tggaaaatgg atgaaacgta catcaaaatt aaaggaaaat
     2581 ggcattattt gtatcgagcc atcgatgcag atggtttaac cttggatatt tggttacgta
     2641 aaaaacggac acacaagcag cctatgcttt tcttaagcgg ttagtgaagc agtttgatga
     2701 accgaaggtt gtagtcacag ataaagcccc ctctattaca agtgccttta agaaactaaa
     2761 agaatacggc ttttatcaag ggacagaaca tcgtaccatt aaatacctga ataatttgat
     2821 tgaacaagac catcgtccag taaagagacg caataaattc tatcgaagtt tacgcactgc
     2881 ctctaccacg attaaaggca tggaagccat tcgaggatta tataagaaaa cccgaaaaga
     2941 aggcactctc ttcgggtttt cggtctgtac tgaaatcaag gtattattgg gaatcccagc
     3001 ttaaatcata gataccgtaa gggattttat tctttattta aaactttgca acagaaccga
     3061 acccagtacc aacacagttt tttttaacat aggttatacc tccacttttt ttaacgctac
     3121 cacttgtata cacattttaa atactagcct tcagtttatc aaatgtttaa attgaacgga
     3181 tataaatcaa aattaaattt tcaaaagttg ttctaaaaaa tctttctttt ttggaagtta
     3241 ctctaacttt ttttgcttgt ggtgcttggt atgttttctt cgccgaccgt ttaggttctt
     3301 gaccattttc tcttataagt gggattttta ccacgttgag agaaaatggt caagaacctg
     3361 ggaggcggag aatgccctta ataccaagca ccgcaagcct ttcccatact ttattcgatg
     3421 atcccacgat gatctcataa tgattctaca atgaccctac gatgatcaaa attctcaaaa
     3481 aaaataaacg aaatttcaaa cgattttttt gaaattttgt taaaatcaca tttgtttttt
     3541 tatgactttt tcaacaaaat cgattagaat ttattttgtt tttccaccaa aaattgagtg
     3601 agatttcaac ctattttaag caataagtca ccatatagtt tgatagttta caactataaa
     3661 cattgattgt ttacagttgt aaactatttt ttctttctca taaaaatttg agtgatctcc
     3721 ccatcaggta gtacaacttt ttcctctact atccgaacta acttctagaa aattttagag
     3781 attggttcta ttagatttcc aaatttgcca ccactttttt tcaataagtg gttgtgtatt
     3841 gtctgctttt tttcagaaaa ggcagttgat tcggttgttg gagtttcttc tgtataagtt
     3901 aaatggagct gttcttgtag gttctcaatt tgttggttcg cttgtagagt gagttgttgt
     3961 tgctggtcga gtaatttttg catttgtttt atttgattat ctttttcttg tagctgtata
     4021 tcttttcgat ttaactgttt ttctaggaaa gaaaggagtt ttaattcgga aacttggttg
     4081 gtgtttttat ggtttttggt tttgattttt cgccaactag ttttcgattt aagtttgcgt
     4141 tatcgactaa aaacattgat tttatagctt tttgaccggt ttcgttaatc acaaacttgt
     4201 ttccgttttt tgcaaaccaa agttttcgat ttttgtcaga aacttttttg ttaattgctg
     4261 ttttactaac tcctaattct tccgcaagtt ctttgattgt tttatctgcc ataaatactc
     4321 cttaagctta atcgaataag ttttgtaaat ttcctagtaa atcttgtttg agtttgtttg
     4381 aaagttctcg tttttctgcc tgtttttctt cagtttgttg ttgttgttta aaatcagctt
     4441 catgagtgcc taagggaaga tttagtattc gatctttagc gcgccatttt tcttctcgtg
     4501 ttaattctcc attgtgatca atattaaata attttatacg taaatcttct tgtttccctt
     4561 tggaaaaatc gtcagcatgg ttaatttcag ctttccaagt aaaacgataa ccgataacag
     4621 gtttacctcg acctttacca tattttttac gaatagttaa tcctttaaat aagggagtga
     4681 gttcttcttt aattggcctt aagataaatt tgtcaatatt tgacggaaac ttttaggaat
     4741 atcaagtaat tcatgaaagt cttcttttga aaaataagcg aaacctttgg ttctgtattg
     4801 ttttagtaat cgaaacattg tttttgaata actgctttct aattcattga attgttggag
     4861 agaatagcgc acccattctt caagattatt aagtaagggt aaggcttttt catgaacttg
     4921 tatttcagca aaaggaatat cagattttcc gtcgatttta aattgattaa ataaaacaaa
     4981 acgttcacgt tgcaaaccgt cagcacttct tctaccaaaa cgtaaatcca ttaatttgtc
     5041 atacgttgtt tctaaatcat ctatgaatcg aacatttgca gttgctttat aattgcttaa
     5101 atcttttaat tgctcgaatg taaattgtac ttttttatca cctacatcac gcattcttga
     5161 tacgatagaa aagaacaaat tcatttcgac tggtgtaaat tttcgcaacg gaattgtatt
     5221 taattcatga tgatacttta cgatttcatt agacatattt aaaatagctc ctttcttact
     5281 cgcacaagag atacacgtta tgaaatacaa aatgcctatt tatctacatc ttatattaac
     5341 atcgtcgatg tactaattca atgtacaaac agacaaaacg atgtagataa acagacaaaa
     5401 cgatgtagat aaacagacaa aacgatgtag ataaacagac aaaacgatgt agataaaagc
     5461 gtcattccct tgggagagta aggatatagc cgacggtaaa gaggtttaaa aagaggttta
     5521 aaaagagatt ataaaagagg gggacaaaat ttcccgccta aaaaaccact tcttttttct
     5581 ccaaacagat tcgcgcattt ttctcaactg ggaatcttac tccctacagt cgcttaaaaa
     5641 ggtgtgatcg ctctgctctc acattatact gcgcagtcgc ttccggctcc tttgctaaaa
     5701 atattcataa ggaactcttt gagaagctat gagccttcgt ttgagacgtt ttaagacagt
     5761 cttagtataa atcccttatc ttgttcttaa agcgccttac aggcggtcag ggcaagccct
     5821 aacaacccta aagttgtctg aatgccctct aaaattcgat ttaagcactc ttaaacctat
     5881 tcttatatat ttatatactt agacgtttca aacgtcttaa aacgcaaatt agagcttgat
     5941 aaagatattt gctcgtgtgc cgactttttt aaaagtctag gcacacgcca tgacaaagct
     6001 gaaataaact gcttcagctt tgtcatggcg gattcgctca cttgaaaaag tgttcatttc
     6061 gctcgattat tagcatatat tttttaactt tttttgctag ccaaattttg cattagttcg
     6121 ctcataaatc ccaccctttc agtacgtcct acggacgtat cgttcgtaat gtgaaagtac
     6181 ctttaaaggt acttaagggt ttggcaagct ctatatttgc tagccaaata cctacgtatt
     6241 tggtgcaaat aaccgcttgt caaaggggcg caagctcccc cttgaatccc ccctcaaaac
     6301 ccacgctcca caatacaaaa aaggctagca aatgctagcc actttttgta aagtttcgct
     6361 tgtttcacct tcggtgaaat tgttgctttg caacgatcag gtagagctac attttttttc
     6421 gttgttcaaa tattcttacg ccatttacta ttaaaatcgt aggtattcca aagtaaagaa
     6481 aaaattgatt agcaggtaat acaaaatata aaataatacc agcaataatt accaaactta
     6541 tagtaagttt tgttaatttc atgaagtatg ccaccttatc ttatatagat atcaaataga
     6601 ttaatatgcc gattgtatta taaaatccat gagcaactat ggaataccat atattttttg
     6661 tttgtatata aacaaaactt aaaataatac caataaagaa aatacttagg cctcccccat
     6721 gaacaataga aaacagaaaa gaagaaatta gtattgaaat atattgttgt tttttgtttg
     6781 cttgaggatc aatcatacaa aatcgaaaaa ttccttcttc taaaaaagct ccataagtag
     6841 cagcatttaa aaagaataaa aggagagaac catttacttc attaggattt ataccttctg
     6901 aaaaagatgt atttagaata ttgattagga ataaaacaga gaatgaaaaa aaactatatt
     6961 taaagagttt ttttagattt acttctttga attcacgaat gaaggtagaa tgaaatagta
     7021 taattattag cactaaaaaa aatatatcac tatgttcaaa taaaaaatat atatttgacg
     7081 gtactcctaa tgatgggata gcaaaggtca aaaccaagta agcaatacta attatccatt
     7141 ttattgtcat taggcaggaa tataatcaat atattgtgta tttgctgtag aagtttgagt
     7201 acgaatatat ttattatcta ccttacgata aactctgtag gttacagtta ttcttgcatt
     7261 ttgacgatat tttttaaatt ttccacttgc agaagtgttt ctggctattt cgattttcat
     7321 cccaaataca tttgcactga cagataactt tgtacctcga ctatgagttt ctatacctaa
     7381 ataagtacgg cttcctttag caattgacca gctttgaggt ttagaccaag tccttgtttg
     7441 aataactggt tcgtctaaca catagtagta ctcatcatca gaataagtgg ctatatcaga
     7501 aatgttgttc tcattagcga ataccgctcc gctaggagta atagcagaac caaaagttaa
     7561 aatagaagta gataataaaa aggttttaaa taactgtttt ttcatcaaaa tcacctcgaa
     7621 tataagatac ttaagaaaac gctttcttta tataattaga ataatcagga aatttaatgt
     7681 tgtcaagagg gtttatttta taaaagctgt tatattaaag gttagtagac ataatgtcga
     7741 ctatgccaag tagcccctct accaatggat agagacgctc actttgtgat ttctaattgg
     7801 tctagcttaa acacttcagc caatgcttga ttttatgcac ttttcttttt tcatttcttt
     7861 gtgcattttg accggtcatt ttttagagat ttgttatttt tgtgagcatt tgatatgctc
     7921 tttttatacc tcaatctctt cttttctaat gttaatgaat aggataatct catttttagc
     7981 tgctcgtgag agcagtcttt tttattattt atccgtctct tttacaaaca attcttcgtt
     8041 aggactgttg taataatttg aatttaattt aagttctccg ttggaattgt tttttccaat
     8101 tacggataat agcatggggc taaaacctaa tattcctaga gaaatagaac ccagcgttgg
     8161 gtgcaagaat atggcaaact actctatcaa atttggaaaa agaaaaataa aaatcctttt
     8221 attcatggaa aatggatgaa acgtacatca aaattaaagg aaaatggcat tatttgtatc
     8281 gagccatcga tgcagatggt ttaaccttgg atatttggtt acgtaaaaaa cgggacacac
     8341 aagcagccta tgcttttctt aagcggttag tgaagcagtt tgatgaaccg aaggttgtag
     8401 tcacagataa agcccctcta ttacaagtgc ctttaagaaa ctaaaagaat acggctttta
     8461 tcaagggaca gaacatcgta ccattaaata cctgaataat ttgattgaac aagaccatcg
     8521 tccagtaaag agacgcaata aattctatcg aagtttacgc actgcctcta ccacgattaa
     8581 aggcatggaa gccattcgag gattatataa gaaaaccggt tctgttgcaa agttttaaat
     8641 ctactatcaa ataaggtaga agactaatag aaaaagatag caggaggaat gacgatgaat
     8701 cattttaaag gaaagcaatt tcagcaggat gtgattattg tagccgtggg ctactatctt
     8761 cgttataacc ttagctatcg tgaagttcaa gaaatcttat atgatcgtgg cattaacgtt
     8821 tctcatacga cgatttatcg ttgggtgcaa gaatatggca aactactcta tcaaatttgg
     8881 aaaaagaaaa ataaaaaatc cttttattca tggaaaatgg atgaaacgta catcaaaatt
     8941 aaaggaaaat ggcattattt gtatcgagcc atcgatgcag atggtttaac cttggatatt
     9001 tggttacgta aaaaacggga cacacaagca gcctatgctt ttcttaagcg gttagtgaag
     9061 cagtttgatg aaccgaaggt tgtagtcaca gataaagccc ctctattaca agtgccttta
     9121 agaaactaaa agaatacggc ttttatcaag ggacagaaca tcgtaccatt aaatacctga
     9181 ataatttgat tgaacaagac catcgtccag taaagagacg caataaattc tatcgaagtt
     9241 tacgcactgc ctctaccacg attaaaggca tggaagccat tcgaggatta tataagaaaa
     9301 cccgaaaaga aggcactctc ttcgggtttt cggtctgtac tgaaatcaag gtattattgg
     9361 gaatcccagc ttaaatcata gataccgtaa gggattttat tctttattta aaactttgca
     9421 acagaaccga acccagtacc aatgtccata gtttttttaa cataggttat acctccactt
     9481 ttttaacgct accacttgta tacacatttt aaatactagc cttcagttta tcaaatgttt
     9541 aaattgaacg gatataaatc aaaattaaat tttcaaaagt ttttttctaa aaatctttct
     9601 tttttgaagt tactctaact tttttgcttg tggtgcttgg tatgttttct tcgccgaccg
     9661 tttaggttct tgaccatttt ctttataagt gggattttta ccacgttgag agaaaatggt
     9721 caagaacctg ggaggcggag aatgccctta ataccaagca ccgcaagcct ttcccatact
     9781 ttattcgatg atcccacgat gatctcataa tgattctaca atgaccctac gatgatcaaa
     9841 atttaaaaat aaacgaaatt tcaaacgatt tttttgaaat tttgttaaaa tcaatttgtt
     9901 tttttatgac tttttcaaca aaatcgatta gaatttattt tgtttttcca ccaaaaattg
     9961 agtgagattt caacctattt taagcaataa gtcaccatat agtttgatag tttacaacta
    10021 taaacattga ttgtttacag ttgtaaacta ttttttcttt tcataaaaat ttgaaagatc
    10081 tccccatcag gtagtacaac tttttcctct actatccgaa ctttttcttc tagaaaattt
    10141 tagagattgg ttctattaga tttttttttg ccaccacttt ttttcaataa gtggttgtgt
    10201 attgtctgct ttttttcaga aaaggcagtt gattcggttg ttggagtttc ttctgtataa
    10261 gttaaatgga gctgttcttg taggttctca atttgttggt tcgcttgtag agtgagttgt
    10321 tgttgctggt cgagtaattt ttgcatttgt tttatttgat tatctttttc ttgtagctgt
    10381 atatcttttc gatttaaagt gttttcatag gaaagaaagg agttttaatt cggaaacttg
    10441 gttctgtgtt tttatggttt ttggttttga tttttcgcca actagttttc gatttaagtt
    10501 tgcgttatcg actaaaaaca ttgattttat agctttttga ccggtttcgt taatcacaaa
    10561 cttgtttccg ttttttgcaa accaaagttt tcgatttttg tcagaaactt tttaaataat
    10621 tgctgtttta ctaactccta attcttccgc aagttctttt gattgtttta tctgccataa
    10681 atactttaag cttatcgaat aagttttgta aatttcctag taaatcttgt ttgagtttgt
    10741 ttgaaagttc ttttttttct atcatgtttt tcttcagttt gttgttgttg tttaaaatca
    10801 gcttcatgag tgcctcgcaa gggaagattt agtattcgat ctttagcgcg ccatttttct
    10861 ttagacgtgt taattctcca ttgtgatcaa tattaaataa ttttatacgt aaatcttctt
    10921 gtttcctaca tcttaattaa attcagcatg gttaatttca gctttccaag taaaacgata
    10981 accgataaca ggtttacctc gacctttacc atattttttt acgaatagtt aaacagacaa
    11041 ataagttagt aaagttcttc tttaattggc cttaagataa atttgtcaat atttgacgga
    11101 ctattccaat aacttttagg aatatctagt aaatcaaaaa aaatttttct ttggaaaatt
    11161 cagtccagcc ttgagttcga tattgtttta ataatcgaaa catagttttt gaatatgtgc
    11221 tatccaaatt agtaaattgc tctagattaa atcttgtcca gttctttaat tgattaaaaa
    11281 gtcctttaaa ttctggattt tgagaaatta taacaagttg tttatctcgt ataatgcata
    11341 tttttttgaa taaaacaaat ttagttaaag tatttccatc atcattccaa gcattaaact
    11401 taataatttg tcatacgtgc tactaagatc ttttataaat tgttccccac gttctgtata
    11461 accgcttagt tttttcaaat cgttaaatga aaaataatct catctacacc tttttcacgt
    11521 acacgtgaag caattgaaaa aataagttca tttcacgact attaaatttt cgaagaggaa
    11581 tatgatttaa tctattttca tattttacaa tttcatttga cataagtgtc tcatactttt
    11641 ataaagtatg aaataaaagt aacatacttt ataaaaatac tcaataatgt cggaaaacct
    11701 acttgaaaag cgtagaaaac ctacttgaaa agcgtagaaa acctacttga aaagcgtaga
    11761 aaacctactt gaaaaactct gaattgcttg ggagagtaag gacacagccg acataaagag
    11821 attaaaaaag agatataaaa agagattata aaagagggga ggctaatttt ccctaaaaaa
    11881 cccactcctt ttttctccaa acaggttcgc gaatttatca aaactgccaa ttttccttgc
    11941 tccctacggt tcgctaaaag gtgtgatcgc tctgctcaca ttatactgcg cagtcgcctc
    12001 cggctccttt gctaaaaata ttcataagga accctttgag aagctctgag cgttcgttta
    12061 agacatttta agacagtcct agtataaatc ccttatcttg ttcttaaaac gccttacagg
    12121 cggtcagggc aagccctaac aaccctaaaa ttgtctaaat gccctctaaa attcgattta
    12181 agcactctta aacctattct tatatattta tatacttagg cgtttcaaac gtcttaaaac
    12241 gcaaattaga gcttgataaa gatatttgct cgtgtgccta gacttttaaa aaacttagca
    12301 cacgtcatga caaagctgaa ataaactgct tcagctttgt catggcggat tcgctcactt
    12361 gaaaaagtgt ttatttcgct cgattattag catatatttt ttagcttttt tgctagccaa
    12421 attttgcatt aatttgctca taagtcccac cctttcagta cgtcctacgg acgtatcgtt
    12481 cgtaatgtga aagtaccttt aaaggtactt tctacaaaac tcactaaaag ggtttggcaa
    12541 gctctatatt tgctagccaa atacctccgt atttggtgca aataaccgct tgtcaaagga
    12601 gcgcaagctc ccccttgaat ccccctcaaa acccacgctc cacaatacaa aaagtggcta
    12661 gaaaatgcta gccacttttt gtaaaattta gtatgattta tttttagcta tttagagttt
    12721 ttatttccgt aaatacttct aaaaattgct aagataaatg ctataggaat tagataaaga
    12781 atactttttt gtaagcttat attgaaaatt agcctaaata tgaagaacat agtgattaaa
    12841 actattattg aaataattac agctaaaatc tttttattca tgagatagtt tcactttctg
    12901 attattttat tacataacga gcgtaatcat tgtattgata tgatgttgta ttgctaaagt
    12961 gagcattata tgtttcttgt acaccttttt ccttgatttg cagctcttac aaagacattc
    13021 attgcatcaa cagcactact aaaagcattt gtaataaccc atgttccaac tccaccaata
    13081 ggaataaaag atgcaatttg agcaggagtc tttagcttat tataattttt tttcaaatct
    13141 ctacacattt tattagtaac ataatagttc attttatagc aagtaaatcc acgatgatta
    13201 tgattatatc gtgaacttgc agcttccact tttatacctc tagcactaaa aggaaacaga
    13261 tttaacggag tacttgctcc aacaatcata ccgaacaaaa atagacaagt aataatttta
    13321 ataattttat ttttcattgt tacttcctcc ttagatataa aatcctagga aagcgctttc
    13381 tgtatatatt tagaataatc agaaaattaa atattgtcaa gagggtttat tttataaaac
    13441 gtgttatttt aaaaggttag tagacataat gtacactatg ccaagtagcc cctctaccaa
    13501 tggatagaga cgctcacttt gtgattttta attggtctag ctaaaagcaa ctttctaaag
    13561 cttgattttt cgcggttatc tatatctaat tctttgtgca tttttatctg tcatttttta
    13621 agacttgtta ttttttgtaa aatatggtaa atttttggta gcgcttcata agcgcgtgct
    13681 ttttcaagaa taaacactca ttatttttta actggctgct cgaaagagca gtctttttta
    13741 ttatttatcc gtctctttta caaacaattc ttcgttagga ctgttgtaat aatttgaatt
    13801 taatttaagt tctccgttgg aattgttttt tccaattacg gataatagca tggggctaaa
    13861 acctaatatt cctagagaaa tagaacccag ggttctgttg caaagtttta aatctactat
    13921 caaataaggt agaataatag aaaaagatag caggaggaat gacgatgaat cattttaaag
    13981 gaaagcaatt tcagcaggat gtgattattg tagccgtggg ctactatctt cgttataacc
    14041 ttagctatcg tgaagttcaa gaaatcttat atgatcgtgg cattaacgtt tctcatacga
    14101 cgatttatcg ttgggtgcaa gaatatggca aactactcta tcaaatttgg aaaaagaaaa
    14161 ataaaaaatc cttttattca tggaaaatgg atgaaacgta catcaaaatt aaaggaaaat
    14221 ggcattattt gtatcgagcc atcgatgcag atggtttaac cttggatatt tggttacgta
    14281 aaaaacggga cacacaagca gcctatgctt ttcttaagcg gttagtgaag cagtttgatg
    14341 aaccgaaggt tgtagtcaca gataaagccc cctctattac aagtgccttt aagaaactaa
    14401 aagaatacgg cttttatcaa gggacagaac atcgtaccat taaatacctg aataatttga
    14461 ttgaacaaga ccatcgtcca gtaaagagac gcaataaatt ctatcgaagt ttacgcactg
    14521 cctctaccac gattaaaggc atggaagcca ttcgaggatt atataagaaa accggttctg
    14581 ttgcaaagtt ttaaatctac tatcaaataa ggtagaataa tagaaaaaga tagcaggagg
    14641 aatgacgatg aatcatttta aaggaaagca atttcagcag gatgtgatta ttgagccgtg
    14701 ggctactatc ttcgttataa ccttagctat cgtgaagttc aagaaatctt atatgatcgt
    14761 ggcattaacg tttctcatac gacgatttat cgttgggtgc aagaatatgg caaactactc
    14821 tatcaaattt ggaaaaagaa aaataaaaaa tccttttatt catggaaaat ggatgaaacg
    14881 tacatcaaaa ttaaaggaaa atggcattat ttgtatcgag ccatcgatgc agatggttta
    14941 accttggata tttggttacg taaaaaacgg gacacacaag cagcctatgc ttttcttaag
    15001 cggttagtga agcagtttga tgaaccgaag gttgtagtca cagataaagc cccctctatt
    15061 acaagtgcct ttaagaaact aaaagaatac ggcttttatc aagggacaga acatcgtacc
    15121 attaaatacc tgaataattt gattgaacaa gaccatcgtc cagtaaagag acgcaataaa
    15181 ttctatcgaa gtttacgcac tgcctctacc acgattaaag gcatggaagc cattcgagga
    15241 ttatataaga aaacccgaaa agaaggcact ctcttcgggt tttcggtctg tactgaaatc
    15301 aaggtattat tgggaatccc agcttaaatc atagataccg taagggattt tattctttat
    15361 ttaaaacttt gcaacagaac cgaacccagt accaacacag tttttttaac ataggttata
    15421 cctccacttt tttaacgcta ccacttgtat acacatttta aatactagcc ttcagtttat
    15481 caaatgttta aattgaacgg atataaatca aaattaaatt ttcaaaagtt gttctaaaaa
    15541 atctttcttt tttggaagtt actctaactt tttttgcttg tggtgcttgg tatgttttct
    15601 tcgccgaccg tttaggttct tgaccatttt ctcttataag tgggattttt accacgttga
    15661 gagaaaatgg tcaagaacct gggaggcgga gaatgccctt aataccaagc accgcaagcc
    15721 tttcccatac tttattcgat gatcccacga tgatctcata atgattctac aatgacccta
    15781 cgatgatcaa aattctcaaa aaaaataaac gaaatttcaa acgatttttt tgaaattttg
    15841 ttaaaatcac atttgttttt ttatgacttt ttcaacaaaa tcgattagaa tttattttgt
    15901 ttttccacca aaaattgagt gagatttcaa cctattttaa gcaataagtc accatatagt
    15961 ttgatagttt acaactataa acattgattg tttacagttg taaactattt tttctttctc
    16021 ataaaaattt gagtgatctc cccatcaggt agtacaactt tttcctctac tatccgaact
    16081 aacttctaga aaattttaga gattggttct attagatttc caaatttgcc accacttttt
    16141 ttcaataagt ggttgtgtat tgtctgcttt tttttcagaa aaggcagttg attcggttgt
    16201 tggagtttct tctgtataag ttaaatggag ctgttcttgt aggttctcaa tttgttggtt
    16261 cgcttgtaga gtgagttgtt gttgctggtc gagtaatttt tgcatttgtt ttatttgatt
    16321 atctttttct tgtagctgta tatcttttcg atttaactgt ttttctagga aagaaaggag
    16381 ttttaattcg gaaacttggt tggtgttttt atggtttttg gtttttgatt tttcgccaac
    16441 tagttttcga tttaagtttg cgttatcgac taaaaacatt gattttatag ctttttgacc
    16501 ggtttcgtta atcacaaact tgtttccgtt ttttgcaaac caaagttttc gatttttgtc
    16561 agaaactttt ttgttaattg ctgttttact aactcctaat tcttccgcaa gttctttgat
    16621 tgttttatct gccataaata ctccttaagc ttaatcgaat aagttttgta aatttcctag
    16681 taaatcttgt ttgagtttgt ttgaaagttc tcgtttttct gcctgttttt cttcagtttg
    16741 ttgttgttgt ttaaaatcag cttcatgagt gcctaaggga agatttagta ttcgatcttt
    16801 agcgcgccat ttttcttctc gtgttaattc tccattgtga tcaatattaa ataattttat
    16861 acgtaaatct tcttgtttcc ctttggaaaa atcgtcagca tggttaattt cagctttcca
    16921 agtaaaacga taaccgataa caggtttacc tcgaccttta ccatattttt tacgaatagt
    16981 taatccttta aataagggag tgagttcttc tttaattggc cttaagataa atttgtcaat
    17041 atttgacgga ctattccaat aacttttagg aatatctagt aaatcaaaaa atttttcttt
    17101 ggaaaattca gtccagcctt gagttcgata ttgttttaat aatcgaaaca tagtttttga
    17161 atatgtgcta tccaaattag taaattgctc tagattaaat cttgtccagt tctttaattg
    17221 attaaaaagt cctttaaatt ctggattaac tgaaattata acaagttgtt tatctcgtat
    17281 aatgctatat tttgtgaaag caacaaattt agttaaagta tttccatcat cattccaagc
    17341 attaatactt aataatttgt catacgtgct actaagatct tttataaatt gttccccacg
    17401 ttctgtataa ccgcttagtt ttttcaaatc gtgaaatgaa aaaataatct catctacacc
    17461 tttttcacgt acacgtgaag caattgaaaa aaataagttc atttcacgac tattaaattt
    17521 tctcagagga atatgattta atctattttc atattttaca atttcatttg ccataagctt
    17581 ctcctacttt tataaagtat gaaataaaag taacatactt tataaaaata ctcaataatg
    17641 tcggaaaacc tacttgaaaa gcgtagaaaa cctacttgaa aagcgtagaa aacctacttg
    17701 aaaagcgtag aaaacctact tgaaaaaact ctgaattgct tgggagagta aggacacagc
    17761 cgacataaaa gagatataaa aagagatata aaaagagata taaaaagagg ggaggctaat
    17821 tttcccgcct aaaaaatcac tccttttttc tctaaacagg ttcgcgaatt tatcaaaact
    17881 gccaattcca aaccttgctc cctacggttc gctaaaaagg tgtgatcgct ctgctctcac
    17941 attatactgc gcagtcgcct ccggctcctt tgctaaaagc cgttcataag gaaccctttg
    18001 agaagctctg agcgttcgtt taagacattt taagacagtc ctagtataaa tcccttatct
    18061 tgttcttaaa acgccttaca ggcggtcagg gcaagcccta acaaccctaa aattgtctaa
    18121 atgccctcta aaattcgatt taagcactct taaacctatt cttatatatt tatatactta
    18181 ggcgtttcaa acgtcttaaa acgcaaatta gagcttgata aagatatttg ctcgtgtgcc
    18241 tagactttta aaaaagtcgg cacacgccat gacaaagctg aaataaactg cttcagcttt
    18301 gtcatggcgg attcgctcac ttgaaaaagt gtttatttcg ctcgattatt agcatatatt
    18361 ttttagcttt tttgctagcc aaattttgca ttaatttgct cataagtccc accctttcag
    18421 tacgtcctac ggacgtatcg ttcgtaatgt gaaagtacct ttaaaggtac tttctacaaa
    18481 actcactaaa agggtttggc aagctctata tttgctagcc aaatacctcc gtatttggtg
    18541 caaataaccg cttgtcaaag gggcgcaagc tcccccttga atccccctca aaacccacgc
    18601 tccacaatac aaaaagtggc tagaaaatgc tagccacttt ttgtaaaatt tagtatgatt
    18661 tatttttagc tatttagagt ttttatttcc gtaaatactt ctaaaaattg ctaagataaa
    18721 tgctatagga attagataaa gaatactttt ttgtaagctt atattgaaaa ttagcctaaa
    18781 tatgaagaac atagtgatta aaactattat tgaaataatt acagctaaaa tctttttatt
    18841 catgagatag tttcactttc tgattatttt attacataac gagcgtaatc attgtattga
    18901 tatgatgttg tattgctaaa gtgagcatta tatgttaatt gtacaccttt tccttgattt
    18961 gcagctctta caaagacatt cattgcatca acagcactac taaaagcatt tgtaataacc
    19021 catgttccaa ctccaccaat aggaataaaa gatgcaattt gagcaggagt ctttagctta
    19081 ttataatttt ttttcaaatc tctacacatt ttattagtaa cataatagtt cattttatag
    19141 caagtaaatc cacgatgatt atgattatat cgtgaacttg cagcttccac ttttatacct
    19201 ctagcactaa aaggaaacag atttaacgga gtacttgctc caacaatcat accgaacaaa
    19261 aatagacaag taataatttt aataatttta tttttcattg ttacttcctc cttagatata
    19321 aaatcctagg aaagcgcttt ctgtatatat ttagaataat cagaaaatta aatattgtca
    19381 agagggttta ttttataaaa cgtgttattt taaaggttag tagacataat gtacactatg
    19441 ccaagtagcc cctctaccaa tggatagaga cgctcacttt gtgattttta attggtctag
    19501 ctaaaagcaa ctttctaaag cttgattttt cgcggttatc tatatctaat tctttgtgca
    19561 tttttatctg tcattttttt aagacttgtt attttttgta aaatatggta aatttttggt
    19621 agcgcttcat aagcgcgtgc tttttcaaga ataaacactc attatttttt aactggctgc
    19681 tcgaaagagc agtctttttt attatttatc cgtctctttt acaaacaatt cttcgttagg
    19741 actgttgtaa taatttgaat ttaatttaag ttctccgttg gaattgtttt ttccaattac
    19801 ggataatagc atggggctaa aacctaatat tcctagagaa atagaaccca gggttctgtt
    19861 gcaaagtttt aaatctacta tcaaataagg tagaataata gaaaaagata gcaggaggaa
    19921 tgacgatgaa tcattttaaa ggaaagcaat ttcagcagga tgtgattatt gtagccgtgg
    19981 gctactatct tcgttataac cttagctatc gtgaagttca agaaatctta tatgatcgtg
    20041 gcattaacgt ttctcatacg acgatttatc gttgggtgca agaatatggc aaactactct
    20101 atcaaatttg gaaaaagaaa aataaaaaat ccttttattc atggaaaatg gatgaaacgt
    20161 acatcaaaat taaaggaaaa tggcattatt tgtatcgagc catcgatgca gatggtttaa
    20221 ccttggatat ttggttacgt aaaaaacggg acacacaagc agcctatgct tttcttaagc
    20281 ggttagtgaa gcagtttgat gaaccgaagg ttgtagtcac agataaagcc ccctattaca
    20341 agtgccttta agaaactaaa agaatacggc ttttatcaag ggacagaaca tcgtaccatt
    20401 aaatacctga ataatttgat tgaacaagac catcgtccag taaagagacg caataaattc
    20461 tatcgaagtt tacgcactgc ctctaccacg attaaaggca tggaagccat tcgaggatta
    20521 tataagaaaa ccggttctgt tgcaaagttt taaatctact atcaaataag gtagaataat
    20581 agaaaaagat agcaggagga atgacgatga atcattttaa aggaaagcaa tttcagcagg
    20641 atgtgattat tgtagccgtg ggctactatc ttcgttataa ccttagctat cgtgaagttc
    20701 aagaaatctt atatgatcgt ggcattaacg tttctcatac gacgatttat cgttgggtgc
    20761 aagaatatgg caaactactc tatcaaattt ggaaaaagaa aaataaaaaa tccttttatt
    20821 catggaaaat ggatgaaacg tacatcaaaa ttaaaggaaa atggcattat ttgtatcgag
    20881 ccatcgatgc agatggttta accttggata tttggttacg taaaaaacgg gacacacaag
    20941 cagcctatgc ttttcttaag cggttagtga agcagtttga tgaaccgaag gttgtagtca
    21001 cagataaagc cccctctatt acaagtgcct ttaagaaact aaaagaatac ggcttttatc
    21061 aagggacaga acatcgtacc attaaatacc tgaataattt gattgaacaa gaccatcgtc
    21121 cagtaaagag acgcaataaa ttctatcgaa gtttacgcac tgcctctacc acgattaaag
    21181 gcatggaagc cattcgagga ttatataaga aaaacccgaa aagaaggcac tctcttcggg
    21241 ttttcggtct gtactgaaat caaggtatta ttgggaatcc cagcttaaat catagatacc
    21301 gtaagggatt ttattcttta tttaaaactt tgcaacagaa ccgaacccag taccaacaca
    21361 gtttttttta acataggtta tacctccact ttttttaacg ctaccacttg tatacacatt
    21421 ttaaatacta gccttcagtt tatcaaatgt ttaaattgaa cggatataaa tcaaaattaa
    21481 attttcaaaa gttgttctaa aaaatctttc ttttttggaa gttactctaa ctttttttgc
    21541 ttgtggtgct tggtatgttt tcttcgccga ccgtttaggt tcttgaccat tttctcttat
    21601 aagtgggatt tttaccacgt tgagagaaaa tggtcaagaa cctgggaggc ggagaatgcc
    21661 cttaatacca agcaccgcaa gcctttccca tactttattc gatgatccca cgatgatctc
    21721 ataatgattc tacaatgacc ctacgatgat caaaattctc aaaaaaaata aacgaaattt
    21781 caaacgattt ttttgaaatt ttgttaaaat cacatttgtt tttttatgac tttttcaaca
    21841 aaatcgatta gaatttattt tgtttttcca ccaaaaattg agtgagattt caacctattt
    21901 taagcaataa gtcaccatat agtttgatag tttacaacta taaacattga ttgtttacag
    21961 ttgtaaacta ttttttcttt ctcataaaaa tttgagtgat ctccccatca ggtagtacaa
    22021 ctttttcctc tactatccga actaacttct agaaaatttt agagattggt tctattagat
    22081 ttccaaattt gccaccactt tttttcaata agtggttgtg tattgtctgc tttttttcag
    22141 aaaaggcagt tgattcggtt gttggagttt cttctgtata agttaaatgg agctgttctt
    22201 gtaggttctc aatttgttgg ttcgcttgta gagtgagttg ttgttgctgg tcgagtaatt
    22261 tttgcatttg ttttatttga ttatcttttc ttgtagctgt atatcttttc gatttaactg
    22321 tttttctagg aaagaaagga gttttaattc ggaaacttgg ttggtgtttt tatggttttt
    22381 ggtttttgat ttttcgccaa ctagttttcg atttaagttt gcgttatcga ctaaaaacat
    22441 tgattttata gctttttgac cggtttcgtt aatcacaaac ttgtttccgt tttttgcaaa
    22501 ccaaagtttt cgatttttgt cagaaacttt tttgttaatt gctgttttac taactcctaa
    22561 ttcttccgca agttctttga ttgttttatc tgccataaat actccttaaa gcttaatcga
    22621 ataagttttg taaatttcct agtaaatctt gtttgagttt gtttgaaagt tctcgttttt
    22681 ctgcctgttt ttcttcagtt tgttgttgtt gtttaaaatc agcttcatga gtgcctaagg
    22741 gaagatttag tattcgatct ttagcgcgcc atttttcttc tcgtgttaat tctccattgt
    22801 gatcaatatt aaataatttt atacgtaaat cttcttgttt ccctttggaa aaatcgtcag
    22861 catggttaat ttcagctttc caagtaaaac gataaccgat aacaggttta cctcgacctt
    22921 taccatattt tttacgaata gttaatcctt taaataaggg agtgagttct tctttaattg
    22981 gccttaagat aaatttgtca atatttgacg gactattcca ataactttta ggaatatcta
    23041 gtaaatcaaa aaatttttct ttggaaaatt cagtccagcc ttgagttcga tattgtttta
    23101 ataatcgaaa catagttttt gaatatgtgc tatccaaatt agtaaattgc tctagattaa
    23161 atcttgtcca gttctttaat tgattaaaaa gtcctttaaa ttctggatta actgaaatta
    23221 taacaagttg tttatctcgt ataatgctat attttgtgaa agcaacaaat ttagttaaag
    23281 tatttccatc atcattccaa gcattaatac ttaataattt gtcatacgtg ctactaagat
    23341 cttttataaa ttgttcccca cgttctgtat aaccgcttag ttttttcaaa tcgtgaaatg
    23401 aaaaaataat ctcatctaca cctttttcac gtacacgtga agcaattgaa aaaaataagt
    23461 tcatttcacg actattaaat tttctcagag gaatatgatt taatctattt tcatatttta
    23521 caatttcatt tgccataagc ttctcctact tttataaagt atgaaataaa agtaacatac
    23581 tttataaaaa tactcaataa tgtcggaaaa cctacttgaa aagcgtagaa aacctacttg
    23641 aaaagcgtag aaaacctact tgaaaagcgt agaaaaccta cttgaaaaaa ctctgaattg
    23701 cttgggagag taaggacaca gccgacataa aagagatata aaaagagata taaaaagaga
    23761 tataaaaaga ggggaggcta attttcccgc ctaaaaatca ctcctttttt tttctctaaa
    23821 caggttcgcg aatttatcaa aactgccaat tccaaacctt gctccctacg gttcgctaaa
    23881 aggtgtgatc gctctgctct cacattatac tgcgcagtcg cctccggctc ctttgctaaa
    23941 agccgttcat aaggaaccct ttgagaagct ctgagcgttc gtttaagaca ttttaagaca
    24001 gtcctagtat aaatccctta tcttgttctt aaaacgcctt acaggcggtc agggcaagcc
    24061 ctaacaaccc taaaattgtc taaatgccct ctaaaattcg atttaagcac tcttaaacct
    24121 attcttatat atttatatac ttaggcgttt caaacgtctt aaaacgcaaa ttagagcttg
    24181 ataaagatat ttgctcgtgt gcctagactt ttaaaaaagt cggcacacgc catgacaaag
    24241 ctgaaataaa ctgcttcagc tttgtcatgg cggattcgct cacttgaaaa agtgtttatt
    24301 tcgctcgatt attagcatat attttttagc ttttttgcta gccaaatttt gcattaattt
    24361 gctcataagt cccacccttt
//
