LOCUS       NZ_CP039449            29324 bp    DNA     circular CON 17-OCT-2023
DEFINITION  Staphylococcus aureus strain VGC1 plasmid pVGC1_1, complete
            sequence.
ACCESSION   NZ_CP039449
VERSION     NZ_CP039449.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN11431687
            Assembly: GCF_008330045.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 29324)
  AUTHORS   Fu,P.-K., Hsu,Y.-C., Hsu,P.-C., Liou,C.-H., Kuo,S.-C. and Yang
            Lauderdale,T.-L.
  TITLE     Methicillin-resistant Staphylococcus aureus Bacteriophage as a
            Virulence Factor that Elevates IL-6 and Shields MRSA from Being
            Phagocytized
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 29324)
  AUTHORS   Chen,F.-J., Wu,H.-C. and Liao,Y.-C.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2019) National Institute of Infectious Diseases
            and Vaccinology, National Health Research Institutes, No. 35, Keyan
            Road, Zhunan Town, Miaoli County 350, Taiwan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-MAR-2019
            Assembly Method                   :: Canu v. 1.6; Unicycler v. 0.4.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 445.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 10/17/2023 02:01:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,891
            CDSs (total)                      :: 2,809
            Genes (coding)                    :: 2,726
            CDSs (with protein)               :: 2,726
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 83
            CDSs (without protein)            :: 83
            Pseudo Genes (ambiguous residues) :: 0 of 83
            Pseudo Genes (frameshifted)       :: 37 of 83
            Pseudo Genes (incomplete)         :: 44 of 83
            Pseudo Genes (internal stop)      :: 14 of 83
            Pseudo Genes (multiple problems)  :: 11 of 83
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP039449.1.
            Bacteria and source DNA available from Feng-Jui Chen.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..29324
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="VGC1"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pVGC1_1"
                     /geo_loc_name="Taiwan: Taichung"
                     /lat_lon="24.186048 N 120.604496 E"
                     /collection_date="2013-04"
                     /collected_by="Pin-Kuei Fu"
                     /genotype="ST59"
     gene            232..1215
                     /locus_tag="E8M03_RS14460"
                     /old_locus_tag="E8M03_14620"
     CDS             232..1215
                     /locus_tag="E8M03_RS14460"
                     /old_locus_tag="E8M03_14620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_001181105.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFDFRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            <1235..1524
                     /locus_tag="E8M03_RS14465"
                     /old_locus_tag="E8M03_14625"
                     /pseudo=""
     CDS             <1235..1524
                     /locus_tag="E8M03_RS14465"
                     /old_locus_tag="E8M03_14625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009384749.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            2071..2220
                     /locus_tag="E8M03_RS14765"
     CDS             2071..2220
                     /locus_tag="E8M03_RS14765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000695366.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(2388..3080)
                     /locus_tag="E8M03_RS14470"
                     /old_locus_tag="E8M03_14630"
     CDS             complement(2388..3080)
                     /locus_tag="E8M03_RS14470"
                     /old_locus_tag="E8M03_14630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative immunity/bacteriocin fusion bifunctional
                     protein"
                     /protein_id="WP_000691527.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="putative immunity/bacteriocin fusion bifunctional
                     protein"
     gene            3190..3384
                     /locus_tag="E8M03_RS14475"
                     /old_locus_tag="E8M03_14635"
     CDS             3190..3384
                     /locus_tag="E8M03_RS14475"
                     /old_locus_tag="E8M03_14635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001004925.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            4501..5118
                     /gene="cadD"
                     /locus_tag="E8M03_RS14480"
                     /old_locus_tag="E8M03_14640"
     ARG             4502..5115
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            5137..5484
                     /locus_tag="E8M03_RS14485"
                     /old_locus_tag="E8M03_14645"
     CDS             5137..5484
                     /locus_tag="E8M03_RS14485"
                     /old_locus_tag="E8M03_14645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000119690.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            5641..5733
                     /locus_tag="E8M03_RS14490"
                     /old_locus_tag="E8M03_14650"
     CDS             5641..5733
                     /locus_tag="E8M03_RS14490"
                     /old_locus_tag="E8M03_14650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001791613.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(5905..6876)
                     /locus_tag="E8M03_RS14495"
                     /old_locus_tag="E8M03_14655"
     CDS             complement(5905..6876)
                     /locus_tag="E8M03_RS14495"
                     /old_locus_tag="E8M03_14655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="WP_000481279.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            7000..7419
                     /locus_tag="E8M03_RS14500"
                     /old_locus_tag="E8M03_14660"
     CDS             7000..7419
                     /locus_tag="E8M03_RS14500"
                     /old_locus_tag="E8M03_14660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418034.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_000418035.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            complement(8007..8333)
                     /locus_tag="E8M03_RS14505"
                     /old_locus_tag="E8M03_14665"
     CDS             complement(8007..8333)
                     /locus_tag="E8M03_RS14505"
                     /old_locus_tag="E8M03_14665"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_030063388.1"
                     /translation="MNTLNTVMLCIGLFFVIPSMIYLTIYYIVNTIVLYQKSKTKTSIS
                     TNIYGVKEIKYNVSPRLLRIQTKLKENRVFGAIGFVFGLFMIDIPLLYILLEFLKDFLP
                     SLSF"
                     /name="hypothetical protein"
     gene            complement(8544..9218)
                     /locus_tag="E8M03_RS14510"
                     /old_locus_tag="E8M03_14670"
     CDS             complement(8544..9218)
                     /locus_tag="E8M03_RS14510"
                     /old_locus_tag="E8M03_14670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_010775116.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYRIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQSPSTKVAMAKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            <9276..9806
                     /locus_tag="E8M03_RS14515"
                     /old_locus_tag="E8M03_14675"
                     /pseudo=""
     CDS             <9276..9806
                     /locus_tag="E8M03_RS14515"
                     /old_locus_tag="E8M03_14675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032495458.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS256-like element IS256 family transposase"
                     /name="IS256-like element IS256 family transposase"
     gene            9863..10255
                     /locus_tag="E8M03_RS14520"
                     /old_locus_tag="E8M03_14680"
     CDS             9863..10255
                     /locus_tag="E8M03_RS14520"
                     /old_locus_tag="E8M03_14680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000393259.1"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_000393259.1"
                     /translation="MEEVLIDDNMVFDIDNLKGFLNDTSSFGFIAKENNKIIGFAYCYT
                     LLRPDGKTMFYLHSIGMLPNYQDKGYGSKLLSFIKEYSKEIGCSEMFLITDKGNPRACH
                     VYEKLGGKNDYKDEIVYVYDYEKGDK"
                     /name="GNAT family N-acetyltransferase"
     gene            10256..11695
                     /gene="aph(2'')-Ia"
                     /locus_tag="E8M03_RS14525"
                     /old_locus_tag="E8M03_14685"
     CDS             10256..11695
                     /gene="aph(2'')-Ia"
                     /locus_tag="E8M03_RS14525"
                     /old_locus_tag="E8M03_14685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002390775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside O-phosphotransferase APH(2'')-Ia"
                     /protein_id="WP_001028144.1"
                     /translation="MNIVENEICIRTLIDDDFPLMLKWLTDERVLEFYGGRDKKYTLES
                     LKKHYTEPWEDEVFRVIIEYNNVPIGYGQIYKMYDELYTDYHYPKTDEIVYGMDQFIGE
                     PNYWSKGIGTRYIKLIFEFLKKERNANAVILDPHKNNPRAIRAYQKSGFRIIEDLPEHE
                     LHEGKKEDCYLMEYRYDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNE
                     YIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTF
                     LTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIY
                     NDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGI
                     IDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIK
                     NIKQEFIENGRKEIYKRTYKD"
                     /name="aph(2'')-Ia"
     gene            complement(11862..12536)
                     /locus_tag="E8M03_RS14530"
                     /old_locus_tag="E8M03_14690"
     CDS             complement(11862..12536)
                     /locus_tag="E8M03_RS14530"
                     /old_locus_tag="E8M03_14690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WP_001105960.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            complement(12616..13461)
                     /gene="blaZ"
                     /locus_tag="E8M03_RS14535"
                     /old_locus_tag="E8M03_14695"
     ARG             complement(12620..13461)
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            13568..15325
                     /gene="blaR1"
                     /locus_tag="E8M03_RS14540"
                     /old_locus_tag="E8M03_14700"
     ARG             13569..15322
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="96.92"
                     /coverage="100.0"
     gene            15315..15695
                     /gene="blaI"
                     /locus_tag="E8M03_RS14545"
                     /old_locus_tag="E8M03_14705"
     ARG             15316..15692
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            15959..16552
                     /locus_tag="E8M03_RS14550"
                     /old_locus_tag="E8M03_14710"
     CDS             15959..16552
                     /locus_tag="E8M03_RS14550"
                     /old_locus_tag="E8M03_14710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690636.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690638.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNQKDLNLLKTLYDNGTPI
                     KTIAEQWHVSRTTIYRYLNKLEDKEDEKQGEVSN"
                     /name="recombinase family protein"
     gene            16524..17966
                     /locus_tag="E8M03_RS14555"
                     /old_locus_tag="E8M03_14715"
     CDS             16524..17966
                     /locus_tag="E8M03_RS14555"
                     /old_locus_tag="E8M03_14715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mu transposase C-terminal domain-containing
                     protein"
                     /protein_id="WP_000790712.1"
                     /translation="MKNKEKYLTNFSEAKRKKATQKYNIIKPFILGEQSLSSISKSKGI
                     ALSTLYRWNKSYKEQGLKGLIYATKADKGTRKIEPKIIDEIERLALMNKRNSIATIHRK
                     TTNYCKENNFDIPSYKQIYSVIKAMPKSVIDFSHQGEKYYQNKYDLIQIRESSRPNEIW
                     QADHTLLDIFILDQKGNINRPWLTIIMDDYSRAIAGYFLSFDAPNAQNTALTLHQAIWN
                     KNDTNWPVCGIPEKFYTDHGSDFTSHHMEQVAIDLKINLMFSKVGVPRGRGKIERFFQT
                     VNQTFLEQLPGYINNNDTPSNLINFHNFEEKLRYFLIEDYNQKEHSTIHTTPISRWNSN
                     HFFPNMPSSLEQLDLLLLEIPKSRKVHSDGIHFQGFRYSNTNLAAYVGEYVLIRYNPND
                     MAEIRVFYRDEFLCTAICPEIADYSIDIKDIQHARSQRRKHLKQNIASPSTTELIKEEK
                     NCGYSPQETTKNVKKLKRYRND"
                     /name="Mu transposase C-terminal domain-containing protein"
     gene            17959..18717
                     /locus_tag="E8M03_RS14560"
                     /old_locus_tag="E8M03_14720"
     CDS             17959..18717
                     /locus_tag="E8M03_RS14560"
                     /old_locus_tag="E8M03_14720"
                     /inference="COORDINATES: protein motif:HMM:NF012464.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000164959.1"
                     /translation="MTKNQNFIETKEYKRFAEFCDACIKYQYIGICYGQPGVGKTLSSR
                     YYTNWDTIEKQVNHRGWEDLASKTTDDILSVDKIFYTAPAEKQSGKSIENRPVFQEVLN
                     FLRMGDRLIVESIDRLGRNYEEIIQTVNYLKDKEVQLMITSLPMMNEVIGNPLLDKFMK
                     DLIIQILAMISEQERNESKRRQAQGIQVAKEKGIYKGRPVLYSPNAKDPQKRLVYYRVV
                     ELLEQGKSISTIAKEVGITRQTIYRIKNSK"
                     /name="recombinase family protein"
     gene            18778..19092
                     /gene="arsR"
                     /locus_tag="E8M03_RS14565"
                     /old_locus_tag="E8M03_14725"
     ARG             18779..19089
                     /name="arsR"
                     /gene="arsR"
                     /gene_name="As(III)-sensing metalloregulatory
                     transcriptional repressor ArsR"
                     /tool="amrfinderplus"
                     /drug_class="ARSENIC"
                     /identity="99.04"
                     /coverage="100.0"
     gene            19089..20381
                     /gene="arsB"
                     /locus_tag="E8M03_RS14570"
                     /old_locus_tag="E8M03_14730"
     ARG             19093..20378
                     /name="arsB"
                     /gene="arsB"
                     /gene_name="arsenite efflux transporter membrane subunit
                     ArsB"
                     /tool="amrfinderplus"
                     /drug_class="ARSENIC"
                     /identity="99.77"
                     /coverage="100.0"
     gene            20399..20794
                     /locus_tag="E8M03_RS14575"
                     /old_locus_tag="E8M03_14735"
     CDS             20399..20794
                     /locus_tag="E8M03_RS14575"
                     /old_locus_tag="E8M03_14735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-dependent arsenate reductase"
                     /protein_id="WP_000358995.1"
                     /translation="MDKKTIYFICTGNSCRSQMAEGWGKEILGEGWNVYSAGIETHGVN
                     PKAIEAMKEVDIDISNHTSDLIDNDILKQSDLVVTLCSDADNNCPILPPNVKKEHWGFD
                     DPAGKEWSEFQRVRDEIKLAIEKFKLR"
                     /name="thioredoxin-dependent arsenate reductase"
     gene            21174..21467
                     /locus_tag="E8M03_RS14580"
                     /old_locus_tag="E8M03_14740"
     CDS             21174..21467
                     /locus_tag="E8M03_RS14580"
                     /old_locus_tag="E8M03_14740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_000726502.1"
                     /translation="MKKKFVSSCIASTILFGTLLGVTYKAEAATVHVAGGVWSHGIGKH
                     YVWSYYSHNKRNHGSTAVGKYSSFSGVARPGVQSKASAPKAWGGNKTFYSLH"
                     /name="lactococcin 972 family bacteriocin"
     gene            21542..23476
                     /locus_tag="E8M03_RS14585"
                     /old_locus_tag="E8M03_14745"
     CDS             21542..23476
                     /locus_tag="E8M03_RS14585"
                     /old_locus_tag="E8M03_14745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001670421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="WP_000713731.1"
                     /translation="MKKFKLFLDFSTLLLISGLLFLFFFKENEEIIPESSNILTISNWD
                     KSNSKSKVLDVIESGAKNQNIQIIKSVKDFDNKKEFFVFNSKRNNSDFIRNKTSLLTPS
                     DLLNREIKGKYYIIGEHFNVEELTSELKKAGLTSEVEYINRNILFFELVIDNDLLVPFI
                     FLGVLYLLYFLYDRGYNLKFYAIQKLHGFSTTRIIFHNIHIKIIYWLVLTTIFFIANIL
                     IIHIANLELDFLMFIRRFIVLLFVFACITTLLWLISYSLLLKLSIPLTLKGKKGYKFSI
                     FMGTFTKCIMVLILSFLLAQNLNAYTKLKNIYDSEKIWQKLDNYYTLEISPNIRNSEEK
                     QILETNIYNLIKKSEQLGGLLLKNNNIANPDKNNYIPENGNVFFINNNFLNFYKNINHD
                     FKMIDNHSDKINVFIPPRLQYQKSEIQKNHQGWIDFQKQQNKKVDVQVLSKNVSVFSFD
                     RTTNLKFGYLDSPIVMLLTPDDLTGDFYLAAVSQGGYLFKDLDTLKQLLKDNHLEEEIS
                     GITNYKDSVLNELNETKTKMIITIVTIIINVFILLIATVFETIQYFSWNKKQLLLRKIH
                     GYSLFSSNVRYLTISILLSIMLAYTTHILFGSKILLFIIMSIAIIQHLLQIAYIKYLEK
                     YFKDLMREI"
                     /name="bacteriocin-associated integral membrane family
                     protein"
     gene            23480..23791
                     /locus_tag="E8M03_RS14590"
                     /old_locus_tag="E8M03_14750"
     CDS             23480..23791
                     /locus_tag="E8M03_RS14590"
                     /old_locus_tag="E8M03_14750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YxeA family protein"
                     /protein_id="WP_000831610.1"
                     /translation="MKRTLIIVTIVLLIIILSLLLVRNEHLDRFNPLLKEKVSYAKVPK
                     DTQDYRNITVYSKNGEKKSYKLDFLGYDPTKEYVKVNHKGKYVRSIEYITKDIPSFLK"
                     /name="YxeA family protein"
     gene            23803..24429
                     /locus_tag="E8M03_RS14595"
                     /old_locus_tag="E8M03_14755"
     CDS             23803..24429
                     /locus_tag="E8M03_RS14595"
                     /old_locus_tag="E8M03_14755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000593103.1"
                     /translation="MIKLENVFVKKGNKNILDGCNFNFEKGKSYALVGESGAGKSTLLN
                     IIAGFEDVSQGSIYIEDKLLKKKVDFYRYTLGYLFQNFALLENQTISQNLDLALKFKKN
                     KKDNMNLKKEVLKKVGLDLDIKRIVSSLSGGEQQRVALARLILKDPKIILADEPTGSLD
                     TKNGKIVIDLLLKLLDENKTMIVVTHDLELAKRFDVIVNISELRS"
                     /name="ABC transporter ATP-binding protein"
     gene            24667..25310
                     /gene="mobV"
                     /locus_tag="E8M03_RS14865"
                     /pseudo=""
     CDS             24667..25310
                     /gene="mobV"
                     /locus_tag="E8M03_RS14865"
                     /inference="COORDINATES: protein motif:HMM:NF013258.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MobV family relaxase"
                     /name="mobV"
     gene            25377..25877
                     /locus_tag="E8M03_RS14610"
                     /old_locus_tag="E8M03_14770"
     CDS             25377..25877
                     /locus_tag="E8M03_RS14610"
                     /old_locus_tag="E8M03_14770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000273007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000273007.1"
                     /translation="MYEIKTKNVGGWFHKEKQETGNIVITKTYFEKYTKQIKAAQMILD
                     DYEWIKSGKSLKKSEKQNESLVNELTSVHMENEKLVEEFNDLAQRYNYLLSENEKKDKE
                     LNYTLKLFNQVFKIIKSMMKEERYHTLINHIDNHLDNSKIREVMTIDNNDEQFFKKKYQ
                     AQE"
                     /name="hypothetical protein"
     gene            26239..27099
                     /locus_tag="E8M03_RS14620"
                     /old_locus_tag="E8M03_14780"
     CDS             26239..27099
                     /locus_tag="E8M03_RS14620"
                     /old_locus_tag="E8M03_14780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_000145511.1"
                     /translation="MTGETVVYKNEMNLVPLRRFTATEINLFFAMCNKLKEQDTNTLRL
                     SFDELKKLSNYSPETRNINRFANDLDNVYKKMLNLTIRYEDDDVIERFVLFNHYRIHKR
                     EQYLEISTSSNLKHILNSITNNFTKFELKEMTRLKSTYSKNMFRLLKQYKHTGYLKIHI
                     DDFKNRLDIPKSYRMTDINKNVFKPIIIELGSIFNNLTINKIKAKKGRKIEWIEFTFDA
                     EKRIHNKRQPQMSKIDKSRQYVRREKTPKWLEERSYEKQPQKDYDPQLEKEREDFLKQL
                     ELNWE"
                     /name="replication initiation protein"
     gene            27186..27527
                     /locus_tag="E8M03_RS14625"
                     /old_locus_tag="E8M03_14785"
     CDS             27186..27527
                     /locus_tag="E8M03_RS14625"
                     /old_locus_tag="E8M03_14785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761340.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000761344.1"
                     /translation="MKLAEAIKEQRELKRWSQEELANILKVSRQSVSKWESAKNYPSLD
                     ILIAMSDLFGISLEHLIKGDARFKKVILEGNYRESNRAPSIVDFLYDFWWLFFPVAGFL
                     VWAIHSFMG"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(27742..27837)
                     /locus_tag="E8M03_RS14630"
                     /old_locus_tag="E8M03_14790"
     CDS             complement(27742..27837)
                     /locus_tag="E8M03_RS14630"
                     /old_locus_tag="E8M03_14790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001002795.1"
                     /translation="MNEILVHIMTTAISGCLVTLFGYWLHKRDKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            27986..28171
                     /locus_tag="E8M03_RS14635"
                     /old_locus_tag="E8M03_14795"
     CDS             27986..28171
                     /locus_tag="E8M03_RS14635"
                     /old_locus_tag="E8M03_14795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000466617.1"
                     /translation="MFGDQRQEATKYVIKEGYQDIYFLNKNGEWYYFEVRSAWRGKHII
                     RVKDGLLGWRKEIVTE"
                     /name="hypothetical protein"
     gene            complement(28387..29130)
                     /locus_tag="E8M03_RS14640"
                     /old_locus_tag="E8M03_14800"
     CDS             complement(28387..29130)
                     /locus_tag="E8M03_RS14640"
                     /old_locus_tag="E8M03_14800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_000843732.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     ARG             20400..20791
                     /name="arsC"
                     /gene="arsC"
                     /gene_name="thioredoxin-dependent arsenate reductase"
                     /tool="amrfinderplus"
                     /drug_class="ARSENIC"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             10257..11692
                     /name="aac(6')-Ie/aph(2'')-Ia"
                     /gene="aac(6')-Ie/aph(2'')-Ia"
                     /gene_name="bifunctional aminoglycoside N-acetyltransferase
                     AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             10257..11695
                     /name="AAC(6')-Ie-APH(2'')-Ia bifunctional protein"
                     /gene="AAC(6')-Ie-APH(2'')-Ia bifunctional protein"
                     /gene_name="aminoglycoside bifunctional resistance protein"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(12617..13461)
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="95.02"
                     /coverage="100.0"
     BGC             16174..26467
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          1581..1728
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          233..1215
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.187"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          1347..1516
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="93.605"
                     /coverage="91.0"
                     /evalue="1.04e-65"
     Typing          26240..27099
                     /name="rep_cluster_2214"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(28388..29130)
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          24668..25041
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="99.2"
                     /coverage="100.0"
                     /evalue="1.03e-73"
ORIGIN
        1 atttaaagtg ctataataaa cttaatataa caaaaacccc aactactggt aatagtcggg
       61 gtttggtaat aaaacgttta gaaactgttt atttatataa ttttcgatac ttgtattata
      121 taatgaataa tatcttagtg caagcaccta aatcattaaa taaatgtaaa gctaaataaa
      181 aacgttttat tacctcttac caaactaaaa tatggaaaga ggttttttgt catgcaaaat
      241 caatatttta cagtgcaaga aaattacaaa gaaagatttt atcaaatccc taaagtattc
      301 tttaccagtg aaaattataa aaatctaact aatgatatga aaatagccta tgctatctta
      361 cgtgatcgct taaatttatc tattaaaaat agctgggttg atgaagatgg taacatttac
      421 tttgtttatt caaatgaaaa gctaatggaa atcttaaatt gtaaaaaaga aaagttaaca
      481 aaaataaaaa aagggttaga aaacgatggt ctactcattc aaaaacgacg tggtttaaat
      541 aaaccaaata ttctatattt aatgaaacct attgtcacag aacgtgatat ttacaaaata
      601 gaaaaagaag aaaacgatgt tgaaccttac ggcgagaagg aagttcgaaa atcgaacgtc
      661 cagaagttcg attttcgaac ttccagaagt tcgaaaatcg aacgtccaga agttcgaaaa
      721 tcgaacacta atgatactga ctttaatgac attgacttta atgatactga gaataatgat
      781 atgaatgact tgaatgatat aaagtacaaa aatgaaatta gtaatcattc aaatcattca
      841 aatcaattta cacataattt tgatgataaa gaaatgctat tgcaagaatt cccagaacaa
      901 ctaactaatt atttattaaa atatgattat agagatttag aaatcataaa ggctgttatt
      961 cttaaagcaa aaaaatcatt taattcaagg catgaagata tgcattacat gttagaggac
     1021 attgaggatg aaatattaac ttctttaaaa agacttaaaa aagctataca tgatagggga
     1081 gttaaaggcc aaaaggaaac aatcaagtca atgcaagctt atttaatgca aacaattcta
     1141 actgaacttg aagaaacaca tgccctttat atgcgccgta aaaacatgaa acaatataat
     1201 atctttaatc aataattcaa atgattttat aacactcgaa gagacatcaa aatattccgt
     1261 taaatcatct gactttttaa ctgatgacga cgaaaaaaat caagaaattg taagtgattt
     1321 agaaaaaggt ttgtatcgaa aacgtatgtt aagttatggt ggattgctta aacaaaagca
     1381 taaaatttta aacttagacg atgccgaaga tggtaatttg attaatacaa gtgatgaaga
     1441 taaaacgaca gacgaagaaa aaaagcacat tcaattaccg caatttggaa tttcgaaaag
     1501 caaaattatt atttaagaca ttagtgataa ctgatgtctt tttttattgt ttttctgtaa
     1561 aaaagtgctg tcttattttt gtgacaaatg ctgtatgtag tgtcacaaaa gtgtgacact
     1621 acagctttgt atgatatcac tttaaaataa cttaaaaccc ttggaatgtc tggccttgcc
     1681 agatctatca tttttgaatg atagcaaatt tcccttatgc tcttacggag attttagagt
     1741 taaattaaaa tttctaagtt tttgataaga aaagccctgc aggaatttag aaaaacatgg
     1801 ggaagtttta aagtatttta tgctaatttt taaatttgca tgtaaatggg cagtatctaa
     1861 aaaattagtc actgattttg ctgaaatttt tgtttgtgaa attagcatat atttatttgg
     1921 ctcatatttg cgttttaaga gactgtatag atttttaagt acaaaaccta tatgatttgc
     1981 ctctaagtct tcaaaatgcc tcttaaaatc caaaataaaa gtgtttaata ttgtaataag
     2041 gattgctatt tttataaaag gagagatatc atgaagatta aaactttcgc tacttttact
     2101 catcgtcaat tagataaaca agttaatagg tttttaaaga atgatattca tgtattagaa
     2161 attcaaacac acagtaattg gttatatatt tcagctattg ttttttatga ggataaataa
     2221 ggaacatcgt atttatgccg aaaaaattta ttgatgttga gaagaaccct taactaaact
     2281 tgcagacgaa tgtcggcata gcgtgagcta ttaagccgac cattcgacaa gttttgggat
     2341 tgttaagggt tccgaggctc aacgtcaata aaacaattgg aataaaatca acctacagag
     2401 catccagctg caaatgcagt tccgcaaact gcttcacata caccgccggc tattggattt
     2461 acgattgccc atactccaca gtagtgagca catgcataaa gtccagccat actacaagcg
     2521 aatgctttgc cgttccattt gaatcctgca tatgttaccg gtctgttttt atcaactttt
     2581 tcagccttat attcaacgta atttttgtta ataagtattt ttccctcttt gttttcagtc
     2641 atacttcttt tttcggcaat gaattttgtg atttttttgt tgtagttatc atatattgtt
     2701 tcagaaacta caatttcttt tgttttttca tttttataag cgttattagc tatgtagcca
     2761 tatgcatttt tatcatttgc ttctgtagct agatatttta atttagaatt tttgtcttct
     2821 agctttattt ttttaaatcc ttcttttttc atttgctttt cgaatttttg catatcttca
     2881 tttttatttt gcaattgttc tagaaaactt atttctttct tggtcatttg tgatacttcg
     2941 atgtttttgc ttttcaattt ttctttttga ttttctagta aagaactttt ttgttcttca
     3001 tttgcgtaag cattagaaaa attcgcgcta aataccagta ggaacaagga aattattgaa
     3061 aataatttta taattttcat ttgatacctc caagataata agatatttta attgtataag
     3121 taagcgcttt ataaaatcaa tatttatttt aatatattta taaacatatt tttgaaagga
     3181 gtctatttta tgaatgaaaa tttagaaaaa tatataaaaa gtttgccact tttaggtttg
     3241 ttaattagta ttttgttaat tgttttattc ttttttattt tagatgttga tgaagattta
     3301 ttcgtggttt ttttatactg tttattgcct ttgatagtta atttgtctat ttatggtttt
     3361 tatgtttttg ttaaaagaaa gtaagattat gaataatttt gtttttaatt tgtatgcttt
     3421 gagggggttg gaaaacggta ggtgtataga ttagatttct tgtttttttg aaacgagtgt
     3481 gaacgagttt cttcttgtct tgatttttga taaaaacgcc ctacaggaat ttagaaaaac
     3541 gtggggaagt tttaaagaat tttatgctaa tttttaattt gcatgtaaat gggcagtgtc
     3601 taaaaatagt tattgttttt gctcaaattt ttgtttttga aaatagcata tatttatttg
     3661 gctcatattt gcgttttaaa agcatatata agttttagat ataaaactat atgaatcacc
     3721 cctaaatctt taaaatgccc tcttaaaatt caaaataagg gcataaaaaa taaaagctac
     3781 cccagataaa gtgaggtagc tttttctttc atacggtcta tttatttttc tttcgacgcc
     3841 gtatcgtcga tgtaattcaa aaaagttatg ggctataaat ctacatcact ttttcaagaa
     3901 tgtagtagca atattcaacg caaattaatt tttataactg ctcggaatat ctcaagccgt
     3961 ttctttaatt ttgaaataaa aaaatcgacg aaggtcgatt acgtttttgc acatgtcgat
     4021 ttatccgacg tataagtgcg cccttacggg atttaactag attataacga cgaattttag
     4081 acctgtaaag caataacaat taggtctacc aggtagataa agtgtacaaa gtagaaccga
     4141 aaaagttatt tattttgaag atttttcgta gatataattt gctaataaac ttcctaaaac
     4201 tgaataaaga aaaatagtta aactcatgta atcactccat aattctgaag tgtctccatg
     4261 tctacgcata gacatgcatt tatgtcgaga aaatttattg tgcgttgaga agaaccctta
     4321 actaaacttg cagacgaatg tcggcatagc gtgagctatt aagccgacca ttcgacaagt
     4381 tttgggattg ttaagggttc cgaggctcaa cgtcaataaa gcaattggaa taaagcacct
     4441 atgattattt aaaaatataa gttataatac attcaaaaat atttttgaat gaggtgtatt
     4501 atgattcaaa cggttgttgc tgctgctgtt ctttatattg ctacagcagt tgatttatta
     4561 gtaattttat taatattttt tgctagagca aagactagaa aagaatatag agatatttat
     4621 gttggtcaat atttagggtc tattatttta atattagtta gtttgttttt agcttttgta
     4681 ttaaattatg ttccagaaaa gtggatatta ggtttattgg gtttaatacc aatttatctt
     4741 ggaattaaag tggctattta tgatgattgt gaaggagaaa agagagctaa aaaagaattg
     4801 aatgaaaaag gattgtctaa attagttggt acggttgcaa ttgttacgat agcaagttgt
     4861 ggcgccgata atattggttt atttgttccg tattttgtga cattaagtgt tactaattta
     4921 ttacttactc tgtttgtctt tttaatttta attttcttct tggtgtttac tgcacaaaaa
     4981 ttagctaata ttccaggaat tggagaaatt gttgagaaat ttagtcgttg gattatggct
     5041 attatttata tagctttagg tttatttatt attattgaaa atgacactat tcaaacaatt
     5101 ttaggattta tattttaatt tagggtgtga ttttatatga gttatgaaaa tacttgtgat
     5161 gtgatctgtg tacatgagga taaagttaac aatgctttaa gttttttaga agatgataaa
     5221 tctaagaaat tacttaacat tttagaaaaa atttgtgatg agaagaaatt gaaaatcata
     5281 ttatctttga ttaaagaaga tgagttgtgt gtttgtgata tttctttgat attgaaaatg
     5341 agtgttgctt caacttcaca tcatttaagg cttttatata aaaatgaggt acttgatttt
     5401 tataaagatg gaaagatggc atattatttt attaaagacg atgaaataag agagtttttc
     5461 tctaaaaatc atgagggttt ttgaaacgag tttcttcttg tcttgatact ataaaaaaca
     5521 aagttatata acataagacg acttatcgga agtagatatg cttgtatatt cacagatggt
     5581 ataataatag agtcgcctat ctctcaggcg tcaattgacg aagagaggag gtgcattact
     5641 ttgctaatca ttttcgttca catcatagca ccagtcatca gtggctgtgc tgttgcgtat
     5701 tatacttatt ggcttagtaa acgcaacaaa taattaatag gcgactttat aagccagcat
     5761 cgaaaaaatc cccacactac tgcaatagtg tggggattgg tgcattaatt gttaatcatt
     5821 ttcgttatat aaattataac actggttagt agagaaatgc aaaatgattg aattaatagt
     5881 aaatgtatta atgaatactc acacttatac ttttaaaata gttcttccta aatgttgtcc
     5941 ttttaaaagc tgatctatcg ttttatagaa ttcttcaaat ccaatttcat tgtatagaag
     6001 tgaatttcct atattccatt catttgctaa cttactccat atatcttcac ggatattatg
     6061 atcaacatat acagaatcaa tgccaattaa tttaatacct ctaagaataa acggtaatat
     6121 attagcgtta agtgaatttc ctgctacatt tccacataca gtagcaacac cttgataatt
     6181 tagacgtttt aaaccgtata atgttacatt actccccact gtatctaaga aataatcaaa
     6241 aatacctttt ttaagcggtt tattatcatc ttcaattatt attacttgtt ttgcacctaa
     6301 tttttttgcg atttctattt gcttttcttt tcttacgata gcagtgatat tttcatatcc
     6361 aattttatgt aaaatttgta tagcaacact gcccacacca cctgtagccc cagacactaa
     6421 aatttcaggt tgtgatttga tattcattcc atatttttct agttcaaaaa ttgataatgc
     6481 tgccgtaaaa ccggctgtgc catataccat agactcttta atagacattt cttggggaat
     6541 aggaacaatc cactctccag gcacttgtgc atattctgaa aatccacctg tatgtgtcac
     6601 gccaacatca taaccagtaa ctaatacatt atcgccttct ttaaacttat cattcgaact
     6661 tgattcaaca atacctgcaa aatctatacc aggaatcata ggataatctc taattacacc
     6721 gcctttatat tgtaaagcta gcatatcctt ataatttatt gaagagtata ccacttttac
     6781 taatacatca cccttcgata aatgagattc atcaactttt tctactttat aactaacatt
     6841 tgatgcactt tttctcacta ctaccgcatt gaacatttat tagccttctt tcacaattgt
     6901 tttgtagaag tatgtttttg ttgcaaaact attttcctac aaaacttatc atgatatgat
     6961 aagcgagtca atactaatga tttaagagag gttttagttg tggaattaga taattgtata
     7021 aattatttgt tgagtacttc tcagaataga gtttttaaac attttaaaag tttattaagt
     7081 ccctataata ttactccagc agaatatggt gttttgaatt gcttgattaa tagtaatttg
     7141 aatacaccta aagcgattgg taatacttta aatttagaac cttcaacaat atctggaata
     7201 ttagataaga tgtccaaaaa ggatctaata acacgtcaaa ctgataatga aaatagaaga
     7261 actgtgctaa taaacagtac aaataaagca aaagacttat ggccaacatt agaaaagaaa
     7321 gcctatcaac ttaataatca ttacttcgct aatttaacta atgaagaaac tgtagtgttt
     7381 aaaaagatat tactaaagat aaataaaact acgttttaat ttttacgtta ttaaaaagtt
     7441 gaagtgcgaa ttataatcga gtaaatataa atgatagctt agcttaatta tatattaaag
     7501 ccaactatac ttttattccc gaaaaaccta ctatccaaat ttctaagata ctttagcctc
     7561 tataataaac atattgtaat ataatttatg tattatttag gtttacccta atcagtcata
     7621 ttcaatttaa aaatacatta ttattgctat gatattgtta cttttttgtt tttgattttt
     7681 ttcaatttta ttgaagttag taacaataaa agaatgtata taatctttac tattggtatc
     7741 ttttattatc tcattgtaaa gttttaataa gcgataaggt aaaaagaaca ttacataaat
     7801 acaaatcatt aataaatata ttagtgaaat aaactggttt gtatttatat catgtattat
     7861 agataatatt tgattaatat tttttaaatt tgcaggaaaa atattgtact taaacattct
     7921 ttccattaaa acatacatac ctaccaatgc tatatacaag taaattacaa acctaatctc
     7981 tttttttatg aaattgaata ctctatttaa aatgatagag aaggtaagaa atcttttaaa
     8041 aattctagca atatatataa taaaggaata tcaatcataa ataatccaaa aacaaatcca
     8101 atagccccaa acactctatt ttctttgagt tttgtctgta ttcttaatag gcgtggagac
     8161 acattgtatt taatttcttt tacaccatat atatttgtgg aaatactggt tttagttttt
     8221 gatttttgat ataaaacaat tgtattaaca atataataaa tagttaaata tatcattgaa
     8281 ggtattacaa agaataaacc tatacataac attactgtgt tcaacgtatt cataatatac
     8341 actccttaat tttgtttaca taatgatcgt tatcacttct tatcttaaaa agatagttac
     8401 tatcgactaa ccgataattc aatgctttct ataatctttt catatttaat atagcgttgg
     8461 aaatcacttc aaatgtatta atatcggttc tgttgcaaag taaaaaatat agctaaccac
     8521 taatttatca tgtcagtgtt cgcttaactt gctagcatga tgctaatttc gtggcatggc
     8581 gaaaatccgt agatctgaag agacctgcgg ttctttttat atagagcgta aatacattca
     8641 atacctttta aagtattctt tgctgtattg atactttgat accttgtctt tcttacttta
     8701 atatgacggt gatcttgctc aatgaggtta ttcagatatt tcgatgtaca atgacagtca
     8761 ggtttaagtt taaaagcttt aattacttta gccattgcta ccttcgttga aggtgactga
     8821 tctgtaatta ccttttgagg tttaccaaat tgtttaatga gacgtttgat aaacgcatat
     8881 gctgaatgat tatctcgttg cttacgcaac caaatatcta atgtatgtcc ctctgcatca
     8941 atggcacgat ataaatagct ccattttcct tttattttga tgtacgtctc atcaatacgc
     9001 catttgtaat aagctttttt atgctttttc ttccaaattc gatataaaat tggggcatat
     9061 tcttgaaccc aacggtagac cgttgaatga tgaacgttta caccacgttc ccttaatatt
     9121 tcagatatat cacgataact caatgcatat cttagatagt agccaacggc tacagtgata
     9181 acatccttgt taaattgttt atatctgaaa tagttcatac agaagactcc tttttgttaa
     9241 aattatacta taaattcaac tttgcaacag aaccattttt tgaataccta aaagaacgcg
     9301 gtttacaagg tacggaactc gttatttctg atgcgcacaa aggattagtc tctgccatta
     9361 gaaaatcctt caccaacgta agttggcaaa gatgccaagt tcacttccta agaaatatct
     9421 ttaccaccat tcctaaaaaa aattcaaaat ctttcagaga agctgttaaa ggaattttta
     9481 agttcacaga tattaactta gcgcgtgagg ctaaaaatcg attgattcat gattatatcg
     9541 atcaaccaaa atattcaaaa gcttgcgcat cattggatga tggattcgaa gacgcctttc
     9601 aatataccgt acaaggaaat tcccacaatc gactaaagag taccaatcta attgaacgac
     9661 tgaatcaaga agtacgcaga agagaaaaga ttattcgcat cttccccaat caaacatcag
     9721 ccaatcgctt aattggagcc gttcttatgg acctacatga tgaatggatt tattcttcaa
     9781 gaaaatacat caattttgat aagtagaaat ggtaaaaaca ttgtatagca ttttacacag
     9841 gagtctggac ttgactgagt ttatggaaga agttttaatt gatgataata tggtttttga
     9901 tattgataat ttaaaaggat ttcttaatga taccagttca tttgggttta tagctaaaga
     9961 aaataataaa attataggat ttgcatattg ctatacactt ttaagacctg atggaaaaac
    10021 aatgttttat ttacactcaa taggaatgtt acctaactat caagacaaag gttatggttc
    10081 aaaattatta tcttttatta aggaatattc taaagagatt ggttgttctg aaatgttttt
    10141 aataactgat aaaggtaatc ctagagcttg ccatgtatat gaaaaattag gtggtaaaaa
    10201 tgattataaa gatgaaatag tatatgtata tgattatgaa aaaggtgata aataaatgaa
    10261 tatagttgaa aatgaaatat gtataagaac tttaatagat gatgattttc ctttgatgtt
    10321 aaaatggtta actgatgaaa gagtattaga attttatggt ggtagagata aaaaatatac
    10381 attagaatca ttaaaaaaac attatacaga gccttgggaa gatgaagttt ttagagtaat
    10441 tattgaatat aacaatgttc ctattggata tggacaaata tataaaatgt atgatgagtt
    10501 atatactgat tatcattatc caaaaactga tgagatagtc tatggtatgg atcaatttat
    10561 aggagagcca aattattgga gtaaaggaat tggtacaaga tatattaaat tgatttttga
    10621 atttttgaaa aaagaaagaa atgctaatgc agttatttta gaccctcata aaaataatcc
    10681 aagagcaata agggcatacc aaaaatctgg ttttagaatt attgaagatt tgccagaaca
    10741 tgaattacac gagggcaaaa aagaagattg ttatttaatg gaatatagat atgatgataa
    10801 tgccacaaat gttaaggcaa tgaaatattt aattgagcat tactttgata atttcaaagt
    10861 agatagtatt gaaataatcg gtagtggtta tgatagtgtg gcatatttag ttaataatga
    10921 atacattttt aaaacaaaat ttagtactaa taagaaaaaa ggttatgcaa aagaaaaagc
    10981 aatatataat tttttaaata caaatttaga aactaatgta aaaattccta atattgaata
    11041 ttcgtatatt agtgatgaat tatctatact aggttataaa gaaattaaag gaactttttt
    11101 aacaccagaa atttattcta ctatgtcaga agaagaacaa aatttgttaa aacgagatat
    11161 tgccagtttt ttaagacaaa tgcacggttt agattataca gatattagtg aatgtactat
    11221 tgataataaa caaaatgtat tagaagagta tatattgttg cgtgaaacta tttataatga
    11281 tttaactgat atagaaaaag attatataga aagttttatg gaaagactaa atgcaacaac
    11341 agtttttgag ggtaaaaagt gtttatgcca taatgatttt agttgtaatc atctattgtt
    11401 agatggcaat aatagattaa ctggaataat tgattttgga gattctggaa ttatagatga
    11461 atattgtgat tttatatact tacttgaaga tagtgaagaa gaaataggaa caaattttgg
    11521 agaagatata ttaagaatgt atggaaatat agatattgag aaagcaaaag aatatcaaga
    11581 tatagttgaa gaatattatc ctattgaaac tattgtttat ggaattaaaa atattaaaca
    11641 ggaatttatc gaaaatggta gaaaagaaat ttataaaagg acttataaag attgattata
    11701 taatatatga aaagctatta taaaagacat tagtattaaa tagtttaaaa aaatgaaaaa
    11761 taataaagga agtgagtcaa gtccagactc ctgtgtaaaa tgcggttctg ttgcaaagta
    11821 aaaaatatag ctaatcacta atatatcatg tcagtgttcg tttaacttgc tagcatgatg
    11881 ctaatttcgt ggcatgggga aaatccgtag atctgaagag acctacggtt ctttttatat
    11941 agagcgtaaa tacattcaat accttttaaa gtattctttg ccgtattgat actttgatat
    12001 cttgtctttc ttactttaat atgacggtga tcttgctcaa tgaggttatt cagatatttc
    12061 gatgtacaat gacagtcagg tttaagttta aaagctttaa ttattttagc cattgctgcc
    12121 ttcgttgaag gtgcctgatc tgtaactacc ttttgaggct taccaaattg tttaatgaga
    12181 cgtttgataa acgcatatgc tgaatgatta tctctttgct tacgcaacca aatatctaat
    12241 gtatgtccct ctgtatcaat ggcacgatat aaatagctcc attttccttt tattttgata
    12301 tacgtctcat caatacgcca tttgtaataa gcttttttat gctttttctt ccaaatttga
    12361 tataaaattg gggcatattc ttgaacccaa cggtagatcg ttgaatgatg aacgtttaca
    12421 ccacgttctc ttaatatttc agatatatca cgatagctca atgcatatct tagatagtag
    12481 ccaacggcta cagtgataac atccttgtta aattgtttat atctgaaata gttcatacag
    12541 aagactcctt tttgttaaaa ttatattata aattcaactt tgcaacagaa ccgtatttat
    12601 tatgcattta gaatattaaa attccttcat tacactcttg gcggtttcac ttatcaactt
    12661 atcatttggc ttatcacttt tattgtcttt attcgtaaaa atgactaaaa caataggttc
    12721 agattggccc ttaggataaa caaaagcaac atcatttcta gaagcatatg ttattgcttg
    12781 accactttta tcagcaacct tacagtcttt tgaaacaccg tctttaatta aagtatctcc
    12841 gcttttatta tttaacatta aatcaagtaa gaattttttg ttttctttgc ttaattttcc
    12901 atttgcgata agtttattta aagtcttacc gaaagcagca ggtgttgaag tatctttttt
    12961 gctctttggt gaatagtaat ttaattctat ctcatatcta actggatttg ttactttatc
    13021 tcctagttct tttagacgtt gtttaacttt tttgattcca ccaatttctt ttataatttt
    13081 attgtttgct gtattatcac tatatgccat tgaagcctca ataagttctt ttaaagtgat
    13141 atcttttcct acatattttt ctaaaatagg agaataagca actatatcat ctttgttaat
    13201 atgtattttt ttatttaact tattataagg tacttgttct aacaaaatag cactatttat
    13261 cgcttttgaa gtcgaagcat aggcaaatct cttatctgaa ttaaatttta cttccttacc
    13321 acttttagta tctaaagcat aaacaccaat atgagcatta tatttttttt ctaaatcatt
    13381 taactctttg gcatgtgaac tgtttgaatt acatgcactt aaaactaaag caattgcaat
    13441 taaaaatatt aactttttca aaataaaccc tccaatatta cagttgtaat ttttacaaat
    13501 taataatatt acaattgtaa tattggtgtc aattgtttat tataaataat tgaaagaagg
    13561 tgtcaaaatg gctaaattac taataatgag cgtagtaagc ttttgtttta tatttctatt
    13621 gttagtattt tttaggtata tattaaaacg ctattttaat tatagtttaa attataaagt
    13681 ttggtatcta actgtgcttg ctggattaat tccttttatc ccaattaaat tctcttttat
    13741 aaaatttaat aatgtgaata atcaatcgcc cacagttgaa agtaggtcac acgacttgaa
    13801 ccataacata aataccacca aacctgttca agagttcaca acagatatcc ataagtttaa
    13861 ttgggattca attgataata tctgcacagt tatttggata gttttggtta ttattttaag
    13921 ttttaaattt ttgaaatcct tattatatct taaatattta aagagacagt cactttatct
    13981 aaacgaaaat gaaaaaaata aaatagatac gatacttttc aaccatcaat ataaaaaaaa
    14041 tattgtgatt cgaaaagcag agactattca atctccaata actttttggt atgggaaata
    14101 tattattttg attcctagtt catattttaa aagtgtaatt gacaaaagac taaaatatat
    14161 aatattgcat gaatatgctc atgctaaaaa tagagatact ttacatttaa ttatctttaa
    14221 tatcttctct attattatga gttacaatcc attagtacat attgtaaaaa gaaagataat
    14281 tcatgacaat gaagtagaag ccgatagatt tgtccttaat aatattaaca aaaatgaatt
    14341 taaaacttat gcggaatcta ttatggactc cgtattaaat gttccatttt ttaataaaaa
    14401 tatattaagc cattcattta atggtaaaaa gtcattactc aaaagaagat taattaatat
    14461 aaaagaagcc aatctgaaaa aacagtccaa attaattcta atttttattt gtatttttac
    14521 ttttttgctc atggtaattc aaagccagtt tttgatgggg caatccataa ctgattataa
    14581 ttataaaaag cccttacaca acggttacca aattttagat aaaagtaaaa tttttggttc
    14641 aaatagtgga tctttcgtca tgtacagcat gaagaaagac aaatactata tttataacga
    14701 aaaagaaagt agaaaaaggt attctcctaa ttcaacttat aaaatttatt tagctatgtt
    14761 tggacttgac cgacatgtta taaatgatga aaattcacgt atgtcatggg atcataagca
    14821 ttaccctttt gatgcttgga ataaggaaca aaatttaaat acagcaatgc aaaattcagt
    14881 taattggtac ttcgaacgta ttagtaatca aataccaaag aactatactg cggctcaact
    14941 caagcaatta aattatggta atgaaaactt gggaagttat aaaagctatt ggatggaaga
    15001 tagtttgaaa atatctaatc ttgaacaagt aatagttttt aaaaatatga tggaacaaaa
    15061 taaccatttt agtaaaaaag caaagaatca attatcttct tcattattga ttaagaaaaa
    15121 tgaaaagtat gaactgtatg ggaaaacagg tacaggtata gtaaacggga agtataataa
    15181 tgggtggttt gtaggttacg taattacaaa tcatgataag tattattttg ctacacattt
    15241 atcagatgga aagccgtctg ggaaaaatgc tgaattaatc agtgaaaaaa tattaaaaga
    15301 aatgggtgtt ttaaatggcc aataagcaag ttgaaatatc tatggctgaa tgggatgtta
    15361 tgaatataat atgggataaa aaatcagtat cagctaatga aattgtagtt gaaattcaaa
    15421 aatataaaga agttagcgat aaaacgatta gaacattaat cacaagacta tataaaaaag
    15481 agattataaa acgatacaaa tcagagaata tttattttta ctcatcaaat attaaagaag
    15541 acgatattaa aatgaaaact gctaaaacct ttcttaataa actgtatgga ggggacatga
    15601 aaagtttagt gctgaatttt gcgaaaaatg aagaattaaa taacaaagaa attgaagaat
    15661 tgcgagacat tttaaatgat attagtaaaa agtaattaga gatatgtttc aaacataata
    15721 catatgtaaa ctatgcttga ctcttattaa attagttttg ttaataacat ttaaaatatt
    15781 ttattaaata tgagagtgtc cagaaaataa ccattttctg gacactcttc ttttatgtct
    15841 aaataagtaa gaattacata ggattatgtg ttcaaaaacc caacaaaaaa tctatgttca
    15901 taaaaggcct tgtaattaag ttatggtaca ctgaagatgt atataggagg tttgtatttt
    15961 gaaaataggt tatgcaagag tttcaactgg attacaaaat ttaaatttac aggaggatcg
    16021 attaaataca tatggttgtg aaaagatatt taatgaccat atgagtggtt caaaaagtaa
    16081 aagacctggt ttagataaag caattgaatt tgcgaggtca ggagatacga ttgttgtttg
    16141 gagattagat agattgggac gtaatatgga ggatttaatt acattagtta atgagcttaa
    16201 cgaacgaggt gtaagtttcc atagtttaga agaaaatata acaatggata aatcaagttc
    16261 aactggacaa ttattatttc atttattcgc agcatttgca gaatttgaac gtaatttaat
    16321 tttagagcgt tcttcagctg gccgaattgc agcacgtgct agaggccgat atggaggcag
    16381 accagaaaaa ttaaatcaaa aagatttaaa cttacttaag acactttatg ataatggcac
    16441 gccaattaag acaattgcag aacagtggca tgtttcacgt acaacaattt atcgttacct
    16501 caataaattg gaggacaagg aagatgaaaa acaaggagaa gtatctaact aatttttctg
    16561 aagccaaacg taaaaaagct actcaaaagt ataatattat aaaacctttt atcctaggcg
    16621 aacaatcttt atcaagtatt tctaaaagta aagggattgc gttaagcacc ctttatagat
    16681 ggaataagtc atataaagaa caaggactta aaggactaat ctatgcgaca aaagctgata
    16741 aaggaacacg taaaatagaa ccaaagataa ttgatgaaat tgaacgcctt gcgcttatga
    16801 ataaaagaaa tagtatagcc acaattcata ggaaaaccac taattactgt aaagaaaata
    16861 attttgatat accaagttat aaacaaattt atagtgttat taaagcgatg cctaagtctg
    16921 ttattgattt ctctcatcag ggtgaaaaat actatcaaaa taagtacgat ttaatacaaa
    16981 ttagagaatc ctcgagaccc aatgaaatat ggcaagcaga ccatactttg ctagatatct
    17041 ttatattaga ccaaaaaggt aatatcaata gaccatggct aactattatt atggatgatt
    17101 atagtcgtgc aattgcaggc tatttcttaa gttttgatgc ccccaatgct caaaacacag
    17161 cattaacact acaccaagca atatggaata aaaatgatac caattggcca gtgtgtggta
    17221 tacccgaaaa attctacaca gatcatggaa gtgactttac ttcacatcat atggaacaag
    17281 tcgctattga tttgaaaatt aacttgatgt tttcgaaagt tggtgttcct cgtggtcgtg
    17341 gaaaaataga acgattcttt cagacagtta atcaaacttt cttagaacaa ctgcctggat
    17401 atataaacaa taatgatact cctagtaatc taataaattt tcacaatttt gaagaaaaat
    17461 tacgttactt tttaattgaa gattataatc aaaaagaaca tagtactatt cataccacgc
    17521 ctatcagtcg ttggaatagt aatcactttt tccctaatat gccgagtagc ttagaacaac
    17581 ttgatttatt attgttggaa atacctaaat ctagaaaagt tcattcagat ggcattcatt
    17641 ttcaaggttt tcgatacagt aatactaatc tagcagctta tgtaggtgaa tatgtactga
    17701 ttcgttataa cccaaatgat atggctgaaa tacgtgtgtt ttatagagat gaatttcttt
    17761 gtactgctat atgtccagaa atagctgatt actccataga tataaaagac atacagcacg
    17821 ctcgtagtca gagaagaaaa cacttaaaac aaaatattgc tagtccaagt accacggaat
    17881 taattaagga agaaaaaaat tgtggttatt cacctcaaga aacgactaaa aacgtcaaaa
    17941 aattaaagag gtatcgtaat gactaaaaat caaaatttca ttgaaacgaa agagtataaa
    18001 cgctttgctg aattttgtga tgcttgtatt aaatatcagt atattggtat atgttatggt
    18061 caacctggtg tcggaaaaac tttatcgtct aggtattaca caaattggga tactattgaa
    18121 aaacaagtta accatagagg ttgggaagat ttagctagta aaacgaccga tgacatacta
    18181 tcggtggata aaatatttta tactgcacca gcagaaaaac aatcaggtaa atctatagaa
    18241 aacagacctg tttttcaaga agtattaaat tttttaagaa tgggagatcg tttaattgtt
    18301 gaatctattg atagactagg aagaaattac gaggaaataa ttcaaacagt taattactta
    18361 aaagataaag aagttcagct catgataacg agtttaccta tgatgaatga agtcattgga
    18421 aatccactac tagataaatt tatgaaagat ttaattattc aaattttagc aatgatttca
    18481 gaacaagaaa gaaatgaaag taaacgtcga caagctcaag ggattcaagt cgccaaagaa
    18541 aaaggtatat ataaagggag acctgttctg tattctccca atgctaaaga cccacaaaag
    18601 cgtttagttt attaccgagt tgttgaatta cttgaacagg gtaaatctat aagtactata
    18661 gctaaagaag ttggtattac acgtcaaact atatatagaa taaaaaatag taaataaagt
    18721 aacatagaca ataatctata tagatgttaa tctatttaat atctaggagg tttattcatg
    18781 tcttataaag aactatcaac aatattaaaa attttatcag atccaagtag gttagaaata
    18841 ttagatttac tttcttgtgg tgagctatgc gcttgtgact tattagaaca ctttcaattc
    18901 tcacaaccta cactaagtca tcatatgaag tcattagtag ataatgaatt agttacaaca
    18961 cgaaaagatg gcaataaaca ttggtatcaa cttaatcatg ctattttaga tgatattatc
    19021 caaaacttga acatcattaa tacatctaat caaagatgtg tatgtaaaaa tgtgaaatca
    19081 ggtgactgtt gatgactatt ttagcaattg taatttttct tttaacttta acctttgtga
    19141 tttggcaacc aaaaggttta gatattggta ttacagcttt aattggagcg gttgttgcta
    19201 tcattacagg agtcgtaagt ctttctgatg tattagaagt aacaggtatt gtttggaatg
    19261 caactttaac ttttgtggct gttattctta tttcattaat attagatgaa attggttttt
    19321 ttgaatggtc tgcgatacat atggtcaagg cttcaaacgg taatggctta aaaatgtttg
    19381 tttttattat gttacttggg gcaattgtag cagcattttt cgcaaatgat ggtgcagctt
    19441 taatcttaac gcctattgta ttagcgatgg taaggaatct aggatttaat caaaaagtga
    19501 ttttcccctt tattattgcc agtggtttta ttgctgatac tacatcactt cccttaattg
    19561 taagtaactt agttaatatc gtttctgcag attacttcga tattggattt attgaatatt
    19621 ttagccgaat gatcattcct aatatattct ctctgattgc tagtattctc gttttatggt
    19681 tatatttcag aaaatccata cctaaaacgt tcgatacaga aaatctatca gatcctaaaa
    19741 gtgcaattaa agattctaag ttatttaagc tttcatggat agtattagca gtactactcg
    19801 ttggatatct tgttagcgag tttatccaaa ttcctgtatc aattattgct ggtattattg
    19861 cttttatctt tgtaatatta gctcgtaaat ctaaagcagt tcatacaaaa caagtgatta
    19921 aaggtgcacc atggaatatc gttgtattct ctattggtat gtatcttgtt gtgtttggac
    19981 taaaaaatgt aggtattaca acggtccttg gggatgtttt aacaaacatt tcaaattatg
    20041 ggttatttag cagcatcatg ggtatgggct ttatagctgc tttcttatct tcgattatga
    20101 acaacatgcc aactgtttta atagatgcaa tagcgattgg ccaatccagt gctacaggaa
    20161 tattaaaaga aggcatggtt tatgcgaatg tcataggttc tgatttagga cctaaaatta
    20221 cgccaattgg ttctttagca acattattgt ggctacatgt cttaacacaa aaaggtgtga
    20281 agatttcgtg gggaacatac tttaaaactg gaattatcat cactattcca gtcctatttg
    20341 taacactctt aggtttatac cttacactaa tcatatttta agaaaagggg ctttaattat
    20401 ggataagaaa acaatttatt ttatatgtac aggaaactct tgtcgtagcc aaatggctga
    20461 aggttgggga aaggaaatat tgggtgaagg ttggaatgtc tattctgctg gtattgaaac
    20521 acatggtgtt aatcctaaag caatagaagc tatgaaagaa gtagatattg atatatcaaa
    20581 ccatacgtca gacttgattg ataatgatat tttaaaacaa tcagatttgg tcgtaacgtt
    20641 atgtagtgat gcagacaata attgtcctat tttaccacca aacgttaaaa aagagcattg
    20701 gggttttgat gatccagcag gtaaagaatg gtcagaattc caacgtgtta gagacgagat
    20761 taaattagct atagaaaagt ttaaattgag ataatcataa acacctctta tttagttaat
    20821 aagaggtgtt ttgccattta aagaacaaaa tttgtgccat atacaatatg ccctctcttt
    20881 ttctcattaa cgaacgttta taacgcaatc atgatgagag tattaataca gttaattatt
    20941 tgaaatactt tagtttacat aatgttgaat tataggtagt gaaattgtat ttattataca
    21001 ttgtcatatc gttgtttaat gatagttaat ttaaggataa tagaattaat attatatata
    21061 gatgaacaaa acaagcaaca gagcaaaaaa acacttttag attattttta ctcattctct
    21121 attttattta tttttgctat aataaataaa gaatattaaa tggagttgtt tttatgaaaa
    21181 agaaatttgt ttctagttgt attgctagta caatcttatt cggcacttta ttaggtgtaa
    21241 cttataaagc tgaagctgca acagtacatg tagctggtgg tgtttggagc catggtattg
    21301 gaaaacatta cgtatggtct tattatagtc acaataaaag aaatcatggt tcaacagcag
    21361 tagggaaata ttcatctttt agtggtgttg ctcgacctgg tgttcaatct aaggcatctg
    21421 ctccaaaggc ttggggtgga aacaaaacat tttatagtct tcactaatta catatattaa
    21481 ttaaggagaa tagacagaat taagtaaact taattctgtc tattctcttg aaagaggcaa
    21541 tatgaaaaaa ttcaaattat ttttagattt tagtacttta ttattaattt cagggctatt
    21601 atttttattt ttcttcaaag aaaatgaaga aattatacct gaaagttcca atattttaac
    21661 aatctctaat tgggataaat ctaacagtaa atcaaaagtg ttagatgtca ttgaatcagg
    21721 cgccaaaaat caaaatatac aaataattaa atccgttaaa gattttgata ataaaaaaga
    21781 attttttgtt ttcaactcaa aacgaaataa ttctgacttt atacgtaata aaacatcact
    21841 tttaactcca tcagatttat taaacagaga gataaaagga aagtattata ttattggtga
    21901 acatttcaat gtagaagagc ttacgagtga attaaaaaaa gctggtttaa catctgaagt
    21961 tgaatacata aatagaaaca tattattttt tgaattagtc atagataatg atttattagt
    22021 gcctttcata ttcttaggcg tattatatct tttgtacttc ttatatgaca gaggatataa
    22081 tttgaaattt tatgctattc aaaagctaca tggcttttca actacacgca ttatttttca
    22141 taatattcat ataaaaatca tttattggct agtacttacc actattttct ttattgctaa
    22201 tatattaatc attcatatag ccaatttaga attggatttc ttaatgttta ttcgtagatt
    22261 tatcgtgttg ctttttgttt ttgcttgtat tactacattg ttgtggctga tttcgtatag
    22321 tcttcttttg aagttaagta ttccattaac cttaaaaggg aaaaaaggat ataagttttc
    22381 aatatttatg ggtaccttca ccaaatgtat catggtgcta atactatctt ttttactggc
    22441 acaaaattta aatgcttata cgaagttaaa gaatatatat gactctgaaa aaatctggca
    22501 aaagttagat aattactata cattagagat ttctcctaat attagaaatt cagaagaaaa
    22561 acaaatttta gaaactaata tatacaattt aattaagaaa agcgaacaac ttggtggatt
    22621 gcttttaaag aataataata tagccaatcc cgataaaaac aattacattc ctgaaaatgg
    22681 caatgtcttt tttatcaata acaattttct gaatttctat aaaaatataa atcatgattt
    22741 taaaatgatt gacaatcatt cggataaaat aaacgtgttt attcctccaa ggttacaata
    22801 tcaaaaatct gaaattcaaa aaaatcacca aggatggatt gactttcaaa agcaacaaaa
    22861 caaaaaagta gatgtgcaag tactgtcaaa aaacgtatct gttttttctt ttgatcgcac
    22921 aactaatttg aaatttggat atctagattc tccaatagta atgttgttga cacctgacga
    22981 tttaacagga gatttttatt tagctgctgt ttctcaaggt ggatatctat ttaaagattt
    23041 agatacactt aaacagttgc ttaaagataa tcacctagaa gaagaaatta gcggtataac
    23101 taattacaag gattctgtgt taaatgaatt aaatgaaacg aaaacaaaaa tgataataac
    23161 aatagttact attattatta acgttttcat tcttttgata gctactgtat ttgaaacaat
    23221 tcaatatttt agctggaata aaaagcaact attattaaga aaaattcatg gttattcatt
    23281 attcagcagt aatgtacgtt atttaacaat ttctatttta ctttctatta tgttagctta
    23341 cactacgcat attttatttg gttcaaagat attactattc ataataatgt ctattgctat
    23401 tattcaacat ttacttcaaa ttgcttatat taaatatctt gaaaaatact ttaaagattt
    23461 aatgagggag atttaaacaa tgaaaagaac tttaattatt gtaacaattg tactattaat
    23521 catcatactt agtctgttat tggttagaaa tgagcattta gatcgtttta acccactgtt
    23581 aaaagaaaaa gtatcttatg ccaaagttcc aaaagatacc caggactata gaaatataac
    23641 tgtatactct aaaaatggag aaaaaaagag ttataaattg gattttttag gttatgatcc
    23701 tacaaaagaa tatgtgaaag taaatcataa agggaaatat gtgcgttcga tagaatacat
    23761 tacaaaagat attcctagct ttttaaaatg aggtgaccga tagtgataaa acttgaaaat
    23821 gtttttgtaa aaaaaggtaa taaaaacatt ttagacggat gtaactttaa ttttgaaaaa
    23881 ggaaaatcat atgctttagt tggagaaagt ggcgctggaa aatctacttt acttaacata
    23941 atcgctgggt tcgaagatgt atcacaagga agcatatata ttgaagataa gttactaaaa
    24001 aagaaagtcg atttttatag atatacgtta gggtatttgt ttcaaaattt tgctttactt
    24061 gaaaatcaaa caatcagtca aaatttagat ttagccctaa agttcaaaaa gaataaaaaa
    24121 gataatatga acttaaagaa agaagtatta aaaaaggtcg gcctagattt agatatcaag
    24181 agaattgtta gttctctaag cggtggtgaa caacaaagag tagcattggc aagattaata
    24241 ttaaaagatc cgaaaatcat tttagctgat gaacctactg gatcactaga tacgaaaaat
    24301 ggaaaaatag ttattgattt attattgaag ctacttgatg aaaataaaac tatgattgtc
    24361 gtaacgcatg atttagagct tgcgaaacga tttgatgtca tagtcaatat ttctgagctt
    24421 agaagttaag aaatattgat aggtatagcc atacatagag aaaaaacaat atgaaatatg
    24481 attagtcatt acttttgagt tttttaattt aaggactgga ttttccagtc cttttttgtg
    24541 atgacaaaaa acaagcctcg cagagcacac gtttttaatg acttatttgg tttttaataa
    24601 gtctagtatg ttaaaacttt tctgtgttta ggtgttataa tcatatgcag tggaagttga
    24661 tttattatgt cttattcaat tattcgagtt gttaaagtga aatcaaaaac aaatacaaga
    24721 ggtattcaaa gagaaaataa aaattatgaa aatatagata ttgatttaag taagtcatat
    24781 ttaaactatg atttagtcaa tgatactaag tttgatttta ataaaaaaat tgatgagaaa
    24841 atcgaacaaa attataaagg gaaacgcaaa attagaacag atgccattaa acatattgat
    24901 ggattaatta catcagataa tgtgttttta atcaattatc tgaagaagag acaaaatagt
    24961 tttttaagca tgctaaagcg ttcttggaag aagaatacgg taaagaaaat cttttatatg
    25021 cgacagtaca tatggatgag ataacaccac atatgcatta tggcgtaatt cctattacta
    25081 aagatggacg tttaagtgcg aaagaagttg taggtaataa aaaagcatta accgaattcc
    25141 aagatagatt caatacgtat attaataagc aaggctatga tttaaaacga ggaatttcta
    25201 gacaacttac aaaagaaaaa catgatcaag ttagcggcta taaacaaaaa acagaatatc
    25261 ataaacaaat gtatatgcgc gagaagcaaa tagaggatca tttaaagtaa gaaaatgata
    25321 aattgataca aaactaccaa aaatcattag atacgcttaa aaagcttctg agtgtcatgt
    25381 atgaaattaa aactaaaaat gtaggtggat ggtttcataa agagaagcaa gaaacaggca
    25441 atattgtaat tactaaaact tattttgaaa aatacactaa acaaattaaa gcagcacaga
    25501 tgatattaga tgattatgaa tggattaaaa gtgggaagtc attaaaaaaa tcagagaaac
    25561 aaaatgaaag tttagttaat gaattgacta gtgtccatat ggaaaatgaa aagctggttg
    25621 aagaatttaa tgatttagca caacgttata attatttgtt gtcagagaat gaaaagaaag
    25681 ataaagaact aaattatacg cttaagttat tcaatcaagt ttttaaaatc attaaaagta
    25741 tgatgaaaga agagcgttat catacgctaa taaatcatat tgataatcat ttagacaatt
    25801 ctaaaatacg tgaagtaatg acgatagata acaatgatga acagttcttt aagaagaaat
    25861 atcaagcaca agaatgagaa atcattttta aagaagatag agaagatggt tatacattat
    25921 aaaaatagat atttaaatgc atttgtttga ggttaattat tttttaggat gaaaaatagg
    25981 tagcccccct ctaacttttt aatatatttt tataaatctt tttaaaaatc ttttaggggc
    26041 ttgttcagac ctagagcaac aagggatttc aatgcctaaa ggagtgtttt tgccacataa
    26101 aaggagtgtt ttaaaaagtt gtactccttt tatggtttga cattgataat aaagtagttt
    26161 attgtgaata aaagttttca aatgggagtg tatattcaaa cgatactcct ttaggttcgt
    26221 aataaagggg gctgtatcat gacaggagag acagttgtat ataaaaatga aatgaattta
    26281 gttccattaa ggcgatttac agctactgaa attaatttat tttttgcgat gtgtaataaa
    26341 ttaaaagagc aagatactaa tacattacgt ttgtcttttg atgaattaaa aaaattaagt
    26401 aattatagtc cagaaacacg taatattaat agatttgcta atgatttaga taatgtgtat
    26461 aaaaagatgt tgaatttaac cattagatat gaagatgatg atgtaataga aagattcgtt
    26521 ttattcaatc attatagaat ccataagcga gaacaatatc tagaaatatc aacttcttca
    26581 aatttaaaac acatattgaa ttcaattact aataatttta caaaatttga attaaaagaa
    26641 atgactaggc ttaaatctac atattctaaa aatatgttta gattacttaa acaatacaaa
    26701 catacaggct atttaaaaat tcacatcgat gattttaaaa atcgtttaga tatacctaaa
    26761 tcttatcgta tgactgatat taacaaaaat gtttttaaac ctattattat tgaattaggt
    26821 tctatattta ataatcttac tatcaataaa atcaaagcga aaaaagggcg taaaattgaa
    26881 tggatagagt tcacatttga cgctgagaaa cgcattcata acaaacgaca acctcaaatg
    26941 tccaagatag ataaatcaag acaatatgtg aggcgtgaaa agacgcctaa atggttagaa
    27001 gaacggtcat atgaaaagca acctcaaaaa gattacgacc cacaattaga gaaagaacga
    27061 gaggattttt taaaacaact tgaactgaat tgggaataac gcaacttttc gttgcgagtt
    27121 ggttaactaa aagtatcgtg acttttcaat tattttaatt atagtttgag ttaaggagtg
    27181 attttatgaa attagctgaa gctataaaag aacagagaga attaaaaaga tggtctcaag
    27241 aggaattagc caatatatta aaggtttcca gacaaagtgt ttctaaatgg gaaagtgcca
    27301 aaaactatcc ttccttagat attttgattg ctatgagcga tttatttgga atctctttag
    27361 agcatttaat taaaggagat gcacgtttta aaaaagttat tttagaggga aattatagag
    27421 agagtaacag ggcaccttcc atagttgatt ttctttatga tttttggtgg cttttctttc
    27481 ctgttgccgg atttttagtt tgggccattc attcgttcat gggttgattt taaaatcaaa
    27541 atttaatgca catcaggcaa tatgaaaaag gaaagtattt ttacgacacc ttgaaatgta
    27601 ttgataagaa tagaagagtt tacaaaaggc aatatgaaat atatactaaa agtaacaaga
    27661 atttcgtttg taaacgcacc aaaccccgaa ctattcgccg tagttcgggg ttttttggtg
    27721 aattggcttt aatcgtctat attatttttt atcacgttta tggagccaat aaccaaataa
    27781 cgtaacgaga caaccactga ttgccgttgt catgatgtga acaagaattt cattcataaa
    27841 tcgcacctcc tctctacgcc gaattgacgt ctgagagata gacgaccttc acattataac
    27901 aaatctcttc ttccatgaaa taacatgaat attaataaat gttgttatat attaaagata
    27961 aataaatata agggtgggat tgataatgtt tggcgatcaa agacaagaag ctacaaaata
    28021 tgtcattaaa gaaggttatc aagatattta tttcctcaac aaaaacgggg aatggtatta
    28081 tttcgaagta agaagtgcct ggcgtggcaa acatattatt agagttaaag atggtttgtt
    28141 aggttggaga aaagaaatag taactgaata aagatacaaa atacttgcca atgcaaaaga
    28201 atgaaaacgc gtcaaatcaa cgatgtataa aagatgcata aaagataatg aaagtaaaaa
    28261 gccataaatg ccgtcatata ggcatttatg gctttttgtt tggttaacat aatcgatgat
    28321 taccagaagt tctcactata taaaagacac taaaatttta taacttttag tgcctaatca
    28381 attattttag ctaccaaaca aacgactcca aaaccccttt ttaggttccg tttcttcact
    28441 cttttcttct atatcactat cattgtcatt tagattagct ggaacgtctt ctttttttgc
    28501 ttcttcacct tgtgtacttt cgtcgctttg acttccagat atatccttat attgaatctc
    28561 tgtttcttta gtttcttcct gatctctgtt aatatttaca ggattagtag tatatgtttt
    28621 ttcttgtgca tcaacgtttt gtctagtgtt agtagatgta tcaaagggat aattaaggtg
    28681 tttttctttt tctaattgat tttctaattt ttgaatcttt ttattactct ctaatgccag
    28741 aacttgctga ttttcaagca attttgatct ttcttgcaac tcttttctgt aaaattcaat
    28801 tgttgtttca tgacgacttt cttgtttttc aatttgatta tttaaagtat caatctgatt
    28861 tttaaggatt tctactattt gagcatcgct tttcgattca aaattaatat tatccgaccc
    28921 ttttttttgt ttgtcttcag tagtactttc aaaaccatat ttctttttat tttcatttac
    28981 tctttgaatg attttttcta tatcggtatc ttctttaata aacgaagtgt tttcctgttt
    29041 tattgtctct atattcaatc gcttaatatt attaaaaatc gtttgcttac taacccctaa
    29101 ttcttcactc aactttttca cacttttcat atcatcaacc ctttataaaa tgtttataaa
    29161 cccttgataa aatattataa gcttataatg cttaataata aagtgattaa taaataaaaa
    29221 taaacatcca tcaacctttt tatcaagggt ttatgaaagg tttatgatat ttatcaaggg
    29281 tttataaacc cttgataaag ctatattttc ccttttataa gttt
//
