LOCUS       NZ_CP036449            19305 bp    DNA     circular CON 26-NOV-2023
DEFINITION  Klebsiella pneumoniae strain KPNIH45 plasmid pKPC-610e, complete
            sequence.
ACCESSION   NZ_CP036449
VERSION     NZ_CP036449.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN03455990
            Assembly: GCF_002918585.2
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 19305)
  AUTHORS   Weingarten,R.A., Johnson,R.C., Conlan,S., Ramsburg,A.M.,
            Dekker,J.P., Lau,A.F., Khil,P., Odom,R.T., Deming,C., Park,M.,
            Thomas,P.J., Henderson,D.K., Palmore,T.N., Segre,J.A. and Frank,K.M.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
            Bacterial Plasmids Conferring Carbapenem Resistance
  JOURNAL   mBio 9 (1), e02011-17 (2018)
   PUBMED   29437920
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19305)
  AUTHORS   Conlan,S., Thomas,P.J., Mullikin,J., Palmore,T.N., Frank,K.M. and
            Segre,J.A.
  TITLE     Whole genome sequencing of Klebsiella pneumoniae ABFPW
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 19305)
  AUTHORS   Segre,J.A. and Mullikin,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-FEB-2019) NIH Intramural Sequencing Center, 5625
            Fishers Lane, Rockville, MD 20852, USA
REFERENCE   4  (bases 1 to 19305)
  AUTHORS   Segre,J.A. and Mullikin,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JAN-2018) NISC, NIH, 5625 Fishers Lane, Rockville, MD
            20852, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: canu v. 1.6
            Genome Coverage                   :: 165x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/26/2023 03:02:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,600
            CDSs (total)                      :: 5,474
            Genes (coding)                    :: 5,341
            CDSs (with protein)               :: 5,341
            Genes (RNA)                       :: 126
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 90
            ncRNAs                            :: 11
            Pseudo Genes (total)              :: 133
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 133
            Pseudo Genes (frameshifted)       :: 50 of 133
            Pseudo Genes (incomplete)         :: 80 of 133
            Pseudo Genes (internal stop)      :: 17 of 133
            Pseudo Genes (multiple problems)  :: 11 of 133
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036449.1.
            Bacteria and source DNA available from Karen Frank, Department of
            Laboratory Medicine, National Institutes of Health Clinical Center.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..19305
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="KPNIH45"
                     /db_xref="taxon:573"
                     /plasmid="pKPC-610e"
                     /geo_loc_name="USA"
                     /lat_lon="38.984652 N 77.094709 W"
                     /collection_date="2014"
     gene            complement(join(18817..19305,1..831))
                     /locus_tag="C3377_RS01395"
                     /old_locus_tag="C3377_001400"
     CDS             complement(join(18817..19305,1..831))
                     /locus_tag="C3377_RS01395"
                     /old_locus_tag="C3377_001400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152397.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1182-like element ISKpn6 family transposase"
                     /protein_id="WP_004152397.1"
                     /translation="MAASYLPYRPDQSYLLPPSLGEWLPEGHLAYFISETVDTLDLSAF
                     HARYAGGGPGNQPFHPAMMVKVLIYGYASGVFSSRKLARKLYEDVALRVLAAGNFPAHR
                     TLSDFRALHLTELENLFVQVVQLARECGLVKLGTIAVDGTKVKANASRHKAMSYKRMKP
                     AEDELHCEIKALLDRAKATDDQERNEPELDIPAEISRREKRLEAIQAAKARLEARQREA
                     DQARGRSEDDGRRPRHPDGSDKGGGSYKREFGVPDDRDQESFTDPDSRIMKHAGGGSEQ
                     SYNGYTAVDAEHQIIVAAELTNCAADSQALLGMLAAVQANTGEMPAQTLADAGFRSEAV
                     LAKVADHHGDVIVALGREGREDAKVNAKTHPHTAAIAAKLKTEQGDAAYRRRKSIVEAP
                     NGWIKAVMGLRQFSMRGLDKVQAEWKLVCMALNLRRMAYL"
                     /name="IS1182-like element ISKpn6 family transposase"
     gene            complement(1261..1638)
                     /locus_tag="C3377_RS01400"
                     /old_locus_tag="C3377_001405"
     CDS             complement(1261..1638)
                     /locus_tag="C3377_RS01400"
                     /old_locus_tag="C3377_001405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            1707..1886
                     /locus_tag="C3377_RS01405"
                     /old_locus_tag="C3377_001410"
     CDS             1707..1886
                     /locus_tag="C3377_RS01405"
                     /old_locus_tag="C3377_001410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(1914..2444)
                     /locus_tag="C3377_RS01410"
                     /old_locus_tag="C3377_001415"
     CDS             complement(1914..2444)
                     /locus_tag="C3377_RS01410"
                     /old_locus_tag="C3377_001415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(2451..3182)
                     /locus_tag="C3377_RS01415"
                     /old_locus_tag="C3377_001420"
     CDS             complement(2451..3182)
                     /locus_tag="C3377_RS01415"
                     /old_locus_tag="C3377_001420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     gene            complement(3182..5146)
                     /locus_tag="C3377_RS01420"
                     /old_locus_tag="C3377_001425"
     CDS             complement(3182..5146)
                     /locus_tag="C3377_RS01420"
                     /old_locus_tag="C3377_001425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_004178196.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(6627..6776)
                     /locus_tag="C3377_RS01430"
                     /old_locus_tag="C3377_001435"
     CDS             complement(6627..6776)
                     /locus_tag="C3377_RS01430"
                     /old_locus_tag="C3377_001435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(6861..7118)
                     /locus_tag="C3377_RS01435"
                     /old_locus_tag="C3377_001440"
     CDS             complement(6861..7118)
                     /locus_tag="C3377_RS01435"
                     /old_locus_tag="C3377_001440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            complement(7128..8813)
                     /locus_tag="C3377_RS01440"
                     /old_locus_tag="C3377_001445"
     CDS             complement(7128..8813)
                     /locus_tag="C3377_RS01440"
                     /old_locus_tag="C3377_001445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_004178188.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            9216..9635
                     /locus_tag="C3377_RS01450"
                     /old_locus_tag="C3377_001455"
     CDS             9216..9635
                     /locus_tag="C3377_RS01450"
                     /old_locus_tag="C3377_001455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="WP_001254601.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="Exc2 family lipoprotein"
     gene            9941..10204
                     /locus_tag="C3377_RS01455"
                     /old_locus_tag="C3377_001460"
     CDS             9941..10204
                     /locus_tag="C3377_RS01455"
                     /old_locus_tag="C3377_001460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     gene            10194..10529
                     /locus_tag="C3377_RS01460"
                     /old_locus_tag="C3377_001465"
     CDS             10194..10529
                     /locus_tag="C3377_RS01460"
                     /old_locus_tag="C3377_001465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_103857364.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIGVLSGNP
                     RKFRHSV"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(10537..12252)
                     /gene="tnpR"
                     /locus_tag="C3377_RS01465"
                     /old_locus_tag="C3377_001470"
     CDS             complement(10537..12252)
                     /gene="tnpR"
                     /locus_tag="C3377_RS01465"
                     /old_locus_tag="C3377_001470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn4401 family resolvase TnpR"
                     /protein_id="WP_004152391.1"
                     /translation="MKTGQTTASSSTPVGFPDADSLAALRGWYAGLSSRAAVEHYLAAR
                     KAAGQSARGMLGHIRRQLIVFANSRHRPDLADVFQHAPEERQGRAGAVERAIRLLPTLP
                     APKPQISDSIDQWLSPRTVRALQAYGIHTLSALTVRIPRRRGWWKAIEGLGMTGARQVE
                     AFFAAHPQLTERARALIPIIQPSGIVPWEQLRLPNEVDGSQGNFRAPRNACTLNATNDY
                     EAVQAWLALHETVATQRAYRKEAARLILWAIVERGRALSSLTTDDAIAYRAFVRHPTPR
                     ERWVGPPRPRDSVEWRPFSGGLSARSAAYALTVLSALFRWLIEQRYVLANPFAGVKVRG
                     HALRPALDTARGFTEGEWLLLRAIADGLEWSYGWSEPAAQRLRFMLDFGYATGLRASEL
                     VGAVLGNVRLDEHGDHWLHLVGKGGKPGKVALPPLAYTALDQYLAQRQLPVSRERWNPK
                     TPLVGSLGEDGNAGITGPHLWCVLRRFFTQAAEAIEADHPVAAEKLRRATPHWMRHSHA
                     SHALARGAQLTAVRDNLRHASIATTSMYLHGDELERARQMRQAFGARHVKRGVD"
                     /name="tnpR"
     gene            12362..15391
                     /gene="tnpA"
                     /locus_tag="C3377_RS01470"
                     /old_locus_tag="C3377_001475"
     CDS             12362..15391
                     /gene="tnpA"
                     /locus_tag="C3377_RS01470"
                     /old_locus_tag="C3377_001475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152392.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn4401 family transposase"
                     /protein_id="WP_004152392.1"
                     /translation="MSKKNKLLSVLSDAEQEALYGLPEFDDAQQLEYLAVTETELALAN
                     SRPSLHAKVYCLLQIGYFKAKHAFFSFDWDEVEDDCAFVLSRYFHGEVFEPKAITKHER
                     YTQREQIAKLFGYWPWSAAFLPQLEQQAARTVRRDVTPGFVAAELIVWLNEHKIIRPGY
                     TTLQELVSETLSAERRRLGNLLEQALDESAKAALSQLLVRDDTLSQLAALKQDAKNFGW
                     RQMVREREKRATLEPLHAIAKTLLPKLDVSQQNLLYYASLANFYTVHDLRNLKADQTQL
                     YLLCYAWVRYRQLSDNLVDAMAYHMKQLEDESSAGAKQSFADEQVRRQQETPRVGRLLS
                     LYVDDSVADPTPFGEVRQRAYKIMPRDTLQTTAQRMSVKPASKLALQWQAVDGLADRMR
                     RHLRPLYVALDLSGSNPDSPWLAALAWAKGVFAKQQRLSQRPLDEWPAATLPKRLRPYL
                     LTFDADGKPTGLHADRYEFWLYRQIRKRLQSGELYLDDSLQHRHFSDELVEMDRKIDVL
                     AKMEIPFLQQPVHAQLDALTAELRTQWLAFNRELKQGKLTHLEYNKDTQKLTWRKPKSE
                     NEKAREKAFYEKLPFCDVADVFRFVNDECKFLSAFTPMQPRYAKKVADADSLMAVIIAQ
                     AMNHGNHVMARTSDIPYHVLDSGYQQYLRQATLHAANDCISNAIATLPIFPYYSFDLET
                     LYGAVDGQKFSVERPTVKARYSRKYFGRGKGVVAYTLLCNHIPLNGYLIGAHDYEAHHV
                     FDIWYRNTSDIMPTAITGDMHSVNKANFAILHWFGRRFEPRFTDLNAQLKELYCADDPA
                     QYQACLIRPVGKIDCDLIHREKPNIDRIVATLGLKEMTQGTLIRKLCTYTTTNPTRRAI
                     FEFDKLIRSIYTLRYLRDPQLERNVHRSQNRLESYHQLRSAIAQVGGKKELTGRTDIEI
                     EISNQCARLIANTIIFYNSAILSRLVTKYEAAGNSKALALITKISPAAWRHILLNGHYT
                     FQSSGKTIDLDAIVAGLELE"
                     /name="tnpA"
     gene            15498..16523
                     /gene="istA"
                     /locus_tag="C3377_RS01475"
                     /old_locus_tag="C3377_001480"
     CDS             15498..16523
                     /gene="istA"
                     /locus_tag="C3377_RS01475"
                     /old_locus_tag="C3377_001480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032490293.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS21 family transposase"
                     /protein_id="WP_004199214.1"
                     /translation="MLTQEQTVEIRVLARQGHSIRHIARTLGVSRNTVRRYLRDPSVAR
                     YQPREPRPTKLGPFESYLRQRVEQAHPIWLPATVLNREIRAQGYGGGLSLLRAFLATLK
                     PARREAGPAVRFETEPGRQLQADFVVLRRARSPMSAFVATLGYSRMTFVTFVPDESFES
                     VRDSLLLAFDYLGGVPREVLFDNMKTVVLERDAYGDGKHRFHPGLLQLADDLGFRIRLC
                     RPYRAQTKGKVERFNRYFRESFYNPLLTRMKGTGLLLDCAAANRRVRDWLADEANVRVH
                     ATLNERPIDRWRQEREHLQPLPSRVRRDEAPLLDNSLRPVPLESLQHPLSVYDAIGEAC
                     R"
                     /name="istA"
     gene            16520..17299
                     /gene="istB"
                     /locus_tag="C3377_RS01480"
                     /old_locus_tag="C3377_001485"
     CDS             16520..17299
                     /gene="istB"
                     /locus_tag="C3377_RS01480"
                     /old_locus_tag="C3377_001485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS21-like element ISKpn7 family helper ATPase
                     IstB"
                     /protein_id="WP_004152394.1"
                     /translation="MNLQHERIDALCQQLKLERVATHYPVLAQQAVREDFSFTDFLEHL
                     LRHEAGCRQQRSRELLTRMACFPGIKTLEDYDFSFNPGVPKALVQELGSLAFVERAENV
                     VLIGPSGIGKTHLAIALGYKAAQAGVKTRFITAADLMLQLSTAQRQGRLKEYFNRAILG
                     PRLLVIDEIGYLPFGREEANLFFQVVAKRYEKGAMILTSNLPFSQWADAFAGDTTLTAA
                     MLDRLLHHAHILTLSGESYRLKDKRKAGVVRKNSKPE"
                     /name="istB"
     gene            17686..18567
                     /locus_tag="C3377_RS01490"
                     /old_locus_tag="C3377_001495"
     CDS             17686..18567
                     /locus_tag="C3377_RS01490"
                     /old_locus_tag="C3377_001495"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015256839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbapenem-hydrolyzing class A beta-lactamase
                     KPC-3"
                     /protein_id="WP_004152396.1"
                     /translation="MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIG
                     VYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPW
                     SPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDR
                     WELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRA
                     AVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAA
                     RLALEGLGVNGQ"
                     /name="carbapenem-hydrolyzing class A beta-lactamase KPC-3"
     ARG             17687..18564
                     /name="blaKPC-3"
                     /gene="blaKPC-3"
                     /gene_name="carbapenem-hydrolyzing class A beta-lactamase
                     KPC-3"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     BGC             2128..13813
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          5946..6524
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(2455..3182)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.35e-150"
ORIGIN
        1 accaccggcg tgtttcatga tccggctgtc cggatcggtg aagctttcct gatcacggtc
       61 atccggcaca ccaaactcgc gtttgtacga gccaccgccc ttgtccgagc catccggatg
      121 gcgaggccgg cggccatcgt cttcgctgcg cccccgggcc tggtccgctt cacgctggcg
      181 cgcttccagg cgcgcctttg ccgcctggat cgcctccagg cgcttctcgc ggcgagaaat
      241 ctcggcagga atgtccagct ccggctcgtt acgctcctgg tcgtcggtag ccttggcgcg
      301 atcaagcagc gccttgatct cgcaatgcaa ttcgtcctcg gccggcttca tgcgcttata
      361 gctcatcgcc ttgtggcggc tggcgttggc ttttaccttg gtgccgtcga ccgcgatcgt
      421 gccaagcttc accagcccac attcgcgcgc cagttgcacc acctgaacga acaaattctc
      481 aagctcggtc aggtgtaggg cacggaagtc actcagcgtg cggtgggccg ggaagtttcc
      541 agcggccagc acacgcaacg cgacatcctc gtacagcttc ctggctagtt tgcgcgaaga
      601 gaagacgccg ctcgcgtaac catagatcag cactttgacc atcatcgccg gatgaaacgg
      661 ctgattgccc ggaccaccgc cggcataccg ggcgtggaat gcgctcaagt ccagcgtatc
      721 gacagtctcg ctgatgaagt aggcaagatg cccttcaggt agccactctc ccagagaagg
      781 gggcagcaga taggattggt cgggtcggta aggaaggtaa ctggcagcca tccccgtatc
      841 gtcctcgatc ttccgccgat ttggcttctg ccgcgcaggc tcctaggcca ccgtagctaa
      901 acatacgaga aaaaccgctt cttgagcgct ctctgagacc accttgccga caacgcagaa
      961 acggttgcgg aaaaatcggc gtttccggcg tacgccaccc gacctggacg aactattgcg
     1021 gacctggaac tggagtagcg gaattccccg gggtttcagc gtcgcgccac agcgcctcag
     1081 atagatgcgg tagcctttgg cgggtcgtca tgccgcggac caccccccca aaaaattcca
     1141 caatgcggaa tggcggaatt ttctggggtt cccgcttacc cccccatatt gttctctaat
     1201 aaccggtgac ggggacgcaa ttcattgcgt ggccgtcgcc ggttggacaa gcacagcgcg
     1261 tcagcgtttt ccccacggcc accaccggcg cggtgttccg gccggggtct ctgctgtctc
     1321 cggtttgtgt tccagcagtc tcatggactg catttcctgc cgtagcccgg ccacctcctc
     1381 cctgagtgct tttatctccg cgatcaacgc gtcggaggcc attttttcag tctcacccga
     1441 cagtctcaac tcgtcccgct cgtgagtctc atcctgtctt aactcaccgt acacccggat
     1501 aagctcgctg gtatccacca cccggccgcc atcagcttcc gtacggtatg atacgcggcc
     1561 tttcgccata tcccgataca gggaacttcg ggctttaccc gtcagttccg tcgcctgtct
     1621 caccgtcacc cacgccattg tctcaccccg ctatttttga gacagtatac ctgacaggcg
     1681 cacaccatgc ccggaaggaa agaatcatga caaaacagga aaaaacagcc ctcaatatgg
     1741 ctaaatttat taaggagcag tcgctgctat tgctcgataa actgaatgag ctggatatgg
     1801 ataccccggc cgacatgtgc gagcggctac acgaggatgc ggaaacactc tggcaggtga
     1861 tgcgggataa gctcggggag gaataacagc accggcatgg ccggtgctgg catttatttt
     1921 ttgccgaacg gccaccaccg gcgggcaggt ttgtcctccg gcagttcagg taccggcacg
     1981 ttaaaatagc ggctgttata ttcccgcatc agctccgctt tcagcttctc gttcaccgcg
     2041 ctttccccgt gccgctcact caccacgtca atcatcgcgt taatctgctc cggtgagcac
     2101 ttcccggcat caaccacctg cacaccgttc tcgatggcga accgctccac cttgcgatag
     2161 aggtaatcac acagcttcat tcctgtgggt ttgttccgtt cccattgcgg atttttacca
     2221 gtgaaaaagt acgtggcttt ttcgtcgctg ttgagccgct cgtcatacat cccgatggat
     2281 ttcatcatcg ccagatgctg ggcccggtcg acaaaacaga aaacatacgc cccggtctgc
     2341 caggcgagca ccaccatatc ttccagatgc tcgctggtcg gcatgatgca gcgctcgccg
     2401 ttccggtcct ccgcgtcttc aataaatacc atgtacagcg ccataatccc tcactccgtt
     2461 gtcataaatt taaagcacgc aaacaaccgt tcacgatcca gctctgccgt tttgcgggcc
     2521 tcgccggtct gtgggttcac gatttcatcc accgacagga ttgcccgctg caccctgacc
     2581 tgcgtcgccc ggtccgggca gatgtaccag atttcatcga tgccgttagc tttgcggttg
     2641 aacagatacc cggacaccac ttcctgatac cggcgacggc tcttgacggt gcgctccacc
     2701 tcaaacgcca ccgttttacc gtccagctcc gccagggcgt ccggcacttt catgccttta
     2761 agactcagac ggtgcagaat gcgccagccg gtggcccctc tggcttccat atcaaggcgc
     2821 agggattgca cggccagccg gtgcggcaga tgtgctgccg acacccttga cggctgaaac
     2881 ggaataacat ccgccagcgg ttcgtcctcg tcgaacgaga acgccacgcc atgcggcgtc
     2941 agcccccaca cgctgacctg acggccgtcc accggatatt tggtccggac cagcagccct
     3001 ttcgccacca ggctgtcgag gaagcggtag accggctgca ccgccgcaat ccccagccgc
     3061 cgcgcaacca gctccgccgt ggaacacagc tcttcccgca accagcgcag ggtcagccgg
     3121 gttttctccg cgttccgcgc ctgtcgtttc gcgtggctga cgttgtacag ctccagcgcc
     3181 atcagtaaat ccccgcaaaa tcatcatccg ctttcggccc gccgccgtcg gccgggggcc
     3241 ggaactccgc caggggatcg gttttcgcca gcaccgggaa acgctgcaac gggatttccc
     3301 ggcgctcaac ccgcagcgga ctgctgaacg ccatccgggc cacacccagc ccggtcatga
     3361 ccgcgaaccc gtccggcagg tgttgcaggg tgttcacgtc aaacagcggc cgcgcctcct
     3421 tctggatgaa gctgtccccg ctgatatgct ccacgttccc cgcctcccgg ctggcacggc
     3481 ggcgctccac gtccaccctg atttccccgg tctgccccgc cgcccactgc gcggactcca
     3541 ggctggccgc ccggtaaaac cagcggatcg gcgtgttatc cagtaccgtg gttttcacaa
     3601 attcagcggg cagatcctgc ccgcactgcc cgaaatcgcc cagcgactgg tgcgcgagca
     3661 acagattgca gtcccggctg cgcagcgtcc ccagtgcgtt cagtacatac ttcgacagca
     3721 gatatttaat ttcatcgagc atcacgctga cgtgtggcca ctcccggaac tcgtcccgcg
     3781 caatgatgat ttgcgcgcag cgggcaaaca gcattttttg cacacggatc accgcctcgt
     3841 cgtccatcga gccgataacg tacaggcagc cgccgccgtt gataatcccc gccacatcga
     3901 tgccactgtc cgtctgcagg acgctcaggt cagcgacgtt ttccagccta gtgatcaacc
     3961 ccttcacgtc ctttttcagg gcctccggca gcgcgtacgc cgccgccagc acctgctgaa
     4021 tgtttgcccc ctgcggaaac tgctccgcaa tcagcttcgc cgctttctgc tcgctgatgc
     4081 ggtagtggtc cgccacgtcg ccggtctcgc ccaggttaag cccggcaatc agcaggtttt
     4141 tcagcgcgta ctggtcgaga tcgcggaaca gattcagctg cgccggtttc cccggccgca
     4201 gatccagcag ggtgaagtcc ggacagtgcg cccggaagac gtgcggcgcc catgcgtccc
     4261 ctttggggtc gaagtacacc accgcgtccc cgaaatcgcg tacgcagcga atgagcgcgt
     4321 tggtggccat cacgctcttg ccgctcccgg gcaggccgag gatctgaatg ttggtcttgc
     4381 gccaggtatc acgcggaacc agcaccggct tgccctgctc atccttaccc agaaacaccg
     4441 cctgctcctg ccgggcctgc tccgaggaaa aatcggccag cgcattaacc ggtaccggct
     4501 ccccgaaatg caggtggcgc acgtcggtca tctctcctgt ccgctggctg ctgcgccggc
     4561 tctcctgatt cagtttcgcg ttcaccgcct cgtcagcagc cgcaaaatga ccgtcaagca
     4621 gcaggaacgc cagcagccgc gccaacacaa tcccgacagc cagcccgccc gcgcaccagg
     4681 caatcccgaa caggttagcc ggctgcagca ggtaataatc tgcgtttgcg tagaggtccg
     4741 gacgcaggac ggtttctccc cagctctcga taaacacggc gacaaccagc ccccccagaa
     4801 gggccagacc ggccgcgccg gtcagccagt acgcgtagtt ccagacatgt cgacgtgccc
     4861 tgaccatccg cccgggcgaa tccagcgagg ccagcaccga aaatggcgct ggccgtttat
     4921 tatcgcgctt atagcgatcg gcatactccc gtcgctcctt atgactcagc cccacaaaac
     4981 gcatccgtcc ggcccaaagt tcagccagac cgaaaaacag gccgataact aggaaagccc
     5041 cggccagacc gtaatactcc tggtacagcc agctgaccca cggataaatc tgccgggcca
     5101 gctccggaat gtgccacttc caggcaagcg aatccgtatt aaacatgttc tctctccttc
     5161 agacgatggt ttgccggcgt gatgtgcagc ccccgctgca caagccgcgg acatgcccca
     5221 aggcatggcg gcggcggtca cgtccgtggt gattgcgttc agctttcacc acggaggcca
     5281 gcctctttcc gccccatgcg gaaaaggcgc agccccggag gaacaacgag cacgccccag
     5341 cgtgtgagag gaaaaggcgg caccccagtg cggtcttttc cggtgttccg gcccccgtca
     5401 gagttcgcca tagcgagcgg ctgaccaccc gcaaaatcag gagcagcttt gctgcttcgc
     5461 caggtgcgtc cagcaccgtg gatttttgtg ggtggtcagg cgtgagcctg acgggggccg
     5521 ggtgaatttc tggcgtggcc ggcgtccagc cggacggagc cagaaagagg gggagagacc
     5581 gtgcgtcggt ggcgtccagc cagcgtaagc aggggatatc cccctgaggt cagccacgcc
     5641 ctcgcgggga tgacctgtat ttctccgtaa ggagaaaaaa gcaacagaga taggttaacg
     5701 taaaatgttc agcgaaaaac cgatatgatt cacctatcct ggtaatttat tatcagggaa
     5761 tataaagact taatcagggg acaatatgcc acatcagcgc gtccggtgtc cgtcttgtag
     5821 gtgccgggga aattgcgcct cctcgctcac tcggtcgcta cgctccggcc gtgagactgc
     5881 ggcgggcgct gcggacacat gcaaagttac ccacagattc cgtgaataag caggggacta
     5941 acatgtgagg caaaacggca aggccacgca ggtggcgttt ttccataggc tccgccctcc
     6001 tgactgagtt cacataaaca gacgcttttt cggtgcatct gtgggagccg gtggctcaac
     6061 catgaatcag tcaggagtgg cgaaacccga caggacttaa agatcatcac cgtttccgat
     6121 gaatcgctcc ctcttgcgct ctcctgttcc aaccctgccg tttcccggat acctgttccg
     6181 cctttctccc ttgcgggaag tgtggcgctt tctcatagct cacactctgg tatctcggct
     6241 cggtgtaggt cgttcgctcc aagctgggct gtaagcaaga accccccgtt cagcccgact
     6301 gctgcgcctt atccggtaac tgttcacttg agtccaaccc ggaaaagcac gcaaaacgcc
     6361 actggcagca gccattggta actgggagtt cgcagaggat ttgtttagct aaacacgcgg
     6421 ttgctcttga agtgtgcgcc aaagtccggc tacactggaa ggacagattt ggttgctgtg
     6481 ctctgcgaaa gccagttacc acggttaagc agttccccaa ctgacttaac cttcgatcaa
     6541 accacctccc caggtggttt tttcgtttac agggcaaaag attacgcgca gaaaaaaagg
     6601 atctcaagaa gatcctttga tcttttctac tgaaccgcga tccccgtcag ttcagaggag
     6661 gacgatggtg ccaccgttcc accctgaaca tcccggatat agtttgcctg acatgcgacc
     6721 agaagaaagc ctgaaaaaat caatataaaa agaaaaacaa cctttacctt tttcatatac
     6781 cttccctgta tttaaaaacc ccggtattca tccctgaaca ccggaagtct gtatttcaaa
     6841 tcatccttga taacttttgc ttaccagtta ccatcccggt aaacaaagga tacaaagtaa
     6901 tcaaatttac taatatcgat tacattttta aagtgtggct gtaatatcga aacccatgat
     6961 ttttcaacat caaaccaacc attattaata ttatccttta aaggcatccc cagactttca
     7021 atgacagaac catcatcacc gaagtctttt gagtattcac cacctttaaa ctcttcggtt
     7081 ttcttatcaa accaatgaat atgtaattta agccccatat ttacctctta aagatatttt
     7141 ttaatgtttc gttttggatc cggcccttta acctgcttac ccgtttttgg atcgaatgcc
     7201 ccgaggtgtt cgccatcact ggcgcggtac ccttcaagct caccgtgctg ggaatcccat
     7261 tcataaattt tacgcttttt atcaccatac catcgggccc gcttaccacc accaccttgt
     7321 ttaggggttt taggtttacc ctctttcaac tctcccaacc ccttaatatc ttcagtcttg
     7381 ggatcaggaa aataatcatg gccgtaatct ttagttccct tacgaggttt tttcttttcc
     7441 tcatttaatt tattttctgc atccttcgct tttttctcct tttgtttccg gctctccatc
     7501 gccccggaaa gcgcagcctt atccctggat aaggattcat tcatttcgtt taaagatgtc
     7561 tgggcagctt ttaatttctc attctgattc tgaatatcct tatcaagata gcgaacctga
     7621 tcctgccacc cggagccata ttcatgaggc gggttataag tcacaaaatc atctttattt
     7681 gcctctgcct cttttacctt tttatcggct tcctgaacag cagcccttgc accggggatc
     7741 gccttctctg tcgatgcaat gcgactgttt aaggtcgcaa tatttttatc ttcagcatcc
     7801 agctcagctt tcgctttatc atactctctt ttcagcccct cttccgggtg agcagcgtcc
     7861 catgcctgct ggcgacgctt ttcttcctcc agacgctgtt ttacctgtgc cggagtaaga
     7921 acatccgtca ccgacacata gaccggtttc tgtccgctct ctttcgggaa acgaataacg
     7981 gcttcacggg agttaccacc ggccgtaaaa ccagccggac gtgaatcacc tttttcagca
     8041 ataatgcctt ttggcggggc tttcgcggcc ggaacacctt taggtacgct cacctgcaga
     8101 gacgggagac ccggaatcga cacactgaat acccccggac gttttgtcgg tttcgcatcc
     8161 accacaggaa cactcattgg ccggccggtg acaaccgcaa tatgctgccg ctcgtccttc
     8221 acaatatccg ccacacgttt agtgacgctg accgtcgcct ggtccagcgg cagggagctg
     8281 accggcgtct ccgttaccgt gtctgccggc aatgacgtca cgatttttga catcattttc
     8341 ggatcatctt ttgctatctc agaaggcagc actccgtaaa tcgcaatccc ccacagacca
     8401 aacttaaacg gacctttcag ggcagccagc acatcagcaa cagcggccga caacgcatcg
     8461 ccggaaacgg ataaagccag tccttcagcc cccggagtgg ccaaggcagg cagaccgaag
     8521 gccatcgcgg tggccgaaga ctgtccgcca ccagagctcc cgctatgatt gccgctgtta
     8581 ccgccattac caccgggttt actcccgccg ttaccaaact cccccgggtt atagttatga
     8641 atatccccgt taggtgtatg cgtcgtaccc cagcccggcc cgctgtttgg atccgtacca
     8701 ccacctgatg aagggccacc tttacctgat gtaccgttca cattcccact ggcctgacca
     8761 ccattgtgtc ccagacctga attacccgga cctcgtccgt ctccgccact catatacttt
     8821 tcctctttga cttttaaaac aataaactaa aataaaatac tgtacatata accactggtt
     8881 ttatatacag tataaaaatt acgctgcctt gtttttcatg tcaagtctgt aaatttgcgt
     8941 ttttgtgaaa atgatcaaaa aaacagccac tcacaccatg cgcaatcccc tccagatgca
     9001 acaaaaacca gcacaaacgg cgccgttctc cggcctcagt atgttttact gaaatcatta
     9061 tatgagatac cagaaagccc cctccgggac aggaaaagaa acggggggtc tggttcgggt
     9121 tgttcggtca ctgaacacgg tcagaaactg atgataagat agcctgcgga tatataactc
     9181 aatgagaaaa aagaattaaa ggtaaggaga cgctcatgag acgttccggc agcaaactgt
     9241 gtcttatcgc catgataaca gcgacagcaa ctctcactgc ctgtgctcca aagggcagcg
     9301 tggaacagca tacccggcat tacgtatatg cttcagatga cggttttgat cccaattttt
     9361 ccacccagaa agctgacaca acacgaatga tggtgccttt tttccggcag ttctgggata
     9421 tgggcgcaaa ggataaagcg accggaaaat cacggagtga tgtgcagcaa cgcattcagc
     9481 agtttcacag tcaggaattt ttaaactcac tccaaggcac aacacaattt gcgggtaccg
     9541 attaccgcag caaagacctc acaccgaaaa aatcaaggct actggctgac accatttcag
     9601 ctgtttatct cgatggctat gaaggcagac agtaagtgga tttaccataa cgcgtcatta
     9661 cgcgcaccgc tcagacgggc tcagggcgtt tccggcggct acgggataaa acaggcaaca
     9721 acccccccgg aaaactgccg gaaacgcgcc cgataaattt tatcctaatg catgcctatg
     9781 cacgcaactg catggcatat gttttgacgt aaaatggatg ccgtaagccc ttttttaccg
     9841 actttctgct tcatcagcct gactgacacg accatattct ttcagaccgc cccctgctaa
     9901 acttccttca tattgccgca ttaacccggg aggctccgca atgagcaaca ctacacacta
     9961 cgaaaacgcc aactttcttc gggaactggc tgaaagcctg ccccgcatac tgccggaagg
    10021 tggcccggac aaagctgcgc tgttgcagcg actggctaac gaagaactgg cccaggcaga
    10081 gtatgaagat caggttcgcg ccaaagtgac cgccgcccgt gctgacacgc gtccgggtat
    10141 gaccacggaa caactccgcc agcgcctgca tggccgttat caggaactgc gcgatgccgt
    10201 atgacgtgga atggaagcag ggagccatcg aggatgtaac gacgctgttt gactatatcg
    10261 cggaaaattc atccctgtgg gatgcgcaga acgttaccga ccgggttctc gctgcggcgg
    10321 acaaactggc cgacttcccg cgactctatg aagtggactc acgctatggc gaggacgttc
    10381 gccggatcag tctgatggga cagcatgtcc tctatgatgt tgatgaccag accagaaaag
    10441 tccgggttct ggccgtggtc ggccagcgcc agaatcccca tattggggtt ctaagcggga
    10501 atcccagaaa attccgtcat tccgtatgat gaaaattcag tcgactcctc gcttgacgtg
    10561 acgagcgcca aaagcctgcc gcatctgcct ggcgcgctcg agctcatcgc catgcaaata
    10621 catcgacgtc gtggcgatcg acgcatggcg taggttgtcg cgcaccgcgg tgagctgagc
    10681 tccccgggcc aacgcatggc tggcatgact gtgacgcatc caatgaggcg tggcacggcg
    10741 cagcttttcg gcggcgaccg gatgatcggc ctcaatggcc tcagcggctt gcgtaaagaa
    10801 tcttcgcaac acgcaccaaa ggtgagggcc ggtgatgccg gcattaccgt cttccccaag
    10861 actgcccacc aggggcgttt tcggattcca ccgttcccgg ctgactggca gttgacgctg
    10921 tgccaagtat tggtccagcg ccgtatacgc gagcggcggc aaggccacct tacctggttt
    10981 gccacctttg ccaaccaaat gcagccagtg gtcaccgtgc tcgtcgaggc ggacattacc
    11041 caggacggcg ccgaccagtt cgctagcgcg caggcccgtg gcatagccga agtcgagcat
    11101 gaagcgcagg cgttgtgctg ccggctcgga ccagccgtag gaccattcca ggccgtctgc
    11161 aatggcgcgc agcagtagcc attctccctc ggtaaagcct cgcgccgtat ccagtgcggg
    11221 ccgcaaggcg tgaccgcgta ccttgacgcc ggcgaaaggg ttggccagca catagcgctg
    11281 ctcgatgagc caccggaaca gcgccgagag caccgtcagc gcatacgctg ccgagcgtgc
    11341 ggacaagccg cccgagaagg ggcgccattc caccgaatcg cgtggtcgag gtggccccac
    11401 ccaacgctcg cgcggggtcg ggtgccggac aaaggcccgg tacgcgattg catcgtccgt
    11461 ggtcagggat gatagcgccc gtccgcgttc gacgatggcc cacaggatta gccgcgcagc
    11521 ctccttgcga taggcgcgct gtgtggcgac agtctcgtgc agcgccagcc aggcctgcac
    11581 ggcctcgtag tcgttggtcg cattcagcgt gcaagcgttg cgcggggccc ggaaattgcc
    11641 ctgcgagccg tcgacttcgt tcggcagacg caactgctcc cacggcacga tgccgctggg
    11701 ctgaataatc gggatcaggg cccgggcgcg ctcggtgagc tgcggatgtg cggcaaagaa
    11761 agcctcgacc tgccgggcgc ctgtcatgcc gagtccctcg atggctttcc accagccacg
    11821 ccggcgggga atgcgcacgg tcagcgccga gagggtgtgg ataccgtacg cctgcagtgc
    11881 cctgacggtc ctcggagaca gccactggtc gatgctgtcg ctgatctggg gcttcggcgc
    11941 cggcagcgtg ggcaagagcc ggatcgcgcg ttcgacggca cccgcgcgcc cctgtcgctc
    12001 ttcgggggcg tgctggaaca cgtcggccag atccggccgg tggcggctgt tggcgaaaac
    12061 gatgagctgg cggcggatat gccccagcat ccctcgcgct gattgaccgg cggccttgcg
    12121 tgccgccagg tagtgttcaa cggccgcgcg agagctgagt cccgcgtacc agccgcgcaa
    12181 ggcagccagc gaatccgcat cgggaaagcc gactggggta gaactcgaag ccgtagtctg
    12241 gcccgttttc atatggacag gttgcgattc gaaaagcgag taacgcgata ataacgatta
    12301 tttcagtaga atcgaaaatg ccccatgttt ctacgaaacc tcaagatagc aagaacgggc
    12361 catgagcaag aagaacaagc tactcagcgt cctatccgac gccgaacagg aggccttgta
    12421 tggcctgccg gagttcgatg atgcgcagca gctggaatat ctggctgtga cagaaaccga
    12481 gttggcgctt gccaacagcc ggcccagtct tcatgccaag gtctattgcc tcttgcagat
    12541 cggctacttc aaggccaagc atgccttctt cagtttcgac tgggacgaag tcgaggacga
    12601 ttgcgctttc gtgctgagcc gctatttcca cggcgaggtg ttcgaaccca aggcgatcac
    12661 caagcatgaa cgctacaccc agcgcgagca gatcgccaaa ctattcggct actggccgtg
    12721 gtcggccgcc ttcctgccgc agctcgagca gcaggccgca cggaccgtgc ggcgtgacgt
    12781 aacgccgggg ttcgtcgccg ccgagctgat cgtctggctc aatgagcaca agattatccg
    12841 gcccggctat acgaccttgc aagagttggt cagcgaaacg ctatccgccg agcgccggcg
    12901 cctgggcaat ctgctggagc aagcgttgga cgaatctgcc aaggccgcgc tgagccagct
    12961 tctggtccgt gatgacaccc tgtcgcaact ggcggcgctc aagcaggacg ccaagaattt
    13021 cggctggcgc cagatggtcc gcgagcgcga aaagcgcgcc acgctggagc cgctgcacgc
    13081 aatcgccaag acactgctgc ctaaactcga cgtctcgcag cagaacctgc tgtactacgc
    13141 gagcctggca aacttctaca ccgtccacga cctgcgcaat ctgaaggccg atcagaccca
    13201 actctacctg ctgtgctatg cctgggtacg ctaccggcag ctctccgaca acctggtcga
    13261 tgcgatggcg taccacatga agcagttgga ggacgaaagc agcgctggtg ccaaacaatc
    13321 ctttgccgac gagcaggtgc gccgtcagca ggaaacgccg cgggtaggcc gcctgctgtc
    13381 actctacgtt gatgatagcg tggccgatcc cacgcccttc ggcgaggtgc ggcagcgcgc
    13441 ctacaagatc atgcctcgcg atacgctgca aaccacggcg cagcgtatga gcgtgaagcc
    13501 ggcgagcaag ctggccttgc agtggcaggc ggtggacggg ctggccgacc gcatgcgccg
    13561 ccatcttcgt ccactgtacg ttgcgctcga cctctccggc tccaatccag acagtccatg
    13621 gcttgccgcg ctggcctggg ccaaaggtgt ttttgccaag cagcagcggc tgtcgcaacg
    13681 gccactcgac gagtggcccg cggcgacact tccgaaacgc ttgcggccgt acctgctgac
    13741 cttcgacgcc gacggtaaac caaccggcct gcacgctgac cgctacgagt tctggctgta
    13801 ccgccagatc aggaagcgtc tccaatcggg tgaactctac ctcgacgaca gcctgcaaca
    13861 ccggcacttc tcagatgaac tggttgagat ggacaggaag atcgatgtgc tcgcaaaaat
    13921 ggagatcccc ttcctgcagc aacccgtcca tgcccaactc gatgcgctga ctgccgaact
    13981 gcgcacgcag tggctggcgt tcaaccgcga gctgaaacag ggcaagctga cgcacctcga
    14041 atacaacaag gacacgcaga aactgacctg gcgcaagccc aagagcgaga atgagaaagc
    14101 gcgcgaaaag gcattctacg agaagcttcc gttctgcgac gtggccgacg tgtttcgctt
    14161 cgtcaacgac gagtgcaagt ttctgtcggc gttcacgccc atgcagccgc gctacgcgaa
    14221 gaaggtcgcc gacgctgaca gcctgatggc ggtcatcatc gcgcaagcga tgaaccacgg
    14281 caaccacgtc atggcgcgca ccagcgacat cccgtaccac gtgctggata gcggctacca
    14341 gcagtacctg cgccaggcaa cgctgcacgc ggccaacgac tgcatcagca acgccatcgc
    14401 cacgctaccg atcttcccat actactcgtt cgacctcgaa acgctgtacg gtgccgtcga
    14461 cgggcagaaa ttcagcgtcg aacggccgac cgtgaaggcg cgctattcgc gcaagtactt
    14521 cgggcgcggc aagggcgtgg tcgcctacac gctgctgtgc aaccacatcc cgctcaacgg
    14581 ctacctgatc ggcgcgcacg actacgaggc ccaccacgtg ttcgacatct ggtatcgcaa
    14641 cacgtcggac atcatgccga ccgcgatcac cggcgacatg cacagcgtca acaaggccaa
    14701 cttcgccatc ctgcattggt ttggccggcg gttcgagccg cgcttcaccg acctcaacgc
    14761 gcaattgaaa gaactctact gcgctgacga tccagcacag tatcaggcgt gcctgattcg
    14821 gccagtcggg aaaatcgact gcgatctcat ccatcgcgag aagccgaaca tcgaccggat
    14881 cgtcgccaca ctcgggctga aggaaatgac gcagggcacg ctgatccgca agctgtgcac
    14941 ctacaccacg acgaacccga cgcggcgcgc gatcttcgag ttcgacaagc tcatccgcag
    15001 catctacacg cttcgctacc tgcgcgatcc gcaactggaa cgcaacgtgc accgctcgca
    15061 aaatcgcctc gagtcctacc atcagctacg ctcggccatt gcccaggtcg gcggtaagaa
    15121 ggaactgacc ggtcgcaccg acattgaaat cgagatcagc aaccagtgcg cacggctgat
    15181 cgccaacacg atcattttct acaactcggc aatcttgtcg cggctggtga ccaagtacga
    15241 ggcggccggc aacagcaagg cgctggcact catcacaaaa atttcgcctg cggcatggcg
    15301 gcacatcctg ctcaacgggc actacacctt tcaaagcagc ggcaagacga tcgatctcga
    15361 tgcgatcgtc gcaggcctgg aactggagtg acggaatttt cagcggttcc gtgttagcag
    15421 cagtgtaaaa ctgacccacc ccagcgaagt aaaactgatc cacctgggct agtttggcgg
    15481 ccttttcgag gccgtcgatg ttgacccagg agcaaaccgt ggaaatcaga gttcttgccc
    15541 gacagggcca ctccatccgg cacatcgccc gcacgttggg ggtctcgcgc aataccgtgc
    15601 gccgctacct ccgcgatccg tcggtagcgc gataccagcc ccgtgaacca cgccccacca
    15661 aactggggcc atttgaatct tatctgcggc aacgggtcga gcaggcccac cccatctggc
    15721 tgcctgccac cgtcctgaat cgggaaatcc gcgctcaagg gtatggcggc ggtctctcgt
    15781 tattgcgcgc cttcctcgcc acgctcaagc ccgcccgccg cgaagcaggt ccggccgtcc
    15841 gtttcgagac cgagcccgga cggcagttgc aggctgattt cgtggtcttg cgccgggcca
    15901 gatcccccat gtcggccttc gtcgccacgc tgggatacag ccgcatgacg tttgtcacct
    15961 tcgtaccgga cgaatccttc gagtccgtgc gggactccct gttgctggct tttgactatc
    16021 tgggcggtgt gccccgcgag gtgttgttcg acaacatgaa gaccgtggtg ctggaacgcg
    16081 atgcctacgg tgacggcaag caccgttttc accccggctt gcttcaactg gccgatgacc
    16141 tggggttccg gatccggctg tgtcgcccgt atcgggccca gaccaaaggc aaggtcgagc
    16201 gcttcaatcg ctacttccgc gagagcttct acaacccgtt gctgacccgg atgaagggca
    16261 cggggctgct gctcgattgt gctgctgcca accgacgcgt ccgtgactgg ttggcagacg
    16321 aggcgaatgt gcgggtccac gccaccctga acgagcgccc catcgaccgt tggcggcagg
    16381 agcgggaaca cctgcaaccc ttgccatccc gtgtgcggcg cgacgaggcc cccctgctgg
    16441 ataacagtct ccgcccggta ccactggaat ctctccagca cccactgtct gtctatgacg
    16501 caattgggga ggcctgccga tgaacctcca gcatgagcgg atcgacgccc tgtgccagca
    16561 actcaaactc gaacgggtgg caacgcatta ccccgtcctg gcgcagcagg cggtgcgcga
    16621 ggacttcagc ttcaccgact tcctggaaca cctgttgcgg catgaagcgg ggtgtcgcca
    16681 gcagcgcagc cgcgaactgc tgacgcggat ggcttgcttc ccgggcatca agaccctgga
    16741 ggactatgac ttcagcttca accccggcgt gcccaaggca ctggtgcagg agctgggcag
    16801 tctggcgttt gtcgaacggg ccgagaacgt ggtgctgatc ggaccctctg gcatcggcaa
    16861 gacccacctc gccatcgcct tgggttacaa ggccgcgcaa gccggggtca agacacgctt
    16921 catcacggca gccgacctga tgctgcaact gagcacggcg cagcgacaag ggcggctgaa
    16981 ggaatacttc aaccgcgcca tcctcggtcc acggctgctg gtgatcgatg agatcggcta
    17041 cctgcctttc ggacgcgagg aagcgaacct gttctttcag gtggtggcga agcgctatga
    17101 gaaaggggcg atgatcctga cctcgaacct gccgttcagc cagtgggccg acgcgtttgc
    17161 cggcgatacc accctgacag ccgcgatgct ggatcggctg ctgcaccatg cccatatcct
    17221 gaccctgagc ggcgaaagct accgcttgaa ggacaagagg aaggcgggag tggtcaggaa
    17281 aaattccaaa cccgaatgat ccaggtgggt cagtattact ttggtgattc aggggtaaag
    17341 tgggtcagtt ttcagttggt gttgacaccg gcgtaccctc ggtgctatct tcgcgcccca
    17401 atagtcgggg cttggccagg acttcctgag gccgtccgta acgtggatgc cgaggtcagg
    17461 cgaggtggcc gacccatgaa cgccgacctg attcgttttt caatagcgct ggacgttgtg
    17521 gtgccaggga cttaccaacc cgatgtgtgc ccatccgggg cagttacagc cgttacagcc
    17581 tctggagagg gagcggcttg ccgctcggtg ataatcccag ctgtagcggc ctgattacat
    17641 ccggccgcta cacctagctc caccttcaaa caaggaatat cgttgatgtc actgtatcgc
    17701 cgtctagttc tgctgtcttg tctctcatgg ccgctggctg gcttttctgc caccgcgctg
    17761 accaacctcg tcgcggaacc attcgctaaa ctcgaacagg actttggcgg ctccatcggt
    17821 gtgtacgcga tggataccgg ctcaggcgca actgtaagtt accgcgctga ggagcgcttc
    17881 ccactgtgca gctcattcaa gggctttctt gctgccgctg tgctggctcg cagccagcag
    17941 caggccggct tgctggacac acccatccgt tacggcaaaa atgcgctggt tccgtggtca
    18001 cccatctcgg aaaaatatct gacaacaggc atgacggtgg cggagctgtc cgcggccgcc
    18061 gtgcaataca gtgataacgc cgccgccaat ttgttgctga aggagttggg cggcccggcc
    18121 gggctgacgg ccttcatgcg ctctatcggc gataccacgt tccgtctgga ccgctgggag
    18181 ctggagctga actccgccat cccaggcgat gcgcgcgata cctcatcgcc gcgcgccgtg
    18241 acggaaagct tacaaaaact gacactgggc tctgcactgg ctgcgccgca gcggcagcag
    18301 tttgttgatt ggctaaaggg aaacacgacc ggcaaccacc gcatccgcgc ggcggtgccg
    18361 gcagactggg cagtcggaga caaaaccgga acctgcggag tgtatggcac ggcaaatgac
    18421 tatgccgtcg tctggcccac tgggcgcgca cctattgtgt tggccgtcta cacccgggcg
    18481 cctaacaagg atgacaagta cagcgaggcc gtcatcgccg ctgcggctag actcgcgctc
    18541 gagggattgg gcgtcaacgg gcagtaaggc tctgaaaatc atctattggc ccaccaccgc
    18601 cgcccttgcg ggcggcatgg attaccaacc actgtcacat ttaggctagg agtctgcgcg
    18661 gcagagccgt gtgaccggtt ttctgtagag cactgacgat ggcggcggcg ctctctgcaa
    18721 ttggcaaggc gtcggcgcca aggataccaa tcttgcggcg cgcggcgtgt tatgacgact
    18781 ggggtgcatt tgagccgccc catttaacct tcgccctcac agatacgcca ttcgcctcag
    18841 atttagcgcc atgcagacga gcttccactc ggcttgcacc ttgtccaggc ccctcatgct
    18901 gaactgacgc aatcccatca ccgccttgat ccaaccattc ggagcctcca cgatcgactt
    18961 gcgccggcgg taagctgcat cgccttgctc cgttttcaat ttcgccgcaa tcgccgccgt
    19021 atgcggatgg gtcttggcat tgaccttggc atcttcacgt ccctcgcggc cgagggcaac
    19081 gatgacatcg ccgtggtgat cggcgacctt tgccagaaca gcctcactac ggaatcccgc
    19141 atccgccagc gtctgggccg gcatttctcc ggtgttggcc tgaactgctg ccagcatgcc
    19201 cagcagcgcc tgactgtccg cggcgcagtt ggtcaactcc gccgccacga tgatctggtg
    19261 ctcggcatcg accgctgtgt acccgttgta gctctgctcg gagcc
//
