LOCUS       NZ_CP033986            25519 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Staphylococcus aureus strain P2D1C1 plasmid unnamed4, complete
            sequence.
ACCESSION   NZ_CP033986
VERSION     NZ_CP033986.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN10374694
            Assembly: GCF_009739695.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 25519)
  AUTHORS   Liu,J., Gefen,O., Ronin,I., Bar-Meir,M. and Balaban,N.Q.
  TITLE     Rapid evolution of tolerance in patients infected with S. aureus
            promotes antibiotic resistance
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 25519)
  AUTHORS   Liu,J., Gefen,O., Ronin,I., Bar-Meir,M. and Balaban,N.Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-NOV-2018) Racah Institute of Physics, Hebrew
            University, Givat ram, Jerusalem 91904, Israel
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 1.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 594x
            Sequencing Technology             :: PacBio + Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 03:04:23
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,889
            CDSs (total)                      :: 2,807
            Genes (coding)                    :: 2,716
            CDSs (with protein)               :: 2,716
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 91
            CDSs (without protein)            :: 91
            Pseudo Genes (ambiguous residues) :: 0 of 91
            Pseudo Genes (frameshifted)       :: 50 of 91
            Pseudo Genes (incomplete)         :: 42 of 91
            Pseudo Genes (internal stop)      :: 35 of 91
            Pseudo Genes (multiple problems)  :: 32 of 91
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP033986.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..25519
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="P2D1C1"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="unnamed4"
                     /geo_loc_name="Israel: Jerusalem"
                     /lat_lon="31.7732 N 35.1853 E"
                     /collection_date="2017-10-03"
                     /collected_by="Shaare Zedek"
     gene            complement(join(25357..25519,1..143))
                     /locus_tag="EFD76_RS14470"
     CDS             complement(join(25357..25519,1..143))
                     /locus_tag="EFD76_RS14470"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid recombination protein"
                     /protein_id="WP_000122363.1"
                     /translation="MSYSIIRVVKVKSKTNTRGIQRHIQRENKNYENIDIDLSKSYLNY
                     DLVNDTKFDFNKKIDEKIEKNYKGKRKIRTDAIKHIDGLITSDNVFFNQLSEEETK"
                     /name="plasmid recombination protein"
     gene            complement(381..1007)
                     /locus_tag="EFD76_RS00045"
                     /old_locus_tag="EFD76_00050"
     CDS             complement(381..1007)
                     /locus_tag="EFD76_RS00045"
                     /old_locus_tag="EFD76_00050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000593103.1"
                     /translation="MIKLENVFVKKGNKNILDGCNFNFEKGKSYALVGESGAGKSTLLN
                     IIAGFEDVSQGSIYIEDKLLKKKVDFYRYTLGYLFQNFALLENQTISQNLDLALKFKKN
                     KKDNMNLKKEVLKKVGLDLDIKRIVSSLSGGEQQRVALARLILKDPKIILADEPTGSLD
                     TKNGKIVIDLLLKLLDENKTMIVVTHDLELAKRFDVIVNISELRS"
                     /name="ABC transporter ATP-binding protein"
     gene            complement(1019..1330)
                     /locus_tag="EFD76_RS00050"
                     /old_locus_tag="EFD76_00055"
     CDS             complement(1019..1330)
                     /locus_tag="EFD76_RS00050"
                     /old_locus_tag="EFD76_00055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YxeA family protein"
                     /protein_id="WP_000831610.1"
                     /translation="MKRTLIIVTIVLLIIILSLLLVRNEHLDRFNPLLKEKVSYAKVPK
                     DTQDYRNITVYSKNGEKKSYKLDFLGYDPTKEYVKVNHKGKYVRSIEYITKDIPSFLK"
                     /name="YxeA family protein"
     gene            complement(1334..3268)
                     /locus_tag="EFD76_RS00055"
                     /old_locus_tag="EFD76_00060"
     CDS             complement(1334..3268)
                     /locus_tag="EFD76_RS00055"
                     /old_locus_tag="EFD76_00060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001670421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="WP_000713729.1"
                     /translation="MKKFKLFLDFSTLLLISGLLFLFFFKENEEIIPESSNILTISNWD
                     KSNSKSKVLDVIESGAKNQNIQIIKSVKDFDNKKEFFVFNSKRNNSDFIRNKTSLLTPS
                     DLLNREIKGKYYIIGEHFNVEELTSELKKAGLTSEVEYINRNILFFELVIDNDLLVPFI
                     FLGVLYLLYFLYDRGYNLKFYAIQKLHGFSTTRIIFHNIHIKIIYWLVLTAIFFIANIL
                     IIHIANLELDFLMFIRRFIVLLFVFACITTLLWLISYSLLLKLSIPLILKGKKGYKFSI
                     FMGTFTKCIMVLILSFLLAQNLNAYTKLKNIYDSEKIWQKLDNYYTLEISPNIRNSEEK
                     QILETNIYNLIKKSEQLGGLLLKNNNIANPDKNNYIPENGNVFFINNNFLNFYKNINHD
                     FKMIDNHSDKINVFIPPRLQYQKSEIQKNHQGWIDFQKQQNKKVDVQVLSKNVSVFSFD
                     RTTNLKFGYLDSPIVMLLTLDDLTGDFYLAAVSQGGYLFKDLDTLKQLLKDNHLEEEIS
                     GITNYKDSVLNELNETKTKMIITIVTIIINVFILLIATVFETIQYFSWNKKQLLLRKIH
                     GYSLFSSNVRYLTISILLSIMLAYTTHILFGSKILLFIIMSIAIIQHLLQIAYIKYLEK
                     YFKDLMREI"
                     /name="bacteriocin-associated integral membrane family
                     protein"
     gene            complement(3343..3636)
                     /locus_tag="EFD76_RS00060"
                     /old_locus_tag="EFD76_00065"
     CDS             complement(3343..3636)
                     /locus_tag="EFD76_RS00060"
                     /old_locus_tag="EFD76_00065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_000726502.1"
                     /translation="MKKKFVSSCIASTILFGTLLGVTYKAEAATVHVAGGVWSHGIGKH
                     YVWSYYSHNKRNHGSTAVGKYSSFSGVARPGVQSKASAPKAWGGNKTFYSLH"
                     /name="lactococcin 972 family bacteriocin"
     gene            complement(4050..4658)
                     /locus_tag="EFD76_RS00065"
                     /old_locus_tag="EFD76_00070"
     CDS             complement(4050..4658)
                     /locus_tag="EFD76_RS00065"
                     /old_locus_tag="EFD76_00070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002436987.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001566953.1"
                     /translation="MIVGYARVSSNDQNLERQLENLKTFCAEKIFTEKQSGKSIENRPV
                     LQEALNFLRMGDRFVVESIDCLGRNYDEVIHTVNYLKDKEVQLMITSLPMMNEVVGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRI
                     IYHRVVEMLEEGQSISKIAKEVNITRQTIYRIKNDNDLI"
                     /name="recombinase family protein"
     gene            complement(5027..5872)
                     /gene="blaZ"
                     /locus_tag="EFD76_RS00070"
                     /old_locus_tag="EFD76_00080"
     ARG             complement(5031..5872)
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            5979..7736
                     /gene="blaR1"
                     /locus_tag="EFD76_RS00075"
                     /old_locus_tag="EFD76_00085"
     ARG             5980..7733
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="97.26"
                     /coverage="100.0"
     gene            7726..8106
                     /gene="blaI"
                     /locus_tag="EFD76_RS00080"
                     /old_locus_tag="EFD76_00090"
     ARG             7727..8103
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            8370..8948
                     /locus_tag="EFD76_RS00085"
                     /old_locus_tag="EFD76_00095"
     CDS             8370..8948
                     /locus_tag="EFD76_RS00085"
                     /old_locus_tag="EFD76_00095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690623.1"
                     /translation="MKIGYARVSTGLQNLDLQEDQLNQYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLIILVNELNNRGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLKLLKTLYDNGTPI
                     KTIAEQWKVSRTTIYRYLNKLNNQENKDK"
                     /name="recombinase family protein"
     gene            9075..9686
                     /locus_tag="EFD76_RS00090"
                     /old_locus_tag="EFD76_00100"
     CDS             9075..9686
                     /locus_tag="EFD76_RS00090"
                     /old_locus_tag="EFD76_00100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000583532.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000583532.1"
                     /translation="MIIGYARVSSIDQNLERQLENLKTFGAEKIFTEKQSGKSIENRPV
                     LQEVLNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKDVQLMITSLPMMNEVIGNHL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKDKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGQAISKIAKEVNITRQTVYRIKNDKGLCW"
                     /name="recombinase family protein"
     gene            complement(10039..10458)
                     /locus_tag="EFD76_RS00095"
                     /old_locus_tag="EFD76_00105"
     CDS             complement(10039..10458)
                     /locus_tag="EFD76_RS00095"
                     /old_locus_tag="EFD76_00105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418034.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_000418036.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNNYFANLTNEETVVFKKILLKINETTF"
                     /name="MarR family transcriptional regulator"
     gene            10582..11553
                     /locus_tag="EFD76_RS00100"
                     /old_locus_tag="EFD76_00110"
     CDS             10582..11553
                     /locus_tag="EFD76_RS00100"
                     /old_locus_tag="EFD76_00110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="WP_000481285.1"
                     /translation="MFNAVVVRKSASNVSYKVETVDESYLSKGDVLVKVVYSSINYKDM
                     LALQYNGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILRKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGN
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVCVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(11725..11817)
                     /locus_tag="EFD76_RS00105"
                     /old_locus_tag="EFD76_00115"
     CDS             complement(11725..11817)
                     /locus_tag="EFD76_RS00105"
                     /old_locus_tag="EFD76_00115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001791613.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            12100..12879
                     /gene="ser"
                     /locus_tag="EFD76_RS00110"
                     /old_locus_tag="EFD76_00120"
     ARG             12101..12876
                     /name="ser"
                     /gene="ser"
                     /gene_name="staphylococcal enterotoxin type R"
                     /tool="amrfinderplus"
                     /drug_class="nan"
                     /identity="99.61"
                     /coverage="100.0"
     gene            complement(12969..13775)
                     /gene="sej"
                     /locus_tag="EFD76_RS00115"
                     /old_locus_tag="EFD76_00125"
     ARG             complement(12973..13775)
                     /name="sej"
                     /gene="sej"
                     /gene_name="staphylococcal enterotoxin type J"
                     /tool="amrfinderplus"
                     /drug_class="nan"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(13932..14099)
                     /locus_tag="EFD76_RS14420"
     CDS             complement(13932..14099)
                     /locus_tag="EFD76_RS14420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000144396.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000144396.1"
                     /translation="MTFSLLTKVAMSGLILTGAIGTAGLVSVPVANVEAKAAEFNPKVD
                     KLLKFEVSKK"
                     /name="hypothetical protein"
     gene            14670..15445
                     /gene="sed"
                     /locus_tag="EFD76_RS00120"
                     /old_locus_tag="EFD76_00130"
                     /pseudo=""
     CDS             14670..15445
                     /gene="sed"
                     /locus_tag="EFD76_RS00120"
                     /old_locus_tag="EFD76_00130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_128623913.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="staphylococcal enterotoxin type D"
                     /name="sed"
     gene            <15442..15682
                     /locus_tag="EFD76_RS14475"
                     /old_locus_tag="EFD76_00135"
                     /pseudo=""
     CDS             <15442..15682
                     /locus_tag="EFD76_RS14475"
                     /old_locus_tag="EFD76_00135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002484888.1"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1002 domain-containing protein"
                     /name="DUF1002 domain-containing protein"
     gene            16040..17077
                     /locus_tag="EFD76_RS00125"
                     /old_locus_tag="EFD76_00140"
     CDS             16040..17077
                     /locus_tag="EFD76_RS00125"
                     /old_locus_tag="EFD76_00140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001645037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4238 domain-containing protein"
                     /protein_id="WP_001173532.1"
                     /translation="MALGILSKLAMAGIVLTSVTGAATLGGVSSIAHEVHAEENANQEH
                     FEKTLEGKVLNFKDVLSKNTISIKDFSKAVENELKNKGFDPSEYKLKFKVKVGHSVYQS
                     SDGGNLIVGNEHIGTATAEFNPTKHKLGVYESEIEKIIDYIIKNITSKDLDVSVNMQNK
                     IFQYIHLQYLRTDAGRINFMNLIENPFTYKPRKKPIDLDEIQKHKNTIIKFNEIFKQGN
                     NLENLLKRMKKPSNMNFHIAISEDNLLTSDNPVIATDNWNQIMLPITPNILIEFQEDKI
                     NSSNDLRVILKKNKTRYVNEATINTANYFIISNKEFTRYQYKYIDNRFNNKNWEIGYPH
                     VNLKN"
                     /name="DUF4238 domain-containing protein"
     gene            complement(17280..17375)
                     /locus_tag="EFD76_RS00130"
                     /old_locus_tag="EFD76_00145"
     CDS             complement(17280..17375)
                     /locus_tag="EFD76_RS00130"
                     /old_locus_tag="EFD76_00145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000493114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_000493115.1"
                     /translation="MFSTLFVTIIAPIVVGVILTLFSHWLNNREK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(17541..17888)
                     /locus_tag="EFD76_RS00135"
                     /old_locus_tag="EFD76_00150"
     CDS             complement(17541..17888)
                     /locus_tag="EFD76_RS00135"
                     /old_locus_tag="EFD76_00150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000119691.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNQEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(17907..18524)
                     /gene="cadD"
                     /locus_tag="EFD76_RS00140"
                     /old_locus_tag="EFD76_00155"
     ARG             complement(17911..18524)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="99.51"
                     /coverage="100.0"
     gene            complement(19735..>20017)
                     /locus_tag="EFD76_RS14480"
                     /old_locus_tag="EFD76_00160"
                     /pseudo=""
     CDS             complement(19735..>20017)
                     /locus_tag="EFD76_RS14480"
                     /old_locus_tag="EFD76_00160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199895.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(20028..20704)
                     /locus_tag="EFD76_RS14425"
                     /pseudo=""
     CDS             complement(20028..20704)
                     /locus_tag="EFD76_RS14425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /name="replication initiator protein A"
     gene            21115..21858
                     /locus_tag="EFD76_RS00155"
                     /old_locus_tag="EFD76_00175"
     CDS             21115..21858
                     /locus_tag="EFD76_RS00155"
                     /old_locus_tag="EFD76_00175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_000843758.1"
                     /translation="MKSVKRLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESATEDKQKKESDNINFESKSDAQIVEILKNQINTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNAR
                     QNVDAQEKTYTTSPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAQREDVSANPND
                     NDSDIEEKSEETEPKKGFWSRLFGN"
                     /name="DUF536 domain-containing protein"
     gene            complement(22077..22262)
                     /locus_tag="EFD76_RS00160"
                     /old_locus_tag="EFD76_00180"
     CDS             complement(22077..22262)
                     /locus_tag="EFD76_RS00160"
                     /old_locus_tag="EFD76_00180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000466619.1"
                     /translation="MFGDQRQEATKYVIKEGYQDIYFLNKNGEWYYFEVRSVWRGKHII
                     RVKDGLLGWRKEIVTE"
                     /name="hypothetical protein"
     gene            22411..22482
                     /locus_tag="EFD76_RS00165"
                     /old_locus_tag="EFD76_00185"
     CDS             22411..22482
                     /locus_tag="EFD76_RS00165"
                     /old_locus_tag="EFD76_00185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_106873653.1"
                     /translation="MNEILVHIMTTAISGCLVTLFGY"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(22721..23062)
                     /locus_tag="EFD76_RS00170"
                     /old_locus_tag="EFD76_00190"
     CDS             complement(22721..23062)
                     /locus_tag="EFD76_RS00170"
                     /old_locus_tag="EFD76_00190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761340.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000761341.1"
                     /translation="MKLAEAIKEQRELKGWSQEELANILKVSRQSVSKWESAKNYPSLD
                     ILIAMSDLFGISLEHLIKGDARFKKVILEGNYRESNRVPSIVDFLYDFWWLFFPVAGFL
                     VWAIHSFMG"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(23149..24009)
                     /locus_tag="EFD76_RS00175"
                     /old_locus_tag="EFD76_00195"
     CDS             complement(23149..24009)
                     /locus_tag="EFD76_RS00175"
                     /old_locus_tag="EFD76_00195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_000145511.1"
                     /translation="MTGETVVYKNEMNLVPLRRFTATEINLFFAMCNKLKEQDTNTLRL
                     SFDELKKLSNYSPETRNINRFANDLDNVYKKMLNLTIRYEDDDVIERFVLFNHYRIHKR
                     EQYLEISTSSNLKHILNSITNNFTKFELKEMTRLKSTYSKNMFRLLKQYKHTGYLKIHI
                     DDFKNRLDIPKSYRMTDINKNVFKPIIIELGSIFNNLTINKIKAKKGRKIEWIEFTFDA
                     EKRIHNKRQPQMSKIDKSRQYVRREKTPKWLEERSYEKQPQKDYDPQLEKEREDFLKQL
                     ELNWE"
                     /name="replication initiation protein"
     gene            complement(24394..24939)
                     /locus_tag="EFD76_RS14485"
     CDS             complement(24394..24939)
                     /locus_tag="EFD76_RS14485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001805533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000273005.1"
                     /translation="MYEIKTKNVGGWFHKEKQETGNIVITKTDFEKYTKQIKAAQMILD
                     DYECIKSGKSLKKAEKQNESLVNELTSVHMENEKLVEEFNDLAQRYNYLLSENEKKDKE
                     LNYTLKLFNQVFKIIKSMMKEERYHTLINHIDNHLDNSKIREVMTIDNNDEQFFKKKYQ
                     AQEREIIFKEDREDGYTL"
                     /name="hypothetical protein"
     gene            complement(25033..25332)
                     /locus_tag="EFD76_RS14490"
     CDS             complement(25033..25332)
                     /locus_tag="EFD76_RS14490"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid recombination protein"
                     /protein_id="WP_000390798.1"
                     /translation="MEEEYGKENLLYATVHMDEITPHMHYGVVPITKDGRLSAKEVVGN
                     KKALTEFQDRFNTYINKQGYDLKRGISRQLTKEKHDQVSRYKQKTEYHKQMHMR"
                     /name="plasmid recombination protein"
     ARG             complement(5028..5872)
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     BGC             1..8636
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(19531..19678)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="81.333"
                     /coverage="100.0"
                     /evalue="2.96e-25"
     Typing          21116..21858
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(23150..24009)
                     /name="rep_cluster_2214"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(4..143)
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="91.489"
                     /coverage="99.0"
                     /evalue="2.99e-16"
     Typing          complement(25388..25518)
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="97.727"
                     /coverage="99.0"
                     /evalue="1.03e-18"
ORIGIN
        1 actaaatcat agtttaaata tgacttactt aaatcaatat ctatattttc ataattttta
       61 ttttctcttt gaatatgtct ttgaatacct cttgtatttg tttttgattt cactttaaca
      121 actcgaataa ttgaataaga cataataaat caacttccac tgcatatgat tataacacct
      181 aaacacagaa aagttttaac atactagact tattaaaaac caaataagtc attaaaaacg
      241 tgtgctctgc gaggcttgtt ttttgtcatc ataaaaaagg actggaaaat ccagtcctta
      301 aattaaaaaa ctcaaaagta atgactaatc atatttcata ttgttttttc tctatgtatg
      361 gctataccta tcaatatttc ttaacttcta agctcagaaa tattgactat gacatcaaat
      421 cgtttcgcaa gctctaaatc atgcgttacg acaatcatag ttttattttc atcaagtagc
      481 ttcaataata aatcaataac tatttttcca tttttcgtat ctagtgaccc agtaggttca
      541 tcagctaaaa tgattttcgg atcttttaat attaatcttg ccaatgctac tctttgttgt
      601 tcaccaccgc ttagagaact aacaattctc ttgatatcta aatctaggcc gacctttttt
      661 aatacttctt tctttaagtt catattatct tttttattct ttttgaactt tagggctaaa
      721 tctaaatttt gactgattgt ttgattttca agtaaagcaa aattttgaaa caaataccct
      781 aacgtatatc tataaaaatc gactttcttt tttagtaact tatcttcaat atatatgctt
      841 ccttgtgata catcttcgaa cccagcgatt atgttaagta aagtagattt tccagcgcca
      901 ctttctccaa ctaaagcata tgattttcct ttttcaaaat taaagttaca tccgtctaaa
      961 atgtttttat tacctttttt tacaaaaaca ttttcaagtt ttatcactat cggtcacctc
     1021 attttaaaaa gctaggaata tcttttgtaa tgtattctat cgaacgcaca tatttccctt
     1081 tatgatttac tttcacatat tcttttgtag gatcataacc taaaaaatcc aatttataac
     1141 tctttttttc tccattttta gagtatacag ttatatttct atagtcctgg gtatcttttg
     1201 gaactttggc ataagatact ttttctttta acagtgggtt aaaacgatct aaatgctcat
     1261 ttctaaccaa taacagacta agtatgatga ttaatagtac aattgttaca ataattaaag
     1321 ttcttttcat tgtttaaatc tccctcatta aatctttaaa gtatttttca agatatttaa
     1381 tataagcaat ttgaagtaaa tgttgaataa tagcaataga cattattatg aatagtaata
     1441 tctttgaacc aaataaaata tgcgtagtgt aagctaacat aatagaaagt aagatagaaa
     1501 ttgttaaata acgtacatta ctgctgaata atgaataacc atgaattttt cttaataata
     1561 gttgcttttt attccagcta aaatattgaa ttgtttcaaa tacagtagct atcaaaagaa
     1621 tgaaaacgtt aataataata gtaactattg ttattatcat ttttgttttc gtttcattta
     1681 attcatttaa cacagaatcc ttgtaattag ttataccgct aatttcttct tctaggtgat
     1741 tatctttaag caactgttta agtgtatcta aatctttaaa tagatatcca ccttgagaaa
     1801 cagcagctaa ataaaaatct cctgttaaat cgtcaagtgt caacaacatt actattggag
     1861 aatctagata cccaaatttc aaattagttg tgcgatcaaa agaaaaaaca gatacgtttt
     1921 ttgacagtac ttgcacatct acttttttgt tttgttgctt ttgaaagtca atccatcctt
     1981 ggtgattttt ttgaatttca gatttttgat attgtaacct tggaggaata aacacgttta
     2041 ttttatccga atgattgtca atcattttaa aatcatgatt tatattttta tagaaattca
     2101 gaaaattgtt attgataaaa aagacattgc cattttcagg aatgtaattg tttttatcgg
     2161 gattggctat attattattc tttaaaagca atccaccaag ttgttcgctt ttcttaatta
     2221 aattgtatat attagtttct aaaatttgtt tttcttctga atttctaata ttaggagaaa
     2281 tctctaatgt atagtaatta tctaactttt gccagatttt ttcagagtca tatatattct
     2341 ttaacttcgt ataagcattt aaattttgtg ccagtaaaaa agatagtatt agcaccatga
     2401 tacatttggt gaaggtaccc ataaatattg aaaacttata tccttttttc ccttttaaga
     2461 ttaatggaat acttaacttc aaaagaagac tatacgaaat cagccacagc aatgtagtaa
     2521 tacaagcaaa aacaaaaagc aacacgataa atctacgaat aaacattaag aaatccaatt
     2581 ctaaattggc tatatgaatg attaatatat tagcaataaa gaaaatagcg gtaagtacta
     2641 gccaataaat gatttttata tgaatattat gaaaaataat gcgtgtagtt gaaaagccat
     2701 gtagcttttg aatagcataa aatttcaaat tatatcctct gtcatataag aagtacaaaa
     2761 gatataatac gcctaagaat atgaaaggca ctaataaatc attatctatg actaattcaa
     2821 aaaataatat gtttctattt atgtattcaa cttcagatgt taaaccagct ttttttaatt
     2881 cactcgtaag ctcttctaca ttgaaatgtt caccaataat ataatacttt ccttttatct
     2941 ctctgtttaa taaatctgat ggagttaaaa gtgatgtttt attacgtata aagtcagaat
     3001 tatttcgttt tgagttgaaa acaaaaaatt cttttttatt atcaaaatct ttaacggatt
     3061 taattatttg tatattttga tttttggcgc ctgattcaat gacatctaac acttttgatt
     3121 tactgttaga tttatcccaa ttagagattg ttaaaatatt ggaactttca ggtataattt
     3181 cttcattttc tttgaagaaa aataaaaata atagccctga aattaataat aaagtactaa
     3241 aatctaaaaa taatttgaat tttttcatat tgcctctttc aagagaatag acagaattaa
     3301 gtttacttaa ttctgtctat tctccttaat taatatatgt aattagtgaa gactataaaa
     3361 tgttttgttt ccaccccaag cctttggagc agatgcctta gattgaacac caggtcgagc
     3421 aacaccacta aaagatgaat atttccctac tgctgttgaa ccatgatttc ttttattgtg
     3481 actataataa gaccatacgt aatgttttcc aataccatgg ctccaaacac caccagctac
     3541 atgtactgtt gcagcttcag ctttataagt tacacctaat aaagtgccga ataagattgt
     3601 actagcaata caactagaaa caaatttctt tttcataaaa acacctccat ttaatattct
     3661 ttatttatta tagcaaaaat aaataaaata gagaatgagt aaaaataatc taaaagtgtt
     3721 ttttctgctc tgttgcttgt tttgttcatc tatatataat attaattcta ttatccttaa
     3781 attaactatc attaaacaac gatatgacaa tgtataataa atacaatttc actacctata
     3841 attcaacatt atataaacta aagtatttca aataattaac tgtattaata ctctcatcat
     3901 gattgcgtta taaacattcg ttaatgagaa aaagagagag catatttacg ctctcttttc
     3961 ttgtcttatt attaaaaact cataatagat tataatcatc tgttttgaga cgctgtgaga
     4021 agctctcagt tgcattgaaa caaagtttat taaatcaaat cattatcgtt tttaattctg
     4081 taaatcgtct gccttgttat atttacttct ttcgcaattt tactaattga ttggccttct
     4141 tctaacattt ctacaacgcg atgataaata atacgtttct gtggatcttt agcatttggt
     4201 gaataaagta aggggcgccc tttatatacg cctttttcct tcgcaacttg aattccttgc
     4261 gcttgtcgac gtttactttc atttctctct tgttctgaaa ccattgctaa tatttgaata
     4321 attaaatctt tcataaactt atccagtaat ggattgccaa ccacttcatt catcataggt
     4381 aagctagtaa tcattaattg tacttctttg tcttttaaat aattaacggt atgaatcact
     4441 tcatcataat tacgacctaa acaatcaatg gattctacta caaaccgatc tcccatcctc
     4501 aaaaagttaa gtgcttcttg aagtactggt ctattttcaa tagatttccc agactgtttt
     4561 tctgtaaata ttttttcagc acaaaacgtc tttaaatttt caagttgtct ttctaaattt
     4621 tgatcgttcg atgatactct cgcatagcca acaatcattg atttccatct cataattaat
     4681 atacacccta atcatacgtt tcagttacta taaattcaac aattatgtca ctttgcttga
     4741 tatatgagaa ttatttaacc ttataaatga gaaaaaagca acgcacttta aataagatac
     4801 gttgcttttt cgattgatga acacctataa ttaaactatt catctattat ttatgatttt
     4861 ttgtatatac aatatttcta gtttgttaaa gagaattaag aaaataaatc tcgaaaataa
     4921 taaagggaaa atcaggtttt gatatcaaaa ttatacatgt caacgataat agaaaatata
     4981 atacaaacta taagatgtta tcagtattta ttatgcattt agaatattaa aattccttca
     5041 ttacactctt ggcggtttca cttatcaact tatcatttgg cttatcactt ttattgtctt
     5101 tattcgtaaa aatgactaaa acaataggtt cagattggcc cttaggataa acaaaagcaa
     5161 catcatttct agaagcatat gttattgctt gaccactttt atcagcaacc ttatagtctt
     5221 ttggaacacc atctttaatt aaagtgtctc cgtttttatt attaaacatt aaatcaagta
     5281 agaaattttt attttttttg cttaattttc catttgcgat aagtttattt aaagtcttgc
     5341 cgaaagcagc aggcgttgaa gtatcttttt tgctctttgg cgaatagtaa tttaattcta
     5401 tctcatatct aactggattt gttactttat ctcctagttc ttttagacgt tgtttaactt
     5461 ttttgattcc accgatttct tttataattt tattgtttgc tgtattatca ctatatgtca
     5521 ttgaagcctc aataagttct tttaaagtga tgtcttttcc tacatatttt tctaaaatag
     5581 gagaataagc aactatatca tctttgttaa tatgtacttt tttatttaac ttattataag
     5641 gtacttgttc taacaaaata gcactattta tcgcttttga agtcgaagca taggcaaatc
     5701 tcttatctga attaaatttt acttccttac cacttttagt atctaaagca taaacaccaa
     5761 tatgagcatt atattttttt tctaaatcat ttaactcttt ggcatgtgaa ctgtttgaat
     5821 tacatgcact taaaactaaa gccattacaa ttaaaaatat taactttttc aaaataaacc
     5881 ctccgatatt acagttgtaa tttttacaaa acaataatat tacaattgta atattgatgt
     5941 caattgttta ttataaatat ttgaaagaag gtgtcaaaat ggctaaatta ctaataatga
     6001 gtgtagtaag cttttgtttt atatttctat tgttagtatt ttttaggtac atattaaaac
     6061 gctattttaa ttatagttta aattataaag tttggtatct aactgtgctt gctggattaa
     6121 ttccttttat cccaattaaa ttctctttta taaaatttaa taatgtgaat aatcaagcgc
     6181 ccacagttga aagtaagtca cacgacttga accataacat aattaccacc aaacctgttc
     6241 aagagttcgc aacagatatc cataagttta attgggattc aattgataat atctgcacag
     6301 ttatttggat agttttagtt attattttaa gttttaaatt tttgaaagcc ttattatatc
     6361 ttaaatattt aaagaaacag tcactttatc taaacgaaaa tgaaaaaaat aaaatagata
     6421 cgatactttt caaccatcaa tataaaaaaa atattgtgat tcgaaaagca gaggctattc
     6481 aatctccaat aactttttgg tatgggaaat atattatttt gattcctagt tcatatttta
     6541 aaagtgtaat tgataaaaga ctaaaatata taatactgca tgaatatgct catgctaaaa
     6601 atagagatac tttacattta attatcttta atatcttctc tattgttatg agttacaatc
     6661 cattaataca tattgtaaaa agaaagataa ttcatgacaa tgaagtagaa gccgatagat
     6721 ttgtccttaa taatattaac aaaaatgaat ttaaaactta tgcggaatct attatggact
     6781 ccgtattaaa aacctcattt ttcaacaaaa atatattaag ccattcattt aatggtaaaa
     6841 aatcattact caaaaataga ttaattaata taaaagaagc cgatctgaaa aagcagtcaa
     6901 aattaattct aatttttatt tgtattttta ctttttttat catgataatt caaagccagt
     6961 ttttaatggg gcaatccata actgattata attataaaaa gcccttacag aacgatcacc
     7021 aaattttaga tgaaagtaaa aattttggtt caaatagtgg atctttcgtc atgtacagca
     7081 tgaagaaaga caaatactat atttataatg aaaaagaaag tagaaaaaga tattctcctg
     7141 attcaactta taaaatttat ttagcgatgt ttggacttga ccatcatatc ataagtgata
     7201 aaaattcacg tatgtcatgg aatcataaac attatccttt cgagtcttgg aataaggaac
     7261 aagatttaaa tacagcaatg caaaattcag ttaattggta cttcgaacgt attagtaatc
     7321 aaataccaaa gaactatact gcggctcaac tcaagcaatt aaattatggt aatgaaaact
     7381 tgggaagtta taaaagctat tggatggaag atagtttgaa aatatctaat cttgaacaag
     7441 taatagtttt taaaaatatg atggaacaaa ataaccattt tagtaaaaaa gcaaagaatc
     7501 aattatcttc ttcattattg attaagaaaa atgaaaagta tgaactgtat gggaaaacag
     7561 gtacaggtat agtaaacggg aagtataata atgggtggtt tgtaggttac gtaattacaa
     7621 atcatgataa gtattatttt gctacacatt tatcagatgg aaagccgtct gggaaaaatg
     7681 ctgaattaat cagtgaaaaa atattaaaag aaatgggtgt tttaaatggc caataagcaa
     7741 gttgaaatat ctatggctga atgggatgtt atgaatataa tatgggataa aaaatcagta
     7801 tcagctaatg aaattgtagt tgaaattcaa aaatataaag aagttagcga taaaacgatt
     7861 agaacattaa tcacaagact atataaaaaa gagattataa aacgatacaa atcagagaat
     7921 atttattttt actcatcaaa tattaaagaa gacgatatta aaatgaaaac tgctaaaacc
     7981 tttcttaata aactgtatgg aggggacatg aaaagtttag tgctgaattt tgcgaaaaat
     8041 gaagaattaa ataacaaaga aattgaagaa ttgcgagaca ttttaaatga tattagtaaa
     8101 aagtaattag agatatgttt caaacataat acatatgtaa actatgcttg actcttatta
     8161 aattagtttt gttaataaca tttaaaatat attattaaat atgagagtgt ccagaaaatg
     8221 gttattttct ggacactctc tttttatatc tagatatata tctattatac atattttagt
     8281 gttcaataac ccaacagaaa atctatgttc ataaatatgg ttagaattaa gttatgatac
     8341 aatgaaaatg tatataggag gtttgtatct tgaaaatagg ttatgcaaga gtttcaactg
     8401 gattacagaa cttggattta caggaagatc agttaaatca atatggttgt gaaaagatat
     8461 ttaatgatca tatgagtggt tcaaaaagta agcgacctgg tttagataaa gccattgaat
     8521 ttgcgaggtc aggagatacg attgttgttt ggagactaga tagactagga cgtaacatgg
     8581 aagatttaat catattagtt aatgaactta ataatcgagg cgtgagtttt catagtttag
     8641 aagaaaatat aacaatggat aaatcaagtt ctacaggaca attgttattt catttattcg
     8701 cagcatttgc agagtttgaa cgtaatttaa ttttagaacg ttcttcagcg ggacgaattg
     8761 cagctcgtgc tagaggacgc tatggaggtc gacccgaaaa attaaataaa caagatttaa
     8821 aattactcaa aacactttat gataatggaa caccaattaa aactattgca gagcaatgga
     8881 aagtttcacg tacaacaatc tatcgttatc tcaataagtt aaataaccaa gaaaataaag
     8941 ataaataata ttactaaatt ttaagaaaga taaaaattag acaggataca ccctaaccat
     9001 acaaaaagaa ttgttgaaat tataacaatt aaaatgtatg attagggtgt atattaatta
     9061 tggagtgaaa ataagtgatt ataggttatg cgagagtatc ttcgatagat caaaatttag
     9121 aaagacaact agaaaattta aaaacgtttg gtgctgaaaa aatatttaca gaaaaacagt
     9181 ctgggaaatc tattgaaaat agaccggtac ttcaagaagt tcttaatttt gtaagaatgg
     9241 gagatcgatt cgttgtggag tctattgacc gtttaggacg taactatgat gaaattattg
     9301 aaactgtgaa ctatttaaaa gaaaaagatg tacagttaat gattacaagt ctacctatga
     9361 tgaatgaagt gattggtaat catttactgg ataaatttat gaaagattta atcattcaaa
     9421 tcttagcaat ggtttcagaa caagagagaa atgaaagtaa acgtcgacaa gctcaaggta
     9481 ttcaagtcgc aaaagataaa ggtgtatata aaggacgtcc tttactctat tcaccgaatg
     9541 cgaaagatcc tcaaaaacgt gttatctatc atcgagttgt cgaaatgtta gaagaaggac
     9601 aagcaattag taagattgcg aaagaagtta atattacaag acagacagtt tatagaatta
     9661 aaaatgataa gggattatgt tggtaaatgg attgtcattg caaatgagcg tttctcacag
     9721 cgtcccaaaa tatatgttaa tcatgtatta tgagatttta ataataagac aggaaaaaga
     9781 gagagcaaat acgctctctc tttttttcta tattttttct caataacgac gatcgttatt
     9841 ggaatttaat ttctaatact tttttattag gaatacgcct acgatatttt tattatagag
     9901 gctaaagtat cttaaaaatt tggatagtag gtttttcagg aataaaagta tagttggctt
     9961 taatatataa ttaagctaag ctatcattta tatttactcg attataattc gcacttcaac
    10021 gttttaataa cgtaaaaatt aaaacgtagt ttcatttatc tttagtaata tctttttaaa
    10081 cactacagtt tcttcattag ttaaattagc gaagtaatta ttattaagtt gataggcttt
    10141 cttttctaat gttggccata agtcttttgc tttatttgta ctgtttatta gcacagttct
    10201 tctattttca ttatcagttt gacgtgttat tagatccttt ttggacatct tatctaatat
    10261 tccagatatt gttgaaggtt ctaaatttaa agtattacca atcgctttag gtgtattcaa
    10321 attactatta atcaagcaat tcaaaacacc atattctgct ggagtaatat tatagggact
    10381 taataaactt ttaaaatgtt taaacactct attctgagaa gtactcaaca aataatttat
    10441 acaattatct aattccacaa ctaaaacctc tcttaaatca ttagtattga ctcgcttatc
    10501 atatcatgat aagttttgta ggaaaatagt tttgcaacaa aaacatacct ctacaaaaca
    10561 attgtgaaag aaggctaata aatgttcaat gcggtagtag tgagaaaaag tgcatcaaat
    10621 gttagttata aagtagaaac cgttgatgaa tcttatttat cgaagggtga tgtcttagta
    10681 aaagtggtat actcttcaat aaattataag gatatgctag ctttacaata taacggcggt
    10741 gtaattagag attatcctat gattcctggt atagattttg caggtattgt tgaatcaagt
    10801 tcgaatgata agtttaaaga aggcgataat gtattagtta ctggttatga tgtcggcgtg
    10861 acacatacag gtggattttc agaatatgca caagtgcctg gagagtggat tgttcctatt
    10921 ccccaagaaa tgtctattaa agagtctatg gtatatggca cagccggttt tacggcagca
    10981 ttatcaattt ttgaactaga aaaatatgga atgaatatca aatcacaacc tgaaatttta
    11041 gtgtctgggg ctacaggtgg tgtgggcagt gttgctatac aaattttacg taaaattgga
    11101 tatgaaaata tcactgctat cgtaagaaaa gaaaagcaaa tagaaatcgc aaaaaaatta
    11161 ggtgcaaaac aagtaataat aattgaagat gataataaac cacttaaaaa aggtattttt
    11221 gattatttcc tagatacagt agggaataat gtaacattat acggtttaaa acgtctaaat
    11281 tatcaaggtg ttgctactgt atgtggaaat gtagcaggaa attcacttaa cgctaatata
    11341 ttaccgttta ttcttagagg tattaaatta attggcattg attctgtatg tgttgatcat
    11401 aatatccgtg aagatatatg gagtaagtta gcaaatgaat ggaatatagg aaattcactt
    11461 ctatacaatg aaattggatt tgaagaattc tataaaacga tagatcagct tttaaaagga
    11521 caacatttag gaagaactat tttaaaagta taagtatgag tattcattaa tatatttact
    11581 attaattcaa tcattttgca tttctctact aaccagtgtt ataatctaga taacgaaaat
    11641 gattaacaat taatgcacca atccccacac tattgcagta gtgtggggat tttttcgatg
    11701 ctggcttata aagtcgccta ttaattattt gttgcgttta ctaagccaat aagtataata
    11761 cgcaacagca cagccactga tgactggtgc tatgatgtga acgaaaatga ttagcaaagt
    11821 aatgcacctc ctctctgcgc ctaagttgac gactgagaga taggcgactt gtatattata
    11881 tcatctctga atattggatt gaatcgccta ctttcttaaa ttaacaacat ctattctcat
    11941 agaatttgtc taattaagtg tagacgattc agaagtatat tttttgagct tagatatttt
    12001 gctaaaatat gtttaaattg ttaacgtttc agcattttaa acattgccta attttataat
    12061 ctttatttat gttatattaa ataaaaaaga ggtgtattca tgttaaataa aatcttactt
    12121 ttattgctct ctgttacttt tatgttgtta tttttctctt tacattcagt aagtgctaaa
    12181 ccagatccaa gacctggaga attgaataga gttagtgatt ataaaaaaaa caaaggtact
    12241 atggggaatg ttgaatcctt atataaggat aaagcggtaa tagcagaaaa tgttaaaaat
    12301 actagacaat tcttaggaca tgatttgatt tttcctattc cttattcaga atacaaagaa
    12361 gttaaaagtg aatttataaa taaaaaaaca gctgataaat ttaaagacaa acggttagat
    12421 gtgtttggaa taccctattt ttatacatgt ttagtaccta agaatgaatc aagagaagaa
    12481 tttatttttg atggagtttg catatacggg ggcgttacaa tgcactccac agctgatagt
    12541 atatccaaaa atataattgt tccagttact gtagataata aacaacagtt ctcttttaca
    12601 attagtacaa ataaaaaaac ggttacggta caagagctag attataaagt aaggaattgg
    12661 ttgactaaca ataaaaaatt atatgaattt gatgggtcgg catatgagac gggttatatc
    12721 aaatttattg aagaaaataa agatagtttt tggtacgatt tgtttcctaa aaaggatttg
    12781 gttcccttta taccttataa atttgtaaat atttatggag ataataaaac tatagatgct
    12841 tcgagtgtta agatagaagt tcacctgact acaacgtgat tcatacggtt gatacttttg
    12901 atacttttga tagatgtact acgtatatga tttttttata gtaggttctg ctcttatttt
    12961 taataagtct acagaaccaa aggtagactt attaatacaa ttaggcttgt atataaatat
    13021 atatcgatat gcatgttttc agattctatg attttattat cttggtatat ttttaataat
    13081 ttgtctggat attgacctat aacattaaat aaatcataac taaccaacgg ttcttttgag
    13141 gtatgaaaca cgattagtcc tttctgaatt ttaccatcaa aggtactagg gttgtataaa
    13201 ttatattgtt tatgtaaata atatcttgcc tgaagatcta gttcttgaat ggttactttt
    13261 ttcttatttg ttttaactat atctagcgga acaacagttc tgatgctatc aatccataaa
    13321 ttaataggta tttttttagt atcataaagt tgattgtttt catgcagtgt tactccacca
    13381 tacatacatg ctgttttatt tggtttacca ccagaacatt gaaaaccata ataagatccg
    13441 tatagatcta cttgtttgcc tttaaactta ttaactgttt cttttgaatc gaattgtacc
    13501 aataagtcgt tatactgtga atgacttatg aaaaaacttt taaataatag tgtgtaatct
    13561 aaaaattgat cttctgtcat tatcttttca gagataccct tttcgttaaa gaagtatata
    13621 tgtctgaggt tatttaaagt aatactactt aactctgatt ttttgtgcaa attcttttct
    13681 ttaattgttt catttttgct atcgctgtaa actaaagggg ttattagtag tgttaacgtc
    13741 agggagaaaa tcagtataaa tattgttttt ttcattgtgt taactcctta aatataagtt
    13801 agctgcattt agtaatgctg gctgattctt ttatcatgca agactttaaa aaataggatg
    13861 ttgaaatatt gaagatagaa ataaatatta tacttaatca aattacttac aattaagaat
    13921 attttaagag attacttttt agaaacttca aattttaata atttgtctac tttgggattg
    13981 aactctgctg ctttagcctc aacattggca acaggcacac taactaatcc ggctgttcct
    14041 atggcaccag ttaatattaa tccagacata gctacttttg ttaataaaga aaaagtcata
    14101 gttatccttc tccattcttt tattattttt taacaactat actataaata catcatgatg
    14161 tatttatagt atagtttttt atattaaaat aaaattacta cgaattaata attattaaaa
    14221 tatttattta aaaaatattt aaataaatat aaagtatatt taaaatttta ttaatgatgg
    14281 tttcttcgat aaaatgtttt aattattaag agagacttga tctgtttaga ccaagtctca
    14341 aattattaaa gataatattt gttggagtgt atgaaatgga tcaaatatat tgatataatg
    14401 aaagtgagca agttggatag attgcggcta gtctcttgaa aaaagggatt cctatgttta
    14461 tagttggtac ttctaggaag gactagcatg tcttatttcg aaatgctgat ggttgtatta
    14521 acaattatga gtttagtctt aattagtaat caaaactctg aatgtattgt ctacataatc
    14581 ggtgtaacaa taatatatat ccgaaagatt aaagtactct ataaaagaat catttaaagg
    14641 tgctcaaatt tattgaaaaa aggtggaata tgaaaaaatt taacattctt attgcattac
    14701 tcttttttac tagtttggta atatctcctt taaacgttaa agccaatgaa aacattgatt
    14761 cagtaaaaga gaaagaattg cataaaaaat ctgaattaag tagtaccgcg ctaaataata
    14821 tgaaacattc ttatgcagat aaaaatccaa taataggaga aaataaaagt acaggagatc
    14881 aatttttaga aaatactttg ctttacaaaa aattttttac tgaccttatc aattttgaag
    14941 atttattaat aaacttcaat tcaaaagaaa tggctcaaca tttcaaatct aaaaatgtag
    15001 atgtttacgc tataagatat agcattaatt gttatggtgg tgaaatagat aggactgctt
    15061 gtacatatgg aggtgtcact ccacacgaag gtaataaatt aaaagaacga aaaaaaatac
    15121 caatcaattt gtggataaat ggtgtacaaa aagaagtttc tttagataaa gttcaaacag
    15181 ataaaaaaat gttaccgtac aagaattaga tgcacaagca aggcgctatt tgcaaaagga
    15241 tttaaaattg tataataatg atactctcgg aggaaaaata cagcgcggaa aaatagagtt
    15301 tgattcttct gatgggtcta aagtctctta tgatttattt gatgttaagg gtgattttcc
    15361 cgaaaaacaa ttacgaatat acagtgataa taaaacatta tccacagagc accttcatat
    15421 tgacatctat ttatatgaaa agtagtcaat tcaaatactt taacatcaga cactaaagcc
    15481 atttcaaaga atgctaaaga tttattaatc ggtatcgaaa aaattcagga gacttactag
    15541 ataaagcaaa agaaagagct aataatctaa atattgaaga aaacagaaac ttataaaaat
    15601 atggggtgga attttacaaa ttatacaagc tatcatcaat ttcttttcaa gcttatttaa
    15661 tcgtctttta ataaatgtgt aggagatttt agatgctatc aataacatag tcttaaagag
    15721 agttgtaacg aacgtaataa attataatag tagtttacct gggtcgaata aaacgatatg
    15781 caatgcattt gttgatgaca aaaaatgtat tacatatcta aattaatcca tagaaaatgc
    15841 caattcttga tataatatca ctttgcaaca gaaccgttgc cccatctcaa gtgccttcta
    15901 cttactttta atattcattt aatatattgt tgatgaattt ttaattgtaa tatacattat
    15961 ttaacttaat aattatattt catcattatg tgagcgcttt tagcgaacaa aaattaactt
    16021 agactagaga tggataaata tggctttagg tatattatca aaattggcaa tggcaggtat
    16081 tgttttaact agcgttacag gcgctgcaac tctaggaggc gtttctagta ttgctcatga
    16141 agtacatgca gaggaaaacg ctaatcaaga acactttgag aaaactttag aaggtaaggt
    16201 attaaatttc aaagatgtat tgagtaaaaa tacaatatca ataaaagact tcagtaaagc
    16261 agttgaaaat gaattgaaaa ataaaggctt tgaccctagt gagtataaac ttaaatttaa
    16321 ggtaaaagta ggacatagtg tgtatcaaag tagtgatgga ggaaatttaa ttgttggtaa
    16381 tgaacatatt ggcactgcaa ctgccgaatt caatcctact aaacacaaat taggggtata
    16441 tgaatctgaa atagaaaaga ttattgatta tattattaaa aatattacat ctaaggactt
    16501 agatgtttca gtaaatatgc aaaacaagat ttttcaatat attcatttac aatatttacg
    16561 tactgacgcc ggaagaatta attttatgaa tttaattgaa aatccgttta catataaacc
    16621 tagaaaaaaa cctatcgatc tagatgaaat acaaaaacac aaaaatacaa taataaagtt
    16681 taatgaaatt tttaagcaag gcaacaacct agaaaactta ttaaaaagaa tgaaaaaacc
    16741 atctaacatg aattttcata ttgcaataag tgaagataat ttattaacta gtgataatcc
    16801 agtaatcgct actgataatt ggaaccaaat aatgcttcca attactccaa atattcttat
    16861 agaatttcaa gaagataaaa ttaactcatc taacgattta agagtaatat taaaaaaaaa
    16921 taaaacaaga tatgtaaatg aagcaacaat taatacagca aattatttta ttatatcaaa
    16981 taaagagttt acccgttatc aatataaata tatagacaat cgctttaata ataagaattg
    17041 ggagattggt tatcctcatg taaatttgaa aaattaaaaa cttttctagc attatacata
    17101 ttacaacttt tgttccttct ttttaatact attgaaagat tgttttttgc atttctccac
    17161 taactagtgt tataatttag ccaacaaata gtgtactagc atgataaaca ccgagcccga
    17221 taactactgc gaatagttat cgggctcttt tggtgtatta actatatgtc gtcgctaaat
    17281 tacttctcac gattattcag ccaatgagaa aataatgtga gtataactcc tactacgata
    17341 ggagctataa tagttacaaa tagtgtactg aacatgatgt cacctccttc catgctaaat
    17401 acagcacaga agtaaacgac gacctttgta ttatatcatt tctaataatt gagttacaga
    17461 taacttccga taagtcgtct tatgttatat aactttgttt tttatagtat caagacaaga
    17521 agaaactcgt ttcactcgtt tcaaaaaccc tcctgatttt tagagaaaaa ctctcttatt
    17581 tcatcgtctt taataaaata atatgccatc tttccatctt tataaaaatc aagtacctca
    17641 tttttatata aaagccttaa atgatgtgaa gttgaagcaa cactcatttt caatatcaaa
    17701 gaaatatcac aaacacacaa ctcatcttct ttaatcaaag ataatatgat tttcaatttc
    17761 ttctcatcac aaattttttc taaaatgtta agtaatttct tagatttatc atcttctaaa
    17821 aaacttaaag cattgttaac tttatcctca tgtacacaga tcacatcaca agtattttca
    17881 taactcatat aaaatcacac cctaaattaa aatataaatc ctaaaattgt ttgaatagtg
    17941 tcattttcaa taataataaa taaacctaaa gctatataaa tgatagccat aatccaacga
    18001 ctaaatttct caacaatttc tccaattcct gggatattag ctaatttttg tgcagtaaac
    18061 accaagaaga aaattaaaat taaaaagaca aacagagtaa gtaataaatt agtaacactt
    18121 aatgtcacaa aatacggaac aaataaacca atattatcgg cgccacaact tgctatcgta
    18181 acaattgcaa ccgtaccaac taatttagac aatccttttt cattcaattc ttttttagct
    18241 ctcttttctc cttcacaatc atcataaata gccactttaa ttccaagata aattggtatt
    18301 aaacccaata aacctaatat ccacttttct ggaacataat ttaatacaaa agctaaaaac
    18361 aaactaacta atattaaaat aatagaccct aaatattgac caacataaat atttctatat
    18421 tcttttctag tctttgctct agcaaaaaat attaataaaa ttactaataa atcaactgct
    18481 gtagcaatat aaagaacagc agcagcaaca accgtttgaa tcataataca cctcattcaa
    18541 aaatattttt gaatgtatta taacttatat ttttaaataa tcataggtgc tttattccaa
    18601 ttgctttatt gacgttgagc ctcggaaccc ttaacaatcc caaaacttgt cgaatggtcg
    18661 gcttaatagc tcacgctatg ccgacattcg tctgcaagtt tagttaaggg ttcttctcaa
    18721 cgcacaataa attttctcgg cataaatgcg tgtctatgcg tagacatgga gacacttcag
    18781 aattatggag tgattacatg agtttaacta tttttcttta ttcagtttta ggaagtttat
    18841 tagcaaatta tatctacgaa aaatcttcaa aataaataac tttttcggtt ctactttgta
    18901 cactttatct acctggtaga cctaattgtt attgctttac aggtctaaaa ttcgtcgtta
    18961 taatctagtt aaatcccgta agggcgcact tatacgtcgg ataaatcgac atgtgcaaaa
    19021 acgtaatcga ccttcgtcga tttttttatt tcaaaattaa agaaacggct tgagatattc
    19081 cgagcagtta taaaaattaa tttgcgttga atattgctac tacattcttg aaaaagtgat
    19141 gtagatttat agcccataac ttttttgaat tacatcgacg atacggcgtc gaaagaaaaa
    19201 gctacctcac tttatctggg ggggctttta ttttttatgc ccttattttg aattttaaga
    19261 gggcatttta aagatttagg ggtgattcat atagttttat atctaaaact tatatacgct
    19321 tttaaaacgc aaatatgagc caaataaata tatgctattt tcaaaaacaa aaatttgagc
    19381 aaaaacaata actatttttt agacactgcc catttacatg caaattaaaa attagcataa
    19441 aattctttaa aacttcccca cgttcttcta aattcctgca gggcttttct tatcaaaaac
    19501 ttagaaattt taatttaact ctaaaatctc cgtaagagca taagggaaat ttgtccccat
    19561 caatgaatgg gggatctggc aaagccagat atttcaaggc ttcgaaaatg tttttgtgtg
    19621 gggtcataaa aagctcaagt gtcacacttt tgtgacacta catacagcat ttgtcacaaa
    19681 aataagacag cacttttttt acaaaaaagt aataaaaaaa gacatcagtt atcactaatg
    19741 ccttaaataa taattttgct tttcaaaatt gccgtaatcg aatgtgcctt ttcttcttca
    19801 tttgctattt tatcttcatc acttgtatta attaaattgc catcttcagc atcgtctaag
    19861 tttaaaattt tatgttttta tttaagcaat ccaccataac ttaacatacg ttttcgatac
    19921 aaatcttttt ctagatcact gacaatttct tgattttttc atcgctatca gttaaaaagt
    19981 cagatgattt aacgaaatat tttgatgtat ctttgattgt tataaaatca tttgaatgat
    20041 tgattaaaga tattatattg tttcatgttt ttacggcgca tataaagtgc atgtgtttct
    20101 tcaaattcag ttaaaattgt ttgcattaaa taaccttgca ttgacttgaa tgattactaa
    20161 tttcattttc ggactctata tcattcaagt cattcatatc atttatttca gtattgttag
    20221 attcagtata gctaagttca gtatcattag attctgtttt atcgacttct tgaagtcggt
    20281 ttttccgact tccttgccat tgctgctctc aacagtgttt tcttgctttt gaattttata
    20341 aatatcatct tctgttactt ctggtttaac taaataaagt ttatttgtct tatttaaacc
    20401 ttgtctttct tgtagtagta attcggcttc aattaagttc tttctttatt ttaattactt
    20461 tatctttttt acaatttaat atattttgtg gtttttcatt tttgtaataa aaataaaaat
    20521 tacctgtttt agaatcaacc caaccatttt taattgataa atctaaacga tctctaagaa
    20581 taccccatgc catttttgca tcattggata acttgatata tttaggattt gtaaaaaata
    20641 ctttcggtat ttgataaaac ttttctctgt attcctcatt tatgttgtaa agtttaattg
    20701 acataataaa aacctctttc cgaattttag tttggtaaga ggtaataaaa cgcttacatt
    20761 ttttgtgttt atttaataat ctaggtgctt gcactaagat attattcatt atataatcta
    20821 agtatcgaaa attatataaa taaacagttt ctaaacgttt tattaccaaa ccccgactat
    20881 taccagtagt tggggttttt gttatattaa ggttattata gcactttgaa taaacttaaa
    20941 aaagggaaaa tataggttta taaacctttg ataaacacca taaacccttt acaaaccctt
    21001 gataaaaagg ttggcgaatt tatattttta tttgtcgatt actttattat taatcgttat
    21061 aagcttataa tattttacta agggtttata aacattttat aaagggttga tgatatgaaa
    21121 agtgtaaaaa ggttgagtga agaattaggg gttagtaagc aaacgatttt taataatatt
    21181 aagagattga atatagagac aataaaacag gaaaacactt cgtttattaa agaagatacc
    21241 gatatagaaa aaatcattca aagagtaaat gaaaataaaa agaaatatgg ttttgaaagt
    21301 gctactgaag acaaacaaaa aaaagagtcg gataatatta attttgaatc taaaagcgat
    21361 gctcaaatag tagaaatact taaaaatcag attaatactt taaataatca aattgaaaaa
    21421 caagaaagtc gtcatgaaac aacaattgaa ttttacagaa aagagttgca agaaagatca
    21481 aaattgcttg agaatcagca agttctggca ttagagagta ataaaaagat tcaaaaatta
    21541 gaaaatcaat tagaaaaaga aaaacacctt aattatccct ttgatacatc tactaacgct
    21601 agacaaaacg ttgatgcaca agaaaaaaca tatactacta gtcctgtaaa tattaaccga
    21661 gatcaggaag aaactaaaga aacagagatt caatataagg atatatctgg aagtcaaagc
    21721 gacgaaagta cacaaggtga agaagcacaa agagaagacg tttcagctaa tccaaatgac
    21781 aatgatagtg atatagaaga aaagagtgaa gaaacggaac ctaaaaaggg gttttggagt
    21841 cgtctatttg gtaactaatt ttaattaaaa aggtacgaca agttcataaa ttagccgtgc
    21901 ttttttatgt gaattgaact tctgataatc atcgattatg ttaaccaaac aaaaagccat
    21961 aaatgcctat atgacggcat ttatggcttt ttactttcat tatcttttat gcatctttta
    22021 tacatcgttg atttgacgcg ttttcattct tttgcattgg caagtatttt gtatctttat
    22081 tcagttacta tttcttttct ccaacctaac aaaccatctt taactctaat aatatgtttg
    22141 ccacgccaga cacttcttac ttcgaaataa taccattccc cgtttttgtt gaggaaataa
    22201 atatcttgat aaccttcttt aatgacatat tttgtagctt cttgtctttg atcgccaaac
    22261 attatcaatc ccacccttat atttatttat ctttaatata taacaacatt tattaatatt
    22321 catgttattt catggaagga gagatttgtt ataatgtgaa ggtcgtctat ctctcagatg
    22381 tcaattcggc gtagagagga ggtgcgattt atgaatgaaa ttcttgttca catcatgaca
    22441 acggcaatca gtggttgtct cgttacgtta tttggttatt agctccataa acgtgataaa
    22501 aaataatata gacgattaaa gccaattcac caaaaaaccc cgaactacgg cgaatagttc
    22561 ggggttttgt gcgtttacaa acgaaattct tgttactttt agtatatatt tcatattgcc
    22621 ttttgtaaac tcttctattc ttatcaatac atttcaaggt gtcgtaaaaa tactttcctt
    22681 tttcatattg cctgatgtgc attaaatttt gattttaaaa tcaacccatg aacgaatgaa
    22741 tggcccaaac taaaaatccg gcaacaggaa agaaaagcca ccaaaaatca taaagaaaat
    22801 caactatgga aggtaccctg ttactctctc tataatttcc ctctaaaata acttttttaa
    22861 aacgtgcatc tcctttaatt aaatgctcta aagagattcc gaataaatcg ctcatagcaa
    22921 tcaaaatatc taaggaagga tagtttttgg cactttccca tttagaaaca ctttgtctgg
    22981 aaacctttaa tatattggct aattcctctt gagaccatcc ttttaattct ctctgttctt
    23041 ttatagcttc agctaatttc ataaaatcac tccttaactc aaactataat taaaataatt
    23101 gaaaagtcac gatactttta gttaaccaac tcgcaacgaa aagttgcgtt attcccaatt
    23161 cagttcaagt tgttttaaaa aatcctctcg ttctttctct aattgtgggt cgtaatcttt
    23221 ttgaggttgc ttttcatatg accgttcttc taaccattta ggcgtctttt cacgcctcac
    23281 atattgtctt gatttatcta tcttggacat ttgaggttgt cgtttgttat gaatgcgttt
    23341 ctcagcgtca aatgtgaact ctatccattc aattttacgc ccttttttcg ctttgatttt
    23401 attgatagta agattattaa atatagaacc taattcaata ataataggtt taaaaacatt
    23461 tttgttaata tcagtcatac gataagattt aggtatatct aaacgatttt taaaatcatc
    23521 gatgtgaatt tttaaatagc ctgtatgttt gtattgttta agtaatctaa acatattttt
    23581 agaatatgta gatttaagcc tagtcatttc ttttaattca aattttgtaa aattattagt
    23641 aattgaattc aatatgtgtt ttaaatttga agaagttgat atttctagat attgttctcg
    23701 cttatggatt ctataatgat tgaataaaac gaatctttct attacatcat catcttcata
    23761 tctaatggtt aaattcaaca tctttttata cacattatct aaatcattag caaatctatt
    23821 aatattacgt gtttctggac tataattact taattttttt aattcatcaa aagacaaacg
    23881 taatgtatta gtatcttgct cttttaattt attacacatc gcaaaaaata aattaatttc
    23941 agtagctgta aatcgcctta atggaactaa attcatttca tttttatata caactgtctc
    24001 tcctgtcatg atacagcccc cctttattac gaacctaaag gagtatcgtt tgaatataca
    24061 ctcccatttg aaaactttta ttcacaataa actactttat tatcaatgtc aaaccataaa
    24121 aggagtacaa ctttttaaaa cactcctttt atgtggcaaa aacactcctt ttatgtggca
    24181 aaaacactcc ttttatgtgg caaaaacact ccttttatgt ggcaaaaaca ctcctttagg
    24241 cattgaaatc ccttgttgct ctagggctga acaagcccct aaaaaggttt ttaaaaagat
    24301 ttataaaaat atattaaaaa gttcgagggg ggctacctat ttttcatcct aaaaaataat
    24361 taacctcaaa caaatgcatt taaatatcta tttttataat gtataaccat cttctctatc
    24421 ttctttaaaa atgatttctc gttcttgtgc ttgatatttc ttcttaaaga actgttcatc
    24481 attgttatct atcgtcatta cttcacgtat tttagaattg tctaaatgat tatcaatatg
    24541 atttattagt gtatgataac gctcttcttt catcatactt ttaatgattt taaaaacttg
    24601 attgaataac ttaagcgtat aatttagttc tttatctttc ttttcattct ctgacaacaa
    24661 ataattataa cgttgtgcta aatcattaaa ttcttcaacc agcttttcat tttccatatg
    24721 gacactagtc aattcattaa ctaaactttc attttgtttc tctgcttttt ttaatgactt
    24781 cccactttta atacattcat aatcatctaa tatcatctgt gctgctttaa tttgtttagt
    24841 gtatttttca aaatcagttt tagtaattac aatattgcct gtttcttgct tctctttatg
    24901 aaaccatcca cctacatttt tagttttaat ttcatacatg acactcagaa gctttttaag
    24961 cgtatctaat gatttttggt agttttgtat caatttatca ttttcttgct ttaaataatc
    25021 ctctatttgc ttctagcgca tatgcatttg tttatgatat tctgtttttt gtttataacg
    25081 gctaacttga tcatgttttt cttttgtaag ttgtctagaa attcctcgtt ttaaatcata
    25141 gccttgctta ttaatatacg tattgaatct atcttggaat tcggttaatg cttttttatt
    25201 acctacaact tctttcgcac ttaaacgtcc atctttagta ataggaacta cgccataatg
    25261 catatgtggt gttatctcat ccatatgtac tgtcgcatat aaaagatttt ctttaccgta
    25321 ttcttcttcc aagaacgctt tagcatgctt aaaaaactat tttgtctctt cttcagataa
    25381 ttgattaaaa aacacattat ctgatgtaat taatccatca atatgtttaa tggcatctgt
    25441 tctaattttg cgtttccctt tataattttt ttcgattttc tcatcaattt ttttattaaa
    25501 atcaaactta gtatcattg
//
