LOCUS       NZ_CP031889            27068 bp    DNA     circular CON 17-OCT-2023
DEFINITION  Staphylococcus aureus strain CFSAN082782 plasmid pMRSA_23, complete
            sequence.
ACCESSION   NZ_CP031889
VERSION     NZ_CP031889.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN09882578
            Assembly: GCF_008329865.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 27068)
  AUTHORS   Hoffmann,M., Sanchez,M., Worley,J. and Bry,L.
  TITLE     Whole genome sequencing of cultured pathogen
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 27068)
  AUTHORS   Hoffmann,M., Sanchez,M., Worley,J. and Bry,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-AUG-2018) CFSAN-ORS-DM-MMSB, US Food and Drug
            Administration, 5100 Paint Branch Parkway, College Park, MD 20740,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 10/17/2023 01:50:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,920
            CDSs (total)                      :: 2,841
            Genes (coding)                    :: 2,754
            CDSs (with protein)               :: 2,754
            Genes (RNA)                       :: 79
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 87
            CDSs (without protein)            :: 87
            Pseudo Genes (ambiguous residues) :: 0 of 87
            Pseudo Genes (frameshifted)       :: 45 of 87
            Pseudo Genes (incomplete)         :: 43 of 87
            Pseudo Genes (internal stop)      :: 18 of 87
            Pseudo Genes (multiple problems)  :: 18 of 87
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031889.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..27068
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="CFSAN082782"
                     /isolation_source="nasal perirectal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pMRSA_23"
                     /geo_loc_name="USA:MA"
                     /collection_date="2018-04"
                     /collected_by="Clinical Micorbiology Laboratory @ Brigham
                     and Women's Hospital"
     gene            join(26898..27068,1..759)
                     /locus_tag="D1E86_RS14760"
                     /old_locus_tag="D1E86_15090"
     CDS             join(26898..27068,1..759)
                     /locus_tag="D1E86_RS14760"
                     /old_locus_tag="D1E86_15090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074567.1"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA];
                     GO:0042626 - ATPase-coupled transmembrane transporter
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000793446.1"
                     /translation="MKNLNNIIEINNLTKQYGSQIAVNNLSITVESGQIYGFLGRNGAG
                     KTTTIRMLLGLIKPTKGNIKIFEKEFESNKTEILKNIGAMVETPGFYSNLTAKENLTIN
                     AKILGIQKENAIEEVLEIVGLASEKVKLFKNYSLGMKQRLGIARALLHNPELLILDEPT
                     NGLDPIGIKEIRKLIKDLAQSRNITILISSHILSEIEQLVDKVGIIHNGVLLEEIMYED
                     LKKKNRQFISISVSDEEKVACLLETNFGIYDYKIKENGEFKIYSHIDRQQEINRLLVLN
                     NIDVFQMRVIEDNLETYFEDLVGGGTIG"
                     /name="ABC transporter ATP-binding protein"
     gene            752..1489
                     /locus_tag="D1E86_RS14765"
                     /old_locus_tag="D1E86_15095"
     CDS             752..1489
                     /locus_tag="D1E86_RS14765"
                     /old_locus_tag="D1E86_15095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000369394.1"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="WP_000369394.1"
                     /translation="MDNLLRTEFIKLKRSYMFLISILGTCVAPFMVVVASFISMRTKVP
                     TPNIVFKQLFEEVSLYHMLIIGPPLYGVIIAYLFGREYIEDTLKNLLIIPISRESFLVS
                     KIILLFLWIQTLSVIAWLLTLMLGMLLHFQGLSQSLIIDSFFTFVIGGVLLWILSPPII
                     ILSIYFKNYVPTIVLTIIITLINLMTANSEHRGLFPWAAVGDISRGTLPNTYPFLLSLI
                     IIIVTSIFSVIILFSYFKKTDIS"
                     /name="ABC transporter permease"
     gene            1503..>1679
                     /locus_tag="D1E86_RS14770"
                     /old_locus_tag="D1E86_15100"
                     /pseudo=""
     CDS             1503..>1679
                     /locus_tag="D1E86_RS14770"
                     /old_locus_tag="D1E86_15100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_499250.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0050380 - undecaprenyl-diphosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016311 - dephosphorylation [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /name="undecaprenyl-diphosphate phosphatase"
     gene            1736..2410
                     /locus_tag="D1E86_RS14775"
                     /old_locus_tag="D1E86_15105"
     CDS             1736..2410
                     /locus_tag="D1E86_RS14775"
                     /old_locus_tag="D1E86_15105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105956.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            <2551..3186
                     /locus_tag="D1E86_RS14780"
                     /old_locus_tag="D1E86_15110"
                     /pseudo=""
     CDS             <2551..3186
                     /locus_tag="D1E86_RS14780"
                     /old_locus_tag="D1E86_15110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009251744.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /name="aminoglycoside 6-adenylyltransferase"
     gene            3183..3713
                     /gene="sat4"
                     /locus_tag="D1E86_RS14785"
                     /old_locus_tag="D1E86_15115"
     ARG             3184..3710
                     /name="sat4"
                     /gene="sat4"
                     /gene_name="streptothricin N-acetyltransferase Sat4"
                     /tool="amrfinderplus"
                     /drug_class="STREPTOTHRICIN"
                     /identity="97.78"
                     /coverage="100.0"
     gene            3806..4600
                     /gene="aph(3')-IIIa"
                     /locus_tag="D1E86_RS14790"
                     /old_locus_tag="D1E86_15120"
     ARG             3807..4597
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            4876..5447
                     /locus_tag="D1E86_RS14800"
                     /old_locus_tag="D1E86_15130"
                     /pseudo=""
     CDS             4876..5447
                     /locus_tag="D1E86_RS14800"
                     /old_locus_tag="D1E86_15130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001079940.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /name="HTH domain-containing protein"
     gene            complement(5616..6290)
                     /locus_tag="D1E86_RS14810"
                     /old_locus_tag="D1E86_15140"
     CDS             complement(5616..6290)
                     /locus_tag="D1E86_RS14810"
                     /old_locus_tag="D1E86_15140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105991.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            6552..6737
                     /locus_tag="D1E86_RS15025"
     CDS             6552..6737
                     /locus_tag="D1E86_RS15025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001037130.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            complement(6960..7538)
                     /locus_tag="D1E86_RS14815"
                     /old_locus_tag="D1E86_15145"
     CDS             complement(6960..7538)
                     /locus_tag="D1E86_RS14815"
                     /old_locus_tag="D1E86_15145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690637.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(7802..8182)
                     /gene="blaI"
                     /locus_tag="D1E86_RS14820"
                     /old_locus_tag="D1E86_15150"
     ARG             complement(7806..8182)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.41"
                     /coverage="100.0"
     gene            complement(8172..9929)
                     /gene="blaR1"
                     /locus_tag="D1E86_RS14825"
                     /old_locus_tag="D1E86_15155"
     ARG             complement(8176..9929)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.38"
                     /coverage="100.0"
     gene            10036..10881
                     /gene="blaZ"
                     /locus_tag="D1E86_RS14830"
                     /old_locus_tag="D1E86_15160"
     ARG             10037..10878
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(11407..11826)
                     /locus_tag="D1E86_RS14840"
                     /old_locus_tag="D1E86_15170"
     CDS             complement(11407..11826)
                     /locus_tag="D1E86_RS14840"
                     /old_locus_tag="D1E86_15170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418034.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_000418035.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            11950..12921
                     /locus_tag="D1E86_RS14845"
                     /old_locus_tag="D1E86_15175"
     CDS             11950..12921
                     /locus_tag="D1E86_RS14845"
                     /old_locus_tag="D1E86_15175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="WP_000481279.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(13093..13185)
                     /locus_tag="D1E86_RS14850"
                     /old_locus_tag="D1E86_15180"
     CDS             complement(13093..13185)
                     /locus_tag="D1E86_RS14850"
                     /old_locus_tag="D1E86_15180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001791613.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(13342..13689)
                     /locus_tag="D1E86_RS14855"
                     /old_locus_tag="D1E86_15185"
     CDS             complement(13342..13689)
                     /locus_tag="D1E86_RS14855"
                     /old_locus_tag="D1E86_15185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000119690.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(13708..14325)
                     /gene="cadD"
                     /locus_tag="D1E86_RS14860"
                     /old_locus_tag="D1E86_15190"
     ARG             complement(13712..14325)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(15441..15635)
                     /locus_tag="D1E86_RS14870"
                     /old_locus_tag="D1E86_15195"
     CDS             complement(15441..15635)
                     /locus_tag="D1E86_RS14870"
                     /old_locus_tag="D1E86_15195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001004925.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            15745..16437
                     /locus_tag="D1E86_RS14875"
                     /old_locus_tag="D1E86_15200"
     CDS             15745..16437
                     /locus_tag="D1E86_RS14875"
                     /old_locus_tag="D1E86_15200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative immunity/bacteriocin fusion bifunctional
                     protein"
                     /protein_id="WP_000691527.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="putative immunity/bacteriocin fusion bifunctional
                     protein"
     gene            complement(16605..16754)
                     /locus_tag="D1E86_RS15030"
     CDS             complement(16605..16754)
                     /locus_tag="D1E86_RS15030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000695366.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(17301..>17590)
                     /locus_tag="D1E86_RS14880"
                     /old_locus_tag="D1E86_15205"
                     /pseudo=""
     CDS             complement(17301..>17590)
                     /locus_tag="D1E86_RS14880"
                     /old_locus_tag="D1E86_15205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009384749.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(17610..18593)
                     /locus_tag="D1E86_RS14885"
                     /old_locus_tag="D1E86_15210"
     CDS             complement(17610..18593)
                     /locus_tag="D1E86_RS14885"
                     /old_locus_tag="D1E86_15210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_001181105.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFDFRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            19019..19762
                     /locus_tag="D1E86_RS14890"
                     /old_locus_tag="D1E86_15215"
     CDS             19019..19762
                     /locus_tag="D1E86_RS14890"
                     /old_locus_tag="D1E86_15215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_000843732.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(19989..20174)
                     /locus_tag="D1E86_RS14895"
                     /old_locus_tag="D1E86_15220"
     CDS             complement(19989..20174)
                     /locus_tag="D1E86_RS14895"
                     /old_locus_tag="D1E86_15220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276570.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000797248.1"
                     /translation="MKNRIREYRKQKGISQETLSKELKVSRQTINAIENNKYDPTLTLA
                     FKLARLFDTTVDELFS"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(20179..20517)
                     /locus_tag="D1E86_RS14900"
                     /old_locus_tag="D1E86_15225"
     CDS             complement(20179..20517)
                     /locus_tag="D1E86_RS14900"
                     /old_locus_tag="D1E86_15225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001049146.1"
                     /translation="MNLIPFIIILIFSCLWTAITNKYLPSETLDKKGQQDRYDERQRKM
                     FIEILAKSFIWIVYCMLFTLVLKFTGLSPSIEGSWFSQYPEIFFIIVALFLMLFNYYTT
                     NKKYTSKG"
                     /name="hypothetical protein"
     gene            complement(20763..21371)
                     /locus_tag="D1E86_RS14905"
                     /old_locus_tag="D1E86_15230"
     CDS             complement(20763..21371)
                     /locus_tag="D1E86_RS14905"
                     /old_locus_tag="D1E86_15230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000583528.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTFGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKDVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGKAISKIAKEVNITRQTVYRIKHDKGLS"
                     /name="recombinase family protein"
     gene            complement(21857..22756)
                     /locus_tag="D1E86_RS14910"
                     /old_locus_tag="D1E86_15235"
     CDS             complement(21857..22756)
                     /locus_tag="D1E86_RS14910"
                     /old_locus_tag="D1E86_15235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000196697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mph(C) family macrolide 2'-phosphotransferase"
                     /protein_id="WP_000196697.1"
                     /translation="MTRHNEIIKCAEKYQLHIQPQTISLNESGLDFQVAFGKDKHGVEW
                     VLRLPRRPDVYKRTKPEKQTVDFLQKNVSFEIPKWKVHAKDLIAYPKLTGKPAATIDPE
                     IQNYVWEIEHKPLPENFINTLAETLVDLHNIPEENINVQHINIKTIQEIKNDFQRRMNK
                     VKETYGVSDELWNRWKQWLENDELWPRHATMIHGDLHPGHIMVDNQANVTGLIDWTEAT
                     HSDPSMDFIGHHRVFDDEGLEQLITAYGKAGGEIWPRMKEHIIELNAVFPMFIAEFAME
                     SGESAYETMALKELGMKE"
                     /name="Mph(C) family macrolide 2'-phosphotransferase"
     gene            complement(22855..24321)
                     /gene="msr(A)"
                     /locus_tag="D1E86_RS14915"
                     /old_locus_tag="D1E86_15240"
     ARG             complement(22859..24321)
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            24795..25469
                     /locus_tag="D1E86_RS14920"
                     /old_locus_tag="D1E86_15245"
     CDS             24795..25469
                     /locus_tag="D1E86_RS14920"
                     /old_locus_tag="D1E86_15245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WP_001105960.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            <25527..25904
                     /locus_tag="D1E86_RS14925"
                     /old_locus_tag="D1E86_15250"
                     /pseudo=""
     CDS             <25527..25904
                     /locus_tag="D1E86_RS14925"
                     /old_locus_tag="D1E86_15250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019834602.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]; GO:0006355 - regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /name="response regulator transcription factor"
     gene            25901..26782
                     /locus_tag="D1E86_RS14930"
                     /old_locus_tag="D1E86_15255"
                     /pseudo=""
     CDS             25901..26782
                     /locus_tag="D1E86_RS14930"
                     /old_locus_tag="D1E86_15255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015581923.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0000155 - phosphorelay sensor kinase activity [Evidence
                     IEA]; GO:0004673 - protein histidine kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /name="sensor histidine kinase"
     ARG             complement(21861..22756)
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(22856..24321)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             complement(21858..22756)
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             3196..3713
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="97.16"
                     /coverage="95.56"
     ARG             2588..2889
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.0"
                     /coverage="36.23"
     ARG             10037..10881
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     Typing          complement(17098..17245)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          complement(17304..17479)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="92.697"
                     /coverage="94.0"
                     /evalue="1.04e-65"
     Typing          complement(17611..18593)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.187"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          19020..19762
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aaacctacga aaggtaatat taaaatattt gaaaaagagt tcgaaagtaa taaaactgaa
       61 attttaaaaa atattggtgc tatggttgaa acgccaggtt tttatagtaa tttgacagct
      121 aaagagaact taactataaa tgctaaaata ttaggtatac aaaaagaaaa tgcaattgaa
      181 gaagtgttag aaatagtagg actagcttct gaaaaagtaa aattgtttaa aaattattct
      241 ttaggtatga agcaacgttt agggattgcg agagctttat tgcacaatcc cgaattattg
      301 atacttgatg agccgacgaa tggattagat cctattggca taaaagaaat tagaaagttg
      361 attaaggatc tggctcaatc tagaaatata accattttaa tttcaagtca tatattgtca
      421 gaaatagagc agttagtaga caaggtgggt attattcata acggagtttt gttagaagaa
      481 attatgtatg aagatttaaa aaaaaagaac agacaattta taagtatatc agtatcagat
      541 gaagaaaaag ttgcatgttt gttggaaact aacttcggaa tttatgacta taaaattaaa
      601 gaaaatggcg aatttaaaat ttattcacat attgatagac aacaagaaat taatagatta
      661 ttagtattaa acaatattga tgttttccag atgagagtga tagaagataa tctagaaact
      721 tatttcgaag acttagtagg aggtggcaca attggataat ctactccgta cagaatttat
      781 taagttaaaa agatcatata tgtttctaat aagtatttta ggtacatgcg tagcaccttt
      841 tatggtggtt gtagcttctt ttattagtat gcggacgaaa gtaccgactc ctaatattgt
      901 atttaaacag ttatttgaag aagtcagttt atatcatatg ctaattattg gacctcctct
      961 atatggggtt ataatagcct atttgtttgg aagagaatat atagaagata ctttaaaaaa
     1021 cttattaatt atacctatat ctagagaaag ttttttagta agtaaaataa tattattatt
     1081 cttgtggatt caaacactat ctgttattgc atggttgcta actttaatgc taggtatgct
     1141 attgcatttt caagggttaa gccagagttt aataattgat tcattcttta catttgttat
     1201 tggcggagtg ttattatgga tattatctcc accaataatt attttgtcga tatattttaa
     1261 aaattatgtt cccacaattg ttttaaccat aataattact ttgataaatt taatgactgc
     1321 taattctgaa catagaggat tatttccttg ggctgcagtt ggagacatat ctagaggaac
     1381 attacctaat acttatccat ttctattatc tttaattatc ataattgtta catctatatt
     1441 cagtgtaatt atattattct catactttaa aaaaactgat ataagttaaa aggaggagaa
     1501 aaatgggttt tatagagcag attaaagcat ttattttagg tgtagttgaa gggttgacag
     1561 aatttgctcc agtatcatca acaggtcata tgattattgt tgatgatatg tggttaaaca
     1621 ctgctgacga tttaggaagt gcgtctgcaa ctacttttaa ggtggtaata cagttaggag
     1681 gttctgttgc aaagttgaat ttataatata attttaacaa aaaggagtct tctgtatgaa
     1741 ctatttcaga tataaacaat ttaacaagga tgttatcact gtagccgttg gctactatct
     1801 aagatatgca ttgagctatc gtgatatatc tgaaatatta agagaacgtg gtgtaaacgt
     1861 tcatcattca acgatctacc gttgggttca agaatatgcc ccaattttat atcaaatttg
     1921 gaagaaaaag cataaaaaag cttattacaa atggcgtatt gatgagacgt atatcaaaat
     1981 aaaaggaaaa tggagctatt tatatcgtgc cattgataca gagggacata cattagatat
     2041 ttggttgcgt aagcaacgag ataatcattc agcatatgcg tttatcaaac gtctcattaa
     2101 acaatttggt aaacctcaaa aggtaattac agatcaggca ccttcaacga aggtagcaat
     2161 ggttaaagta attaaagctt ttaaacttaa acctgactgc cattgtacat cgaaatatct
     2221 gaataacctc attgagcaag atcaccgtca tattaaagta agaaagacaa ggtatcaaag
     2281 tatcaataca gcaaagaata ctttaaaagg tattgagtgt atttacgctc tatataaaaa
     2341 gaaccgcagg tctcttcaga tctacggatt ttcgccatgc cacgaaatta gcatcatgct
     2401 agcaagttaa acgaacactg acatgatata ttagtgatta gctatatttt ttactttgca
     2461 acagaaccat catttttatt aaaatactct tttgtaaaat ctttctgctc ttcaatgtat
     2521 ttaatttctt tacctctaaa tctattatag ctatttgatg attacaataa aattgatctt
     2581 accttattgc ccttggaaga gttagataat tacctaaagg gcgataaatt aataaaggtt
     2641 ctaattgata aagattgtag aattaaaagg gacatagttc cgactgatat agattatcat
     2701 gtaagaaagc caagcgcaag ggagtatgat gattgctgca atgaattttg gaatgtaaca
     2761 ccttatgtta ttaaaggatt gtgccgtaag gaaattttat ttgctattga tcattttaat
     2821 cagattgttc gccatgagct gctgagaatg atatcatgga aggtcggcat cgaaacaggc
     2881 tttaaatgaa gtgtaggcaa gaactataag tttattgaaa ggtatatatc cgaggatttg
     2941 tgggagaaac ttttgtccac ctaccggatg gattcctatg aaaacatatg ggaagcatta
     3001 tttctatgcc atcaattgtt cagggcggta tccggtgagg tggcggaaag gcttcattat
     3061 gcctatccgg agtatgatag gaatataaca aaatatacca gggacatgta taaaaaatac
     3121 actggtaaaa ccggctgcct ggatagcaca tatgccgctg atatagaaga gaggcgggaa
     3181 cagtgattac agaaatgaaa gcagggcacc tgaaagatat cgataaaccc agcgaaccat
     3241 ttgaggtgat aggtaagatt ataccgaggt atgaaaacga gaattggacc tttacagaat
     3301 tactctatga agcgccatat ttaaaaagct accaagacga agaggatgaa gaggatgagg
     3361 aggcagattg ccttgaatat attgacaata ctgataagat aatatatctt tactaccaag
     3421 acgataaatg cgtcggaaaa gttaaactgc gaaaaaattg gaaccggtac gcttatatag
     3481 aagatatcgc cgtatgtaag gatttcaggg ggcaaggcat aggcagcgcg cttatcaata
     3541 tatctataga atgggcaaag cataaaaact tgcatggact aatgcttgaa acccaggaca
     3601 ataaccttat agcttgtaaa ttctatcata attgtggttt caaaatcggc tccgtcgata
     3661 ctatgttata cgccaacttt gaaaaagctg ttttctggta tttaaggttt tagaatgcaa
     3721 ggaacagtga attggagttc gtcttgttat aattagcttc ttggggtatc tttaaatact
     3781 gtagaaaaga ggaaggaaat aataaatggc taaaatgaga atatcaccgg aattgaaaaa
     3841 actgatcgaa aaataccgct gcgtaaaaga tacggaagga atgtctcctg ctaaggtata
     3901 taagctggtg ggagaaaatg aaaacctata tttaaaaatg acggacagcc ggtataaagg
     3961 gaccacctat gatgtggaac gggaaaagga catgatgcta tggctggaag gaaagctgcc
     4021 tgttccaaag gtcctgcact ttgaacggca tgatggctgg agcaatctgc tcatgagtga
     4081 ggccgatggc gtcctttgct cggaagagta tgaagatgaa caaagccctg aaaagattat
     4141 cgagctgtat gcggagtgca tcaggctctt tcactccatc gacatatcgg attgtcccta
     4201 tacgaatagc ttagacagcc gcttagccga attggattac ttactgaata acgatctggc
     4261 cgatgtggat tgcgaaaact gggaagaaga cactccattt aaagatccgc gcgagctgta
     4321 tgatttttta aagacggaaa agcccgaaga ggaacttgtc ttttcccacg gcgacctggg
     4381 agacagcaac atctttgtga aagatggcaa agtaagtggc tttattgatc ttgggagaag
     4441 cggcagggcg gacaagtggt atgacattgc cttctgcgtc cggtcgatca gggaggatat
     4501 cggggaagaa cagtatgtcg agctattttt tgacttactg gggatcaagc ctgattggga
     4561 gaaaataaaa tattatattt tactggatga attgttttag tacctagatt tagatgtcta
     4621 aaaagcttta actacaagct ttttagacat ctaatctttt ctgaagtaca tccgcaactg
     4681 tccatactct gatgttttat atcttttcta aaagttcgct agatagagtt ctatattaga
     4741 gatgtaaaga gttttggtga agaggtttgt gagtatggct tttataacca gggtgcaatg
     4801 agaagcacta acagcagcta gcttaagaac gcataggata tactttttat ggaagtcaca
     4861 gaggaggaat aaaatttgaa caggattaac agagtaacct ctattcttat tcagctgcaa
     4921 tcaaaaaaat aattcctgcc aaagaaattg cacagcgatt taatataagc ttaaggacag
     4981 tttacagaga tatccggaca cttgaagaag ccggaatacc aattggatct gaggccggaa
     5041 aaggatattt tcttgtagag ggcttcctac ttctgccggt aatgtttaca gcggcggaag
     5101 tgggtgcatt gattacagca gggaaatttt taaattgcca tggagatgaa tcatttataa
     5161 aggattttga ttcagctatg tataaaatca aatctatttt gaagcatggt gaaaaaaact
     5221 atgcacagga gttggagaac agtattaacg tgtacagcac atctggacag aaaaatacat
     5281 tggcggataa cgttattgca gcaattcaga ctgcaatctg caataaaagg gtaatatcaa
     5341 ttcaatatcc tgcatcagga gggcaagaac cggaaagcag aatgatagag cctatatcac
     5401 tggggtttta tgaacagaac tggtacttaa tcggttttgc aggctaagaa atgaatatag
     5461 gaattttcgt gtggatcgga ttaaaagcat ttgcatagaa gaagagctct gtcaaagcca
     5521 tgatggctct ttggaacaaa tattaaaaca aatgctggtt ctgttgcaaa gtaaaaaaat
     5581 atagctaacc actaatttat catgtcagtg ttcgcttaac ttgctagcat gatgctaatt
     5641 tcgtggcatg gcgaaaatcc gtagatctga agagacctgc ggttcttttt atatagagcg
     5701 taaatacact caataccttt taaagtattc tttgctgtat tgatactttg ataccttgtc
     5761 tttcttactt taatatgacg gtgatcttgc tcaatgaggt tattcagata tttcgatgta
     5821 caatggcagt caggtttaag tttaaaagct ttaattactt taaccattgc taccttcgtt
     5881 gaaggtgcct gatctgtaat taccttttga ggtttaccaa attgtttaat gagacgtttg
     5941 ataaacgcat atgctgaatg attatctcgt tgcttacgca accaaatatc taatgtatgt
     6001 ccctctgcat caatggcacg atataaatag ctccattttc cttttatttt gatgtacgtc
     6061 tcatcaatac gccatttgta ataagctttt ttatgctttt tcttccaaat ttgatataaa
     6121 attggggcat attcttgaac ccaacggtag accgttgaat gatgaacgtt tacaccacgt
     6181 tcccttaata tttcagatat atcacgataa ctcaatgcat atcttagata gtagccaaca
     6241 gctacagtga taacatcctt gttaaattgt ttatatctga aatagttcat acagaagact
     6301 cctttttgtt aaaattatac tataaattca actttgcaac agaacctcat ttactatatg
     6361 ggcatctctt tcattattaa tacaaagctt tgtatctccg atattaggca aaggtgtaaa
     6421 cgaattaggt gatactatag gattcaacat tatattaatc gtttctttaa taatgattat
     6481 cttcttattt tttataaatc gtagtaaaaa tatctcctat gattatataa aagttcaaag
     6541 aggtgaagcc aatgaataaa ttagaaaaat ggtctttggt atttattatt tttacatttc
     6601 tctcttcatt agcactttta tatttcaaat ataattttag ttcggttatg ccagtcctaa
     6661 gtctttctat tttaactata ctaatattgt tgacgagtat tattactgta gtttcagtta
     6721 atgatgaaga tacttaaaac gttcattagt gaaacaggta ttatattaaa aaagcgtacg
     6781 aatttgtacg cttttttctt gtgttattat taaaatctca taacaggaaa atattatgag
     6841 attttagacg ctgtcagaac gtctctttta catcgagtga cattgaatca aagtctttgt
     6901 atgttaatga tatataaaat tatttagtag attcattata gtaagctaga ttagttgctc
     6961 tacttgtttt tattctcttt tgcctctaat ttattgagat aacgataaat agttgtacgt
     7021 gaaacttgcc actgctctgc aattgtttta attggcgtac cattatcata aagtgtctta
     7081 agtaagttta aatcttgttt atttaatttt tcaggtctac ctccatatcg gcctctagca
     7141 cgtgctgcaa ttcgaccggc tgatgatcgc tctaaaatta aattacgttc aaactctgca
     7201 aatgctgcga ataaatgaaa taataattgt cctgtagaac ttgatttatc catcgttata
     7261 ttttcttcta aactatgaaa actcacacct cgttcgttaa gttcattaac taacgtgatt
     7321 aaatcctcca tgttccgtcc tagtctatct aatctccaaa caacaatcgt atctcctgac
     7381 ctcgcaaatt caattgcttt atctaaacca ggtcgcttac tttttgaacc actcatatgg
     7441 tcattaaata tcttttcaca accatatgta tttaatcgat cctcctgtaa attcaaattt
     7501 tgtaatccag ttgaaactct tgcataacct attttcaaaa tacagacctc ctatatacac
     7561 ctttagtgta ccataacttg attacgaggt cttttgtgaa catagatttt ttgttgggtt
     7621 tttgaacaca taattctatg taatacttac ttatttagac aaaaaacaag agtgtacaga
     7681 aaatggttat tttctggaca ctctcatctt taataatata ttttaaatgt cattaacaaa
     7741 actaatttaa taagagtcaa gtatggttta catatgtatt atgtttgaaa catacctcta
     7801 attacttttt actaatatca tttaaaatgt ctcgcaattc ttcaatttct ttgttattta
     7861 attcttcatt tttcgcaaaa ttcagcacta aacttttcat atcccctcca tacagtttat
     7921 taagaaaggt tttagcagtt ttcattttaa tatcgtcttc tttaatattt gatgagtaaa
     7981 aataaatatt ttctgatttg tatcgtttta taatctcttt tttatatagt cttgtgatta
     8041 atgttctaat cgttttatca ctaacttctt tatatttttg aatttcaact acaatttcat
     8101 tagctgatac tgatttttta tcccatatta tattcataac atcccattca gccatagata
     8161 tttcaacttg cttattggtc atttaaaaca cccattcctt ttaatatttt ttcacttatt
     8221 aattcagcat ttttcccaga cgggtttcca tctgataaat gtgtagcaaa ataatactta
     8281 tcatgatttg taattacgta acctacaaac cacccattat tatacttccc gtttactata
     8341 cctgtacctg ttttcccata cagttcatac ttttcatttt tcttaatcaa taatgaagaa
     8401 gataattgat tctttgcttt tttactaaaa tggttatttt gttccatcat atttttaaaa
     8461 actattactt gttcaagatt agatattttc aaactatctt ccatccaata gcttttataa
     8521 cttcccaaat tttcattacc ataatttaat tgcttgagtt gagccgcagt atagttcttt
     8581 ggtatttgat tactaatacg ttcgaagtac caattaactg aattttgcat tgctgtattt
     8641 aaatcttgtt ccttattcca agactcgaaa agataatgtt tatgattcca tgacatacgt
     8701 gaatttttat cacttataat atgacggtca agtccaaaca gtgctaaata aattttgtaa
     8761 gttgaatcag gagaatatct ttttctactt tctttttcat tataaatata gtatttgtct
     8821 ttcttcatgc tgtacataac gaaagatcca ctatttgaac caaaattttt actttcatct
     8881 aaaatttggt aatcgctttg taagggcttt ttataattat aatcagttaa ggattgcccc
     8941 attaaaaact ggctttgaat tatcatgata aaaaaagtaa aaatacaaat aaaaattaga
     9001 attaattttg actgcttttt cagatcggct tcttttatat taattaatct acttttgagt
     9061 aatgattttt taccattaaa tgaatggctt aatatatttt tgttggaaaa cggggttttt
     9121 aatacggagt ccataataga ttccgcataa gttttaaatt catttttgtt aatattatta
     9181 aggacaaatc tatcggcttc tacttcattg tcatgaatta tctttctttt tacaatatgt
     9241 actaatggat tgtaactcat aataatagag aagatattaa agataattaa atgtaaagta
     9301 tctctatttt tagcatgagc atattcatgc agtattatat attttagtct tttatcaatt
     9361 acacttttaa aatatgaact aggaatcaaa ataatatatt tcccatacca aaaagttatt
     9421 ggagattgaa tagcctctgc ttttcgaatc acaatatttt ttttatattg atggttgaaa
     9481 agtatcgtat ctattttatt tttttcattt tcgtttagat aaagtgactg tttctttaaa
     9541 tatttaagat ataataaggc tttcaaaaat ttaaaactta aaataataac taaaactatc
     9601 caaataactg tgcagatatt atcaattgaa tcccaattaa acttatggat atctgttgtg
     9661 aactcttgaa taggtttggt ggtatttatg ttatggttca aatcgtgtga cttactttca
     9721 actgtgggcg cttgattatt cacattatta aattttataa aagagaattt aattgggata
     9781 aaaggaatta atccagcaag catagttaga taccaaactt tataatttaa actataatta
     9841 aaatagcgtt ttaatatgta cctaaaaaat actaacaata gaaatataaa acaaaagctt
     9901 actacgctca ttattagtaa tttagccatt ttgacacctt ctttcaaata tttataataa
     9961 acaattgaca tcaatattac aattgtaata ttattgattt ataaaaatta caactgtaat
    10021 atcggagggt ttattttgaa aaagttaata tttttaattg taattgcttt agttttaagt
    10081 gcatgtaatt caaacagttc acatgccaaa gagttaaatg atttagaaaa aaaatataat
    10141 gctcatattg gtgtttatgc tttaaatact aaaagtggta aggaagtaaa atttaattca
    10201 gataagagat ttgcctatgc ttcgacttca aaagcgataa atagtgctat tttgttagaa
    10261 caagtacctt ataataagtt aaataaaaaa gtacatatta acaaagatga tatagttgct
    10321 tattctccta ttttagaaaa atatgtagga aaagatatca ctttaaaaga acttattgag
    10381 gcttcaatga catatagtga taatacagca aacaataaaa ttataaaaga aatcggtgga
    10441 atcaaaaaag ttaaacaacg tctaaaagaa ctaggagata aagtaacaaa tccagttaga
    10501 tatgagatag aattaaatta ctattcacca aagagcaaaa aagatacttc aacgcctgct
    10561 gctttcggca agactttaaa taaacttatc gcaaatggaa aattaagcaa aaaaaataaa
    10621 aatttcttac ttgatttaat gtttaataat aaaaacggag acactttaat taaagatggt
    10681 gttccaaaag actataaggt tgctgataaa agtggtcaag caataacata tgcttctaga
    10741 aatgatgttg cttttgttta tcctaagggc caatctgaac ctattgtttt agtcattttt
    10801 acgaataaag acaataaaag tgataagcca aatgataagt tgataagtga aaccgccaag
    10861 agtgtaatga aggaatttta atattctaaa tgcataataa atactgataa catcttatag
    10921 tttgtattat attttgtatt atcgttgaca tgtataattt tgatatcaaa aactgatttt
    10981 ccctttatta ttttcgagat ttattttctt aattctcttt aacaaactag aaatattgta
    11041 tatacaaaaa atcataaata atagatgaat agtttaatta taggtgttca tcaatcgaaa
    11101 aagcaacgta tcttatttaa agtgcgttgc ttttttctca tttataaggt taaataattc
    11161 tcatatatca agcaaagtga caatagcatt ttacaagtat tttttattgt tcgattaggg
    11221 taaacctaaa taatacataa attatattac aatatgttta ttatagaggc taaagtatct
    11281 tagaaatttg gatagtaggt ttttcgggaa taaaagtata gttggcttta atatataatt
    11341 aagctaagct atcatttata tttactcgat tataattcgc acttcaactt ttttataacg
    11401 taaaaattaa aacgtagttt tatttatctt tagtaatatc tttttaaaca ctacagtttc
    11461 ttcattagtt aaattagcga agtaatgatt attaagttga taggctttct tttctaatgt
    11521 tggccataag tcttttgctt tatttgtact gtttattagc acagttcttc tattttcatt
    11581 atcagtttga cgtgttatta gatccttttt ggacatctta tctaatattc cagatattgt
    11641 tgaaggttct aaatttaaag tattaccaat cgctttaggt gtattcaaat tactattaat
    11701 caagcaattc aaaacaccat attctgctgg agtaatatta tagggactta ataaactttt
    11761 aaaatgttta aaaactctat tctgagaagt actcaacaaa taatttatac aattatctaa
    11821 ttccacaact aaaacctctc ttaaatcatt agtattgact cgcttatcat atcatgataa
    11881 gttttgtagg aaaatagttt tgcaacaaaa acatacttct acaaaacaat tgtgaaagaa
    11941 ggctaataaa tgttcaatgc ggtagtagtg agaaaaagtg catcaaatgt tagttataaa
    12001 gtagaaaaag ttgatgaatc tcatttatcg aagggtgatg tattagtaaa agtggtatac
    12061 tcttcaataa attataagga tatgctagct ttacaatata aaggcggtgt aattagagat
    12121 tatcctatga ttcctggtat agattttgca ggtattgttg aatcaagttc gaatgataag
    12181 tttaaagaag gcgataatgt attagttact ggttatgatg ttggcgtgac acatacaggt
    12241 ggattttcag aatatgcaca agtgcctgga gagtggattg ttcctattcc ccaagaaatg
    12301 tctattaaag agtctatggt atatggcaca gccggtttta cggcagcatt atcaattttt
    12361 gaactagaaa aatatggaat gaatatcaaa tcacaacctg aaattttagt gtctggggct
    12421 acaggtggtg tgggcagtgt tgctatacaa attttacata aaattggata tgaaaatatc
    12481 actgctatcg taagaaaaga aaagcaaata gaaatcgcaa aaaaattagg tgcaaaacaa
    12541 gtaataataa ttgaagatga taataaaccg cttaaaaaag gtatttttga ttatttctta
    12601 gatacagtgg ggagtaatgt aacattatac ggtttaaaac gtctaaatta tcaaggtgtt
    12661 gctactgtat gtggaaatgt agcaggaaat tcacttaacg ctaatatatt accgtttatt
    12721 cttagaggta ttaaattaat tggcattgat tctgtatatg ttgatcataa tatccgtgaa
    12781 gatatatgga gtaagttagc aaatgaatgg aatataggaa attcacttct atacaatgaa
    12841 attggatttg aagaattcta taaaacgata gatcagcttt taaaaggaca acatttagga
    12901 agaactattt taaaagtata agtgtgagta ttcattaata catttactat taattcaatc
    12961 attttgcatt tctctactaa ccagtgttat aatttatata acgaaaatga ttaacaatta
    13021 atgcaccaat ccccacacta ttgcagtagt gtggggattt tttcgatgct ggcttataaa
    13081 gtcgcctatt aattatttgt tgcgtttact aagccaataa gtataatacg caacagcaca
    13141 gccactgatg actggtgcta tgatgtgaac gaaaatgatt agcaaagtaa tgcacctcct
    13201 ctcttcgtca attgacgcct gagagatagg cgactctatt attataccat ctgtgaatat
    13261 acaagcatat ctacttccga taagtcgtct tatgttatat aactttgttt tttatagtat
    13321 caagacaaga agaaactcgt ttcaaaaacc ctcatgattt ttagagaaaa actctcttat
    13381 ttcatcgtct ttaataaaat aatatgccat ctttccatct ttataaaaat caagtacctc
    13441 atttttatat aaaagcctta aatgatgtga agttgaagca acactcattt tcaatatcaa
    13501 agaaatatca caaacacaca actcatcttc tttaatcaaa gataatatga ttttcaattt
    13561 cttctcatca caaatttttt ctaaaatgtt aagtaatttc ttagatttat catcttctaa
    13621 aaaacttaaa gcattgttaa ctttatcctc atgtacacag atcacatcac aagtattttc
    13681 ataactcata taaaatcaca ccctaaatta aaatataaat cctaaaattg tttgaatagt
    13741 gtcattttca ataataataa ataaacctaa agctatataa ataatagcca taatccaacg
    13801 actaaatttc tcaacaattt ctccaattcc tggaatatta gctaattttt gtgcagtaaa
    13861 caccaagaag aaaattaaaa ttaaaaagac aaacagagta agtaataaat tagtaacact
    13921 taatgtcaca aaatacggaa caaataaacc aatattatcg gcgccacaac ttgctatcgt
    13981 aacaattgca accgtaccaa ctaatttaga caatcctttt tcattcaatt cttttttagc
    14041 tctcttttct ccttcacaat catcataaat agccacttta attccaagat aaattggtat
    14101 taaacccaat aaacctaata tccacttttc tggaacataa tttaatacaa aagctaaaaa
    14161 caaactaact aatattaaaa taatagaccc taaatattga ccaacataaa tatctctata
    14221 ttcttttcta gtctttgctc tagcaaaaaa tattaataaa attactaata aatcaactgc
    14281 tgtagcaata taaagaacag cagcagcaac aaccgtttga atcataatac acctcattca
    14341 aaaatatttt tgaatgtatt ataacttata tttttaaata atcataggtg ctttattcca
    14401 attgctttat tgacgttgag cctcggaacc cttaacaatc ccaaaacttg tcgaatggtc
    14461 ggcttaatag ctcacgctat gccgacattc gtctgcaagt ttagttaagg gttcttctca
    14521 acatcaataa attttttcgg cataaatgcg tgtctatgcg tagacatgga gacacttcag
    14581 aattatggag tgattacatg agtttaacta tttttcttta ttcagtttta ggaagtttat
    14641 tagcaaatta tatctacgaa aaatcttcaa aataaataac tttttcggtt ctactttgta
    14701 cactttatct acctggtaga cctaattgtt attgctttac aggtctaaaa ttcgtcgtta
    14761 taatctagtt aaatcccgta agggcgcact tatacgtcgg ataaatcgac atgtgcaaaa
    14821 acgtaatcga ccttcgtcga tttttttatt tcaaaattaa agaaacggct tgagatattc
    14881 cgagcagtta taaaaattaa tttgcgttga atattgctac tacattcttg aaaaagtgat
    14941 gtagatttat agcccataac ttttttgaat tacatcgacg atacggcgtc gaaagaaaaa
    15001 taaatagacc gtatgaaaga aaaagctacc tcactttatc tggggtagct tttatttttt
    15061 atgcccttat tttgaatttt aagagggcat tttaaagatt taggggtgat tcatatagtt
    15121 ttatatctaa aacttatata tgcttttaaa acgcaaatat gagccaaata aatatatgct
    15181 attttcaaaa acaaaaattt gagcaaaaac aataactatt tttagacact gcccatttac
    15241 atgcaaatta aaaattagca taaaattctt taaaacttcc ccacgttttt ctaaattcct
    15301 gtagggcgtt tttatcaaaa atcaagacaa gaagaaactc gttcacactc gtttcaaaaa
    15361 aacaagaaat ctaatctata cacctaccgt tttccaaccc cctcaaagca tacaaattaa
    15421 aaacaaaatt attcataatc ttactttctt ttaacaaaaa cataaaaacc ataaatagac
    15481 aaattaacta tcaaaggcaa taaacagtat aaaaaaacca cgaataaatc ttcatcaaca
    15541 tctaaaataa aaaagaataa aacaattaac aaaatactaa ttaacaaacc taaaagtggc
    15601 aaacttttta tatatttttc taaattttca ttcataaaat agactccttt caaaaatatg
    15661 tttataaata tattaaaata aatattgatt ttataaagcg cttacttata caattaaaat
    15721 atcttattat cttggaggta tcaaatgaaa attataaaat tattttcaat aatttccttg
    15781 ttcctactgg tatttagcgc gaatttttct aatgcttacg caaatgaaga acaaaaaagt
    15841 tctttactag aaaatcaaaa agaaaaattg aaaagcaaaa acatcgaagt atcacaaatg
    15901 accaagaaag aaataagttt tctagaacaa ttgcaaaata aaaatgaaga tatgcaaaaa
    15961 ttcgaaaagc aaatgaaaaa agaaggattt aaaaaaataa agctagaaga caaaaattct
    16021 aaattaaaat atctagctac agaagcaaat gataaaaatg catatggcta catagctaat
    16081 aacgcttata aaaatgaaaa aacaaaagaa attgtagttt ctgaaacaat atatgataac
    16141 tacaacaaaa aaatcacaaa attcattgcc gaaaaaagaa gtatgactga aaacaaagag
    16201 ggaaaaatac ttattaacaa aaattacgtt gaatataagg ctgaaaaagt tgataaaaac
    16261 agaccggtaa catatgcagg attcaaatgg aacggcaaag cattcgcttg tagtatggct
    16321 ggactttatg catgtgctca ctactgtgga gtatgggcaa tcgtaaatcc aatagccggc
    16381 ggtgtatgtg aagcagtttg cggaactgca tttgcagctg gatgctctgt aggttgattt
    16441 tattccaatt gttttattga cgttgagcct cggaaccctt aacaatccca aaacttgtcg
    16501 aatggtcggc ttaatagctc acgctatgcc gacattcgtc tgcaagttta gttaagggtt
    16561 cttctcaaca tcaataaatt ttttcggcat aaatacgatg ttccttattt atcctcataa
    16621 aaaacaatag ctgaaatata taaccaatta ctgtgtgttt gaatttctaa tacatgaata
    16681 tcattcttta aaaacctatt aacttgttta tctaattgac gatgagtaaa agtagcgaaa
    16741 gttttaatct tcatgatatc tctcctttta taaaaatagc aatccttatt acaatattaa
    16801 acacttttat tttggatttt aagaggcatt ttgaagactt agaggcaaat catataggtt
    16861 ttgtacttaa aaatctatac agtctcttaa aacgcaaata tgagccaaat aaatatatgc
    16921 taatttcaca aacaaaaatt tcagcaaaat cagtgactaa ttttttagat actgcccatt
    16981 tacatgcaaa tttaaaaatt agcataaaat actttaaaac ttccccatgt ttttctaaat
    17041 tcctgcaggg cttttcttat caaaaactta gaaattttaa tttaactcta aaatctccgt
    17101 aagagcataa gggaaatttg ctatcattca aaaatgatag atctggcaag gccagacatt
    17161 ccaagggttt taagttattt taaagtgata tcatacaaag ctgtagtgtc acacttttgt
    17221 gacactacat acagcatttg tcacaaaaat aagacagcac ttttttacag aaaaacaata
    17281 aaaaaagaca tcagttatca ctaatgtctt aaataataat tttgcttttc gaaattccaa
    17341 attgcggtaa ttgaatgtgc tttttttctt cgtctgtcgt tttatcttca tcacttgtat
    17401 taatcaaatt accatcttcg gcatcgtcta agtttaaaat tttatgcttt tgtttaagca
    17461 atccaccata acttaacata cgttttcgat acaaaccttt ttctaaatca cttacaattt
    17521 cttgattttt ttcgtcgtca tcagttaaaa agtcagatga tttaacggaa tattttgatg
    17581 tctcttcgag tgttataaaa tcatttgaat tattgattaa agatattata ttgtttcatg
    17641 tttttacggc gcatataaag ggcatgtgtt tcttcaagtt cagttagaat tgtttgcatt
    17701 aaataagctt gcattgactt gattgtttcc ttttggcctt taactcccct atcatgtata
    17761 gcttttttaa gtctttttaa agaagttaat atttcatcct caatgtcctc taacatgtaa
    17821 tgcatatctt catgccttga attaaatgat ttttttgctt taagaataac agcctttatg
    17881 atttctaaat ctctataatc atattttaat aaataattag ttagttgttc tgggaattct
    17941 tgcaatagca tttctttatc atcaaaatta tgtgtaaatt gatttgaatg atttgaatga
    18001 ttactaattt catttttgta ctttatatca ttcaagtcat tcatatcatt attctcagta
    18061 tcattaaagt caatgtcatt aaagtcagta tcattagtgt tcgattttcg aacttctgga
    18121 cgttcgattt tcgaacttct ggaagttcga aaatcgaact tctggacgtt cgattttcga
    18181 acttccttct cgccgtaagg ttcaacatcg ttttcttctt tttctatttt gtaaatatca
    18241 cgttctgtga caataggttt cattaaatat agaatatttg gtttatttaa accacgtcgt
    18301 ttttgaatga gtagaccatc gttttctaac ccttttttta tttttgttaa cttttctttt
    18361 ttacaattta agatttccat tagcttttca tttgaataaa caaagtaaat gttaccatct
    18421 tcatcaaccc agctattttt aatagataaa tttaagcgat cacgtaagat agcataggct
    18481 attttcatat cattagttag atttttataa ttttcactgg taaagaatac tttagggatt
    18541 tgataaaatc tttctttgta attttcttgc actgtaaaat attgattttg catgacaaaa
    18601 aacctctttc catattttag tttggtaaga ggtaataaaa cgtttttatt tagctttaca
    18661 tttatttaat gatttaggtg cttgcactaa gatattattc attatataat acaagtatcg
    18721 aaaattatat aaataaacag tttctaaacg ttttattacc aaaccccgac tattaccagt
    18781 agttggggtt tttgttatat taagtttatt atagcacttt aaataaactt ataaaaggga
    18841 aaatatagct ttatcaaggg tttataaacc cttgataaat atcataaacc tttcataaac
    18901 ccttgataaa aaggttgatg gatgtttatt tttatttatt aatcacttta ttattaagca
    18961 ttataagctt ataatatttt atcaagggtt tataaacatt ttataaaggg ttgatgatat
    19021 gaaaagtgtg aaaaagttga gtgaagaatt aggggttagt aagcaaacga tttttaataa
    19081 tattaagcga ttgaatatag agacaataaa acaggaaaac acttcgttta ttaaagaaga
    19141 taccgatata gaaaaaatca ttcaaagagt aaatgaaaat aaaaagaaat atggttttga
    19201 aagtactact gaagacaaac aaaaaaaagg gtcggataat attaattttg aatcgaaaag
    19261 cgatgctcaa atagtagaaa tccttaaaaa tcagattgat actttaaata atcaaattga
    19321 aaaacaagaa agtcgtcatg aaacaacaat tgaattttac agaaaagagt tgcaagaaag
    19381 atcaaaattg cttgaaaatc agcaagttct ggcattagag agtaataaaa agattcaaaa
    19441 attagaaaat caattagaaa aagaaaaaca ccttaattat ccctttgata catctactaa
    19501 cactagacaa aacgttgatg cacaagaaaa aacatatact actaatcctg taaatattaa
    19561 cagagatcag gaagaaacta aagaaacaga gattcaatat aaggatatat ctggaagtca
    19621 aagcgacgaa agtacacaag gtgaagaagc aaaaaaagaa gacgttccag ctaatctaaa
    19681 tgacaatgat agtgatatag aagaaaagag tgaagaaacg gaacctaaaa aggggttttg
    19741 gagtcgtttg tttggtagct aaaataattg attaggcact aaaagttata aaattttagt
    19801 gtcttttata tagtgagaac ttctggtaat catcgattat gtaaactaaa gtatttcaaa
    19861 taattaactg tattaatact ctcatcatga ttgcgttata aacgttcgtt attgagacaa
    19921 aatttaatag tactactaca caaaaagaga gtgcgaattc gcactctctt tttgtgataa
    19981 atgaatggtt aagaaaataa ttcatccaca gttgtatcaa acaatcttgc caacttaaat
    20041 gctaatgtca atgtaggatc atatttattg ttttctattg cattaatagt ttgcctagac
    20101 acttttaatt ctttacttaa agtttcttga gaaattcctt tttgttttct atattctcta
    20161 attctatttt tcattaattt aacctttaga tgtatatttt ttatttgtag tatagtaatt
    20221 aaacagcata agaaatagtg ctacaattat aaagaaaatt tctggatatt gagaaaacca
    20281 agatccttca atacttggtg acaaacctgt aaatttaagc actagtgtaa ataacataca
    20341 atatacaatc caaataaaac ttttagccag tatttcaata aacattttac gttgtctttc
    20401 atcgtatcga tcttgttgtc cttttttatc taatgtttct gaaggtaaat atttgttagt
    20461 tatagccgtc cataaacaag aaaaaattaa aataataata aaaggaatta aattcattat
    20521 aacacctcat aaatgtaaaa agtatttgac atttatgagt gtaaatattt ttgatacaaa
    20581 tgtcaaatac tttttacatt ataatatatt ttaaaacacc ttattagtaa aacaattact
    20641 atatagaaag ctgcgaactc gtactctttt ttcttgtata attattaaaa tctcaattca
    20701 ataatatgtt atggaatttg agacactgtg agagacgctc atttgcattg acaatcaatt
    20761 tatcaagata atcccttatc atgtttaatt ctataaactg tttgtcttgt gatattaact
    20821 tctttcgcaa tcttactaat cgctttgcct tcttctaaca tttccaccac gcgatgataa
    20881 ataacacgtt tctgtgggtc tttagcattt ggtgaataaa gtaaagggcg ccctttatat
    20941 acgccttttt ccttcgcaac ttgaatccct tgcgcttgtc gacgtttact ttcatttctc
    21001 tcttgttctg aaaccattgc taatatttga atgattaaat ctttcataaa cttatccagt
    21061 aatggattgc caattacttc attcatcata ggtaagctgg taatcattaa ctgaacgtct
    21121 ttttctttta aataattcac agtttcaata atttcatcat agttacgtcc taaacgatca
    21181 atagattcca caacgaatcg atctcccatt ctgacaaaat tgagtgcttc ttgaaataca
    21241 ggtctatttt ccactgactt tcccgactgt ttctctgtaa agattttctc cacaccaaac
    21301 gtctttaaat tatccaattg tctttctaaa ttttgatcta tcgatgatac tctcgcataa
    21361 cctataatca ttcatcttca ctccataata aatatacacc ctaatcatac gttttaattg
    21421 ttataatttc aacaattctt tttgtatggt tagggtgtac tcaaagtgta catatctata
    21481 attaaaactt actaaaaata aatatagatt ttttctttgt aacagaaccg ttcatttgaa
    21541 ggtcatctct atcataaata tttaaattaa ctaaaaattt taatcatctg tttaatactt
    21601 atgaaatgta tttacggtag gtattaaaat tgatgaaatt tatataagtg ctttcaatga
    21661 aaatgaccgt ttatttatcc tcctgattta aggagttaga aatttcgaaa acgattcttt
    21721 ccatttgttg catttgttcc atgtccagat atttaataca ttatagaaaa ccaaagacca
    21781 tcactaatta aacgcagttt taaaatttca tcaggattgc cttcgtcttt aaaatgggcc
    21841 tcttttaata taagttctac tctttcatac ctaactcttt caatgccatc gtttcatacg
    21901 ccgattctcc tgattccata gcaaactcag cgataaacat tgggaatact gcattgagtt
    21961 ctattatatg ctctttcatt cgtggccata tttcacctcc agctttaccg tatgctgtta
    22021 taagttgctc taatccttcg tcgtcgaata cacgatggtg tcctataaag tccattgatg
    22081 ggtcggagtg ggttgcttca gtccagtcta tgagacctgt gacgtttgct tggttatcta
    22141 ccattatatg tcctggatgt aagtccccat gtatcatggt cgcatgtcga ggccatagtt
    22201 cgtcgttttc taaccattgt ttccatctgt tccataattc atctgatacg ccataagttt
    22261 ctttaacttt attcattctt ctttgaaagt cattttttat ttcttgtatg gttttgatat
    22321 ttatatgctg aacgttaatg ttttcttctg gtatgttgtg taaatctacg agtgtttcag
    22381 ctaatgtgtt aataaagttt tctggtaatg gtttgtgttc aatttcccat acataatttt
    22441 gtatttctgg atctattgtg gctgcgggtt tacctgtaag ttttgggtaa gcaataaggt
    22501 cttttgcatg tactttccac ttcggtattt caaatgaaac attcttctgt aagaagtcta
    22561 ccgtttgttt ttcgggtttt gttcgtttat aaacgtcagg tcttcttggt agtctcaaaa
    22621 cccattctac tccatgttta tcttttccaa atgcaacttg aaaatcaagt cccgattcat
    22681 tcaatgagat tgtttgaggt tggatgtgta attgatattt ttctgcacat ttaataattt
    22741 cattatgtcg agtcatttta ttggatcctt atttctatta tatttttctt gtgaacgtat
    22801 tttttatatt gatataaatg aacctaatat tcaatataaa ttagtgtata gtttttaagt
    22861 tatatcatga agagattgtc ctgttaattc ccatttttta tctgatacat gtttaacaaa
    22921 ccttgtatca tgtgatgtaa acaaaatgat tccaggatat ttattcataa acatttctaa
    22981 tgcttctaat gttttaatat ctaaaaaatt agttggttca tccaaaatta acatattcgc
    23041 tttcgttgaa aataatactg ctaacgataa tttcgttctt tccccaccac tcaaaacatt
    23101 acaagaacga tcaagtgctt catttaaacc caagttattt aaaatagctc tactgaatga
    23161 ttctgatgaa tccgtttcat ccattaaata ttgcaataat gaaacgtcac gcatgtcttc
    23221 ataagcaagt tgacgatagt atgccatttg cactttagga gaacaatcaa ttccctctat
    23281 ttggtggtaa atagcttcaa gtaaagttgt cttacctaca ccatttgcac ctacgagcgc
    23341 tatatttttg ccatatggta tttggaatcg tacttgtgtt agcagttttt gacttccttt
    23401 aaccaatgtt agattttgtg caatgattgg ataattatta tggatatcat aaattttatt
    23461 ttgtgggaaa ttgaattcat gataactttg tggtttttca acttcttcca aatgttccat
    23521 tcttttttca atatgcttag cttgtttttg agcagccttc tcaaccgtgc ctttttgttt
    23581 tgatgcactt aaacgatctg gtgctatact tttgtttttt tgttttgatg atgcttgtgc
    23641 catttgttgc gcttgatttc gtttagcttt actggcttgg gacaatcttt gtttttcact
    23701 tatatactgt tcatattgac gttgttgttc taactgttct tgttcatatt gattttgata
    23761 ctgtgtgtaa ttacctttaa acactcttat tgtgccatct tcttgtatat cccaaattgt
    23821 gtcagcaatt tggtctataa gtgctctatc atgacttact ataattaaag taccatagta
    23881 atattttaaa atatttttca gataatcttt accaatttta tccaagtgat ttgtaggttc
    23941 atctaaaagt aatatcggac tataatttga tatgacatta gctaatttat attttgcttt
    24001 ttcaccacca ctcatactgt cggttgtatg cataggtata tggagttcac tcattaaact
    24061 accgtctaac gtgttaaaat cattttccac atccatgtta agctgttcaa aatattgaat
    24121 ttcgccaacc gtttcaactg ttccagattc tggttttgtt ttttgagcaa tcatatttag
    24181 taatgtggtt ttgccagtac cattaccccc aataagtgct attttttcaa attggtaagc
    24241 gtaaagatga ccgatgttaa gtgatcgtaa atctgtcaat ttatgattga tttggttaaa
    24301 tttaattgta tattgttcca tatttataca ctccttgtat atttaaagga cgtgtacgca
    24361 aaaaaatgag acaggctact cccgtctcat tcacattaca ctttcaaaca cttaaaaatt
    24421 tattatgatg ttttagtatt tgaaagcgtt tattattcct atcgaaggat aaaaaatgac
    24481 ataagtcatc ctatgagtgt gtattgcgga caagcctttt tgaattaatt tagttttgta
    24541 ttcaaaaagg tttatttgag tctcatagaa gctgtcattt taatcctcct tcatcgataa
    24601 aatagtaatg ttaatataac attttgttgg tttttttaca atatatctct aagtagaaag
    24661 attatataac aaaagtataa aaatacaatt ttagattgat tatacatctc cttaatttag
    24721 agtgtactca taaaatacgg ttctgttgca aagttgaatt tataatataa ttttaacaaa
    24781 aaggagtctt ctgtatgaac tatttcagat ataaacaatt taacaaggat gttatcactg
    24841 tagccgttgg ctactatcta agatatgcat tgagctatcg tgatatatct gaaatattaa
    24901 gagaacgtgg tgtaaacgtt catcattcaa cgatctaccg ttgggttcaa gaatatgccc
    24961 caattttata tcaaatttgg aagaaaaagc ataaaaaagc ttattacaaa tggcgtattg
    25021 atgagacgta tatcaaaata aaaggaaaat ggagctattt atatcgtgcc attgatacag
    25081 agggacatac attagatatt tggttgcgta agcaacgaga taatcattca gcatatgcgt
    25141 ttatcaaacg tctcattaaa caatttggta agcctcaaaa ggtagttaca gatcaggcac
    25201 cttcaacgaa ggcagcaatg gctaaaataa ttaaagcttt taaacttaaa cctgactgtc
    25261 attgtacatc gaaatatctg aataacctca ttgagcaaga tcaccgtcat attaaagtaa
    25321 gaaagacaag atatcaaagt atcaatacgg caaagaatac tttaaaaggt attgaatgta
    25381 tttacgctct atataaaaag aaccgtaggt ctcttcagat ctacggattt tccccatgcc
    25441 acgaaattag catcatgcta gcaagttaaa cgaacactga catgatatat tagtgattag
    25501 ctatattttt tactttgcaa cagaaccagc catttaatat gactgttaca attactaaga
    25561 ttcaagcact attacgccgc acgtatgatt tcaccactca agttaataat ttaacagtag
    25621 atgattgcga gttactactt gatgcagcaa agcttaaatt taatgaagaa accatagacc
    25681 tgacacacac tgaattgcaa atcatgcata gcttattcca gaacaagggc aaattcgtca
    25741 gtcgtaatgc gttaatcgaa aaatgctggg aatcagaaca cttcattgat gacaatacgc
    25801 ttgctgtcaa cattacacgt ttacgcaaaa agctacaaaa actaggactt acagatttta
    25861 tcgaaacgaa gaaaaatgtc ggatatcgtg taggtgacgt atgaatttct tgaaatcaat
    25921 ccaacgtgaa atttatattg tcatccttac ttgtgcttta ttctacttta tattattcat
    25981 gtataatgtg ccgatgcaag catatatgat tggtctaggt attgtattgt ttgtttcaat
    26041 gatttactgg ggtatccatt acatgaactt taaaaaagaa taaacactac aggaacagaa
    26101 cgaagattta agaatcgaaa accataaact tcgtaatgac tttattaact accaaagtga
    26161 gttagagtca tattttttaa tgtgggtgca tcaaatcaag acaccgatta cagcatcaaa
    26221 gttactgctt gaagatcctg atgaacacgt gatttctaac gtgcgtaatg aagtcttaca
    26281 aattgataat tacacgaatc ttgcactgaa ctatttgaaa ctcatgaacc aaaagacata
    26341 catggtcttt atggaagtga gtgtagatga attaattcga ccactgatta aacgttatgc
    26401 gatacagttt attcatcatc aaacaaagtt gcattatgag aaaagtgaag cggttatatt
    26461 aacagatgcc aaatgggcat caattatgat tgagcaaata ttaaacaatg cattaaaata
    26521 tgcacgtggc aaagatgtgt ggattacgtt tgacgaaaat acaaagaaat tatcaatccg
    26581 agataacggt atcggcatta atgcgagtga tttaccgaaa atctttgata aaggtttctc
    26641 gggctataac ggtagaataa gtgagaaatc aagcggtatt ggtttatata ttgtcagcac
    26701 aatctcaaag cgcttaggcc ataaagtaag tgctacatct acattaaacg atggttcaat
    26761 attcaccatt caatttaaat aactccaatc tttcattttt gtaagattag cggctgtttt
    26821 tgtaagaata gataaaggca gccttttcta atcgcgcgta agataaaggt aacaacaaac
    26881 taagaaaggt gccagaggtg aaaaatttga ataatataat tgaaataaat aacttaacaa
    26941 agcaatatgg aagtcagata gcagttaata atttgagtat aactgttgaa agtggacaaa
    27001 tttatggttt tttaggaaga aatggtgcag gcaaaacaac tactataaga atgcttttag
    27061 gcttaatt
//
