LOCUS       NZ_CP031671            18320 bp    DNA     circular CON 16-MAY-2024
DEFINITION  Staphylococcus aureus strain 64 plasmid pPS00119.1A.1, complete
            sequence.
ACCESSION   NZ_CP031671
VERSION     NZ_CP031671.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN08997834
            Assembly: GCF_003425915.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 18320)
  AUTHORS   Chako,K., Divya,B., Pak,T., Sause,W., Kumar,K., Sebra,R., Deikus,G.,
            Attie,O., Rose,H., Lewis,M., Li,Y., Bashir,A., Kasarskis,A.,
            Schadt,E., Richardson,A.R., Torres,V. and Shopsin,B.
  TITLE     Colonizing and infecting subclones diverge during Staphylococcus
            aureus infection
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 18320)
  AUTHORS   Chako,K.I., Sullivan,M.J. and van Bakel,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-AUG-2018) Genetics and Genomic Sciences, Icahn School
            of Medicine, One Gustave L. Levy Place Box 1498, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2017
            Assembly Method                   :: HGAP v. 2.2.0
            Expected Final Version            :: yes
            Genome Coverage                   :: 27.8076425097x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003425915.1-RS_2024_05_16
            Annotation Date                   :: 05/16/2024 01:51:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,917
            CDSs (total)                      :: 2,835
            Genes (coding)                    :: 2,762
            CDSs (with protein)               :: 2,762
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 73
            CDSs (without protein)            :: 73
            Pseudo Genes (ambiguous residues) :: 0 of 73
            Pseudo Genes (frameshifted)       :: 40 of 73
            Pseudo Genes (incomplete)         :: 35 of 73
            Pseudo Genes (internal stop)      :: 11 of 73
            Pseudo Genes (multiple problems)  :: 13 of 73
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031671.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..18320
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="64"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pPS00119.1A.1"
                     /geo_loc_name="Germany"
                     /lat_lon="51.9636 N 7.6132 E"
                     /collection_date="1994"
                     /collected_by="University of Munster"
     gene            1..552
                     /locus_tag="DD547_RS15095"
                     /old_locus_tag="DD547_00001"
     CDS             1..552
                     /locus_tag="DD547_RS15095"
                     /old_locus_tag="DD547_00001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002508689.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_050956587.1"
                     /translation="MAKIGYARVSTQDQSLDGQIDTLEEYGCERIFSEKASGRKTKRTE
                     LDKCLDYLREGDILVIYKLDRLGRTTKQLIELSQWLDDNSIDLHIINMNVSTKDAMGKM
                     FFTMMSAFAELEANLLSERTKKGLEAARARGRKGGRPSLPDHKKREIKFLYDEQKLTGE
                     DIAKQTGVSRSTVYRIIKMK"
                     /name="recombinase family protein"
     gene            complement(699..1373)
                     /locus_tag="DD547_RS15100"
                     /old_locus_tag="DD547_00002"
     CDS             complement(699..1373)
                     /locus_tag="DD547_RS15100"
                     /old_locus_tag="DD547_00002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001106019.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRGRGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMAKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(<1429..1647)
                     /locus_tag="DD547_RS15105"
                     /old_locus_tag="DD547_00003"
                     /pseudo=""
     CDS             complement(<1429..1647)
                     /locus_tag="DD547_RS15105"
                     /old_locus_tag="DD547_00003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010889940.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid recombination protein"
                     /name="plasmid recombination protein"
     gene            complement(1833..3212)
                     /gene="tet(K)"
                     /locus_tag="DD547_RS15110"
                     /old_locus_tag="DD547_00004"
     ARG             complement(1837..3212)
                     /name="tet(K)"
                     /gene="tet(K)"
                     /gene_name="tetracycline efflux MFS transporter Tet(K)"
                     /tool="amrfinderplus"
                     /drug_class="TETRACYCLINE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(3374..4318)
                     /locus_tag="DD547_RS15115"
                     /old_locus_tag="DD547_00005"
     CDS             complement(3374..4318)
                     /locus_tag="DD547_RS15115"
                     /old_locus_tag="DD547_00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000277654.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003916 - DNA topoisomerase activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation factor domain-containing
                     protein"
                     /protein_id="WP_000277654.1"
                     /translation="MYKNNHANHSNHLENHDLDNFSKTGYSNSRLDAHTVCISDPKLSF
                     DAMTIVGNLNRDNAQALSKFMSVEPQIRLWDILQTKFKAKALQEKVYIEYDKVKADSWD
                     RRNMRIEFNPNKLTRDEMIWLKQNIISYMEDDGFTRLDLAFDFEDDLSDYYAMSDKAVK
                     KTIFYGRNGKPETKYFGVRDSNRFIRIYNKKQERKDNADAEVMSEHLWRVEIELKRDMV
                     DYWNDCFSDLHILQPDWKTIQRTADRAIVFMLLSDEEEWGKLHRNSRTKYKNLIKEISP
                     VDLTDLMKSTLKANEKQLQKQIDFWQHEFKFWK"
                     /name="replication initiation factor domain-containing
                     protein"
     gene            complement(4475..5149)
                     /locus_tag="DD547_RS15120"
                     /old_locus_tag="DD547_00006"
     CDS             complement(4475..5149)
                     /locus_tag="DD547_RS15120"
                     /old_locus_tag="DD547_00006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001106022.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRGRGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(5179..6336)
                     /locus_tag="DD547_RS15125"
                     /old_locus_tag="DD547_00007"
     CDS             complement(5179..6336)
                     /locus_tag="DD547_RS15125"
                     /old_locus_tag="DD547_00007"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="PHP domain-containing protein"
                     /protein_id="WP_050956586.1"
                     /translation="MDKGSEWIRWDLHVHTRSSEDYKYMHDDAEEKLVEEWKKQGIKAV
                     AITDHFTIDSDRINKLRELAKGEITIFPGVELRTDKGSTNIHVIGIFSEHKNLKELQND
                     FEAIMLRRNPNKDKFEKIFWDFNDIEKFIRDRQGIITIHAGNKSNSIEEISNDSAFNMA
                     IKESYSHKVDIFEHNNTHSCKGYEKSVFKVTGIKPQIVCSDNHNPLDYQYSDKLWIKSQ
                     PTFKGLLQAIKHPTERIYIGPEPQKIKHEKFNKQYIIEEIEICKNKNSSTYDMWFDTKI
                     PLNSSLTAIIGNKGSGKSALSDIIALTGESDKVDENNASFLNNKRFNKSPQKYGDNYES
                     TLTWKDKHENKTNSLMLKKSDNYNNYVQYLPQKYIEKGSVAKLNL"
                     /name="PHP domain-containing protein"
     gene            complement(6514..6609)
                     /locus_tag="DD547_RS15130"
     CDS             complement(6514..6609)
                     /locus_tag="DD547_RS15130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_000889979.1"
                     /translation="MLEILVHITTTVISGCIVALFTHWLRNRNDK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(6904..7389)
                     /locus_tag="DD547_RS15135"
                     /old_locus_tag="DD547_00008"
     CDS             complement(6904..7389)
                     /locus_tag="DD547_RS15135"
                     /old_locus_tag="DD547_00008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002455937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_050956585.1"
                     /translation="MKKFSKIVLASGIVLGFSVTPELFNATEAQAQESIEPYYSYDGYT
                     AYQSGFILDKNFKESLKYDNFTINGYQISKNQTGNNRINLYDQTLYGVSENKANGVFFS
                     LDGKSINKNTLIQNYGQPNSYSPTSAWGEEYMYKIGNKDVRFYIYNGYVIKCQIISE"
                     /name="hypothetical protein"
     gene            complement(8477..8659)
                     /locus_tag="DD547_RS15385"
     CDS             complement(8477..8659)
                     /locus_tag="DD547_RS15385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002500874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_050956584.1"
                     /translation="MKIFLYFIYFFVSFFIFKSLFDLVIPAIDFHLYLNLISALFFGLF
                     MTLLDFVLKKNKNKK"
                     /name="hypothetical protein"
     gene            complement(8803..9477)
                     /locus_tag="DD547_RS15150"
                     /old_locus_tag="DD547_00010"
     CDS             complement(8803..9477)
                     /locus_tag="DD547_RS15150"
                     /old_locus_tag="DD547_00010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105994.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKVAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            9610..10167
                     /locus_tag="DD547_RS15155"
                     /old_locus_tag="DD547_00011"
     CDS             9610..10167
                     /locus_tag="DD547_RS15155"
                     /old_locus_tag="DD547_00011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016425720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_050956596.1"
                     /translation="MYNINSSKIIKGSLAFVIASGVVFSPVGIDNDSEAAEANSSMVSK
                     KSAGTISKINDNVARIDLNKGITYNVDENGIATIKDTHSGKTEQLPVTAKDKNGEDATL
                     VYFEEDGKLGVQVVKQQQERGAAKCVIGTVGGAIGGATTGGLGGAAVGTVTLPIVGTVS
                     GGVVGTIGGGIGGASGGYVAGC"
                     /name="hypothetical protein"
     gene            complement(10642..10743)
                     /locus_tag="DD547_RS15160"
     CDS             complement(10642..10743)
                     /locus_tag="DD547_RS15160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_000228874.1"
                     /translation="MVEALVHITTTVISGCIVALFTHWLRTRNNKKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(10905..11252)
                     /locus_tag="DD547_RS15165"
                     /old_locus_tag="DD547_00012"
     CDS             complement(10905..11252)
                     /locus_tag="DD547_RS15165"
                     /old_locus_tag="DD547_00012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_050956595.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSIASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNQEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(11271..11888)
                     /gene="cadD"
                     /locus_tag="DD547_RS15170"
                     /old_locus_tag="DD547_00013"
     ARG             complement(11275..11888)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="99.51"
                     /coverage="100.0"
     gene            complement(13156..13485)
                     /locus_tag="DD547_RS15180"
     CDS             complement(13156..13485)
                     /locus_tag="DD547_RS15180"
                     /inference="COORDINATES: protein motif:HMM:NF013603.4"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /protein_id="WP_307833771.1"
                     /translation="MISLINNSNDFITLKKTSKYSVKSSDFLTDDDEKNQEILSDLKKG
                     LYRKRMLSYGGLLKQKHKILNLDDAEDGNLINTSDEDKTTDEEEKAHSITAIWNFEKQN
                     YYLRH"
                     /name="protein rep"
     gene            complement(13466..14410)
                     /locus_tag="DD547_RS15185"
                     /old_locus_tag="DD547_00015"
     CDS             complement(13466..14410)
                     /locus_tag="DD547_RS15185"
                     /old_locus_tag="DD547_00015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_031903320.1"
                     /translation="MPNFEKYNLSQVKTERFYQLPKYLFEDAYFKKMSAEAKIMYALLK
                     DRFELSIQNEWVDRNNNIYFIFSNKHLCEYLGYAEQKIIKLKKELVNFNLLTQERVGLN
                     KPNRLYLLKPNYDIEASLTKELPNSQFQNNEFGSSRTVNLSGQELPNSQSNDTELNNTN
                     YIENEDNDTYDMNDIISNALINNNHHSNHTNHQKTEFNNDALKFQVLEELPQQLQDYLS
                     KFEIREIRIIKSVLLKGKKSFNTSHNTYYRLEDVEFEIVSVLKRFKAMLLQKNETVEAM
                     QGYLMQSIKAELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            14855..15625
                     /locus_tag="DD547_RS15190"
                     /old_locus_tag="DD547_00016"
     CDS             14855..15625
                     /locus_tag="DD547_RS15190"
                     /old_locus_tag="DD547_00016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_050956590.1"
                     /translation="MKTIKMVADELNVTKQTIVNNAKSLNISFEKENGINYINDNDCLK
                     IIEKITKKERTMQKKESIKKERFNENTAEFEKHIYNNSNSFESLKTKVNELEKQIEIFE
                     TRAKNDEKYIENLTKQLDQQNSNVNTLNKLLENQQILALESNKKIQKLENQLEEERQLN
                     YSFDTATNDRENINPQEATFTEEYQNINQQQKKIQPIEPELNHKGITEAKNDDSANEDV
                     LKREDKLSEEIESGPEDREVETPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(15690..17012)
                     /locus_tag="DD547_RS15195"
                     /old_locus_tag="DD547_00017"
     CDS             complement(15690..17012)
                     /locus_tag="DD547_RS15195"
                     /old_locus_tag="DD547_00017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001281642.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="WP_050956589.1"
                     /translation="MSDLLLLPDLKTIEPPQENESDMMFKVEATFPPVRCPQCGFDRLY
                     KHTSRKQLIMDLPIRLKRVGLQLNRRRYKCRECGTTFWERLISIDEKRSMTKRLIRSIE
                     EQSLSKTFVDVAESVGVDEKTVRNIFKDYVALKEREYQFETPKWLGIDEIHIIKKPRLV
                     LTNVERRTIYDIKPNRNKDTVIQRLSEIKDNTYIEYVTMDMWKSYKDAVNTVIPHAKVV
                     VDKFHVVRMANQALDSVRKSLKANMTAKESRTLMRERYILLKRKHDLNERDSFLLDTWL
                     SNLPELKEAYELKEEFYLIWDTDDLEQAKDRYRYWRQCCLSSNSKNAYKDLLRAVDNWQ
                     DEIFNYFDKRLTNAYTESINSIIRQVERMGRGYSFEALRAKIIFNEKLHKKRKPRFNSS
                     AFSKAMLYDSFNSYQITDRDKTGNYGVDFSTLIKKLEKSNL"
                     /name="ISL3 family transposase"
     gene            complement(17376..17720)
                     /locus_tag="DD547_RS15205"
                     /old_locus_tag="DD547_00019"
     CDS             complement(17376..17720)
                     /locus_tag="DD547_RS15205"
                     /old_locus_tag="DD547_00019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002485687.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_050963111.1"
                     /translation="MSENWCIPKPKLTERPLLDTEDAEGLSETFKILSNGTRLRILHTL
                     LRTPNASVSEVAEQLEMKPQAISNQLQRLVDKGIVRSIREANFIRYRIVDNCVVSLLDR
                     GWCLTEDLPK"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     Typing          complement(3375..4318)
                     /name="rep_cluster_1118"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(13159..13335)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="93.82"
                     /coverage="94.0"
                     /evalue="1.33e-69"
     Typing          complement(13467..14410)
                     /name="rep_cluster_1215"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="98.519"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 atggctaaaa ttggttatgc acgtgtatca acgcaagatc aaagtcttga tggacagatt
       61 gatacacttg aggaatatgg ttgtgaacgt atctttagcg agaaagcgag tggtcgcaaa
      121 acgaaacgaa cggaacttga taaatgctta gattatttac gtgaaggcga tattttagtt
      181 atctataaac tagatcgtct tggccgaaca accaagcaat taattgagtt atctcaatgg
      241 ttagatgata atagtattga tttacatatt ataaatatga acgtatcaac caaagatgcg
      301 atgggcaaga tgttctttac tatgatgagt gcatttgctg aacttgaagc taacttatta
      361 agtgaacgta cgaaaaaagg attagaagca gcaagagcta gagggagaaa aggtggaaga
      421 ccatcattac cagatcataa aaaaagagag attaaattct tatatgatga gcaaaaactt
      481 actggcgaag atattgctaa acaaacagga gtgagtcgtt ctactgtata tagaataata
      541 aaaatgaagt agtaaaaaca aataatcaca ggaagaaaac taatgaaagg agaatctcta
      601 atttgaagat tctcctttca ttagttttta taacctatat ggttctgttg caaagtaaaa
      661 aatatagcta accactaatt tatcatgtca gtgttcgctt aacttgctag catgatgcta
      721 atttcgtggc atggcgaaaa tccgtagatc tgaagagacc tgcggttctt tttatataga
      781 gcgtaaatac attcaatacc ttttaaagta ttctttgctg tattgatact ttgatacctt
      841 gtctttctta ctttaatatg acggtgatct tgctcaatga ggttattcag atatttcgat
      901 gtacaatggc agtcaggttt aagtttaaaa gctttaatta ctttagccat tgctaccttc
      961 gttgaaggtg cctgatctgt aattaccttt tgaggtttac caaattgttt aatgagacgt
     1021 ttaataaacg catatgctga atgattatct cgttgcttac gcaaccaaat atctaatgta
     1081 tgtccctctg catcaatggc acgatataaa tagctccatt ttccttttat tttgatgtac
     1141 gtctcatcaa tacgccattt gtaataagct tttttatgct ttttcttcca aatttgatat
     1201 aaaattgggg catattcttg aacccaacgg tagaccgttg aatgatgaac gtttacacca
     1261 cgtcccctta atatttcaga tatatcacga taactcaatg catatcttag atagtagcca
     1321 acggctacag tgataacatc cttgttaaat tgtttatatc tgaaatagtt catacagaag
     1381 actccttttt gttaaaatta tactataaat tcaactttgc aacagaacca tttttctttt
     1441 gcctgtataa ttctgttcga ttttttcatc aatcaagtta ttaaaattct gtttattagc
     1501 atttaccaaa tcataattta agtaagtttt actatggtct atatcttcat tttcataatt
     1561 attattttct ctttgaacat gtttttgtat gcccgttgta tttgttccag atttaacttt
     1621 tgaaactcta acaatggaat aagacatata aaaatcactc ctaagcacaa aggtttcatg
     1681 tgtatttaat agtttaagtc taacacacta gacttatttt taataagtcg ttaatacgtg
     1741 tgctctgcga ggcttaaacc tgtttttgct aacgcaaaaa atgagtggca aaatgctagc
     1801 cactcatagt tctaaaccaa aatataatat aactattcaa actgcttttc agaacgttta
     1861 aatacaataa tcgtcaaaag acaacataaa ataataagga tagccatggc tacaagaata
     1921 ttactataca ctccagaaga ataatttata aattccagaa ctagtttacg attaatcaat
     1981 tgtagtgaca ataaacctcc tacaattgct atacctgttc cctctgataa aaaacttgtg
     2041 aaatttagca aactcattcc agaagcaact tcttcttcag aaagactact tgatactatt
     2101 tttgatataa ctgttttagt aaaagataat ccgcccataa caaatataaa cataaaagta
     2161 gtcaaccaca tactaaactc aacaaaaaat gcaatagtta aaaaacttat agagatagac
     2221 aatgatccta aaataaaaac aaataatgat ccttttctat ccactaaaaa accaccaaaa
     2281 taaccaaaaa caataacact catggttcca ggaaaaataa cactattacc tattgtcgct
     2341 acatttacat gataaatagt tttcatcata taaggcacca ttgatataaa accagctact
     2401 atagaaaata ttagcccacc agaaaacaaa ccaagcataa acggaatgtt tttccctagt
     2461 ttaggattaa taaaagggtt agaaactctt gaaatatgtt taataaaaat cacaaaaaag
     2521 attgtgaaga gtattaaaaa agtccaatta taatttgtcg taaataacat aaaacatata
     2581 atacttatag acattaaaac aatacctacg atatctaatg tattttttgt tgatttacca
     2641 ggtaccatta ctttaataag aaaaggtata gttactattg taatcatagg aagtataagt
     2701 aggtaagacc aatgaatata atgtgctatt attcccccta ttgaaggacc taacccttca
     2761 cctaaagcta caattgatcc tataaaacca aaggctttgc cttgtttttt tcttgtaata
     2821 tttctagcta caaccaccat aatcagtgaa gggaatgcag cagatcctac tccttgtact
     2881 aacctaccaa aaatcaaaat aaaaaagtga ttgtgaccaa taaaagcaat caatgaacca
     2941 agacagctca aactaatacc aataattaac aattttttta tatttatata atcagataat
     3001 tttccatata ctgctgttcc tatcgaaaaa gttaacatat atgcagtgtt tacccagttt
     3061 gtaattccag gagtagtatt aaaatgattt gcaatatcag gtaaagaaac atttaaaacc
     3121 atttcattta atacactaaa aaatgaaaga atacaaagcc aaaataaaac gctataaaac
     3181 aaacctttaa attttttata taaactaaac aattttacct ctttacttga ggtgactaaa
     3241 gtttataggg gtaaattatt ctttcacctc atataaattc cccaaatttt taaatagaca
     3301 cttcataaaa aaatcctcct aaattagaat agtttaaata tatcattttt gttcagtaat
     3361 attaatatgt acactatttc caaaatttaa attcatgttg ccaaaaatcg atttgttttt
     3421 gcaattgttt ttcgttcgct tttaaagtcg atttcattaa gtccgttaaa tcgactggcg
     3481 aaatttcttt tatcaaattc ttatattttg ttctagaatt tctgtgaagc tttccccatt
     3541 cttcttcatc actcaataac ataaaaacta ttgctctatc cgcagtgcgt tggatagttt
     3601 tccaatctgg ttgcaagata tgtaaatcac taaagcaatc attccagtaa tccaccatat
     3661 ctcttttaag ttcgatttct acacgccata aatgttcaga cataacttca gcatctgcat
     3721 tatctttacg ttcttgcttt ttattataaa ttctaataaa tctattacta tctctcacgc
     3781 caaaatattt tgtttctggc ttaccattac gaccataaaa aatagttttc ttaactgctt
     3841 tatcagacat tgcatagtag tcactcaaat catcttcaaa atcaaaggct aaatctaatc
     3901 ttgtaaaacc gtcatcttcc atgtagctta ttatattttg ttttaaccaa atcatttcat
     3961 ctcgtgtaag tttgtttgga ttaaattcaa tacgcatatt acgtctatcc caactatctg
     4021 ctttcacttt gtcatattca atataaactt tttcttgaag tgctttagct ttaaactttg
     4081 tttgaagaat atcccaaagt cttatttggg gctctacact cataaattta gaaagggctt
     4141 gagcgttgtc tcggttgaga tttccaacga tcgtcattgc atcaaaactt aattttggat
     4201 cagatatgca cacagtatgt gcgtccaacc ggctattaga gtagccggtt ttagaaaaat
     4261 tgtctaaatc gtgattttcc aaatgatttg aatgatttgc atgattgttt ttatacataa
     4321 aaaatcgact ccttaatctc aatttcgttt aaggaatcgc tcacccaaat atatatcttg
     4381 atgtatattt aaatatcgtt taatatctaa atataggttc tgttgcaaag taaaaaaata
     4441 tagctaacca ctaatttatc atgtcagtgt tcgcttaact tgctagcatg atgctaattt
     4501 cgtggcatgg cgaaaatccg tagatctgaa gagacctgcg gttcttttta tatagagcgt
     4561 aaatacactc aatacctttt aaagtattct ttgctgtatt gatactttga taccttgtct
     4621 ttcttacttt aatatgacgg tgatcttgct caatgaggtt attcagatat ttcgatgtac
     4681 aatggcagtc aggtttaagt ttaaaagctt taattacttt aaccattgct accttcgttg
     4741 aaggtgcctg atctgtaatt accttttgag gtttaccaaa ttgtttaatg agacgtttga
     4801 taaacgcata tgctgaatga ttatctcgtt gcttacgcaa ccaaatatct aatgtatgtc
     4861 cctctgcatc aatggcacga tataaatagc tccattttcc ttttattttg atgtacgtct
     4921 catcaatacg ccatttgtaa taagcttttt tatgcttttt cttccaaatt tgatataaaa
     4981 ttggggcata ttcttgaacc caacggtaga ccgttgaatg atgaacgttt acaccacgtc
     5041 cccttaatat ttcagatata tcacgataac tcaatgcata tcttagatag tagccaacgg
     5101 ctacagtgat aacatccttg ttaaattgtt tatatctgaa atagttcata cagaagactc
     5161 ctttttgtta aaattatact ataaattcaa ctttgcaaca gaaccttttt ctatatactt
     5221 ttgcggtaaa tactgtacat aattattata attgtctgat tttttaagca ttagactatt
     5281 ggttttattt tcatgtttat ctttccacgt taatgttgat tcatagttat ctccatattt
     5341 ttgtggtgac ttattaaatc tcttattgtt taaaaaagaa gcattatttt catcaacttt
     5401 atctgattct ccggttaatg ctataatatc ggataatgcg ctcttcccac tacctttatt
     5461 accgataata gctgttaaac ttgaatttaa tgggattttt gtgtcgaacc acatatcata
     5521 agttgaagaa tttttatttt tacaaatctc tatttcttct ataatatatt gtttattaaa
     5581 tttttcatgt ttaatttttt gtggttctgg accaatatat atacgctctg tcggatgctt
     5641 tatagcttgt aataaacctt taaatgtagg ctgagacttt atccataact tatctgagta
     5701 ttgataatct aatggattat gattatcaga acaaacaatt tgaggtttta taccagtaac
     5761 tttaaataca cttttttcat aacccttaca cgaatgagta ttgttatgct caaatatatc
     5821 aactttatga ctataagatt ctttaattgc catattaaat gcgctgtcat tacttatttc
     5881 ttctatacta tttgacttat taccggcgtg tattgtaatt ataccttgtc tatctcttat
     5941 aaatttttca atatcattaa aatcccaaaa tatcttttca aatttatctt tatttggatt
     6001 tcttctaagc attatagctt caaaatcatt ttgaagctct tttaaatttt tatgctcaga
     6061 aaatattcca attacatgaa tattagtaga tcctttatct gtccttaatt ctactccagg
     6121 aaaaattgtt atttctcctt tagctaactc tcttaattta ttaattctat ctgagtctat
     6181 agtaaaatga tctgttattg ctactgcttt aattccttgt tttttccact cttccactaa
     6241 cttttcttca gcgtcatcat gcatatattt ataatcttct gacgaacgag tgtgaacatg
     6301 caaatcccat cgaatccact ctgatccttt atccatttgt attgtctcct tttttgttta
     6361 tattatactt taatttaaat ttaattatat gttattttgc attcctctat taaccagtgt
     6421 tataatgtga ttaacaagaa ttctagcgtg aatacaccaa tcccctcact attgcagtag
     6481 tgaggggatt tttttaggtg tggctatagt cgcctattta tcgttgcgat tacgtagcca
     6541 atgcgtaaat aacgcaacaa tacaaccact gatgactgtg gtcgtgatgt gaacaagaat
     6601 ttctagcatg aataacacct cctctctgcg tctaagtttg acgcctgaga gataggcgac
     6661 tctattatta tatcatctgt gaatatacaa acatatctac ttccgataag tcgtcttatg
     6721 ttatataact ttgtttttta tagtatcaag acaagaagat catcctccaa aaaaagagat
     6781 taaacaacct aaggttgctt aatctcaata tttggactca tcagtccgat ttgacgtaga
     6841 gccataaaaa aacgtgaagt aagtgaactt gcaacttacc tcacgtttta tacctaaact
     6901 gtcttattca cttataattt gacatttaat cacatagcca ttgtaaatat aaaatctgac
     6961 atctttatta ccaattttgt acatatattc ttcaccccat gctgaagtag gagagtaaga
     7021 atttggttgg ccataatttt gaattaaagt atttttatta atagattttc catcgagaga
     7081 gaagaaaaca ccgttagctt tattctcaga cacaccataa agggtttgat cgtataaatt
     7141 tattcgattg ttacctgttt gattttttga tatttgatag ccgttgatag taaaattgtc
     7201 gtatttcaat gactctttga aatttttgtc taatataaat ccactttgat acgcagtata
     7261 accatcataa ctataataag gttcaataga ctcttgcgcc tgtgcttccg ttgcattaaa
     7321 tagttcgggc gttacagaga aacccaaaac aataccgcta gctagaacaa ttttagaaaa
     7381 tttcttcata aaaaccctcc taattattta taattcatct ataattatta cagaaatgta
     7441 acaaaaagtc atccggatta caaaaatatt acaaaaaatt catctttttt agaaaatgca
     7501 atttgtcata ctttccattc tattttattt ctttaaacag tttaaaataa ataatacttt
     7561 gcttttcatt taacatttta tagttaatta aaatagtctt aactgaaagt gaaaaacaag
     7621 aaattaatca tcaaatgatt gatgaaattg aagaagaaaa ttgaaaataa aatttggtat
     7681 ttttcttaaa cgttagcaaa aaagctagcg tttttttgtt taaaatagtt caaaaatgtc
     7741 tgggtacaaa cggggtacaa ggaaagtaaa atggtataaa aggtaaaacg cttgtatccc
     7801 ttgaaatgtc tggcttcgcc agacctacca tttttaaatg gtagcagatt tcccttatgc
     7861 tcttacaaag aatttggagc caattcaaaa ttttggtgtt ttaaaagaaa aaatgcctct
     7921 gcaagaacta aaaaacagaa ctactttttg aatgatttta tgccaatttt taatttgcat
     7981 ataactgggc agtgtgtaaa aaatcgacac tggttaagta aaaaatttag gtttgtcttt
     8041 ctgattttta aatttagttc atactttcgt tttaagagcc attaaatagc tttaggtaaa
     8101 ataatatata aaataccttt tatggaggtg tcagaatgaa aaaaccttct attttggcag
     8161 gaataataat cctactactt ataatttgca gtatagtatt gaacttaatc aatattccca
     8221 gtgaagccaa tatcgcatac tcaataacag ccattataat tattatctta ttgttcttta
     8281 ttattcctaa aaataacaaa ttataatatt gctttattcc aattgcttta ttgacgttga
     8341 gcctcggaac ccttaacaat cccaaaactt gtcgaatggt cggattaata gctcacgcta
     8401 tgccgacatt cgtcttcaag tttagttaag ggttcttctc aacgcacaat aaattttctc
     8461 ggcataaatg cgtgttctat ttcttgtttt tattcttttt taatacaaaa tcgagtagtg
     8521 tcataaaaag tccaaaaaat aatgcagata tcaggttcaa atatagatga aaatcaattg
     8581 ctggtattac taaatcaaat aaagatttaa aaataaaaaa cgaaacaaaa aagtatataa
     8641 aatataaaaa gattttcaaa acaaaaccac ctctccgaaa aatctatcac actaaatccc
     8701 aaagtttaaa ataccttttt ttgcaatttt aagatacttt ttagggttct gttgcaaagt
     8761 aaaaaatata gctaaccact aatatatcat gtcagtgttc gtttaacttg ctagcatgat
     8821 gctaatttcg tggcatgggg aaaatccata gatctgaaga gatctacggt tctttttata
     8881 tagagcgtaa atacattcaa taccttttaa agtattcttt gccgtattga tactttgata
     8941 tcttgtcttt cttactttaa tatgacggtg atcttgctca atgaggttat tcagatattt
     9001 cgatgtacaa tgacagtcag gtttaagttt aaaagcttta attattttag ccattgctac
     9061 cttcgttgaa ggtgcctgat ctgtaactac cttttgaggt ttaccaaatt gtttaatgag
     9121 acgtttgata aacgcatatg ctgaatgatt atctcgttgc ttacgcaacc aaatatctaa
     9181 tgtatgtccc tctgtatcaa tggcacgata taaatagctc cattttcctt ttattttgat
     9241 gtacgtctca tcaatacgcc atttgtaata agctttttta tgctttttct tccaaatttg
     9301 atataaaatt ggtgcatatt cttgaaccca acggtagacc gttgaatgat gaacgtttac
     9361 accacgttcc cttaatattt cagatatatc acgataactc aatgcatatc ttagatagta
     9421 gccaacggct acagtgataa catccttgtt aaattgttta tatctgaaat agttcataca
     9481 gaagactcct ttttgttaaa attatattat aaattcaact ttgcaacaga accagcaaaa
     9541 atatgatatg ttatatattg ggatgtttat taagggattg tttaaattct gaaataagga
     9601 gtttttacaa tgtacaatat taatagttca aaaattataa aaggttctct tgcatttgtc
     9661 atcgcttctg gagttgtatt tagccctgtt ggcatcgaca atgattctga agctgctgaa
     9721 gctaattcat caatggtttc taaaaaaagt gctgggacaa tttcaaaaat taatgataac
     9781 gtggctagaa ttgatttgaa caaagggatt acatacaatg ttgatgaaaa tggtatagct
     9841 acgataaaag atactcattc tggaaaaact gagcaattac ctgtaacagc aaaagataaa
     9901 aatggcgaag acgcgacttt agtttatttt gaagaggatg gtaagttggg tgttcaagtt
     9961 gttaagcagc aacaagaaag aggagctgct aaatgtgtaa tcggaactgt aggaggagct
    10021 attggtggtg cgacaactgg tggcttagga ggggctgctg ttggtactgt tacacttcct
    10081 attgttggaa ctgttagtgg tggtgttgta ggaactatcg gtggcggtat tggcggtgct
    10141 tctggcggat atgtagctgg ttgttaaaag gtgggataac tatgtatgat agaaaaatct
    10201 tcaactggcc aatatttttt attgtgattt tgagttatgt atttatgtta tcgttgtttt
    10261 tatgggtttc taatataagt catttaaaag tctttttatt gactattcct tttcttttaa
    10321 tgacttgtgt ttatataata ctgtttataa aaaatagata gttagttttt acacgtgttt
    10381 atgtatttca taagcacgtg tatttatgta tttttggaaa cgagtgtaac gagtttcttc
    10441 tggttctgtt gcaaagaaaa agattgttag aaatcctata aaactctcta ttttatttca
    10501 tcctcctata tagatactaa ttttgcattc ttctactaac cagtgttata atttagacaa
    10561 caagagcttc gtacattata tgcaccaatc ccctcactac tcgcaatagt gaggggattt
    10621 ttaggtgttg gctaatatcg cctatttttt cttattgtta cgtgtacgta gccaatgcgt
    10681 aaataacgca acaatacaac cactgatgac tgtggtcgtg atgtgaacaa gagcttcgac
    10741 catctgatat gcacctcctc tctgcgtcta aattgacgcc tgagagatag gcgacctgta
    10801 tattatatca tctctgaata agggataata gataacttcc gataagtgat tttatgttat
    10861 atctttgctt atttttatag tatcaagaca ggaagaaact cgtttcaaaa accctcctga
    10921 tttttagaga aaaactctct tatttcatcg tctttaataa aataatatgc catctttcca
    10981 tctttataaa aatcaagcac ctcattttta tataaaagtc ttaaatgatg tgaagttgaa
    11041 gcaatactca ttttcaatat caaagaaata tcacaaacac acaactcatc ttctttaatc
    11101 aaagataata tgattttcaa ttttttctca tcacaaattt tttctaaaat gttaagtaat
    11161 ttcttagatt tatcatcttc taaaaaactt aaagcattgt taactttatc ctcatgtaca
    11221 cagatcacat cacaagtatt ttcataactc atataaaatc acaccctaaa ttaaaatata
    11281 aatcctaaaa ttgtttgaat agtgtcattt tcaataataa taaataaacc taaagctata
    11341 taaatgatag ccataatcca acgactaaat ttctcaacaa tttctccaat tcctgggata
    11401 ttagctaatt tttgtgcagt aaacaccaag aagaaaatta aaattaaaaa gacaaacaga
    11461 gtaagtaata aattagtaac acttaatgtc acaaaatacg gaacaaataa accaatatta
    11521 tcggcgccac aacttgctat cgtaacaatt gcaaccgtac caactaattt agacaatcct
    11581 ttttcattca attctttttt agctctcttt tctccttcac aatcatcata aatagccact
    11641 ttaattccaa gataaattgg tattaaaccc aataaaccta atatccactt ttctggaaca
    11701 taatttaata caaaagctaa aaacaaacta actaatatta aaataataga ccctaaatat
    11761 tgaccaacat aaatatttct atattctttt ctagtctttg ctctagcaaa aaatattaat
    11821 aaaattacta ataaatcaac tgctgtagca atataaagaa cagcagcagc aacaaccgtt
    11881 tgaatcataa tacacctcat tcaaaaatat ttttgaatgt attataactt atatttttaa
    11941 ataatcatag gtgctttatt ccaattgctt tattgacgtt gagcctcgga acccttaaca
    12001 atcccaaaac ttgtcgaatg gtcggcttaa tagctcacgc tatgccgaca ttcgtctgca
    12061 agtttagtta agggttcttc tcaacgcaca ataaattttc tcggcataaa tgcgtgtcta
    12121 tgcgtagaca tggagacact tcagaattat ggagtgatta catgagttta actatttttc
    12181 tttattcagt tttaggaagt ttattagcaa attatatcta cgaaaaatct tcaaaataaa
    12241 taactttttc ggttctactt tgtacacttt atctacctgg tagacctaat tgttattgct
    12301 ttacaggtct aaaattcgtc gttataatct agttaaatcc cgtaagggcg cacttatacg
    12361 tcggataaat cgacatgtgc aaaaacgtaa tcgaccttcg tcgatttttt tatttcaaaa
    12421 ttaaagaaac ggcttgagat attccgagca gttataaaaa ttaatttgcg ttgaatattg
    12481 ctactacatt cttgaaaaag tgatgtagat ttatagccca taactttttt gaattacatc
    12541 gacgatacgg cgtcgaaaga aaaataaata gaccgtatga aagaaaaagc tacctcactt
    12601 tatctggggg agcttttatt ttttatgccc ttattttgaa ttttaagagg gcattttaaa
    12661 gatttagggg tgattcatat agttttatat ctaaaactta tatacgcttt taaaacgcaa
    12721 atatgagcca aataaatata tgctattttc aaaaacaaaa atttgagcaa aaacaataac
    12781 tatttttaga cactgcccat ttacatgcaa attaaaaatt agcataaaat actttaaaac
    12841 ttccccatgt ttttctaaat tcctgcaggg cttttcttat caaaaactta gaaattttaa
    12901 tttaactcta aaatctccgt aagtaagagc ataagggaaa tatgacccca tctatagatg
    12961 aggtatctgg caaagccaga tatttcaaga cttcgtcggt ctttttgcat gggggcataa
    13021 aaagacgaaa tgtcacactt ttgtgacaca atatattgag tttgtcacag ttttgtgaca
    13081 ctacatacag catttgtcac aaaaataaga cagtactttt ttacaaaaaa tcaataaaaa
    13141 agacatcagt tatcactaat gtcttaaata ataattttgt ttttcgaaat tccaaattgc
    13201 cgtaattgaa tgtgcttttt cttcttcgtc tgtcgtttta tcttcatcac ttgtattaat
    13261 caaattacca tcttcggcat cgtctaagtt taaaatttta tgcttttgtt tcagcaatcc
    13321 accataactt aacatacgtt ttcgatacaa accttttttt aaatcactta aaatttcttg
    13381 atttttttcg tcatcatcag ttaaaaagtc agatgattta acggaatatt ttgatgtctt
    13441 tttgagtgtt ataaaatcat ttgaattatt gattaaagat attatattgt ttcatgtttt
    13501 tacggcgcat ataaagggca tgtgtttctt caagttcagc tttaatggat tgcattaaat
    13561 aaccttgcat agcttcaacg gtttcattct tttgtagcaa cattgcttta aaacgtttca
    13621 atacacttac aatttcaaat tcaacatctt ctaaacgata ataagtatta tgtgaagtat
    13681 taaatgactt tttccctttg agtaatacac ttttaataat ccgaatttct ctaatttcaa
    13741 atttacttaa atagtcttga agttgttgtg gcaattcttc gagtacttgg aacttaagag
    13801 cgtcattatt aaattcagtt ttttgatgat ttgtatgatt tgaatgatga ttattattta
    13861 ttaaagcatt agatataata tcattcatat catacgtatc attatcctca ttctctatat
    13921 aattagtatt atttaactca gtatcattag actgtgaatt tggaagttct tgaccactta
    13981 aattcacagt tctagaactt ccaaattcat tgttctggaa ctgtgaattt ggaagttcct
    14041 tggtaagact tgcttcaata tcataatttg gttttaataa atataatcta tttggtttat
    14101 tgaggccaac acgctcttga gttaataaat taaaatttac taactctttt ttcaatttta
    14161 tgattttttg ttctgcataa cctaagtact cgcacaaatg tttattactg aaaataaagt
    14221 aaatgttatt atttctatct acccattcat tttggatgga taattcgaaa cgatctttta
    14281 ataatgcata cataattttg gcttctgctg acattttctt aaaatatgca tcttcgaaca
    14341 aatatttagg caattggtaa aatctttcag tttttacttg tgataaattg tatttctcaa
    14401 aattgggcat aataaaaacc tcatttccac tttttggata gaggtaataa aacaattttt
    14461 acgtaggtta tatgttttgt gcttgcactt atatgattag atatatataa tacaagtatc
    14521 aaaaaattat ataaacagac gaatgcgaat cgttttatta ccgagagtcg atgctacgcc
    14581 aatagtatcg actcttttaa tattcacaaa gtaatattaa cacttttaag attgtatata
    14641 aagcttttta agtttagtta aaagaacgtt gtaactttaa aatgataaaa actcactact
    14701 ttagcaccta attaacggtt tgaaatcttc tataggtggc taattaggtg ctaaagtagt
    14761 gaattaggta gtaaatttag atgtcaaaag atgaaaaaat atttgttagg tggtaaaatt
    14821 taggtactaa tttaggtacc taaggatgaa tgttatgaaa actattaaaa tggttgctga
    14881 tgaattgaat gtaactaaac aaactattgt taataatgct aaaagcttaa atatatcttt
    14941 tgaaaaagaa aatggaatta attatattaa tgataatgat tgtttaaaaa ttatagaaaa
    15001 gatcactaag aaagaaagga caatgcaaaa aaaagaatca ataaaaaaag aaagatttaa
    15061 tgaaaatact gcagagtttg aaaaacatat atacaataat tcaaatagtt ttgagtcatt
    15121 aaaaacaaaa gtaaatgaat tagaaaagca aatagaaatc tttgaaacta gagctaaaaa
    15181 tgatgaaaaa tatattgaga atttaactaa acaactagat caacaaaata gcaatgttaa
    15241 tacattaaat aaactgttgg agaatcaaca aatattagct ttagaaagta ataaaaagat
    15301 tcaaaaacta gaaaaccaat tagaagaaga aagacagctt aattactctt ttgatacagc
    15361 gactaatgat agagaaaaca ttaatccgca agaagcaact tttactgaag aatatcaaaa
    15421 tatcaaccaa caacaaaaga aaatccaacc aatagaacca gaattaaatc ataagggtat
    15481 aactgaagcg aaaaatgatg acagtgcaaa cgaagacgta ttaaagagag aggataaact
    15541 atctgaagaa atagagagtg gacctgagga cagggaagta gaaacaccta aaaaggggtt
    15601 ttggagtcgt ttgtttggta gttaaaataa ttaattaggc actaaaagtt ataaactttg
    15661 ggtattcgga ttttatggtg gaaaagggcc tataagttac tcttttccaa tttcttaata
    15721 agtgtggaaa aatctacacc atagttgcct gttttgtctc ggtctgttat ttgatacgaa
    15781 ttgaaactat cgtataacat agctttgctg aatgcacttg aattaaatcg tggcttcctc
    15841 tttttatgga gcttttcatt aaaaattatt ttagctcgta aggcttcaaa tgagtaccct
    15901 ctacccattc gttctacttg cctaatgatg ctatttatag actctgtata agcgttagtg
    15961 agccttttat caaagtaatt gaagatttca tcctgccagt tgtctacggc tcttaatagg
    16021 tctttatagg cgtttttaga gttgctggat aaacagcatt gtctccaata cctgtaacga
    16081 tctttggctt gctcaaggtc atctgtatcc catatcaagt agaactcttc tttaagttcg
    16141 taggcttctt ttagttcagg taaattactt agccaagtat ccaaaaggaa tgaatctcgt
    16201 tcattcaagt catgctttcg tttaagaagg atatacctct cacgcataag ggtacgactt
    16261 tctttggctg tcatattggc tttaagagac ttcctaacac tatccaaggc ttgattagcc
    16321 attcggacta catgaaactt atctacaact actttagcgt gaggtataac tgtattaact
    16381 gcgtctttgt aggacttcca catatccatt gtgacatatt cgatatatgt attgtcttta
    16441 atttcagaaa ggcgttgaat gaccgtatct ttgttacgat tgggttttat gtcatatata
    16501 gttctacgtt ctacattggt caatacaaga cgaggtttct tgataatgtg tatttcgtca
    16561 ataccaagcc atttaggagt ttcaaactga tattcacgtt cttttaatgc cacatagtct
    16621 ttaaagatgt tcctaacagt tttctcgtct acaccaacac tttcagctac gtctacgaag
    16681 gtcttagaca gagattgttc ttcaatagac cttataagcc ttttagtcat actacgcttt
    16741 tcgtcaatgg atataaggcg ttcccaaaaa gttgtgccac attcacgaca tttataacgt
    16801 ctgcggttta attgtaatcc tactcgtttt aaacgaatag gcagatccat gattagttgc
    16861 tttcttgatg tatgtttata tagcctgtca aagccacatt gagggcaacg tactggtgga
    16921 aaagttgctt ccactttaaa catcatgtcg gattcatttt cttgtggtgg ttctattgtt
    16981 ttaagatctg gtagtaataa taagtctgac atattgttca tcctttacta ctctgtggtg
    17041 ttatagtatt aaatatagat ttgatattga aattatcatt gctaattatt ttactaacat
    17101 caatctcata aagcatttat atgattgaaa acaaaaagcc tatcattcac tatcctacaa
    17161 taaaaagggt tatcccatag ttacacggga taaccttaca attattaaat tatgcagttg
    17221 cacagctaca atctttgcac tcgcaaactt catcagtaca gttgtctaca cattcttgac
    17281 tacagtaaac ttttcctgct tcttctactt ttgtttcccc aagaagacaa ttacagttcg
    17341 gtctcgcaca tttttccata ctaaactcct ccttattatt taggtaaatc ttcggttaaa
    17401 caccaacctc gatctaatag actaacgacg caattatcaa caattcggta ccgaataaaa
    17461 ttggcttcac gaatactgcg aacgatgcct ttatcaacca atcgttgaag ttggttggaa
    17521 atggcttgag gtttcatttc aagctgttct gccacctcgc taacagatgc atttggagtt
    17581 cgaagcaagg tatgcagtat tctaagccgt gtcccgttag aaagtatttt aaaggtctca
    17641 cttaaacctt cagcgtcctc tgtatctaat aaggggcgtt ccgttagttt tggttttggt
    17701 atacaccagt tttcagacat tatttcctcc tccatttcac aattacatta tatagtgtag
    17761 tagtttttgt gtcaagaacc tgaagttcat atatgagcat ctttttatca gtacattata
    17821 acgccttaat aagataaaat ataattccct cttgtttgac tacctacccg taatcacccg
    17881 tgtttgattt ataattttgt ggtattatta tttttcctta gcattccacc aaacaatccg
    17941 atttaaccac tatttttttc gaattatcaa aatgctaatt ccactatata ttccgaagac
    18001 cctaaacttt tagtgccttt tatataatga gaacttctgg taattcaaca ttatgtaaac
    18061 taaagtattt caaataatta actgtattaa tactctcatc atgattgcgt tataaacgtt
    18121 cgtttttgat acaaaacctc ttaacttaat attaagaggt ttttcttgga tatcgaactc
    18181 taaaaacttg tgttataatc aatgtatcat aaataccaaa aaatatgagt tttcagacga
    18241 tgagagccgc gtttatttgc atcgagaact agatttcatt agtaagtact cataaaacga
    18301 ttaaaagagg tggtattcaa
//
