LOCUS       NZ_CP031668            18320 bp    DNA     circular CON 15-MAY-2024
DEFINITION  Staphylococcus aureus strain 199 plasmid pPS00120.1A.1, complete
            sequence.
ACCESSION   NZ_CP031668
VERSION     NZ_CP031668.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN08997833
            Assembly: GCF_003425545.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 18320)
  AUTHORS   Chako,K., Divya,B., Pak,T., Sause,W., Kumar,K., Sebra,R., Deikus,G.,
            Attie,O., Rose,H., Lewis,M., Li,Y., Bashir,A., Kasarskis,A.,
            Schadt,E., Richardson,A.R., Torres,V. and Shopsin,B.
  TITLE     Colonizing and infecting subclones diverge during Staphylococcus
            aureus infection
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 18320)
  AUTHORS   Chako,K.I., Sullivan,M.J. and van Bakel,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-AUG-2018) Genetics and Genomic Sciences, Icahn School
            of Medicine, One Gustave L. Levy Place Box 1498, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2017
            Assembly Method                   :: HGAP v. 2.2.0
            Expected Final Version            :: yes
            Genome Coverage                   :: 28.7981151681x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003425545.1-RS_2024_05_15
            Annotation Date                   :: 05/15/2024 01:44:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,917
            CDSs (total)                      :: 2,835
            Genes (coding)                    :: 2,762
            CDSs (with protein)               :: 2,762
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 73
            CDSs (without protein)            :: 73
            Pseudo Genes (ambiguous residues) :: 0 of 73
            Pseudo Genes (frameshifted)       :: 40 of 73
            Pseudo Genes (incomplete)         :: 35 of 73
            Pseudo Genes (internal stop)      :: 11 of 73
            Pseudo Genes (multiple problems)  :: 13 of 73
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031668.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..18320
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="199"
                     /isolation_source="nares"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pPS00120.1A.1"
                     /geo_loc_name="Germany"
                     /lat_lon="51.9636 N 7.6132 E"
                     /collection_date="1994"
                     /collected_by="University of Munster"
     gene            join(18320,1..551)
                     /locus_tag="DD546_RS15095"
     CDS             join(18320,1..551)
                     /locus_tag="DD546_RS15095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002508689.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_050956587.1"
                     /translation="MAKIGYARVSTQDQSLDGQIDTLEEYGCERIFSEKASGRKTKRTE
                     LDKCLDYLREGDILVIYKLDRLGRTTKQLIELSQWLDDNSIDLHIINMNVSTKDAMGKM
                     FFTMMSAFAELEANLLSERTKKGLEAARARGRKGGRPSLPDHKKREIKFLYDEQKLTGE
                     DIAKQTGVSRSTVYRIIKMK"
                     /name="recombinase family protein"
     gene            complement(698..1372)
                     /locus_tag="DD546_RS15100"
                     /old_locus_tag="DD546_00002"
     CDS             complement(698..1372)
                     /locus_tag="DD546_RS15100"
                     /old_locus_tag="DD546_00002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001106019.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRGRGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMAKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(<1428..1646)
                     /locus_tag="DD546_RS15105"
                     /old_locus_tag="DD546_00003"
                     /pseudo=""
     CDS             complement(<1428..1646)
                     /locus_tag="DD546_RS15105"
                     /old_locus_tag="DD546_00003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010889940.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid recombination protein"
                     /name="plasmid recombination protein"
     gene            complement(1832..3211)
                     /gene="tet(K)"
                     /locus_tag="DD546_RS15110"
                     /old_locus_tag="DD546_00004"
     ARG             complement(1836..3211)
                     /name="tet(K)"
                     /gene="tet(K)"
                     /gene_name="tetracycline efflux MFS transporter Tet(K)"
                     /tool="amrfinderplus"
                     /drug_class="TETRACYCLINE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(3373..4317)
                     /locus_tag="DD546_RS15115"
                     /old_locus_tag="DD546_00005"
     CDS             complement(3373..4317)
                     /locus_tag="DD546_RS15115"
                     /old_locus_tag="DD546_00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000277654.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003916 - DNA topoisomerase activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation factor domain-containing
                     protein"
                     /protein_id="WP_000277654.1"
                     /translation="MYKNNHANHSNHLENHDLDNFSKTGYSNSRLDAHTVCISDPKLSF
                     DAMTIVGNLNRDNAQALSKFMSVEPQIRLWDILQTKFKAKALQEKVYIEYDKVKADSWD
                     RRNMRIEFNPNKLTRDEMIWLKQNIISYMEDDGFTRLDLAFDFEDDLSDYYAMSDKAVK
                     KTIFYGRNGKPETKYFGVRDSNRFIRIYNKKQERKDNADAEVMSEHLWRVEIELKRDMV
                     DYWNDCFSDLHILQPDWKTIQRTADRAIVFMLLSDEEEWGKLHRNSRTKYKNLIKEISP
                     VDLTDLMKSTLKANEKQLQKQIDFWQHEFKFWK"
                     /name="replication initiation factor domain-containing
                     protein"
     gene            complement(4474..5148)
                     /locus_tag="DD546_RS15120"
                     /old_locus_tag="DD546_00006"
     CDS             complement(4474..5148)
                     /locus_tag="DD546_RS15120"
                     /old_locus_tag="DD546_00006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001106022.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRGRGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(5178..6335)
                     /locus_tag="DD546_RS15125"
                     /old_locus_tag="DD546_00007"
     CDS             complement(5178..6335)
                     /locus_tag="DD546_RS15125"
                     /old_locus_tag="DD546_00007"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="PHP domain-containing protein"
                     /protein_id="WP_050956586.1"
                     /translation="MDKGSEWIRWDLHVHTRSSEDYKYMHDDAEEKLVEEWKKQGIKAV
                     AITDHFTIDSDRINKLRELAKGEITIFPGVELRTDKGSTNIHVIGIFSEHKNLKELQND
                     FEAIMLRRNPNKDKFEKIFWDFNDIEKFIRDRQGIITIHAGNKSNSIEEISNDSAFNMA
                     IKESYSHKVDIFEHNNTHSCKGYEKSVFKVTGIKPQIVCSDNHNPLDYQYSDKLWIKSQ
                     PTFKGLLQAIKHPTERIYIGPEPQKIKHEKFNKQYIIEEIEICKNKNSSTYDMWFDTKI
                     PLNSSLTAIIGNKGSGKSALSDIIALTGESDKVDENNASFLNNKRFNKSPQKYGDNYES
                     TLTWKDKHENKTNSLMLKKSDNYNNYVQYLPQKYIEKGSVAKLNL"
                     /name="PHP domain-containing protein"
     gene            complement(6513..6608)
                     /locus_tag="DD546_RS15130"
     CDS             complement(6513..6608)
                     /locus_tag="DD546_RS15130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_000889979.1"
                     /translation="MLEILVHITTTVISGCIVALFTHWLRNRNDK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(6903..7388)
                     /locus_tag="DD546_RS15135"
                     /old_locus_tag="DD546_00008"
     CDS             complement(6903..7388)
                     /locus_tag="DD546_RS15135"
                     /old_locus_tag="DD546_00008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002455937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_050956585.1"
                     /translation="MKKFSKIVLASGIVLGFSVTPELFNATEAQAQESIEPYYSYDGYT
                     AYQSGFILDKNFKESLKYDNFTINGYQISKNQTGNNRINLYDQTLYGVSENKANGVFFS
                     LDGKSINKNTLIQNYGQPNSYSPTSAWGEEYMYKIGNKDVRFYIYNGYVIKCQIISE"
                     /name="hypothetical protein"
     gene            complement(8476..8658)
                     /locus_tag="DD546_RS15390"
     CDS             complement(8476..8658)
                     /locus_tag="DD546_RS15390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002500874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_050956584.1"
                     /translation="MKIFLYFIYFFVSFFIFKSLFDLVIPAIDFHLYLNLISALFFGLF
                     MTLLDFVLKKNKNKK"
                     /name="hypothetical protein"
     gene            complement(8802..9476)
                     /locus_tag="DD546_RS15150"
                     /old_locus_tag="DD546_00010"
     CDS             complement(8802..9476)
                     /locus_tag="DD546_RS15150"
                     /old_locus_tag="DD546_00010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105994.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKVAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            9609..10166
                     /locus_tag="DD546_RS15155"
                     /old_locus_tag="DD546_00011"
     CDS             9609..10166
                     /locus_tag="DD546_RS15155"
                     /old_locus_tag="DD546_00011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016425720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_050956596.1"
                     /translation="MYNINSSKIIKGSLAFVIASGVVFSPVGIDNDSEAAEANSSMVSK
                     KSAGTISKINDNVARIDLNKGITYNVDENGIATIKDTHSGKTEQLPVTAKDKNGEDATL
                     VYFEEDGKLGVQVVKQQQERGAAKCVIGTVGGAIGGATTGGLGGAAVGTVTLPIVGTVS
                     GGVVGTIGGGIGGASGGYVAGC"
                     /name="hypothetical protein"
     gene            complement(10641..10742)
                     /locus_tag="DD546_RS15160"
     CDS             complement(10641..10742)
                     /locus_tag="DD546_RS15160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_000228874.1"
                     /translation="MVEALVHITTTVISGCIVALFTHWLRTRNNKKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(10904..11251)
                     /locus_tag="DD546_RS15165"
                     /old_locus_tag="DD546_00012"
     CDS             complement(10904..11251)
                     /locus_tag="DD546_RS15165"
                     /old_locus_tag="DD546_00012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_050956595.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSIASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNQEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(11270..11887)
                     /gene="cadD"
                     /locus_tag="DD546_RS15170"
                     /old_locus_tag="DD546_00013"
     ARG             complement(11274..11887)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="99.51"
                     /coverage="100.0"
     gene            complement(13155..13484)
                     /locus_tag="DD546_RS15180"
     CDS             complement(13155..13484)
                     /locus_tag="DD546_RS15180"
                     /inference="COORDINATES: protein motif:HMM:NF013603.4"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /protein_id="WP_307833771.1"
                     /translation="MISLINNSNDFITLKKTSKYSVKSSDFLTDDDEKNQEILSDLKKG
                     LYRKRMLSYGGLLKQKHKILNLDDAEDGNLINTSDEDKTTDEEEKAHSITAIWNFEKQN
                     YYLRH"
                     /name="protein rep"
     gene            complement(13465..14409)
                     /locus_tag="DD546_RS15185"
                     /old_locus_tag="DD546_00015"
     CDS             complement(13465..14409)
                     /locus_tag="DD546_RS15185"
                     /old_locus_tag="DD546_00015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_031903320.1"
                     /translation="MPNFEKYNLSQVKTERFYQLPKYLFEDAYFKKMSAEAKIMYALLK
                     DRFELSIQNEWVDRNNNIYFIFSNKHLCEYLGYAEQKIIKLKKELVNFNLLTQERVGLN
                     KPNRLYLLKPNYDIEASLTKELPNSQFQNNEFGSSRTVNLSGQELPNSQSNDTELNNTN
                     YIENEDNDTYDMNDIISNALINNNHHSNHTNHQKTEFNNDALKFQVLEELPQQLQDYLS
                     KFEIREIRIIKSVLLKGKKSFNTSHNTYYRLEDVEFEIVSVLKRFKAMLLQKNETVEAM
                     QGYLMQSIKAELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            14854..15624
                     /locus_tag="DD546_RS15190"
                     /old_locus_tag="DD546_00016"
     CDS             14854..15624
                     /locus_tag="DD546_RS15190"
                     /old_locus_tag="DD546_00016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_050956590.1"
                     /translation="MKTIKMVADELNVTKQTIVNNAKSLNISFEKENGINYINDNDCLK
                     IIEKITKKERTMQKKESIKKERFNENTAEFEKHIYNNSNSFESLKTKVNELEKQIEIFE
                     TRAKNDEKYIENLTKQLDQQNSNVNTLNKLLENQQILALESNKKIQKLENQLEEERQLN
                     YSFDTATNDRENINPQEATFTEEYQNINQQQKKIQPIEPELNHKGITEAKNDDSANEDV
                     LKREDKLSEEIESGPEDREVETPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(15689..17011)
                     /locus_tag="DD546_RS15195"
                     /old_locus_tag="DD546_00017"
     CDS             complement(15689..17011)
                     /locus_tag="DD546_RS15195"
                     /old_locus_tag="DD546_00017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001281642.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="WP_050956589.1"
                     /translation="MSDLLLLPDLKTIEPPQENESDMMFKVEATFPPVRCPQCGFDRLY
                     KHTSRKQLIMDLPIRLKRVGLQLNRRRYKCRECGTTFWERLISIDEKRSMTKRLIRSIE
                     EQSLSKTFVDVAESVGVDEKTVRNIFKDYVALKEREYQFETPKWLGIDEIHIIKKPRLV
                     LTNVERRTIYDIKPNRNKDTVIQRLSEIKDNTYIEYVTMDMWKSYKDAVNTVIPHAKVV
                     VDKFHVVRMANQALDSVRKSLKANMTAKESRTLMRERYILLKRKHDLNERDSFLLDTWL
                     SNLPELKEAYELKEEFYLIWDTDDLEQAKDRYRYWRQCCLSSNSKNAYKDLLRAVDNWQ
                     DEIFNYFDKRLTNAYTESINSIIRQVERMGRGYSFEALRAKIIFNEKLHKKRKPRFNSS
                     AFSKAMLYDSFNSYQITDRDKTGNYGVDFSTLIKKLEKSNL"
                     /name="ISL3 family transposase"
     gene            complement(17375..17719)
                     /locus_tag="DD546_RS15205"
                     /old_locus_tag="DD546_00019"
     CDS             complement(17375..17719)
                     /locus_tag="DD546_RS15205"
                     /old_locus_tag="DD546_00019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002485687.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_050963111.1"
                     /translation="MSENWCIPKPKLTERPLLDTEDAEGLSETFKILSNGTRLRILHTL
                     LRTPNASVSEVAEQLEMKPQAISNQLQRLVDKGIVRSIREANFIRYRIVDNCVVSLLDR
                     GWCLTEDLPK"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     Typing          complement(3374..4317)
                     /name="rep_cluster_1118"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(13158..13334)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="93.82"
                     /coverage="94.0"
                     /evalue="1.33e-69"
     Typing          complement(13466..14409)
                     /name="rep_cluster_1215"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="98.519"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 tggctaaaat tggttatgca cgtgtatcaa cgcaagatca aagtcttgat ggacagattg
       61 atacacttga ggaatatggt tgtgaacgta tctttagcga gaaagcgagt ggtcgcaaaa
      121 cgaaacgaac ggaacttgat aaatgcttag attatttacg tgaaggcgat attttagtta
      181 tctataaact agatcgtctt ggccgaacaa ccaagcaatt aattgagtta tctcaatggt
      241 tagatgataa tagtattgat ttacatatta taaatatgaa cgtatcaacc aaagatgcga
      301 tgggcaagat gttctttact atgatgagtg catttgctga acttgaagct aacttattaa
      361 gtgaacgtac gaaaaaagga ttagaagcag caagagctag agggagaaaa ggtggaagac
      421 catcattacc agatcataaa aaaagagaga ttaaattctt atatgatgag caaaaactta
      481 ctggcgaaga tattgctaaa caaacaggag tgagtcgttc tactgtatat agaataataa
      541 aaatgaagta gtaaaaacaa ataatcacag gaagaaaact aatgaaagga gaatctctaa
      601 tttgaagatt ctcctttcat tagtttttat aacctatatg gttctgttgc aaagtaaaaa
      661 atatagctaa ccactaattt atcatgtcag tgttcgctta acttgctagc atgatgctaa
      721 tttcgtggca tggcgaaaat ccgtagatct gaagagacct gcggttcttt ttatatagag
      781 cgtaaataca ttcaatacct tttaaagtat tctttgctgt attgatactt tgataccttg
      841 tctttcttac tttaatatga cggtgatctt gctcaatgag gttattcaga tatttcgatg
      901 tacaatggca gtcaggttta agtttaaaag ctttaattac tttagccatt gctaccttcg
      961 ttgaaggtgc ctgatctgta attacctttt gaggtttacc aaattgttta atgagacgtt
     1021 taataaacgc atatgctgaa tgattatctc gttgcttacg caaccaaata tctaatgtat
     1081 gtccctctgc atcaatggca cgatataaat agctccattt tccttttatt ttgatgtacg
     1141 tctcatcaat acgccatttg taataagctt ttttatgctt tttcttccaa atttgatata
     1201 aaattggggc atattcttga acccaacggt agaccgttga atgatgaacg tttacaccac
     1261 gtccccttaa tatttcagat atatcacgat aactcaatgc atatcttaga tagtagccaa
     1321 cggctacagt gataacatcc ttgttaaatt gtttatatct gaaatagttc atacagaaga
     1381 ctcctttttg ttaaaattat actataaatt caactttgca acagaaccat ttttcttttg
     1441 cctgtataat tctgttcgat tttttcatca atcaagttat taaaattctg tttattagca
     1501 tttaccaaat cataatttaa gtaagtttta ctatggtcta tatcttcatt ttcataatta
     1561 ttattttctc tttgaacatg tttttgtatg cccgttgtat ttgttccaga tttaactttt
     1621 gaaactctaa caatggaata agacatataa aaatcactcc taagcacaaa ggtttcatgt
     1681 gtatttaata gtttaagtct aacacactag acttattttt aataagtcgt taatacgtgt
     1741 gctctgcgag gcttaaacct gtttttgcta acgcaaaaaa tgagtggcaa aatgctagcc
     1801 actcatagtt ctaaaccaaa atataatata actattcaaa ctgcttttca gaacgtttaa
     1861 atacaataat cgtcaaaaga caacataaaa taataaggat agccatggct acaagaatat
     1921 tactatacac tccagaagaa taatttataa attccagaac tagtttacga ttaatcaatt
     1981 gtagtgacaa taaacctcct acaattgcta tacctgttcc ctctgataaa aaacttgtga
     2041 aatttagcaa actcattcca gaagcaactt cttcttcaga aagactactt gatactattt
     2101 ttgatataac tgttttagta aaagataatc cgcccataac aaatataaac ataaaagtag
     2161 tcaaccacat actaaactca acaaaaaatg caatagttaa aaaacttata gagatagaca
     2221 atgatcctaa aataaaaaca aataatgatc cttttctatc cactaaaaaa ccaccaaaat
     2281 aaccaaaaac aataacactc atggttccag gaaaaataac actattacct attgtcgcta
     2341 catttacatg ataaatagtt ttcatcatat aaggcaccat tgatataaaa ccagctacta
     2401 tagaaaatat tagcccacca gaaaacaaac caagcataaa cggaatgttt ttccctagtt
     2461 taggattaat aaaagggtta gaaactcttg aaatatgttt aataaaaatc acaaaaaaga
     2521 ttgtgaagag tattaaaaaa gtccaattat aatttgtcgt aaataacata aaacatataa
     2581 tacttataga cattaaaaca atacctacga tatctaatgt attttttgtt gatttaccag
     2641 gtaccattac tttaataaga aaaggtatag ttactattgt aatcatagga agtataagta
     2701 ggtaagacca atgaatataa tgtgctatta ttccccctat tgaaggacct aacccttcac
     2761 ctaaagctac aattgatcct ataaaaccaa aggctttgcc ttgttttttt cttgtaatat
     2821 ttctagctac aaccaccata atcagtgaag ggaatgcagc agatcctact ccttgtacta
     2881 acctaccaaa aatcaaaata aaaaagtgat tgtgaccaat aaaagcaatc aatgaaccaa
     2941 gacagctcaa actaatacca ataattaaca atttttttat atttatataa tcagataatt
     3001 ttccatatac tgctgttcct atcgaaaaag ttaacatata tgcagtgttt acccagtttg
     3061 taattccagg agtagtatta aaatgatttg caatatcagg taaagaaaca tttaaaacca
     3121 tttcatttaa tacactaaaa aatgaaagaa tacaaagcca aaataaaacg ctataaaaca
     3181 aacctttaaa ttttttatat aaactaaaca attttacctc tttacttgag gtgactaaag
     3241 tttatagggg taaattattc tttcacctca tataaattcc ccaaattttt aaatagacac
     3301 ttcataaaaa aatcctccta aattagaata gtttaaatat atcatttttg ttcagtaata
     3361 ttaatatgta cactatttcc aaaatttaaa ttcatgttgc caaaaatcga tttgtttttg
     3421 caattgtttt tcgttcgctt ttaaagtcga tttcattaag tccgttaaat cgactggcga
     3481 aatttctttt atcaaattct tatattttgt tctagaattt ctgtgaagct ttccccattc
     3541 ttcttcatca ctcaataaca taaaaactat tgctctatcc gcagtgcgtt ggatagtttt
     3601 ccaatctggt tgcaagatat gtaaatcact aaagcaatca ttccagtaat ccaccatatc
     3661 tcttttaagt tcgatttcta cacgccataa atgttcagac ataacttcag catctgcatt
     3721 atctttacgt tcttgctttt tattataaat tctaataaat ctattactat ctctcacgcc
     3781 aaaatatttt gtttctggct taccattacg accataaaaa atagttttct taactgcttt
     3841 atcagacatt gcatagtagt cactcaaatc atcttcaaaa tcaaaggcta aatctaatct
     3901 tgtaaaaccg tcatcttcca tgtagcttat tatattttgt tttaaccaaa tcatttcatc
     3961 tcgtgtaagt ttgtttggat taaattcaat acgcatatta cgtctatccc aactatctgc
     4021 tttcactttg tcatattcaa tataaacttt ttcttgaagt gctttagctt taaactttgt
     4081 ttgaagaata tcccaaagtc ttatttgggg ctctacactc ataaatttag aaagggcttg
     4141 agcgttgtct cggttgagat ttccaacgat cgtcattgca tcaaaactta attttggatc
     4201 agatatgcac acagtatgtg cgtccaaccg gctattagag tagccggttt tagaaaaatt
     4261 gtctaaatcg tgattttcca aatgatttga atgatttgca tgattgtttt tatacataaa
     4321 aaatcgactc cttaatctca atttcgttta aggaatcgct cacccaaata tatatcttga
     4381 tgtatattta aatatcgttt aatatctaaa tataggttct gttgcaaagt aaaaaaatat
     4441 agctaaccac taatttatca tgtcagtgtt cgcttaactt gctagcatga tgctaatttc
     4501 gtggcatggc gaaaatccgt agatctgaag agacctgcgg ttctttttat atagagcgta
     4561 aatacactca atacctttta aagtattctt tgctgtattg atactttgat accttgtctt
     4621 tcttacttta atatgacggt gatcttgctc aatgaggtta ttcagatatt tcgatgtaca
     4681 atggcagtca ggtttaagtt taaaagcttt aattacttta accattgcta ccttcgttga
     4741 aggtgcctga tctgtaatta ccttttgagg tttaccaaat tgtttaatga gacgtttgat
     4801 aaacgcatat gctgaatgat tatctcgttg cttacgcaac caaatatcta atgtatgtcc
     4861 ctctgcatca atggcacgat ataaatagct ccattttcct tttattttga tgtacgtctc
     4921 atcaatacgc catttgtaat aagctttttt atgctttttc ttccaaattt gatataaaat
     4981 tggggcatat tcttgaaccc aacggtagac cgttgaatga tgaacgttta caccacgtcc
     5041 ccttaatatt tcagatatat cacgataact caatgcatat cttagatagt agccaacggc
     5101 tacagtgata acatccttgt taaattgttt atatctgaaa tagttcatac agaagactcc
     5161 tttttgttaa aattatacta taaattcaac tttgcaacag aacctttttc tatatacttt
     5221 tgcggtaaat actgtacata attattataa ttgtctgatt ttttaagcat tagactattg
     5281 gttttatttt catgtttatc tttccacgtt aatgttgatt catagttatc tccatatttt
     5341 tgtggtgact tattaaatct cttattgttt aaaaaagaag cattattttc atcaacttta
     5401 tctgattctc cggttaatgc tataatatcg gataatgcgc tcttcccact acctttatta
     5461 ccgataatag ctgttaaact tgaatttaat gggatttttg tgtcgaacca catatcataa
     5521 gttgaagaat ttttattttt acaaatctct atttcttcta taatatattg tttattaaat
     5581 ttttcatgtt taattttttg tggttctgga ccaatatata tacgctctgt cggatgcttt
     5641 atagcttgta ataaaccttt aaatgtaggc tgagacttta tccataactt atctgagtat
     5701 tgataatcta atggattatg attatcagaa caaacaattt gaggttttat accagtaact
     5761 ttaaatacac ttttttcata acccttacac gaatgagtat tgttatgctc aaatatatca
     5821 actttatgac tataagattc tttaattgcc atattaaatg cgctgtcatt acttatttct
     5881 tctatactat ttgacttatt accggcgtgt attgtaatta taccttgtct atctcttata
     5941 aatttttcaa tatcattaaa atcccaaaat atcttttcaa atttatcttt atttggattt
     6001 cttctaagca ttatagcttc aaaatcattt tgaagctctt ttaaattttt atgctcagaa
     6061 aatattccaa ttacatgaat attagtagat cctttatctg tccttaattc tactccagga
     6121 aaaattgtta tttctccttt agctaactct cttaatttat taattctatc tgagtctata
     6181 gtaaaatgat ctgttattgc tactgcttta attccttgtt ttttccactc ttccactaac
     6241 ttttcttcag cgtcatcatg catatattta taatcttctg acgaacgagt gtgaacatgc
     6301 aaatcccatc gaatccactc tgatccttta tccatttgta ttgtctcctt ttttgtttat
     6361 attatacttt aatttaaatt taattatatg ttattttgca ttcctctatt aaccagtgtt
     6421 ataatgtgat taacaagaat tctagcgtga atacaccaat cccctcacta ttgcagtagt
     6481 gaggggattt ttttaggtgt ggctatagtc gcctatttat cgttgcgatt acgtagccaa
     6541 tgcgtaaata acgcaacaat acaaccactg atgactgtgg tcgtgatgtg aacaagaatt
     6601 tctagcatga ataacacctc ctctctgcgt ctaagtttga cgcctgagag ataggcgact
     6661 ctattattat atcatctgtg aatatacaaa catatctact tccgataagt cgtcttatgt
     6721 tatataactt tgttttttat agtatcaaga caagaagatc atcctccaaa aaaagagatt
     6781 aaacaaccta aggttgctta atctcaatat ttggactcat cagtccgatt tgacgtagag
     6841 ccataaaaaa acgtgaagta agtgaacttg caacttacct cacgttttat acctaaactg
     6901 tcttattcac ttataatttg acatttaatc acatagccat tgtaaatata aaatctgaca
     6961 tctttattac caattttgta catatattct tcaccccatg ctgaagtagg agagtaagaa
     7021 tttggttggc cataattttg aattaaagta tttttattaa tagattttcc atcgagagag
     7081 aagaaaacac cgttagcttt attctcagac acaccataaa gggtttgatc gtataaattt
     7141 attcgattgt tacctgtttg attttttgat atttgatagc cgttgatagt aaaattgtcg
     7201 tatttcaatg actctttgaa atttttgtct aatataaatc cactttgata cgcagtataa
     7261 ccatcataac tataataagg ttcaatagac tcttgcgcct gtgcttccgt tgcattaaat
     7321 agttcgggcg ttacagagaa acccaaaaca ataccgctag ctagaacaat tttagaaaat
     7381 ttcttcataa aaaccctcct aattatttat aattcatcta taattattac agaaatgtaa
     7441 caaaaagtca tccggattac aaaaatatta caaaaaattc atctttttta gaaaatgcaa
     7501 tttgtcatac tttccattct attttatttc tttaaacagt ttaaaataaa taatactttg
     7561 cttttcattt aacattttat agttaattaa aatagtctta actgaaagtg aaaaacaaga
     7621 aattaatcat caaatgattg atgaaattga agaagaaaat tgaaaataaa atttggtatt
     7681 tttcttaaac gttagcaaaa aagctagcgt ttttttgttt aaaatagttc aaaaatgtct
     7741 gggtacaaac ggggtacaag gaaagtaaaa tggtataaaa ggtaaaacgc ttgtatccct
     7801 tgaaatgtct ggcttcgcca gacctaccat ttttaaatgg tagcagattt cccttatgct
     7861 cttacaaaga atttggagcc aattcaaaat tttggtgttt taaaagaaaa aatgcctctg
     7921 caagaactaa aaaacagaac tactttttga atgattttat gccaattttt aatttgcata
     7981 taactgggca gtgtgtaaaa aatcgacact ggttaagtaa aaaatttagg tttgtctttc
     8041 tgatttttaa atttagttca tactttcgtt ttaagagcca ttaaatagct ttaggtaaaa
     8101 taatatataa aatacctttt atggaggtgt cagaatgaaa aaaccttcta ttttggcagg
     8161 aataataatc ctactactta taatttgcag tatagtattg aacttaatca atattcccag
     8221 tgaagccaat atcgcatact caataacagc cattataatt attatcttat tgttctttat
     8281 tattcctaaa aataacaaat tataatattg ctttattcca attgctttat tgacgttgag
     8341 cctcggaacc cttaacaatc ccaaaacttg tcgaatggtc ggattaatag ctcacgctat
     8401 gccgacattc gtcttcaagt ttagttaagg gttcttctca acgcacaata aattttctcg
     8461 gcataaatgc gtgttctatt tcttgttttt attctttttt aatacaaaat cgagtagtgt
     8521 cataaaaagt ccaaaaaata atgcagatat caggttcaaa tatagatgaa aatcaattgc
     8581 tggtattact aaatcaaata aagatttaaa aataaaaaac gaaacaaaaa agtatataaa
     8641 atataaaaag attttcaaaa caaaaccacc tctccgaaaa atctatcaca ctaaatccca
     8701 aagtttaaaa tacctttttt tgcaatttta agatactttt tagggttctg ttgcaaagta
     8761 aaaaatatag ctaaccacta atatatcatg tcagtgttcg tttaacttgc tagcatgatg
     8821 ctaatttcgt ggcatgggga aaatccatag atctgaagag atctacggtt ctttttatat
     8881 agagcgtaaa tacattcaat accttttaaa gtattctttg ccgtattgat actttgatat
     8941 cttgtctttc ttactttaat atgacggtga tcttgctcaa tgaggttatt cagatatttc
     9001 gatgtacaat gacagtcagg tttaagttta aaagctttaa ttattttagc cattgctacc
     9061 ttcgttgaag gtgcctgatc tgtaactacc ttttgaggtt taccaaattg tttaatgaga
     9121 cgtttgataa acgcatatgc tgaatgatta tctcgttgct tacgcaacca aatatctaat
     9181 gtatgtccct ctgtatcaat ggcacgatat aaatagctcc attttccttt tattttgatg
     9241 tacgtctcat caatacgcca tttgtaataa gcttttttat gctttttctt ccaaatttga
     9301 tataaaattg gtgcatattc ttgaacccaa cggtagaccg ttgaatgatg aacgtttaca
     9361 ccacgttccc ttaatatttc agatatatca cgataactca atgcatatct tagatagtag
     9421 ccaacggcta cagtgataac atccttgtta aattgtttat atctgaaata gttcatacag
     9481 aagactcctt tttgttaaaa ttatattata aattcaactt tgcaacagaa ccagcaaaaa
     9541 tatgatatgt tatatattgg gatgtttatt aagggattgt ttaaattctg aaataaggag
     9601 tttttacaat gtacaatatt aatagttcaa aaattataaa aggttctctt gcatttgtca
     9661 tcgcttctgg agttgtattt agccctgttg gcatcgacaa tgattctgaa gctgctgaag
     9721 ctaattcatc aatggtttct aaaaaaagtg ctgggacaat ttcaaaaatt aatgataacg
     9781 tggctagaat tgatttgaac aaagggatta catacaatgt tgatgaaaat ggtatagcta
     9841 cgataaaaga tactcattct ggaaaaactg agcaattacc tgtaacagca aaagataaaa
     9901 atggcgaaga cgcgacttta gtttattttg aagaggatgg taagttgggt gttcaagttg
     9961 ttaagcagca acaagaaaga ggagctgcta aatgtgtaat cggaactgta ggaggagcta
    10021 ttggtggtgc gacaactggt ggcttaggag gggctgctgt tggtactgtt acacttccta
    10081 ttgttggaac tgttagtggt ggtgttgtag gaactatcgg tggcggtatt ggcggtgctt
    10141 ctggcggata tgtagctggt tgttaaaagg tgggataact atgtatgata gaaaaatctt
    10201 caactggcca atatttttta ttgtgatttt gagttatgta tttatgttat cgttgttttt
    10261 atgggtttct aatataagtc atttaaaagt ctttttattg actattcctt ttcttttaat
    10321 gacttgtgtt tatataatac tgtttataaa aaatagatag ttagttttta cacgtgttta
    10381 tgtatttcat aagcacgtgt atttatgtat ttttggaaac gagtgtaacg agtttcttct
    10441 ggttctgttg caaagaaaaa gattgttaga aatcctataa aactctctat tttatttcat
    10501 cctcctatat agatactaat tttgcattct tctactaacc agtgttataa tttagacaac
    10561 aagagcttcg tacattatat gcaccaatcc cctcactact cgcaatagtg aggggatttt
    10621 taggtgttgg ctaatatcgc ctattttttc ttattgttac gtgtacgtag ccaatgcgta
    10681 aataacgcaa caatacaacc actgatgact gtggtcgtga tgtgaacaag agcttcgacc
    10741 atctgatatg cacctcctct ctgcgtctaa attgacgcct gagagatagg cgacctgtat
    10801 attatatcat ctctgaataa gggataatag ataacttccg ataagtgatt ttatgttata
    10861 tctttgctta tttttatagt atcaagacag gaagaaactc gtttcaaaaa ccctcctgat
    10921 ttttagagaa aaactctctt atttcatcgt ctttaataaa ataatatgcc atctttccat
    10981 ctttataaaa atcaagcacc tcatttttat ataaaagtct taaatgatgt gaagttgaag
    11041 caatactcat tttcaatatc aaagaaatat cacaaacaca caactcatct tctttaatca
    11101 aagataatat gattttcaat tttttctcat cacaaatttt ttctaaaatg ttaagtaatt
    11161 tcttagattt atcatcttct aaaaaactta aagcattgtt aactttatcc tcatgtacac
    11221 agatcacatc acaagtattt tcataactca tataaaatca caccctaaat taaaatataa
    11281 atcctaaaat tgtttgaata gtgtcatttt caataataat aaataaacct aaagctatat
    11341 aaatgatagc cataatccaa cgactaaatt tctcaacaat ttctccaatt cctgggatat
    11401 tagctaattt ttgtgcagta aacaccaaga agaaaattaa aattaaaaag acaaacagag
    11461 taagtaataa attagtaaca cttaatgtca caaaatacgg aacaaataaa ccaatattat
    11521 cggcgccaca acttgctatc gtaacaattg caaccgtacc aactaattta gacaatcctt
    11581 tttcattcaa ttctttttta gctctctttt ctccttcaca atcatcataa atagccactt
    11641 taattccaag ataaattggt attaaaccca ataaacctaa tatccacttt tctggaacat
    11701 aatttaatac aaaagctaaa aacaaactaa ctaatattaa aataatagac cctaaatatt
    11761 gaccaacata aatatttcta tattcttttc tagtctttgc tctagcaaaa aatattaata
    11821 aaattactaa taaatcaact gctgtagcaa tataaagaac agcagcagca acaaccgttt
    11881 gaatcataat acacctcatt caaaaatatt tttgaatgta ttataactta tatttttaaa
    11941 taatcatagg tgctttattc caattgcttt attgacgttg agcctcggaa cccttaacaa
    12001 tcccaaaact tgtcgaatgg tcggcttaat agctcacgct atgccgacat tcgtctgcaa
    12061 gtttagttaa gggttcttct caacgcacaa taaattttct cggcataaat gcgtgtctat
    12121 gcgtagacat ggagacactt cagaattatg gagtgattac atgagtttaa ctatttttct
    12181 ttattcagtt ttaggaagtt tattagcaaa ttatatctac gaaaaatctt caaaataaat
    12241 aactttttcg gttctacttt gtacacttta tctacctggt agacctaatt gttattgctt
    12301 tacaggtcta aaattcgtcg ttataatcta gttaaatccc gtaagggcgc acttatacgt
    12361 cggataaatc gacatgtgca aaaacgtaat cgaccttcgt cgattttttt atttcaaaat
    12421 taaagaaacg gcttgagata ttccgagcag ttataaaaat taatttgcgt tgaatattgc
    12481 tactacattc ttgaaaaagt gatgtagatt tatagcccat aacttttttg aattacatcg
    12541 acgatacggc gtcgaaagaa aaataaatag accgtatgaa agaaaaagct acctcacttt
    12601 atctggggga gcttttattt tttatgccct tattttgaat tttaagaggg cattttaaag
    12661 atttaggggt gattcatata gttttatatc taaaacttat atacgctttt aaaacgcaaa
    12721 tatgagccaa ataaatatat gctattttca aaaacaaaaa tttgagcaaa aacaataact
    12781 atttttagac actgcccatt tacatgcaaa ttaaaaatta gcataaaata ctttaaaact
    12841 tccccatgtt tttctaaatt cctgcagggc ttttcttatc aaaaacttag aaattttaat
    12901 ttaactctaa aatctccgta agtaagagca taagggaaat atgaccccat ctatagatga
    12961 ggtatctggc aaagccagat atttcaagac ttcgtcggtc tttttgcatg ggggcataaa
    13021 aagacgaaat gtcacacttt tgtgacacaa tatattgagt ttgtcacagt tttgtgacac
    13081 tacatacagc atttgtcaca aaaataagac agtacttttt tacaaaaaat caataaaaaa
    13141 gacatcagtt atcactaatg tcttaaataa taattttgtt tttcgaaatt ccaaattgcc
    13201 gtaattgaat gtgctttttc ttcttcgtct gtcgttttat cttcatcact tgtattaatc
    13261 aaattaccat cttcggcatc gtctaagttt aaaattttat gcttttgttt cagcaatcca
    13321 ccataactta acatacgttt tcgatacaaa ccttttttta aatcacttaa aatttcttga
    13381 tttttttcgt catcatcagt taaaaagtca gatgatttaa cggaatattt tgatgtcttt
    13441 ttgagtgtta taaaatcatt tgaattattg attaaagata ttatattgtt tcatgttttt
    13501 acggcgcata taaagggcat gtgtttcttc aagttcagct ttaatggatt gcattaaata
    13561 accttgcata gcttcaacgg tttcattctt ttgtagcaac attgctttaa aacgtttcaa
    13621 tacacttaca atttcaaatt caacatcttc taaacgataa taagtattat gtgaagtatt
    13681 aaatgacttt ttccctttga gtaatacact tttaataatc cgaatttctc taatttcaaa
    13741 tttacttaaa tagtcttgaa gttgttgtgg caattcttcg agtacttgga acttaagagc
    13801 gtcattatta aattcagttt tttgatgatt tgtatgattt gaatgatgat tattatttat
    13861 taaagcatta gatataatat cattcatatc atacgtatca ttatcctcat tctctatata
    13921 attagtatta tttaactcag tatcattaga ctgtgaattt ggaagttctt gaccacttaa
    13981 attcacagtt ctagaacttc caaattcatt gttctggaac tgtgaatttg gaagttcctt
    14041 ggtaagactt gcttcaatat cataatttgg ttttaataaa tataatctat ttggtttatt
    14101 gaggccaaca cgctcttgag ttaataaatt aaaatttact aactcttttt tcaattttat
    14161 gattttttgt tctgcataac ctaagtactc gcacaaatgt ttattactga aaataaagta
    14221 aatgttatta tttctatcta cccattcatt ttggatggat aattcgaaac gatcttttaa
    14281 taatgcatac ataattttgg cttctgctga cattttctta aaatatgcat cttcgaacaa
    14341 atatttaggc aattggtaaa atctttcagt ttttacttgt gataaattgt atttctcaaa
    14401 attgggcata ataaaaacct catttccact ttttggatag aggtaataaa acaattttta
    14461 cgtaggttat atgttttgtg cttgcactta tatgattaga tatatataat acaagtatca
    14521 aaaaattata taaacagacg aatgcgaatc gttttattac cgagagtcga tgctacgcca
    14581 atagtatcga ctcttttaat attcacaaag taatattaac acttttaaga ttgtatataa
    14641 agctttttaa gtttagttaa aagaacgttg taactttaaa atgataaaaa ctcactactt
    14701 tagcacctaa ttaacggttt gaaatcttct ataggtggct aattaggtgc taaagtagtg
    14761 aattaggtag taaatttaga tgtcaaaaga tgaaaaaata tttgttaggt ggtaaaattt
    14821 aggtactaat ttaggtacct aaggatgaat gttatgaaaa ctattaaaat ggttgctgat
    14881 gaattgaatg taactaaaca aactattgtt aataatgcta aaagcttaaa tatatctttt
    14941 gaaaaagaaa atggaattaa ttatattaat gataatgatt gtttaaaaat tatagaaaag
    15001 atcactaaga aagaaaggac aatgcaaaaa aaagaatcaa taaaaaaaga aagatttaat
    15061 gaaaatactg cagagtttga aaaacatata tacaataatt caaatagttt tgagtcatta
    15121 aaaacaaaag taaatgaatt agaaaagcaa atagaaatct ttgaaactag agctaaaaat
    15181 gatgaaaaat atattgagaa tttaactaaa caactagatc aacaaaatag caatgttaat
    15241 acattaaata aactgttgga gaatcaacaa atattagctt tagaaagtaa taaaaagatt
    15301 caaaaactag aaaaccaatt agaagaagaa agacagctta attactcttt tgatacagcg
    15361 actaatgata gagaaaacat taatccgcaa gaagcaactt ttactgaaga atatcaaaat
    15421 atcaaccaac aacaaaagaa aatccaacca atagaaccag aattaaatca taagggtata
    15481 actgaagcga aaaatgatga cagtgcaaac gaagacgtat taaagagaga ggataaacta
    15541 tctgaagaaa tagagagtgg acctgaggac agggaagtag aaacacctaa aaaggggttt
    15601 tggagtcgtt tgtttggtag ttaaaataat taattaggca ctaaaagtta taaactttgg
    15661 gtattcggat tttatggtgg aaaagggcct ataagttact cttttccaat ttcttaataa
    15721 gtgtggaaaa atctacacca tagttgcctg ttttgtctcg gtctgttatt tgatacgaat
    15781 tgaaactatc gtataacata gctttgctga atgcacttga attaaatcgt ggcttcctct
    15841 ttttatggag cttttcatta aaaattattt tagctcgtaa ggcttcaaat gagtaccctc
    15901 tacccattcg ttctacttgc ctaatgatgc tatttataga ctctgtataa gcgttagtga
    15961 gccttttatc aaagtaattg aagatttcat cctgccagtt gtctacggct cttaataggt
    16021 ctttataggc gtttttagag ttgctggata aacagcattg tctccaatac ctgtaacgat
    16081 ctttggcttg ctcaaggtca tctgtatccc atatcaagta gaactcttct ttaagttcgt
    16141 aggcttcttt tagttcaggt aaattactta gccaagtatc caaaaggaat gaatctcgtt
    16201 cattcaagtc atgctttcgt ttaagaagga tatacctctc acgcataagg gtacgacttt
    16261 ctttggctgt catattggct ttaagagact tcctaacact atccaaggct tgattagcca
    16321 ttcggactac atgaaactta tctacaacta ctttagcgtg aggtataact gtattaactg
    16381 cgtctttgta ggacttccac atatccattg tgacatattc gatatatgta ttgtctttaa
    16441 tttcagaaag gcgttgaatg accgtatctt tgttacgatt gggttttatg tcatatatag
    16501 ttctacgttc tacattggtc aatacaagac gaggtttctt gataatgtgt atttcgtcaa
    16561 taccaagcca tttaggagtt tcaaactgat attcacgttc ttttaatgcc acatagtctt
    16621 taaagatgtt cctaacagtt ttctcgtcta caccaacact ttcagctacg tctacgaagg
    16681 tcttagacag agattgttct tcaatagacc ttataagcct tttagtcata ctacgctttt
    16741 cgtcaatgga tataaggcgt tcccaaaaag ttgtgccaca ttcacgacat ttataacgtc
    16801 tgcggtttaa ttgtaatcct actcgtttta aacgaatagg cagatccatg attagttgct
    16861 ttcttgatgt atgtttatat agcctgtcaa agccacattg agggcaacgt actggtggaa
    16921 aagttgcttc cactttaaac atcatgtcgg attcattttc ttgtggtggt tctattgttt
    16981 taagatctgg tagtaataat aagtctgaca tattgttcat cctttactac tctgtggtgt
    17041 tatagtatta aatatagatt tgatattgaa attatcattg ctaattattt tactaacatc
    17101 aatctcataa agcatttata tgattgaaaa caaaaagcct atcattcact atcctacaat
    17161 aaaaagggtt atcccatagt tacacgggat aaccttacaa ttattaaatt atgcagttgc
    17221 acagctacaa tctttgcact cgcaaacttc atcagtacag ttgtctacac attcttgact
    17281 acagtaaact tttcctgctt cttctacttt tgtttcccca agaagacaat tacagttcgg
    17341 tctcgcacat ttttccatac taaactcctc cttattattt aggtaaatct tcggttaaac
    17401 accaacctcg atctaataga ctaacgacgc aattatcaac aattcggtac cgaataaaat
    17461 tggcttcacg aatactgcga acgatgcctt tatcaaccaa tcgttgaagt tggttggaaa
    17521 tggcttgagg tttcatttca agctgttctg ccacctcgct aacagatgca tttggagttc
    17581 gaagcaaggt atgcagtatt ctaagccgtg tcccgttaga aagtatttta aaggtctcac
    17641 ttaaaccttc agcgtcctct gtatctaata aggggcgttc cgttagtttt ggttttggta
    17701 tacaccagtt ttcagacatt atttcctcct ccatttcaca attacattat atagtgtagt
    17761 agtttttgtg tcaagaacct gaagttcata tatgagcatc tttttatcag tacattataa
    17821 cgccttaata agataaaata taattccctc ttgtttgact acctacccgt aatcacccgt
    17881 gtttgattta taattttgtg gtattattat ttttccttag cattccacca aacaatccga
    17941 tttaaccact atttttttcg aattatcaaa atgctaattc cactatatat tccgaagacc
    18001 ctaaactttt agtgcctttt atataatgag aacttctggt aattcaacat tatgtaaact
    18061 aaagtatttc aaataattaa ctgtattaat actctcatca tgattgcgtt ataaacgttc
    18121 gtttttgata caaaacctct taacttaata ttaagaggtt tttcttggat atcgaactct
    18181 aaaaacttgt gttataatca atgtatcata aataccaaaa aatatgagtt ttcagacgat
    18241 gagagccgcg tttatttgca tcgagaacta gatttcatta gtaagtactc ataaaacgat
    18301 taaaagaggt ggtattcaaa
//
