LOCUS       NZ_CP029666            27063 bp    DNA     circular CON 08-MAY-2024
DEFINITION  Staphylococcus aureus strain AR_0225 plasmid unnamed1, complete
            sequence.
ACCESSION   NZ_CP029666
VERSION     NZ_CP029666.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN04901615
            Assembly: GCF_003193965.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 27063)
  AUTHORS   Benahmed,F.H., Lutgring,J.D., Yoo,B., Machado,M., Brown,A.,
            McAllister,G., Perry,A., Halpin,A.L., Vavikolanu,K., Ott,S.,
            Zhao,X., Tallon,L.J., Sadzewicz,L., Aluvathingal,J., Nadendla,S.,
            Voskania-kordi,A., Simonyan,V., Patel,J. and Shawar,R.M.
  TITLE     FDA/CDC Antimicrobial Resistant Isolate Bank Genome Sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 27063)
  AUTHORS   Benahmed,F.H., Lutgring,J.D., Yoo,B., Machado,M., Brown,A.,
            McAllister,G., Perry,A., Halpin,A.L., Vavikolanu,K., Ott,S.,
            Zhao,X., Tallon,L.J., Sadzewicz,L., Aluvathingal,J., Nadendla,S.,
            Voskania-kordi,A., Simonyan,V., Patel,J. and Shawar,R.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) Center for Devices and Radiological Health,
            US Food and Drug Administration, 10903 New Hampshire Avenue, Silver
            Spring, MD 20993-0002, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: canu v. 1.4
            Genome Coverage                   :: 23.07x
            Sequencing Technology             :: Pacbio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003193965.1-RS_2024_05_08
            Annotation Date                   :: 05/08/2024 03:43:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,968
            CDSs (total)                      :: 2,886
            Genes (coding)                    :: 2,790
            CDSs (with protein)               :: 2,790
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 96
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 96
            Pseudo Genes (frameshifted)       :: 53 of 96
            Pseudo Genes (incomplete)         :: 46 of 96
            Pseudo Genes (internal stop)      :: 22 of 96
            Pseudo Genes (multiple problems)  :: 24 of 96
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029666.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..27063
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="AR_0225"
                     /db_xref="taxon:1280"
                     /plasmid="unnamed1"
     gene            complement(1110..1304)
                     /locus_tag="CSB81_RS00005"
                     /old_locus_tag="CSB81_2824"
     CDS             complement(1110..1304)
                     /locus_tag="CSB81_RS00005"
                     /old_locus_tag="CSB81_2824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001004925.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            1414..2106
                     /locus_tag="CSB81_RS00010"
                     /old_locus_tag="CSB81_2825"
     CDS             1414..2106
                     /locus_tag="CSB81_RS00010"
                     /old_locus_tag="CSB81_2825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative immunity/bacteriocin fusion bifunctional
                     protein"
                     /protein_id="WP_000691527.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="putative immunity/bacteriocin fusion bifunctional
                     protein"
     gene            complement(2274..2423)
                     /locus_tag="CSB81_RS15535"
                     /old_locus_tag="CSB81_2826"
     CDS             complement(2274..2423)
                     /locus_tag="CSB81_RS15535"
                     /old_locus_tag="CSB81_2826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000695366.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(2967..>3257)
                     /locus_tag="CSB81_RS00015"
                     /pseudo=""
     CDS             complement(2967..>3257)
                     /locus_tag="CSB81_RS00015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009384749.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(3277..4260)
                     /locus_tag="CSB81_RS00020"
                     /old_locus_tag="CSB81_2828"
     CDS             complement(3277..4260)
                     /locus_tag="CSB81_RS00020"
                     /old_locus_tag="CSB81_2828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_110230789.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKLKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFENRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            4686..5429
                     /locus_tag="CSB81_RS00025"
                     /old_locus_tag="CSB81_2829"
     CDS             4686..5429
                     /locus_tag="CSB81_RS00025"
                     /old_locus_tag="CSB81_2829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_000843732.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(5656..5841)
                     /locus_tag="CSB81_RS00030"
                     /old_locus_tag="CSB81_2830"
     CDS             complement(5656..5841)
                     /locus_tag="CSB81_RS00030"
                     /old_locus_tag="CSB81_2830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276570.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000797248.1"
                     /translation="MKNRIREYRKQKGISQETLSKELKVSRQTINAIENNKYDPTLTLA
                     FKLARLFDTTVDELFS"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(5846..6184)
                     /locus_tag="CSB81_RS00035"
                     /old_locus_tag="CSB81_2831"
     CDS             complement(5846..6184)
                     /locus_tag="CSB81_RS00035"
                     /old_locus_tag="CSB81_2831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001049146.1"
                     /translation="MNLIPFIIILIFSCLWTAITNKYLPSETLDKKGQQDRYDERQRKM
                     FIEILAKSFIWIVYCMLFTLVLKFTGLSPSIEGSWFSQYPEIFFIIVALFLMLFNYYTT
                     NKKYTSKG"
                     /name="hypothetical protein"
     gene            complement(6430..7038)
                     /locus_tag="CSB81_RS00040"
                     /old_locus_tag="CSB81_2832"
     CDS             complement(6430..7038)
                     /locus_tag="CSB81_RS00040"
                     /old_locus_tag="CSB81_2832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000583528.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTFGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKDVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGKAISKIAKEVNITRQTVYRIKHDKGLS"
                     /name="recombinase family protein"
     gene            complement(7466..8311)
                     /gene="blaZ"
                     /locus_tag="CSB81_RS00050"
                     /old_locus_tag="CSB81_2833"
     ARG             complement(7470..8311)
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.64"
                     /coverage="100.0"
     gene            8418..10175
                     /gene="blaR1"
                     /locus_tag="CSB81_RS00055"
                     /old_locus_tag="CSB81_2834"
     ARG             8419..10172
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.38"
                     /coverage="100.0"
     gene            10165..10545
                     /gene="blaI"
                     /locus_tag="CSB81_RS00060"
                     /old_locus_tag="CSB81_2835"
     ARG             10166..10542
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.41"
                     /coverage="100.0"
     gene            10809..11387
                     /locus_tag="CSB81_RS00065"
                     /old_locus_tag="CSB81_2836"
     CDS             10809..11387
                     /locus_tag="CSB81_RS00065"
                     /old_locus_tag="CSB81_2836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690637.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(11610..11795)
                     /locus_tag="CSB81_RS00070"
     CDS             complement(11610..11795)
                     /locus_tag="CSB81_RS00070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001037130.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            12057..12729
                     /locus_tag="CSB81_RS00075"
                     /pseudo=""
     CDS             12057..12729
                     /locus_tag="CSB81_RS00075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(12898..13469)
                     /locus_tag="CSB81_RS00085"
                     /pseudo=""
     CDS             complement(12898..13469)
                     /locus_tag="CSB81_RS00085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001079940.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /name="HTH domain-containing protein"
     gene            complement(13745..14539)
                     /gene="aph(3')-IIIa"
                     /locus_tag="CSB81_RS00095"
                     /old_locus_tag="CSB81_2840"
     ARG             complement(13749..14539)
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(14632..15162)
                     /gene="sat4"
                     /locus_tag="CSB81_RS00100"
                     /old_locus_tag="CSB81_2841"
     ARG             complement(14636..15162)
                     /name="sat4"
                     /gene="sat4"
                     /gene_name="streptothricin N-acetyltransferase Sat4"
                     /tool="amrfinderplus"
                     /drug_class="STREPTOTHRICIN"
                     /identity="97.78"
                     /coverage="100.0"
     gene            complement(15159..>15794)
                     /locus_tag="CSB81_RS00105"
                     /pseudo=""
     CDS             complement(15159..>15794)
                     /locus_tag="CSB81_RS00105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009251744.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /name="aminoglycoside 6-adenylyltransferase"
     gene            complement(15935..16609)
                     /locus_tag="CSB81_RS00110"
                     /old_locus_tag="CSB81_2842"
     CDS             complement(15935..16609)
                     /locus_tag="CSB81_RS00110"
                     /old_locus_tag="CSB81_2842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105956.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(<16666..16842)
                     /locus_tag="CSB81_RS00115"
                     /old_locus_tag="CSB81_2843"
                     /pseudo=""
     CDS             complement(<16666..16842)
                     /locus_tag="CSB81_RS00115"
                     /old_locus_tag="CSB81_2843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000469890.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0050380 - undecaprenyl-diphosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016311 - dephosphorylation [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /name="undecaprenyl-diphosphate phosphatase"
     gene            complement(16856..17593)
                     /locus_tag="CSB81_RS00120"
                     /old_locus_tag="CSB81_2844"
     CDS             complement(16856..17593)
                     /locus_tag="CSB81_RS00120"
                     /old_locus_tag="CSB81_2844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000369394.1"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="WP_000369394.1"
                     /translation="MDNLLRTEFIKLKRSYMFLISILGTCVAPFMVVVASFISMRTKVP
                     TPNIVFKQLFEEVSLYHMLIIGPPLYGVIIAYLFGREYIEDTLKNLLIIPISRESFLVS
                     KIILLFLWIQTLSVIAWLLTLMLGMLLHFQGLSQSLIIDSFFTFVIGGVLLWILSPPII
                     ILSIYFKNYVPTIVLTIIITLINLMTANSEHRGLFPWAAVGDISRGTLPNTYPFLLSLI
                     IIIVTSIFSVIILFSYFKKTDIS"
                     /name="ABC transporter permease"
     gene            complement(17586..18515)
                     /locus_tag="CSB81_RS00125"
                     /old_locus_tag="CSB81_2845"
     CDS             complement(17586..18515)
                     /locus_tag="CSB81_RS00125"
                     /old_locus_tag="CSB81_2845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074567.1"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA];
                     GO:0042626 - ATPase-coupled transmembrane transporter
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000793446.1"
                     /translation="MKNLNNIIEINNLTKQYGSQIAVNNLSITVESGQIYGFLGRNGAG
                     KTTTIRMLLGLIKPTKGNIKIFEKEFESNKTEILKNIGAMVETPGFYSNLTAKENLTIN
                     AKILGIQKENAIEEVLEIVGLASEKVKLFKNYSLGMKQRLGIARALLHNPELLILDEPT
                     NGLDPIGIKEIRKLIKDLAQSRNITILISSHILSEIEQLVDKVGIIHNGVLLEEIMYED
                     LKKKNRQFISISVSDEEKVACLLETNFGIYDYKIKENGEFKIYSHIDRQQEINRLLVLN
                     NIDVFQMRVIEDNLETYFEDLVGGGTIG"
                     /name="ABC transporter ATP-binding protein"
     gene            complement(18631..19512)
                     /locus_tag="CSB81_RS00130"
                     /old_locus_tag="CSB81_2846"
                     /pseudo=""
     CDS             complement(18631..19512)
                     /locus_tag="CSB81_RS00130"
                     /old_locus_tag="CSB81_2846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015581923.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0000155 - phosphorelay sensor kinase activity [Evidence
                     IEA]; GO:0004673 - protein histidine kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /name="sensor histidine kinase"
     gene            complement(19509..>19886)
                     /locus_tag="CSB81_RS00135"
                     /old_locus_tag="CSB81_2848"
                     /pseudo=""
     CDS             complement(19509..>19886)
                     /locus_tag="CSB81_RS00135"
                     /old_locus_tag="CSB81_2848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019834602.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]; GO:0006355 - regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /name="response regulator transcription factor"
     gene            complement(19944..20618)
                     /locus_tag="CSB81_RS00140"
                     /old_locus_tag="CSB81_2849"
     CDS             complement(19944..20618)
                     /locus_tag="CSB81_RS00140"
                     /old_locus_tag="CSB81_2849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WP_001105960.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            21092..22558
                     /gene="msr(A)"
                     /locus_tag="CSB81_RS00145"
                     /old_locus_tag="CSB81_2850"
     ARG             21093..22555
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            22657..23556
                     /locus_tag="CSB81_RS00150"
                     /old_locus_tag="CSB81_2851"
     CDS             22657..23556
                     /locus_tag="CSB81_RS00150"
                     /old_locus_tag="CSB81_2851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000196697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mph(C) family macrolide 2'-phosphotransferase"
                     /protein_id="WP_000196697.1"
                     /translation="MTRHNEIIKCAEKYQLHIQPQTISLNESGLDFQVAFGKDKHGVEW
                     VLRLPRRPDVYKRTKPEKQTVDFLQKNVSFEIPKWKVHAKDLIAYPKLTGKPAATIDPE
                     IQNYVWEIEHKPLPENFINTLAETLVDLHNIPEENINVQHINIKTIQEIKNDFQRRMNK
                     VKETYGVSDELWNRWKQWLENDELWPRHATMIHGDLHPGHIMVDNQANVTGLIDWTEAT
                     HSDPSMDFIGHHRVFDDEGLEQLITAYGKAGGEIWPRMKEHIIELNAVFPMFIAEFAME
                     SGESAYETMALKELGMKE"
                     /name="Mph(C) family macrolide 2'-phosphotransferase"
     gene            complement(24140..24559)
                     /locus_tag="CSB81_RS00155"
     CDS             complement(24140..24559)
                     /locus_tag="CSB81_RS00155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418034.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_000418035.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            24683..25654
                     /locus_tag="CSB81_RS00160"
                     /old_locus_tag="CSB81_2854"
     CDS             24683..25654
                     /locus_tag="CSB81_RS00160"
                     /old_locus_tag="CSB81_2854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="WP_000481279.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(25826..25918)
                     /locus_tag="CSB81_RS00165"
     CDS             complement(25826..25918)
                     /locus_tag="CSB81_RS00165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001791613.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(26075..26422)
                     /locus_tag="CSB81_RS00170"
                     /old_locus_tag="CSB81_2855"
     CDS             complement(26075..26422)
                     /locus_tag="CSB81_RS00170"
                     /old_locus_tag="CSB81_2855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000119690.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(26441..27058)
                     /gene="cadD"
                     /locus_tag="CSB81_RS00175"
                     /old_locus_tag="CSB81_2856"
     ARG             complement(26445..27058)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             22658..23553
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             21093..22558
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             22658..23556
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             complement(14633..15150)
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="97.16"
                     /coverage="95.56"
     ARG             complement(7467..8311)
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.44"
                     /coverage="100.0"
     ARG             complement(15457..15758)
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.0"
                     /coverage="36.23"
     Typing          complement(2765..2912)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          complement(2970..3146)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="93.258"
                     /coverage="94.0"
                     /evalue="6.2e-68"
     Typing          complement(3278..4260)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.492"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          4687..5429
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 acctcattca aaaatatttt tgaatgtatt ataacttata tttttaaata atcataggtg
       61 ctttattcca attgctttat tgacgttgag cctcggaacc cttaacaatc ccaaaacttg
      121 tcgaatggtc ggcttaatag ctcacgctat gccgacattc gtctgcaagt ttagttaagg
      181 gttcttctca acatcaataa atttttcggc ataaatgcgt gtctatgcgt agacatggag
      241 acacttcaga attatggagt gattacatga gtttaactat ttttctttat tcagttttag
      301 gaagtttatt agcaaattat atctacgaaa aatcttcaaa ataaataact ttttcggttc
      361 tactttgtac actttatcta cctggtagac ctaattgtta ttgctttaca ggtctaaaat
      421 tcgtcgttat aatctagtta aatcccgtaa gggcgcactt atacgtcgga taaatcgaca
      481 tgtgcaaaaa cgtaatcgac cttcgtcgat ttttttattt caaaattaaa gaaacggctt
      541 gagatattcc gagcagttat aaaaattaat ttgcgttgaa tattgctact acattcttga
      601 aaaagtgatg tagatttata gcccataact tttttgaatt acatcgacga tacggcgtcg
      661 aaagaaaaat aaatagaccg tatgaaagaa aaagctacct cactttatct ggggtagctt
      721 ttatttttta tgcccttatt ttgaatttta agagggcatt ttaaagattt aggggtgatt
      781 catatagttt tatatctaaa acttatatat gcttttaaaa cgcaaatatg agccaaataa
      841 atatatgcta ttttcaaaaa caaaaatttg agcaaaaaca ataactattt ttagacactg
      901 cccatttaca tgcaaattaa aaattagcat aaaattcttt aaaacttccc cacgtttttc
      961 taaattcctg tagggcgttt ttatcaaaaa tcaagacaag aagaaactcg ttcacactcg
     1021 tttcaaaaaa acaagaaatc taatctatac acctaccgtt ttccaacccc ctcaaagcat
     1081 acaaattaaa aacaaaatta ttcataatct tactttcttt taacaaaaac ataaaaacca
     1141 taaatagaca aattaactat caaaggcaat aaacagtata aaaaaaccac gaataaatct
     1201 tcatcaacat ctaaaataaa aaagaataaa acaattaaca aaatactaat taacaaacct
     1261 aaaagtggca aactttttat atatttttct aaattttcat tcataaaata gactcctttc
     1321 aaaaatatgt ttataaatat attaaaataa atattgattt tataaagcgc ttacttatac
     1381 aattaaaata tcttattatc ttggaggtat caaatgaaaa ttataaaatt attttcaata
     1441 atttccttgt tcctactggt atttagcgcg aatttttcta atgcttacgc aaatgaagaa
     1501 caaaaaagtt ctttactaga aaatcaaaaa gaaaaattga aaagcaaaaa catcgaagta
     1561 tcacaaatga ccaagaaaga aataagtttt ctagaacaat tgcaaaataa aaatgaagat
     1621 atgcaaaaat tcgaaaagca aatgaaaaaa gaaggattta aaaaaataaa gctagaagac
     1681 aaaaattcta aattaaaata tctagctaca gaagcaaatg ataaaaatgc atatggctac
     1741 atagctaata acgcttataa aaatgaaaaa acaaaagaaa ttgtagtttc tgaaacaata
     1801 tatgataact acaacaaaaa aatcacaaaa ttcattgccg aaaaaagaag tatgactgaa
     1861 aacaaagagg gaaaaatact tattaacaaa aattacgttg aatataaggc tgaaaaagtt
     1921 gataaaaaca gaccggtaac atatgcagga ttcaaatgga acggcaaagc attcgcttgt
     1981 agtatggctg gactttatgc atgtgctcac tactgtggag tatgggcaat cgtaaatcca
     2041 atagccggcg gtgtatgtga agcagtttgc ggaactgcat ttgcagctgg atgctctgta
     2101 ggttgatttt attccaattg ttttattgac gttgagcctc ggaaccctta acaatcccaa
     2161 aacttgtcga atggtcggct taatagctca cgctatgccg acattcgtct gcaagtttag
     2221 ttaagggttc ttctcaacat caataaattt tttcggcata aatacgatgt tccttattta
     2281 tcctcataaa aaacaatagc tgaaatatat aaccaattac tgtgtgtttg aatttctaat
     2341 acatgaatat cattctttaa aaacctatta acttgtttat ctaattgacg atgagtaaaa
     2401 gtagcgaaag ttttaatctt catgatatct ctccttttat aaaaatagca atccttatta
     2461 caatattaaa cacttttatt ttggatttta agaggcattt tgaagactta gaggcaaatc
     2521 atataggttt tgtacttaaa aatctataca gtctcttaaa acgcaaatat gagccaaata
     2581 aatatatgct aatttcacaa acaaaaattt cagcaaaatc agtgactaat ttttagatac
     2641 tgcccattta catgcaaatt aaaaattagc ataaaatact ttaaaacttc cccatgtttt
     2701 tctaaattcc tgcagggctt ttcttatcaa aaacttagaa attttaattt aactctaaaa
     2761 tctccgtaag agcataaggg aaatttgcta tcattcaaaa atgatagatc tggcaaggcc
     2821 agacattcca agggttttaa gttattttaa agtgatatca tacaaagctg tagtgtcaca
     2881 cttttgtgac actacataca gcatttgtca caaaaataag acagcacttt tttacagaaa
     2941 aacaataaaa aagacatcag ttatcactaa tgtcttaaat aataattttg cttttcgaaa
     3001 ttccaaattg cggtaattga atgtgctttt tcttcttcgt ctgtcgtttt atcttcatca
     3061 cttgtattaa tcaaattacc atcttcggca tcgtctaagt ttaaaatttt atgcttttgt
     3121 ttaagcaatc caccataact taacatacgt tttcgataca aacctttttc taaatcactt
     3181 acaatttctt gatttttttc gtcgtcatca gttaaaaagt cagatgattt aacggaatat
     3241 tttgatgtct cttcgagtgt tataaaatca tttgaattat tgattaaaga tattatattg
     3301 tttcatgttt ttacggcgca tataaagggc atgtgtttct tcaagttcag ttagaattgt
     3361 ttgcattaaa taagcttgca ttgacttgat tgtttccttt tggcctttaa ctcccctatc
     3421 atgtatagct tttttaagtc tttttaaaga agttaatatt tcatcctcaa tgtcctctaa
     3481 catgtaatgc atatcttcat gccttgaatt aaatgatttt tttgctttaa gaataacagc
     3541 ctttatgatt tctaaatctc tataatcata ttttaataaa taattagtta gttgttctgg
     3601 gaattcttgc aatagcattt ctttatcatc aaaattatgt gtaaattgat ttgaatgatt
     3661 tgaatgatta ctaatttcat ttttgtactt tatatcattc aagtcattca tatcattatt
     3721 ctcagtatca ttaaagtcaa tgtcattaaa gtcagtatca ttagtgttcg attttcgaac
     3781 ttctggacgt tcgattttcg aacttctgga cgttcgattt tcgaacttct ggacgttcga
     3841 ttttcgaact tccttctcgc cgtaaggttc aacatcgttt tcttcttttt ctattttgta
     3901 aatatcacgt tctgtgacaa taggtttcat taaatataga atatttggtt tatttaaacc
     3961 acgtcgtttt tgaatgagta gaccatcgtt ttctaaccct ttttttaatt ttgttaactt
     4021 ttctttttta caatttaaga tttccattag cttttcattt gaataaacaa agtaaatgtt
     4081 accatcttca tcaacccagc tatttttaat agataaattt aagcgatcac gtaagatagc
     4141 ataggctatt ttcatatcat tagttagatt tttataattt tcactggtaa agaatacttt
     4201 agggatttga taaaatcttt ctttgtaatt ttcttgcact gtaaaatatt gattttgcat
     4261 gacaaaaaac ctctttccat attttagttt ggtaagaggt aataaaacgt ttttatttag
     4321 ctttacattt atttaatgat ttaggtgctt gcactaagat attattcatt atataataca
     4381 agtatcgaaa attatataaa taaacagttt ctaaacgttt tattaccaaa ccccgactat
     4441 taccagtagt tggggttttt gttatattaa gtttattata gcactttaaa taaacttata
     4501 aaagggaaaa tatagcttta tcaagggttt ataaaccctt gataaatatc ataaaccttt
     4561 cataaaccct tgataaaaag gttgatggat gtttattttt atttattaat cactttatta
     4621 ttaagcatta taagcttata atattttatc aagggtttat aaacatttta taaagggttg
     4681 atgatatgaa aagtgtgaaa aagttgagtg aagaattagg ggttagtaag caaacgattt
     4741 ttaataatat taagcgattg aatatagaga caataaaaca ggaaaacact tcgtttatta
     4801 aagaagatac cgatatagaa aaaatcattc aaagagtaaa tgaaaataaa aagaaatatg
     4861 gttttgaaag tactactgaa gacaaacaaa aaaaagggtc ggataatatt aattttgaat
     4921 cgaaaagcga tgctcaaata gtagaaatcc ttaaaaatca gattgatact ttaaataatc
     4981 aaattgaaaa acaagaaagt cgtcatgaaa caacaattga attttacaga aaagagttgc
     5041 aagaaagatc aaaattgctt gaaaatcagc aagttctggc attagagagt aataaaaaga
     5101 ttcaaaaatt agaaaatcaa ttagaaaaag aaaaacacct taattatccc tttgatacat
     5161 ctactaacac tagacaaaac gttgatgcac aagaaaaaac atatactact aatcctgtaa
     5221 atattaacag agatcaggaa gaaactaaag aaacagagat tcaatataag gatatatctg
     5281 gaagtcaaag cgacgaaagt acacaaggtg aagaagcaaa aaaagaagac gttccagcta
     5341 atctaaatga caatgatagt gatatagaag aaaagagtga agaaacggaa cctaaaaagg
     5401 ggttttggag tcgtttgttt ggtagctaaa ataattgatt aggcactaaa agttataaaa
     5461 ttttagtgtc ttttatatag tgagaacttc tggtaatcat cgattatgta aactaaagta
     5521 tttcaaataa ttaactgtat taatactctc atcatgattg cgttataaac gttcgttatt
     5581 gagacaaaat ttaatagtac tactacacaa aaagagagtg cgaattcgca ctctcttttt
     5641 gtgataaatg aatggttaag aaaataattc atccacagtt gtatcaaaca atcttgccaa
     5701 cttaaatgct aatgtcaatg taggatcata tttattgttt tctattgcat taatagtttg
     5761 cctagacact tttaattctt tacttaaagt ttcttgagaa attccttttt gttttctata
     5821 ttctctaatt ctatttttca ttaatttaac ctttagatgt atatttttta tttgtagtat
     5881 agtaattaaa cagcataaga aatagtgcta caattataaa gaaaatttct ggatattgag
     5941 aaaaccaaga tccttcaata cttggtgaca aacctgtaaa tttaagcact agtgtaaata
     6001 acatacaata tacaatccaa ataaaacttt tagccagtat ttcaataaac attttacgtt
     6061 gtctttcatc gtatcgatct tgttgtcctt ttttatctaa tgtttctgaa ggtaaatatt
     6121 tgttagttat agccgtccat aaacaagaaa aaattaaaat aataataaaa ggaattaaat
     6181 tcattataac acctcataaa tgtaaaaagt atttgacatt tatgagtgta aatatttttg
     6241 atacaaatgt caaatacttt ttacattata atatatttta aaacacctta ttagtaaaac
     6301 aattactata tagaaagctg cgaactcgta ctcttttttc ttgtataatt attaaaatct
     6361 caattcaata atatgttatg gaatttgaga cactgtgaga gacgctcatt tgcattgaca
     6421 atcaatttat caagataatc ccttatcatg tttaattcta taaactgttt gtcttgtgat
     6481 attaacttct ttcgcaatct tactaatcgc tttgccttct tctaacattt ccaccacgcg
     6541 atgataaata acacgtttct gtgggtcttt agcatttggt gaataaagta aagggcgccc
     6601 tttatatacg cctttttcct tcgcaacttg aatcccttgc gcttgtcgac gtttactttc
     6661 atttctctct tgttctgaaa ccattgctaa tatttgaatg attaaatctt tcataaactt
     6721 atccagtaat ggattgccaa ttacttcatt catcataggt aagctggtaa tcattaactg
     6781 aacgtctttt tcttttaaat aattcacagt ttcaataatt tcatcatagt tacgtcctaa
     6841 acgatcaata gattccacaa cgaatcgatc tcccattctg acaaaattga gtgcttcttg
     6901 aaatacaggt ctattttcca ctgactttcc cgactgtttc tctgtaaaga ttttctccac
     6961 accaaacgtc tttaaattat ccaattgtct ttctaaattt tgatctatcg atgatactct
     7021 cgcataacct ataatcattc atcttcactc cataataaat atacacccta atcatacgtt
     7081 ttaattgtta taatttcaac aattcttttt gtatggttag ggtttaccct aatcgaacaa
     7141 taaaaaatac ttgtaaaatg ctattgtcac tttgcttgat atatgagaat tatttaacct
     7201 tataaatgag aaaaaagcaa cgcactttaa ataagatacg ttgctttttc gattgatgaa
     7261 cacctataat taaactattc atctattatt tatgattttt tgtatataca atatttctag
     7321 tttgttaaag agaattaaga aaataaatct cgaaaataat aaagggaaaa tcagtttttg
     7381 atatcaaaat tatacatgtc aacgataata caaaatataa tacaaactat aagatgttat
     7441 cagtatttat tatgcattta gaatattaaa attccttcat tacactcttg gcggtttcac
     7501 ttatcaactt atcatttggc ttatcacttt tattgtcttt attcgtaaaa atgactaaaa
     7561 caataggttc agattggccc ttaggataaa caaaagcaac atcatttcta gaagcatatg
     7621 ttattgcttg accactttta tcagcaacct tatagtcttt tggaacacca tctttaatta
     7681 aagtgtctcc gtttttatta ttaaacatta aatcaagtaa gaaattttta atttttttgc
     7741 ttaattttcc atttgcgata agtttattta aagtcttgcc gaaagcagca ggcgttgaag
     7801 tatctttttt gctctttggt gaatagtaat ttaattctat ctcatatcta actggatttg
     7861 ttactttatc tcctagttct tttagacgtt gtttaacttt tttgattcca ccgatttctt
     7921 ttataatttt attgtttgct gtattatcac tatatgtcat tgaagcctca ataagttctt
     7981 ttaaagtgat atcttttcct acatattttt ctaaaatagg agaataagca actatatcat
     8041 ctttgttaat atgtactttt ttatttaact tattataagg tacttgttct aacaaaatag
     8101 cactatttat cgcttttgaa gtcgaagcat aggcaaatct cttatctgaa ttaaatttta
     8161 cttccttacc acttttagta tttaaagcat aaacaccaat atgagcatta tatttttttt
     8221 ctaaatcatt taactctttg gcatgtgaac tgtttgaatt acatgcactt aaaactaaag
     8281 caattacaat taaaaatatt aactttttca aaataaaccc tccgatatta cagttgtaat
     8341 ttttaaaaat caataatatt acaattgtaa tattgatgtc aattgtttat tataaatatt
     8401 tgaaagaagg tgtcaaaatg gctaaattac taataatgag cgtagtaagc ttttgtttta
     8461 tatttctatt gttagtattt tttaggtaca tattaaaacg ctattttaat tatagtttaa
     8521 attataaagt ttggtatcta actatgcttg ctggattaat tccttttatc ccaattaaat
     8581 tctcttttat aaaatttaat aatgtgaata atcaagcgcc cacagttgaa agtaagtcac
     8641 acgatttgaa ccataacata aataccacca aacctattca agagttcaca acagatatcc
     8701 ataagtttaa ttgggattca attgataata tctgcacagt tatttggata gttttagtta
     8761 ttattttaag ttttaaattt ttgaaagcct tattatatct taaatattta aagaaacagt
     8821 cactttatct aaacgaaaat gaaaaaaata aaatagatac gatacttttc aaccatcaat
     8881 ataaaaaaaa tattgtgatt cgaaaagcag aggctattca atctccaata actttttggt
     8941 atgggaaata tattattttg attcctagtt catattttaa aagtgtaatt gataaaagac
     9001 taaaatatat aatactgcat gaatatgctc atgctaaaaa tagagatact ttacatttaa
     9061 ttatctttaa tatcttctct attattatga gttacaatcc attagtacat attgtaaaaa
     9121 gaaagataat tcatgacaat gaagtagaag ccgatagatt tgtccttaat aatattaaca
     9181 aaaatgaatt taaaacttat gcggaatcta ttatggactc cgtattaaaa accccatttt
     9241 ccaacaaaaa tatattaagc cattcattta atggtaaaaa atcattactc aaaagtagat
     9301 taattaatat aaaagaagcc gatctgaaaa agcagtcaaa attaattcta atttttattt
     9361 gtatttttac tttttttatc atgataattc aaagccagtt tttaatgggg caatccttaa
     9421 ctgattataa ttataaaaag cccttacaaa gcgattacca aattttagat gaaagtaaaa
     9481 attttggttc aaatagtgga tctttcgtta tgtacagcat gaagaaagac aaatactata
     9541 tttataatga aaaagaaagt agaaaaagat attctcctga ttcaacttac aaaatttatt
     9601 tagcactgtt tggacttgac cgtcatatta taagtgataa aaattcacgt atgtcatgga
     9661 atcataaaca ttatcttttc gagtcttgga ataaggaaca agatttaaat acagcaatgc
     9721 aaaattcagt taattggtac ttcgaacgta ttagtaatca aataccaaag aactatactg
     9781 cggctcaact caagcaatta aattatggta atgaaaattt gggaagttat aaaagctatt
     9841 ggatggaaga tagtttgaaa atatctaatc ttgaacaagt aatagttttt aaaaatatga
     9901 tggaacaaaa taaccatttt agtaaaaaag caaagaatca attatcttct tcattattga
     9961 ttaagaaaaa tgaaaagtat gaactgtatg ggaaaacagg tacaggtata gtaaacggga
    10021 agtataataa tgggtggttt gtaggttacg taattacaaa tcatgataag tattattttg
    10081 ctacacattt atcagatgga aacccgtctg ggaaaaatgc tgaattaata agtgaaaaaa
    10141 tattaaaagg aatgggtgtt ttaaatgacc aataagcaag ttgaaatatc tatggctgaa
    10201 tgggatgtta tgaatataat atgggataaa aaatcagtat cagctaatga aattgtagtt
    10261 gaaattcaaa aatataaaga agttagtgat aaaacgatta gaacattaat cacaagacta
    10321 tataaaaaag agattataaa acgatacaaa tcagaaaata tttattttta ctcatcaaat
    10381 attaaagaag acgatattaa aatgaaaact gctaaaacct ttcttaataa actgtatgga
    10441 ggggatatga aaagtttagt gctgaatttt gcgaaaaatg aagaattaaa taacaaagaa
    10501 attgaagaat tgcgagacat tttaaatgat attagtaaaa agtaattaga ggtatgtttc
    10561 aaacataata catatgtaaa ccatacttga ctcttattaa attagttttg ttaatgacat
    10621 ttaaaatata ttattaaaga tgagagtgtc cagaaaataa ccattttctg tacactcttg
    10681 ttttttgtct aaataagtaa gtattacata gaattatgtg ttcaaaaacc caacaaaaaa
    10741 tctatgttca caaaagacct cgtaatcaag ttatggtaca ctaaaggtgt atataggagg
    10801 tctgtatttt gaaaataggt tatgcaagag tttcaactgg attacaaaat ttgaatttac
    10861 aggaggatcg attaaataca tatggttgtg aaaagatatt taatgaccat atgagtggtt
    10921 caaaaagtaa gcgacctggt ttagataaag caattgaatt tgcgaggtca ggagatacga
    10981 ttgttgtttg gagattagat agactaggac ggaacatgga ggatttaatc acgttagtta
    11041 atgaacttaa cgaacgaggt gtgagttttc atagtttaga agaaaatata acgatggata
    11101 aatcaagttc tacaggacaa ttattatttc atttattcgc agcatttgca gagtttgaac
    11161 gtaatttaat tttagagcga tcatcagccg gtcgaattgc agcacgtgct agaggccgat
    11221 atggaggtag acctgaaaaa ttaaataaac aagatttaaa cttacttaag acactttatg
    11281 ataatggtac gccaattaaa acaattgcag agcagtggca agtttcacgt acaactattt
    11341 atcgttatct caataaatta gaggcaaaag agaataaaaa caagtagagc aactaatcta
    11401 gcttactata atgaatctac taaataattt tatatatcat taacatacaa agactttgat
    11461 tcaatgtcac tcgatgtaaa agagacgttc tgacagcgtc taaaatctca taatattttc
    11521 ctgttatgag attttaataa taacacaaga aaaaagcgta caaattcgta cgctttttta
    11581 atataatacc tgtttcacta atgaacgttt taagtatctt catcattaac tgaaactaca
    11641 gtaataatac tcgtcaacaa tattagtata gttaaaatag aaagacttag gactggcata
    11701 accgaactaa aattatattt gaaatataaa agtgctaatg aagagagaaa tgtaaaaata
    11761 ataaatacca aagaccattt ttctaattta ttcattggct tcacctcttt gaacttttat
    11821 ataatcatag gagatatttt tactacgatt tataaaaaat aagaagataa tcattattaa
    11881 agaaacgatt aatataatgt tgaatcctat agtatcacct aattcgttta cacctttgcc
    11941 taatatcgga gatacaaagc tttgtattaa taatgaaaga gatgcccata tagtaaatga
    12001 ggttctgttg caaagttgaa tttatagtat aattttaaca aaaaggagtc ttctgtatga
    12061 actatttcag atataaacaa tttaacaagg atgttatcac tgtagctgtt ggctactatc
    12121 taagatatgc attgagttat cgtgatatat ctgaaatatt aagggaacgt ggtgtaaacg
    12181 ttcatcattc aacggtctac cgttgggttc aagaatatgc cccaatttta tatcaaattt
    12241 ggaagaaaaa gcataaaaaa gcttattaca aatggcgtat tgatgagacg tacatcaaat
    12301 aaaaggaaaa tggagctatt tatatcgtgc cattgatgca gaggacatac attagatatt
    12361 tggttgcgta agcaacgaga taatcattca gcatatgcgt ttatcaaacg tctcattaaa
    12421 caatttggta aacctcaaaa ggtaattaca gatcaggcac cttcaacgaa ggtagcaatg
    12481 gttaaagtaa ttaaagcttt taaacttaaa cctgactgcc attgtacatc gaaatatctg
    12541 aataacctca ttgagcaaga tcaccgtcat attaaagtaa gaaagacaag gtatcaaagt
    12601 atcaatacag caaagaatac tttaaaaggt attgagtgta tttacgctct atataaaaag
    12661 aaccgcaggt ctcttcagat ctacggattt tcgccatgcc acgaaattag catcatgcta
    12721 gcaagttaag cgaacactga catgataaat tagtggttag ctatattttt ttactttgca
    12781 acagaaccag catttgtttt aatatttgtt ccaaagagcc atcatggctt tgacagagct
    12841 cttcttctat gcaaatgctt ttaatccgat ccacacgaaa attcctatat tcatttctta
    12901 gcctgcaaaa ccgattaagt accagttctg ttcataaaac cccagtgata taggctctat
    12961 cattctgctt tccggttctt gccctcctga tgcaggatat tgaattgata ttaccctttt
    13021 attgcagatt gcagtctgaa ttgctgcaat aacgttatcc gccaatgtat ttttctgtcc
    13081 agatgtgctg tacacgttaa tactgttctc caactcctgt gcatagtttt tttcaccatg
    13141 cttcaaaata gatttgattt tatacatagc tgaatcaaaa tcctttataa atgattcatc
    13201 tccatggcaa tttaaaaatt tccctgctgt aatcaatgca cccacttccg ccgctgtaaa
    13261 cattaccggc agaagtagga agccctctac aagaaaatat ccttttccgg cctcagatcc
    13321 aattggtatt ccggcttctt caagtgtccg gatatctctg taaactgtcc ttaagcttat
    13381 attaaatcgc tgtgcaattt ctttggcagg aattattttt ttgattgcag ctgaataaga
    13441 atagaggtta ctctgttaat cctgttcaaa ttttattcct cctctgtgac ttccataaaa
    13501 agtatatcct atgcgttctt aagctagctg ctgttagtgc ttctcattgc accctggtta
    13561 taaaagccat actcacaaac ctcttcacca aaactcttta catctctaat atagaactct
    13621 atctagcgaa cttttagaaa agatataaaa catcagagta tggacagttg cggatgtact
    13681 tcagaaaaga ttagatgtct aaaaagcttg tagttaaagc tttttagaca tctaaatcta
    13741 ggtactaaaa caattcatcc agtaaaatat aatattttat tttctcccaa tcaggcttga
    13801 tccccagtaa gtcaaaaaat agctcgacat actgttcttc cccgatatcc tccctgatcg
    13861 accggacgca gaaggcaatg tcataccact tgtccgccct gccgcttctc ccaagatcaa
    13921 taaagccact tactttgcca tctttcacaa agatgttgct gtctcccagg tcgccgtggg
    13981 aaaagacaag ttcctcttcg ggcttttccg tctttaaaaa atcatacagc tcgcgcggat
    14041 ctttaaatgg agtgtcttct tcccagtttt cgcaatccac atcggccaga tcgttattca
    14101 gtaagtaatc caattcggct aagcggctgt ctaagctatt cgtataggga caatccgata
    14161 tgtcgatgga gtgaaagagc ctgatgcact ccgcatacag ctcgataatc ttttcagggc
    14221 tttgttcatc ttcatactct tccgagcaaa ggacgccatc ggcctcactc atgagcagat
    14281 tgctccagcc atcatgccgt tcaaagtgca ggacctttgg aacaggcagc tttccttcca
    14341 gccatagcat catgtccttt tcccgttcca catcataggt ggtcccttta taccggctgt
    14401 ccgtcatttt taaatatagg ttttcatttt ctcccaccag cttatatacc ttagcaggag
    14461 acattccttc cgtatctttt acgcagcggt atttttcgat cagttttttc aattccggtg
    14521 atattctcat tttagccatt tattatttcc ttcctctttt ctacagtatt taaagatacc
    14581 ccaagaagct aattataaca agacgaactc caattcactg ttccttgcat tctaaaacct
    14641 taaataccag aaaacagctt tttcaaagtt ggcgtataac atagtatcga cggagccgat
    14701 tttgaaacca caattatgat agaatttaca agctataagg ttattgtcct gggtttcaag
    14761 cattagtcca tgcaagtttt tatgctttgc ccattctata gatatattga taagcgcgct
    14821 gcctatgcct tgccccctga aatccttaca tacggcgata tcttctatat aagcgtaccg
    14881 gttccaattt tttcgcagtt taacttttcc gacgcattta tcgtcttggt agtaaagata
    14941 tattatctta tcagtattgt caatatattc aaggcaatct gcctcctcat cctcttcatc
    15001 ctcttcgtct tggtagcttt ttaaatatgg cgcttcatag agtaattctg taaaggtcca
    15061 attctcgttt tcatacctcg gtataatctt acctatcacc tcaaatggtt cgctgggttt
    15121 atcgatatct ttcaggtgcc ctgctttcat ttctgtaatc actgttcccg cctctcttct
    15181 atatcagcgg catatgtgct atccaggcag ccggttttac cagtgtattt tttatacatg
    15241 tccctggtat attttgttat attcctatca tactccggat aggcataatg aagcctttcc
    15301 gccacctcac cggataccgc cctgaacaat tgatggcata gaaataatgc ttcccatatg
    15361 ttttcatagg aatccatccg gtaggtggac aaaagtttct cccacaaatc ctcggatata
    15421 tacctttcaa taaacttata gttcttgcct acacttcatt taaagcctgt ttcgatgccg
    15481 accttccatg atatcattct cagcagctca tggcgaacaa tctgattaaa atgatcaata
    15541 gcaaataaaa tttccttacg gcacaatcct ttaataacat aaggtgttac attccaaaat
    15601 tcattgcagc aatcatcata ctcccttgcg cttggctttc ttacatgata atctatatca
    15661 gtcggaacta tgtccctttt aattctacaa tctttatcaa ttagaacctt tattaattta
    15721 tcgcccttta ggtaattatc taactcttcc aagggcaata aggtaagatc aattttattg
    15781 taatcatcaa atagctataa tagatttaga ggtaaagaaa ttaaatacat tgaagagcag
    15841 aaagatttta caaaagagta ttttaataaa aatgatggtt ctgttgcaaa gtaaaaaata
    15901 tagctaatca ctaatatatc atgtcagtgt tcgtttaact tgctagcatg atgctaattt
    15961 cgtggcatgg cgaaaatccg tagatctgaa gagacctgcg gttcttttta tatagagcgt
    16021 aaatacactc aatacctttt aaagtattct ttgctgtatt gatactttga taccttgtct
    16081 ttcttacttt aatatgacgg tgatcttgct caatgaggtt attcagatat ttcgatgtac
    16141 aatggcagtc aggtttaagt ttaaaagctt taattacttt aaccattgct accttcgttg
    16201 aaggtgcctg atctgtaatt accttttgag gtttaccaaa ttgtttaatg agacgtttga
    16261 taaacgcata tgctgaatga ttatctcgtt gcttacgcaa ccaaatatct aatgtatgtc
    16321 cctctgtatc aatggcacga tataaatagc tccattttcc ttttattttg atatacgtct
    16381 catcaatacg ccatttgtaa taagcttttt tatgcttttt cttccaaatt tgatataaaa
    16441 ttggggcata ttcttgaacc caacggtaga tcgttgaatg atgaacgttt acaccacgtt
    16501 ctcttaatat ttcagatata tcacgatagc tcaatgcata tcttagatag tagccaacgg
    16561 ctacagtgat aacatccttg ttaaattgtt tatatctgaa atagttcata cagaagactc
    16621 ctttttgtta aaattatatt ataaattcaa ctttgcaaca gaacctccta actgtattac
    16681 caccttaaaa gtagttgcag acgcacttcc taaatcgtca gcagtgttta accacatatc
    16741 atcaacaata atcatatgac ctgttgatga tactggagca aattctgcca acccttcaac
    16801 tacacctaaa ataaatgctt taatctgctc tataaaaccc atttttctcc tccttttaac
    16861 ttatatcagt ttttttaaag tatgagaata atataattac actgaatata gatgtaacaa
    16921 ttatgataat taaagataat agaaatggat aagtattagg taatgttcct ctagatatgt
    16981 ctccaactgc agcccaagga aataatcctc tatgttcaga attagcagtc attaaattta
    17041 tcaaagtaat tattatggtt aaaacaattg tgggaacata atttttaaaa tatatcgaca
    17101 aaataattat tggtggagat aatatccata ataacactcc gccaataaca aatgtaaaga
    17161 atgaatcaat tattaaactc tggcttaacc cttgaaaatg caatagcata cctagcatta
    17221 aagttagcaa ccatgcaata acagatagtg tttgaatcca caagaataat aatattattt
    17281 tacttactaa aaaactttct ctagatatag gtataattaa taagtttttt aaagtatctt
    17341 ctatatattc tcttccaaac aaataggcta ttataacccc atatagagga ggtccaataa
    17401 ttagcatatg atataaactg acttcttcaa ataactgttt aaatacaata ttaggagtcg
    17461 gtactttcgt ccgcatacta ataaaagaag ctacaaccac cataaaaggt gctacgcatg
    17521 tacctaaaat acttattaga aacatatatg atctttttaa cttaataaat tctgtacgga
    17581 gtagattatc caattgtgcc acctcctact aagtcttcga aataagtttc tagattatct
    17641 tctatcactc tcatctggaa aacatcaata ttgtttaata ctaataatct attaatttct
    17701 tgttgtctat caatatgtga ataaatttta aattcgccat tttctttaat tttatagtca
    17761 taaattccga agttagtttc caacaaacat gcaacttttt cttcatctga tactgatata
    17821 cttataaatt gtctgttctt tttttttaaa tcttcataca taatttcttc taacaaaact
    17881 ccgttatgaa taatacccac cttgtctact aactgctcta tttctgacaa tatatgactt
    17941 gaaattaaaa tggttatatt tctagattga gccagatcct taatcaactt tctaatttct
    18001 tttatgccaa taggatctaa tccattcgtc ggctcatcaa gtatcaataa ttcgggattg
    18061 tgcaataaag ctctcgcaat ccctaaacgt tgcttcatac ctaaagaata atttttaaac
    18121 aattttactt tttcagaagc tagtcctact atttctaaca cttcttcaat tgcattttct
    18181 ttttgtatac ctaatatttt agcatttata gttaagttct ctttagctgt caaattacta
    18241 taaaaacctg gcgtttcaac catagcacca atatttttta aaatttcagt tttattactt
    18301 tcgaactctt tttcaaatat tttaatatta cctttcgtag gtttaattaa gcctaaaagc
    18361 attcttatag tagttgtttt gcctgcacca tttcttccta aaaaaccata aatttgtcca
    18421 ctttcaacag ttatactcaa attattaact gctatctgac ttccatattg ctttgttaag
    18481 ttatttattt caattatatt attcaaattt ttcacctctg gcacctttct tagtttgttg
    18541 ttacctttat cttacgcgcg attagaaaag gctgccttta tctattctta caaaaacagc
    18601 cgctaatctt acaaaaatga aagattggag ttatttaaat tgaatggtga atattgaacc
    18661 atcgtttaat gtagatgtag cacttacttt atggcctaag cgctttgaga ttgtgctgac
    18721 aatatataaa ccaataccgc ttgatttctc acttattcta ccgttatagc ccgagaaacc
    18781 tttatcaaag attttcggta aatcactcgc attaatgccg ataccgttat ctcggattga
    18841 taatttcttt gtattttcgt caaacgtaat ccacacatct ttgccacgtg catattttaa
    18901 tgcattgttt aatatttgct caatcataat tgatgcccat ttggcatctg ttaatataac
    18961 cgcttcactt ttctcataat gcaactttgt ttgatgatga ataaactgta tcgcataacg
    19021 tttaatcagt ggtcgaatta attcatctac actcacttcc ataaagacca tgtatgtctt
    19081 ttggttcatg agtttcaaat agttcagtgc aagattcgtg taattatcaa tttgtaagac
    19141 ttcattacgc acgttagaaa tcacgtgttc atcaggatct tcaagcagta actttgatgc
    19201 tgtaatcggt gtcttgattt gatgcaccca cattaaaaaa tatgactcta actcactttg
    19261 gtagttaata aagtcattac gaagtttatg gttttcgatt cttaaatctt cgttctgttc
    19321 ctgtagtgtt tattcttttt taaagttcat gtaatggata ccccagtaaa tcattgaaac
    19381 aaacaataca atacctagac caatcatata tgcttgcatc ggcacattat acatgaataa
    19441 tataaagtag aataaagcac aagtaaggat gacaatataa atttcacgtt ggattgattt
    19501 caagaaattc atacgtcacc tacacgatat ccgacatttt tcttcgtttc gataaaatct
    19561 gtaagtccta gtttttgtag ctttttgcgt aaacgtgtaa tgttgacagc aagcgtattg
    19621 tcatcaatga agtgttctga ttcccagcat ttttcgatta acgcattacg actgacgaat
    19681 ttgcccttgt tctggaataa gctatgcatg atttgcaatt cagtgtgtgt caggtctatg
    19741 gtttcttcat taaatttaag ctttgctgca tcaagtagta actcgcaatc atctactgtt
    19801 aaattattaa cttgagtggt gaaatcatac gtgcggcgta atagtgcttg aatcttagta
    19861 attgtaacag tcatattaaa tggctggttc tgttgcaaag taaaaaatat agctaatcac
    19921 taatatatca tgtcagtgtt cgtttaactt gctagcatga tgctaatttc gtggcatggg
    19981 gaaaatccgt agatctgaag agacctacgg ttctttttat atagagcgta aatacattca
    20041 atacctttta aagtattctt tgccgtattg atactttgat atcttgtctt tcttacttta
    20101 atatgacggt gatcttgctc aatgaggtta ttcagatatt tcgatgtaca atgacagtca
    20161 ggtttaagtt taaaagcttt aattatttta gccattgctg ccttcgttga aggtgcctga
    20221 tctgtaacta ccttttgagg cttaccaaat tgtttaatga gacgtttgat aaacgcatat
    20281 gctgaatgat tatctcgttg cttacgcaac caaatatcta atgtatgtcc ctctgtatca
    20341 atggcacgat ataaatagct ccattttcct tttattttga tatacgtctc atcaatacgc
    20401 catttgtaat aagctttttt atgctttttc ttccaaattt gatataaaat tggggcatat
    20461 tcttgaaccc aacggtagat cgttgaatga tgaacgttta caccacgttc tcttaatatt
    20521 tcagatatat cacgatagct caatgcatat cttagatagt agccaacggc tacagtgata
    20581 acatccttgt taaattgttt atatctgaaa tagttcatac agaagactcc tttttgttaa
    20641 aattatatta taaattcaac tttgcaacag aaccgtattt tatgagtaca ctctaaatta
    20701 aggagatgta taatcaatct aaaattgtat ttttatactt ttgttatata atctttctac
    20761 ttagagatat attgtaaaaa aaccaacaaa atgttatatt aacattacta ttttatcgat
    20821 gaaggaggat taaaatgaca gcttctatga gactcaaata aacctttttg aatacaaaac
    20881 taaattaatt caaaaaggct tgtccgcaat acacactcat aggatgactt atgtcatttt
    20941 ttatccttcg ataggaataa taaacgcttt caaatactaa aacatcataa taaattttta
    21001 agtgtttgaa agtgtaatgt gaatgagacg ggagtagcct gtctcatttt tttgcgtaca
    21061 cgtcctttaa atatacaagg agtgtataaa tatggaacaa tatacaatta aatttaacca
    21121 aatcaatcat aaattgacag atttacgatc acttaacatc ggtcatcttt acgcttacca
    21181 atttgaaaaa atagcactta ttgggggtaa tggtactggc aaaaccacat tactaaatat
    21241 gattgctcaa aaaacaaaac cagaatctgg aacagttgaa acggttggcg aaattcaata
    21301 ttttgaacag cttaacatgg atgtggaaaa tgattttaac acgttagacg gtagtttaat
    21361 gagtgaactc catataccta tgcatacaac cgacagtatg agtggtggtg aaaaagcaaa
    21421 atataaatta gctaatgtca tatcaaatta tagtccgata ttacttttag atgaacctac
    21481 aaatcacttg gataaaattg gtaaagatta tctgaaaaat attttaaaat attactatgg
    21541 tactttaatt atagtaagtc atgatagagc acttatagac caaattgctg acacaatttg
    21601 ggatatacaa gaagatggca caataagagt gtttaaaggt aattacacac agtatcaaaa
    21661 tcaatatgaa caagaacagt tagaacaaca acgtcaatat gaacagtata taagtgaaaa
    21721 acaaagattg tcccaagcca gtaaagctaa acgaaatcaa gcgcaacaaa tggcacaagc
    21781 atcatcaaaa caaaaaaaca aaagtatagc accagatcgt ttaagtgcat caaaacaaaa
    21841 aggcacggtt gagaaggctg ctcaaaaaca agctaagcat attgaaaaaa gaatggaaca
    21901 tttggaagaa gttgaaaaac cacaaagtta tcatgaattc aatttcccac aaaataaaat
    21961 ttatgatatc cataataatt atccaatcat tgcacaaaat ctaacattgg ttaaaggaag
    22021 tcaaaaactg ctaacacaag tacgattcca aataccatat ggcaaaaata tagcgctcgt
    22081 aggtgcaaat ggtgtaggta agacaacttt acttgaagct atttaccacc aaatagaggg
    22141 aattgattgt tctcctaaag tgcaaatggc atactatcgt caacttgctt atgaagacat
    22201 gcgtgacgtt tcattattgc aatatttaat ggatgaaacg gattcatcag aatcattcag
    22261 tagagctatt ttaaataact tgggtttaaa tgaagcactt gatcgttctt gtaatgtttt
    22321 gagtggtggg gaaagaacga aattatcgtt agcagtatta ttttcaacga aagcgaatat
    22381 gttaattttg gatgaaccaa ctaatttttt agatattaaa acattagaag cattagaaat
    22441 gtttatgaat aaatatcctg gaatcatttt gtttacatca catgatacaa ggtttgttaa
    22501 acatgtatca gataaaaaat gggaattaac aggacaatct cttcatgata taacttaaaa
    22561 actatacact aatttatatt gaatattagg ttcatttata tcaatataaa aaatacgttc
    22621 acaagaaaaa tataatagaa ataaggatcc aataaaatga ctcgacataa tgaaattatt
    22681 aaatgtgcag aaaaatatca attacacatc caacctcaaa caatctcatt gaatgaatcg
    22741 ggacttgatt ttcaagttgc atttggaaaa gataaacatg gagtagaatg ggttttgaga
    22801 ctaccaagaa gacctgacgt ttataaacga acaaaacccg aaaaacaaac ggtagacttc
    22861 ttacagaaga atgtttcatt tgaaataccg aagtggaaag tacatgcaaa agaccttatt
    22921 gcttacccaa aacttacagg taaacccgca gccacaatag atccagaaat acaaaattat
    22981 gtatgggaaa ttgaacacaa accattacca gaaaacttta ttaacacatt agctgaaaca
    23041 ctcgtagatt tacacaacat accagaagaa aacattaacg ttcagcatat aaatatcaaa
    23101 accatacaag aaataaaaaa tgactttcaa agaagaatga ataaagttaa agaaacttat
    23161 ggcgtatcag atgaattatg gaacagatgg aaacaatggt tagaaaacga cgaactatgg
    23221 cctcgacatg cgaccatgat acatggggac ttacatccag gacatataat ggtagataac
    23281 caagcaaacg tcacaggtct catagactgg actgaagcaa cccactccga cccatcaatg
    23341 gactttatag gacaccatcg tgtattcgac gacgaaggat tagagcaact tataacagca
    23401 tacggtaaag ctggaggtga aatatggcca cgaatgaaag agcatataat agaactcaat
    23461 gcagtattcc caatgtttat cgctgagttt gctatggaat caggagaatc ggcgtatgaa
    23521 acgatggcat tgaaagagtt aggtatgaaa gagtagaact tatattaaaa gaggcccatt
    23581 ttaaagacga aggcaatcct gatgaaattt taaaactgcg tttaattagt gatggtcttt
    23641 ggttttctat aatgtattaa atatctggac atggaacaaa tgcaacaaat ggaaagaatc
    23701 gttttcgaaa tttctaactc cttaaatcag gaggataaat aaacggtcat tttcattgaa
    23761 agcacttata taaatttcat caattttaat acctaccgta aatacatttc ataagtatta
    23821 aacagatgat taaaattttt agttaattta aatatttatg atagagatga ccttcaaatg
    23881 aacggttctg ttacaaagaa aaaatctata tttattttta gtaagtttta attatagata
    23941 tgtacacttt gagtaaacct aaataataca taaattatat tacaatatgt ttattataga
    24001 ggctaaagta tcttagaaat ttggatagta ggtttttcgg gaataaaagt atagttggct
    24061 ttaatatata attaagctaa gctatcattt atatttactc gattataatt cgcacttcaa
    24121 cttttttata acgtaaaaat taaaacgtag ttttatttat ctttagtaat atctttttaa
    24181 acactacagt ttcttcatta gttaaattag cgaagtaatg attattaagt tgataggctt
    24241 tcttttctaa tgttggccat aagtcttttg ctttatttgt actgtttatt agcacagttc
    24301 ttctattttc attatcagtt tgacgtgtta ttagatcctt tttggacatc ttatctaata
    24361 ttccagatat tgttgaaggt tctaaattta aagtattacc aatcgcttta ggtgtattca
    24421 aattactatt aatcaagcaa ttcaaaacac catattctgc tggagtaata ttatagggac
    24481 ttaataaact tttaaaatgt ttaaaaactc tattctgaga agtactcaac aaataattta
    24541 tacaattatc taattccaca actaaaacct ctcttaaatc attagtattg actcgcttat
    24601 catatcatga taagttttgt aggaaaatag ttttgcaaca aaaacatact tctacaaaac
    24661 aattgtgaaa gaaggctaat aaatgttcaa tgcggtagta gtgagaaaaa gtgcatcaaa
    24721 tgttagttat aaagtagaaa aagttgatga atctcattta tcgaagggtg atgtattagt
    24781 aaaagtggta tactcttcaa taaattataa ggatatgcta gctttacaat ataaaggcgg
    24841 tgtaattaga gattatccta tgattcctgg tatagatttt gcaggtattg ttgaatcaag
    24901 ttcgaatgat aagtttaaag aaggcgataa tgtattagtt actggttatg atgttggcgt
    24961 gacacataca ggtggatttt cagaatatgc acaagtgcct ggagagtgga ttgttcctat
    25021 tccccaagaa atgtctatta aagagtctat ggtatatggc acagccggtt ttacggcagc
    25081 attatcaatt tttgaactag aaaaatatgg aatgaatatc aaatcacaac ctgaaatttt
    25141 agtgtctggg gctacaggtg gtgtgggcag tgttgctata caaattttac ataaaattgg
    25201 atatgaaaat atcactgcta tcgtaagaaa agaaaagcaa atagaaatcg caaaaaaatt
    25261 aggtgcaaaa caagtaataa taattgaaga tgataataaa ccgcttaaaa aaggtatttt
    25321 tgattatttc ttagatacag tggggagtaa tgtaacatta tacggtttaa aacgtctaaa
    25381 ttatcaaggt gttgctactg tatgtggaaa tgtagcagga aattcactta acgctaatat
    25441 attaccgttt attcttagag gtattaaatt aattggcatt gattctgtat atgttgatca
    25501 taatatccgt gaagatatat ggagtaagtt agcaaatgaa tggaatatag gaaattcact
    25561 tctatacaat gaaattggat ttgaagaatt ctataaaacg atagatcagc ttttaaaagg
    25621 acaacattta ggaagaacta ttttaaaagt ataagtgtga gtattcatta atacatttac
    25681 tattaattca atcattttgc atttctctac taaccagtgt tataatttat ataacgaaaa
    25741 tgattaacaa ttaatgcacc aatccccaca ctattgcagt agtgtgggga ttttttcgat
    25801 gctggcttat aaagtcgcct attaattatt tgttgcgttt actaagccaa taagtataat
    25861 acgcaacagc acagccactg atgactggtg ctatgatgtg aacgaaaatg attagcaaag
    25921 taatgcacct cctctcttcg tcaattgacg cctgagagat aggcgactct attattatac
    25981 catctgtgaa tatacaagca tatctacttc cgataagtcg tcttatgtta tataactttg
    26041 ttttttatag tatcaagaca agaagaaact cgtttcaaaa accctcatga tttttagaga
    26101 aaaactctct tatttcatcg tctttaataa aataatatgc catctttcca tctttataaa
    26161 aatcaagtac ctcattttta tataaaagcc ttaaatgatg tgaagttgaa gcaacactca
    26221 ttttcaatat caaagaaata tcacaaacac acaactcatc ttctttaatc aaagataata
    26281 tgattttcaa tttcttctca tcacaaattt tttctaaaat gttaagtaat ttcttagatt
    26341 tatcatcttc taaaaaactt aaagcattgt taactttatc ctcatgtaca cagatcacat
    26401 cacaagtatt ttcataactc atataaaatc acaccctaaa ttaaaatata aatcctaaaa
    26461 ttgtttgaat agtgtcattt tcaataataa taaataaacc taaagctata taaataatag
    26521 ccataatcca acgactaaat ttctcaacaa tttctccaat tcctggaata ttagctaatt
    26581 tttgtgcagt aaacaccaag aagaaaatta aaattaaaaa gacaaacaga gtaagtaata
    26641 aattagtaac acttaatgtc acaaaatacg gaacaaataa accaatatta tcggcgccac
    26701 aacttgctat cgtaacaatt gcaaccgtac caactaattt agacaatcct ttttcattca
    26761 attctttttt agctctcttt tctccttcac aatcatcata aatagccact ttaattccaa
    26821 gataaattgg tattaaaccc aataaaccta atatccactt ttctggaaca taatttaata
    26881 caaaagctaa aaacaaacta actaatatta aaataataga ccctaaatat tgaccaacat
    26941 aaatatctct atattctttt ctagtctttg ctctagcaaa aaatattaat aaaattacta
    27001 ataaatcaac tgctgtagca atataaagaa cagcagcagc aacaaccgtt tgaatcataa
    27061 tac
//
