LOCUS       NZ_CP029083            20730 bp    DNA     circular CON 08-MAY-2024
DEFINITION  Staphylococcus aureus strain AR464 plasmid unnamed1, complete
            sequence.
ACCESSION   NZ_CP029083
VERSION     NZ_CP029083.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN07291557
            Assembly: GCF_003073755.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 20730)
  AUTHORS   Benahmed,F.H., Lutgring,J.D., Yoo,B., Machado,M., Brown,A.,
            McAllister,G., Perry,A., Halpin,A.L., Vavikolanu,K., Ott,S.,
            Zhao,X., Tallon,L.J., Sadzewicz,L., Aluvathingal,J., Nadendla,S.,
            Voskania-kordi,A., Simonyan,V., Patel,J. and Shawar,R.M.
  TITLE     FDA/CDC Antimicrobial Resistant Isolate Bank Genome Sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 20730)
  AUTHORS   Benahmed,F.H., Lutgring,J.D., Yoo,B., Machado,M., Brown,A.,
            McAllister,G., Perry,A., Halpin,A.L., Vavikolanu,K., Ott,S.,
            Zhao,X., Tallon,L.J., Sadzewicz,L., Aluvathingal,J., Nadendla,S.,
            Voskania-kordi,A., Simonyan,V., Patel,J. and Shawar,R.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2018) Center for Devices and Radiological Health,
            US Food and Drug Administration, 10903 New Hampshire Avenue, Silver
            Sring, MD 20993-0002, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: canu v. 1.4
            Genome Coverage                   :: 25.31x
            Sequencing Technology             :: Pacbio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003073755.1-RS_2024_05_06
            Annotation Date                   :: 05/06/2024 08:31:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,800
            CDSs (total)                      :: 2,718
            Genes (coding)                    :: 2,645
            CDSs (with protein)               :: 2,645
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 73
            CDSs (without protein)            :: 73
            Pseudo Genes (ambiguous residues) :: 0 of 73
            Pseudo Genes (frameshifted)       :: 42 of 73
            Pseudo Genes (incomplete)         :: 27 of 73
            Pseudo Genes (internal stop)      :: 13 of 73
            Pseudo Genes (multiple problems)  :: 8 of 73
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029083.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..20730
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="AR464"
                     /db_xref="taxon:1280"
                     /plasmid="unnamed1"
     gene            104..780
                     /locus_tag="CSC49_RS14535"
                     /pseudo=""
     CDS             104..780
                     /locus_tag="CSC49_RS14535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /name="replication initiator protein A"
     gene            <791..1073
                     /locus_tag="CSC49_RS14580"
                     /pseudo=""
     CDS             <791..1073
                     /locus_tag="CSC49_RS14580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199895.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            2284..2901
                     /gene="cadD"
                     /locus_tag="CSC49_RS00020"
                     /old_locus_tag="CSC49_2709"
     ARG             2285..2898
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="99.51"
                     /coverage="100.0"
     gene            2920..3267
                     /locus_tag="CSC49_RS00025"
                     /old_locus_tag="CSC49_2710"
     CDS             2920..3267
                     /locus_tag="CSC49_RS00025"
                     /old_locus_tag="CSC49_2710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000119691.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNQEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            3436..3528
                     /locus_tag="CSC49_RS00030"
     CDS             3436..3528
                     /locus_tag="CSC49_RS00030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001791613.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            3740..4714
                     /locus_tag="CSC49_RS00035"
                     /old_locus_tag="CSC49_2711"
     CDS             3740..4714
                     /locus_tag="CSC49_RS00035"
                     /old_locus_tag="CSC49_2711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4062 domain-containing protein"
                     /protein_id="WP_000072391.1"
                     /translation="MSNTKIKYQIFISSTYLDLIEERQAVVEAVLNSNNIPAGMELFNS
                     SSKSQWEIITQWINESDAVILLLGSSYGTIDSEENISYTEMEYNFAKSLGKPIYVFEMN
                     KASTESAEKSKKLDEFKTKVKENRLISPNINDISELKSKVSQTLMQSVPSEIKENSGWI
                     RVQDCGKNVKKLKKLDAIQRDLDTYDFLKEELYKIFMYVKTFYFQHTPFDDSYIEDIEN
                     YLLNYENNPHKSFMKIKVYDYKNFLKHLKNILILIKQGKKPLAQAGHFKLSFYEEDLKL
                     LQKNYKTTLVDIKGLNKHFYKECDRCLKAYNIFIEGINKHLYE"
                     /name="DUF4062 domain-containing protein"
     gene            complement(4834..5649)
                     /locus_tag="CSC49_RS00040"
                     /old_locus_tag="CSC49_2712"
     CDS             complement(4834..5649)
                     /locus_tag="CSC49_RS00040"
                     /old_locus_tag="CSC49_2712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019467708.1"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WP_000164958.1"
                     /translation="MTKNQNFIETKEYKRFAEFCDACIKYQYIGICYGQPGVGKTLSSR
                     YYTNWDTIEKQVNHRGWEDLASKTTDDILSVDKIFYNAPAEKQTKLRNDLYSITAIIDL
                     GQKLHVVNKYGHEHSKHYSDMFKYIDLIIVDEIDRLKVQHLEQLRAIYDEHNLAMIFIG
                     MPGIEKKLSRYPQLYSRIGFAHEFDNLSKDETHHILEYKWQDLGFDLKLEDFTDYEAIT
                     TIIKITKGNFRLIHRLFAQIDRIMDINGLDKISTEVVETARDSLVIGIR"
                     /name="AAA family ATPase"
     gene            complement(5642..7085)
                     /locus_tag="CSC49_RS00045"
                     /pseudo=""
     CDS             complement(5642..7085)
                     /locus_tag="CSC49_RS00045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790716.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Mu transposase C-terminal domain-containing
                     protein"
                     /name="Mu transposase C-terminal domain-containing protein"
     gene            complement(7057..7650)
                     /locus_tag="CSC49_RS00050"
                     /old_locus_tag="CSC49_2715"
     CDS             complement(7057..7650)
                     /locus_tag="CSC49_RS00050"
                     /old_locus_tag="CSC49_2715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690636.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690638.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNQKDLNLLKTLYDNGTPI
                     KTIAEQWHVSRTTIYRYLNKLEDKEDEKQGEVSN"
                     /name="recombinase family protein"
     gene            complement(7914..8294)
                     /gene="blaI"
                     /locus_tag="CSC49_RS00055"
                     /old_locus_tag="CSC49_2716"
     ARG             complement(7918..8294)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            complement(8284..10041)
                     /gene="blaR1"
                     /locus_tag="CSC49_RS00060"
                     /old_locus_tag="CSC49_2717"
     ARG             complement(8288..10041)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.56"
                     /coverage="100.0"
     gene            10148..10993
                     /gene="blaZ"
                     /locus_tag="CSC49_RS00065"
                     /old_locus_tag="CSC49_2718"
     ARG             10149..10990
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            11362..11970
                     /locus_tag="CSC49_RS00075"
                     /old_locus_tag="CSC49_2719"
     CDS             11362..11970
                     /locus_tag="CSC49_RS00075"
                     /old_locus_tag="CSC49_2719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002436987.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001566953.1"
                     /translation="MIVGYARVSSNDQNLERQLENLKTFCAEKIFTEKQSGKSIENRPV
                     LQEALNFLRMGDRFVVESIDCLGRNYDEVIHTVNYLKDKEVQLMITSLPMMNEVVGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRI
                     IYHRVVEMLEEGQSISKIAKEVNITRQTIYRIKNDNDLI"
                     /name="recombinase family protein"
     gene            12384..12677
                     /locus_tag="CSC49_RS00080"
                     /old_locus_tag="CSC49_2720"
     CDS             12384..12677
                     /locus_tag="CSC49_RS00080"
                     /old_locus_tag="CSC49_2720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_000726502.1"
                     /translation="MKKKFVSSCIASTILFGTLLGVTYKAEAATVHVAGGVWSHGIGKH
                     YVWSYYSHNKRNHGSTAVGKYSSFSGVARPGVQSKASAPKAWGGNKTFYSLH"
                     /name="lactococcin 972 family bacteriocin"
     gene            12752..14686
                     /locus_tag="CSC49_RS00085"
                     /old_locus_tag="CSC49_2721"
     CDS             12752..14686
                     /locus_tag="CSC49_RS00085"
                     /old_locus_tag="CSC49_2721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001670421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="WP_000713729.1"
                     /translation="MKKFKLFLDFSTLLLISGLLFLFFFKENEEIIPESSNILTISNWD
                     KSNSKSKVLDVIESGAKNQNIQIIKSVKDFDNKKEFFVFNSKRNNSDFIRNKTSLLTPS
                     DLLNREIKGKYYIIGEHFNVEELTSELKKAGLTSEVEYINRNILFFELVIDNDLLVPFI
                     FLGVLYLLYFLYDRGYNLKFYAIQKLHGFSTTRIIFHNIHIKIIYWLVLTAIFFIANIL
                     IIHIANLELDFLMFIRRFIVLLFVFACITTLLWLISYSLLLKLSIPLILKGKKGYKFSI
                     FMGTFTKCIMVLILSFLLAQNLNAYTKLKNIYDSEKIWQKLDNYYTLEISPNIRNSEEK
                     QILETNIYNLIKKSEQLGGLLLKNNNIANPDKNNYIPENGNVFFINNNFLNFYKNINHD
                     FKMIDNHSDKINVFIPPRLQYQKSEIQKNHQGWIDFQKQQNKKVDVQVLSKNVSVFSFD
                     RTTNLKFGYLDSPIVMLLTLDDLTGDFYLAAVSQGGYLFKDLDTLKQLLKDNHLEEEIS
                     GITNYKDSVLNELNETKTKMIITIVTIIINVFILLIATVFETIQYFSWNKKQLLLRKIH
                     GYSLFSSNVRYLTISILLSIMLAYTTHILFGSKILLFIIMSIAIIQHLLQIAYIKYLEK
                     YFKDLMREI"
                     /name="bacteriocin-associated integral membrane family
                     protein"
     gene            14690..15001
                     /locus_tag="CSC49_RS00090"
                     /old_locus_tag="CSC49_2722"
     CDS             14690..15001
                     /locus_tag="CSC49_RS00090"
                     /old_locus_tag="CSC49_2722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YxeA family protein"
                     /protein_id="WP_000831610.1"
                     /translation="MKRTLIIVTIVLLIIILSLLLVRNEHLDRFNPLLKEKVSYAKVPK
                     DTQDYRNITVYSKNGEKKSYKLDFLGYDPTKEYVKVNHKGKYVRSIEYITKDIPSFLK"
                     /name="YxeA family protein"
     gene            15013..15639
                     /locus_tag="CSC49_RS00095"
                     /old_locus_tag="CSC49_2723"
     CDS             15013..15639
                     /locus_tag="CSC49_RS00095"
                     /old_locus_tag="CSC49_2723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000593103.1"
                     /translation="MIKLENVFVKKGNKNILDGCNFNFEKGKSYALVGESGAGKSTLLN
                     IIAGFEDVSQGSIYIEDKLLKKKVDFYRYTLGYLFQNFALLENQTISQNLDLALKFKKN
                     KKDNMNLKKEVLKKVGLDLDIKRIVSSLSGGEQQRVALARLILKDPKIILADEPTGSLD
                     TKNGKIVIDLLLKLLDENKTMIVVTHDLELAKRFDVIVNISELRS"
                     /name="ABC transporter ATP-binding protein"
     gene            15877..16506
                     /gene="mobV"
                     /locus_tag="CSC49_RS14585"
                     /pseudo=""
     CDS             15877..16506
                     /gene="mobV"
                     /locus_tag="CSC49_RS14585"
                     /inference="COORDINATES: protein motif:HMM:NF013258.4"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MobV family relaxase"
                     /name="mobV"
     gene            16600..17145
                     /locus_tag="CSC49_RS00110"
                     /old_locus_tag="CSC49_2726"
     CDS             16600..17145
                     /locus_tag="CSC49_RS00110"
                     /old_locus_tag="CSC49_2726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001805533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000273005.1"
                     /translation="MYEIKTKNVGGWFHKEKQETGNIVITKTDFEKYTKQIKAAQMILD
                     DYECIKSGKSLKKAEKQNESLVNELTSVHMENEKLVEEFNDLAQRYNYLLSENEKKDKE
                     LNYTLKLFNQVFKIIKSMMKEERYHTLINHIDNHLDNSKIREVMTIDNNDEQFFKKKYQ
                     AQEREIIFKEDREDGYTL"
                     /name="hypothetical protein"
     gene            17529..18389
                     /locus_tag="CSC49_RS00120"
                     /old_locus_tag="CSC49_2727"
     CDS             17529..18389
                     /locus_tag="CSC49_RS00120"
                     /old_locus_tag="CSC49_2727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_000145511.1"
                     /translation="MTGETVVYKNEMNLVPLRRFTATEINLFFAMCNKLKEQDTNTLRL
                     SFDELKKLSNYSPETRNINRFANDLDNVYKKMLNLTIRYEDDDVIERFVLFNHYRIHKR
                     EQYLEISTSSNLKHILNSITNNFTKFELKEMTRLKSTYSKNMFRLLKQYKHTGYLKIHI
                     DDFKNRLDIPKSYRMTDINKNVFKPIIIELGSIFNNLTINKIKAKKGRKIEWIEFTFDA
                     EKRIHNKRQPQMSKIDKSRQYVRREKTPKWLEERSYEKQPQKDYDPQLEKEREDFLKQL
                     ELNWE"
                     /name="replication initiation protein"
     gene            18476..18817
                     /locus_tag="CSC49_RS00125"
                     /old_locus_tag="CSC49_2728"
     CDS             18476..18817
                     /locus_tag="CSC49_RS00125"
                     /old_locus_tag="CSC49_2728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761340.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000761341.1"
                     /translation="MKLAEAIKEQRELKGWSQEELANILKVSRQSVSKWESAKNYPSLD
                     ILIAMSDLFGISLEHLIKGDARFKKVILEGNYRESNRVPSIVDFLYDFWWLFFPVAGFL
                     VWAIHSFMG"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(19056..19127)
                     /locus_tag="CSC49_RS00130"
     CDS             complement(19056..19127)
                     /locus_tag="CSC49_RS00130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_106873653.1"
                     /translation="MNEILVHIMTTAISGCLVTLFGY"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            19276..19461
                     /locus_tag="CSC49_RS00135"
                     /old_locus_tag="CSC49_2729"
     CDS             19276..19461
                     /locus_tag="CSC49_RS00135"
                     /old_locus_tag="CSC49_2729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000466619.1"
                     /translation="MFGDQRQEATKYVIKEGYQDIYFLNKNGEWYYFEVRSVWRGKHII
                     RVKDGLLGWRKEIVTE"
                     /name="hypothetical protein"
     gene            complement(19680..20423)
                     /locus_tag="CSC49_RS00140"
                     /old_locus_tag="CSC49_2730"
     CDS             complement(19680..20423)
                     /locus_tag="CSC49_RS00140"
                     /old_locus_tag="CSC49_2730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_000843758.1"
                     /translation="MKSVKRLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESATEDKQKKESDNINFESKSDAQIVEILKNQINTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNAR
                     QNVDAQEKTYTTSPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAQREDVSANPND
                     NDSDIEEKSEETEPKKGFWSRLFGN"
                     /name="DUF536 domain-containing protein"
     ARG             10149..10993
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     BGC             7384..17677
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          1131..1278
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="81.333"
                     /coverage="100.0"
                     /evalue="2.96e-25"
     Typing          17530..18389
                     /name="rep_cluster_2214"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(19681..20423)
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          15878..16152
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="94.565"
                     /coverage="100.0"
                     /evalue="4.71e-46"
ORIGIN
        1 gaataatatc ttagtgcaag cacctagatt attaaataaa cacaaaaaat gtaagcgttt
       61 tattacctct taccaaacta aaattcggaa agaggttttt attatgtcaa ttaaacttta
      121 caacataaat gaggaataca gagaaaagtt ttatcaaata ccgaaagtat tttttacaaa
      181 tcctaaatat atcaagttat ccaatgatgc aaaaatggca tggggtattc ttagagatcg
      241 tttagattta tcaattaaaa atggttgggt tgattctaaa acaggtaata tttattttta
      301 ttacaaaaat gaaaacccac aaaatatatt aaattgtaaa aaagataaag taattaaaat
      361 aaagaaagaa cttaattgaa gccgaattac tactacaaga aagacaaggt ttaaataaga
      421 caaataaact ttatttagtt aaaccagaag taacagaaga tgatatttat aaaattcaaa
      481 agcaagaaaa cactgttgag agcagcaatg gcaaggaagt cggaaaaacc gacttcaaga
      541 agtcgataaa acagaatcta atgatactga acttagctat actgaatcta acaatactga
      601 aataaatgat atgaatgact tgaatgatat agagtccgaa aatgaaatta gtaatcattc
      661 aagtcaatgc aaggttattt aatgcaaaca attttaactg aatttgaaga aacacatgca
      721 ctttatatgc gccgtaaaaa catgaaacaa tataatatct ttaatcaatc attcaaatga
      781 ttttataaca atcaaagata catcaaaata tttcgttaaa tcatctgact ttttaactga
      841 tagcgatgaa aaaatcaaga aattgtcagt gatctagaaa aagatttgta tcgaaaacgt
      901 atgttaagtt atggtggatt gcttaaataa aaacataaaa ttttaaactt agacgatgct
      961 gaagatggca atttaattaa tacaagtgat gaagataaaa tagcaaatga agaagaaaag
     1021 gcacattcga ttacggcaat tttgaaaagc aaaattatta tttaaggcat tagtgataac
     1081 tgatgtcttt ttttattact tttttgtaaa aaaagtgctg tcttattttt gtgacaaatg
     1141 ctgtatgtag tgtcacaaaa gtgtgacact tgagcttttt atgaccccac acaaaaacat
     1201 tttcgaagcc ttgaaatatc tggctttgcc agatccccca ttcattgatg gggacaaatt
     1261 tcccttatgc tcttacggag attttagagt taaattaaaa tttctaagtt tttgataaga
     1321 aaagccctgc aggaatttag aagaacgtgg ggaagtttta aagaatttta tgctaatttt
     1381 taatttgcat gtaaatgggc agtgtctaaa aaatagttat tgtttttgct caaatttttg
     1441 tttttgaaaa tagcatatat ttatttggct catatttgcg ttttaaaagc gtatataagt
     1501 tttagatata aaactatatg aatcacccct aaatctttaa aatgccctct taaaattcaa
     1561 aataagggca taaaaaataa aagccccccc agataaagtg aggtagcttt ttctttcgac
     1621 gccgtatcgt cgatgtaatt caaaaaagtt atgggctata aatctacatc actttttcaa
     1681 gaatgtagta gcaatattca acgcaaatta atttttataa ctgctcggaa tatctcaagc
     1741 cgtttcttta attttgaaat aaaaaaatcg acgaaggtcg attacgtttt tgcacatgtc
     1801 gatttatccg acgtataagt gcgcccttac gggatttaac tagattataa cgacgaattt
     1861 tagacctgta aagcaataac aattaggtct accaggtaga taaagtgtac aaagtagaac
     1921 cgaaaaagtt atttattttg aagatttttc gtagatataa tttgctaata aacttcctaa
     1981 aactgaataa agaaaaatag ttaaactcat gtaatcactc cataattctg aagtgtctcc
     2041 atgtctacgc atagacacgc atttatgccg agaaaattta ttgtgcgttg agaagaaccc
     2101 ttaactaaac ttgcagacga atgtcggcat agcgtgagct attaagccga ccattcgaca
     2161 agttttggga ttgttaaggg ttccgaggct caacgtcaat aaagcaattg gaataaagca
     2221 cctatgatta tttaaaaata taagttataa tacattcaaa aatatttttg aatgaggtgt
     2281 attatgattc aaacggttgt tgctgctgct gttctttata ttgctacagc agttgattta
     2341 ttagtaattt tattaatatt ttttgctaga gcaaagacta gaaaagaata tagaaatatt
     2401 tatgttggtc aatatttagg gtctattatt ttaatattag ttagtttgtt tttagctttt
     2461 gtattaaatt atgttccaga aaagtggata ttaggtttat tgggtttaat accaatttat
     2521 cttggaatta aagtggctat ttatgatgat tgtgaaggag aaaagagagc taaaaaagaa
     2581 ttgaatgaaa aaggattgtc taaattagtt ggtacggttg caattgttac gatagcaagt
     2641 tgtggcgccg ataatattgg tttatttgtt ccgtattttg tgacattaag tgttactaat
     2701 ttattactta ctctgtttgt ctttttaatt ttaattttct tcttggtgtt tactgcacaa
     2761 aaattagcta atatcccagg aattggagaa attgttgaga aatttagtcg ttggattatg
     2821 gctatcattt atatagcttt aggtttattt attattattg aaaatgacac tattcaaaca
     2881 attttaggat ttatatttta atttagggtg tgattttata tgagttatga aaatacttgt
     2941 gatgtgatct gtgtacatga ggataaagtt aacaatgctt taagtttttt agaagatgat
     3001 aaatctaaga aattacttaa cattttagaa aaaatttgtg atgagaagaa attgaaaatc
     3061 atattatctt tgattaaaga agatgagttg tgtgtttgtg atatttcttt gatattgaaa
     3121 atgagtgttg cttcaacttc acatcattta aggcttttat ataaaaatga ggtacttgat
     3181 ttttataaag atggaaagat ggcatattat tttattaaag acgatgaaat aagagagttt
     3241 ttctctaaaa atcaggaggg tttttgaaac gagtgaaacg agtttcttct tgtcttgata
     3301 ctataaaaaa caaagttata taacataaga cgacttatcg gaagttatct atcatcgtat
     3361 attcggagat gatataatat acaggtcgcc tatctctcag gcgtcaattc agacgcagag
     3421 aggaggtgca ttactttgct aatcattttc gttcacatca tagcaccagt catcagtggc
     3481 tgtgctgttg cgtattatac ttattggctt agtaaacgca acaaataatt aataggcgac
     3541 tttataagcc agcatcgaaa aaatccccac actattgcag tagtgtgggg attggtgcat
     3601 taattgttaa tcattttcgt tatctagatt ataacactgg ttagtagagg aatgcaaaaa
     3661 gataatattt taagtagtct ttttggatat tatcatatga tatatttatg taaattgatt
     3721 ttttattaaa ggagcatata tgagtaatac taaaattaaa tatcaaattt ttatttcatc
     3781 aacttattta gatttaatag aagagcgtca agcagtagta gaagcagttt taaacagtaa
     3841 taatattcca gcaggtatgg aactttttaa ctcaagtagt aaaagccaat gggaaataat
     3901 aacacaatgg atcaatgaat cagatgcagt gatattattg ttaggttcta gttatggaac
     3961 aattgatagt gaagaaaata ttagctatac agaaatggag tacaattttg ctaaatcttt
     4021 aggtaaacct atatatgttt ttgagatgaa taaagcatct accgaatccg cggaaaagtc
     4081 taaaaaatta gatgagttta agacaaaagt taaagaaaat agactaatta gtccaaatat
     4141 taatgatatt tcggaattaa aaagtaaagt atctcagact ttaatgcaaa gtgtacctag
     4201 tgaaattaaa gaaaatagtg gatggataag agtacaggat tgtggtaaaa atgtaaaaaa
     4261 attaaaaaaa ttggatgcta tacaaagaga tttagataca tatgattttt tgaaagaaga
     4321 actttataaa atattcatgt atgtaaaaac tttttatttc cagcacacac catttgatga
     4381 tagttatatt gaagatatag aaaactacct gctaaattat gaaaataatc cacataaatc
     4441 attcatgaaa ataaaagttt atgattataa aaacttttta aaacatttaa aaaacatatt
     4501 gattttaatt aaacaaggaa aaaagccatt agctcaagcc ggtcatttta aattaagctt
     4561 ttacgaagag gatttaaaat tgttacaaaa aaattataag actacgctag tcgatattaa
     4621 aggattgaat aaacattttt ataaggaatg tgataggtgc ttaaaagcat ataatatttt
     4681 tattgagggt ataaataaac atttatatga atgatataag tacaccctaa tcatacatat
     4741 ataattgttg tcactttact cgatatatga gaatgacttt acctaataaa tgagaaaagc
     4801 aacgcactat attaaaatgc gttgcttttt ctattatcga atacctataa ctaaactatc
     4861 tctagctgtt tctacaactt ctgtacttat tttatctaaa ccatttatat ccataattct
     4921 gtctatctgc gcaaataaac gatgaatcag cctaaaattc ccttttgtaa ttttaataat
     4981 cgtcgttatt gcctcataat cagtaaagtc ttcgagtttt aaatcaaatc ctaagtcttg
     5041 ccacttatat tctaatatat gatgcgtctc atctttactt agattatcaa attcatgcgc
     5101 aaaacctata cgcgaatata gttgaggata acgagatagt tttttctcta tacccggcat
     5161 accaataaat atcattgcta aattatgttc atcataaata gctcttaatt gctctaaatg
     5221 ttgcacttta aggcgatcaa tctcatctac tataattaaa tcaatatatt taaacatatc
     5281 actataatgt ttactatgtt catgtccata cttatttaca acatgtaatt tttgacccaa
     5341 atcaatgatt gcagtaatac tatataaatc attccttaat ttagtttgtt tttctgctgg
     5401 tgcattataa aatattttat ccaccgatag tatgtcatcg gtcgttttac tagctaaatc
     5461 ttcccaacct ctatggttaa cttgtttttc aatagtatcc caatttgtgt aatacctaga
     5521 cgataaagtt tttccgacac caggttgacc ataacatata ccaatatact gatatttaat
     5581 acaagcatca caaaattcag caaagcgttt atactctttc gtttcaatga aattttgatt
     5641 tttagtcatt acgatatctc tttaattttt tgacgttttt agtcgtttct tgaggtgaat
     5701 aaccacaatt tttttcttcc ttaattaatt ccgtggtact tggactagca atattttgtt
     5761 ttaagtgttt tcttctctga ctacgagcgt gctgtatgtc ttttatatct atggagtaat
     5821 cagctatttc tggacatata gcagtacaaa gaaattcatc tctataaaac acacgtattt
     5881 cagccatatc atttgggtta taacgaatca gtacatattc acctacataa gcttctagat
     5941 tagtattact gtatcgaaaa ccttgaaaat gaatgccatc tgaatgaact tttctagatt
     6001 taggtatttc caacaataat aaatcaagtt gttctaagct acttggcata ttagggaaaa
     6061 agtgattact attccaatga ctgataggcg tggtatgaat agtactatgt tctttttgat
     6121 tataatcttc aattaaaaag taacgtaatt tttcttcaaa attgtgaaaa tttattagat
     6181 tactaggagt atcattattg tttatatatc caggcagttg ttctaagaaa gtttgattaa
     6241 ctgtctgaaa gaatcgttct atttttccac gaccacgagg aacaccaact ttcgaaaaca
     6301 tcaagttaat tttcaaatca atagcgactt gttccatatg atgtgaagta aagtcacttc
     6361 catgatctgt gtagaatttt tcgggtatac cacacactgg ccaattggta tcatttttat
     6421 tccatattgc ttggtgtagt gttaatgctg tgttttgagc attggggggc atcaaaactt
     6481 aagaaatagc ctgcaattgc acgactatag tcatccataa taatagttag ccatggtcta
     6541 ttgatattac ctttttggtc taatataaag atatctagca aagtatggtc tgcttgccat
     6601 atttcattgg gtctcgagga ttctctaatt tgtattaaat cgtacttatt ttgatagtat
     6661 ttttcaccct gatgagagaa atcaataaca gacttaggca tcgctttaat aacactataa
     6721 atttgtttat aacttggtat atcaaaatta ttttctttac agtaattagt gattttccta
     6781 tgaattgtgg ctatactatt tcttttattc ataagcgcaa ggcgttcaat ttcatcaatt
     6841 atctttggtt ctattttacg tgttccttta tcagctcttg tcgcatagat tagtccttta
     6901 agtccttgtt ctttatatga cttattccac ctataaaggg tgcttaacgc aatcccttta
     6961 cttttagaaa tacttgataa agattgttcg cctaggataa aaggttttat aatattgtac
     7021 ttttgagtag cttttttacg tttggcttca gaaaaattag ttagatactt ctccttgttt
     7081 ttcatcttcc ttgtcctcca atttattgag gtaacgataa attgttgtac gtgaaacatg
     7141 ccactgttct gcaattgtct taattggcgt gccattatca taaagggtct taagtaagtt
     7201 taaatctttt tgatttaatt tttctggtct gcctccatat cggcctctag cacgtgctgc
     7261 aattcggcca gctgaagaac gctctaaaat taaattacgt tcaaattctg caaatgctgc
     7321 gaataaatga aataataatt gtccagttga acttgattta tccattgtta tattttcttc
     7381 taaactatgg aaacttacac ctcgttcgtt aagctcatta actaatgtga ttaaatcctc
     7441 catattacgt cccaatctat ctaatctcca aacaacaatc gtatctcctg acctcgcaaa
     7501 ttcaattgct ttatctaaac caggtctttt actttttgaa ccactcatat ggtcattaaa
     7561 tatcttttca caaccatatg tatttaatcg atcctcctgt aaatttaaat tttgtaatcc
     7621 agttgaaact cttgcataac ctattttcaa aatacaaacc tcctatatac atcttcagtg
     7681 taccataact taattacaag gtcttttatg aacatagatt ttttgttggg tttttgaaca
     7741 cataatccta tgtaattctt acttatttag acataaaaga agagtgtaca gaaaatggtt
     7801 attttctgta cactctcatc tttaataata tattttaaat gtcattaaca aaactaattt
     7861 aataagagtc aagcatagtt tacatatgta ttatgtttga aacatacctc taattacttt
     7921 ttactaatat catttaaaat atctcgcaat tcttcaattt ctttgttatt taattcttca
     7981 tttttcgcaa aattcaacac taaacttttc atatcccctc catacagttt attaagaaag
     8041 gttttagcag ttttcatttt aatatcgtct tctttaatat ttgatgagta aaaataaata
     8101 ttttctgatt tgtatcgttt tataatctct tttttatata gtcttgtgat taatgttcta
     8161 atcgttttat cactaacttc tttatatttt tgaatttcaa ctacaatttc attagctgat
     8221 actgattttt tatcccatat tatattcata acatcccatt cagccataga tatttcaact
     8281 tgcttattgg ccatttaaaa cacccattcc ttttaatatt ttttcactta ttaattcagc
     8341 atttttccca gacgggtttc catctgataa atgtgtagca aaataatact tatcatgatt
     8401 tgtaattacg taacctacaa accacccatt attatacttc ccgtttacta tacctgtacc
     8461 tgttttccca tacagttcat acttttcatt tttcttaatc aataatgaag aagataattg
     8521 attctttgct tttttactaa aatggttatt ttgttccatc atatttttaa aaactattac
     8581 ttgttcaaga ttagatattt tcaaactatc ttccatccaa tagcttttat aacttcccaa
     8641 attttcatta ccataattta attgcttgag ttgagccgca gtatagttct ttggtatttg
     8701 attactaata cgttcgaagt accaattaac tgaattttgc attgctgtat ttaaatcttg
     8761 ttccttattc caagactcga aaagataatg tttatgattc catgacatac gtgaattttt
     8821 atcacttata atatgacggt caagtccaaa cagtgctaaa taaattttgt aagttgaatc
     8881 aggagaatat ctttttctac tttctttttc attataaata tagtatttgt ctttcttcat
     8941 gctgtacata acgaaagatc cactatttga accaaaattt ttactttcat ctaaaatttg
     9001 gtaatcgctt tgtaagggct ttttataatt ataatcagtt aaggattgcc ccattaaaaa
     9061 ctggctttga attatcatga taaaaaaagt aaaaatacaa ataaaaatta gaattaattt
     9121 tgactgcttt ttcagatcgg cttcttttat attaattaat ctatttttga gtaatgattt
     9181 tttaccatta aatgaatggc ttaatatatt tttgttgaaa aatgaggttt ttaatacgga
     9241 gtccataata gattccgcat aagttttaaa ttcatttttg ttaatattat taaggacaaa
     9301 tctatcggct tctacttcat tgtcatgaat tatctttctt tttacaatat gtactaatgg
     9361 attgtaactc ataataatag agaagatatt aaagataatt aaatgtaaag tatctctatt
     9421 tttagcatga gcatattcat gcagtattat atattttagt cttttatcaa ttacactttt
     9481 aaaatatgaa ctaggaatca aaataatata tttcccatac caaaaagtta ttggagattg
     9541 aatagcctct gcttttcgaa tcacaatatt ttttttatat tgatggttga aaagtatcgt
     9601 atctatttta tttttttcat tttcgtttag ataaagtgac tgtttcttta aatatttaag
     9661 atataataag gctttcaaaa atttaaaact taaaataata actaaaacta tccaaataac
     9721 tgtgcagata ttatcaattg aatcccaatt aaacttatgg atatctgttg cgaactcttg
     9781 aacaggtttg gtggtaatta tgttatggtt caagtcgtgt gacttacttt caactgtggg
     9841 cgcttgatta ttcacattat taaattttat aaaagagaat ttaattggga taaaaggaat
     9901 taatccagca agcacagtta gataccaaac tttataattt aaactataat taaaatagcg
     9961 ttttaatatg tacctaaaaa atactaacaa tagaaatata aaacaaaagc ttactacact
    10021 cattattagt aatttagcca ttttgacacc ttctttcaaa tatttataat aaacaattga
    10081 catcaatatt acaattgtaa tattattgtt ttgtaaaaat tacaactgta atatcggagg
    10141 gtttattttg aaaaagttaa tatttttaat tgtaatggct ttagttttaa gtgcatgtaa
    10201 ttcaaacagt tcacatgcca aagagttaaa tgatttagaa aaaaaatata atgctcatat
    10261 tggtgtttat gctttagata ctaaaagtgg taaggaagta aaatttaatt cagataagag
    10321 atttgcctat gcttcgactt caaaagcgat aaatagtgct attttgttag aacaagtacc
    10381 ttataataag ttaaataaaa aagtacatat taacaaagat gatatagttg cttattctcc
    10441 tattttagaa aaatatgtag gaaaagacat cactttaaaa gaacttattg aggcttcaat
    10501 gacatatagt gataatacag caaacaataa aattataaaa gaaatcggtg gaatcaaaaa
    10561 agttaaacaa cgtctaaaag aactaggaga taaagtaaca aatccagtta gatatgagat
    10621 agaattaaat tactattcgc caaagagcaa aaaagatact tcaacgcctg ctgctttcgg
    10681 caagacttta aataaactta tcgcaaatgg aaaattaagc aaaaaaaata aaaatttctt
    10741 acttgattta atgtttaata ataaaaacgg agacacttta attaaagatg gtgttccaaa
    10801 agactataag gttgctgata aaagtggtca agcaataaca tatgcttcta gaaatgatgt
    10861 tgcttttgtt tatcctaagg gccaatctga acctattgtt ttagtcattt ttacgaataa
    10921 agacaataaa agtgataagc caaatgataa gttgataagt gaaaccgcca agagtgtaat
    10981 gaaggaattt taatattcta aatgcataat aaatactgat aacatcttat agtttgtatt
    11041 atattttcta ttatcgttga catgtataat tttgatatca aaacctgatt ttccctttat
    11101 tattttcgag atttattttc ttaattctct ttaacaaact agaaatattg tatatacaaa
    11161 aaatcataaa taatagatga atagtttaat tataggtgtt catcaatcga aaaagcaacg
    11221 tatcttattt aaagtgcgtt gcttttttct catttataag gttaaataat tctcatatat
    11281 caagcaaagt gacataattg ttgaatttat agtaactgaa acgtatgatt agggtgtata
    11341 ttaattatga gatggaaatc aatgattgtt ggctatgcga gagtatcatc gaacgatcaa
    11401 aatttagaaa gacaacttga aaatttaaag acgttttgtg ctgaaaaaat atttacagaa
    11461 aaacagtctg ggaaatctat tgaaaataga ccagtacttc aagaagcact taactttttg
    11521 aggatgggag atcggtttgt agtagaatcc attgattgtt taggtcgtaa ttatgatgaa
    11581 gtgattcata ccgttaatta tttaaaagac aaagaagtac aattaatgat tactagctta
    11641 cctatgatga atgaagtggt tggcaatcca ttactggata agtttatgaa agatttaatt
    11701 attcaaatat tagcaatggt ttcagaacaa gagagaaatg aaagtaaacg tcgacaagcg
    11761 caaggaattc aagttgcgaa ggaaaaaggc gtatataaag ggcgcccctt actttattca
    11821 ccaaatgcta aagatccaca gaaacgtatt atttatcatc gcgttgtaga aatgttagaa
    11881 gaaggccaat caattagtaa aattgcgaaa gaagtaaata taacaaggca gacgatttac
    11941 agaattaaaa acgataatga tttgatttaa taaactttgt ttcaatgcaa ctgagagctt
    12001 ctcacagcgt ctcaaaacag atgattataa tctattatga gtttttaata ataagacaag
    12061 aaaagagagc gtaaatatgc tctctctttt tctcattaac gaatgtttat aacgcaatca
    12121 tgatgagagt attaatacag ttaattattt gaaatacttt agtttatata atgttgaatt
    12181 ataggtagtg aaattgtatt tattatacat tgtcatatcg ttgtttaatg atagttaatt
    12241 taaggataat agaattaata ttatatatag atgaacaaaa caagcaacag agcagaaaaa
    12301 acacttttag attattttta ctcattctct attttattta tttttgctat aataaataaa
    12361 gaatattaaa tggaggtgtt tttatgaaaa agaaatttgt ttctagttgt attgctagta
    12421 caatcttatt cggcacttta ttaggtgtaa cttataaagc tgaagctgca acagtacatg
    12481 tagctggtgg tgtttggagc catggtattg gaaaacatta cgtatggtct tattatagtc
    12541 acaataaaag aaatcatggt tcaacagcag tagggaaata ttcatctttt agtggtgttg
    12601 ctcgacctgg tgttcaatct aaggcatctg ctccaaaggc ttggggtgga aacaaaacat
    12661 tttatagtct tcactaatta catatattaa ttaaggagaa tagacagaat taagtaaact
    12721 taattctgtc tattctcttg aaagaggcaa tatgaaaaaa ttcaaattat ttttagattt
    12781 tagtacttta ttattaattt cagggctatt atttttattt ttcttcaaag aaaatgaaga
    12841 aattatacct gaaagttcca atattttaac aatctctaat tgggataaat ctaacagtaa
    12901 atcaaaagtg ttagatgtca ttgaatcagg cgccaaaaat caaaatatac aaataattaa
    12961 atccgttaaa gattttgata ataaaaaaga attttttgtt ttcaactcaa aacgaaataa
    13021 ttctgacttt atacgtaata aaacatcact tttaactcca tcagatttat taaacagaga
    13081 gataaaagga aagtattata ttattggtga acatttcaat gtagaagagc ttacgagtga
    13141 attaaaaaaa gctggtttaa catctgaagt tgaatacata aatagaaaca tattattttt
    13201 tgaattagtc atagataatg atttattagt gcctttcata ttcttaggcg tattatatct
    13261 tttgtacttc ttatatgaca gaggatataa tttgaaattt tatgctattc aaaagctaca
    13321 tggcttttca actacacgca ttatttttca taatattcat ataaaaatca tttattggct
    13381 agtacttacc gctattttct ttattgctaa tatattaatc attcatatag ccaatttaga
    13441 attggatttc ttaatgttta ttcgtagatt tatcgtgttg ctttttgttt ttgcttgtat
    13501 tactacattg ctgtggctga tttcgtatag tcttcttttg aagttaagta ttccattaat
    13561 cttaaaaggg aaaaaaggat ataagttttc aatatttatg ggtaccttca ccaaatgtat
    13621 catggtgcta atactatctt ttttactggc acaaaattta aatgcttata cgaagttaaa
    13681 gaatatatat gactctgaaa aaatctggca aaagttagat aattactata cattagagat
    13741 ttctcctaat attagaaatt cagaagaaaa acaaatttta gaaactaata tatacaattt
    13801 aattaagaaa agcgaacaac ttggtggatt gcttttaaag aataataata tagccaatcc
    13861 cgataaaaac aattacattc ctgaaaatgg caatgtcttt tttatcaata acaattttct
    13921 gaatttctat aaaaatataa atcatgattt taaaatgatt gacaatcatt cggataaaat
    13981 aaacgtgttt attcctccaa ggttacaata tcaaaaatct gaaattcaaa aaaatcacca
    14041 aggatggatt gactttcaaa agcaacaaaa caaaaaagta gatgtgcaag tactgtcaaa
    14101 aaacgtatct gttttttctt ttgatcgcac aactaatttg aaatttgggt atctagattc
    14161 tccaatagta atgttgttga cacttgacga tttaacagga gatttttatt tagctgctgt
    14221 ttctcaaggt ggatatctat ttaaagattt agatacactt aaacagttgc ttaaagataa
    14281 tcacctagaa gaagaaatta gcggtataac taattacaag gattctgtgt taaatgaatt
    14341 aaatgaaacg aaaacaaaaa tgataataac aatagttact attattatta acgttttcat
    14401 tcttttgata gctactgtat ttgaaacaat tcaatatttt agctggaata aaaagcaact
    14461 attattaaga aaaattcatg gttattcatt attcagcagt aatgtacgtt atttaacaat
    14521 ttctatctta ctttctatta tgttagctta cactacgcat attttatttg gttcaaagat
    14581 attactattc ataataatgt ctattgctat tattcaacat ttacttcaaa ttgcttatat
    14641 taaatatctt gaaaaatact ttaaagattt aatgagggag atttaaacaa tgaaaagaac
    14701 tttaattatt gtaacaattg tactattaat catcatactt agtctgttat tggttagaaa
    14761 tgagcattta gatcgtttta acccactgtt aaaagaaaaa gtatcttatg ccaaagttcc
    14821 aaaagatacc caggactata gaaatataac tgtatactct aaaaatggag aaaaaaagag
    14881 ttataaattg gattttttag gttatgatcc tacaaaagaa tatgtgaaag taaatcataa
    14941 agggaaatat gtgcgttcga tagaatacat tacaaaagat attcctagct ttttaaaatg
    15001 aggtgaccga tagtgataaa acttgaaaat gtttttgtaa aaaaaggtaa taaaaacatt
    15061 ttagacggat gtaactttaa ttttgaaaaa ggaaaatcat atgctttagt tggagaaagt
    15121 ggcgctggaa aatctacttt acttaacata atcgctgggt tcgaagatgt atcacaagga
    15181 agcatatata ttgaagataa gttactaaaa aagaaagtcg atttttatag atatacgtta
    15241 gggtatttgt ttcaaaattt tgctttactt gaaaatcaaa caatcagtca aaatttagat
    15301 ttagccctaa agttcaaaaa gaataaaaaa gataatatga acttaaagaa agaagtatta
    15361 aaaaaggtcg gcctagattt agatatcaag agaattgtta gttctctaag cggtggtgaa
    15421 caacaaagag tagcattggc aagattaata ttaaaagatc cgaaaatcat tttagctgat
    15481 gaacctactg ggtcactaga tacgaaaaat ggaaaaatag ttattgattt attattgaag
    15541 ctacttgatg aaaataaaac tatgattgtc gtaacgcatg atttagagct tgcgaaacga
    15601 tttgatgtca tagtcaatat ttctgagctt agaagttaag aaatattgat aggtatagcc
    15661 atacatagag aaaaaacaat atgaaatatg attagtcatt acttttgagt tttttaattt
    15721 aaggactgga ttttccagtc cttttttatg atgacaaaaa acaagcctcg cagagcacac
    15781 gtttttaatg acttatttgg tttttaataa gtctagtatg ttaaaacttt tctgtgttta
    15841 ggtgttataa tcatatgcag tggaagttga tttattatgt cttattcaat tattcgagtt
    15901 gttaaagtga aatcaaaaac aaatacaaga ggtattcaaa gacatattca aagagaaaat
    15961 aaaaattatg aaaatataga tattgattta agtaagtcat atttaaacta tgatttagtc
    16021 aatgatacta agtttgattt taataaaaaa attgatgaga aaatcgaaaa aaattataaa
    16081 gggaaacgca aaattagaac agatgccatt aaacatattg atggattaat tacatcagat
    16141 aatgtgtttt ttaatcaatt atctgaagaa gagacaaaat agttttttaa gcatgctaaa
    16201 gcgttcttgg aagaagaata cggtaaagaa aatcttttat atgcgacagt acatatggat
    16261 gagataacac cacatatgca ttatggcgta gttcctatta ctaaagatgg acgtttaagt
    16321 gcgaaagaag ttgtaggtaa taaaaaagca ttaaccgaat tccaagatag attcaatacg
    16381 tatattaata agcaaggcta tgatttaaaa cgaggaattt ctagacaact tacaaaagaa
    16441 aaacatgatc aagttagccg ttataaacaa aaaacagaat atcataaaca aatgcatatg
    16501 cgctagaagc aaatagagga ttatttaaag caagaaaatg ataaattgat acaaaactac
    16561 caaaaatcat tagatacgct taaaaagctt ctgagtgtca tgtatgaaat taaaactaaa
    16621 aatgtaggtg gatggtttca taaagagaag caagaaacag gcaatattgt aattactaaa
    16681 actgattttg aaaaatacac taaacaaatt aaagcagcac agatgatatt agatgattat
    16741 gaatgtatta aaagtgggaa gtcattaaaa aaagcagaga aacaaaatga aagtttagtt
    16801 aatgaattga ctagtgtcca tatggaaaat gaaaagctgg ttgaagaatt taatgattta
    16861 gcacaacgtt ataattattt gttgtcagag aatgaaaaga aagataaaga actaaattat
    16921 acgcttaagt tattcaatca agtttttaaa atcattaaaa gtatgatgaa agaagagcgt
    16981 tatcatacac taataaatca tattgataat catttagaca attctaaaat acgtgaagta
    17041 atgacgatag ataacaatga tgaacagttc tttaagaaga aatatcaagc acaagaacga
    17101 gaaatcattt ttaaagaaga tagagaagat ggttatacat tataaaaata gatatttaaa
    17161 tgcatttgtt tgaggttaat tattttttag gatgaaaaat aggtagcccc cctcgaactt
    17221 tttaatatat ttttataaat ctttttaaaa acctttttag gggcttgttc agccctagag
    17281 caacaaggga tttcaatgcc taaaggagtg tttttgccac ataaaaggag tgtttttgcc
    17341 acataaaagg agtgtttttg ccacataaaa ggagtgtttt tgccacataa aaggagtgtt
    17401 ttaaaaagtt gtactccttt tatggtttga cattgataat aaagtagttt attgtgaata
    17461 aaagttttca aatgggagtg tatattcaaa cgatactcct ttaggttcgt aataaagggg
    17521 gctgtatcat gacaggagag acagttgtat ataaaaatga aatgaattta gttccattaa
    17581 ggcgatttac agctactgaa attaatttat tttttgcgat gtgtaataaa ttaaaagagc
    17641 aagatactaa tacattacgt ttgtcttttg atgaattaaa aaaattaagt aattatagtc
    17701 cagaaacacg taatattaat agatttgcta atgatttaga taatgtgtat aaaaagatgt
    17761 tgaatttaac cattagatat gaagatgatg atgtaataga aagattcgtt ttattcaatc
    17821 attatagaat ccataagcga gaacaatatc tagaaatatc aacttcttca aatttaaaac
    17881 acatattgaa ttcaattact aataatttta caaaatttga attaaaagaa atgactaggc
    17941 ttaaatctac atattctaaa aatatgttta gattacttaa acaatacaaa catacaggct
    18001 atttaaaaat tcacatcgat gattttaaaa atcgtttaga tatacctaaa tcttatcgta
    18061 tgactgatat taacaaaaat gtttttaaac ctattattat tgaattaggt tctatattta
    18121 ataatcttac tatcaataaa atcaaagcga aaaaagggcg taaaattgaa tggatagagt
    18181 tcacatttga cgctgagaaa cgcattcata acaaacgaca acctcaaatg tccaagatag
    18241 ataaatcaag acaatatgtg aggcgtgaaa agacgcctaa atggttagaa gaacggtcat
    18301 atgaaaagca acctcaaaaa gattacgacc cacaattaga gaaagaacga gaggattttt
    18361 taaaacaact tgaactgaat tgggaataac gcaacttttc gttgcgagtt ggttaactaa
    18421 aagtatcgtg acttttcaat tattttaatt atagtttgag ttaaggagtg attttatgaa
    18481 attagctgaa gctataaaag aacagagaga attaaaagga tggtctcaag aggaattagc
    18541 caatatatta aaggtttcca gacaaagtgt ttctaaatgg gaaagtgcca aaaactatcc
    18601 ttccttagat attttgattg ctatgagcga tttattcgga atctctttag agcatttaat
    18661 taaaggagat gcacgtttta aaaaagttat tttagaggga aattatagag agagtaacag
    18721 ggtaccttcc atagttgatt ttctttatga tttttggtgg cttttctttc ctgttgccgg
    18781 atttttagtt tgggccattc attcgttcat gggttgattt taaaatcaaa atttaatgca
    18841 catcaggcaa tatgaaaaag gaaagtattt ttacgacacc ttgaaatgta ttgataagaa
    18901 tagaagagtt tacaaaaggc aatatgaaat atatactaaa agtaacaaga atttcgtttg
    18961 taaacgcaca aaaccccgaa ctattcgccg tagttcgggg ttttttggtg aattggcttt
    19021 aatcgtctat attatttttt atcacgttta tggagctaat aaccaaataa cgtaacgaga
    19081 caaccactga ttgccgttgt catgatgtga acaagaattt cattcataaa tcgcacctcc
    19141 tctctacgcc gaattgacat ctgagagata gacgaccttc acattataac aaatctctcc
    19201 ttccatgaaa taacatgaat attaataaat gttgttatat attaaagata aataaatata
    19261 agggtgggat tgataatgtt tggcgatcaa agacaagaag ctacaaaata tgtcattaaa
    19321 gaaggttatc aagatattta tttcctcaac aaaaacgggg aatggtatta tttcgaagta
    19381 agaagtgtct ggcgtggcaa acatattatt agagttaaag atggtttgtt aggttggaga
    19441 aaagaaatag taactgaata aagatacaaa atacttgcca atgcaaaaga atgaaaacgc
    19501 gtcaaatcaa cgatgtataa aagatgcata aaagataatg aaagtaaaaa gccataaatg
    19561 ccgtcatata ggcatttatg gctttttgtt tggttaacat aatcgatgat tatcagaagt
    19621 tcaattcaca taaaaaagca cggctaattt atgaacttgt cgtacctttt taattaaaat
    19681 tagttaccaa atagacgact ccaaaacccc tttttaggtt ccgtttcttc actcttttct
    19741 tctatatcac tatcattgtc atttggatta gctgaaacgt cttctctttg tgcttcttca
    19801 ccttgtgtac tttcgtcgct ttgacttcca gatatatcct tatattgaat ctctgtttct
    19861 ttagtttctt cctgatctcg gttaatattt acaggactag tagtatatgt tttttcttgt
    19921 gcatcaacgt tttgtctagc gttagtagat gtatcaaagg gataattaag gtgtttttct
    19981 ttttctaatt gattttctaa tttttgaatc tttttattac tctctaatgc cagaacttgc
    20041 tgattctcaa gcaattttga tctttcttgc aactcttttc tgtaaaattc aattgttgtt
    20101 tcatgacgac tttcttgttt ttcaatttga ttatttaaag tattaatctg atttttaagt
    20161 atttctacta tttgagcatc gcttttagat tcaaaattaa tattatccga ctcttttttt
    20221 tgtttgtctt cagtagcact ttcaaaacca tatttctttt tattttcatt tactctttga
    20281 atgatttttt ctatatcggt atcttcttta ataaacgaag tgttttcctg ttttattgtc
    20341 tctatattca atctcttaat attattaaaa atcgtttgct tactaacccc taattcttca
    20401 ctcaaccttt ttacactttt catatcatca accctttata aaatgtttat aaacccttag
    20461 taaaatatta taagcttata acgattaata ataaagtaat cgacaaataa aaatataaat
    20521 tcgccaacct ttttatcaag ggtttgtaaa gggtttatgg tgtttatcaa aggtttataa
    20581 acctatattt tccctttttt aagtttattc aaagtgctat aataacctta atataacaaa
    20641 aaccccaact actggtaata gtcggggttt ggtaataaaa cgtttagaaa ctgtttattt
    20701 atataatttt cgatacttag attatataat
//
