LOCUS       NZ_CP026223            18892 bp    DNA     circular CON 17-JAN-2024
DEFINITION  Aeromonas sp. ASNIH3 plasmid pAER-3367, complete sequence.
ACCESSION   NZ_CP026223
VERSION     NZ_CP026223.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN03455983
            Assembly: GCF_002903405.1
KEYWORDS    RefSeq.
SOURCE      Aeromonas sp. ASNIH3
  ORGANISM  Aeromonas sp. ASNIH3
            Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
            Aeromonadaceae; Aeromonas.
REFERENCE   1  (bases 1 to 18892)
  AUTHORS   Weingarten,R.A., Johnson,R.C., Conlan,S., Ramsburg,A.M.,
            Dekker,J.P., Lau,A.F., Khil,P., Odom,R.T., Deming,C., Park,M.,
            Thomas,P.J., Henderson,D.K., Palmore,T.N., Segre,J.A. and Frank,K.M.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
            Bacterial Plasmids Conferring Carbapenem Resistance
  JOURNAL   mBio 9 (1) (2018) In press
REFERENCE   2  (bases 1 to 18892)
  AUTHORS   Segre,J.A. and Mullikin,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-JAN-2018) NISC, NIH, 5625 Fishers Lane, Rockville, MD
            20852, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 225x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/17/2024 09:06:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,802
            CDSs (total)                      :: 4,644
            Genes (coding)                    :: 4,540
            CDSs (with protein)               :: 4,540
            Genes (RNA)                       :: 158
            rRNAs                             :: 11, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 11, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 122
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 28 of 104
            Pseudo Genes (incomplete)         :: 77 of 104
            Pseudo Genes (internal stop)      :: 3 of 104
            Pseudo Genes (multiple problems)  :: 4 of 104
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP026223.1.
            Bacteria available from Karen Frank, Department of Laboratory
            Medicine, National Institutes of Health Clinical Center.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..18892
                     /organism="Aeromonas sp. ASNIH3"
                     /mol_type="genomic DNA"
                     /strain="ASNIH3"
                     /db_xref="taxon:1636608"
                     /plasmid="pAER-3367"
                     /geo_loc_name="USA"
                     /lat_lon="38.984652 N 77.094709 W"
                     /collection_date="2014"
     gene            complement(join(18727..18892,1..173))
                     /locus_tag="C2U39_RS22625"
                     /old_locus_tag="C2U39_22630"
     CDS             complement(join(18727..18892,1..173))
                     /locus_tag="C2U39_RS22625"
                     /old_locus_tag="C2U39_22630"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_034008300.1"
                     /translation="MKLRNSFPLAAVAALLMASTAHAGQDADAARFSIMAPVQAAYDAY
                     QVTASRAQNTMDSIEAELREPGLSAERRELLAVSLATLRAREAAALERLHAESALAQLK
                     MADWNASR"
                     /name="hypothetical protein"
     gene            complement(270..1175)
                     /locus_tag="C2U39_RS22630"
                     /old_locus_tag="C2U39_22635"
     CDS             complement(270..1175)
                     /locus_tag="C2U39_RS22630"
                     /old_locus_tag="C2U39_22635"
                     /inference="COORDINATES: protein motif:HMM:NF012318.4"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]; GO:0008236 - serine-type peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine protease"
                     /protein_id="WP_099533779.1"
                     /translation="MKAQTWRRAALAAYILAGASLTVAGYTVATTEANANALYRFAEHD
                     NDAYSARSRSIAEGITAAALRGQGDGVPDAADWPRIIPQVIPSAVNVAALPFVTRPDNE
                     SRVWLVPGVQSNPATATLGAVRFWLKSRDQEPRHWQTIGSGAFIADGRYVLTAAHVIDG
                     KSGYRVQTAAGRWLDAELIGLDLRRDVGVLRVSEPGQPIKTGAMPIQGQPVLTIGAPGG
                     RGFSVSAGIVSRYAESARFSADEALQIDAPVTGGNSGGLVVSARGEAVGVVSHSDAAFT
                     QAVPIGTALAVATELIERSR"
                     /name="serine protease"
     gene            complement(1172..1393)
                     /locus_tag="C2U39_RS22635"
                     /old_locus_tag="C2U39_22640"
     CDS             complement(1172..1393)
                     /locus_tag="C2U39_RS22635"
                     /old_locus_tag="C2U39_22640"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_099533781.1"
                     /translation="MATCNVTGGTRRDLTKYRITFALSLAVLIGTGGMFWHAYRTHAGW
                     LNSGDVAVRDAIMDGTIQPPADGKEGAR"
                     /name="hypothetical protein"
     gene            complement(1466..1855)
                     /locus_tag="C2U39_RS22640"
                     /old_locus_tag="C2U39_22645"
     CDS             complement(1466..1855)
                     /locus_tag="C2U39_RS22640"
                     /old_locus_tag="C2U39_22645"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_096035842.1"
                     /translation="MSTEPTNEELAKSYATKIEQAQERREAKDQERLERHGQAAALASQ
                     NIEAEQPQAKQAQGFELDAQNQDSAEQRNDRNEINGQQAKTLAKELNRDNENGDQVKQA
                     RAREIAERFKEKAARDREQSRSFSR"
                     /name="hypothetical protein"
     gene            complement(1948..5283)
                     /gene="traA"
                     /locus_tag="C2U39_RS22645"
                     /old_locus_tag="C2U39_22650"
     CDS             complement(1948..5283)
                     /gene="traA"
                     /locus_tag="C2U39_RS22645"
                     /old_locus_tag="C2U39_22650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020750535.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Ti-type conjugative transfer relaxase TraA"
                     /protein_id="WP_099533783.1"
                     /translation="MAIYHLNTHTIGRAAGHSAVAAAAYRSASSLVDERTGEAFDFTRK
                     GGVLSSEIVTPEGVPVPERAALWNAAEAAEKRKDARVAREWRAALPHELNDADRKELAT
                     RMGQAIADRYGVAVDVCIHAPDKDGDDRNFHVHMLATTRTIGEDGTLGAKAVIELANKD
                     RQKAGIPGTSQGDITDIRRQWAELTNEALERAEISARVDHRSYADQGVELTPTKHIGRD
                     AVAMDRRGLDADRIDIHNADRQEQAQQITERPEIILDKITATQAVFTRRDIAAELNRYI
                     DDADQFQGLLTRLENSPLLVEMEPASGREPAKFSTREMIDTERGMVDSAERLAQAGRHG
                     VSSPITNAAIDGAGTLSTEQQNAVRHVLKPGSLAVVIGDAGTGKSFSMKVAREAWQAQG
                     LNVRGAALAGKAADELQAGSGIDSRTLASLEFAWKNGKDKLTSRDVLVIDEAGMIGSRQ
                     LGRVLKSAEQAGAKVVLLGDDKQLAAIEAGAAFRGVVQHVGAAEITEVRRQKEAWAREA
                     GQQFARGSVADGLAAYAERGHVQIHDSRDAARDGLAAAYVGDQGKGSQIILAHSNKDVQ
                     ALNEAVREARKERGELRGTARFMAERGGREFAPGDRIVFLKNDRDLGVKNGTLGTVERA
                     EDGSLAVRLDSGEARQVQASQYAAVDHGYAVTIHKAQGVTVDRAYLLATPGMDRSLAYV
                     GMTRHREAATLFAGADDFTDRRAGRLVDHGAAPYENKPENRASYFATLENDKGERHTIW
                     GVDLERAIASSGAKRGDRIGLEHGGSETVRLPDGTTAERNTWHVRGAAELAAGKLAQVL
                     GRERPKESTLDFADRRGFDGESVVRRWLERGRAKVSALAGKMRDALRRNLERHGRPDLM
                     PATDIAGKPTMQRPEQIERTPEDEKKRRAAEIAAKFRQQVSQERGEVAAPQQRPQAERP
                     APDPLAGFRAGIERAEAAGGGLALDVARAQLAVAQEFQAAGKDPRHHSAAIMQEGQQRA
                     FAGLAQQGQAKAEPERPAPVQVSEQARKVAEGQARQEVSRFKTLAAGRRNNIAGFTDRS
                     PSKWQALPGELRERIERFNAMPEQRRAVELDKMQNELAERYARDPRAAQRDREQSRQRD
                     GYSR"
                     /name="traA"
     gene            5476..5727
                     /locus_tag="C2U39_RS22650"
                     /old_locus_tag="C2U39_22655"
     CDS             5476..5727
                     /locus_tag="C2U39_RS22650"
                     /old_locus_tag="C2U39_22655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020750536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraC family protein"
                     /protein_id="WP_082380654.1"
                     /translation="MARKTLSERKADKLAELNRIKSELADLENKAAEKIGKIAIAAGLG
                     DLEIDDAQLRKEFEAIASKFRKSEGKQAASVAATPSAD"
                     /name="TraC family protein"
     gene            5750..5971
                     /locus_tag="C2U39_RS22655"
                     /old_locus_tag="C2U39_22660"
     CDS             5750..5971
                     /locus_tag="C2U39_RS22655"
                     /old_locus_tag="C2U39_22660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004167351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein TraD"
                     /protein_id="WP_021011916.1"
                     /translation="MNARREDARRKIQLGGLVIKSGMADYPASVILGALTLAAGALKGP
                     NADATKARFEAAGDEAFSDDGEDGGNRS"
                     /name="conjugal transfer protein TraD"
     gene            6005..8530
                     /locus_tag="C2U39_RS22660"
                     /old_locus_tag="C2U39_22665"
     CDS             6005..8530
                     /locus_tag="C2U39_RS22660"
                     /old_locus_tag="C2U39_22665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020750538.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretory system conjugative DNA transfer
                     family protein"
                     /protein_id="WP_103261209.1"
                     /translation="MMDVKDLLSRMWAAVVAVFFGVFVLSLANTAHARVFPECNPAAEA
                     AKFYGAEDVDAWVKRVCDAQETAFQTWETNLQKLDIGQQDLSMATNAGNWQAYRDKWAE
                     LLPVLKELEAAAVANRNAPGAANILSLYRNDLGLFLQNSGLASAGSLDDFSARILAGLD
                     GERPAAAATAGVNVVQQSVTRGIEFGKGVGTAEADKVLAEYRGQMEQRTAERMEQLGGS
                     TMGGYFGGFGTRIKAAFGGWLFYLVTVCFIGAWMAHKRRQNPVTVGTAVGLAFLVPSVG
                     MLLLLVFAPFIPGWFILAATVAGTVATYLNAGRVFGWLAGVVGAESPTGKRLRILGGTI
                     ENLRGQVQPSGPVAAAGAAAAAVDNSSTHPLGSHGSARWGTVDEIRQGGHLVAPGKPGG
                     FALGRVPDALAGMDARFRFVGHVVTVAPTGSGKGIGAVIPNLLDYPGSALVLDVKGENA
                     AVTARARRALGQAVYSVDPFAVNGDGGAAFNVLDRLDVWNPDCVSESAILADALVIAES
                     KGDAVHFDESAKNFLQGLMLHVAGLDDAERRNLGELRRLLTAGESEFFDVLGAMAADDT
                     AAFGIPARAANTLMGMADKERGSVLSTARRNTAFLDDPRIAAALSRSDFDLSEIKATAM
                     TVYLVMPANRIGPNARFLRLFISSVIAAITSSNVQPAHRVAFLLDEFGQLGYMKQIEDA
                     VSLLRGYGLAFWVFIQDLSQLKGTYPKWQTFLANSAKSFFGTDDYDTAKYISDSLGKAT
                     IEFETENTGKNSGSGLSGGGGSMNRGKSTGTSQQFTGRELLTPDEVMRLGPEHPIVLVR
                     GERPYLLDRLNYLADSEYAGRFDANPYHS"
                     /name="type IV secretory system conjugative DNA transfer
                     family protein"
     gene            8541..8945
                     /locus_tag="C2U39_RS22665"
                     /old_locus_tag="C2U39_22670"
     CDS             8541..8945
                     /locus_tag="C2U39_RS22665"
                     /old_locus_tag="C2U39_22670"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_099533788.1"
                     /translation="MAFIIAAVLGVIALAWFLRRLFPALFAAVFVLFAPVWLVGGALLD
                     LLRRPLAFLRPVGLALARLVGFVLVLPLLPFIFVWSFFAELWRQFRPSKASAPAPAGVK
                     PPTPMQAATKRTADVIDLAAWRRHNDGNAE"
                     /name="hypothetical protein"
     gene            complement(9080..9970)
                     /locus_tag="C2U39_RS22670"
                     /old_locus_tag="C2U39_22675"
     CDS             complement(9080..9970)
                     /locus_tag="C2U39_RS22670"
                     /old_locus_tag="C2U39_22675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020750540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="WP_099533790.1"
                     /translation="MTQQAPQIPADVRERIIAAAADLFEQSGRQTMPTVDAVRRAARVD
                     MNAASAVMKEWRRAQTAQAAPVAVAVPESVQQASSAAVAAIWQQAQELANESLRSAQAA
                     WETERVEQDAMRQELAEAFERQAGELEALQSRLASIEAAEAAARGEAAELRGQLAAAQE
                     QAHTAEARAQEIERRAGELRTELDRAHQTSQAAAAQLDQVRGELAKVQAKAEADQDAHQ
                     EQRKAAAAEAHRIAERLTAAQAERDQATKAAGQAREEAARMAGQIDTLKEQSAALLARI
                     TPAEAKPTRKNPGGE"
                     /name="DNA-binding protein"
     gene            complement(10369..10575)
                     /locus_tag="C2U39_RS24380"
     CDS             complement(10369..10575)
                     /locus_tag="C2U39_RS24380"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_158657364.1"
                     /translation="MEKTDRQREPNHRNALRARLPSGRFAPFAPPLRVGLSNGWPAARH
                     LPGAARRAGASSTACAHIQHRAR"
                     /name="hypothetical protein"
     gene            complement(10878..11894)
                     /locus_tag="C2U39_RS22675"
                     /old_locus_tag="C2U39_22680"
     CDS             complement(10878..11894)
                     /locus_tag="C2U39_RS22675"
                     /old_locus_tag="C2U39_22680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016851360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein RepA"
                     /protein_id="WP_099533763.1"
                     /translation="MNKKRDGQEAQQIGDILGGLIVKAQAKAEAKTRKPRAGAKITPAG
                     IILTEQDQKLIEAGAEIATNPPSGEDMAFTHAVLCQVGLPRSKVEGREFMRQSGAAWVN
                     VQAGYLDEGKGPVLQPIPYGVMPRLALAWVSSYAKRDNTREIPIGDSAAEFLRLMGMDD
                     QGARYTTLRRQMHALAACRLQLGFKGRTYNGQPVEQFDAWLANGDAQQKSLWPGTMVLS
                     EGYFNSLMDSAVPLDNRALMALKGSALALDVYTWLAHRLHRIEGRGVTLHWKSLREQFA
                     QEYTGKDADKDFKKKFVPALKKVLTVYPQAKVKPVTGGLLLLGSPPPIAPKSGGKFS"
                     /name="replication protein RepA"
     gene            complement(11958..12227)
                     /locus_tag="C2U39_RS22680"
                     /old_locus_tag="C2U39_22685"
     CDS             complement(11958..12227)
                     /locus_tag="C2U39_RS22680"
                     /old_locus_tag="C2U39_22685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005933773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribbon-helix-helix domain-containing protein"
                     /protein_id="WP_099533765.1"
                     /translation="MAIQRKPKTGPAAAEDAFIQGAPDAKTEATPAAVYEKGIAKGNKR
                     QITLTISPELLRKVDEVAKRTGQARAAIINMAIFNALEGNIFQS"
                     /name="ribbon-helix-helix domain-containing protein"
     gene            complement(12242..12901)
                     /locus_tag="C2U39_RS22685"
                     /old_locus_tag="C2U39_22690"
     CDS             complement(12242..12901)
                     /locus_tag="C2U39_RS22685"
                     /old_locus_tag="C2U39_22690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007425125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WP_099533767.1"
                     /translation="MIITVGNTKGGVGKTTLAVQIAIARALAGRDVWLIDGDRQGTAAA
                     AIAARAEAGRQPGIACAQYADGPALRGQVQQQRDKWQDIIIDAGGRDSTALRAALVLSD
                     VLLVPFAPRSYDVWALDDMAALVDEARSVRDGLRCYAVMNQADPGEHSADNADAAAAVA
                     EVPQFEYLPTPIRRRKAFSNAGGAGLAVAELAPRDPKAIAELDSLVASLFNIQKIA"
                     /name="AAA family ATPase"
     gene            complement(<13291..13872)
                     /locus_tag="C2U39_RS22690"
                     /old_locus_tag="C2U39_22695"
                     /pseudo=""
     CDS             complement(<13291..13872)
                     /locus_tag="C2U39_RS22690"
                     /old_locus_tag="C2U39_22695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017166843.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /name="recombinase family protein"
     gene            complement(14009..14392)
                     /locus_tag="C2U39_RS22695"
                     /old_locus_tag="C2U39_22700"
     CDS             complement(14009..14392)
                     /locus_tag="C2U39_RS22695"
                     /old_locus_tag="C2U39_22700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009238015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_031943200.1"
                     /translation="MSRKQSSAFVTTRKGFCYLTVKVGRSNFNIMRIRSYTITPQDKRD
                     MRRLYPDHLFDWKKIGQQLAEKREVCRAYRSKRQAPRSTERTPDQFVMVSYDSGTRTVY
                     ASDACDSMALLDAVLHMERARKK"
                     /name="hypothetical protein"
     gene            complement(14389..14952)
                     /locus_tag="C2U39_RS22700"
                     /old_locus_tag="C2U39_22705"
     CDS             complement(14389..14952)
                     /locus_tag="C2U39_RS22700"
                     /old_locus_tag="C2U39_22705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017160511.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_058165502.1"
                     /translation="MALIGYARVSTAEQDTALQTDALHKAGCERVFEDTASGAKADRPG
                     LADALAYLRDGDVLVVWRLDRLGRSLPHLIETVGKLEARGVGFRSLTENIDTTTPGGRL
                     IFHVFGALGQFERDLIRERTKAGLTAAAARGRKGGRRPVVTADKLQRAREHIANGLNVR
                     EAATRLKVSKTALYTALQGGSEQR"
                     /name="recombinase family protein"
     gene            complement(15167..15448)
                     /locus_tag="C2U39_RS22705"
                     /old_locus_tag="C2U39_22710"
     CDS             complement(15167..15448)
                     /locus_tag="C2U39_RS22705"
                     /old_locus_tag="C2U39_22710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013521176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system YafQ family toxin"
                     /protein_id="WP_060986098.1"
                     /translation="MRTIDRSSAFKRDFKREAKGQHRATLDDALKPVLLALATDQPLDA
                     RHRDHDLSGDWAGYRECHIKPDLLLIYRKSDSDTLRLARLGSHSELFG"
                     /name="type II toxin-antitoxin system YafQ family toxin"
     gene            complement(15435..15704)
                     /locus_tag="C2U39_RS22710"
                     /old_locus_tag="C2U39_22715"
     CDS             complement(15435..15704)
                     /locus_tag="C2U39_RS22710"
                     /old_locus_tag="C2U39_22715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012536625.1"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelB/DinJ family
                     antitoxin"
                     /protein_id="WP_060986097.1"
                     /translation="MSTTADTYVRARIDTNTKERAASALEAMGLSISDAIRLLMLRIAD
                     EHRLPFDVKVPNATTKKAIAELEAGKGKKFASVDNLMADLHADD"
                     /name="type II toxin-antitoxin system RelB/DinJ family
                     antitoxin"
     gene            16000..16212
                     /locus_tag="C2U39_RS22715"
                     /old_locus_tag="C2U39_22720"
     CDS             16000..16212
                     /locus_tag="C2U39_RS22715"
                     /old_locus_tag="C2U39_22720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001373562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_041855125.1"
                     /translation="MKADRKDSRSSALERINLRLTPEVLKAIDAECSRRAGSVSRNTWI
                     TEAVTERLGRLASSSHPQGAGGANG"
                     /name="hypothetical protein"
     gene            16205..17353
                     /locus_tag="C2U39_RS22720"
                     /old_locus_tag="C2U39_22725"
     CDS             16205..17353
                     /locus_tag="C2U39_RS22720"
                     /old_locus_tag="C2U39_22725"
                     /EC_number="2.1.1.37"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005734775.1"
                     /GO_function="GO:0003886 - DNA
                     (cytosine-5-)-methyltransferase activity [Evidence IEA];
                     GO:0008168 - methyltransferase activity [Evidence IEA];
                     GO:1904047 - S-adenosyl-L-methionine binding [Evidence
                     IEA]"
                     /GO_process="GO:0006304 - DNA modification [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA cytosine methyltransferase"
                     /protein_id="WP_099533773.1"
                     /translation="MANFYEFFAGGGMARAGLGPDWQCLLANDFDPKKAASYAANWGTD
                     HLRVGDVAALTTADLPAGADLAWASFPCQDLSLAGAGAGLKGDRSGTFWPFWQLIKALG
                     DEDRAPRLVVLENVCGALSSHDGKDFAAISSALSNNGYRFGAVVINAVHFLPQSRPRLF
                     IIGVRKSSPIPRALVASGPEGEWHPSALVEAYGKLSKRAQSSWEWWRLPAPPARTSIFA
                     DLVEDKPHGVTWHTAAETKKLLGMMNPLNLAKVEAAKKAGGRQVGTIYKRTRADGPHGE
                     KVQRAEIRFDDVAGCLRTPTGGSSRQTIMVIEGKRVRSRLLSPREAARLMGLPDTYALP
                     KNYNDAYHLAGDGVAVPVVRFLAAHILEPLLAAALAVEKKAA"
                     /name="DNA cytosine methyltransferase"
     gene            17353..18282
                     /locus_tag="C2U39_RS22725"
                     /old_locus_tag="C2U39_22730"
     CDS             17353..18282
                     /locus_tag="C2U39_RS22725"
                     /old_locus_tag="C2U39_22730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003159130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4928 family protein"
                     /protein_id="WP_099533775.1"
                     /translation="MTDLVTALRDFNKDRKFNRKGPLCVALVVTQHARKGLPLNPDELL
                     TEAGGQVLGLGRGAVQAVLNRHDITRVLAAEGGRTSRGSISNMREYVAFLNGLAAAGAV
                     DLDAVEAFWIERVHEFFSAKPFKIRLDASRSLRTLVRDMIAQAEERQRNTPGMQYAGAV
                     LQHLVGAKLDCALGAGQFDHNSFSTSDAQSGRNGDFFIGDVAIHVTTAPGEAVIGRCRD
                     NIDDGHRPIIVTTARGLTVAEGLAENAGLGERIDVFEVEQFVALNLYELGKFAAEGRRV
                     AVGEVVTRYNEIVEEVETDPSLKIEFRQ"
                     /name="DUF4928 family protein"
     gene            18279..18455
                     /locus_tag="C2U39_RS24525"
     CDS             18279..18455
                     /locus_tag="C2U39_RS24525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003159128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_188073945.1"
                     /translation="MSNKAATISAAVPADVKAEAAAVAEAHGMSLAALVRELVARVAAR
                     ETETLAWLDEARR"
                     /name="hypothetical protein"
     gene            18452..18664
                     /locus_tag="C2U39_RS22730"
                     /old_locus_tag="C2U39_22735"
     CDS             18452..18664
                     /locus_tag="C2U39_RS22730"
                     /old_locus_tag="C2U39_22735"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_099533777.1"
                     /translation="MSRPRYTLDELLAEAEASGAYPLPAEEREWVDAPAVGREWPACET
                     LEGEGLANIARNDDDGRAGGSHRQE"
                     /name="hypothetical protein"
     Typing          complement(10894..11777)
                     /name="rep_cluster_995"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="80.856"
                     /coverage="88.0"
                     /evalue="0.0"
     Typing          complement(2003..5283)
                     /name="MOBQ"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="96.435"
                     /coverage="98.0"
                     /evalue="0.0"
     Typing          6006..8527
                     /name="MPF_T"
                     /typing="mate-pair-formation"
                     /tool="MOB-suite"
                     /identity="98.216"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 ctgtccattg tgttctgcgc ccggctcgcc gtgacctggt aggcgtcata agccgcctgg
       61 acgggggcca tgatcgagaa gcgggccgcg tcggcatcct ggccggcgtg cgcggtcgaa
      121 gccatcagaa gggcggccac ggccgccaga gggaaggaat tgcgaagttt catagctgtt
      181 gctccaaagg ttggggttca tcggaacgcc ggcggcgtcc ggtatcgacc tgggcgcaag
      241 cgcccggcct tcgagtttct ggaaggcttt taccggctgc gctcgatcag ctccgttgcc
      301 acggccagcg ccgtgccgat cggcacggcc tgggtaaagg cggcatcgga atggctgacc
      361 acgccgaccg cttcacctct cgcactgacg acaagcccgc ccgagttgcc gccagtcacg
      421 ggcgcgtcga tctgcaaggc ttcatcagcg gaaaaccggg cgctttctgc ataccggctc
      481 acaatgcccg cgctcacact gaacccacgg ccgccaggtg cgccgatggt caataccggc
      541 tggccctgaa tcggcatggc tcccgtcttg atcggctggc cgggttcgct gacgcgcaac
      601 acgcccacgt cgcgccgtag gtcaaggccg atcagctcgg catccagcca gcgcccggcg
      661 gccgtctgca cgcgatagcc gctcttgccg tcgatgacgt gggcggcggt gaggacatag
      721 cggccatctg cgataaacgc gccgctgccg atggtctgcc agtggcgcgg ctcctggtcg
      781 cggcttttca gccagaagcg gacagcgcca agggtggccg tcgccgggtt ggattgaacg
      841 ccaggaacaa gccagacgcg gctttcattg tccggcctgg tgacaaaggg cagggcggcc
      901 acattcacgg cggacgggat gacctgggga atgatgcgcg gccagtcggc ggcatccggc
      961 acgccgtcgc cctggcctcg caaggcggcg gcggtgatgc cttccgcaat gctccggctc
     1021 cgggctgaat aggcgtcgtt gtcgtgctcg gcgaagcgat aaagggcgtt cgcgttcgcc
     1081 tcggtcgtgg cgacggtata gcccgccacg gtcaaggatg cgcccgccag gatgtaggcc
     1141 gccagggcgg cacgtcgcca ggtctgcgcc ttcatcgtgc gccctcctta ccatcggccg
     1201 gcggctggat ggtgccgtcc atgatggcat cgcgcacggc gacatcaccg gaattgagcc
     1261 aaccggcgtg cgtccggtag gcgtgccaga acatgccgcc ggtgccgatc aggacggcca
     1321 gcgaaagggc aaaggtaatc cgatatttcg ttaggtcgcg gcgggtgccg ccggtaacat
     1381 tgcaagtagc catgatttca cctctatgtc aggtgggttg tggtcaggtg tccaggcggg
     1441 ttgccgcctt cctgggcacc gctttttagc ggctgaaact gcgggactgc tcccggtcgc
     1501 gtgccgcctt ttccttgaac cgttcggcga tttcccgcgc cctggcttgc ttcacctggt
     1561 cgccgttctc gttgtcccgg ttcaattcct ttgccagcgt ctttgcctgc tggccgttga
     1621 tctcgttgcg gtcgttgcgc tgctcggcgc tgtcctggtt ctgcgcgtcc agctcgaagc
     1681 cctgggcctg cttggcctgc ggctgctcgg cctcgatgtt ctgcgacgcc agcgcggccg
     1741 cctggccgtg ccgctctagc cgctcctggt ctttcgcctc gcggcgctcc tgggcctgct
     1801 cgatcttcgt tgcatagctc ttggcaagtt cttcgttcgt cggttcggtg ctcatcgtct
     1861 ttcctcctgg cgtaaaaccc ctattgctcg tttaaggata ctacaaaaac cgtcaaaaca
     1921 agttctttta atatccaaat aaatcattta ccggctataa ccgtcgcgct gcctggactg
     1981 ctcgcggtca cgctgcgccg ccctggggtc gcgggcgtaa cgctcggcaa gctcgttctg
     2041 catcttgtcc agctcgaccg cccggcgctg ttctggcatg gcgttgaacc gctcgatgcg
     2101 ctcgcgcagc tcgccgggca atgcctgcca cttcgacggg ctgcggtcgg tgaaaccggc
     2161 aatgttgttg cggcggccag cggccagcgt cttaaaccgg ctgacttcct ggcgtgcctg
     2221 cccctcggca accttgcggg cctgttcgct gacctggacg ggtgccgggc gctccggctc
     2281 ggccttggcc tggccctgct gcgccaggcc cgcaaaggcc cgctgctggc cttcctgcat
     2341 gatcgccgcc gaatggtgcc gggggtcttt cccggccgcc tggaactcct gggcgacggc
     2401 aagctgtgcg cgtgccacgt ccagcgccag gccaccgcct gcggcttcgg cccgctcgat
     2461 gccggcgcgg aatccggcca gcgggtcggg tgccgggcgc tccgcctggg gccgctgctg
     2521 cggcgctgcc acctcgccgc gttcctggct gacctgctgc cggaacttcg ccgcgatttc
     2581 ggccgcccgg cgcttcttct cgtcctctgg cgtgcgctcg atctgctccg gccgctgcat
     2641 ggtcggcttg cctgcaatgt cggtcgcggg catgaggtcg gggcggccgt ggcgttccag
     2701 attgcggcgc agggcatcgc gcatcttccc ggccagtgcc gacaccttgg cgcggccacg
     2761 ttccagccag cggcgcacca cgctttcacc gtcgaagccg cgccggtcgg caaagtccag
     2821 cgtgctttct ttcgggcgct cacggcccag cacctgggcc agcttcccgg cggccagctc
     2881 ggccgcgccg cgaacgtgcc aggtgttgcg ctcggcggtc gtgccgtccg gcaggcgcac
     2941 ggtttcagag ccgccatgct ccaagccgat acggtcgccg cgcttcgcgc cgctggatgc
     3001 aatggcgcgt tcaagatcga cgccccaaat ggtgtgccgc tcgcccttgt cgttctccaa
     3061 ggtggcaaag tagctggccc ggttctccgg cttgttctcg tagggcgctg cgccatgatc
     3121 gaccaggcgg ccggcgcggc ggtcggtgaa gtcgtcggct cctgcaaaca gggtcgccgc
     3181 ctcgcggtgc cgggtcatgc cgacataggc aaggctccta tccatgccgg gggtcgccag
     3241 caggtaagcc ctatcgacgg tgacgccctg ggccttgtga atcgtgacgg cgtaaccgtg
     3301 atcgacggcg gcatattggg acgcctgcac ctgccgcgct tcgccgctgt ccagacgcac
     3361 ggccaggctt ccatcttcgg cacgctcgac ggtgccaagg gtgccgttct tcacgcctag
     3421 atcacggtca tttttcagga acacaatgcg gtcgcctggg gcaaattccc tgcctccacg
     3481 ctcggccata aagcgggccg tgccgcgcag ctcgccgcgt tccttgcggg cctcgcgcac
     3541 ggcttcattg agcgcctgaa cgtccttatt gctgtgggca aggatgatct ggctaccctt
     3601 gccctgatcg ccgacatagg cggccgccag gccgtcgcgt gcagcgtccc ggctgtcgtg
     3661 aatctggacg tgtccgcgct cggcgtaggc cgccaggcca tcggccacgg aaccacgggc
     3721 aaactgctgg cccgcctccc gcgcccatgc ctctttctgg cgtctaacct cggtgatttc
     3781 tgccgcgcca acatgctgca caacgccccg gaaagccgcg cccgcctcga tggcggcaag
     3841 ctgcttatcg tcgccaagca agaccacttt tgccccggcc tgctcggcgg atttcagaac
     3901 gcggccaagc tggcgactgc cgatcatccc cgcttcgtcg atcaccagaa cgtcgcggct
     3961 ggtgagtttg tcttttccgt tcttccaagc aaattcaagg ctggcaagcg tccggctgtc
     4021 gatgccgctg cccgcctgca attcgtcggc ggctttgccc gccaaggctg cgccgcgcac
     4081 gttcaagccc tgcgcctgcc acgcctcgcg ggctaccttc atgctgaaag atttacccgt
     4141 tccagcatcg ccgatgacta cggccaggct gcccggtttg aggacgtgcc ggacggcgtt
     4201 ttgctgctcg gtcgataggg tgccagcgcc atcaatggcg gcgttcgtga tcgggctaga
     4261 aacaccatgc cgccctgcct gtgccagacg ctcggcgctg tccaccatgc cgcgctcggt
     4321 gtcgatcatt tcgcgggtgg agaacttcgc cggctcgcgc ccactggccg gttccatctc
     4381 gaccagaagc ggcgaatttt ccagcctggt aagcaagccc tggaactggt cggcgtcgtc
     4441 aatgtagcgg ttcagctcgg cggcaatatc gcggcgtgtg aaaacggcct gcgttgccgt
     4501 gatcttgtct aggatgatct ccgggcgctc ggtgatttgc tgcgcctgtt cctgccggtc
     4561 ggcgttgtga atgtcgatgc ggtcggcgtc cagtccgcgc ctatccatcg ccacggcatc
     4621 gcggcctatg tgcttggtcg gcgtgagttc cacgccttga tctgcatagc tccgatgatc
     4681 tacgcgggcg ctgatttcgg cacgctctag cgcctcgttt gtcagctcgg cccattgcct
     4741 gcgaatatcg gtaatgtcgc cctggcttgt gccgggaatg cccgccttct gcctgtcctt
     4801 gtttgccagc tcaatgacgg cctttgcgcc tagcgttcca tcctcgccaa tggtgcgcgt
     4861 agtcgccagc atatgaacgt gaaaattccg gtcgtcgccg tccttgtcgg gcgcgtgaat
     4921 gcaaacatcc acggccacgc cgtagcggtc ggcgatggcc tgccccatgc gcgttgccag
     4981 ctctttacgg tcggcgtcgt tcagctcatg cggcagggcc gcccgccact cgcgggccac
     5041 tcgcgcatct ttgcgcttct ctgcggcctc ggcggcattc cacaaggcgg cacgctcggg
     5101 aactggcacg ccttcgggcg tgacgatctc cgacgaaaga acgccgccct tccgggtgaa
     5161 gtcgaacgct tccccggtgc gctcatctac cagcgacgac gcggaacgat aggcggcagc
     5221 ggccacggcg ctatgcccgg ctgcccgtcc tatcgtgtgc gtgtttaggt ggtagatcgc
     5281 cattttttcc cttggcgttt tagccgctaa aaggggtgca ggggtatccc ctgccggaca
     5341 agggttgcgc agcaacccgt aagtgcgcat ttcgcttccg ctccatgact ataccagcgc
     5401 cgtgccttcc ccgccagcct cgccggtggt aagatcgtgt gcgcataacc cacaatctcg
     5461 aaaggagctg taacgatggc acgcaaaacc ctatccgaac gcaaggccga caagctggcc
     5521 gaactgaacc gcatcaagtc agaactggcc gatctggaaa acaaggcagc cgagaaaatc
     5581 ggcaagattg ccattgccgc cggtcttggt gatctcgaaa tagatgatgc tcaactgcgg
     5641 aaggagtttg aggctatcgc ctcaaaattt cgcaaaagcg aaggcaagca agctgcttcg
     5701 gtggcggcaa cgcctagcgc agattgaacg caacttagga cgcttgcgga tgaacgccag
     5761 gagagaagat gcacgccgga aaatccagct aggcggcttg gtcatcaagt ccggtatggc
     5821 ggactatccg gcatccgtga tcttgggcgc tttaacccta gcggctggtg cgctcaaagg
     5881 gccgaacgct gacgccacaa aggcgcgttt tgaagcggct ggcgatgagg ctttttccga
     5941 tgatggagag gacggcggca accgttccta gccgtcaatt tgtgacctga catagaggtg
     6001 aaacatgatg gacgtgaaag atttactttc gagaatgtgg gccgccgtgg tggcggtgtt
     6061 tttcggggtg ttcgtgttgt cgttggcaaa cacggcgcac gctcgcgttt tccccgaatg
     6121 caacccggca gcagaggccg cgaagttcta cggcgcggaa gatgtagatg cctgggtgaa
     6181 gcgcgtttgt gacgcgcagg aaacggcttt ccagacttgg gaaacaaacc tgcaaaagct
     6241 cgacattggg cagcaagatt tgtcgatggc gacgaacgcc gggaattggc aagcctaccg
     6301 ggacaagtgg gccgaattgc tgccggtgtt gaaggaactg gaagccgctg cggtggcgaa
     6361 ccggaacgca ccaggcgcgg caaatatcct gagcctgtat cgcaacgatt tgggcctttt
     6421 cttacagaat tcgggccttg cctcggcggg tagcctggac gatttcagcg cccggattct
     6481 ggcgggcctg gacggcgaac ggccagcggc ggcggctacg gctggcgtca atgtggttca
     6541 gcagtcggtg acgcggggca ttgagttcgg caagggcgtt ggcacggcag aagccgataa
     6601 ggtgctggcc gaatatcgcg gccaaatgga acagcgcacg gcggaacgca tggaacagct
     6661 cggcggctcg acaatgggcg gctatttcgg cggcttcggc acgcgcatca aggccgcttt
     6721 cggtggctgg ttgttctacc tggtaacggt ctgctttatc ggtgcctgga tggcgcacaa
     6781 gcgccgacaa aacccggtca cggtcggcac ggccgttggc ctggccttcc tcgttccatc
     6841 ggtcggcatg ttgcttctgc tcgtgttcgc gccgttcatt ccgggctggt tcatcctcgc
     6901 cgcgacggtc gccggaacgg tggcaacgta tctgaacgcg ggccgggtgt tcggctggct
     6961 ggctggcgtg gttggtgccg aatctccgac cgggaaacgg ctgcgcatcc ttggcgggac
     7021 aatcgaaaac ctgcgcggcc aggtgcagcc ctccgggccg gtcgcggccg ccggtgctgc
     7081 ggccgctgcg gtcgataaca gcagcacgca tccgcttggt tcgcacggct cggcacgatg
     7141 gggaacggtc gatgaaatcc gccagggcgg ccacctggtc gcgcccggca agccgggcgg
     7201 ttttgccctg ggccgcgtgc ctgacgcgct ggccggcatg gatgcccgtt tccgcttcgt
     7261 cggccatgtc gtgacggtcg cccctaccgg ctccggcaag ggcattggcg cggtgattcc
     7321 gaacctcttg gactatcccg gctcggccct ggtgctggac gtgaaaggcg aaaacgcggc
     7381 cgtgacggcc cgcgcccggc gggcgctcgg ccaggcggtc tattcggtcg atccgttcgc
     7441 ggtgaatggc gacggcggcg cggccttcaa cgtgcttgac cggctcgacg tgtggaaccc
     7501 ggattgtgtg agtgaatcgg ccatcctggc cgatgccctg gtgatcgctg agagcaaggg
     7561 cgatgccgtg catttcgatg aatcggcaaa gaacttcctg caaggcttga tgctgcacgt
     7621 tgccgggctg gatgacgcgg aacgccggaa cctgggcgaa ctgcggcggc tgctgacggc
     7681 gggggaatcg gagttcttcg acgtgttggg cgcaatggcg gccgacgata cggcggcctt
     7741 cggcatcccg gccagggcgg caaatacgct catgggcatg gctgacaaag agcgcggttc
     7801 ggtgctttcg acggcacgcc ggaacacggc atttctggat gacccacgca ttgcggccgc
     7861 gctgtcgcgc tctgacttcg atctgtcgga aatcaaggcc acggccatga cggtttatct
     7921 tgtcatgccc gccaatcgca tcgggcctaa tgcccgcttc ctgcgcctgt tcatcagctc
     7981 ggtaattgcg gccatcacgt ccagcaacgt gcagcccgcg caccgtgtcg ccttcctgct
     8041 cgatgagttc ggccagctcg gctacatgaa acagattgag gatgccgttt cactgctgcg
     8101 cggctacggc ctggccttct gggtgttcat tcaagacctg tcgcagctca aaggcaccta
     8161 tcccaagtgg caaaccttcc tggcgaacag cgcaaagtcg ttctttggca cggacgatta
     8221 cgacacggcc aaatacatca gcgacagcct gggcaaagcc acgattgagt ttgagacgga
     8281 aaacaccggc aagaacagcg gcagcggcct atcaggcggc ggcggctcga tgaaccgggg
     8341 caagagcacc ggcacaagcc agcaattcac cgggcgcgaa ctgctgacgc cggatgaagt
     8401 catgcgcctg gggccagagc atccgattgt cctggtgcgc ggggaacgcc cctacctgct
     8461 cgaccggctg aactacttgg ccgattccga atatgccggg cgcttcgatg cgaatcccta
     8521 ccatagctga gggatgacgt atggcgttca tcatcgcggc ggttctcggt gtcatcgccc
     8581 tggcgtggtt cctgcggcgg ctgttccctg ccctgttcgc ggcggtgttc gtcctgttcg
     8641 cgccggtgtg gctggtcggc ggtgcgctgc tcgatctgct gcgccggccg ctggccttcc
     8701 tgcggccggt cggcctcgcc ctggcccgcc tggtcggctt cgtcctggtg ctgccgctgc
     8761 tgcccttcat cttcgtctgg tcgttcttcg cggaactgtg gcgacagttc cggccgtcga
     8821 aggccagcgc cccggcaccg gccggggtca agccgcctac gccgatgcag gccgccacaa
     8881 agcgcacggc ggacgtgatc gacctggccg cctggcggcg gcacaacgat ggcaatgcag
     8941 agtgaagaaa gcggccttta atattcaaag gatatttttt agccgctaaa gcgcccctca
     9001 aatgtcaaca tcaaggccgg gaaacgcatc agcattcccg gccttttcgt tcggccatat
     9061 cttgacactt ggggggcact cactcgccgc cgggattctt cctggtcggc ttggcttcgg
     9121 ctggcgtgat acgcgccagc agcgcggcgg attgctcttt gagcgtgtcg atttgcccgg
     9181 ccatgcgtgc ggcttcctcg cgtgcctgcc cggcggcttt cgtggcctgg tcgcgttcgg
     9241 cctgggcggc ggtaaggcgt tcggcgatgc ggtgcgcttc ggctgctgcg gccttgcgtt
     9301 gttcctggtg cgcgtcctgg tcggcttcgg ccttggcctg caccttcgcc agctcgccgc
     9361 gcacctggtc gagttgggcg gcggcggcct ggctggtctg gtgcgccctg tccagctccg
     9421 tgcgcagctc accggcgcgg cgctcgatct cctgggcgcg tgcctcggcc gtgtgtgcct
     9481 gttcctgggc ggcggccaac tggccgcgca gctcggcggc ttcgccgcgt gcggccgctt
     9541 cggcggcctc gatggacgcc aggcgggatt gcagggcttc cagctcgccg gcctgacgct
     9601 cgaaagcctc ggccagctct tgccgcatgg cgtcttgctc tacccgctcg gtttcccatg
     9661 cggcctgtgc gctgcgcagg gattcgttcg ccagctcctg cgcctgttgc cagatcgccg
     9721 ctacggccgc gctgctggcc tgctgcacgg attccggcac ggccacggcc accggcgcgg
     9781 cctgggccgt ctgcgccctg cgccattcct tcatcacggc actggcggcg ttcatatcca
     9841 cgcgggcggc acggcgcacg gcatcgaccg tgggcatggt ctggcggccc gactgctcga
     9901 aaagatcggc ggcggcggca atgatgcgct cgcgcacgtc ggcggggatt tggggggctt
     9961 gctgcgtcat ggccttggct ccggtggata agataagaat aataatacta ttcttcttat
    10021 tattatgcaa gcggttattt tcgcccagtt cttggggtcg gcccggccgg gagcgcgtga
    10081 cggtcgaaaa tcggccctgt gtggcccgtg gcggcgtttt ctagggtcgg cggcacctat
    10141 cccctaccct cgccatcttt cgcgcctcct gcgcgtccct gtgcggcctg ggcgcattgc
    10201 ttggcggtcg tcatcgtcgg atgtggcgat gctggccagc tcgatagcct ggcggccctt
    10261 ctttcttggc gttcaacctt gcggccttcc agctcgcgca ggtgttcgag ttgagcgcag
    10321 gcggtcggcc tgcctgcttt tcactgctaa accgcttttg acggcctttc agcgggcgcg
    10381 gtgctggatg tgggcgcagg cggtggaact ggcaccggcg cggcgtgccg cgcctggtag
    10441 atgcctggcc gcaggccagc catttgatag gccgacgcga agcggcgggg cgaagggagc
    10501 gaagcgaccg gagggcaggc gcgcccgtag ggcgttgcgg tggttcggtt cgcgctgtcg
    10561 gtcggttttt tccacagatt tggcctgcca attacaggca agtatttata ggaaaaactt
    10621 aaaggcttaa ccgtaccggt ttaggggggg tctgatctaa cgaccctggg ggggtctgat
    10681 ctatcggaga aaacaggggg tgggggggtc tgatctatcg gggtgggggg gtctgatcta
    10741 acgtggataa gtgcggctat ccacaggatt tatccccaga ttggacgcca agagggggca
    10801 tcggccagaa acgacgcggc cgcctcgatc tcgggcggcc ggtgtgctgc gtgtgggggg
    10861 gtctgatcta tcggagttta gctaaacttc ccgccgctct taggggcaat gggcggcggg
    10921 gagccaagca acagcaggcc accagtgacg ggcttcacct tcgcttgcgg atagacggtc
    10981 agcaccttct tgagtgccgg cacaaacttc ttcttgaagt ccttgtctgc atccttcccg
    11041 gtgtattcct gggcgaactg ctcccgcagg gacttccagt gcagcgttac gcccctgccc
    11101 tcgatgcggt gcagtcggtg ggccagccag gtgtaaacgt ccagcgcaag cgcggaacct
    11161 ttcagggcca tcagggcgcg attgtccagc gggacggcgc tatccatcag cgagttgaaa
    11221 tagccctctg atagaaccat cgtgccgggc caaagtgatt tctgctgcgc gtcgccattc
    11281 gccagccagg catcgaactg ttcgacgggt tggccgttgt aggtgcgccc cttgaatcca
    11341 agttgcaggc ggcaagcggc cagggcgtgc atttgacggc gcaaggtggt gtaacgcgct
    11401 ccctggtcat ccatgcccat gagccgcaag aactcggccg cgctgtcacc gatggggatt
    11461 tcccgcgtgt tgtctcgctt ggcgtagctg gacacccagg caagcgccag gcgcggcatg
    11521 acgccatagg ggataggttg cagcaccggc ccctttcctt cgtccagata gccggcctgc
    11581 acattgaccc aggcagcgcc ggactggcgc atgaactcgc gcccttcgac ttttgagcgc
    11641 ggcaaaccga cctggcacag cacggcatgg gtgaaagcca tgtcctcgcc gctcggcggg
    11701 ttggtggcga tctctgcgcc ggcctcgatc agcttctggt cttgctcggt caggatgatg
    11761 ccggccgggg tgatcttggc cccggcgcgg ggcttcctgg tcttggcctc tgccttggcc
    11821 tgcgccttca cgatcaggcc gcccaaaatg tcgccgatct gttgcgcctc ctgtccatcc
    11881 cgcttcttgt tcatggtgcc tgcctttagc cgctaaaaat gtctttggat attaaatgaa
    11941 ccttcttgaa aggttgttta gctctggaaa atattgcctt ccaatgcgtt gaaaatcgcc
    12001 atgttgatga tcgcggcacg ggcctggccg gtgcgcttgg cgacttcatc gaccttacgc
    12061 agcagctcgg gcgatatggt caaggtgatc tgccgcttgt tgcccttggc aatgcccttc
    12121 tcatagacgg cggccggggt ggcctcggtc ttagcgtcgg gtgcgccctg gatgaaagca
    12181 tcttctgccg ctgcggggcc ggtcttgggt ttgcgctgga ttgccatttc taaagctcct
    12241 gttacgcgat tttttggata ttaaagagcg atgcaactag gctatcaagc tcggctattg
    12301 ctttcgggtc gcgtggggcc agctcggcca cggccaggcc agcgccgccg gcgttgctga
    12361 acgccttgcg gcggcggatg ggcgtcggca gatactcgaa ttgcggaacc tccgccacgg
    12421 cggcggccgc gtcggcgttg tcggccgaat gctcgccggg gtcggcctgg ttcatcacgg
    12481 catagcagcg caggccgtcg cgcacgctgc gggcctcatc gaccagcgcg gccatatcgt
    12541 ccagcgccca cacgtcatag gaacgcggcg cgaatggcac cagcagaaca tcggacaaga
    12601 ccagcgcggc ccgtagcgcg gtcgagtcgc ggccgccggc gtcaatgatg atgtcttgcc
    12661 acttgtcccg ctgttgttgc acttggccgc gcaaggccgg gccgtccgca tactgggcgc
    12721 acgcgatgcc gggctggcgg ccagcttcgg cccgtgccgc gatagcggcg gcggcggttc
    12781 cctgccggtc gccgtcgatc agccacacgt cacgcccggc cagggcgcgg gcaatggcga
    12841 tctgaaccgc aagggttgtc ttgcctacgc cgcccttggt gttgcctacg gtaataatca
    12901 catagcacct caaaaggata ttaacttaca gtgccacatt gtgccgccct gacgcgatgg
    12961 cgtcaatagg tttagggcat cttttgaagg ttcttttaat atccataaaa gcgcctttag
    13021 ccgctaaatt ttgcgccgcc gttcccgctc ctggtcggcc agctcgccgg gccagctcgc
    13081 cagctcgtca tcggggaggg cggccaggat ttgcggcagg ctctgcgttc gatacggcgg
    13141 cggcggcaga tcatcggccg ggccttcgtc atcaaggaat gccgggcctt cttcctggcg
    13201 ttcatcatcg acggccgcca gggcgtcggc ctcgctcaat gcgtcctcgg cgaacgcacc
    13261 acgtcggcgg gcctcggtct ttgtcacttc ctcgccacgc gccagcgccc ggtaaagggt
    13321 cgaacgatgc acggccagca gctcggccgc ttccttcacc gtccggccgt cacggtcgat
    13381 cagctcgcgg gcgtgctcga tctgcgccgg ggtgagggta gggcgcgggc cgaacttcac
    13441 gcctcgggcc ttggccgctt cccggccgtt cctggtgcgg tcgatgatta gggaacgctc
    13501 gaactcggcg atgccggcaa acacggtcag aaccatgcgc ccggccgggg tggtggtgtc
    13561 ggcccacggc tcggccaggc tgcgcaagcc cgcgccggcc gcctggatac gctcggcaat
    13621 gtccagcagg tcgcgggtgc tgcgggccaa gcggtcaagc ctggtcacgg tcacaacgtc
    13681 gccagggcgc aagtgatcga gcacgcgggc cagctcgggc ctgtcgcgcc tggtgccggt
    13741 gatcttctcg gcaaagatgc gcgtgcagcc tgcggcgtgc agctcggcgc gttggttggt
    13801 caagtcctgg tcgtcggtgc tgacgcgggc atatcccagc agtaggccag cggcggcgct
    13861 cttgtctttc atggcgtaat gtctccggtt ctagtcgcag gtattctatt tcatgcaact
    13921 aaaacacgcg acacaaaacg ccagggaaag ggcagggcgg ctgtcgtttt cagaagccga
    13981 ctgcacggaa tatcaggagt cggctgcact acttcttacg ggcacgttcc atgtgcagaa
    14041 cggcgtcaag caatgccatt gaatcgcagg cgtcagaggc gtagaccgtg cgagtccctg
    14101 agtcatagga caccatcacg aattggtcgg gtgtgcgctc tgtactccgg ggagcttgcc
    14161 gcttggagcg gtaggctcta cacacctctc tcttttcggc aagctgctgg ccgatcttct
    14221 tccagtcaaa gaggtggtcg ggatacaacc ggcgcatgtc gcgcttgtcc tgcggcgtaa
    14281 tcgtgtagct gcgaatacgc atgatgttga aattgcttct gccgactttg accgtcagat
    14341 agcaaaagcc ctttctggtc gtgacgaacg cgctgctttg cttgcggctc atcgttgctc
    14401 gcttccgcct tgcagcgcgg tgtacagggc cgtcttgctc accttgagcc gcgtagcagc
    14461 ttcccggacg ttcagcccat tggcgatatg ctcccgcgcc cgctgcaact tgtcggcggt
    14521 gacaaccggc ctgcgtccgc ccttgcgccc gcgtgcggcg gcagcagtca atccggcttt
    14581 ggtgcgctcg cggatcaggt cgcgctcgaa ctggcccagg gcaccgaaca catggaagat
    14641 gagccgtccg cccggcgtcg tggtgtctat gttttcggtc agcgaccgaa agccgacgcc
    14701 ccgcgcttcc aacttgccga ccgtctcaat caggtgtggc aaggagcggc ctagccgatc
    14761 cagccgccag acgaccagca catcgccatc gcgcagatag gccagcgcat cggccaagcc
    14821 gggacggtcg gccttggccc cggaagccgt gtcctcgaac acccgttcgc agcccgcctt
    14881 gtgcagcgcg tcggtctgca aggcagtgtc ctgttccgct gtcgataccc gcgcatagcc
    14941 gatgagtgcc attgccgccc ttttgtccgc cattccgtcc gtctatctta ttgtccgtca
    15001 tcccgttgcg caaggtgttt tcggacaggc gtccggcttg accgtctaat gatcgtttta
    15061 cggacagggc ggcgcattgg aacagcgaac cgacttaagc cggaacccca gatttttccg
    15121 gccagtggct aacggtcgtg tcgccgccac catctgacgg ctggcgtcag ccgaaaagct
    15181 cgctatgcga gccaagccgc gccagtcgca gagtgtcgga atcggacttg cggtaaatca
    15241 gcagcaggtc gggcttgatg tggcactcgc ggtagcccgc ccaatcgccg gaaagatcat
    15301 ggtcgcggtg gcgcgcgtcc aacggctgat cggtcgccag cgcgagcagc accggcttga
    15361 gcgcgtcatc gagcgtggca cggtgctgtc ccttggcctc gcgcttgaaa tcgcgcttga
    15421 acgcggacga acgatcaatc gtccgcatgc aggtctgcca ttaggttgtc cacgctggcg
    15481 aacttcttgc ccttgcccgc ttccagttcg gcaatcgcct ttttggtcgt ggcgttgggc
    15541 accttcacgt caaaaggcaa gcggtgctca tcggcgatgc gcagcatcaa caggcggatg
    15601 gcgtcggaaa tcgacaagcc cattgcttcg agtgcgctgg cggcgcgttc cttggtgttg
    15661 gtgtcgatgc gggcgcggac gtaggtgtcg gctgtagtgc tcatggcaat tctccgggaa
    15721 tggttcaaac acccatattg tagtcacaat gcgaccacat aacaaggccg catcgtgcag
    15781 gggagttctg agcaattccg gttcttcgcg gcgcttcgtg tataggactg ctgacgcggc
    15841 ccgttcagaa gtcggctgca caccgggcgg ccagccccgt gaactggtgc agtcgtcttc
    15901 tgaaaatgac agcggcaagc tgtcgcacaa cttaggactt atgcgacgtt tacaataaat
    15961 tccttggcct tgagccacga tggcgccaca atggcgccca tgaaagccga ccgcaaagat
    16021 tcgcgctcta gtgcgctgga acgtatcaat ctgcgcctca ctcccgaggt gctgaaagcc
    16081 attgatgccg aatgctcgcg ccgggccggc agcgtatcgc gcaacacttg gattaccgaa
    16141 gccgtgacgg aacgcctggg gcgtctcgct tcgtcatcgc acccgcaagg tgcaggggga
    16201 gccaatggct aatttttatg aatttttcgc cggtggcggc atggcccgcg ctggccttgg
    16261 ccccgactgg caatgcctgc tcgccaatga cttcgaccca aagaaggcgg ccagctacgc
    16321 cgcgaattgg ggcaccgatc atctgcgcgt cggcgacgtg gccgcactga ctacggccga
    16381 cctaccggcc ggcgctgacc tggcttgggc ctcgttccct tgccaagacc tttccctagc
    16441 cggtgccggt gctggcctca aaggcgaccg ctccggcact ttctggccgt tctggcagct
    16501 catcaaagcc ctgggggatg aagatcgagc gccgcgcctg gtggtgctgg aaaacgtatg
    16561 cggcgccctt agctcgcacg atggcaaaga ctttgccgcg atcagctcgg ccctgtcgaa
    16621 caacggctat cggttcggtg ccgtggtcat taacgccgtt catttcctgc cgcagtcgcg
    16681 gccacggctg ttcatcatcg gcgtgcgcaa atcctcgcca attcctcgcg ccctggtcgc
    16741 cagcggcccg gaaggggaat ggcatccgtc cgcgctggtc gaggcttacg gcaagctctc
    16801 gaagcgtgcg caaagctctt gggaatggtg gcgcctgccg gcgcctccgg cccgcacgtc
    16861 gatctttgcc gacctggtgg aagataagcc gcacggcgtc acctggcaca cggccgccga
    16921 aacaaagaag ctgctcggca tgatgaaccc gctaaacctg gcgaaagttg aagccgccaa
    16981 gaaagccggt ggccgccagg tcggcacgat ctacaagcgc acccgcgccg atggcccgca
    17041 cggcgagaag gtgcaacgcg ccgaaatccg tttcgatgac gtggccggtt gcctgcgcac
    17101 gcctaccggc ggttcaagcc gtcaaaccat catggtgatt gagggcaagc gcgttcgttc
    17161 gcgtctgctg tcgccgcgtg aagcggcccg cctcatgggc ttgccggaca cctacgcgct
    17221 gcccaagaat tacaacgatg cttatcacct ggccggcgat ggcgtggccg tgccggtcgt
    17281 gcgcttcctg gccgcacata tcctagaacc gctgttagcg gcggccctgg cggtcgagaa
    17341 gaaggcggcg taatgacgga cttagtaacg gccctgcggg acttcaacaa agatcggaaa
    17401 ttcaaccgca aaggcccgct gtgcgttgcg ctggtcgtca cgcagcacgc ccgaaagggg
    17461 ctgccgctca accctgacga gctgctgacc gaagccggcg gccaggttct cggcctgggc
    17521 cgtggcgctg tgcaagcggt tctgaaccgc cacgacatta cccgcgtttt agccgctgaa
    17581 ggcggccgca ccagtcgcgg cagcatcagc aacatgcgcg aatatgtggc cttcctcaac
    17641 ggcctggccg ccgccggtgc ggtcgatctc gatgccgttg aagcgttctg gattgagcgc
    17701 gtgcatgagt tcttttcggc caagccgttc aagattcgcc tggatgcctc gcgcagcctg
    17761 cgaacgctgg tgcgcgacat gatcgcccaa gccgaagaac ggcaacgcaa cacgccgggg
    17821 atgcagtatg ccggcgcggt gctgcaacac ctggtagggg ccaagctcga ttgcgccctg
    17881 ggtgccggcc agttcgatca caacagcttt tcaacgtctg acgctcaatc gggccgcaat
    17941 ggcgatttct tcattggtga tgtggctatc catgtcacca cggcgcccgg cgaagcggtc
    18001 attggacgtt gccgcgacaa catcgacgac ggccaccggc cgatcatcgt tacgacggcg
    18061 cggggtctga cggtcgccga agggctggcc gaaaatgccg gcctgggcga acgcatcgac
    18121 gttttcgagg ttgaacagtt cgtagccctg aacctctacg agctgggcaa gttcgctgcc
    18181 gaaggccggc gcgtggctgt gggtgaagtg gtgacgcgct ataacgagat tgtggaagaa
    18241 gtcgaaaccg acccaagcct gaaaatcgaa tttcgccaat gagcaataaa gccgccacca
    18301 tcagcgccgc cgttcctgcg gacgtgaaag ccgaagcggc cgccgtcgcg gaagcgcacg
    18361 gcatgagcct ggccgccctg gtgcgcgagc tggtggcccg cgtggccgcc cgcgaaactg
    18421 aaacgctggc ctggctcgat gaggcccgcc gatgagccgc ccgcgctaca cgctcgatga
    18481 gctgctggcc gaagccgaag cgtctggcgc gtacccgctg ccagcagaag aacgggaatg
    18541 ggtcgatgcg cccgccgttg gccgcgagtg gccggcctgt gaaacgctgg aaggcgaggg
    18601 gctggccaac atcgccagga atgacgatga cggccgcgcc ggtggatctc atcgccagga
    18661 atgacgatgc aagatccaga cgtgaaaagg gcggccagtg gccgcccttc ttgttcctgg
    18721 tcgccgttac cggctcgcgt tccagtctgc catcttcaac tgtgccaggg ctgattcagc
    18781 gtgcagcctc tccaatgcgg ccgcctcgcg ggcgcgaagg gtggcaagcg ataccgccag
    18841 cagctcgcgc cgctcggccg acaagccggg ttcgcgtagc tcggcctcga tg
//
