LOCUS       NZ_CP018445             9294 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Klebsiella pneumoniae strain Kp_Goe_822917 plasmid pKp_Goe_917-4,
            complete sequence.
ACCESSION   NZ_CP018445
VERSION     NZ_CP018445.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN05412453
            Assembly: GCF_001902415.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Bohne,W., Bunk,B., Overmann,J., Gross,U. and Zautner,A.E.
  TITLE     A nosocomial outbreak of oxa48-expressing Klebsialla pneumoniae in
            Lower Saxony
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9294)
  AUTHORS   Bohne,W., Bunk,B., Overmann,J., Gross,U. and Zautner,A.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-DEC-2016) Department for Medical Microbiology,
            University Medical Center Goettingen, Kreuzbergring 57, Goettingen,
            Niedersachsen 37075, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: SMRT Analysis Software v. 2.3.0
            Genome Coverage                   :: 117.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/04/2024 14:52:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,540
            CDSs (total)                      :: 5,416
            Genes (coding)                    :: 5,303
            CDSs (with protein)               :: 5,303
            Genes (RNA)                       :: 124
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 12
            Pseudo Genes (total)              :: 113
            CDSs (without protein)            :: 113
            Pseudo Genes (ambiguous residues) :: 0 of 113
            Pseudo Genes (frameshifted)       :: 44 of 113
            Pseudo Genes (incomplete)         :: 69 of 113
            Pseudo Genes (internal stop)      :: 15 of 113
            Pseudo Genes (multiple problems)  :: 15 of 113
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP018445.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="Kp_Goe_822917"
                     /isolation_source="skin swab"
                     /host="Homo sapiens"
                     /culture_collection="DSM:103702"
                     /db_xref="taxon:573"
                     /plasmid="pKp_Goe_917-4"
                     /geo_loc_name="Germany: Goettingen"
                     /lat_lon="51.53919016 N 9.91156249 E"
                     /collection_date="2013-03-12"
                     /collected_by="Andreas Erich Zautner"
                     /genotype="MLST ST11"
     gene            join(9137..9294,1..220)
                     /locus_tag="BB746_RS29500"
                     /old_locus_tag="BB746_29305"
     CDS             join(9137..9294,1..220)
                     /locus_tag="BB746_RS29500"
                     /old_locus_tag="BB746_29305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            complement(282..581)
                     /locus_tag="BB746_RS29505"
                     /old_locus_tag="BB746_29310"
     CDS             complement(282..581)
                     /locus_tag="BB746_RS29505"
                     /old_locus_tag="BB746_29310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001146176.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(571..834)
                     /locus_tag="BB746_RS29510"
                     /old_locus_tag="BB746_29315"
     CDS             complement(571..834)
                     /locus_tag="BB746_RS29510"
                     /old_locus_tag="BB746_29315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     gene            complement(1140..1559)
                     /locus_tag="BB746_RS29515"
                     /old_locus_tag="BB746_29320"
     CDS             complement(1140..1559)
                     /locus_tag="BB746_RS29515"
                     /old_locus_tag="BB746_29320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="WP_001254601.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="Exc2 family lipoprotein"
     gene            1962..3647
                     /locus_tag="BB746_RS29525"
                     /old_locus_tag="BB746_29330"
     CDS             1962..3647
                     /locus_tag="BB746_RS29525"
                     /old_locus_tag="BB746_29330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_004178188.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            3657..3914
                     /locus_tag="BB746_RS29530"
                     /old_locus_tag="BB746_29335"
     CDS             3657..3914
                     /locus_tag="BB746_RS29530"
                     /old_locus_tag="BB746_29335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            3999..4148
                     /locus_tag="BB746_RS29535"
                     /old_locus_tag="BB746_29340"
     CDS             3999..4148
                     /locus_tag="BB746_RS29535"
                     /old_locus_tag="BB746_29340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            5629..7593
                     /locus_tag="BB746_RS29545"
                     /old_locus_tag="BB746_29350"
     CDS             5629..7593
                     /locus_tag="BB746_RS29545"
                     /old_locus_tag="BB746_29350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_004178196.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            7593..8324
                     /locus_tag="BB746_RS29550"
                     /old_locus_tag="BB746_29355"
     CDS             7593..8324
                     /locus_tag="BB746_RS29550"
                     /old_locus_tag="BB746_29355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     gene            8331..8861
                     /locus_tag="BB746_RS29555"
                     /old_locus_tag="BB746_29360"
     CDS             8331..8861
                     /locus_tag="BB746_RS29555"
                     /old_locus_tag="BB746_29360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(8889..9068)
                     /locus_tag="BB746_RS29560"
                     /old_locus_tag="BB746_29365"
     CDS             complement(8889..9068)
                     /locus_tag="BB746_RS29560"
                     /old_locus_tag="BB746_29365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     BGC             1..8647
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(4252..4830)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          7594..8321
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 aagacaggat gagactcacg agcgggacga gttgagactg tcgggtgaga ctgaaaaaat
       61 ggcctccgac gcgttgatcg cggagataaa agcactcagg gaggaggtgg ccgggctacg
      121 gcaggaaatg cagtccatga gactgctgga acacaaaccg gagacagcag agaccccggc
      181 cggaacaccg cgccggtggt ggccgtgggg aaaacgctga cgcgctgtgc ttgtccaacc
      241 ggcgacggcc acgcaatgaa ttgcgtcccc gtcaccggtt attagagaac aatatgggga
      301 ttctggcgct ggccgaccac ggccagaacc cggacttttc tggtctggtc atcaacatca
      361 tagaggacat gctgtcccat cagactgatc cggcgaacgt cctcgccata gcgtgagtcc
      421 acttcataga gtcgcgggaa gtcggccagt ttgtccgccg cagcgagaac ccggtcggta
      481 acgttctgcg catcccacag ggatgaattt tccgcgatat agtcaaacag cgtcgttaca
      541 tcctcgatgg ctccctgctt ccattccacg tcatacggca tcgcgcagtt cctgataacg
      601 gccatgcagg cgctggcgga gttgttccgt ggtcataccc ggacgcgtgt cagcacgggc
      661 ggcggtcact ttggcgcgaa cctgatcttc atactctgcc tgggccagtt cttcgttagc
      721 cagtcgctgc aacagcgcag ctttgtccgg gccaccttcc ggcagtatgc ggggcaggct
      781 ttcagccagt tcccgaagaa agttggcgtt ttcgtagtgt gtagtgttgc tcattgcgga
      841 gcctcccggg ttaatgcggc aatatgaagg aagtttagca gggggcggtc tgaaagaata
      901 tggtcgtgtc agtcaggctg atgaagcaga aagtcggtaa aaaagggctt acggcatcca
      961 ttttacgtca aaacatatgc catgcagttg cgtgcatagg catgcattag gataaaattt
     1021 atcgggcgcg tttccggcag ttttccgggg gggttgttgc ctgttttatc ccgtagccgc
     1081 cggaaacgcc ctgagcccgt ctgagcggtg cgcgtaatga cgcgttatgg taaatccact
     1141 tactgtctgc cttcatagcc atcgagataa acagctgaaa tggtgtcagc cagtagcctt
     1201 gattttttcg gtgtgaggtc tttgctgcgg taatcggtac ccgcaaattg tgttgtgcct
     1261 tggagtgagt ttaaaaattc ctgactgtga aactgctgaa tgcgttgctg cacatcactc
     1321 cgtgattttc cggtcgcttt atcctttgcg cccatatccc agaactgccg gaaaaaaggc
     1381 accatcattc gtgttgtgtc agctttctgg gtggaaaaat tgggatcaaa accgtcatct
     1441 gaagcatata cgtaatgccg ggtatgctgt tccacgctgc cctttggagc acaggcagtg
     1501 agagttgctg tcgctgttat catggcgata agacacagtt tgctgccgga acgtctcatg
     1561 agcgtctcct tacctttaat tcttttttct cattgagtta tatatccgca ggctatctta
     1621 tcatcagttt ctgaccgtgt tcagtgaccg aacaacccga accagacccc ccgtttcttt
     1681 tcctgtcccg gagggggctt tctggtatct catataatga tttcagtaaa acatactgag
     1741 gccggagaac ggcgccgttt gtgctggttt ttgttgcatc tggaggggat tgcgcatggt
     1801 gtgagtggct gtttttttga tcattttcac aaaaacgcaa atttacagac ttgacatgaa
     1861 aaacaaggca gcgtaatttt tatactgtat ataaaaccag tggttatatg tacagtattt
     1921 tattttagtt tattgtttta aaagtcaaag aggaaaagta tatgagtggc ggagacggac
     1981 gaggtccggg taattcaggt ctgggacaca atggtggtca ggccagtggg aatgtgaacg
     2041 gtacatcagg taaaggtggc ccttcatcag gtggtggtac ggatccaaac agcgggccgg
     2101 gctggggtac gacgcataca cctaacgggg atattcataa ctataacccg ggggagtttg
     2161 gtaacggcgg gagtaaaccc ggtggtaatg gcggtaacag cggcaatcat agcgggagct
     2221 ctggtggcgg acagtcttcg gccaccgcga tggccttcgg tctgcctgcc ttggccactc
     2281 cgggggctga aggactggct ttatccgttt ccggcgatgc gttgtcggcc gctgttgctg
     2341 atgtgctggc tgccctgaaa ggtccgttta agtttggtct gtgggggatt gcgatttacg
     2401 gagtgctgcc ttctgagata gcaaaagatg atccgaaaat gatgtcaaaa atcgtgacgt
     2461 cattgccggc agacacggta acggagacgc cggtcagctc cctgccgctg gaccaggcga
     2521 cggtcagcgt cactaaacgt gtggcggata ttgtgaagga cgagcggcag catattgcgg
     2581 ttgtcaccgg ccggccaatg agtgttcctg tggtggatgc gaaaccgaca aaacgtccgg
     2641 gggtattcag tgtgtcgatt ccgggtctcc cgtctctgca ggtgagcgta cctaaaggtg
     2701 ttccggccgc gaaagccccg ccaaaaggca ttattgctga aaaaggtgat tcacgtccgg
     2761 ctggttttac ggccggtggt aactcccgtg aagccgttat tcgtttcccg aaagagagcg
     2821 gacagaaacc ggtctatgtg tcggtgacgg atgttcttac tccggcacag gtaaaacagc
     2881 gtctggagga agaaaagcgt cgccagcagg catgggacgc tgctcacccg gaagaggggc
     2941 tgaaaagaga gtatgataaa gcgaaagctg agctggatgc tgaagataaa aatattgcga
     3001 ccttaaacag tcgcattgca tcgacagaga aggcgatccc cggtgcaagg gctgctgttc
     3061 aggaagccga taaaaaggta aaagaggcag aggcaaataa agatgatttt gtgacttata
     3121 acccgcctca tgaatatggc tccgggtggc aggatcaggt tcgctatctt gataaggata
     3181 ttcagaatca gaatgagaaa ttaaaagctg cccagacatc tttaaacgaa atgaatgaat
     3241 ccttatccag ggataaggct gcgctttccg gggcgatgga gagccggaaa caaaaggaga
     3301 aaaaagcgaa ggatgcagaa aataaattaa atgaggaaaa gaaaaaacct cgtaagggaa
     3361 ctaaagatta cggccatgat tattttcctg atcccaagac tgaagatatt aaggggttgg
     3421 gagagttgaa agagggtaaa cctaaaaccc ctaaacaagg tggtggtggt aagcgggccc
     3481 gatggtatgg tgataaaaag cgtaaaattt atgaatggga ttcccagcac ggtgagcttg
     3541 aagggtaccg cgccagtgat ggcgaacacc tcggggcatt cgatccaaaa acgggtaagc
     3601 aggttaaagg gccggatcca aaacgaaaca ttaaaaaata tctttaagag gtaaatatgg
     3661 ggcttaaatt acatattcat tggtttgata agaaaaccga agagtttaaa ggtggtgaat
     3721 actcaaaaga cttcggtgat gatggttctg tcattgaaag tctggggatg cctttaaagg
     3781 ataatattaa taatggttgg tttgatgttg aaaaatcatg ggtttcgata ttacagccac
     3841 actttaaaaa tgtaatcgat attagtaaat ttgattactt tgtatccttt gtttaccggg
     3901 atggtaactg gtaagcaaaa gttatcaagg atgatttgaa atacagactt ccggtgttca
     3961 gggatgaata ccggggtttt taaatacagg gaaggtatat gaaaaaggta aaggttgttt
     4021 ttctttttat attgattttt tcaggctttc ttctggtcgc atgtcaggca aactatatcc
     4081 gggatgttca gggtggaacg gtggcaccat cgtcctcctc tgaactgacg gggatcgcgg
     4141 ttcagtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatcttttg
     4201 ccctgtaaac gaaaaaacca cctggggagg tggtttgatc gaaggttaag tcagttgggg
     4261 aactgcttaa ccgtggtaac tggctttcgc agagcacagc aaccaaatct gtccttccag
     4321 tgtagccgga ctttggcgca cacttcaaga gcaaccgcgt gtttagctaa acaaatcctc
     4381 tgcgaactcc cagttaccaa tggctgctgc cagtggcgtt ttgcgtgctt ttccgggttg
     4441 gactcaagtg aacagttacc ggataaggcg cagcagtcgg gctgaacggg gggttcttgc
     4501 ttacagccca gcttggagcg aacgacctac accgagccga gataccagag tgtgagctat
     4561 gagaaagcgc cacacttccc gcaagggaga aaggcggaac aggtatccgg gaaacggcag
     4621 ggttggaaca ggagagcgca agagggagcg attcatcgga aacggtgatg atctttaagt
     4681 cctgtcgggt ttcgccactc ctgactgatt catggttgag ccaccggctc ccacagatgc
     4741 accgaaaaag cgtctgttta tgtgaactca gtcaggaggg cggagcctat ggaaaaacgc
     4801 cacctgcgtg gccttgccgt tttgcctcac atgttagtcc cctgcttatt cacggaatct
     4861 gtgggtaact ttgcatgtgt ccgcagcgcc cgccgcagtc tcacggccgg agcgtagcga
     4921 ccgagtgagc gaggaggcgc aatttccccg gcacctacaa gacggacacc ggacgcgctg
     4981 atgtggcata ttgtcccctg attaagtctt tatattccct gataataaat taccaggata
     5041 ggtgaatcat atcggttttt cgctgaacat tttacgttaa cctatctctg ttgctttttt
     5101 ctccttacgg agaaatacag gtcatccccg cgagggcgtg gctgacctca gggggatatc
     5161 ccctgcttac gctggctgga cgccaccgac gcacggtctc tccccctctt tctggctccg
     5221 tccggctgga cgccggccac gccagaaatt cacccggccc ccgtcaggct cacgcctgac
     5281 cacccacaaa aatccacggt gctggacgca cctggcgaag cagcaaagct gctcctgatt
     5341 ttgcgggtgg tcagccgctc gctatggcga actctgacgg gggccggaac accggaaaag
     5401 accgcactgg ggtgccgcct tttcctctca cacgctgggg cgtgctcgtt gttcctccgg
     5461 ggctgcgcct tttccgcatg gggcggaaag aggctggcct ccgtggtgaa agctgaacgc
     5521 aatcaccacg gacgtgaccg ccgccgccat gccttggggc atgtccgcgg cttgtgcagc
     5581 gggggctgca catcacgccg gcaaaccatc gtctgaagga gagagaacat gtttaatacg
     5641 gattcgcttg cctggaagtg gcacattccg gagctggccc ggcagattta tccgtgggtc
     5701 agctggctgt accaggagta ttacggtctg gccggggctt tcctagttat cggcctgttt
     5761 ttcggtctgg ctgaactttg ggccggacgg atgcgttttg tggggctgag tcataaggag
     5821 cgacgggagt atgccgatcg ctataagcgc gataataaac ggccagcgcc attttcggtg
     5881 ctggcctcgc tggattcgcc cgggcggatg gtcagggcac gtcgacatgt ctggaactac
     5941 gcgtactggc tgaccggcgc ggccggtctg gcccttctgg gggggctggt tgtcgccgtg
     6001 tttatcgaga gctggggaga aaccgtcctg cgtccggacc tctacgcaaa cgcagattat
     6061 tacctgctgc agccggctaa cctgttcggg attgcctggt gcgcgggcgg gctggctgtc
     6121 gggattgtgt tggcgcggct gctggcgttc ctgctgcttg acggtcattt tgcggctgct
     6181 gacgaggcgg tgaacgcgaa actgaatcag gagagccggc gcagcagcca gcggacagga
     6241 gagatgaccg acgtgcgcca cctgcatttc ggggagccgg taccggttaa tgcgctggcc
     6301 gatttttcct cggagcaggc ccggcaggag caggcggtgt ttctgggtaa ggatgagcag
     6361 ggcaagccgg tgctggttcc gcgtgatacc tggcgcaaga ccaacattca gatcctcggc
     6421 ctgcccggga gcggcaagag cgtgatggcc accaacgcgc tcattcgctg cgtacgcgat
     6481 ttcggggacg cggtggtgta cttcgacccc aaaggggacg catgggcgcc gcacgtcttc
     6541 cgggcgcact gtccggactt caccctgctg gatctgcggc cggggaaacc ggcgcagctg
     6601 aatctgttcc gcgatctcga ccagtacgcg ctgaaaaacc tgctgattgc cgggcttaac
     6661 ctgggcgaga ccggcgacgt ggcggaccac taccgcatca gcgagcagaa agcggcgaag
     6721 ctgattgcgg agcagtttcc gcagggggca aacattcagc aggtgctggc ggcggcgtac
     6781 gcgctgccgg aggccctgaa aaaggacgtg aaggggttga tcactaggct ggaaaacgtc
     6841 gctgacctga gcgtcctgca gacggacagt ggcatcgatg tggcggggat tatcaacggc
     6901 ggcggctgcc tgtacgttat cggctcgatg gacgacgagg cggtgatccg tgtgcaaaaa
     6961 atgctgtttg cccgctgcgc gcaaatcatc attgcgcggg acgagttccg ggagtggcca
     7021 cacgtcagcg tgatgctcga tgaaattaaa tatctgctgt cgaagtatgt actgaacgca
     7081 ctggggacgc tgcgcagccg ggactgcaat ctgttgctcg cgcaccagtc gctgggcgat
     7141 ttcgggcagt gcgggcagga tctgcccgct gaatttgtga aaaccacggt actggataac
     7201 acgccgatcc gctggtttta ccgggcggcc agcctggagt ccgcgcagtg ggcggcgggg
     7261 cagaccgggg aaatcagggt ggacgtggag cgccgccgtg ccagccggga ggcggggaac
     7321 gtggagcata tcagcgggga cagcttcatc cagaaggagg cgcggccgct gtttgacgtg
     7381 aacaccctgc aacacctgcc ggacgggttc gcggtcatga ccgggctggg tgtggcccgg
     7441 atggcgttca gcagtccgct gcgggttgag cgccgggaaa tcccgttgca gcgtttcccg
     7501 gtgctggcga aaaccgatcc cctggcggag ttccggcccc cggccgacgg cggcgggccg
     7561 aaagcggatg atgattttgc ggggatttac tgatggcgct ggagctgtac aacgtcagcc
     7621 acgcgaaacg acaggcgcgg aacgcggaga aaacccggct gaccctgcgc tggttgcggg
     7681 aagagctgtg ttccacggcg gagctggttg cgcggcggct ggggattgcg gcggtgcagc
     7741 cggtctaccg cttcctcgac agcctggtgg cgaaagggct gctggtccgg accaaatatc
     7801 cggtggacgg ccgtcaggtc agcgtgtggg ggctgacgcc gcatggcgtg gcgttctcgt
     7861 tcgacgagga cgaaccgctg gcggatgtta ttccgtttca gccgtcaagg gtgtcggcag
     7921 cacatctgcc gcaccggctg gccgtgcaat ccctgcgcct tgatatggaa gccagagggg
     7981 ccaccggctg gcgcattctg caccgtctga gtcttaaagg catgaaagtg ccggacgccc
     8041 tggcggagct ggacggtaaa acggtggcgt ttgaggtgga gcgcaccgtc aagagccgtc
     8101 gccggtatca ggaagtggtg tccgggtatc tgttcaaccg caaagctaac ggcatcgatg
     8161 aaatctggta catctgcccg gaccgggcga cgcaggtcag ggtgcagcgg gcaatcctgt
     8221 cggtggatga aatcgtgaac ccacagaccg gcgaggcccg caaaacggca gagctggatc
     8281 gtgaacggtt gtttgcgtgc tttaaattta tgacaacgga gtgagggatt atggcgctgt
     8341 acatggtatt tattgaagac gcggaggacc ggaacggcga gcgctgcatc atgccgacca
     8401 gcgagcatct ggaagatatg gtggtgctcg cctggcagac cggggcgtat gttttctgtt
     8461 ttgtcgaccg ggcccagcat ctggcgatga tgaaatccat cgggatgtat gacgagcggc
     8521 tcaacagcga cgaaaaagcc acgtactttt tcactggtaa aaatccgcaa tgggaacgga
     8581 acaaacccac aggaatgaag ctgtgtgatt acctctatcg caaggtggag cggttcgcca
     8641 tcgagaacgg tgtgcaggtg gttgatgccg ggaagtgctc accggagcag attaacgcga
     8701 tgattgacgt ggtgagtgag cggcacgggg aaagcgcggt gaacgagaag ctgaaagcgg
     8761 agctgatgcg ggaatataac agccgctatt ttaacgtgcc ggtacctgaa ctgccggagg
     8821 acaaacctgc ccgccggtgg tggccgttcg gcaaaaaata aatgccagca ccggccatgc
     8881 cggtgctgtt attcctcccc gagcttatcc cgcatcacct gccagagtgt ttccgcatcc
     8941 tcgtgtagcc gctcgcacat gtcggccggg gtatccatat ccagctcatt cagtttatcg
     9001 agcaatagca gcgactgctc cttaataaat ttagccatat tgagggctgt tttttcctgt
     9061 tttgtcatga ttctttcctt ccgggcatgg tgtgcgcctg tcaggtatac tgtctcaaaa
     9121 atagcggggt gagacaatgg cgtgggtgac ggtgagacag gcgacggaac tgacgggtaa
     9181 agcccgaagt tccctgtatc gggatatggc gaaaggccgc gtatcatacc gtacggaagc
     9241 tgatggcggc cgggtggtgg ataccagcga gcttatccgg gtgtacggtg agtt
//
