LOCUS       NZ_CP018067            29012 bp    DNA     circular CON 31-JAN-2024
DEFINITION  Enterococcus faecium strain E1 plasmid pE1_29, complete sequence.
ACCESSION   NZ_CP018067
VERSION     NZ_CP018067.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN06019998
            Assembly: GCF_001886635.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 29012)
  AUTHORS   Tedim,A.P., Lanza,V.F., Manrique,M., Pareja,E., Ruiz-Garbajosa,P.,
            Canton,R., Baquero,F., Coque,T.M. and Tobes,R.
  TITLE     Complete Genome Sequence of E. faecium ST117 a globally disseminated
            multidrug resistant clone
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 29012)
  AUTHORS   Tedim,A.P., Lanza,V.F., Manrique,M., Pareja,E., Ruiz-Garbajosa,P.,
            Canton,R., Baquero,F., Coque,T.M. and Tobes,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-NOV-2016) Microbiology Laboratory, Instituto Ramon y
            Cajal de Investigacion Sanitaria (IRYCIS), Carretera Colmenar Viejo
            km9.1, Madrid 28034, Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 800.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/31/2024 03:04:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,196
            CDSs (total)                      :: 3,103
            Genes (coding)                    :: 3,003
            CDSs (with protein)               :: 3,003
            Genes (RNA)                       :: 93
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 100
            CDSs (without protein)            :: 100
            Pseudo Genes (ambiguous residues) :: 0 of 100
            Pseudo Genes (frameshifted)       :: 35 of 100
            Pseudo Genes (incomplete)         :: 65 of 100
            Pseudo Genes (internal stop)      :: 25 of 100
            Pseudo Genes (multiple problems)  :: 19 of 100
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP018067.1.
            Bacteria and source DNA available from Teresa Coque. Hospital Ramon
            y Cajal. Microbiology department.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..29012
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="E1"
                     /isolation_source="Blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="pE1_29"
                     /geo_loc_name="Spain: Madrid"
                     /lat_lon="40.48 N 3.69 W"
                     /collection_date="2010-01-11"
                     /collected_by="Hospital Ramon y Cajal. Microbiology
                     Department"
                     /subtype="ST117"
                     /subgroup="BAPS2.1a"
     gene            172..852
                     /locus_tag="BO233_RS16560"
                     /old_locus_tag="BO233_15535"
     CDS             172..852
                     /locus_tag="BO233_RS16560"
                     /old_locus_tag="BO233_15535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001067799.1"
                     /translation="MNPFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            <904..1473
                     /locus_tag="BO233_RS16565"
                     /old_locus_tag="BO233_15540"
                     /pseudo=""
     CDS             <904..1473
                     /locus_tag="BO233_RS16565"
                     /old_locus_tag="BO233_15540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010769338.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /name="FtsX-like permease family protein"
     gene            1874..2479
                     /locus_tag="BO233_RS16570"
                     /old_locus_tag="BO233_15545"
     CDS             1874..2479
                     /locus_tag="BO233_RS16570"
                     /old_locus_tag="BO233_15545"
                     /EC_number="2.7.7.108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016176895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein adenylyltransferase Fic"
                     /protein_id="WP_000599739.1"
                     /translation="MILENKLGLTNQVELAKVEEKLSKQKAKELYDCGKINEIEVGTFK
                     GLSEIHEFLFSDIYDFAGKIRSVNIAKGNFRFAPVMYLEHSLQHIDQMPQTSFEEIIKK
                     YVEMNIAHPFREGNGRSTRIWLDLILKEELQKVVDWNLIDKADYLSAMERSPINDLEIR
                     YLISNALTDKIDDRELYMKGIDVSYFYEGYSEYTIDDL"
                     /name="protein adenylyltransferase Fic"
     gene            2495..3067
                     /locus_tag="BO233_RS16575"
                     /old_locus_tag="BO233_15550"
     CDS             2495..3067
                     /locus_tag="BO233_RS16575"
                     /old_locus_tag="BO233_15550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170424.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000170424.1"
                     /translation="MTKYGYARVSTASQSTKEQIQQLLENGVEKKNIFSEKFTGTKRDR
                     PKFNQLLAGLKPGDEIVVTKLDRFARNTREALEIIEPLLDDNVTIKVLNLGTIENTSMG
                     RMVTRTLLSVAEMERDMIVERTQEGKMFARKNNPNFREGRPKATITPKKRHAYELLTSG
                     KSYKEVEAITGFSRSTLFRIKKKIEES"
                     /name="recombinase family protein"
     gene            complement(3319..3576)
                     /locus_tag="BO233_RS16580"
                     /old_locus_tag="BO233_15555"
     CDS             complement(3319..3576)
                     /locus_tag="BO233_RS16580"
                     /old_locus_tag="BO233_15555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002326781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002326781.1"
                     /translation="MANLYIENKGDLNAIITLIVVMVKSIGNITIGMLFIILAAVLIFM
                     IVIWFLNERSKDNQHRRDMEIKSIESIDYLSIITLKKPRS"
                     /name="hypothetical protein"
     gene            complement(3702..4517)
                     /locus_tag="BO233_RS16585"
                     /old_locus_tag="BO233_15560"
     CDS             complement(3702..4517)
                     /locus_tag="BO233_RS16585"
                     /old_locus_tag="BO233_15560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002326780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_002326780.1"
                     /translation="MVKIAGLSKGGKTVSQLYKQNYRDWRQFRKNIKDSYFILPTELEK
                     YLPNNKAINLYLYYCFKAKNEGGDSWHSVNTIAESLGVTTKTINTWNKTLVDLGMIARI
                     DDNHLSKSTILLPLSSYYKLALDSSLKDVTESTVHEIDGNLVAVYHLFEWRKNEADENY
                     NVPYNTLCCVFKRKTQKDTIYKFILVQDEKISNFELSTPSSKIYDDAYRFECQDLEALL
                     SANNLNNIEHENFVVNTRFNLVSEKDSDLLDLLIELTKNLDKKENITVL"
                     /name="helix-turn-helix domain-containing protein"
     gene            5034..6359
                     /locus_tag="BO233_RS16590"
                     /old_locus_tag="BO233_15565"
     CDS             5034..6359
                     /locus_tag="BO233_RS16590"
                     /old_locus_tag="BO233_15565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="WP_002342448.1"
                     /translation="MMDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRAD
                     NTGSGLILASSPAAKKKYGISNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTRSMNLFTTEGTRSQRRKKLAQMIQENIKEELGLLATVG
                     VGDNPLLAKLALDNEAKHNDGFLAEWTYQNVPDKVWNIPEMTDLWGIGSRMKKRLNQIG
                     IMSIKDLANWNPYTIKSHLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLYIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSDPQKQIDEENLDKIIDK
                     IRQKYGFTSIVHASSMLEGARSITRSTLVGGHAGGAGGLKND"
                     /name="Y-family DNA polymerase"
     gene            6352..6702
                     /locus_tag="BO233_RS16595"
                     /old_locus_tag="BO233_15570"
     CDS             6352..6702
                     /locus_tag="BO233_RS16595"
                     /old_locus_tag="BO233_15570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002326767.1"
                     /translation="MIDYNDRGRLKWAGFYLSDHTEKIDADNEQRANQNLAKEQMTTEE
                     VAEVLNAAVIKNRSVCIQKEERNAEGYYPEDIVSKILGSDELGIYVGKNKVHYDEIRHI
                     EFYQDNKWGRLE"
                     /name="hypothetical protein"
     gene            6699..6869
                     /locus_tag="BO233_RS17345"
     CDS             6699..6869
                     /locus_tag="BO233_RS17345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016631600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_073490843.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEAAA
                     GYHKYEYYIGY"
                     /name="hypothetical protein"
     gene            complement(7773..8048)
                     /gene="prgO"
                     /locus_tag="BO233_RS16605"
                     /old_locus_tag="BO233_15580"
     CDS             complement(7773..8048)
                     /gene="prgO"
                     /locus_tag="BO233_RS16605"
                     /old_locus_tag="BO233_15580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA segregation protein PrgO"
                     /protein_id="WP_001196543.1"
                     /translation="MALLPTNKDKKKIGAEDISIKDDINVELGERKYTAKERKPVQVDP
                     PVLKTIRDLSYAKDIPMYEIVKLAMDAYVDTLNDEERIIYNRRSKD"
                     /name="prgO"
     gene            complement(8020..8973)
                     /locus_tag="BO233_RS16610"
                     /old_locus_tag="BO233_15585"
     CDS             complement(8020..8973)
                     /locus_tag="BO233_RS16610"
                     /old_locus_tag="BO233_15585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016623100.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="WP_000429439.1"
                     /translation="MENLRTAFKTSDKLGKVVMLTGRKGGIGKTTDNDLLAIVSSQLFE
                     KDVLLIDYDQQRNTTSNIGSTYQITSFDRSMSAAIKKGDWVSGITQVSPHLYIMAGSPG
                     SEELNEYLSEKYPDRRKRSLAFIKPLEELRKNFDYIFIDCPPSTDNVVRAFLTAADYII
                     AMQELKRYAMEGTEDFINKVLVPIVTNFEESHLQIIGILPVLFSVRRSSQHANYQKTID
                     KYGESNIFKSIVKGSDRLEMYGENGIQLNDYVDRRWWAIFADIFTELEERIEYYEQHGD
                     IEGFDYTPKYADSMANHILPLGKEIKLNGIITNEQR"
                     /name="ParA family protein"
     gene            9585..11078
                     /locus_tag="BO233_RS16615"
                     /old_locus_tag="BO233_15590"
     CDS             9585..11078
                     /locus_tag="BO233_RS16615"
                     /old_locus_tag="BO233_15590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000947690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primase C-terminal domain-containing protein"
                     /protein_id="WP_000947691.1"
                     /translation="MLSEIYSAILKNGLRTYKYRNSTMKPAGHIDSSRSGAIFAYRSKQ
                     LMNVGRGMVITSEEAILENEKKLTHWTPNTYRFGTYADDYRTVVKGHSEKNLSQINTFV
                     VDIDSKENHQGEIILACLDQVGYMPTLILESDHGYQVYFVLKTPGYVTKKSNFKVIDVA
                     KKISKTIRLQLAEKLSGVDLGCNHFGIARFPQENNIVFKEMNYQYSFADWIQWSMKLES
                     DQKTKEDRERKLIVFPEKKEIRQVDEPWFDMLLHKANIVGGEGRLGRNNVIFTLSLAYY
                     SSGYALDTCEYNMFTFNERLQEPLSEAELVKIVRSAYSGNYQAASREFIIELCQQWVSP
                     TLKNNDLFIQRRGWWKFKKPRDQRKYSHKNEWKEDLLAYLSEKSLASEPYLNLSKKELA
                     SQLTMPKRTLDKILNELREENKVFYKVTRGRNGGMIIASVKTLFARVIQLSKEKRLDYS
                     TRITEVFGLNESLVEETFRQLSTPLNPLKEVNLFEVDTG"
                     /name="primase C-terminal domain-containing protein"
     gene            11213..11509
                     /locus_tag="BO233_RS16620"
                     /old_locus_tag="BO233_15595"
     CDS             11213..11509
                     /locus_tag="BO233_RS16620"
                     /old_locus_tag="BO233_15595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication control protein PrgN"
                     /protein_id="WP_000053907.1"
                     /translation="MSLKNYVYSHPVNVFIIGRLGLSVEVFCELYGFKQGTLSSWVTRE
                     KTVASLPIEFLHGLSLASGETMDQVYDCLCVLEQEYIEYKIANELRKRKKYIQ"
                     /name="replication control protein PrgN"
     gene            11610..12461
                     /locus_tag="BO233_RS16625"
                     /old_locus_tag="BO233_15600"
     CDS             11610..12461
                     /locus_tag="BO233_RS16625"
                     /old_locus_tag="BO233_15600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002338002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002287227.1"
                     /translation="MKSDDWIEHTWLPLKRNSKRKKFWVLQLWPLGKLCSYGARLILDL
                     TVYSIGVFGTAYYLINDPNRIAASDIFTVLMTLIFVMLLSIFTQLVMQFTRQKLTAGKL
                     FKSLFDLIVVNAILATLIKQIEQSGRTTKGVKDFLLTFIHFVNGHMYLFEVGIILFFVG
                     YVSTKLIKRSIEKEIEIDLIPTLLGYEYNVDFGRYDELINTDIVHTSIHESTVKGIRSI
                     LKNGQEMKAIDRRKEIYNFYEVEASLRYGIGKLWLDGSNIRQNKPYIFWNSSDLELPMK
                     DK"
                     /name="hypothetical protein"
     gene            12482..12694
                     /locus_tag="BO233_RS16630"
                     /old_locus_tag="BO233_15605"
     CDS             12482..12694
                     /locus_tag="BO233_RS16630"
                     /old_locus_tag="BO233_15605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002324171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002324171.1"
                     /translation="MIPLYRIVLIVGMELKTLKKEQLFKVKERHNQLLCSKTGTMNIEY
                     RTEYLELTNQTDFLLIRKQQEQEKN"
                     /name="hypothetical protein"
     gene            13127..13807
                     /locus_tag="BO233_RS16635"
                     /old_locus_tag="BO233_15610"
     CDS             13127..13807
                     /locus_tag="BO233_RS16635"
                     /old_locus_tag="BO233_15610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001067799.1"
                     /translation="MNPFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(13841..14128)
                     /locus_tag="BO233_RS16640"
                     /old_locus_tag="BO233_15615"
     CDS             complement(13841..14128)
                     /locus_tag="BO233_RS16640"
                     /old_locus_tag="BO233_15615"
                     /inference="COORDINATES: protein motif:HMM:NF025079.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4158 domain-containing protein"
                     /protein_id="WP_060763464.1"
                     /translation="MDEIKSNKKAFGIYLGEPSTEQLNQFFYLHEKDLELMETIRRPAT
                     RLGFALQLVSLRFLGTFILDLTNIPQNVLSYVATQLNIDPGEIIGSVAKF"
                     /name="DUF4158 domain-containing protein"
     gene            14253..14858
                     /locus_tag="BO233_RS16645"
                     /old_locus_tag="BO233_15620"
     CDS             14253..14858
                     /locus_tag="BO233_RS16645"
                     /old_locus_tag="BO233_15620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002321606.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_002321606.1"
                     /translation="MGKIGYIRVSSQDQNLDRQLAMMEGLNIDKLFQEKASGKDTERPE
                     FQKLLNYIREGDCVIVTSLDRLGRDYEDIKNTVAFMKQKKVALKILDAQFLDFNTGNEL
                     LDTAMFDMFLSLLSYIAQNEREKIRERQRQGVLLAQKAGRYKGRPIEYSINSTDPQKRL
                     VFKTVVDMLKQGIPVAEIAKENGISRPTIYKIKKANDL"
                     /name="recombinase family protein"
     gene            complement(14903..15556)
                     /locus_tag="BO233_RS16650"
                     /old_locus_tag="BO233_15625"
     CDS             complement(14903..15556)
                     /locus_tag="BO233_RS16650"
                     /old_locus_tag="BO233_15625"
                     /inference="COORDINATES: protein motif:HMM:NF012706.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_224813426.1"
                     /translation="MKRTWGKNLTILMLGIIITGCGEKSQETAKETKAYTFAVSTTVQS
                     LDPKLAIDPTSQLVLNNVMEGLYKLNAKGEIVPGGANGLPEISKDGLKYVIRLRKDAMW
                     SNGTPVVADDYVYSWKRTLSNQDSPNIGFFESIKNGKEIISGTMKPDKLGVYAKDKNTL
                     VINLSTPIPYFTSMLINTAFFPQKQEVVEKEGDRYGTNSDSVIYNGPYIGVHGT"
                     /name="ABC transporter substrate-binding protein"
     gene            15845..16237
                     /gene="merR"
                     /locus_tag="BO233_RS16655"
                     /old_locus_tag="BO233_15630"
     CDS             15845..16237
                     /gene="merR"
                     /locus_tag="BO233_RS16655"
                     /old_locus_tag="BO233_15630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020220203.1"
                     /GO_function="GO:0001228 - DNA-binding transcription
                     activator activity, RNA polymerase II-specific [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Hg(II)-responsive transcriptional regulator"
                     /protein_id="WP_001863748.1"
                     /translation="MIYRISEFADKCGVNKETIRYYERKNLLQEPHRTEAGYRIYSYDD
                     VKRVGFIKRIQELGFSLSEIYKLLGVVDKDEVRCQDMFEFVSKKQKEVQKQIEDLKRIE
                     TMLDDLKQRCPDEKQLHSCPIIETLT"
                     /name="merR"
     gene            16266..18161
                     /gene="merA"
                     /locus_tag="BO233_RS16660"
                     /old_locus_tag="BO233_15635"
     ARG             16267..18158
                     /name="merA"
                     /gene="merA"
                     /gene_name="mercury(II) reductase"
                     /tool="amrfinderplus"
                     /drug_class="MERCURY"
                     /identity="96.04"
                     /coverage="100.0"
     gene            18321..19643
                     /locus_tag="BO233_RS16665"
                     /old_locus_tag="BO233_15640"
     CDS             18321..19643
                     /locus_tag="BO233_RS16665"
                     /old_locus_tag="BO233_15640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001281642.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="WP_060763465.1"
                     /translation="MSDLLSLPDIKTIEPPQENETDMMFKVEAVGPPERCPECGFDKLY
                     KHSSRNQLIMDLPIRLKRVGLQLNRRRYKCRECGSTFWERLISVDEKRSMTKRLLKSIQ
                     EQSMSKTFVEVAESVGVDEKTIRNVFKDYVALKEREYQFETPKWLGIDEIHIIRRPRLV
                     LTNIERRTIYDIKPNRNKETVIQRLSEISDRTYIEYVTMDMWKPYKDAVNPILPHAKVV
                     VDKFHVVRMANQALDNVRKSLKAHMSQKERRTLMRERFILLKRKHDLNERESFLLDTWL
                     GNLPALKEAYELKEEFYWIWDTPDPDEGHLRYSQWRHRCMSSNSKDAYKDLVRAVDNWH
                     VEIFNYFDKRLTNAYTESINSIIRQVERMGRGYSFDALRAKILFNEKLHKKRKPRFNSS
                     AFNKAMLYDTFNWYEVNDHDITDNFGVDFSTPIKNLEKGDL"
                     /name="ISL3 family transposase"
     gene            complement(19770..21275)
                     /locus_tag="BO233_RS16670"
                     /old_locus_tag="BO233_15645"
     CDS             complement(19770..21275)
                     /locus_tag="BO233_RS16670"
                     /old_locus_tag="BO233_15645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002360897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primase C-terminal domain-containing protein"
                     /protein_id="WP_060763466.1"
                     /translation="MKVSDVISVILKSGIREYKCLNSKIKPIGYKAEGKKGAIFGFRSK
                     KLMTESRGIVLTSQEGLAENEDKFTHWTPNVYSYGAYADEKRIIVKGHNERNLQQINTF
                     VIDFDRLTGEKLDSQMILDAAIDLELMPTLILETPGGFQAYFILENAWYISSKNNYQSI
                     EVAKRVSENLRKAFAEELPSVDLGCNHFGIARIPRTDNIVYYYPALTHDIQQLIQWSMK
                     YEPAKTYKKPLLSLVKNKYKQVNEMWYRQLISNPKIVGAKGIMGRNNVIFTLSLANYAS
                     GVDLEDCLNEMDLFNSSLERPLKDRERVRIVKSAYSGKYRGASKTYVQELVSNWGLESL
                     SEEKMFTQQRNTWYKFKKERHKRKKSHLSEWKEDILAYLETQCYRYRPEVRLKKTDLQA
                     AITFNGQSIPKRSLDRALKELMAEGKLFVQIKAGRNGGLVVATRKALIRTVIQVKQQVK
                     SAYKQGIKTFFKEADMLVRIFREPDKYSQRVDHYKQLNLWNTG"
                     /name="primase C-terminal domain-containing protein"
     gene            21979..22869
                     /gene="prgP"
                     /locus_tag="BO233_RS16675"
                     /old_locus_tag="BO233_15650"
     CDS             21979..22869
                     /gene="prgP"
                     /locus_tag="BO233_RS16675"
                     /old_locus_tag="BO233_15650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016615412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA superfamily DNA segregation protein PrgP"
                     /protein_id="WP_010714376.1"
                     /translation="MANTIIFGQQKGGVGKTTDTCMITLVAAMLMKKRTILIDIDLQAN
                     ATNFMTKTFGVETVPQTLMSALENGDLRPAIVNLKENLDLIPAGYDMRLYTEFLTENFD
                     NTIDRTFYLKNLIEEIKDDYDYIFIDIPPSTDLKVDNAMVACDYLVVVQETQQFSFEGS
                     QRLIFDYIQTLVDDFGSDVPIQIAGILPALLQQKRPMHQKLVEETIDTFGRDNVFNTII
                     QNHARLEWYPRIGFQFQDYHDKKMIALFADIFCELEERITLYKSNGDIQDYFYTPRYIL
                     DGKLTSLGKEISLNV"
                     /name="prgP"
     gene            22862..23146
                     /locus_tag="BO233_RS16680"
                     /old_locus_tag="BO233_15655"
     CDS             22862..23146
                     /locus_tag="BO233_RS16680"
                     /old_locus_tag="BO233_15655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002412979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_010714377.1"
                     /translation="MSSLINRKIPQGATANKEADTKRKVTIQKKSSKKILASERKNIKV
                     SPSTFDLIKTISTMKSYKNYEFIDKAVESYIQNNLTEREQRILKNLISK"
                     /name="hypothetical protein"
     gene            complement(23179..23511)
                     /locus_tag="BO233_RS16685"
                     /old_locus_tag="BO233_15660"
     CDS             complement(23179..23511)
                     /locus_tag="BO233_RS16685"
                     /old_locus_tag="BO233_15660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002406176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF6440 family protein"
                     /protein_id="WP_010714745.1"
                     /translation="MPLTLILGGEYIYYDKNLGMMVAGDNSNSELIEQSDNVPLDRHKC
                     KEHVFKDKRFVEKESESLTLLGYKIVVDTVTGVNYLETPKGGITPLLDKNGKICIDKKK
                     SINKKG"
                     /name="DUF6440 family protein"
     gene            complement(23814..24011)
                     /locus_tag="BO233_RS16690"
                     /old_locus_tag="BO233_15665"
     CDS             complement(23814..24011)
                     /locus_tag="BO233_RS16690"
                     /old_locus_tag="BO233_15665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002412976.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_048669782.1"
                     /translation="MKRKSYDRWGIEITSFNRNIAFHVECDCGELAKSVYQKNYFYCPK
                     CHRRYKQKQGEYVAITIIKE"
                     /name="hypothetical protein"
     gene            complement(24045..24344)
                     /locus_tag="BO233_RS16695"
                     /old_locus_tag="BO233_15670"
     CDS             complement(24045..24344)
                     /locus_tag="BO233_RS16695"
                     /old_locus_tag="BO233_15670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000366408.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BRCT domain-containing protein"
                     /protein_id="WP_000366408.1"
                     /translation="MDLTNQRVVFTGTLQQMTRTQAIGLVHSLNGHCQSSVTSKTNFLV
                     CGQYSKSLFDDSLYTKKEQTARDLIALGHEITILSEVEFYALISQQLKEWQRYL"
                     /name="BRCT domain-containing protein"
     gene            complement(24385..25002)
                     /locus_tag="BO233_RS16700"
                     /old_locus_tag="BO233_15675"
     CDS             complement(24385..25002)
                     /locus_tag="BO233_RS16700"
                     /old_locus_tag="BO233_15675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001224538.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001224538.1"
                     /translation="MRKFFYIRVSSYDQSIERQLISAKELGIPEEYIFVEKASGKDFKR
                     PEYQLMKRMFRKGDLLYLQSLDRLGRNKQMILEEWRELTKEKQIDISVLDMPLLDTASY
                     KQLDGLETLISDLILQLLSYMAEDERKRINSRQREGVEAAKQKGVKFGRKKIALPPEFP
                     AIYSDWKAGKITAVYAMDQLGMKRNTFYRRVKEYEHTLHHFS"
                     /name="recombinase family protein"
     gene            complement(25327..25722)
                     /locus_tag="BO233_RS16705"
                     /old_locus_tag="BO233_15680"
     CDS             complement(25327..25722)
                     /locus_tag="BO233_RS16705"
                     /old_locus_tag="BO233_15680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002304891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002304891.1"
                     /translation="MMIMEEIEWNNLTQNNKNNSGCGIIFMFVIVLGIVVLLITVKIVD
                     YFANTPEEQIQRKLPEFERVPPYDPRDNSFQVKKLKESPNEMWFEVTVESSDFKEKKKE
                     YNYIVKAKVSKRFIFNPKLEIYSVVIE"
                     /name="hypothetical protein"
     gene            complement(25802..28153)
                     /locus_tag="BO233_RS16710"
                     /old_locus_tag="BO233_15685"
     CDS             complement(25802..28153)
                     /locus_tag="BO233_RS16710"
                     /old_locus_tag="BO233_15685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000344083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase domain-containing protein"
                     /protein_id="WP_000344083.1"
                     /translation="MDEMVLSTQKWLNKKYSNVTGFDKVPENGRTGWPTIYGLIEGLQV
                     ELGITNLVANFGPTTEKMYDNQVTPKWGKNLPKNIVFLIQGAFWCKGINPGGFDGVYTP
                     YLDTAVKELQTDAGFNGSAVTGVLDAKWAKALFDMSAFVLVPGGDSKIRKMQQWLNVNY
                     LEYTGIMPCDGIYQRNSNQALIFALQAELGYSPSEATGSYGNGTTSKTYPVSEGNSGNY
                     VRIIQYGLYVNGYFEDGTFDGIFTKYMGLEVLAFRKFMVLPEYTEIADVVVIKGLLSSA
                     GDIRRSADGADTSTQLTRSQIQTLVDNDIKIVGRYLTGTVGIGKDERNKYLTTEELNNI
                     FSKNLSVFPIYQDGGAALAYFTYDRGLSDGKKAIDAAKNLNIPLTTVIYFAVDLDMLGE
                     EILAYAGEYFKGVSAVMSYSGYQTGVYGTRNVCSQIINNGYASFAFVSDMSTGYSGNLG
                     FPMPRQWSFDQFVEFTIGSGNGAVGIDLIATSGRDSGFNELSNDTNNDNYIAKYNQKVI
                     NQMVRAYQYLSQAGLDNPWNPHLTFYRYVNYSGLSWDIISSPVTEHDRKIYDEYRNKLT
                     NSEGLYNYFIDPNTGSIIGLPHLIVTLQSQMFLADTINDSVSDFAGWLGDLMTCWGEVK
                     KLGIQMEQGVFALVGTAAGGTFSLEDLYQDVDAVNVYTLAKRNSDSTALSALKTYYCDK
                     GAIDRFNQFVKNRFGSSDKIASVTNSLLENDETVDILGVGIISFFIDKIVNNSLGTDFT
                     YLDFIGDEGKVANGFSEKIIQFQENRSKLN"
                     /name="glycoside hydrolase domain-containing protein"
     gene            28278..28958
                     /locus_tag="BO233_RS16715"
                     /old_locus_tag="BO233_15690"
     CDS             28278..28958
                     /locus_tag="BO233_RS16715"
                     /old_locus_tag="BO233_15690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001067799.1"
                     /translation="MNPFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     Typing          9586..11078
                     /name="rep_cluster_185"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(19778..21275)
                     /name="rep_cluster_180"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="84.687"
                     /coverage="99.0"
                     /evalue="0.0"
ORIGIN
        1 tatttcttgt ttagccattt ctgagtactt aaaaccatct catccataaa aatcccctgc
       61 tttcttgccg aacatacgtt cgtttatgtg ttgattaggt tctgttgcaa agttttaaat
      121 ctactatcaa ataaggtaga ataatagaaa aagatagcag gaggaatgac gatgaatcct
      181 tttaaaggaa agcaatttca gcaggatgtg attattgtag ccgtgggcta ctatcttcgt
      241 tataacctta gctatcgtga agttcaagaa atcttatatg atcgtggcat taacgtttct
      301 catacgacga tttatcgttg ggtgcaagaa tatggcaaac tactctatca aatttggaaa
      361 aagaaaaata aaaaatcctt ttattcatgg aaaatggatg aaacgtacat caaaattaaa
      421 ggaaaatggc attatttgta tcgagccatc gatgcagatg gtttaacctt ggatatttgg
      481 ttacgtaaaa aacgggacac acaagcagcc tatgcttttc ttaagcggtt agtgaagcag
      541 tttgatgaac cgaaggttgt agtcacagat aaagccccct ctattacaag tgcctttaag
      601 aaactaaaag aatacggctt ttatcaaggg acagaacatc gtaccattaa atacctgaat
      661 aatttgattg aacaagacca tcgtccagta aagagacgca ataaattcta tcgaagttta
      721 cgcactgcct ctaccacgat taaaggcatg gaagccattc gaggattata taagaaaacc
      781 cgaaaagaag gcactctctt cgggttttcg gtctgtactg aaatcaaggt attattggga
      841 atcccagctt aaatcataga taccgtaagg gattttattc tttatttaaa actttgcaac
      901 agaacctatt attttaagtc tgaaaaggat acatcgtctc taacgttaac tttagaggaa
      961 ggagttgaac ctgacaaggt gacctctaaa gtgataaacc aattgaaaga aaaaggtagt
     1021 ttgaaacatt tgggggaata tgaagtgtta gatacggcta tgttaacgaa aggaattggt
     1081 caaatcctca gtacgatcac ttattttata acagctgtag caggtatatc tttatttatc
     1141 gcaggggtag gtgtaatgaa catgatgtat atatctgtat ctgaacgaac aaaagagatc
     1201 ggtataagaa gagccctagg agctactcga aaatcgatta tgctgcagtt ccttttagaa
     1261 ggtttgattt taactctttc aggagggtta attggctatt tattaggaat ggctcttgct
     1321 tatagtgttg gttctttgat aaaggtaaac gtgtcacttg atctatttac tattttacta
     1381 gcggttgggg tatcttcggt tattggactg gtcttttctg taatgcccgc ttcagaggct
     1441 gcaaaaaaag atttaattga tattcttaga taaaatcaga atgacaagaa tatttacgtt
     1501 ctagattcta aaataaaaca caaagagacc aaccaggcac cctattgttt ctttgtagta
     1561 tagagatatt ctttggcttg taagagatca atagagttag gtgaccggag ttcgaaataa
     1621 aggaaatttt tgattgtata ggagaattct ttatccctaa tatttagaat tttgagtatg
     1681 ccatgttgat gttttagatt ctctataaat atagaggtgt atcaaaggtc aactagactg
     1741 tgcaaaatag agacacttga aaaatctatc gggggtcaga aacttaatag tttttgacac
     1801 ataaacaaaa tcgcgatata atggggttga gagtgtttca taaacttatg tcataaagtt
     1861 aaggagattt cgcatgattt tagagaataa attgggatta accaatcaag ttgagttggc
     1921 taaggttgaa gaaaaactca gtaaacaaaa agcgaaagaa ttgtacgatt gtggaaaaat
     1981 aaatgaaatc gaagttggta catttaaagg tttatctgaa attcatgaat ttctattttc
     2041 ggatatttac gattttgccg gaaaaatccg atcggtcaat attgcaaaag gaaattttcg
     2101 atttgcacca gttatgtatt tagaacattc gttacagcat attgatcaga tgccacaaac
     2161 ttcttttgaa gagattatca agaaatatgt ggagatgaat atcgctcacc catttcgaga
     2221 aggaaatggc cgaagtacta gaatttggct ggatctcatt ttaaaggaag aattgcaaaa
     2281 agttgtagat tggaacttaa tcgataaagc agactatctt tctgcaatgg agcgaagtcc
     2341 cataaacgat ttggaaatac gctatctaat ttccaatgct ctgactgata aaattgacga
     2401 tcgcgagtta tatatgaaag gaatcgatgt cagctatttc tatgaagggt attctgagta
     2461 tacgatagat gatttgtaaa agtaggtgga ccaaatgacg aaatatggat atgcacgtgt
     2521 ctcaaccgct tctcaaagta caaaagaaca aattcaacag ttgcttgaga acggcgtaga
     2581 gaagaagaat attttttcag aaaaatttac gggtacaaaa cgggatcggc caaaattcaa
     2641 tcagctgttg gctggtctga agcctggaga tgaaatagtt gttacgaagc ttgatcgatt
     2701 tgctcgtaac acgagagaag cattagagat cattgaacct ttactcgatg ataacgtaac
     2761 gatcaaggtt ttgaatctag gaacgattga aaatacgtcc atggggcgaa tggtgacacg
     2821 gacgttgttg agtgtagcag aaatggaacg tgatatgatt gtggaacgta cccaagaagg
     2881 aaaaatgttt gcaagaaaga ataatcctaa tttcagagaa ggacgtccga aagcaacaat
     2941 cacaccgaag aagaggcacg catatgaact gcttacttca ggtaaatcgt ataaggaagt
     3001 tgaagctata accggtttca gtcgcagtac gctttttaga ataaagaaga aaattgaaga
     3061 aagttaaaaa agaagtctca gcgaaccaga caggtaaata cttaatgcgt tctagatatg
     3121 agtctattag catgttgtga aatataatat ttttttattt acttgatttc tgctcaaaaa
     3181 atgtgtatgg taactgtaaa aggtaaagta attaaaggta tgctagccac gcttactata
     3241 ttaggatacc atcatatatt tataatgaac gatttgttcg tctaccaaac aacacatatc
     3301 gttcagcgta agtcacgttt aggaacgtgg cttttttagt gttattatcg ataaataatc
     3361 tattgactct attgatttta tctccatatc cctacggtgt tgattgtctt tagatctttc
     3421 atttaagaac caaataacta tcataaaaat cagcactgct gctaatataa taaacagcat
     3481 tcctattgtg atattaccta ttgattttac cataactacg attaaagtaa taatggcatt
     3541 caagtctcct ttgttctcta tatataaatt agccataaat catcttcctt tcaaattaag
     3601 atacttgttt gataccaata aatagtaagc gtggctagca tacctttttc tgtaatagca
     3661 agtgttctaa tagtccaaac ttaatgatgg accgatgcta gttatagtac agtaatgttt
     3721 tctttcttat ctagattttt agtaagctct atcagcaaat ctaacaaatc tgagtccttt
     3781 tcagaaacta aattaaatct agtgtttaca acaaagtttt catgttctat attgtttaga
     3841 ttatttgcgg aaaggagggc ttctagatct tgacattcaa atctatatgc atcgtcataa
     3901 atcttactag aaggagtgct taattcgaaa ttacttattt tctcatcttg gaccaagata
     3961 aatttataga tagtatcttt ttgtgttttt cttttaaaaa cacaacagag tgtgttataa
     4021 ggaacgttat aattttcatc agcctcattt tttctccatt caaacaaatg ataaactgca
     4081 accaagttgc catcaatttc atggacagtg ctctcggtaa catcctttaa agaactatca
     4141 agggctaatt tatagtaact agagagagga agtaaaattg tcgatttact gagatggtta
     4201 tcgtctatac gtgcaatcat acctaaatca actaaggttt tattccaggt gtttatagtt
     4261 ttagttgtca ctcctagaga ctctgctatg gtattgaccg aatgccagga atccccgcct
     4321 tcattctttg ccttaaaaca gtaatacaga tataaattaa tagctttgtt attcggtaaa
     4381 tatttttcaa gttctgttgg tagaataaag taagaatcct taatgttttt tctgaactgt
     4441 ctccagtctc tgtagttttg tttataaagt tgtgaaacgg tttttccacc tttagaaagt
     4501 cctgctatct taaccaatct tattgctcct ttcttgaatc tgtcatgatc atacagtatt
     4561 ttttacttgt agtccagcac cttaatatat tatcctatgt aattaatttc gtactagata
     4621 gtaattattt tttatttaat tctctagtca cttacaaata agttatataa actacgatta
     4681 ataaattatt acaaaaacta ttaagaaaac ttctacatac aactattaca aaactattaa
     4741 gaaactgaat actcctattt tttgttttta aggaaagttt tttctttttt gaatttctta
     4801 tttttttcta atataactaa gcaaaactgg ataatacgac acttattttc aaattttcac
     4861 aagactaata gtaaatatcc atttaataaa gtgatacaat gtgttgattt tacaaatcaa
     4921 cagaagaagt agggaaataa cttacctatg cttctttttt tgtacattta atcgattctt
     4981 ctttacaaaa acgaacgtat gtttgtataa tgtggaagaa tggagtgtta tttatgatgg
     5041 attattcaaa agagccagta aatgattact ttttgatcga tatgaaaagc ttttacgcaa
     5101 gtgtcgaatg tatagaaagg aatttagatc cattaacgac tgaattagtc gtcatgagtc
     5161 gagcggataa tacaggatca gggttgattt tagcttcttc accagctgca aagaagaagt
     5221 acggtatttc taatgtcagt cgaccacgag atctaccgca accttttcct aaaacgttac
     5281 atgtcgttcc accacgcatg aatctctata ttaagcgaaa tatgcaggta aacaatattt
     5341 tcagaaggta tgtagcagac gaagatttat tgatttactc gatcgatgaa tcgatcttaa
     5401 aagtgaccag atcaatgaat ctttttacga ctgaaggaac aagaagtcaa cggagaaaga
     5461 agctggctca aatgatccag gagaatatta aagaagagct aggattgctt gctacagtag
     5521 gtgtcggaga taatccctta ttagctaaac ttgctttaga caatgaagca aaacataatg
     5581 atggattcct tgctgaatgg acgtatcaaa atgttcctga taaagtatgg aatattcctg
     5641 aaatgacaga cctttggggt attggatctc gaatgaaaaa aagactcaac caaattggta
     5701 tcatgagtat taaagactta gctaattgga atccatacac tattaagagc catttaggtg
     5761 tgattggctt acagctgtat tttcatgcga acgggatcga tcgaacagat atagcgatcc
     5821 caccagaacc gacaaaggaa aaatcatatg gtaattcaca agtgttacca cgagattata
     5881 ccaggagaaa tgaaatcgaa ctggtggtaa aagaaatggc ggaacaagta gctattcgta
     5941 tcaggcaaca taactgtaaa acaggttgtg tccatttata cattggcacg tcgatcttag
     6001 aaacgagacc aggtttttca caccagatga agatccctat aacagataat acaaaggaat
     6061 tgcagaatta ctgtcttttc ttgtttgata agtattatga aggacaagaa gtaaggcacg
     6121 ttggaataac ctatagcaag cttgtgtaca ctgattcgct tcagctggat ttatttagtg
     6181 atccacaaaa gcaaattgac gaagaaaatt tagataaaat tattgacaag attcggcaaa
     6241 aatatggttt tacgtcgatt gtacatgctt cttctatgtt agaaggcgct cgtagtatta
     6301 ctagaagtac attggttggt ggccatgcag gcggcgcagg agggcttaaa aatgattgat
     6361 tataatgatc gtggacgttt aaagtgggca ggtttttatt tatctgatca tactgaaaaa
     6421 attgatgccg acaatgaaca acgagccaat caaaatttgg caaaagaaca aatgacgact
     6481 gaagaggttg cggaagtatt gaacgctgca gtcataaaaa atagatcagt atgtattcaa
     6541 aaagaagaac gaaacgctga aggatactat ccagaagata ttgttagcaa gatcttaggt
     6601 agtgatgagc tggggatcta cgttggaaaa aacaaagttc actacgacga aatacgtcat
     6661 atcgaatttt accaggataa taaatggggt cgattagaat gaacattatc cagcaatatg
     6721 agctaaagta tataaccttt gatcagctat cagaagagat ttggggttat ggccagcgtt
     6781 tgataaatga ggttggtgtt gaacgcttct ctttctatgt agaagctgca gcaggatacc
     6841 ataaatacga atactatatt ggctattaaa gtgcaataaa attatatttc ttttatgttt
     6901 tacattttgt atcaattctg ataaaattac ctataggtaa ttaaaaaata taaaaaaact
     6961 agttacaacc ttaggacgtt gtaactagct tgaagcatac tagagctaac taaaatagca
     7021 ctagaaagca atgttaaacc cgtccaacaa acttgattta acattgagac cagcttattc
     7081 agctaaatat agttgaataa gcttcttttg ttttaaaaaa acaaaaggtg tactacgaat
     7141 aacgcaagta aaagaaatac tattacaacc agtaggctac aagtaagtat tactaaacat
     7201 tgcgtagtta gaacctttgc tctattgtct aaagccacaa aattagagat cagctttatg
     7261 atgctaagag cgagctgcat ccatgcggac ataggttctt ttgacactat taattctcct
     7321 ttttaggata agggaaattg ctagtagttt tttcattagc accatccccc ttcatttgat
     7381 tgagtctagt gctgctgtga tagtttgctg tttaatatgc ttacattctt attataacat
     7441 aaatgaaaca aacacatggt tagaggtcgt atcaatcaaa atagtgtctc acaaacgatt
     7501 tattacttac tcctgctgac taacggactg ttcttcagta actgtaacta tatgtttgtt
     7561 aaaaccacca ttacctgtag ataaaaacca atatatttac tatactcact atattaaata
     7621 tatttagtat agtaaaaact agaaacaata aaatttgtga atgttgtata cccccaaaca
     7681 atacacatat tttgaaggat taggattaat aaagctaaaa atatagtaag tatactaaat
     7741 atatttacta tatctagtat acttactata ttttaatctt ttgatcgtct attatatata
     7801 atccgttcct cgtcgtttaa agtatcaaca taggcgtcca ttgcaagttt gactatttca
     7861 tacataggaa tatcttttgc ataactaaga tcccgaatgg tttttagtac gggaggatct
     7921 acttgaactg gttttctttc tttcgcagtg tactttcgtt cccctaactc gacattaata
     7981 tcatctttaa ttgaaatatc ttcagcacca attttcttct tatctttgtt cgttggtaat
     8041 aatgccattt agtttaatct cctttccaag aggtaggata tgattggcca ttgagtcagc
     8101 atatttaggt gtataatcaa atccttcaat atcaccatgt tgttcatagt attcaattct
     8161 ttcttctaat tctgtaaaga tgtctgcaaa aatagcccac catcttcgat ctacataatc
     8221 atttaattgg ataccattct caccatacat ttctaaccga tccgagcctt taacaatgct
     8281 tttaaaaatg tttgattcac catacttatc aattgttttt tgatagtttg cgtgttgaga
     8341 ggaacgtcgc actgagaaaa gaacaggcaa aattccaatg atttgaagat gagactcttc
     8401 aaaattcgtg acaatcggaa ctaaaacttt attaataaaa tcttctgttc cttccattgc
     8461 gtaccgtttt aattcttgca ttgcaataat ataatctgca gcagttaaga atgcacgaac
     8521 cacattatct gttgatggtg ggcagtcgat aaagatataa tcgaaatttt ttctcaattc
     8581 ttctaaaggt ttaatgaagg ccaatgatct cttacgacga tcaggatatt tttcggacaa
     8641 gtattcatta agttcttcag atccaggaga gccagccata atatataaat gtggacttac
     8701 ttgagtaata cctgaaaccc agtccccttt tttgattgct gcagacatgg atcgatcaaa
     8761 gctagtaatt tgatacgttg atccaatgtt ggaagtagta tttctttgtt ggtcataatc
     8821 aattagcaac acgtcttttt caaaaagttg actagaaaca atcgctaata aatcattgtc
     8881 tgtagtctta ccaatgccgc cttttctacc tgtaagcatt acaacttttc ctagtttatc
     8941 tgatgtttta aatgcagtcc gtaagttttc catagttccc tccaatttcc tatactaaat
     9001 atatttagta tacttcatat acttaatata ttcgatatat ctaatatact ccaaattgat
     9061 aagaattcag actttataag gaatatagtg gatatactaa atatatttgc tatattcagt
     9121 atatcagata tattcaaaat gtcaaaatat atttgtgcgt tttgcgttga caatttagag
     9181 tgaaaagagg taaacttaat tctatagaaa ccacagataa ttcactattt acaaagtagc
     9241 aaaagcagtg gtactcttta aacagaaaaa ttacataaaa aaaagagacg gaaataattg
     9301 attttagcag aatcaattat ttctgaatca catggttagg acatgtgttc acgctcgtct
     9361 caagaatatg taagtagcta ccaactactt atattaaaag ttgatcggat accttttccg
     9421 attgccttta ttctaccaaa aaaaggcgag caactcaaca gaagaacgtt tatttagtgt
     9481 acttaaatta aatattctta aacactgaag agagaacaca tactatggct gagattaaag
     9541 ctaaactgtg ttctcttttt gtttgagaaa ggacgttaca atcgatgttg agcgaaattt
     9601 attcagctat tcttaaaaac ggcttacgta catacaaata tcgaaacagc accatgaaac
     9661 ctgcaggtca tattgattcc agtaggagtg gtgctatctt tgcgtaccgt agcaagcaat
     9721 taatgaatgt tgggcgtggt atggtcatta cttcggaaga agctatttta gagaacgaaa
     9781 agaaactaac gcattggaca cctaatacct atcgctttgg tacttatgcg gatgattatc
     9841 gaacagtggt taaaggtcat tctgagaaaa acttaagtca aatcaacaca tttgtagttg
     9901 atatcgattc aaaagagaac catcaaggcg aaattatttt agcctgttta gatcaagtgg
     9961 gctacatgcc aacgctaatt ttagaatcag atcatggtta tcaagtttat tttgtactaa
    10021 agacaccagg ctatgtcaca aagaaaagca atttcaaggt gatcgatgta gcaaaaaaaa
    10081 tttcaaaaac aattcgtcta cagttggctg aaaaattgtc cggagtggat ctaggatgta
    10141 accacttcgg aattgctcga ttcccacaag aaaataatat tgtttttaaa gaaatgaact
    10201 atcagtattc ttttgctgac tggattcaat ggtcgatgaa gcttgaatca gatcaaaaaa
    10261 caaaagaaga tcgagaacga aaactaattg tctttcctga gaaaaaagaa attcgtcaag
    10321 tagatgaacc gtggttcgat atgttacttc ataaagcaaa catcgtcggc ggagaaggac
    10381 gtcttggtcg aaataatgtg attttcacgc tttctttagc ttattactct tcaggttatg
    10441 cattggatac ttgcgaatac aatatgttca cattcaacga acggttacag gaaccgctat
    10501 ctgaagcaga attagtaaag attgtacgta gtgcttattc tggtaattat caagcagcaa
    10561 gcagagaatt cattattgaa ttgtgccagc aatgggtttc accaacctta aaaaataatg
    10621 atctgttcat tcaacgacgt ggctggtgga aatttaaaaa gccacgagat caaagaaaat
    10681 atagtcataa aaatgaatgg aaagaagatc tattggctta tctaagcgaa aaaagtcttg
    10741 ctagtgagcc ttatttgaac ctgtcaaaaa aagaattggc ttcacaacta acgatgccca
    10801 agcgaacact tgataagatc ttaaatgagt tacgagagga gaataaagtc ttctacaagg
    10861 taacacgagg aagaaatggc ggaatgatca ttgcttcagt caaaacgttg ttcgcgaggg
    10921 ttattcaact aagtaaagaa aagagactag attattcaac aaggatcaca gaggtatttg
    10981 gactcaacga gagcttagta gaagagacat ttagacaatt atcaaccccc ttgaaccctc
    11041 ttaaagaagt gaatcttttt gaagtagata caggttgaaa aataaaaggt gcaaattgcc
    11101 ttatacaata tatctatgat acttctgtag gtgttgctcc ctttgcctag ctacgtgtag
    11161 gtggtatact tataactgcg tatgcagtct tatgtatcat ggaggaagtt gtatgtcgtt
    11221 aaaaaattat gtctattcac atcctgttaa tgtgtttatc attggtcgtt tgggattatc
    11281 tgtggaagtg ttctgtgagc tttatggttt taagcagggg actttgtctt cttgggttac
    11341 cagggaaaaa acagttgctt ctttgccgat tgagtttctt catgggttgt ccttagcttc
    11401 tggggagact atggatcagg tatatgattg tttgtgtgtg ttagagcagg agtatattga
    11461 gtataaaata gctaacgagt taagaaaaag gaagaagtat atccagtagt agtttttatt
    11521 tacttaaaaa attggttcat tgagcaacct atcgctgcta aagtagcaaa ggaaaacgtt
    11581 aaaggaaaga atttagggaa gaaatcgaaa tgaaatcgga cgactggatt gaacacacct
    11641 ggcttcctct gaaaagaaat agcaaacgaa agaaattttg ggtattgcaa ttatggccat
    11701 taggaaaact ttgtagttac ggggcacgac ttattcttga tttaaccgtt tactcgattg
    11761 gagtatttgg aacggcttat tacttgataa atgatcccaa taggattgca gcatcagaca
    11821 tttttacagt gctaatgacg ttgatttttg tcatgctatt gtctattttt actcaattag
    11881 tcatgcaatt taccaggcaa aaattaacag caggaaaact tttcaaaagc ctattcgatt
    11941 taattgttgt aaatgcaatt ctagcgactt taataaaaca aattgaacaa tctggaagaa
    12001 caacaaaagg agtgaaggat tttttattga cgtttattca ctttgtaaat ggacacatgt
    12061 atttgtttga agtgggtatt attctctttt ttgtcgggta tgtatccacg aaacttatta
    12121 aacgttcaat tgaaaaagaa attgaaattg acctgattcc gacacttctt ggttatgagt
    12181 acaatgttga ttttggaaga tatgacgaat tgatcaatac ggatatcgtt cacacgagta
    12241 tccatgaatc tactgttaag ggcatcagat ctattttaaa aaatggccag gaaatgaaag
    12301 caatagatcg aagaaaagag atctacaatt tttatgaagt cgaagcaagc ctacgatatg
    12361 gcatcggaaa attgtggtta gatggaagta atattcgtca aaacaaacca tacatttttt
    12421 ggaacagtag tgatttagaa cttccaatga aagataaata attatggaga atcgtttgaa
    12481 aatgattcct ctatacagga ttgtgcttat agttggcatg gagttaaaaa ccttaaagaa
    12541 ggagcagtta ttcaaagtga aagaacgtca taatcagtta ctatgtagta aaacgggtac
    12601 gatgaacatt gaataccgaa cagaatattt agaattaacg aatcaaactg attttttgtt
    12661 gattcgaaag caacaagagc aagaaaaaaa ttaatggcta cttatagcca attgattgat
    12721 gaatgggaac aattcaagga atctaaaatt ccagaacgtc tctaaaagcc tttatttgta
    12781 aagagcataa ggaaacgtgg gaacactttt taaaaaaagt gttccaatag gctgtgccta
    12841 ttacgtttct caaaaataaa tgtgggaaca aaatatttaa aaataggata gtgaaaggat
    12901 agtgaaggat agtaaaagga gggtagtagg atagcaaaaa ggataggctc cttttcgcta
    12961 tcctttttaa attggaggaa ttaatatgga agtaagaata agaaatgtgg atgagaaaat
    13021 cgtaagagaa attgatcgaa gatgtgacga acggttctgt tgcaaagttt taaatctact
    13081 atcaaataag gtagaataat agaaaaagat agcaggagga atgacgatga atccttttaa
    13141 aggaaagcaa tttcagcagg atgtgattat tgtagccgtg ggctactatc ttcgttataa
    13201 ccttagctat cgtgaagttc aagaaatctt atatgatcgt ggcattaacg tttctcatac
    13261 gacgatttat cgttgggtgc aagaatatgg caaactactc tatcaaattt ggaaaaagaa
    13321 aaataaaaaa tccttttatt catggaaaat ggatgaaacg tacatcaaaa ttaaaggaaa
    13381 atggcattat ttgtatcgag ccatcgatgc agatggttta accttggata tttggttacg
    13441 taaaaaacgg gacacacaag cagcctatgc ttttcttaag cggttagtga agcagtttga
    13501 tgaaccgaag gttgtagtca cagataaagc cccctctatt acaagtgcct ttaagaaact
    13561 aaaagaatac ggcttttatc aagggacaga acatcgtacc attaaatacc tgaataattt
    13621 gattgaacaa gaccatcgtc cagtaaagag acgcaataaa ttctatcgaa gtttacgcac
    13681 tgcctctacc acgattaaag gcatggaagc cattcgagga ttatataaga aaacccgaaa
    13741 agaaggcact ctcttcgggt tttcggtctg tactgaaatc aaggtattat tgggaatccc
    13801 agcttaaatc atagataccg taagggattt tattctttat ttaaaacttt gcaacagaac
    13861 cgataatttc tccaggatca atatttagtt gagttgctac ataactcaat acattttggg
    13921 gaatattggt aagatctaat ataaaagttc ctaaaaaacg tagtgagact aactgtagtg
    13981 caaaacctaa tctagtagct ggtcgtcgta tagtctccat caattctaaa tctttttcat
    14041 gcaaataaaa aaattggttt aattgttctg tactaggttc tcctaaataa atgccaaatg
    14101 cttttttgtt acttttgatt tcatccattt aaaccctcca tgaagtaaat tttaagtcta
    14161 cataaaattt atttttaaaa atgctatgat agcagtaaaa ctacaagtaa attttacatg
    14221 taaattatat cacttttaaa aaggagtttt ttatgggaaa aattggctat attcgagtat
    14281 cttcacaaga tcaaaatttg gatcgacaat tggcaatgat ggaaggactt aacattgata
    14341 aattattcca agaaaaagcc agtggtaaag atactgagcg tcctgagttt caaaaattac
    14401 taaattatat ccgtgaaggt gattgcgtca tcgttacatc actagatcgt ttaggaagag
    14461 attatgaaga tataaaaaat acagttgctt ttatgaaaca gaaaaaagta gcgttaaaaa
    14521 tattagatgc acagttttta gattttaata ctggaaatga actcctggat accgctatgt
    14581 tcgatatgtt tttatcactg ctaagttata ttgcacaaaa cgagcgtgag aaaattcgtg
    14641 aacgtcagcg gcaaggagta ttattggctc aaaaagccgg ccgatataag ggacgaccaa
    14701 tcgagtattc tattaactca acagatccgc aaaaacgctt agtttttaaa accgtggtgg
    14761 acatgttaaa gcaaggcatt ccagttgcag agattgcaaa agaaaacggg atctctcgac
    14821 caactattta taaaataaag aaagcgaatg atttgtagaa atatactaca ttcattcgct
    14881 tttctaccgc actatttcgt ttctatgttc catgtacccc gatatagggt ccattataaa
    14941 tcacactatc agagttcgta ccatatctat ctccttcttt ttcaacaact tcctgttttt
    15001 gaggaaaaaa tgctgtatta attagcatag aagtgaaata tgggattggc gtactcaaat
    15061 taataaccaa agtattctta tccttagcat aaactcccaa cttatctggt ttcatagttc
    15121 ctgagattat ttctttacca tttttaatag attcaaaaaa accaatattt ggtgaatctt
    15181 gattacttaa cgttcttttc cacgaataaa catagtcatc tgcaacaaca ggcgtaccat
    15241 tactccacat tgcatccttt ctcaatcgaa taacgtactt aagtccatcc ttagagattt
    15301 ctggaaggcc attagctcct ccaggtacaa tttcaccttt agcattaagt ttatataatc
    15361 cttccattac gttatttaaa acaagttggc ttgtagggtc gatagctaac ttcggatcta
    15421 agctttgtac tgtagtagaa acagcaaaag tataagcttt ggtttctttt gctgtttctt
    15481 gagacttttc cccacaacca gtaataatta ttcctaacat aagaattgtt aaattctttc
    15541 cccaagttct tttcaaaaaa acacccctat tcaatttctt atctgattgt tctagcaaca
    15601 cttagcttaa ttatactgta aaaaaaacgg gtcttcggaa tatatagtgg aattactttc
    15661 ttaatagttt aaaaacaact ggtgtttaaa tcggattttc tggtgggatg ttaggataat
    15721 caatagtatt atataaaagt atcaatcaca tacgagtgat actttgggaa aaaaataaaa
    15781 tagtccaatt tacttgaacg tgtactatgg tacacggttt ataatattca tggggtgaaa
    15841 taagatgatt tatcgcatta gtgagtttgc agataaatgt ggagttaata aagaaacgat
    15901 cagatattac gagcgaaaaa atttattaca agaacctcac cgaacggaag ctggttatcg
    15961 gatatattca tatgatgacg ttaagcgtgt tgggtttatt aaacgaatac aggaacttgg
    16021 tttttcttta agcgagattt ataaattact tggtgttgta gataaagatg aagttcgttg
    16081 tcaagatatg ttcgaatttg tttctaaaaa acaaaaggaa gtgcaaaaac aaatagagga
    16141 tttaaaacga attgaaacta tgttagacga cttaaaacaa cgatgtccag atgaaaagca
    16201 attacattcg tgtccaataa tagaaacatt aacatgagag attaattaac gaaaggagct
    16261 tttttatgaa taaatttaag gtaaacattt caggaatgac ttgtacgggt tgtgaaaaac
    16321 acgtagaatc agcacttgaa aagatgggtg ctaaaaatat tgagtctagt tatcgtcgtg
    16381 gtgaagcagt atttgaactg cccgatgata ttgaggttga aagtgcaata aaggcgattg
    16441 ctgacgcaaa ctatcacccg ggcgaagcag aagaatttca atcggaacaa aagacgaatt
    16501 tattgaaaaa atatcggcta aacgttgaag gaatgacctg cactggttgt gaagaacata
    16561 ttgcggttgc tcttgaaaat gcaggtgcaa aagggattga agtagacttt cgtcgcggag
    16621 aagcactgtt tgaactaccg tatgatgtag acattgatat cgcgaaaaca gcgattactg
    16681 acgcacaata tcaaccgggc gaagcagaag aaatacaagt gcaatcggaa aaaaggacag
    16741 atgtaagttt aaatgatgaa ggtaactatg attatgatta catcatcatc ggttctggtg
    16801 gagctgcctt ttcatctgcc attgaagccg ttactttgaa cgcaaaagtg gctatgattg
    16861 agcgtggaac ggtgggtgga acttgcgtta atgtcggatg cgttccttct aagaccttat
    16921 taagagcagg ggaaatcaat catctagcaa aaaataatcc atttgtggga ttacacactt
    16981 cggcttcaaa tgttgattta gcgccattag taaaacaaaa gaatgattta gtaaccgaga
    17041 tgcgaaatga aaaatatgtg aatttaattg atgattatgg ttttgaatta ataaaaggtg
    17101 aagcaaaatt cgtaaatgaa aatacagttg aagtaaatgg caatcaaatc acagccaaaa
    17161 gatttttaat agctacaggt gcttcttcaa ctgcacctaa tattcccgga ttagatgaag
    17221 tagattattt aacaagcact agcttattgg aattaaagaa ggttccaaat cgtcttaccg
    17281 taattggttc aggatatatc ggcatggaat taggacaact atttcataac ctcgggtcag
    17341 aagtcacttt gattcaaaga agcgagcgtc tattaaaaga atacgatcct gaaatttcag
    17401 aagccattac taaggcctta acagaacagg gaattaattt agtaacaggt gcaacctatg
    17461 aacgagttga gcaagatgga gacattaaaa aagttcatgt tgagataaat ggtaaaaagc
    17521 gaattattga agcagaacaa ttgctaattg ccactggaag aaaaccaaat acagaatcat
    17581 taaacttaca tgcagcaggc gttgaagttg gttcccgtgg tgaaattgtc attgatgatt
    17641 atcttaaaac gaccaattcc cgaatttatt cagctggaga tgtcactctc ggtccccaat
    17701 ttgtttatgt agctgcttat gaaggtggac ttgctgctcg taatgcaatc ggaggactaa
    17761 atcaaaaggt caatttagaa gtggttccag gcgttacgtt tacttctcca tcgattgcaa
    17821 cggttggttt aacggagcaa caggcaaaag aaaaaggata tgaagtgaaa acatcggtat
    17881 tgccgttgga tgctgttcca agagcgctcg ttaatcggga aacaacaggt gttttcaaat
    17941 tagtggcaga cgcgaaaaca ttgaaagtgt taggggcgca tgtagtggca gaaaacgcag
    18001 gagacgtaat ttatgcagca acattagctg tgaaattcgg tttaactgtt ggagatctga
    18061 gagaaacgat ggctccatat ctaacaatgg cagaaggatt gaagctggct gtcctaactt
    18121 ttgataaaga tgtttcgaaa ttatcttgct gtgcaggcta agggaacttt tttacaactc
    18181 cctattcaag tgaaccagct aatgctttaa gggattttct aagtgcattt gtggtcacaa
    18241 aaataattta acactgatga tttcgacatc aaatctataa ttgatacctt aacaccgcag
    18301 agtaataaag gatgaataat atgtcagact tattatccct accagacatt aaaacaatag
    18361 agccgccaca agaaaatgaa accgatatga tgtttaaagt tgaagcagtc ggaccacctg
    18421 aacgttgtcc tgaatgtggt tttgacaagt tgtacaaaca cagttcaaga aatcaactaa
    18481 ttatggattt gcccattcgt ttaaagcgag tgggcttaca attgaaccgt agacgataca
    18541 agtgtcgtga atgcggatct accttctggg aacgcctaat atctgtagat gagaagcgta
    18601 gtatgaccaa aaggctttta aagtccattc aagagcaatc catgtctaag acctttgtag
    18661 aagtcgcaga aagcgttggt gttgacgaga aaaccattag gaacgttttt aaggactatg
    18721 tggcactcaa agaacgtgaa taccagtttg aaactcctaa gtggcttggg atagacgaga
    18781 tacatattat ccgtagacct cggcttgtat tgactaatat tgaacgcagg actatttatg
    18841 acatcaagcc taaccgtaac aaggaaacag tcatccaacg tctttcagaa atcagtgaca
    18901 ggacttacat tgagtacgtc acaatggata tgtggaagcc ctacaaagac gcagtgaacc
    18961 ctatccttcc acacgctaaa gttgtcgtag ataagtttca tgtagttaga atggctaatc
    19021 aagccttaga taacgtcagg aagtctttga aagcccatat gagccaaaaa gaaagacgta
    19081 cccttatgcg tgaaaggttt atccttctaa agcgtaaaca cgatttaaat gaacgtgaat
    19141 cattcctctt agatacttgg ttaggtaatc ttcctgcttt aaaagaagcc tatgaactca
    19201 aagaagagtt ttactggata tgggatactc ctgatccaga tgaaggtcat cttcgttata
    19261 gtcaatggag acaccgttgt atgtccagca actctaaaga cgcatataaa gacctcgtga
    19321 gagccgtaga caactggcat gtcgaaatat tcaactactt tgataaaagg ctcactaatg
    19381 cttatacgga gtcaattaac agcattatta ggcaggtaga gcgaatgggt agaggttact
    19441 cgtttgatgc cttacgagcc aaaatccttt tcaatgagaa gctccataaa aagcgtaagc
    19501 cacgatttaa ttcaagtgct ttcaataaag ctatgttata cgatactttc aattggtatg
    19561 aagtgaatga tcacgacatt acagacaact ttggtgtcga tttttccaca cctattaaga
    19621 atttggagaa gggtgattta taagcccttt tccaccataa aatccgaata cccaaaaaaa
    19681 caaaaatata cagaattagg ataataacta acaaaaacga aaacaagtat aaaagaaata
    19741 taatgtatag gcacttgaca tgttttattt tatcctgtat tccacaaatt taattgctta
    19801 taatgatcta ctctttgact gtatttatcc ggttctctga agattcttac taacatatcg
    19861 gcttctttaa aaaatgtctt aatgccctgt ttgtacgcag attttacctg ttgcttcact
    19921 tgaatgaccg tacgaattaa cgctttacga gtggcaacta ctagtccccc attccgtcca
    19981 gcttttattt gtacaaataa tttaccttcg gccatcaatt cttttaatgc acggtcaaga
    20041 gaacgtttag gaattgattg tccgttgaaa gtaatcgctg cttgcaaatc tgttttcttc
    20101 agtctgactt caggtctgta tctataacat tgggtttcaa ggtaagctaa aatatcttct
    20161 ttccattcgg aaaggtgaga tttctttctt ttatgacgtt ccttcttaaa tttgtaccaa
    20221 gtatttcttt gttgtgtaaa cattttttcc tcagacagcg attctaagcc ccaatttgac
    20281 actaactcct gtacataagt cttacttgca cctctatact tcccagagta agcacttttt
    20341 acaattctta ctcgttctct atcttttaga ggacgttcta aagaactgtt aaaaagatcc
    20401 atctcattta gacagtcttc taagtcaact cctgatgcat aattggccaa agataaagtg
    20461 aaaatcacat tattccggcc cataatccct ttagcgccta caatttttgg attactaatt
    20521 aattgtcgat accacatttc gttcacttgt ttatatttat ttttaacaag tgaaagtagc
    20581 ggttttttat atgttttcgc tggctcatat ttcattgacc attggattaa ttgctgtata
    20641 tcatgtgtta aagctggata ataatagaca atgttgtcag ttctagggat acgtgctatc
    20701 ccaaaatgat tgcaacctaa atcgactgaa ggcaattctt cagcaaatgc ttttcttaag
    20761 ttctcagata ctcgtttggc cacttcgatt gactgataat tatttttgga cgaaatatac
    20821 caggcatttt caagaataaa gtatgcttgg aagccccctg gtgtttccaa aataagggtt
    20881 ggcattaatt ccagatcgat tgctgcatcg agaatcattt gagaatctaa tttttcgcct
    20941 gttaagcgat caaaatcgat tacaaaagta ttgatttgtt gcaagttgcg ttcgttgtgc
    21001 ccttttacaa ttattctttt ttcatctgca tatgcaccat agctgtaaac gttaggtgtc
    21061 caatgagtaa atttatcttc attttcagct aagccttctt gagaagtaag aacgattcca
    21121 cgagattccg tcattaactt cttggatcta aacccaaaaa tagcaccttt ttttccttca
    21181 gctttatagc cgattggttt aattttgctg tttaaacact tgtattcacg aataccactt
    21241 tttaaaataa ctgaaatcac gtcagaaact ttcatcttat caccacccat tctatattta
    21301 aaaaaaggag aactgcaggc attctacagc tctcctttaa accttatttg cagctaaaat
    21361 atagctcaaa atcttgattt ttaaggtccc aaatgatata attaaaaaga ctaagagagc
    21421 tgcaactctc tgtaatctaa aactataatg ggacgaaaga gaatcatgaa atgctgtgta
    21481 cattttgatt ctgtaattta gttgatcggc aaatcaacta agttaccgtc tctatttttt
    21541 tgtctataat tcaattagta aatgtatctt ttttctattc attcaaattc ttctttagaa
    21601 tacatgtcac tacaactttt gtaaagtaaa aattttctct caaataatca ttcttaattt
    21661 atttttgtat ccttttatct ttgtatcctt ttatcttttt atctttttat ctttttatcc
    21721 tttaatttta ttgttgtatc tttttatctt tgtatccttt tatcttttta tctttgtatc
    21781 cttatttaga agtctattta ataacttttc ttataaaatg ctatctgatt aaataagtat
    21841 gttttaagat aattagaaaa aagatacatt tatctattta caattaattc tatttgtatt
    21901 actatttaaa tatagaaaaa agatacaaag atacatttat cttttattac attttgatta
    21961 caaggaagga gtatattgat ggctaataca attatatttg gacaacaaaa gggcggggta
    22021 ggaaaaacaa ctgacacttg catgataacg ttggtagctg cgatgctaat gaaaaagcgt
    22081 actattttaa ttgatattga tttgcaagca aatgcaacaa attttatgac aaaaacattt
    22141 ggggtagaaa cggtacctca gactttgatg tctgctcttg aaaatggcga tctacgtcct
    22201 gctatcgtaa accttaagga aaacttagat ttaattcccg ctggttatga tatgcgtcta
    22261 tacactgaat tcttaacaga aaattttgat aatacaatag atagaacttt ttatcttaaa
    22321 aaccttattg aagaaattaa agacgattat gattatattt ttattgacat cccaccttca
    22381 accgatttaa aggtagataa tgctatggtt gcatgtgatt acttggttgt agtacaagaa
    22441 acacaacaat tttcttttga gggaagtcaa cggctaattt ttgattatat acaaacctta
    22501 gttgacgatt ttggctcaga cgttccaatt caaattgcag gcattttacc tgcattgtta
    22561 caacaaaaac gcccaatgca ccaaaaatta gttgaggaaa caatagacac atttggaaga
    22621 gacaatgttt ttaacactat tattcaaaat catgcacgtt tagagtggta tccacggatt
    22681 ggatttcaat ttcaagacta tcatgataaa aaaatgattg ctctttttgc agatattttc
    22741 tgtgaattag aagaacgcat cactctttat aaaagtaatg gtgatattca agattatttt
    22801 tatactccga gatatatatt agacggaaaa ttaacttccc tgggaaagga gattagtcta
    22861 aatgtctagt ttgataaatc gtaaaatccc acaaggggca acagcaaata aagaagcaga
    22921 tacaaaacga aaagttacta ttcaaaaaaa atcgagtaaa aagatattag cttcagaaag
    22981 aaaaaacatc aaagtgtccc cctctacttt tgacttaatt aaaaccatat caacaatgaa
    23041 aagctacaaa aattatgaat ttattgataa agctgtagaa agctatatac aaaataattt
    23101 aacagaacgt gaacaacgta tcctcaaaaa tttaatctca aaataaataa aaaaggataa
    23161 aaagatacat gtatcttttt atcctttttt atttattgat ttctttttat caatgcagat
    23221 tttaccattt ttatcaagta gaggcgtaat tcctccttta ggagtttcta aataattcac
    23281 accagtaaca gtatcaacta caattttata gcctaataga gttaaagatt cactttcttt
    23341 ttcaacaaaa cgtttgtctt taaatacatg ttccttacat ttatgtctgt ctaatggtac
    23401 gttatctgat tgttctatca actcactatt tgaattatcc ccggcaacca tcatgcctaa
    23461 atttttatca taataaatat attctccacc tagtattaag gttaatggca taaaaatctt
    23521 cctttcttta attttcttac cgtccttttt ctcttttttt aacggctttc gttacttacc
    23581 tttttgttca ttttctacgc acaatcaatc gattaaacag attgcctctt attccaataa
    23641 gtaaatttca agtgcaaatc atcctatttt taaataggat ctgttgtcaa ctttttctta
    23701 attctatcaa aaaacggaag attttgcttg caaaccaatt cccttttact aaattaaaat
    23761 aggtttttat ttagtatgaa acagaaacca acattgaagt aaatcttatt tgtttattct
    23821 ttaattattg taattgctac atattctcct tgtttctgtt tgtatcggcg atggcattta
    23881 ggacagtaaa agtaattttt ttgataaaca ctttttgcta attccccaca gtcacactcc
    23941 acgtgaaaag caatatttcg attaaaacta gttatttcaa tgccccaacg atcataagat
    24001 tttcgcttca taaaaatttt cctccttgta aattttacta acgattataa ataccgttgc
    24061 cattctttca actgttgact aattaacgca taaaattcga cttctgataa aatggtaatc
    24121 tcatgaccta acgcaatcaa gtcccgcgcg gtttgttcct tttttgtata gagagaatca
    24181 tcaaacaacg acttagaata ctgaccacaa accaggaaat ttgtttttga agtaacactt
    24241 gattgacaat ggccgtttaa agagtgaacc aaaccgatgg cttgggttcg tgtcatttgc
    24301 tgcagcgttc cagtaaaaac gaccctttga ttcgttaagt ccattttcaa actctccctt
    24361 cccgtctaat agctgttata tctatcaaga aaagtggtgc aaggtatgtt catattcttt
    24421 cacccgtcga taaaaggtat ttcgtttcat gcccaattga tccatagcat agactgcagt
    24481 tatctttcct gctttccagt cagaatagat cgcaggaaat tcaggaggta aagcaatttt
    24541 ctttctgccg aattttacac ccttttgttt cgcagcttct acgccttctc tttgccggct
    24601 attaattcgt ttccgctcgt cttcggccat atagctgagt aattgcagaa ttaagtcaga
    24661 gataagcgtc tctaacccat ctagttgctt gtaactagca gtatctaaca gaggcatgtc
    24721 taacacagaa atatcaatct gcttttcctt agttaattct cgccattctt ctaaaatcat
    24781 ttgtttattt ctgcctagtc tatctaatga ttgtagatag agtaaatctc cttttcgaaa
    24841 catccgtttc attaattgat attcagggcg tttaaaatct ttgccgctgg ctttttctac
    24901 aaatatatat tcttcaggga ttcctaattc cttcgcggaa atcagttgtc gttcgatcga
    24961 ttgatcataa ctactgaccc ggatataaaa aaattttctc atcgttttta tctacccttt
    25021 tttcactaaa attgtttcaa aacaatcaga ttaaatcaga aacgtttcaa attgtattat
    25081 gtggttatta tgccatacat aaacaaagaa aatcaaggca tgtcaaaaag tatacttttt
    25141 gaaacagtaa gtttacactc ccgcatgatt atatttattc cgctaaaata cataaaaatg
    25201 gcaggcctta acggtctgcc attaaataaa ctagttatcc agtttttctt ttatgtcttc
    25261 catggtatat tttatttttc acatcagaat ttgacttctt taacttttac aattttttta
    25321 acactattat tctattacaa cactatatat ttctaattta gggttaaaaa taaatctttt
    25381 tgatactttt gcctttacaa tataattgta ttctttcttt ttttctttga agtcgcttga
    25441 ttcaactgta acttcaaacc acatttcatt tggagactct tttaattttt ttacttgaaa
    25501 tgaattatct cttggatcat aaggtggtac tctttcaaac tcaggaagtt ttctctgtat
    25561 ttgttcttca ggagtattcg caaagtaatc tactatcttg acagttatta aaagtactac
    25621 tattcccaaa actataacaa acataaagat aattccacat ccagaattat ttttattatt
    25681 ttgagtcaga ttattccatt ctatttcttc cataatcatc atgtcctttt acaattcata
    25741 tacttatttt atcgtatata tttaaaaagg aaaaggacac tgtttaaata gtaaacgatt
    25801 cttaattaag tttacttcta ttttcttgaa attgaataat tttttcagaa aatccatttg
    25861 caactttccc ctcatctcca ataaaatcaa gataagtaaa atctgtccca agtgaattat
    25921 taactatttt atcaatgaaa aatgaaatta tccctacacc taagatatca actgtttcgt
    25981 cattttctaa taaactattt gttactgaag cgattttatc tgaagaacca aatctgttct
    26041 taacaaattg attaaatcta tcaatagcac ccttatcaca atagtacgtt tttaaagccg
    26101 ataaagctgt tgaatcagaa tttctttttg ctaaggtata aacatttacc gcgtcaacat
    26161 cttggtataa atcttctaga ctaaatgttc cacctgcagc cgtacctact aatgcaaata
    26221 caccttgctc catttgtatt cctaatttct taacttcacc ccagcaagtc attaaatctc
    26281 ctaaccaacc tgcaaagtca gaaacactat cattgattgt gtcggctaga aacatctgtg
    26341 attgtaacgt cacaattaag tgaggcaaac ctattattga accagtatta ggatctataa
    26401 aataattata caggccctcg ctattagtta atttattcct atattcatca taaatttttc
    26461 tatcatgctc tgttacagga gaagaaatga tgtcccatga caaaccagaa taatttacat
    26521 atctataaaa tgtcaaatga gggttccaag gattatcaag accagcttgt gatagatatt
    26581 gatacgcacg taccatctga tttataacct tctgattgta tttggcaatg taattatcat
    26641 tattagtatc atttgataac tcattaaatc cgctatctct acccgatgta gcgattaaat
    26701 cgataccaac agctccgttg ccacttccta tggtaaattc aacaaattga tcaaaagacc
    26761 attgtctagg cataggaaaa cctaaattcc cactataacc agtcgacata tctgaaacaa
    26821 atgcaaacga agcatacccg ttattgatta tttgagaaca aacatttctt gttccgtaaa
    26881 cacccgtttg atacccgcta tatgacatta cagcagatac ccccttaaaa tattctccag
    26941 catatgcaag aatttcttcc cctaacatgt ctagatcaac agcaaaataa ataactgttg
    27001 ttaatggtat atttagattt tttgctgcat ctatagcctt cttaccatct gataagccac
    27061 gatcataagt aaaataagct aatgctgcac ctccatcttg atagatagga aacacagata
    27121 aatttttaga aaaaatatta ttcaattcct ctgtagttag atacttattt cgttcatctt
    27181 ttccaattcc aacagtacca gtaagatatc taccaactat ttttatatca ttatcaacca
    27241 atgtttggat ttgagatcta gttaattgcg tagaagtatc tgcgccatct gcagatcttc
    27301 taatatctcc agcgctagac aaaagtcctt ttattacaac aacatctgct atttcagtat
    27361 attcaggcaa taccataaat tttcggaatg ccagtacttc taaacccata tatttagtga
    27421 aaataccatc gaatgtaccg tcttcaaaat aaccattaac atataatcca tattgaatta
    27481 ttcttacata gtttcccgag ttaccttcag acacaggata agttttacta gttgtcccat
    27541 taccataaga ccctgttgct tcactgggag aatatcctag ttcagcttgt aatgcaaaaa
    27601 ttaatgcttg atttgaattt ctttgataaa taccatcaca aggcattatt cccgtgtatt
    27661 ctaaataatt tacatttaac cattgctgca tttttctaat tttactatct ccgccgggaa
    27721 caagaacaaa agcactcata tcaaataacg ctttggccca tttcgcatcc aaaactccag
    27781 ttacagcgct tccattaaac cctgcatcag tctgcaactc ttttacagca gtatctaaat
    27841 atggagtata taccccatcg aagccacctg gattaatccc cttacaccaa aaggcacctt
    27901 gaataagaaa tacaatattt ttaggtagat ttttgcccca tttaggagta acctgattat
    27961 cgtacatttt ttcagtggta ggtccaaaat tagctactag attagtaata ccaagttcta
    28021 cttgtagtcc ttcaataagt ccatagattg taggccaccc tgttcgccca ttttctggaa
    28081 ccttatcaaa ccctgtaaca ttactgtatt tcttgtttag ccatttctga gtacttaaaa
    28141 ccatctcatc cataaaaatc ccctgctttc ttgccgaaca tacgttcgtt tatgtgttga
    28201 ttaggttctg ttgcaaagtt ttaaatctac tatcaaataa ggtagaataa tagaaaaaga
    28261 tagcaggagg aatgacgatg aatcctttta aaggaaagca atttcagcag gatgtgatta
    28321 ttgtagccgt gggctactat cttcgttata accttagcta tcgtgaagtt caagaaatct
    28381 tatatgatcg tggcattaac gtttctcata cgacgattta tcgttgggtg caagaatatg
    28441 gcaaactact ctatcaaatt tggaaaaaga aaaataaaaa atccttttat tcatggaaaa
    28501 tggatgaaac gtacatcaaa attaaaggaa aatggcatta tttgtatcga gccatcgatg
    28561 cagatggttt aaccttggat atttggttac gtaaaaaacg ggacacacaa gcagcctatg
    28621 cttttcttaa gcggttagtg aagcagtttg atgaaccgaa ggttgtagtc acagataaag
    28681 ccccctctat tacaagtgcc tttaagaaac taaaagaata cggcttttat caagggacag
    28741 aacatcgtac cattaaatac ctgaataatt tgattgaaca agaccatcgt ccagtaaaga
    28801 gacgcaataa attctatcga agtttacgca ctgcctctac cacgattaaa ggcatggaag
    28861 ccattcgagg attatataag aaaacccgaa aagaaggcac tctcttcggg ttttcggtct
    28921 gtactgaaat caaggtatta ttgggaatcc cagcttaaat catagatacc gtaagggatt
    28981 ttattcttta tttaaaactt tgcaacagaa cc
//
