LOCUS       NZ_CP016862            27067 bp    DNA     circular CON 17-JUN-2024
DEFINITION  Staphylococcus aureus strain 1625.C01 plasmid p1625.C01, complete
            sequence.
ACCESSION   NZ_CP016862
VERSION     NZ_CP016862.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN04964640
            Assembly: GCF_001717725.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 27067)
  AUTHORS   LaBreck,P.T., Rice,G.K., Paskey,A.C., Elassal,E.M., Cer,R.Z.,
            Law,N.N., Schlett,C.D., Bennett,J.W., Millar,E.V., Ellis,M.W.,
            Hamilton,T., Bishop-Lilly,K.A. and Merrell,D.S.
  TITLE     Conjugative Transfer of a Novel Staphylococcal Plasmid Encoding the
            Biocide Resistance Gene, qacA
  JOURNAL   Front Microbiol 9, 2664 (2018)
   PUBMED   30510541
  REMARK    Erratum:[Front Microbiol. 2020 May 14;11:877. doi:
            10.3389/fmicb.2020.00877. PMID: 32477301] Publication Status:
            Online-Only
REFERENCE   2  (bases 1 to 27067)
  AUTHORS   LaBreck,P.T., Rice,G.K., Paskey,A.C., Elassal,E.M., Cer,R.Z.,
            Law,N., Schlett,C.D., Bennett,J.W., Millar,E.V., Ellis,M.W.,
            Hamilton,T., Bishop-Lilly,K.A. and Merrell,D.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-DEC-2017) Microbiology and Immunology, Uniformed
            Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
  REMARK    Nucleotide sequence updated by submitter
REFERENCE   3  (bases 1 to 27067)
  AUTHORS   LaBreck,P.T., Schlett,C.D., Elassal,E.M., Lanier,J.B., Law,N.,
            Bennett,J.W., Millar,E.V., Ellis,M.W. and Merrell,D.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2016) Department of Microbiology and Immunology,
            Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD
            20814, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera v. 8.2
            Genome Coverage                   :: 23.66x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001717725.1-RS_2024_06_17
            Annotation Date                   :: 06/17/2024 00:27:59
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,924
            CDSs (total)                      :: 2,842
            Genes (coding)                    :: 2,756
            CDSs (with protein)               :: 2,756
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 86
            CDSs (without protein)            :: 86
            Pseudo Genes (ambiguous residues) :: 0 of 86
            Pseudo Genes (frameshifted)       :: 46 of 86
            Pseudo Genes (incomplete)         :: 42 of 86
            Pseudo Genes (internal stop)      :: 21 of 86
            Pseudo Genes (multiple problems)  :: 22 of 86
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP016862.2.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..27067
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="1625.C01"
                     /isolation_source="Purulent absess from military trainee"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="p1625.C01"
                     /geo_loc_name="USA: Ft. Benning, Georgia"
                     /lat_lon="32.3913 N 84.8229 W"
                     /collection_date="2011-03-11"
                     /collected_by="Uniformed Services University"
     gene            join(26690..27067,1..12)
                     /locus_tag="A7Q05_RS00005"
                     /old_locus_tag="A7Q05_05195"
     CDS             join(26690..27067,1..12)
                     /locus_tag="A7Q05_RS00005"
                     /old_locus_tag="A7Q05_05195"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]; GO:0006355 - regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="WP_001186978.1"
                     /translation="MQQNQPFNMTVTITKIQALLRRTYDFTTQVNNLTVDDCELLLDAA
                     KLKFNEETIDLTHTELQIMHSLFQNKGKFVSRNALIEKCWESEHFIDDNTLAVNITRLR
                     KKLQKLGLTDFIETKKNVGYRVGDV"
                     /name="response regulator transcription factor"
     gene            9..890
                     /locus_tag="A7Q05_RS00010"
                     /old_locus_tag="A7Q05_2951"
                     /pseudo=""
     CDS             9..890
                     /locus_tag="A7Q05_RS00010"
                     /old_locus_tag="A7Q05_2951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015581923.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0000155 - phosphorelay sensor kinase activity [Evidence
                     IEA]; GO:0004673 - protein histidine kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /name="sensor histidine kinase"
     gene            1006..1935
                     /locus_tag="A7Q05_RS00015"
                     /old_locus_tag="A7Q05_2952"
     CDS             1006..1935
                     /locus_tag="A7Q05_RS00015"
                     /old_locus_tag="A7Q05_2952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074567.1"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA];
                     GO:0042626 - ATPase-coupled transmembrane transporter
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000793446.1"
                     /translation="MKNLNNIIEINNLTKQYGSQIAVNNLSITVESGQIYGFLGRNGAG
                     KTTTIRMLLGLIKPTKGNIKIFEKEFESNKTEILKNIGAMVETPGFYSNLTAKENLTIN
                     AKILGIQKENAIEEVLEIVGLASEKVKLFKNYSLGMKQRLGIARALLHNPELLILDEPT
                     NGLDPIGIKEIRKLIKDLAQSRNITILISSHILSEIEQLVDKVGIIHNGVLLEEIMYED
                     LKKKNRQFISISVSDEEKVACLLETNFGIYDYKIKENGEFKIYSHIDRQQEINRLLVLN
                     NIDVFQMRVIEDNLETYFEDLVGGGTIG"
                     /name="ABC transporter ATP-binding protein"
     gene            1928..2665
                     /locus_tag="A7Q05_RS00020"
                     /old_locus_tag="A7Q05_2954"
     CDS             1928..2665
                     /locus_tag="A7Q05_RS00020"
                     /old_locus_tag="A7Q05_2954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000369394.1"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="WP_000369394.1"
                     /translation="MDNLLRTEFIKLKRSYMFLISILGTCVAPFMVVVASFISMRTKVP
                     TPNIVFKQLFEEVSLYHMLIIGPPLYGVIIAYLFGREYIEDTLKNLLIIPISRESFLVS
                     KIILLFLWIQTLSVIAWLLTLMLGMLLHFQGLSQSLIIDSFFTFVIGGVLLWILSPPII
                     ILSIYFKNYVPTIVLTIIITLINLMTANSEHRGLFPWAAVGDISRGTLPNTYPFLLSLI
                     IIIVTSIFSVIILFSYFKKTDIS"
                     /name="ABC transporter permease"
     gene            2679..>2855
                     /locus_tag="A7Q05_RS00025"
                     /old_locus_tag="A7Q05_2955"
                     /pseudo=""
     CDS             2679..>2855
                     /locus_tag="A7Q05_RS00025"
                     /old_locus_tag="A7Q05_2955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_499250.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0050380 - undecaprenyl-diphosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016311 - dephosphorylation [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /name="undecaprenyl-diphosphate phosphatase"
     gene            2912..3585
                     /locus_tag="A7Q05_RS00030"
                     /old_locus_tag="A7Q05_2956"
     CDS             join(2912..3458,3458..3585)
                     /locus_tag="A7Q05_RS00030"
                     /old_locus_tag="A7Q05_2956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /ribosomal_slippage=""
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WP_237268567.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSNNTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            <3726..4361
                     /locus_tag="A7Q05_RS00035"
                     /old_locus_tag="A7Q05_05200"
                     /pseudo=""
     CDS             <3726..4361
                     /locus_tag="A7Q05_RS00035"
                     /old_locus_tag="A7Q05_05200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009251744.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /name="aminoglycoside 6-adenylyltransferase"
     gene            4358..4888
                     /gene="sat4"
                     /locus_tag="A7Q05_RS00040"
                     /old_locus_tag="A7Q05_2958"
     ARG             4359..4885
                     /name="sat4"
                     /gene="sat4"
                     /gene_name="streptothricin N-acetyltransferase Sat4"
                     /tool="amrfinderplus"
                     /drug_class="STREPTOTHRICIN"
                     /identity="97.78"
                     /coverage="100.0"
     gene            4981..5775
                     /gene="aph(3')-IIIa"
                     /locus_tag="A7Q05_RS00045"
                     /old_locus_tag="A7Q05_2959"
     ARG             4982..5772
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            6257..>6732
                     /locus_tag="A7Q05_RS15575"
                     /pseudo=""
     CDS             6257..>6732
                     /locus_tag="A7Q05_RS15575"
                     /inference="COORDINATES: protein motif:HMM:NF024676.4"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="WYL domain-containing protein"
                     /name="WYL domain-containing protein"
     gene            complement(6791..7465)
                     /locus_tag="A7Q05_RS00065"
                     /old_locus_tag="A7Q05_2961"
     CDS             complement(6791..7465)
                     /locus_tag="A7Q05_RS00065"
                     /old_locus_tag="A7Q05_2961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105991.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            7727..7912
                     /locus_tag="A7Q05_RS15340"
     CDS             7727..7912
                     /locus_tag="A7Q05_RS15340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001037130.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            complement(8135..8713)
                     /locus_tag="A7Q05_RS00070"
                     /old_locus_tag="A7Q05_2963"
     CDS             complement(8135..8713)
                     /locus_tag="A7Q05_RS00070"
                     /old_locus_tag="A7Q05_2963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690637.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(8977..9357)
                     /gene="blaI"
                     /locus_tag="A7Q05_RS00075"
                     /old_locus_tag="A7Q05_05220"
     ARG             complement(8981..9357)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.41"
                     /coverage="100.0"
     gene            complement(9347..11104)
                     /gene="blaR1"
                     /locus_tag="A7Q05_RS00080"
                     /old_locus_tag="A7Q05_05225"
     ARG             complement(9351..11104)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.38"
                     /coverage="100.0"
     gene            11211..12056
                     /gene="blaZ"
                     /locus_tag="A7Q05_RS00085"
                     /old_locus_tag="A7Q05_2970"
     ARG             11212..12053
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(12582..13001)
                     /locus_tag="A7Q05_RS00095"
                     /old_locus_tag="A7Q05_05235"
     CDS             complement(12582..13001)
                     /locus_tag="A7Q05_RS00095"
                     /old_locus_tag="A7Q05_05235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418034.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_000418035.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            13125..14096
                     /locus_tag="A7Q05_RS00100"
                     /old_locus_tag="A7Q05_2973"
     CDS             13125..14096
                     /locus_tag="A7Q05_RS00100"
                     /old_locus_tag="A7Q05_2973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="WP_000481279.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(14268..14360)
                     /locus_tag="A7Q05_RS15280"
     CDS             complement(14268..14360)
                     /locus_tag="A7Q05_RS15280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001791613.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(14517..14864)
                     /locus_tag="A7Q05_RS00105"
                     /old_locus_tag="A7Q05_2974"
     CDS             complement(14517..14864)
                     /locus_tag="A7Q05_RS00105"
                     /old_locus_tag="A7Q05_2974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000119690.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(14883..15500)
                     /gene="cadD"
                     /locus_tag="A7Q05_RS00110"
                     /old_locus_tag="A7Q05_2975"
     ARG             complement(14887..15500)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(16616..16810)
                     /locus_tag="A7Q05_RS00115"
                     /old_locus_tag="A7Q05_05240"
     CDS             complement(16616..16810)
                     /locus_tag="A7Q05_RS00115"
                     /old_locus_tag="A7Q05_05240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001004925.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            16920..17612
                     /locus_tag="A7Q05_RS00120"
                     /old_locus_tag="A7Q05_2977"
     CDS             16920..17612
                     /locus_tag="A7Q05_RS00120"
                     /old_locus_tag="A7Q05_2977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative immunity/bacteriocin fusion bifunctional
                     protein"
                     /protein_id="WP_000691527.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="putative immunity/bacteriocin fusion bifunctional
                     protein"
     gene            complement(17780..17929)
                     /locus_tag="A7Q05_RS15365"
     CDS             complement(17780..17929)
                     /locus_tag="A7Q05_RS15365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000695366.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(18476..>18765)
                     /locus_tag="A7Q05_RS00125"
                     /old_locus_tag="A7Q05_05245"
                     /pseudo=""
     CDS             complement(18476..>18765)
                     /locus_tag="A7Q05_RS00125"
                     /old_locus_tag="A7Q05_05245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009384749.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(18785..19768)
                     /locus_tag="A7Q05_RS00130"
                     /old_locus_tag="A7Q05_2980"
     CDS             complement(18785..19768)
                     /locus_tag="A7Q05_RS00130"
                     /old_locus_tag="A7Q05_2980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_001181107.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFENRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            20194..20937
                     /locus_tag="A7Q05_RS00135"
                     /old_locus_tag="A7Q05_2981"
     CDS             20194..20937
                     /locus_tag="A7Q05_RS00135"
                     /old_locus_tag="A7Q05_2981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_000843732.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(21164..21349)
                     /locus_tag="A7Q05_RS00140"
                     /old_locus_tag="A7Q05_2982"
     CDS             complement(21164..21349)
                     /locus_tag="A7Q05_RS00140"
                     /old_locus_tag="A7Q05_2982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276570.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000797248.1"
                     /translation="MKNRIREYRKQKGISQETLSKELKVSRQTINAIENNKYDPTLTLA
                     FKLARLFDTTVDELFS"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(21354..21692)
                     /locus_tag="A7Q05_RS00145"
                     /old_locus_tag="A7Q05_2983"
     CDS             complement(21354..21692)
                     /locus_tag="A7Q05_RS00145"
                     /old_locus_tag="A7Q05_2983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001049146.1"
                     /translation="MNLIPFIIILIFSCLWTAITNKYLPSETLDKKGQQDRYDERQRKM
                     FIEILAKSFIWIVYCMLFTLVLKFTGLSPSIEGSWFSQYPEIFFIIVALFLMLFNYYTT
                     NKKYTSKG"
                     /name="hypothetical protein"
     gene            complement(21938..22546)
                     /locus_tag="A7Q05_RS00150"
                     /old_locus_tag="A7Q05_2984"
     CDS             complement(21938..22546)
                     /locus_tag="A7Q05_RS00150"
                     /old_locus_tag="A7Q05_2984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000583528.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTFGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKDVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGKAISKIAKEVNITRQTVYRIKHDKGLS"
                     /name="recombinase family protein"
     gene            complement(23032..23931)
                     /locus_tag="A7Q05_RS00155"
                     /old_locus_tag="A7Q05_2985"
     CDS             complement(23032..23931)
                     /locus_tag="A7Q05_RS00155"
                     /old_locus_tag="A7Q05_2985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000196697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mph(C) family macrolide 2'-phosphotransferase"
                     /protein_id="WP_000196697.1"
                     /translation="MTRHNEIIKCAEKYQLHIQPQTISLNESGLDFQVAFGKDKHGVEW
                     VLRLPRRPDVYKRTKPEKQTVDFLQKNVSFEIPKWKVHAKDLIAYPKLTGKPAATIDPE
                     IQNYVWEIEHKPLPENFINTLAETLVDLHNIPEENINVQHINIKTIQEIKNDFQRRMNK
                     VKETYGVSDELWNRWKQWLENDELWPRHATMIHGDLHPGHIMVDNQANVTGLIDWTEAT
                     HSDPSMDFIGHHRVFDDEGLEQLITAYGKAGGEIWPRMKEHIIELNAVFPMFIAEFAME
                     SGESAYETMALKELGMKE"
                     /name="Mph(C) family macrolide 2'-phosphotransferase"
     gene            complement(24030..25496)
                     /gene="msr(A)"
                     /locus_tag="A7Q05_RS00160"
                     /old_locus_tag="A7Q05_2986"
     ARG             complement(24034..25496)
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            25970..26644
                     /locus_tag="A7Q05_RS00165"
                     /old_locus_tag="A7Q05_2988"
     CDS             25970..26644
                     /locus_tag="A7Q05_RS00165"
                     /old_locus_tag="A7Q05_2988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WP_001105960.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     ARG             complement(23036..23931)
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(24031..25496)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             complement(23033..23931)
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             4371..4888
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="97.16"
                     /coverage="95.56"
     ARG             11212..12056
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     ARG             3763..4064
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.0"
                     /coverage="36.23"
     Typing          complement(18273..18420)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          complement(18479..18654)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="92.697"
                     /coverage="94.0"
                     /evalue="1.04e-65"
     Typing          complement(18786..19768)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.593"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          20195..20937
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 ggtgacgtat gaatttcttg aaatcaatcc aacgtgaaat ttatattgtc atccttactt
       61 gtgctttatt ctactttata ttattcatgt ataatgtgcc gatgcaagca tatatgattg
      121 gtctaggtat tgtattgttt gtttcaatga tttactgggg tatccattac atgaacttta
      181 aaaaagaata aacactacag gaacagaacg aagatttaag aatcgaaaac cataaacttc
      241 gtaatgactt tattaactac caaagtgagt tagagtcata ttttttaatg tgggtgcatc
      301 aaatcaagac accgattaca gcatcaaagt tactgcttga agatcctgat gaacacgtga
      361 tttctaacgt gcgtaatgaa gtcttacaaa ttgataatta cacgaatctt gcactgaact
      421 atttgaaact catgaaccaa aagacataca tggtctttat ggaagtgagt gtagatgaat
      481 taattcgacc actgattaaa cgttatgcga tacagtttat tcatcatcaa acaaagttgc
      541 attatgagaa aagtgaagcg gttatattaa cagatgccaa atgggcatca attatgattg
      601 agcaaatatt aaacaatgca ttaaaatatg cacgtggcaa agatgtgtgg attacgtttg
      661 acgaaaatac aaagaaatta tcaatccgag ataacggtat cggcattaat gcgagtgatt
      721 taccgaaaat ctttgataaa ggtttctcgg gctataacgg tagaataagt gagaaatcaa
      781 gcggtattgg tttatatatt gtcagcacaa tctcaaagcg cttaggccat aaagtaagtg
      841 ctacatctac attaaacgat ggttcaatat tcaccattca atttaaataa ctccaatctt
      901 tcatttttgt aagattagcg gctgtttttg taagaataga taaaggcagc cttttctaat
      961 cgcgcgtaag ataaaggtaa caacaaacta agaaaggtgc cagaggtgaa aaatttgaat
     1021 aatataattg aaataaataa cttaacaaag caatatggaa gtcagatagc agttaataat
     1081 ttgagtataa ctgttgaaag tggacaaatt tatggttttt taggaagaaa tggtgcaggc
     1141 aaaacaacta ctataagaat gcttttaggc ttaattaaac ctacgaaagg taatattaaa
     1201 atatttgaaa aagagttcga aagtaataaa actgaaattt taaaaaatat tggtgctatg
     1261 gttgaaacgc caggttttta tagtaatttg acagctaaag agaacttaac tataaatgct
     1321 aaaatattag gtatacaaaa agaaaatgca attgaagaag tgttagaaat agtaggacta
     1381 gcttctgaaa aagtaaaatt gtttaaaaat tattctttag gtatgaagca acgtttaggg
     1441 attgcgagag ctttattgca caatcccgaa ttattgatac ttgatgagcc gacgaatgga
     1501 ttagatccta ttggcataaa agaaattaga aagttgatta aggatctggc tcaatctaga
     1561 aatataacca ttttaatttc aagtcatata ttgtcagaaa tagagcagtt agtagacaag
     1621 gtgggtatta ttcataacgg agttttgtta gaagaaatta tgtatgaaga tttaaaaaaa
     1681 aagaacagac aatttataag tatatcagta tcagatgaag aaaaagttgc atgtttgttg
     1741 gaaactaact tcggaattta tgactataaa attaaagaaa atggcgaatt taaaatttat
     1801 tcacatattg atagacaaca agaaattaat agattattag tattaaacaa tattgatgtt
     1861 ttccagatga gagtgataga agataatcta gaaacttatt tcgaagactt agtaggaggt
     1921 ggcacaattg gataatctac tccgtacaga atttattaag ttaaaaagat catatatgtt
     1981 tctaataagt attttaggta catgcgtagc accttttatg gtggttgtag cttcttttat
     2041 tagtatgcgg acgaaagtac cgactcctaa tattgtattt aaacagttat ttgaagaagt
     2101 cagtttatat catatgctaa ttattggacc tcctctatat ggggttataa tagcctattt
     2161 gtttggaaga gaatatatag aagatacttt aaaaaactta ttaattatac ctatatctag
     2221 agaaagtttt ttagtaagta aaataatatt attattcttg tggattcaaa cactatctgt
     2281 tattgcatgg ttgctaactt taatgctagg tatgctattg cattttcaag ggttaagcca
     2341 gagtttaata attgattcat tctttacatt tgttattggc ggagtgttat tatggatatt
     2401 atctccacca ataattattt tgtcgatata ttttaaaaat tatgttccca caattgtttt
     2461 aaccataata attactttga taaatttaat gactgctaat tctgaacata gaggattatt
     2521 tccttgggct gcagttggag acatatctag aggaacatta cctaatactt atccatttct
     2581 attatcttta attatcataa ttgttacatc tatattcagt gtaattatat tattctcata
     2641 ctttaaaaaa actgatataa gttaaaagga ggagaaaaat gggttttata gagcagatta
     2701 aagcatttat tttaggtgta gttgaagggt tgacagaatt tgctccagta tcatcaacag
     2761 gtcatatgat tattgttgat gatatgtggt taaacactgc tgacgattta ggaagtgcgt
     2821 ctgcaactac ttttaaggtg gtaatacagt taggaggttc tgttgcaaag ttgaatttat
     2881 aatataattt taacaaaaag gagtcttctg tatgaactat ttcagatata aacaatttaa
     2941 caaggatgtt atcactgtag ccgttggcta ctatctaaga tatgcattga gctatcgtga
     3001 tatatctgaa atattaagag aacgtggtgt aaacgttcat cattcaacga tctaccgttg
     3061 ggttcaagaa tatgccccaa ttttatatca aatttggaag aaaaagcata aaaaagctta
     3121 ttacaaatgg cgtattgatg agacgtatat caaaataaaa ggaaaatgga gctatttata
     3181 tcgtgccatt gatacagagg gacatacatt agatatttgg ttgcgtaagc aacgagataa
     3241 tcattcagca tatgcgttta tcaaacgtct cattaaacaa tttggtaaac ctcaaaaggt
     3301 aattacagat caggcacctt caacgaaggt agcaatggtt aaagtaatta aagcttttaa
     3361 acttaaacct gactgccatt gtacatcgaa atatctgaat aacctcattg agcaagatca
     3421 ccgtcatatt aaagtaagaa agacaaggta tcaaagtaca atacagcaaa gaatacttta
     3481 aaaggtattg agtgtattta cgctctatat aaaaagaacc gcaggtctct tcagatctac
     3541 ggattttcgc catgccacga aattagcatc atgctagcaa gttaaacgaa cactgacatg
     3601 atatattagt gattagctat attttttact ttgcaacaga accatcattt ttattaaaat
     3661 actcttttgt aaaatctttc tgctcttcaa tgtatttaat ttctttacct ctaaatctat
     3721 tatagctatt tgatgattac aataaaattg atcttacctt attgcccttg gaagagttag
     3781 ataattacct aaagggcgat aaattaataa aggttctaat tgataaagat tgtagaatta
     3841 aaagggacat agttccgact gatatagatt atcatgtaag aaagccaagc gcaagggagt
     3901 atgatgattg ctgcaatgaa ttttggaatg taacacctta tgttattaaa ggattgtgcc
     3961 gtaaggaaat tttatttgct attgatcatt ttaatcagat tgttcgccat gagctgctga
     4021 gaatgatatc atggaaggtc ggcatcgaaa caggctttaa atgaagtgta ggcaagaact
     4081 ataagtttat tgaaaggtat atatccgagg atttgtggga gaaacttttg tccacctacc
     4141 ggatggattc ctatgaaaac atatgggaag cattatttct atgccatcaa ttgttcaggg
     4201 cggtatccgg tgaggtggcg gaaaggcttc attatgccta tccggagtat gataggaata
     4261 taacaaaata taccagggac atgtataaaa aatacactgg taaaaccggc tgcctggata
     4321 gcacatatgc cgctgatata gaagagaggc gggaacagtg attacagaaa tgaaagcagg
     4381 gcacctgaaa gatatcgata aacccagcga accatttgag gtgataggta agattatacc
     4441 gaggtatgaa aacgagaatt ggacctttac agaattactc tatgaagcgc catatttaaa
     4501 aagctaccaa gacgaagagg atgaagagga tgaggaggca gattgccttg aatatattga
     4561 caatactgat aagataatat atctttacta ccaagacgat aaatgcgtcg gaaaagttaa
     4621 actgcgaaaa aattggaacc ggtacgctta tatagaagat atcgccgtat gtaaggattt
     4681 cagggggcaa ggcataggca gcgcgcttat caatatatct atagaatggg caaagcataa
     4741 aaacttgcat ggactaatgc ttgaaaccca ggacaataac cttatagctt gtaaattcta
     4801 tcataattgt ggtttcaaaa tcggctccgt cgatactatg ttatacgcca actttgaaaa
     4861 agctgttttc tggtatttaa ggttttagaa tgcaaggaac agtgaattgg agttcgtctt
     4921 gttataatta gcttcttggg gtatctttaa atactgtaga aaagaggaag gaaataataa
     4981 atggctaaaa tgagaatatc accggaattg aaaaaactga tcgaaaaata ccgctgcgta
     5041 aaagatacgg aaggaatgtc tcctgctaag gtatataagc tggtgggaga aaatgaaaac
     5101 ctatatttaa aaatgacgga cagccggtat aaagggacca cctatgatgt ggaacgggaa
     5161 aaggacatga tgctatggct ggaaggaaag ctgcctgttc caaaggtcct gcactttgaa
     5221 cggcatgatg gctggagcaa tctgctcatg agtgaggccg atggcgtcct ttgctcggaa
     5281 gagtatgaag atgaacaaag ccctgaaaag attatcgagc tgtatgcgga gtgcatcagg
     5341 ctctttcact ccatcgacat atcggattgt ccctatacga atagcttaga cagccgctta
     5401 gccgaattgg attacttact gaataacgat ctggccgatg tggattgcga aaactgggaa
     5461 gaagacactc catttaaaga tccgcgcgag ctgtatgatt ttttaaagac ggaaaagccc
     5521 gaagaggaac ttgtcttttc ccacggcgac ctgggagaca gcaacatctt tgtgaaagat
     5581 ggcaaagtaa gtggctttat tgatcttggg agaagcggca gggcggacaa gtggtatgac
     5641 attgccttct gcgtccggtc gatcagggag gatatcgggg aagaacagta tgtcgagcta
     5701 ttttttgact tactggggat caagcctgat tgggagaaaa taaaatatta tattttactg
     5761 gatgaattgt tttagtacct agatttagat gtctaaaaag ctttaactac aagcttttta
     5821 gacatctaat cttttctgaa gtacatccgc aactgtccat actctgatgt tttatatctt
     5881 ttctaaaagt tcgctagata gagttctata ttagagatgt aaagagtttt ggtgaagagg
     5941 tttgtgagta tggcttttat aaccagggtg caatgagaag cactaacagc agctagctta
     6001 agaacgcata ggatatactt tttatggaag tcacagagga ggaataaaat ttgaacagga
     6061 ttaacagagt aacctctatt cttattcagc tgcaatcaaa aaaataattc ctgccaaaga
     6121 aattgcacag cgatttaata taagcttaag gacagtttac agagatatcc ggacacttga
     6181 agaagccgga ataccaattg gatctgaggc cggaaaagga tattttcttg tagagggctt
     6241 cctacttctg ccggtaatgt ttacagcggc ggaagtgggt gcattgatta cagcagggaa
     6301 atttttaaat tgccatggag atgaatcatt tataaaggat tttgattcag ctatgtataa
     6361 aatcaaatct attttgaagc atggtgaaaa aaactatgca caggagttgg agaacagtat
     6421 taacgtgtac agcacatctg gacagaaaaa tacattggcg gataacgtta ttgcagcaat
     6481 tcagactgca atctgcaata aaagggtaat atcaattcaa tatcctgcat caggagggca
     6541 agaaccggaa agcagaatga tagagcctat atcactgggg ttttatgaac agaactggta
     6601 cttaatcggt tttgcaggct aagaaatgaa tataggaatt ttcgtgtgga tcggattaaa
     6661 agcatttgca tagaagaaga gctctgtcaa agccatgatg gctctttgga acaaatatta
     6721 aaacaaatgc tggttctgtt gcaaagtaaa aaaatatagc taaccactaa tttatcatgt
     6781 cagtgttcgc ttaacttgct agcatgatgc taatttcgtg gcatggcgaa aatccgtaga
     6841 tctgaagaga cctgcggttc tttttatata gagcgtaaat acactcaata ccttttaaag
     6901 tattctttgc tgtattgata ctttgatacc ttgtctttct tactttaata tgacggtgat
     6961 cttgctcaat gaggttattc agatatttcg atgtacaatg gcagtcaggt ttaagtttaa
     7021 aagctttaat tactttaacc attgctacct tcgttgaagg tgcctgatct gtaattacct
     7081 tttgaggttt accaaattgt ttaatgagac gtttgataaa cgcatatgct gaatgattat
     7141 ctcgttgctt acgcaaccaa atatctaatg tatgtccctc tgcatcaatg gcacgatata
     7201 aatagctcca ttttcctttt attttgatgt acgtctcatc aatacgccat ttgtaataag
     7261 cttttttatg ctttttcttc caaatttgat ataaaattgg ggcatattct tgaacccaac
     7321 ggtagaccgt tgaatgatga acgtttacac cacgttccct taatatttca gatatatcac
     7381 gataactcaa tgcatatctt agatagtagc caacagctac agtgataaca tccttgttaa
     7441 attgtttata tctgaaatag ttcatacaga agactccttt ttgttaaaat tatactataa
     7501 attcaacttt gcaacagaac ctcatttact atatgggcat ctctttcatt attaatacaa
     7561 agctttgtat ctccgatatt aggcaaaggt gtaaacgaat taggtgatac tataggattc
     7621 aacattatat taatcgtttc tttaataatg attatcttct tattttttat aaatcgtagt
     7681 aaaaatatct cctatgatta tataaaagtt caaagaggtg aagccaatga ataaattaga
     7741 aaaatggtct ttggtattta ttatttttac atttctctct tcattagcac ttttatattt
     7801 caaatataat tttagttcgg ttatgccagt cctaagtctt tctattttaa ctatactaat
     7861 attgttgacg agtattatta ctgtagtttc agttaatgat gaagatactt aaaacgttca
     7921 ttagtgaaac aggtattata ttaaaaaagc gtacgaattt gtacgctttt ttcttgtgtt
     7981 attattaaaa tctcataaca ggaaaatatt atgagatttt agacgctgtc agaacgtctc
     8041 ttttacatcg agtgacattg aatcaaagtc tttgtatgtt aatgatatat aaaattattt
     8101 agtagattca ttatagtaag ctagattagt tgctctactt gtttttattc tcttttgcct
     8161 ctaatttatt gagataacga taaatagttg tacgtgaaac ttgccactgc tctgcaattg
     8221 ttttaattgg cgtaccatta tcataaagtg tcttaagtaa gtttaaatct tgtttattta
     8281 atttttcagg tctacctcca tatcggcctc tagcacgtgc tgcaattcga ccggctgatg
     8341 atcgctctaa aattaaatta cgttcaaact ctgcaaatgc tgcgaataaa tgaaataata
     8401 attgtcctgt agaacttgat ttatccatcg ttatattttc ttctaaacta tgaaaactca
     8461 cacctcgttc gttaagttca ttaactaacg tgattaaatc ctccatgttc cgtcctagtc
     8521 tatctaatct ccaaacaaca atcgtatctc ctgacctcgc aaattcaatt gctttatcta
     8581 aaccaggtcg cttacttttt gaaccactca tatggtcatt aaatatcttt tcacaaccat
     8641 atgtatttaa tcgatcctcc tgtaaattca aattttgtaa tccagttgaa actcttgcat
     8701 aacctatttt caaaatacag acctcctata tacaccttta gtgtaccata acttgattac
     8761 gaggtctttt gtgaacatag attttttgtt gggtttttga acacataatt ctatgtaata
     8821 cttacttatt tagacaaaaa acaagagtgt acagaaaatg gttattttct ggacactctc
     8881 atctttaata atatatttta aatgtcatta acaaaactaa tttaataaga gtcaagtatg
     8941 gtttacatat gtattatgtt tgaaacatac ctctaattac tttttactaa tatcatttaa
     9001 aatgtctcgc aattcttcaa tttctttgtt atttaattct tcatttttcg caaaattcag
     9061 cactaaactt ttcatatccc ctccatacag tttattaaga aaggttttag cagttttcat
     9121 tttaatatcg tcttctttaa tatttgatga gtaaaaataa atattttctg atttgtatcg
     9181 ttttataatc tcttttttat atagtcttgt gattaatgtt ctaatcgttt tatcactaac
     9241 ttctttatat ttttgaattt caactacaat ttcattagct gatactgatt ttttatccca
     9301 tattatattc ataacatccc attcagccat agatatttca acttgcttat tggtcattta
     9361 aaacacccat tccttttaat attttttcac ttattaattc agcatttttc ccagacgggt
     9421 ttccatctga taaatgtgta gcaaaataat acttatcatg atttgtaatt acgtaaccta
     9481 caaaccaccc attattatac ttcccgttta ctatacctgt acctgttttc ccatacagtt
     9541 catacttttc atttttctta atcaataatg aagaagataa ttgattcttt gcttttttac
     9601 taaaatggtt attttgttcc atcatatttt taaaaactat tacttgttca agattagata
     9661 ttttcaaact atcttccatc caatagcttt tataacttcc caaattttca ttaccataat
     9721 ttaattgctt gagttgagcc gcagtatagt tctttggtat ttgattacta atacgttcga
     9781 agtaccaatt aactgaattt tgcattgctg tatttaaatc ttgttcctta ttccaagact
     9841 cgaaaagata atgtttatga ttccatgaca tacgtgaatt tttatcactt ataatatgac
     9901 ggtcaagtcc aaacagtgct aaataaattt tgtaagttga atcaggagaa tatctttttc
     9961 tactttcttt ttcattataa atatagtatt tgtctttctt catgctgtac ataacgaaag
    10021 atccactatt tgaaccaaaa tttttacttt catctaaaat ttggtaatcg ctttgtaagg
    10081 gctttttata attataatca gttaaggatt gccccattaa aaactggctt tgaattatca
    10141 tgataaaaaa agtaaaaata caaataaaaa ttagaattaa ttttgactgc tttttcagat
    10201 cggcttcttt tatattaatt aatctacttt tgagtaatga ttttttacca ttaaatgaat
    10261 ggcttaatat atttttgttg gaaaatgggg tttttaatac ggagtccata atagattccg
    10321 cataagtttt aaattcattt ttgttaatat tattaaggac aaatctatcg gcttctactt
    10381 cattgtcatg aattatcttt ctttttacaa tatgtactaa tggattgtaa ctcataataa
    10441 tagagaagat attaaagata attaaatgta aagtatctct atttttagca tgagcatatt
    10501 catgcagtat tatatatttt agtcttttat caattacact tttaaaatat gaactaggaa
    10561 tcaaaataat atatttccca taccaaaaag ttattggaga ttgaatagcc tctgcttttc
    10621 gaatcacaat atttttttta tattgatggt tgaaaagtat cgtatctatt ttattttttt
    10681 cattttcgtt tagataaagt gactgtttct ttaaatattt aagatataat aaggctttca
    10741 aaaatttaaa acttaaaata ataactaaaa ctatccaaat aactgtgcag atattatcaa
    10801 ttgaatccca attaaactta tggatatctg ttgtgaactc ttgaataggt ttggtggtat
    10861 ttatgttatg gttcaaatcg tgtgacttac tttcaactgt gggcgcttga ttattcacat
    10921 tattaaattt tataaaagag aatttaattg ggataaaagg aattaatcca gcaagcatag
    10981 ttagatacca aactttataa tttaaactat aattaaaata gcgttttaat atgtacctaa
    11041 aaaatactaa caatagaaat ataaaacaaa agcttactac gctcattatt agtaatttag
    11101 ccattttgac accttctttc aaatatttat aataaacaat tgacatcaat attacaattg
    11161 taatattatt gatttataaa aattacaact gtaatatcgg agggtttatt ttgaaaaagt
    11221 taatattttt aattgtaatt gctttagttt taagtgcatg taattcaaac agttcacatg
    11281 ccaaagagtt aaatgattta gaaaaaaaat ataatgctca tattggtgtt tatgctttaa
    11341 atactaaaag tggtaaggaa gtaaaattta attcagataa gagatttgcc tatgcttcga
    11401 cttcaaaagc gataaatagt gctattttgt tagaacaagt accttataat aagttaaata
    11461 aaaaagtaca tattaacaaa gatgatatag ttgcttattc tcctatttta gaaaaatatg
    11521 taggaaaaga tatcacttta aaagaactta ttgaggcttc aatgacatat agtgataata
    11581 cagcaaacaa taaaattata aaagaaatcg gtggaatcaa aaaagttaaa caacgtctaa
    11641 aagaactagg agataaagta acaaatccag ttagatatga gatagaatta aattactatt
    11701 caccaaagag caaaaaagat acttcaacgc ctgctgcttt cggcaagact ttaaataaac
    11761 ttatcgcaaa tggaaaatta agcaaaaaaa ataaaaattt cttacttgat ttaatgttta
    11821 ataataaaaa cggagacact ttaattaaag atggtgttcc aaaagactat aaggttgctg
    11881 ataaaagtgg tcaagcaata acatatgctt ctagaaatga tgttgctttt gtttatccta
    11941 agggccaatc tgaacctatt gttttagtca tttttacgaa taaagacaat aaaagtgata
    12001 agccaaatga taagttgata agtgaaaccg ccaagagtgt aatgaaggaa ttttaatatt
    12061 ctaaatgcat aataaatact gataacatct tatagtttgt attatatttt gtattatcgt
    12121 tgacatgtat aattttgata tcaaaaactg attttccctt tattattttc gagatttatt
    12181 ttcttaattc tctttaacaa actagaaata ttgtatatac aaaaaatcat aaataataga
    12241 tgaatagttt aattataggt gttcatcaat cgaaaaagca acgtatctta tttaaagtgc
    12301 gttgcttttt tctcatttat aaggttaaat aattctcata tatcaagcaa agtgacaata
    12361 gcattttaca agtatttttt attgttcgat tagggtaaac ctaaataata cataaattat
    12421 attacaatat gtttattata gaggctaaag tatcttagaa atttggatag taggtttttc
    12481 gggaataaaa gtatagttgg ctttaatata taattaagct aagctatcat ttatatttac
    12541 tcgattataa ttcgcacttc aactttttta taacgtaaaa attaaaacgt agttttattt
    12601 atctttagta atatcttttt aaacactaca gtttcttcat tagttaaatt agcgaagtaa
    12661 tgattattaa gttgataggc tttcttttct aatgttggcc ataagtcttt tgctttattt
    12721 gtactgttta ttagcacagt tcttctattt tcattatcag tttgacgtgt tattagatcc
    12781 tttttggaca tcttatctaa tattccagat attgttgaag gttctaaatt taaagtatta
    12841 ccaatcgctt taggtgtatt caaattacta ttaatcaagc aattcaaaac accatattct
    12901 gctggagtaa tattataggg acttaataaa cttttaaaat gtttaaaaac tctattctga
    12961 gaagtactca acaaataatt tatacaatta tctaattcca caactaaaac ctctcttaaa
    13021 tcattagtat tgactcgctt atcatatcat gataagtttt gtaggaaaat agttttgcaa
    13081 caaaaacata cttctacaaa acaattgtga aagaaggcta ataaatgttc aatgcggtag
    13141 tagtgagaaa aagtgcatca aatgttagtt ataaagtaga aaaagttgat gaatctcatt
    13201 tatcgaaggg tgatgtatta gtaaaagtgg tatactcttc aataaattat aaggatatgc
    13261 tagctttaca atataaaggc ggtgtaatta gagattatcc tatgattcct ggtatagatt
    13321 ttgcaggtat tgttgaatca agttcgaatg ataagtttaa agaaggcgat aatgtattag
    13381 ttactggtta tgatgttggc gtgacacata caggtggatt ttcagaatat gcacaagtgc
    13441 ctggagagtg gattgttcct attccccaag aaatgtctat taaagagtct atggtatatg
    13501 gcacagccgg ttttacggca gcattatcaa tttttgaact agaaaaatat ggaatgaata
    13561 tcaaatcaca acctgaaatt ttagtgtctg gggctacagg tggtgtgggc agtgttgcta
    13621 tacaaatttt acataaaatt ggatatgaaa atatcactgc tatcgtaaga aaagaaaagc
    13681 aaatagaaat cgcaaaaaaa ttaggtgcaa aacaagtaat aataattgaa gatgataata
    13741 aaccgcttaa aaaaggtatt tttgattatt tcttagatac agtggggagt aatgtaacat
    13801 tatacggttt aaaacgtcta aattatcaag gtgttgctac tgtatgtgga aatgtagcag
    13861 gaaattcact taacgctaat atattaccgt ttattcttag aggtattaaa ttaattggca
    13921 ttgattctgt atatgttgat cataatatcc gtgaagatat atggagtaag ttagcaaatg
    13981 aatggaatat aggaaattca cttctataca atgaaattgg atttgaagaa ttctataaaa
    14041 cgatagatca gcttttaaaa ggacaacatt taggaagaac tattttaaaa gtataagtgt
    14101 gagtattcat taatacattt actattaatt caatcatttt gcatttctct actaaccagt
    14161 gttataattt atataacgaa aatgattaac aattaatgca ccaatcccca cactattgca
    14221 gtagtgtggg gattttttcg atgctggctt ataaagtcgc ctattaatta tttgttgcgt
    14281 ttactaagcc aataagtata atacgcaaca gcacagccac tgatgactgg tgctatgatg
    14341 tgaacgaaaa tgattagcaa agtaatgcac ctcctctctt cgtcaattga cgcctgagag
    14401 ataggcgact ctattattat accatctgtg aatatacaag catatctact tccgataagt
    14461 cgtcttatgt tatataactt tgttttttat agtatcaaga caagaagaaa ctcgtttcaa
    14521 aaaccctcat gatttttaga gaaaaactct cttatttcat cgtctttaat aaaataatat
    14581 gccatctttc catctttata aaaatcaagt acctcatttt tatataaaag ccttaaatga
    14641 tgtgaagttg aagcaacact cattttcaat atcaaagaaa tatcacaaac acacaactca
    14701 tcttctttaa tcaaagataa tatgattttc aatttcttct catcacaaat tttttctaaa
    14761 atgttaagta atttcttaga tttatcatct tctaaaaaac ttaaagcatt gttaacttta
    14821 tcctcatgta cacagatcac atcacaagta ttttcataac tcatataaaa tcacacccta
    14881 aattaaaata taaatcctaa aattgtttga atagtgtcat tttcaataat aataaataaa
    14941 cctaaagcta tataaataat agccataatc caacgactaa atttctcaac aatttctcca
    15001 attcctggaa tattagctaa tttttgtgca gtaaacacca agaagaaaat taaaattaaa
    15061 aagacaaaca gagtaagtaa taaattagta acacttaatg tcacaaaata cggaacaaat
    15121 aaaccaatat tatcggcgcc acaacttgct atcgtaacaa ttgcaaccgt accaactaat
    15181 ttagacaatc ctttttcatt caattctttt ttagctctct tttctccttc acaatcatca
    15241 taaatagcca ctttaattcc aagataaatt ggtattaaac ccaataaacc taatatccac
    15301 ttttctggaa cataatttaa tacaaaagct aaaaacaaac taactaatat taaaataata
    15361 gaccctaaat attgaccaac ataaatatct ctatattctt ttctagtctt tgctctagca
    15421 aaaaatatta ataaaattac taataaatca actgctgtag caatataaag aacagcagca
    15481 gcaacaaccg tttgaatcat aatacacctc attcaaaaat atttttgaat gtattataac
    15541 ttatattttt aaataatcat aggtgcttta ttccaattgc tttattgacg ttgagcctcg
    15601 gaacccttaa caatcccaaa acttgtcgaa tggtcggctt aatagctcac gctatgccga
    15661 cattcgtctg caagtttagt taagggttct tctcaacatc aataaatttt ttcggcataa
    15721 atgcgtgtct atgcgtagac atggagacac ttcagaatta tggagtgatt acatgagttt
    15781 aactattttt ctttattcag ttttaggaag tttattagca aattatatct acgaaaaatc
    15841 ttcaaaataa ataacttttt cggttctact ttgtacactt tatctacctg gtagacctaa
    15901 ttgttattgc tttacaggtc taaaattcgt cgttataatc tagttaaatc ccgtaagggc
    15961 gcacttatac gtcggataaa tcgacatgtg caaaaacgta atcgaccttc gtcgattttt
    16021 ttatttcaaa attaaagaaa cggcttgaga tattccgagc agttataaaa attaatttgc
    16081 gttgaatatt gctactacat tcttgaaaaa gtgatgtaga tttatagccc ataacttttt
    16141 tgaattacat cgacgatacg gcgtcgaaag aaaaataaat agaccgtatg aaagaaaaag
    16201 ctacctcact ttatctgggg tagcttttat tttttatgcc cttattttga attttaagag
    16261 ggcattttaa agatttaggg gtgattcata tagttttata tctaaaactt atatatgctt
    16321 ttaaaacgca aatatgagcc aaataaatat atgctatttt caaaaacaaa aatttgagca
    16381 aaaacaataa ctatttttag acactgccca tttacatgca aattaaaaat tagcataaaa
    16441 ttctttaaaa cttccccacg tttttctaaa ttcctgtagg gcgtttttat caaaaatcaa
    16501 gacaagaaga aactcgttca cactcgtttc aaaaaaacaa gaaatctaat ctatacacct
    16561 accgttttcc aaccccctca aagcatacaa attaaaaaca aaattattca taatcttact
    16621 ttcttttaac aaaaacataa aaaccataaa tagacaaatt aactatcaaa ggcaataaac
    16681 agtataaaaa aaccacgaat aaatcttcat caacatctaa aataaaaaag aataaaacaa
    16741 ttaacaaaat actaattaac aaacctaaaa gtggcaaact ttttatatat ttttctaaat
    16801 tttcattcat aaaatagact cctttcaaaa atatgtttat aaatatatta aaataaatat
    16861 tgattttata aagcgcttac ttatacaatt aaaatatctt attatcttgg aggtatcaaa
    16921 tgaaaattat aaaattattt tcaataattt ccttgttcct actggtattt agcgcgaatt
    16981 tttctaatgc ttacgcaaat gaagaacaaa aaagttcttt actagaaaat caaaaagaaa
    17041 aattgaaaag caaaaacatc gaagtatcac aaatgaccaa gaaagaaata agttttctag
    17101 aacaattgca aaataaaaat gaagatatgc aaaaattcga aaagcaaatg aaaaaagaag
    17161 gatttaaaaa aataaagcta gaagacaaaa attctaaatt aaaatatcta gctacagaag
    17221 caaatgataa aaatgcatat ggctacatag ctaataacgc ttataaaaat gaaaaaacaa
    17281 aagaaattgt agtttctgaa acaatatatg ataactacaa caaaaaaatc acaaaattca
    17341 ttgccgaaaa aagaagtatg actgaaaaca aagagggaaa aatacttatt aacaaaaatt
    17401 acgttgaata taaggctgaa aaagttgata aaaacagacc ggtaacatat gcaggattca
    17461 aatggaacgg caaagcattc gcttgtagta tggctggact ttatgcatgt gctcactact
    17521 gtggagtatg ggcaatcgta aatccaatag ccggcggtgt atgtgaagca gtttgcggaa
    17581 ctgcatttgc agctggatgc tctgtaggtt gattttattc caattgtttt attgacgttg
    17641 agcctcggaa cccttaacaa tcccaaaact tgtcgaatgg tcggcttaat agctcacgct
    17701 atgccgacat tcgtctgcaa gtttagttaa gggttcttct caacatcaat aaattttttc
    17761 ggcataaata cgatgttcct tatttatcct cataaaaaac aatagctgaa atatataacc
    17821 aattactgtg tgtttgaatt tctaatacat gaatatcatt ctttaaaaac ctattaactt
    17881 gtttatctaa ttgacgatga gtaaaagtag cgaaagtttt aatcttcatg atatctctcc
    17941 ttttataaaa atagcaatcc ttattacaat attaaacact tttattttgg attttaagag
    18001 gcattttgaa gacttagagg caaatcatat aggttttgta cttaaaaatc tatacagtct
    18061 cttaaaacgc aaatatgagc caaataaata tatgctaatt tcacaaacaa aaatttcagc
    18121 aaaatcagtg actaattttt tagatactgc ccatttacat gcaaatttaa aaattagcat
    18181 aaaatacttt aaaacttccc catgtttttc taaattcctg cagggctttt cttatcaaaa
    18241 acttagaaat tttaatttaa ctctaaaatc tccgtaagag cataagggaa atttgctatc
    18301 attcaaaaat gatagatctg gcaaggccag acattccaag ggttttaagt tattttaaag
    18361 tgatatcata caaagctgta gtgtcacact tttgtgacac tacatacagc atttgtcaca
    18421 aaaataagac agcacttttt tacagaaaaa caataaaaaa agacatcagt tatcactaat
    18481 gtcttaaata ataattttgc ttttcgaaat tccaaattgc ggtaattgaa tgtgcttttt
    18541 ttcttcgtct gtcgttttat cttcatcact tgtattaatc aaattaccat cttcggcatc
    18601 gtctaagttt aaaattttat gcttttgttt aagcaatcca ccataactta acatacgttt
    18661 tcgatacaaa cctttttcta aatcacttac aatttcttga tttttttcgt cgtcatcagt
    18721 taaaaagtca gatgatttaa cggaatattt tgatgtctct tcgagtgtta taaaatcatt
    18781 tgaattattg attaaagata ttatattgtt tcatgttttt acggcgcata taaagggcat
    18841 gtgtttcttc aagttcagtt agaattgttt gcattaaata agcttgcatt gacttgattg
    18901 tttccttttg gcctttaact cccctatcat gtatagcttt tttaagtctt tttaaagaag
    18961 ttaatatttc atcctcaatg tcctctaaca tgtaatgcat atcttcatgc cttgaattaa
    19021 atgatttttt tgctttaaga ataacagcct ttatgatttc taaatctcta taatcatatt
    19081 ttaataaata attagttagt tgttctggga attcttgcaa tagcatttct ttatcatcaa
    19141 aattatgtgt aaattgattt gaatgatttg aatgattact aatttcattt ttgtacttta
    19201 tatcattcaa gtcattcata tcattattct cagtatcatt aaagtcaatg tcattaaagt
    19261 cagtatcatt agtgttcgat tttcgaactt ctggacgttc gattttcgaa cttctggacg
    19321 ttcgattttc gaacttctgg acgttcgatt ttcgaacttc cttctcgccg taaggttcaa
    19381 catcgttttc ttctttttct attttgtaaa tatcacgttc tgtgacaata ggtttcatta
    19441 aatatagaat atttggttta tttaaaccac gtcgtttttg aatgagtaga ccatcgtttt
    19501 ctaacccttt ttttattttt gttaactttt cttttttaca atttaagatt tccattagct
    19561 tttcatttga ataaacaaag taaatgttac catcttcatc aacccagcta tttttaatag
    19621 ataaatttaa gcgatcacgt aagatagcat aggctatttt catatcatta gttagatttt
    19681 tataattttc actggtaaag aatactttag ggatttgata aaatctttct ttgtaatttt
    19741 cttgcactgt aaaatattga ttttgcatga caaaaaacct ctttccatat tttagtttgg
    19801 taagaggtaa taaaacgttt ttatttagct ttacatttat ttaatgattt aggtgcttgc
    19861 actaagatat tattcattat ataatacaag tatcgaaaat tatataaata aacagtttct
    19921 aaacgtttta ttaccaaacc ccgactatta ccagtagttg gggtttttgt tatattaagt
    19981 ttattatagc actttaaata aacttataaa agggaaaata tagctttatc aagggtttat
    20041 aaacccttga taaatatcat aaacctttca taaacccttg ataaaaaggt tgatggatgt
    20101 ttatttttat ttattaatca ctttattatt aagcattata agcttataat attttatcaa
    20161 gggtttataa acattttata aagggttgat gatatgaaaa gtgtgaaaaa gttgagtgaa
    20221 gaattagggg ttagtaagca aacgattttt aataatatta agcgattgaa tatagagaca
    20281 ataaaacagg aaaacacttc gtttattaaa gaagataccg atatagaaaa aatcattcaa
    20341 agagtaaatg aaaataaaaa gaaatatggt tttgaaagta ctactgaaga caaacaaaaa
    20401 aaagggtcgg ataatattaa ttttgaatcg aaaagcgatg ctcaaatagt agaaatcctt
    20461 aaaaatcaga ttgatacttt aaataatcaa attgaaaaac aagaaagtcg tcatgaaaca
    20521 acaattgaat tttacagaaa agagttgcaa gaaagatcaa aattgcttga aaatcagcaa
    20581 gttctggcat tagagagtaa taaaaagatt caaaaattag aaaatcaatt agaaaaagaa
    20641 aaacacctta attatccctt tgatacatct actaacacta gacaaaacgt tgatgcacaa
    20701 gaaaaaacat atactactaa tcctgtaaat attaacagag atcaggaaga aactaaagaa
    20761 acagagattc aatataagga tatatctgga agtcaaagcg acgaaagtac acaaggtgaa
    20821 gaagcaaaaa aagaagacgt tccagctaat ctaaatgaca atgatagtga tatagaagaa
    20881 aagagtgaag aaacggaacc taaaaagggg ttttggagtc gtttgtttgg tagctaaaat
    20941 aattgattag gcactaaaag ttataaaatt ttagtgtctt ttatatagtg agaacttctg
    21001 gtaatcatcg attatgtaaa ctaaagtatt tcaaataatt aactgtatta atactctcat
    21061 catgattgcg ttataaacgt tcgttattga gacaaaattt aatagtacta ctacacaaaa
    21121 agagagtgcg aattcgcact ctctttttgt gataaatgaa tggttaagaa aataattcat
    21181 ccacagttgt atcaaacaat cttgccaact taaatgctaa tgtcaatgta ggatcatatt
    21241 tattgttttc tattgcatta atagtttgcc tagacacttt taattcttta cttaaagttt
    21301 cttgagaaat tcctttttgt tttctatatt ctctaattct atttttcatt aatttaacct
    21361 ttagatgtat attttttatt tgtagtatag taattaaaca gcataagaaa tagtgctaca
    21421 attataaaga aaatttctgg atattgagaa aaccaagatc cttcaatact tggtgacaaa
    21481 cctgtaaatt taagcactag tgtaaataac atacaatata caatccaaat aaaactttta
    21541 gccagtattt caataaacat tttacgttgt ctttcatcgt atcgatcttg ttgtcctttt
    21601 ttatctaatg tttctgaagg taaatatttg ttagttatag ccgtccataa acaagaaaaa
    21661 attaaaataa taataaaagg aattaaattc attataacac ctcataaatg taaaaagtat
    21721 ttgacattta tgagtgtaaa tatttttgat acaaatgtca aatacttttt acattataat
    21781 atattttaaa acaccttatt agtaaaacaa ttactatata gaaagctgcg aactcgtact
    21841 cttttttctt gtataattat taaaatctca attcaataat atgttatgga atttgagaca
    21901 ctgtgagaga cgctcatttg cattgacaat caatttatca agataatccc ttatcatgtt
    21961 taattctata aactgtttgt cttgtgatat taacttcttt cgcaatctta ctaatcgctt
    22021 tgccttcttc taacatttcc accacgcgat gataaataac acgtttctgt gggtctttag
    22081 catttggtga ataaagtaaa gggcgccctt tatatacgcc tttttccttc gcaacttgaa
    22141 tcccttgcgc ttgtcgacgt ttactttcat ttctctcttg ttctgaaacc attgctaata
    22201 tttgaatgat taaatctttc ataaacttat ccagtaatgg attgccaatt acttcattca
    22261 tcataggtaa gctggtaatc attaactgaa cgtctttttc ttttaaataa ttcacagttt
    22321 caataatttc atcatagtta cgtcctaaac gatcaataga ttccacaacg aatcgatctc
    22381 ccattctgac aaaattgagt gcttcttgaa atacaggtct attttccact gactttcccg
    22441 actgtttctc tgtaaagatt ttctccacac caaacgtctt taaattatcc aattgtcttt
    22501 ctaaattttg atctatcgat gatactctcg cataacctat aatcattcat cttcactcca
    22561 taataaatat acaccctaat catacgtttt aattgttata atttcaacaa ttctttttgt
    22621 atggttaggg tgtactcaaa gtgtacatat ctataattaa aacttactaa aaataaatat
    22681 agattttttc tttgtaacag aaccgttcat ttgaaggtca tctctatcat aaatatttaa
    22741 attaactaaa aattttaatc atctgtttaa tacttatgaa atgtatttac ggtaggtatt
    22801 aaaattgatg aaatttatat aagtgctttc aatgaaaatg accgtttatt tatcctcctg
    22861 atttaaggag ttagaaattt cgaaaacgat tctttccatt tgttgcattt gttccatgtc
    22921 cagatattta atacattata gaaaaccaaa gaccatcact aattaaacgc agttttaaaa
    22981 tttcatcagg attgccttcg tctttaaaat gggcctcttt taatataagt tctactcttt
    23041 catacctaac tctttcaatg ccatcgtttc atacgccgat tctcctgatt ccatagcaaa
    23101 ctcagcgata aacattggga atactgcatt gagttctatt atatgctctt tcattcgtgg
    23161 ccatatttca cctccagctt taccgtatgc tgttataagt tgctctaatc cttcgtcgtc
    23221 gaatacacga tggtgtccta taaagtccat tgatgggtcg gagtgggttg cttcagtcca
    23281 gtctatgaga cctgtgacgt ttgcttggtt atctaccatt atatgtcctg gatgtaagtc
    23341 cccatgtatc atggtcgcat gtcgaggcca tagttcgtcg ttttctaacc attgtttcca
    23401 tctgttccat aattcatctg atacgccata agtttcttta actttattca ttcttctttg
    23461 aaagtcattt tttatttctt gtatggtttt gatatttata tgctgaacgt taatgttttc
    23521 ttctggtatg ttgtgtaaat ctacgagtgt ttcagctaat gtgttaataa agttttctgg
    23581 taatggtttg tgttcaattt cccatacata attttgtatt tctggatcta ttgtggctgc
    23641 gggtttacct gtaagttttg ggtaagcaat aaggtctttt gcatgtactt tccacttcgg
    23701 tatttcaaat gaaacattct tctgtaagaa gtctaccgtt tgtttttcgg gttttgttcg
    23761 tttataaacg tcaggtcttc ttggtagtct caaaacccat tctactccat gtttatcttt
    23821 tccaaatgca acttgaaaat caagtcccga ttcattcaat gagattgttt gaggttggat
    23881 gtgtaattga tatttttctg cacatttaat aatttcatta tgtcgagtca ttttattgga
    23941 tccttatttc tattatattt ttcttgtgaa cgtatttttt atattgatat aaatgaacct
    24001 aatattcaat ataaattagt gtatagtttt taagttatat catgaagaga ttgtcctgtt
    24061 aattcccatt ttttatctga tacatgttta acaaaccttg tatcatgtga tgtaaacaaa
    24121 atgattccag gatatttatt cataaacatt tctaatgctt ctaatgtttt aatatctaaa
    24181 aaattagttg gttcatccaa aattaacata ttcgctttcg ttgaaaataa tactgctaac
    24241 gataatttcg ttctttcccc accactcaaa acattacaag aacgatcaag tgcttcattt
    24301 aaacccaagt tatttaaaat agctctactg aatgattctg atgaatccgt ttcatccatt
    24361 aaatattgca ataatgaaac gtcacgcatg tcttcataag caagttgacg atagtatgcc
    24421 atttgcactt taggagaaca atcaattccc tctatttggt ggtaaatagc ttcaagtaaa
    24481 gttgtcttac ctacaccatt tgcacctacg agcgctatat ttttgccata tggtatttgg
    24541 aatcgtactt gtgttagcag tttttgactt cctttaacca atgttagatt ttgtgcaatg
    24601 attggataat tattatggat atcataaatt ttattttgtg ggaaattgaa ttcatgataa
    24661 ctttgtggtt tttcaacttc ttccaaatgt tccattcttt tttcaatatg cttagcttgt
    24721 ttttgagcag ccttctcaac cgtgcctttt tgttttgatg cacttaaacg atctggtgct
    24781 atacttttgt ttttttgttt tgatgatgct tgtgccattt gttgcgcttg atttcgttta
    24841 gctttactgg cttgggacaa tctttgtttt tcacttatat actgttcata ttgacgttgt
    24901 tgttctaact gttcttgttc atattgattt tgatactgtg tgtaattacc tttaaacact
    24961 cttattgtgc catcttcttg tatatcccaa attgtgtcag caatttggtc tataagtgct
    25021 ctatcatgac ttactataat taaagtacca tagtaatatt ttaaaatatt tttcagataa
    25081 tctttaccaa ttttatccaa gtgatttgta ggttcatcta aaagtaatat cggactataa
    25141 tttgatatga cattagctaa tttatatttt gctttttcac caccactcat actgtcggtt
    25201 gtatgcatag gtatatggag ttcactcatt aaactaccgt ctaacgtgtt aaaatcattt
    25261 tccacatcca tgttaagctg ttcaaaatat tgaatttcgc caaccgtttc aactgttcca
    25321 gattctggtt ttgttttttg agcaatcata tttagtaatg tggttttgcc agtaccatta
    25381 cccccaataa gtgctatttt ttcaaattgg taagcgtaaa gatgaccgat gttaagtgat
    25441 cgtaaatctg tcaatttatg attgatttgg ttaaatttaa ttgtatattg ttccatattt
    25501 atacactcct tgtatattta aaggacgtgt acgcaaaaaa atgagacagg ctactcccgt
    25561 ctcattcaca ttacactttc aaacacttaa aaatttatta tgatgtttta gtatttgaaa
    25621 gcgtttatta ttcctatcga aggataaaaa atgacataag tcatcctatg agtgtgtatt
    25681 gcggacaagc ctttttgaat taatttagtt ttgtattcaa aaaggtttat ttgagtctca
    25741 tagaagctgt cattttaatc ctccttcatc gataaaatag taatgttaat ataacatttt
    25801 gttggttttt ttacaatata tctctaagta gaaagattat ataacaaaag tataaaaata
    25861 caattttaga ttgattatac atctccttaa tttagagtgt actcataaaa tacggttctg
    25921 ttgcaaagtt gaatttataa tataatttta acaaaaagga gtcttctgta tgaactattt
    25981 cagatataaa caatttaaca aggatgttat cactgtagcc gttggctact atctaagata
    26041 tgcattgagc tatcgtgata tatctgaaat attaagagaa cgtggtgtaa acgttcatca
    26101 ttcaacgatc taccgttggg ttcaagaata tgccccaatt ttatatcaaa tttggaagaa
    26161 aaagcataaa aaagcttatt acaaatggcg tattgatgag acgtatatca aaataaaagg
    26221 aaaatggagc tatttatatc gtgccattga tacagaggga catacattag atatttggtt
    26281 gcgtaagcaa cgagataatc attcagcata tgcgtttatc aaacgtctca ttaaacaatt
    26341 tggtaagcct caaaaggtag ttacagatca ggcaccttca acgaaggcag caatggctaa
    26401 aataattaaa gcttttaaac ttaaacctga ctgtcattgt acatcgaaat atctgaataa
    26461 cctcattgag caagatcacc gtcatattaa agtaagaaag acaagatatc aaagtatcaa
    26521 tacggcaaag aatactttaa aaggtattga atgtatttac gctctatata aaaagaaccg
    26581 taggtctctt cagatctacg gattttcccc atgccacgaa attagcatca tgctagcaag
    26641 ttaaacgaac actgacatga tatattagtg attagctata ttttttactt tgcaacagaa
    26701 ccagccattt aatatgactg ttacaattac taagattcaa gcactattac gccgcacgta
    26761 tgatttcacc actcaagtta ataatttaac agtagatgat tgcgagttac tacttgatgc
    26821 agcaaagctt aaatttaatg aagaaaccat agacctgaca cacactgaat tgcaaatcat
    26881 gcatagctta ttccagaaca agggcaaatt cgtcagtcgt aatgcgttaa tcgaaaaatg
    26941 ctgggaatca gaacacttca ttgatgacaa tacgcttgct gtcaacatta cacgtttacg
    27001 caaaaagcta caaaaactag gacttacaga ttttatcgaa acgaagaaaa atgtcggata
    27061 tcgtgta
//
