LOCUS       NZ_CP014373            25980 bp    DNA     circular CON 08-MAY-2024
DEFINITION  Staphylococcus aureus strain USA300-SUR4 plasmid pUSA04-2-SUR4,
            complete sequence.
ACCESSION   NZ_CP014373
VERSION     NZ_CP014373.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN04497598
            Assembly: GCF_003595425.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 25980)
  AUTHORS   Sabat,A.J., Hermelijn,S.M., Akkerboom,V., Juliana,A., Degener,J.E.,
            Grundmann,H. and Friedrich,A.W.
  TITLE     Complete-genome sequencing elucidates outbreak dynamics of CA-MRSA
            USA300 (ST8-spa t008) in an academic hospital of Paramaribo,
            Republic of Suriname
  JOURNAL   Sci Rep 7, 41050 (2017)
   PUBMED   28106148
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25980)
  AUTHORS   Sabat,A.J., Hermelijn,S., Akkerboom,V., Degener,J.E., Grundmann,H.
            and Friedrich,A.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-FEB-2016) Medical Microbiology, University Medical
            Center Groningen, Hanzeplein 1, Groningen 9700 RB, The Netherlands
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SeqMan NGen v. 12.1.0
            Genome Coverage                   :: missing
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003595425.1-RS_2024_05_07
            Annotation Date                   :: 05/07/2024 04:16:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,001
            CDSs (total)                      :: 2,920
            Genes (coding)                    :: 2,830
            CDSs (with protein)               :: 2,830
            Genes (RNA)                       :: 81
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 51 of 90
            Pseudo Genes (incomplete)         :: 42 of 90
            Pseudo Genes (internal stop)      :: 18 of 90
            Pseudo Genes (multiple problems)  :: 20 of 90
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP014373.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..25980
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="USA300-SUR4"
                     /isolation_source="Urine"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pUSA04-2-SUR4"
                     /geo_loc_name="Suriname: Paramaribo"
                     /lat_lon="5.866667 N 55.166667 W"
                     /collection_date="2013-04-25"
                     /collected_by="Sandra Hermelijn"
     gene            join(25771..25980,1..465)
                     /locus_tag="AYM16_RS15465"
                     /old_locus_tag="AYM16_15095"
     CDS             join(25771..25980,1..465)
                     /locus_tag="AYM16_RS15465"
                     /old_locus_tag="AYM16_15095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105956.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            <606..1241
                     /locus_tag="AYM16_RS15470"
                     /pseudo=""
     CDS             <606..1241
                     /locus_tag="AYM16_RS15470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009251744.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /name="aminoglycoside 6-adenylyltransferase"
     gene            1238..1768
                     /gene="sat4"
                     /locus_tag="AYM16_RS15475"
                     /old_locus_tag="AYM16_15110"
     ARG             1239..1765
                     /name="sat4"
                     /gene="sat4"
                     /gene_name="streptothricin N-acetyltransferase Sat4"
                     /tool="amrfinderplus"
                     /drug_class="STREPTOTHRICIN"
                     /identity="97.78"
                     /coverage="100.0"
     gene            1861..2655
                     /gene="aph(3')-IIIa"
                     /locus_tag="AYM16_RS15480"
                     /old_locus_tag="AYM16_15115"
     ARG             1862..2652
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            2931..>3247
                     /locus_tag="AYM16_RS15490"
                     /old_locus_tag="AYM16_15120"
                     /pseudo=""
     CDS             2931..>3247
                     /locus_tag="AYM16_RS15490"
                     /old_locus_tag="AYM16_15120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001079940.1"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /name="HTH domain-containing protein"
     gene            complement(3307..3981)
                     /locus_tag="AYM16_RS15495"
                     /old_locus_tag="AYM16_15125"
     CDS             complement(3307..3981)
                     /locus_tag="AYM16_RS15495"
                     /old_locus_tag="AYM16_15125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105991.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            4243..4428
                     /locus_tag="AYM16_RS15715"
                     /old_locus_tag="AYM16_15130"
     CDS             4243..4428
                     /locus_tag="AYM16_RS15715"
                     /old_locus_tag="AYM16_15130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001037130.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            complement(4651..5229)
                     /locus_tag="AYM16_RS15500"
                     /old_locus_tag="AYM16_15135"
     CDS             complement(4651..5229)
                     /locus_tag="AYM16_RS15500"
                     /old_locus_tag="AYM16_15135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690637.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(5493..5873)
                     /gene="blaI"
                     /locus_tag="AYM16_RS15505"
                     /old_locus_tag="AYM16_15140"
     ARG             complement(5497..5873)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.41"
                     /coverage="100.0"
     gene            complement(5863..7620)
                     /gene="blaR1"
                     /locus_tag="AYM16_RS15510"
                     /old_locus_tag="AYM16_15145"
     ARG             complement(5867..7620)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.38"
                     /coverage="100.0"
     gene            7727..8572
                     /gene="blaZ"
                     /locus_tag="AYM16_RS15515"
                     /old_locus_tag="AYM16_15150"
     ARG             7728..8569
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(9098..9517)
                     /locus_tag="AYM16_RS15525"
                     /old_locus_tag="AYM16_15155"
     CDS             complement(9098..9517)
                     /locus_tag="AYM16_RS15525"
                     /old_locus_tag="AYM16_15155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418034.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_000418035.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            9641..10612
                     /locus_tag="AYM16_RS15530"
                     /old_locus_tag="AYM16_15160"
     CDS             9641..10612
                     /locus_tag="AYM16_RS15530"
                     /old_locus_tag="AYM16_15160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="WP_000481279.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(10784..10876)
                     /locus_tag="AYM16_RS15535"
     CDS             complement(10784..10876)
                     /locus_tag="AYM16_RS15535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001791613.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(11033..11380)
                     /locus_tag="AYM16_RS15540"
                     /old_locus_tag="AYM16_15165"
     CDS             complement(11033..11380)
                     /locus_tag="AYM16_RS15540"
                     /old_locus_tag="AYM16_15165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000119690.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(11399..12016)
                     /gene="cadD"
                     /locus_tag="AYM16_RS15545"
                     /old_locus_tag="AYM16_15170"
     ARG             complement(11403..12016)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            12910..13206
                     /locus_tag="AYM16_RS15550"
                     /old_locus_tag="AYM16_15175"
     CDS             12910..13206
                     /locus_tag="AYM16_RS15550"
                     /old_locus_tag="AYM16_15175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002311824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002311824.1"
                     /translation="MQIGVLKWLQFTKQKGVHFPMQFLEPKNKNAKSVDWEISEQVRVI
                     VKQYAEYAERTESEAVDEFLLNILDDKKFIEWIANKRSNKRIVEKMGIKDRVG"
                     /name="hypothetical protein"
     gene            13213..15165
                     /locus_tag="AYM16_RS15555"
                     /old_locus_tag="AYM16_15180"
     CDS             13213..15165
                     /locus_tag="AYM16_RS15555"
                     /old_locus_tag="AYM16_15180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017431446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000163792.1"
                     /translation="MTKLKRLATKEDEIVDVKIPISNEELKDRAKQYDLLTPKRFATRY
                     NKMLFLPTSFKWNGSEYPIQYNYCINPFCCNFGKEQHKFKDVKGKPSRYKMTGSSKDKG
                     HKGMYCNDNPIGRGVSQNCTVTPLSNWSVVEEIKRLIEINSIQDVEPDYQFHKEGCSEE
                     ESTPFNEPKQFYKRGKSRGKSQRYQCKACKKFTNVLPKREETTTYHQQKNTILPMFAKM
                     VVGRVSVSRTCDILGIGVGTYYHKLEWLYRRCLEFLERYETQPLQTKKFNEMWLNTDKM
                     HYYLNNVRKKGQGSKKYTGFEDLNMQTYIVVSAEVLSRYVFRSDVAYDWNISMDELNED
                     TRKFKEDHLNTFSRKNDRLDWSYYPQEPSANDSENRNAYLHELGKITNRSRFVDGLNVD
                     APYTTTAHYWLIKQMVNADEWRMISDDDFSIRNAFYRVFTKELRLSDAHHFICQVNKTK
                     SRKQCLKEFGQAKAELLDWGDIRGFKTKFLRTLASHYLTELLTSHQFHEEAISKDGERY
                     RKYADNPIKHPLATKDKGFYSVDCRTDLSALEPNEIAKMLLNVNDHSTNSFIQQIRRYI
                     SSLERPLTTARGDKKSYIYANFNPKYAQFAITILRTYYNFCRPFKSADKKVLTPAQRLG
                     ITDKQFDWKDIIYFK"
                     /name="hypothetical protein"
     gene            complement(15237..15734)
                     /gene="dfrG"
                     /locus_tag="AYM16_RS15560"
                     /old_locus_tag="AYM16_15185"
     ARG             complement(15241..15734)
                     /name="dfrG"
                     /gene="dfrG"
                     /gene_name="trimethoprim-resistant dihydrofolate reductase
                     DfrG"
                     /tool="amrfinderplus"
                     /drug_class="TRIMETHOPRIM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(16417..16611)
                     /locus_tag="AYM16_RS15570"
                     /old_locus_tag="AYM16_15190"
     CDS             complement(16417..16611)
                     /locus_tag="AYM16_RS15570"
                     /old_locus_tag="AYM16_15190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001004925.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            16721..17413
                     /locus_tag="AYM16_RS15575"
                     /old_locus_tag="AYM16_15195"
     CDS             16721..17413
                     /locus_tag="AYM16_RS15575"
                     /old_locus_tag="AYM16_15195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative immunity/bacteriocin fusion bifunctional
                     protein"
                     /protein_id="WP_000691527.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="putative immunity/bacteriocin fusion bifunctional
                     protein"
     gene            complement(17581..17730)
                     /locus_tag="AYM16_RS15825"
     CDS             complement(17581..17730)
                     /locus_tag="AYM16_RS15825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000695366.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(18277..>18566)
                     /locus_tag="AYM16_RS15580"
                     /pseudo=""
     CDS             complement(18277..>18566)
                     /locus_tag="AYM16_RS15580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009384749.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(18586..19569)
                     /locus_tag="AYM16_RS15585"
                     /old_locus_tag="AYM16_15200"
     CDS             complement(18586..19569)
                     /locus_tag="AYM16_RS15585"
                     /old_locus_tag="AYM16_15200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_001181107.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFENRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            19995..20738
                     /locus_tag="AYM16_RS15590"
                     /old_locus_tag="AYM16_15205"
     CDS             19995..20738
                     /locus_tag="AYM16_RS15590"
                     /old_locus_tag="AYM16_15205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_000843732.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(20965..21150)
                     /locus_tag="AYM16_RS15595"
                     /old_locus_tag="AYM16_15210"
     CDS             complement(20965..21150)
                     /locus_tag="AYM16_RS15595"
                     /old_locus_tag="AYM16_15210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276570.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000797248.1"
                     /translation="MKNRIREYRKQKGISQETLSKELKVSRQTINAIENNKYDPTLTLA
                     FKLARLFDTTVDELFS"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(21155..21493)
                     /locus_tag="AYM16_RS15600"
                     /old_locus_tag="AYM16_15215"
     CDS             complement(21155..21493)
                     /locus_tag="AYM16_RS15600"
                     /old_locus_tag="AYM16_15215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001049146.1"
                     /translation="MNLIPFIIILIFSCLWTAITNKYLPSETLDKKGQQDRYDERQRKM
                     FIEILAKSFIWIVYCMLFTLVLKFTGLSPSIEGSWFSQYPEIFFIIVALFLMLFNYYTT
                     NKKYTSKG"
                     /name="hypothetical protein"
     gene            complement(21739..22347)
                     /locus_tag="AYM16_RS15605"
                     /old_locus_tag="AYM16_15220"
     CDS             complement(21739..22347)
                     /locus_tag="AYM16_RS15605"
                     /old_locus_tag="AYM16_15220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000583528.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTFGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKDVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGKAISKIAKEVNITRQTVYRIKHDKGLS"
                     /name="recombinase family protein"
     gene            complement(22833..23732)
                     /locus_tag="AYM16_RS15610"
                     /old_locus_tag="AYM16_15225"
     CDS             complement(22833..23732)
                     /locus_tag="AYM16_RS15610"
                     /old_locus_tag="AYM16_15225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000196697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mph(C) family macrolide 2'-phosphotransferase"
                     /protein_id="WP_000196697.1"
                     /translation="MTRHNEIIKCAEKYQLHIQPQTISLNESGLDFQVAFGKDKHGVEW
                     VLRLPRRPDVYKRTKPEKQTVDFLQKNVSFEIPKWKVHAKDLIAYPKLTGKPAATIDPE
                     IQNYVWEIEHKPLPENFINTLAETLVDLHNIPEENINVQHINIKTIQEIKNDFQRRMNK
                     VKETYGVSDELWNRWKQWLENDELWPRHATMIHGDLHPGHIMVDNQANVTGLIDWTEAT
                     HSDPSMDFIGHHRVFDDEGLEQLITAYGKAGGEIWPRMKEHIIELNAVFPMFIAEFAME
                     SGESAYETMALKELGMKE"
                     /name="Mph(C) family macrolide 2'-phosphotransferase"
     gene            complement(23831..25297)
                     /gene="msr(A)"
                     /locus_tag="AYM16_RS15615"
                     /old_locus_tag="AYM16_15230"
     ARG             complement(23835..25297)
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(22837..23732)
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(23832..25297)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             complement(22834..23732)
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             1251..1768
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="97.16"
                     /coverage="95.56"
     ARG             7728..8572
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     ARG             643..944
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.0"
                     /coverage="36.23"
     Typing          complement(18074..18221)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          complement(18280..18455)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="92.697"
                     /coverage="94.0"
                     /evalue="1.04e-65"
     Typing          complement(18587..19569)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.593"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          19996..20738
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 tacaaatggc gtattgatga gacgtatatc aaaataaaag gaaaatggag ctatttatat
       61 cgtgccattg atacagaggg acatacatta gatatttggt tgcgtaagca acgagataat
      121 cattcagcat atgcgtttat caaacgtctc attaaacaat ttggtaaacc tcaaaaggta
      181 attacagatc aggcaccttc aacgaaggta gcaatggtta aagtaattaa agcttttaaa
      241 cttaaacctg actgccattg tacatcgaaa tatctgaata acctcattga gcaagatcac
      301 cgtcatatta aagtaagaaa gacaaggtat caaagtatca atacagcaaa gaatacttta
      361 aaaggtattg agtgtattta cgctctatat aaaaagaacc gcaggtctct tcagatctac
      421 ggattttcgc catgccacga aattagcatc atgctagcaa gttaaacgaa cactgacatg
      481 atatattagt gattagctat attttttact ttgcaacaga accatcattt ttattaaaat
      541 actcttttgt aaaatctttc tgctcttcaa tgtatttaat ttctttacct ctaaatctat
      601 tatagctatt tgatgattac aataaaattg atcttacctt attgcccttg gaagagttag
      661 ataattacct aaagggcgat aaattaataa aggttctaat tgataaagat tgtagaatta
      721 aaagggacat agttccgact gatatagatt atcatgtaag aaagccaagc gcaagggagt
      781 atgatgattg ctgcaatgaa ttttggaatg taacacctta tgttattaaa ggattgtgcc
      841 gtaaggaaat tttatttgct attgatcatt ttaatcagat tgttcgccat gagctgctga
      901 gaatgatatc atggaaggtc ggcatcgaaa caggctttaa atgaagtgta ggcaagaact
      961 ataagtttat tgaaaggtat atatccgagg atttgtggga gaaacttttg tccacctacc
     1021 ggatggattc ctatgaaaac atatgggaag cattatttct atgccatcaa ttgttcaggg
     1081 cggtatccgg tgaggtggcg gaaaggcttc attatgccta tccggagtat gataggaata
     1141 taacaaaata taccagggac atgtataaaa aatacactgg taaaaccggc tgcctggata
     1201 gcacatatgc cgctgatata gaagagaggc gggaacagtg attacagaaa tgaaagcagg
     1261 gcacctgaaa gatatcgata aacccagcga accatttgag gtgataggta agattatacc
     1321 gaggtatgaa aacgagaatt ggacctttac agaattactc tatgaagcgc catatttaaa
     1381 aagctaccaa gacgaagagg atgaagagga tgaggaggca gattgccttg aatatattga
     1441 caatactgat aagataatat atctttacta ccaagacgat aaatgcgtcg gaaaagttaa
     1501 actgcgaaaa aattggaacc ggtacgctta tatagaagat atcgccgtat gtaaggattt
     1561 cagggggcaa ggcataggca gcgcgcttat caatatatct atagaatggg caaagcataa
     1621 aaacttgcat ggactaatgc ttgaaaccca ggacaataac cttatagctt gtaaattcta
     1681 tcataattgt ggtttcaaaa tcggctccgt cgatactatg ttatacgcca actttgaaaa
     1741 agctgttttc tggtatttaa ggttttagaa tgcaaggaac agtgaattgg agttcgtctt
     1801 gttataatta gcttcttggg gtatctttaa atactgtaga aaagaggaag gaaataataa
     1861 atggctaaaa tgagaatatc accggaattg aaaaaactga tcgaaaaata ccgctgcgta
     1921 aaagatacgg aaggaatgtc tcctgctaag gtatataagc tggtgggaga aaatgaaaac
     1981 ctatatttaa aaatgacgga cagccggtat aaagggacca cctatgatgt ggaacgggaa
     2041 aaggacatga tgctatggct ggaaggaaag ctgcctgttc caaaggtcct gcactttgaa
     2101 cggcatgatg gctggagcaa tctgctcatg agtgaggccg atggcgtcct ttgctcggaa
     2161 gagtatgaag atgaacaaag ccctgaaaag attatcgagc tgtatgcgga gtgcatcagg
     2221 ctctttcact ccatcgacat atcggattgt ccctatacga atagcttaga cagccgctta
     2281 gccgaattgg attacttact gaataacgat ctggccgatg tggattgcga aaactgggaa
     2341 gaagacactc catttaaaga tccgcgcgag ctgtatgatt ttttaaagac ggaaaagccc
     2401 gaagaggaac ttgtcttttc ccacggcgac ctgggagaca gcaacatctt tgtgaaagat
     2461 ggcaaagtaa gtggctttat tgatcttggg agaagcggca gggcggacaa gtggtatgac
     2521 attgccttct gcgtccggtc gatcagggag gatatcgggg aagaacagta tgtcgagcta
     2581 ttttttgact tactggggat caagcctgat tgggagaaaa taaaatatta tattttactg
     2641 gatgaattgt tttagtacct agatttagat gtctaaaaag ctttaactac aagcttttta
     2701 gacatctaat cttttctgaa gtacatccgc aactgtccat actctgatgt tttatatctt
     2761 ttctaaaagt tcgctagata gagttctata ttagagatgt aaagagtttt ggtgaagagg
     2821 tttgtgagta tggcttttat aaccagggtg caatgagaag cactaacagc agctagctta
     2881 agaacgcata ggatatactt tttatggaag tcacagagga ggaataaaat ttgaacagga
     2941 ttaacagagt aacctctatt cttattcagc tgcaatcaaa aaaataattc ctgccaaaga
     3001 aattgcacag cgatttaata taagcttaag gacagtttac agagatatcc ggacacttga
     3061 agaagccgga ataccaattg gatctgaggc cggaaaagga tattttcttg tagagggctt
     3121 cctacttctg ccggtaatgt ttacagcggc ggaagtgggt gcattgatta cagcagggaa
     3181 atttttaaat tgccatggag atgaatcatt tataaaggat tttgattcag ctatgtataa
     3241 aatcaaaggt tctgttgcaa agtaaaaaaa tatagctaac cactaattta tcatgtcagt
     3301 gttcgcttaa cttgctagca tgatgctaat ttcgtggcat ggcgaaaatc cgtagatctg
     3361 aagagacctg cggttctttt tatatagagc gtaaatacac tcaatacctt ttaaagtatt
     3421 ctttgctgta ttgatacttt gataccttgt ctttcttact ttaatatgac ggtgatcttg
     3481 ctcaatgagg ttattcagat atttcgatgt acaatggcag tcaggtttaa gtttaaaagc
     3541 tttaattact ttaaccattg ctaccttcgt tgaaggtgcc tgatctgtaa ttaccttttg
     3601 aggtttacca aattgtttaa tgagacgttt gataaacgca tatgctgaat gattatctcg
     3661 ttgcttacgc aaccaaatat ctaatgtatg tccctctgca tcaatggcac gatataaata
     3721 gctccatttt ccttttattt tgatgtacgt ctcatcaata cgccatttgt aataagcttt
     3781 tttatgcttt ttcttccaaa tttgatataa aattggggca tattcttgaa cccaacggta
     3841 gaccgttgaa tgatgaacgt ttacaccacg ttcccttaat atttcagata tatcacgata
     3901 actcaatgca tatcttagat agtagccaac agctacagtg ataacatcct tgttaaattg
     3961 tttatatctg aaatagttca tacagaagac tcctttttgt taaaattata ctataaattc
     4021 aactttgcaa cagaacctca tttactatat gggcatctct ttcattatta atacaaagct
     4081 ttgtatctcc gatattaggc aaaggtgtaa acgaattagg tgatactata ggattcaaca
     4141 ttatattaat cgtttcttta ataatgatta tcttcttatt ttttataaat cgtagtaaaa
     4201 atatctccta tgattatata aaagttcaaa gaggtgaagc caatgaataa attagaaaaa
     4261 tggtctttgg tatttattat ttttacattt ctctcttcat tagcactttt atatttcaaa
     4321 tataatttta gttcggttat gccagtccta agtctttcta ttttaactat actaatattg
     4381 ttgacgagta ttattactgt agtttcagtt aatgatgaag atacttaaaa cgttcattag
     4441 tgaaacaggt attatattaa aaaagcgtac gaatttgtac gcttttttct tgtgttatta
     4501 ttaaaatctc ataacaggaa aatattatga gattttagac gctgtcagaa cgtctctttt
     4561 acatcgagtg acattgaatc aaagtctttg tatgttaatg atatataaaa ttatttagta
     4621 gattcattat agtaagctag attagttgct ctacttgttt ttattctctt ttgcctctaa
     4681 tttattgaga taacgataaa tagttgtacg tgaaacttgc cactgctctg caattgtttt
     4741 aattggcgta ccattatcat aaagtgtctt aagtaagttt aaatcttgtt tatttaattt
     4801 ttcaggtcta cctccatatc ggcctctagc acgtgctgca attcgaccgg ctgatgatcg
     4861 ctctaaaatt aaattacgtt caaactctgc aaatgctgcg aataaatgaa ataataattg
     4921 tcctgtagaa cttgatttat ccatcgttat attttcttct aaactatgaa aactcacacc
     4981 tcgttcgtta agttcattaa ctaacgtgat taaatcctcc atgttccgtc ctagtctatc
     5041 taatctccaa acaacaatcg tatctcctga cctcgcaaat tcaattgctt tatctaaacc
     5101 aggtcgctta ctttttgaac cactcatatg gtcattaaat atcttttcac aaccatatgt
     5161 atttaatcga tcctcctgta aattcaaatt ttgtaatcca gttgaaactc ttgcataacc
     5221 tattttcaaa atacagacct cctatataca cctttagtgt accataactt gattacgagg
     5281 tcttttgtga acatagattt tttgttgggt ttttgaacac ataattctat gtaatactta
     5341 cttatttaga caaaaaacaa gagtgtacag aaaatggtta ttttctggac actctcatct
     5401 ttaataatat attttaaatg tcattaacaa aactaattta ataagagtca agtatggttt
     5461 acatatgtat tatgtttgaa acatacctct aattactttt tactaatatc atttaaaatg
     5521 tctcgcaatt cttcaatttc tttgttattt aattcttcat ttttcgcaaa attcagcact
     5581 aaacttttca tatcccctcc atacagttta ttaagaaagg ttttagcagt tttcatttta
     5641 atatcgtctt ctttaatatt tgatgagtaa aaataaatat tttctgattt gtatcgtttt
     5701 ataatctctt ttttatatag tcttgtgatt aatgttctaa tcgttttatc actaacttct
     5761 ttatattttt gaatttcaac tacaatttca ttagctgata ctgatttttt atcccatatt
     5821 atattcataa catcccattc agccatagat atttcaactt gcttattggt catttaaaac
     5881 acccattcct tttaatattt tttcacttat taattcagca tttttcccag acgggtttcc
     5941 atctgataaa tgtgtagcaa aataatactt atcatgattt gtaattacgt aacctacaaa
     6001 ccacccatta ttatacttcc cgtttactat acctgtacct gttttcccat acagttcata
     6061 cttttcattt ttcttaatca ataatgaaga agataattga ttctttgctt ttttactaaa
     6121 atggttattt tgttccatca tatttttaaa aactattact tgttcaagat tagatatttt
     6181 caaactatct tccatccaat agcttttata acttcccaaa ttttcattac cataatttaa
     6241 ttgcttgagt tgagccgcag tatagttctt tggtatttga ttactaatac gttcgaagta
     6301 ccaattaact gaattttgca ttgctgtatt taaatcttgt tccttattcc aagactcgaa
     6361 aagataatgt ttatgattcc atgacatacg tgaattttta tcacttataa tatgacggtc
     6421 aagtccaaac agtgctaaat aaattttgta agttgaatca ggagaatatc tttttctact
     6481 ttctttttca ttataaatat agtatttgtc tttcttcatg ctgtacataa cgaaagatcc
     6541 actatttgaa ccaaaatttt tactttcatc taaaatttgg taatcgcttt gtaagggctt
     6601 tttataatta taatcagtta aggattgccc cattaaaaac tggctttgaa ttatcatgat
     6661 aaaaaaagta aaaatacaaa taaaaattag aattaatttt gactgctttt tcagatcggc
     6721 ttcttttata ttaattaatc tacttttgag taatgatttt ttaccattaa atgaatggct
     6781 taatatattt ttgttggaaa atggggtttt taatacggag tccataatag attccgcata
     6841 agttttaaat tcatttttgt taatattatt aaggacaaat ctatcggctt ctacttcatt
     6901 gtcatgaatt atctttcttt ttacaatatg tactaatgga ttgtaactca taataataga
     6961 gaagatatta aagataatta aatgtaaagt atctctattt ttagcatgag catattcatg
     7021 cagtattata tattttagtc ttttatcaat tacactttta aaatatgaac taggaatcaa
     7081 aataatatat ttcccatacc aaaaagttat tggagattga atagcctctg cttttcgaat
     7141 cacaatattt tttttatatt gatggttgaa aagtatcgta tctattttat ttttttcatt
     7201 ttcgtttaga taaagtgact gtttctttaa atatttaaga tataataagg ctttcaaaaa
     7261 tttaaaactt aaaataataa ctaaaactat ccaaataact gtgcagatat tatcaattga
     7321 atcccaatta aacttatgga tatctgttgt gaactcttga ataggtttgg tggtatttat
     7381 gttatggttc aaatcgtgtg acttactttc aactgtgggc gcttgattat tcacattatt
     7441 aaattttata aaagagaatt taattgggat aaaaggaatt aatccagcaa gcatagttag
     7501 ataccaaact ttataattta aactataatt aaaatagcgt tttaatatgt acctaaaaaa
     7561 tactaacaat agaaatataa aacaaaagct tactacgctc attattagta atttagccat
     7621 tttgacacct tctttcaaat atttataata aacaattgac atcaatatta caattgtaat
     7681 attattgatt tataaaaatt acaactgtaa tatcggaggg tttattttga aaaagttaat
     7741 atttttaatt gtaattgctt tagttttaag tgcatgtaat tcaaacagtt cacatgccaa
     7801 agagttaaat gatttagaaa aaaaatataa tgctcatatt ggtgtttatg ctttaaatac
     7861 taaaagtggt aaggaagtaa aatttaattc agataagaga tttgcctatg cttcgacttc
     7921 aaaagcgata aatagtgcta ttttgttaga acaagtacct tataataagt taaataaaaa
     7981 agtacatatt aacaaagatg atatagttgc ttattctcct attttagaaa aatatgtagg
     8041 aaaagatatc actttaaaag aacttattga ggcttcaatg acatatagtg ataatacagc
     8101 aaacaataaa attataaaag aaatcggtgg aatcaaaaaa gttaaacaac gtctaaaaga
     8161 actaggagat aaagtaacaa atccagttag atatgagata gaattaaatt actattcacc
     8221 aaagagcaaa aaagatactt caacgcctgc tgctttcggc aagactttaa ataaacttat
     8281 cgcaaatgga aaattaagca aaaaaaataa aaatttctta cttgatttaa tgtttaataa
     8341 taaaaacgga gacactttaa ttaaagatgg tgttccaaaa gactataagg ttgctgataa
     8401 aagtggtcaa gcaataacat atgcttctag aaatgatgtt gcttttgttt atcctaaggg
     8461 ccaatctgaa cctattgttt tagtcatttt tacgaataaa gacaataaaa gtgataagcc
     8521 aaatgataag ttgataagtg aaaccgccaa gagtgtaatg aaggaatttt aatattctaa
     8581 atgcataata aatactgata acatcttata gtttgtatta tattttgtat tatcgttgac
     8641 atgtataatt ttgatatcaa aaactgattt tccctttatt attttcgaga tttattttct
     8701 taattctctt taacaaacta gaaatattgt atatacaaaa aatcataaat aatagatgaa
     8761 tagtttaatt ataggtgttc atcaatcgaa aaagcaacgt atcttattta aagtgcgttg
     8821 cttttttctc atttataagg ttaaataatt ctcatatatc aagcaaagtg acaatagcat
     8881 tttacaagta ttttttattg ttcgattagg gtaaacctaa ataatacata aattatatta
     8941 caatatgttt attatagagg ctaaagtatc ttagaaattt ggatagtagg tttttcggga
     9001 ataaaagtat agttggcttt aatatataat taagctaagc tatcatttat atttactcga
     9061 ttataattcg cacttcaact tttttataac gtaaaaatta aaacgtagtt ttatttatct
     9121 ttagtaatat ctttttaaac actacagttt cttcattagt taaattagcg aagtaatgat
     9181 tattaagttg ataggctttc ttttctaatg ttggccataa gtcttttgct ttatttgtac
     9241 tgtttattag cacagttctt ctattttcat tatcagtttg acgtgttatt agatcctttt
     9301 tggacatctt atctaatatt ccagatattg ttgaaggttc taaatttaaa gtattaccaa
     9361 tcgctttagg tgtattcaaa ttactattaa tcaagcaatt caaaacacca tattctgctg
     9421 gagtaatatt atagggactt aataaacttt taaaatgttt aaaaactcta ttctgagaag
     9481 tactcaacaa ataatttata caattatcta attccacaac taaaacctct cttaaatcat
     9541 tagtattgac tcgcttatca tatcatgata agttttgtag gaaaatagtt ttgcaacaaa
     9601 aacatacttc tacaaaacaa ttgtgaaaga aggctaataa atgttcaatg cggtagtagt
     9661 gagaaaaagt gcatcaaatg ttagttataa agtagaaaaa gttgatgaat ctcatttatc
     9721 gaagggtgat gtattagtaa aagtggtata ctcttcaata aattataagg atatgctagc
     9781 tttacaatat aaaggcggtg taattagaga ttatcctatg attcctggta tagattttgc
     9841 aggtattgtt gaatcaagtt cgaatgataa gtttaaagaa ggcgataatg tattagttac
     9901 tggttatgat gttggcgtga cacatacagg tggattttca gaatatgcac aagtgcctgg
     9961 agagtggatt gttcctattc cccaagaaat gtctattaaa gagtctatgg tatatggcac
    10021 agccggtttt acggcagcat tatcaatttt tgaactagaa aaatatggaa tgaatatcaa
    10081 atcacaacct gaaattttag tgtctggggc tacaggtggt gtgggcagtg ttgctataca
    10141 aattttacat aaaattggat atgaaaatat cactgctatc gtaagaaaag aaaagcaaat
    10201 agaaatcgca aaaaaattag gtgcaaaaca agtaataata attgaagatg ataataaacc
    10261 gcttaaaaaa ggtatttttg attatttctt agatacagtg gggagtaatg taacattata
    10321 cggtttaaaa cgtctaaatt atcaaggtgt tgctactgta tgtggaaatg tagcaggaaa
    10381 ttcacttaac gctaatatat taccgtttat tcttagaggt attaaattaa ttggcattga
    10441 ttctgtatat gttgatcata atatccgtga agatatatgg agtaagttag caaatgaatg
    10501 gaatatagga aattcacttc tatacaatga aattggattt gaagaattct ataaaacgat
    10561 agatcagctt ttaaaaggac aacatttagg aagaactatt ttaaaagtat aagtgtgagt
    10621 attcattaat acatttacta ttaattcaat cattttgcat ttctctacta accagtgtta
    10681 taatttatat aacgaaaatg attaacaatt aatgcaccaa tccccacact attgcagtag
    10741 tgtggggatt ttttcgatgc tggcttataa agtcgcctat taattatttg ttgcgtttac
    10801 taagccaata agtataatac gcaacagcac agccactgat gactggtgct atgatgtgaa
    10861 cgaaaatgat tagcaaagta atgcacctcc tctcttcgtc aattgacgcc tgagagatag
    10921 gcgactctat tattatacca tctgtgaata tacaagcata tctacttccg ataagtcgtc
    10981 ttatgttata taactttgtt ttttatagta tcaagacaag aagaaactcg tttcaaaaac
    11041 cctcatgatt tttagagaaa aactctctta tttcatcgtc tttaataaaa taatatgcca
    11101 tctttccatc tttataaaaa tcaagtacct catttttata taaaagcctt aaatgatgtg
    11161 aagttgaagc aacactcatt ttcaatatca aagaaatatc acaaacacac aactcatctt
    11221 ctttaatcaa agataatatg attttcaatt tcttctcatc acaaattttt tctaaaatgt
    11281 taagtaattt cttagattta tcatcttcta aaaaacttaa agcattgtta actttatcct
    11341 catgtacaca gatcacatca caagtatttt cataactcat ataaaatcac accctaaatt
    11401 aaaatataaa tcctaaaatt gtttgaatag tgtcattttc aataataata aataaaccta
    11461 aagctatata aataatagcc ataatccaac gactaaattt ctcaacaatt tctccaattc
    11521 ctggaatatt agctaatttt tgtgcagtaa acaccaagaa gaaaattaaa attaaaaaga
    11581 caaacagagt aagtaataaa ttagtaacac ttaatgtcac aaaatacgga acaaataaac
    11641 caatattatc ggcgccacaa cttgctatcg taacaattgc aaccgtacca actaatttag
    11701 acaatccttt ttcattcaat tcttttttag ctctcttttc tccttcacaa tcatcataaa
    11761 tagccacttt aattccaaga taaattggta ttaaacccaa taaacctaat atccactttt
    11821 ctggaacata atttaataca aaagctaaaa acaaactaac taatattaaa ataatagacc
    11881 ctaaatattg accaacataa atatctctat attcttttct agtctttgct ctagcaaaaa
    11941 atattaataa aattactaat aaatcaactg ctgtagcaat ataaagaaca gcagcagcaa
    12001 caaccgtttg aatcataata cacctcattc aaaaatattt ttgaatgtat tataacttat
    12061 atttttaaat aatcataggt gctttattcc aattgcttta ttgacgttga gcctcggaac
    12121 ccttaacaat cccaaaactt gtcgaatggt cggcttaata gctcacgcta tgccgacatt
    12181 cgtctgcaag tttagttaag ggttcttctc aacatcaata aattttttcg gcataaatgc
    12241 gtgtctatgc gtagacatgg agacacttca gaattatgga gtgattacat gagtttaact
    12301 atttttcttt attcagtttt aggaagttta ttagcaaatt atatctacga aaaatcttca
    12361 aaataaataa ctttttcggt tctactttgt acactttatc tacctggtag acctaattgt
    12421 tattgcttta caggtctaaa attcgtcgtt ataatctagt taaatcccgt aagggcgcac
    12481 ttatacgtcg gataaatcga catgtgcaaa aacgtaatcg accttcgtcg atttttttat
    12541 ttcaaaatta aagaaacggc ttgagatatt ccgagcagtt ataaaaatta atttgcgttg
    12601 aatattgcta ctacattctt gaaaaagtga tgtagattta tagcccataa cttttttgaa
    12661 ttacatcgac gatacggcgt cgaaagaaaa ataaatagac cgtatgaaag aaaaagctac
    12721 ctcactttat cttaagtagt tcagttttgg agtacaaaaa gtgaaaatgt aaacctaaat
    12781 gagtatcaaa ttgcaactga atttgatact cgttttttat tgttaaatca acgtttgttg
    12841 ttaatttaca ccacaaaatg taagttaaaa tgtatataaa aatgcgaacg tgaaataatt
    12901 attgtaggaa tgcaaattgg tgtgttaaaa tggttacaat ttactaagca aaaaggggtg
    12961 cattttccta tgcaatttct tgagccaaaa aataagaacg ctaagtctgt ggattgggaa
    13021 atatcagagc aagtaagggt gatagttaag caatacgctg aatatgcaga gcgtactgaa
    13081 agcgaagcag tggatgaatt cttattgaac attttagacg ataagaagtt tattgaatgg
    13141 attgccaaca agcgaagtaa taagcggatt gttgaaaaaa tgggtatcaa agatagagtg
    13201 ggttgataga caatgaccaa gcttaaaaga ttagccacga aggaagatga aattgtagat
    13261 gttaaaattc cgatttcaaa cgaagaatta aaagataggg ctaaacaata tgatttatta
    13321 actccaaaac gatttgcaac aaggtataac aaaatgttgt tcttgccaac gtcttttaaa
    13381 tggaacggtt ctgaatatcc cattcaatat aattactgca tcaatccgtt ttgttgtaat
    13441 tttgggaaag aacagcacaa attcaaagat gtaaaaggga aaccaagtcg atataaaatg
    13501 actggtagtt ccaaagataa aggtcataaa ggtatgtact gcaatgacaa tcctattggc
    13561 agaggtgtat cgcaaaactg tacagtaacc cctttatcta attggtctgt tgttgaagaa
    13621 attaaacgcc ttatagaaat caatagcatc caagatgttg agccagatta tcaatttcat
    13681 aaagaaggct gctcggaaga agaatcaacc ccattcaatg agccgaagca attttacaaa
    13741 agggggaaaa gtaggggcaa atctcaacgc tatcaatgta aggcgtgtaa gaagttcact
    13801 aatgttctac caaaaagaga agaaaccact acttatcacc aacaaaagaa caccattctt
    13861 ccaatgttcg ctaagatggt tgttggaagg gtttcagtca gtcgtacttg tgatatttta
    13921 ggaattggag ttggaaccta ctatcataag ctggagtggc tgtataggcg ttgtttggag
    13981 tttttagaac gatatgagac acaacccctt caaacaaaga aatttaacga gatgtggctt
    14041 aatacggaca agatgcacta ctacctaaat aacgtccgta agaaaggaca aggttcaaag
    14101 aaatatacgg ggtttgaaga ccttaatatg caaacgtata tagttgtatc tgctgaggtc
    14161 ttatcaagat atgtgttccg ttctgatgtt gcctatgatt ggaatatttc aatggatgaa
    14221 ttaaatgaag atacaagaaa attcaaagaa gaccatctca atacttttag tcgtaaaaat
    14281 gataggttag attggtctta ttatccacaa gaaccatccg ctaacgatag cgaaaatagg
    14341 aatgcttatc ttcacgaatt agggaaaatt actaatagga gtagatttgt cgatggttta
    14401 aatgttgatg ctccttatac tacaactgct cactattggt taattaaaca aatggttaat
    14461 gccgacgaat ggcgaatgat tagtgatgat gacttctcta ttagaaacgc cttttataga
    14521 gtattcacga aagaattaag gttgagcgat gcacatcatt ttatttgcca agttaacaag
    14581 acgaaaagca gaaaacaatg cttaaaagaa ttcggacaag caaaagcaga actgctcgat
    14641 tggggagata tcagaggatt caaaacaaag tttctacgga ctttggcatc tcattatcta
    14701 actgaattac taacaagtca tcaattccac gaagaggcta ttagtaaaga tggagaaaga
    14761 tatcgcaaat atgccgataa ccctatcaaa catccattag ccactaagga taaaggattt
    14821 tattcagttg attgtagaac ggatttatct gctctggaac caaacgaaat cgcaaagatg
    14881 ctattaaatg ttaatgacca ttcgaccaat agctttattc aacagataag acgttatata
    14941 tcatctcttg aaagaccatt aacaacagct cgtggtgata agaagagcta tatttacgct
    15001 aacttcaatc cgaagtatgc tcaatttgcg attacaattc taagaactta ctacaacttt
    15061 tgtcgccctt ttaaatcagc ggataaaaag gttttgacac ctgctcaaag attagggatt
    15121 acagataaac aatttgattg gaaagatata atttatttca aatgacaaaa agagcttgga
    15181 gtaatcccaa gctcttgtgc tttatcttta ctgttcttct tcaattaacg cacccgttaa
    15241 ctcaataagt tttttctttc atatacatga aaatagtagt tatacggatt tttatcattc
    15301 tttatccctt tttgggcaaa tacctcattc cattcctcat aattcacttc tggaaaaaaa
    15361 gtatctcctt cgaattcatg atgtattttt gtgatgtaca ttttctcaac ataagggaaa
    15421 aacaaattat aaatctgttc tcctccgaaa ataaaaattt cttcttcgtt tttacataac
    15481 tcaaaaacat cttctattga atgaacaatt tcacaaccat taaaggtaaa ccccttatct
    15541 ctcgtcagaa taatatttct tctgtcaggt aaggctcttc cgattgattc aaggttcttc
    15601 ctacctaata ttatcggatg tccctttgta gtatttttaa catattccca gtccttggga
    15661 atcctccaag gaatgtcatt ctctttgcca atcactctat tcttatccat cgcagcaatc
    15721 aaagaaactt tcatttataa cacagccttt ttaactaatt taccatctaa tttcttattt
    15781 ctatcaaaaa accttttctc attatcctgc ccgttagttg aataagcaat tttttctata
    15841 agttatatta tcataatacc acaaaatcac aaattttcat tcaattatca ttttcaattg
    15901 cattttataa atcattttgt atgtaatttg gtatgtaagt taaaatgaaa aaagtagtcc
    15961 attttgaagt acattttgtc attttgtact ccaaaactga actacttaac tttatctggg
    16021 gtagctttta ttttttatgc ccttattttg aattttaaga gggcatttta aagatttagg
    16081 ggtgattcat atagttttat atctaaaact tatatatgct tttaaaacgc aaatatgagc
    16141 caaataaata tatgctattt tcaaaaacaa aaatttgagc aaaaacaata actattttta
    16201 gacactgccc atttacatgc aaattaaaaa ttagcataaa attctttaaa acttccccac
    16261 gtttttctaa attcctgtag ggcgttttta tcaaaaatca agacaagaag aaactcgttc
    16321 acactcgttt caaaaaaaca agaaatctaa tctatacacc taccgttttc caaccccctc
    16381 aaagcataca aattaaaaac aaaattattc ataatcttac tttcttttaa caaaaacata
    16441 aaaaccataa atagacaaat taactatcaa aggcaataaa cagtataaaa aaaccacgaa
    16501 taaatcttca tcaacatcta aaataaaaaa gaataaaaca attaacaaaa tactaattaa
    16561 caaacctaaa agtggcaaac tttttatata tttttctaaa ttttcattca taaaatagac
    16621 tcctttcaaa aatatgttta taaatatatt aaaataaata ttgattttat aaagcgctta
    16681 cttatacaat taaaatatct tattatcttg gaggtatcaa atgaaaatta taaaattatt
    16741 ttcaataatt tccttgttcc tactggtatt tagcgcgaat ttttctaatg cttacgcaaa
    16801 tgaagaacaa aaaagttctt tactagaaaa tcaaaaagaa aaattgaaaa gcaaaaacat
    16861 cgaagtatca caaatgacca agaaagaaat aagttttcta gaacaattgc aaaataaaaa
    16921 tgaagatatg caaaaattcg aaaagcaaat gaaaaaagaa ggatttaaaa aaataaagct
    16981 agaagacaaa aattctaaat taaaatatct agctacagaa gcaaatgata aaaatgcata
    17041 tggctacata gctaataacg cttataaaaa tgaaaaaaca aaagaaattg tagtttctga
    17101 aacaatatat gataactaca acaaaaaaat cacaaaattc attgccgaaa aaagaagtat
    17161 gactgaaaac aaagagggaa aaatacttat taacaaaaat tacgttgaat ataaggctga
    17221 aaaagttgat aaaaacagac cggtaacata tgcaggattc aaatggaacg gcaaagcatt
    17281 cgcttgtagt atggctggac tttatgcatg tgctcactac tgtggagtat gggcaatcgt
    17341 aaatccaata gccggcggtg tatgtgaagc agtttgcgga actgcatttg cagctggatg
    17401 ctctgtaggt tgattttatt ccaattgttt tattgacgtt gagcctcgga acccttaaca
    17461 atcccaaaac ttgtcgaatg gtcggcttaa tagctcacgc tatgccgaca ttcgtctgca
    17521 agtttagtta agggttcttc tcaacatcaa taaatttttt cggcataaat acgatgttcc
    17581 ttatttatcc tcataaaaaa caatagctga aatatataac caattactgt gtgtttgaat
    17641 ttctaataca tgaatatcat tctttaaaaa cctattaact tgtttatcta attgacgatg
    17701 agtaaaagta gcgaaagttt taatcttcat gatatctctc cttttataaa aatagcaatc
    17761 cttattacaa tattaaacac ttttattttg gattttaaga ggcattttga agacttagag
    17821 gcaaatcata taggttttgt acttaaaaat ctatacagtc tcttaaaacg caaatatgag
    17881 ccaaataaat atatgctaat ttcacaaaca aaaatttcag caaaatcagt gactaatttt
    17941 ttagatactg cccatttaca tgcaaattta aaaattagca taaaatactt taaaacttcc
    18001 ccatgttttt ctaaattcct gcagggcttt tcttatcaaa aacttagaaa ttttaattta
    18061 actctaaaat ctccgtaaga gcataaggga aatttgctat cattcaaaaa tgatagatct
    18121 ggcaaggcca gacattccaa gggttttaag ttattttaaa gtgatatcat acaaagctgt
    18181 agtgtcacac ttttgtgaca ctacatacag catttgtcac aaaaataaga cagcactttt
    18241 ttacagaaaa acaataaaaa aagacatcag ttatcactaa tgtcttaaat aataattttg
    18301 cttttcgaaa ttccaaattg cggtaattga atgtgctttt tttcttcgtc tgtcgtttta
    18361 tcttcatcac ttgtattaat caaattacca tcttcggcat cgtctaagtt taaaatttta
    18421 tgcttttgtt taagcaatcc accataactt aacatacgtt ttcgatacaa acctttttct
    18481 aaatcactta caatttcttg atttttttcg tcgtcatcag ttaaaaagtc agatgattta
    18541 acggaatatt ttgatgtctc ttcgagtgtt ataaaatcat ttgaattatt gattaaagat
    18601 attatattgt ttcatgtttt tacggcgcat ataaagggca tgtgtttctt caagttcagt
    18661 tagaattgtt tgcattaaat aagcttgcat tgacttgatt gtttcctttt ggcctttaac
    18721 tcccctatca tgtatagctt ttttaagtct ttttaaagaa gttaatattt catcctcaat
    18781 gtcctctaac atgtaatgca tatcttcatg ccttgaatta aatgattttt ttgctttaag
    18841 aataacagcc tttatgattt ctaaatctct ataatcatat tttaataaat aattagttag
    18901 ttgttctggg aattcttgca atagcatttc tttatcatca aaattatgtg taaattgatt
    18961 tgaatgattt gaatgattac taatttcatt tttgtacttt atatcattca agtcattcat
    19021 atcattattc tcagtatcat taaagtcaat gtcattaaag tcagtatcat tagtgttcga
    19081 ttttcgaact tctggacgtt cgattttcga acttctggac gttcgatttt cgaacttctg
    19141 gacgttcgat tttcgaactt ccttctcgcc gtaaggttca acatcgtttt cttctttttc
    19201 tattttgtaa atatcacgtt ctgtgacaat aggtttcatt aaatatagaa tatttggttt
    19261 atttaaacca cgtcgttttt gaatgagtag accatcgttt tctaaccctt tttttatttt
    19321 tgttaacttt tcttttttac aatttaagat ttccattagc ttttcatttg aataaacaaa
    19381 gtaaatgtta ccatcttcat caacccagct atttttaata gataaattta agcgatcacg
    19441 taagatagca taggctattt tcatatcatt agttagattt ttataatttt cactggtaaa
    19501 gaatacttta gggatttgat aaaatctttc tttgtaattt tcttgcactg taaaatattg
    19561 attttgcatg acaaaaaacc tctttccata ttttagtttg gtaagaggta ataaaacgtt
    19621 tttatttagc tttacattta tttaatgatt taggtgcttg cactaagata ttattcatta
    19681 tataatacaa gtatcgaaaa ttatataaat aaacagtttc taaacgtttt attaccaaac
    19741 cccgactatt accagtagtt ggggtttttg ttatattaag tttattatag cactttaaat
    19801 aaacttataa aagggaaaat atagctttat caagggttta taaacccttg ataaatatca
    19861 taaacctttc ataaaccctt gataaaaagg ttgatggatg tttattttta tttattaatc
    19921 actttattat taagcattat aagcttataa tattttatca agggtttata aacattttat
    19981 aaagggttga tgatatgaaa agtgtgaaaa agttgagtga agaattaggg gttagtaagc
    20041 aaacgatttt taataatatt aagcgattga atatagagac aataaaacag gaaaacactt
    20101 cgtttattaa agaagatacc gatatagaaa aaatcattca aagagtaaat gaaaataaaa
    20161 agaaatatgg ttttgaaagt actactgaag acaaacaaaa aaaagggtcg gataatatta
    20221 attttgaatc gaaaagcgat gctcaaatag tagaaatcct taaaaatcag attgatactt
    20281 taaataatca aattgaaaaa caagaaagtc gtcatgaaac aacaattgaa ttttacagaa
    20341 aagagttgca agaaagatca aaattgcttg aaaatcagca agttctggca ttagagagta
    20401 ataaaaagat tcaaaaatta gaaaatcaat tagaaaaaga aaaacacctt aattatccct
    20461 ttgatacatc tactaacact agacaaaacg ttgatgcaca agaaaaaaca tatactacta
    20521 atcctgtaaa tattaacaga gatcaggaag aaactaaaga aacagagatt caatataagg
    20581 atatatctgg aagtcaaagc gacgaaagta cacaaggtga agaagcaaaa aaagaagacg
    20641 ttccagctaa tctaaatgac aatgatagtg atatagaaga aaagagtgaa gaaacggaac
    20701 ctaaaaaggg gttttggagt cgtttgtttg gtagctaaaa taattgatta ggcactaaaa
    20761 gttataaaat tttagtgtct tttatatagt gagaacttct ggtaatcatc gattatgtaa
    20821 actaaagtat ttcaaataat taactgtatt aatactctca tcatgattgc gttataaacg
    20881 ttcgttattg agacaaaatt taatagtact actacacaaa aagagagtgc gaattcgcac
    20941 tctctttttg tgataaatga atggttaaga aaataattca tccacagttg tatcaaacaa
    21001 tcttgccaac ttaaatgcta atgtcaatgt aggatcatat ttattgtttt ctattgcatt
    21061 aatagtttgc ctagacactt ttaattcttt acttaaagtt tcttgagaaa ttcctttttg
    21121 ttttctatat tctctaattc tatttttcat taatttaacc tttagatgta tattttttat
    21181 ttgtagtata gtaattaaac agcataagaa atagtgctac aattataaag aaaatttctg
    21241 gatattgaga aaaccaagat ccttcaatac ttggtgacaa acctgtaaat ttaagcacta
    21301 gtgtaaataa catacaatat acaatccaaa taaaactttt agccagtatt tcaataaaca
    21361 ttttacgttg tctttcatcg tatcgatctt gttgtccttt tttatctaat gtttctgaag
    21421 gtaaatattt gttagttata gccgtccata aacaagaaaa aattaaaata ataataaaag
    21481 gaattaaatt cattataaca cctcataaat gtaaaaagta tttgacattt atgagtgtaa
    21541 atatttttga tacaaatgtc aaatactttt tacattataa tatattttaa aacaccttat
    21601 tagtaaaaca attactatat agaaagctgc gaactcgtac tcttttttct tgtataatta
    21661 ttaaaatctc aattcaataa tatgttatgg aatttgagac actgtgagag acgctcattt
    21721 gcattgacaa tcaatttatc aagataatcc cttatcatgt ttaattctat aaactgtttg
    21781 tcttgtgata ttaacttctt tcgcaatctt actaatcgct ttgccttctt ctaacatttc
    21841 caccacgcga tgataaataa cacgtttctg tgggtcttta gcatttggtg aataaagtaa
    21901 agggcgccct ttatatacgc ctttttcctt cgcaacttga atcccttgcg cttgtcgacg
    21961 tttactttca tttctctctt gttctgaaac cattgctaat atttgaatga ttaaatcttt
    22021 cataaactta tccagtaatg gattgccaat tacttcattc atcataggta agctggtaat
    22081 cattaactga acgtcttttt cttttaaata attcacagtt tcaataattt catcatagtt
    22141 acgtcctaaa cgatcaatag attccacaac gaatcgatct cccattctga caaaattgag
    22201 tgcttcttga aatacaggtc tattttccac tgactttccc gactgtttct ctgtaaagat
    22261 tttctccaca ccaaacgtct ttaaattatc caattgtctt tctaaatttt gatctatcga
    22321 tgatactctc gcataaccta taatcattca tcttcactcc ataataaata tacaccctaa
    22381 tcatacgttt taattgttat aatttcaaca attctttttg tatggttagg gtgtactcaa
    22441 agtgtacata tctataatta aaacttacta aaaataaata tagatttttt ctttgtaaca
    22501 gaaccgttca tttgaaggtc atctctatca taaatattta aattaactaa aaattttaat
    22561 catctgttta atacttatga aatgtattta cggtaggtat taaaattgat gaaatttata
    22621 taagtgcttt caatgaaaat gaccgtttat ttatcctcct gatttaagga gttagaaatt
    22681 tcgaaaacga ttctttccat ttgttgcatt tgttccatgt ccagatattt aatacattat
    22741 agaaaaccaa agaccatcac taattaaacg cagttttaaa atttcatcag gattgccttc
    22801 gtctttaaaa tgggcctctt ttaatataag ttctactctt tcatacctaa ctctttcaat
    22861 gccatcgttt catacgccga ttctcctgat tccatagcaa actcagcgat aaacattggg
    22921 aatactgcat tgagttctat tatatgctct ttcattcgtg gccatatttc acctccagct
    22981 ttaccgtatg ctgttataag ttgctctaat ccttcgtcgt cgaatacacg atggtgtcct
    23041 ataaagtcca ttgatgggtc ggagtgggtt gcttcagtcc agtctatgag acctgtgacg
    23101 tttgcttggt tatctaccat tatatgtcct ggatgtaagt ccccatgtat catggtcgca
    23161 tgtcgaggcc atagttcgtc gttttctaac cattgtttcc atctgttcca taattcatct
    23221 gatacgccat aagtttcttt aactttattc attcttcttt gaaagtcatt ttttatttct
    23281 tgtatggttt tgatatttat atgctgaacg ttaatgtttt cttctggtat gttgtgtaaa
    23341 tctacgagtg tttcagctaa tgtgttaata aagttttctg gtaatggttt gtgttcaatt
    23401 tcccatacat aattttgtat ttctggatct attgtggctg cgggtttacc tgtaagtttt
    23461 gggtaagcaa taaggtcttt tgcatgtact ttccacttcg gtatttcaaa tgaaacattc
    23521 ttctgtaaga agtctaccgt ttgtttttcg ggttttgttc gtttataaac gtcaggtctt
    23581 cttggtagtc tcaaaaccca ttctactcca tgtttatctt ttccaaatgc aacttgaaaa
    23641 tcaagtcccg attcattcaa tgagattgtt tgaggttgga tgtgtaattg atatttttct
    23701 gcacatttaa taatttcatt atgtcgagtc attttattgg atccttattt ctattatatt
    23761 tttcttgtga acgtattttt tatattgata taaatgaacc taatattcaa tataaattag
    23821 tgtatagttt ttaagttata tcatgaagag attgtcctgt taattcccat tttttatctg
    23881 atacatgttt aacaaacctt gtatcatgtg atgtaaacaa aatgattcca ggatatttat
    23941 tcataaacat ttctaatgct tctaatgttt taatatctaa aaaattagtt ggttcatcca
    24001 aaattaacat attcgctttc gttgaaaata atactgctaa cgataatttc gttctttccc
    24061 caccactcaa aacattacaa gaacgatcaa gtgcttcatt taaacccaag ttatttaaaa
    24121 tagctctact gaatgattct gatgaatccg tttcatccat taaatattgc aataatgaaa
    24181 cgtcacgcat gtcttcataa gcaagttgac gatagtatgc catttgcact ttaggagaac
    24241 aatcaattcc ctctatttgg tggtaaatag cttcaagtaa agttgtctta cctacaccat
    24301 ttgcacctac gagcgctata tttttgccat atggtatttg gaatcgtact tgtgttagca
    24361 gtttttgact tcctttaacc aatgttagat tttgtgcaat gattggataa ttattatgga
    24421 tatcataaat tttattttgt gggaaattga attcatgata actttgtggt ttttcaactt
    24481 cttccaaatg ttccattctt ttttcaatat gcttagcttg tttttgagca gccttctcaa
    24541 ccgtgccttt ttgttttgat gcacttaaac gatctggtgc tatacttttg tttttttgtt
    24601 ttgatgatgc ttgtgccatt tgttgcgctt gatttcgttt agctttactg gcttgggaca
    24661 atctttgttt ttcacttata tactgttcat attgacgttg ttgttctaac tgttcttgtt
    24721 catattgatt ttgatactgt gtgtaattac ctttaaacac tcttattgtg ccatcttctt
    24781 gtatatccca aattgtgtca gcaatttggt ctataagtgc tctatcatga cttactataa
    24841 ttaaagtacc atagtaatat tttaaaatat ttttcagata atctttacca attttatcca
    24901 agtgatttgt aggttcatct aaaagtaata tcggactata atttgatatg acattagcta
    24961 atttatattt tgctttttca ccaccactca tactgtcggt tgtatgcata ggtatatgga
    25021 gttcactcat taaactaccg tctaacgtgt taaaatcatt ttccacatcc atgttaagct
    25081 gttcaaaata ttgaatttcg ccaaccgttt caactgttcc agattctggt tttgtttttt
    25141 gagcaatcat atttagtaat gtggttttgc cagtaccatt acccccaata agtgctattt
    25201 tttcaaattg gtaagcgtaa agatgaccga tgttaagtga tcgtaaatct gtcaatttat
    25261 gattgatttg gttaaattta attgtatatt gttccatatt tatacactcc ttgtatattt
    25321 aaaggacgtg tacgcaaaaa aatgagacag gctactcccg tctcattcac attacacttt
    25381 caaacactta aaaatttatt atgatgtttt agtatttgaa agcgtttatt attcctatcg
    25441 aaggataaaa aatgacataa gtcatcctat gagtgtgtat tgcggacaag cctttttgaa
    25501 ttaatttagt tttgtattca aaaaggttta tttgagtctc atagaagctg tcattttaat
    25561 cctccttcat cgataaaata gtaatgttaa tataacattt tgttggtttt tttacaatat
    25621 atctctaagt agaaagatta tataacaaaa gtataaaaat acaattttag attgattata
    25681 catctcctta atttagagtg tactcataaa atacggttct gttgcaaagt tgaatttata
    25741 atataatttt aacaaaaagg agtcttctgt atgaactatt tcagatataa acaatttaac
    25801 aaggatgtta tcactgtagc cgttggctac tatctaagat atgcattgag ctatcgtgat
    25861 atatctgaaa tattaagaga acgtggtgta aacgttcatc attcaacgat ctaccgttgg
    25921 gttcaagaat atgccccaat tttatatcaa atttggaaga aaaagcataa aaaagcttat
//
