LOCUS       NZ_CP010403            28895 bp    DNA     circular CON 21-MAR-2024
DEFINITION  Staphylococcus aureus strain GR2 plasmid pGR2A, complete sequence.
ACCESSION   NZ_CP010403
VERSION     NZ_CP010403.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN03267304
            Assembly: GCF_001296985.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 28895)
  AUTHORS   Sabat,A.J., Pournaras,S., Akkerboom,V., Tsakris,A., Grundmann,H. and
            Friedrich,A.W.
  TITLE     Whole-genome analysis of an oxacillin-susceptible CC80 mecA-positive
            Staphylococcus aureus clinical isolate: insights into the mechanisms
            of cryptic methicillin resistance
  JOURNAL   J Antimicrob Chemother 70 (11), 2956-2964 (2015)
   PUBMED   26198147
REFERENCE   2  (bases 1 to 28895)
  AUTHORS   Sabat,A.J., Pournaras,S., Akkerboom,V., Tsakris,A. and
            Friedrich,A.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2014) Medical Microbiology, University of
            Groningen, University Medical Center Groningen, Hanzeplein 1,
            Groningen 9700 RB, The Netherlands
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SeqManNGen v. 12.1.0
            Genome Coverage                   :: 50x; 133x
            Sequencing Technology             :: 454; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001296985.1-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 04:56:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,802
            CDSs (total)                      :: 2,724
            Genes (coding)                    :: 2,649
            CDSs (with protein)               :: 2,649
            Genes (RNA)                       :: 78
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 75
            CDSs (without protein)            :: 75
            Pseudo Genes (ambiguous residues) :: 0 of 75
            Pseudo Genes (frameshifted)       :: 30 of 75
            Pseudo Genes (incomplete)         :: 37 of 75
            Pseudo Genes (internal stop)      :: 17 of 75
            Pseudo Genes (multiple problems)  :: 9 of 75
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP010403.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..28895
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="GR2"
                     /isolation_source="Swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pGR2A"
                     /geo_loc_name="Greece"
                     /lat_lon="39.63 N 22.41 E"
                     /collection_date="2006"
                     /collected_by="Prof. Dr. Spyros Pournaras"
     gene            complement(255..863)
                     /locus_tag="RT44_RS14115"
                     /old_locus_tag="RT44_14145"
     CDS             complement(255..863)
                     /locus_tag="RT44_RS14115"
                     /old_locus_tag="RT44_14145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000776990.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000776990.1"
                     /translation="MKLSAKKQKQFHHFCNYFKSLEIKTFLQNAIGALFLSPFTLITYA
                     FILAYKVTFMNKSLIEALSSAVSLILIFWVVALYLMMFYVVYFKGKNSLLKFVKITTLI
                     IIISYHIYIFIRKGIENLTHFDNYIIIITSVLISYWLIQTLRNIITSIYNWIFNDESHQ
                     RDELIKFKLSFIKSLLIGFFSFIATILGIALTIKNLFFT"
                     /name="hypothetical protein"
     gene            1336..1977
                     /locus_tag="RT44_RS14120"
                     /old_locus_tag="RT44_14150"
     CDS             1336..1977
                     /locus_tag="RT44_RS14120"
                     /old_locus_tag="RT44_14150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000855537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fusidic acid resistance EF-G-binding protein
                     FusB"
                     /protein_id="WP_000855537.1"
                     /translation="MKTMIYPHQYNYIRSVILRLKNVYKTVNDKETVKVIQSETYNDIN
                     EIFGHIDDDIEESLKVLMNIRLSNKEIEAILNKFLEYVVPFELPSPQKLQKVFKKVKKI
                     KIPQFEEYDLKVSSFVGWNELASNRKYIIYYDEKKQLKGLYGEISNQVVKGFCTICNKE
                     SNVSLFMKKSKTNSDGQYVKKGDYICRDSIHCNKQLTDINQFYNFIDKLD"
                     /name="fusidic acid resistance EF-G-binding protein FusB"
     gene            2243..2506
                     /locus_tag="RT44_RS14125"
                     /old_locus_tag="RT44_14155"
     CDS             2243..2506
                     /locus_tag="RT44_RS14125"
                     /old_locus_tag="RT44_14155"
                     /inference="COORDINATES: protein motif:HMM:NF018184.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GyrI-like domain-containing protein"
                     /protein_id="WP_223223663.1"
                     /translation="MNYKIEILDDCNVIYVRNKGKYGSNKNYEMMKNFKEWIKENCYWR
                     YVETNGILGVALDDPQIVEEESCRYDLVLKIDEDVKIGSVAK"
                     /name="GyrI-like domain-containing protein"
     gene            complement(2547..3221)
                     /locus_tag="RT44_RS14130"
                     /old_locus_tag="RT44_14160"
     CDS             complement(2547..3221)
                     /locus_tag="RT44_RS14130"
                     /old_locus_tag="RT44_14160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WP_001105960.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            3489..4334
                     /gene="blaZ"
                     /locus_tag="RT44_RS14135"
                     /old_locus_tag="RT44_14165"
     ARG             3490..4331
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            4414..5088
                     /locus_tag="RT44_RS14140"
                     /old_locus_tag="RT44_14170"
     CDS             4414..5088
                     /locus_tag="RT44_RS14140"
                     /old_locus_tag="RT44_14170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WP_001105960.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            <5149..6807
                     /gene="blaR1"
                     /locus_tag="RT44_RS14145"
                     /old_locus_tag="RT44_14175"
                     /pseudo=""
     ARG             5150..6804
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="94.36"
     gene            6797..7177
                     /gene="blaI"
                     /locus_tag="RT44_RS14150"
                     /old_locus_tag="RT44_14180"
     ARG             6798..7174
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            7441..8019
                     /locus_tag="RT44_RS14155"
                     /old_locus_tag="RT44_14185"
     CDS             7441..8019
                     /locus_tag="RT44_RS14155"
                     /old_locus_tag="RT44_14185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690625.1"
                     /translation="MKIGYARVSTGLQNLNLQEDQLNQYGCEKIFSDHISGSKSKRPGL
                     DKAIEFARAGDTIVVWRLDRLGRNMEDLITLVNELNNRGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLKLLKTLYDNGTPI
                     KTIAEQWKVSRTTIYRYLNRLNNQENKDK"
                     /name="recombinase family protein"
     gene            8145..8753
                     /locus_tag="RT44_RS14160"
                     /old_locus_tag="RT44_14190"
     CDS             8145..8753
                     /locus_tag="RT44_RS14160"
                     /old_locus_tag="RT44_14190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002436987.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000635274.1"
                     /translation="MIVGYARVSSLDQNLERQLENLKTFGVEKIFTEKQSGKSVENRPI
                     LQEALNFVRMGDRFVVESIDRLGRNYDEVINTVNYLKDKEIQLMITSLPMMNEVIGNPL
                     LDKFMKSLIIQILAMVSEQERNESKRRQEQGIKIAKEKGVYKGRPLLYSPNAKNPQKRI
                     IYHRVVEMLEEGQAISKIAKEVNITRQTVYRIKHDNDLI"
                     /name="recombinase family protein"
     gene            9025..9393
                     /gene="cadC"
                     /locus_tag="RT44_RS14165"
                     /old_locus_tag="RT44_14195"
     ARG             9026..9390
                     /name="cadC"
                     /gene="cadC"
                     /gene_name="Cd(II)/Pb(II)/Zn(II)-sensing metalloregulatory
                     transcriptional repressor CadC"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM/LEAD/ZINC"
                     /identity="99.18"
                     /coverage="100.0"
     gene            9386..11569
                     /gene="cadA"
                     /locus_tag="RT44_RS14170"
                     /old_locus_tag="RT44_14200"
     CDS             9386..11569
                     /gene="cadA"
                     /locus_tag="RT44_RS14170"
                     /old_locus_tag="RT44_14200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000003267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cadmium-translocating P-type ATPase CadA"
                     /protein_id="WP_000003268.1"
                     /translation="MSEQKVKLMEEEMNVYRVQGFTCSNCAGKFEKNVKKIPGVQDAKV
                     NFGASKIDVYGNASVEELEKAGAFENLKVSPEKLANQTIQRVKDDTKAHKEEKTPFYKK
                     HSTLLFATLLIAFGYLSHFVNGEDNLVTSMLFVGSIVIGGYSLFKVGFQNLIRFDFDMK
                     TLMTVAVIGATIIGEWAEASIVVILFAISEALERFSMDRARQSIRSLMDIAPKEALVRR
                     NGQEIIIHVDDIAVGDIMIVKPGEKIAMDGIIVNGLSAVNEAAITGESVPVSKAVDDEV
                     FAGTLNEEGLIEVKITKYVEDTTIAKIIHLVEEAQGERAPAQAFVDKFAKYYTPIIMVI
                     AALVAVVPPLFFGGSWDTWVYQGLAVLVVGCPCALVISTPISIVSAIGNAAKKGVLVKG
                     GVYLEKLGDIKTVAFDKTGTLTKGVPVVTDFEVLNDQVEEKELFSTITALEYRSQHPLA
                     SAIMKKAEQDNIPYSNVQVEEFTSITGRGIKGIVNGTTYYIGSPKLFKELNVSDFSLGF
                     ENNVKILQNQGKTAMIIGTEKTILGVIAVADEVRETSKNVIQKLHQLGIKQTIMLTGDN
                     QGTANAIGTHVGVSDIQSELMPQDKLDYIKKMQSEYDNVAMIGDGVNDAPALAASTVGI
                     AMGGAGTDTAIETADIALMGDDLSKLPFAVRLSRKTLNIIKANITFAIGIKIIALLLVI
                     PGWLTLWIAILSDMGATILVALNSLRLMRVKDK"
                     /name="cadA"
     gene            complement(11639..12313)
                     /locus_tag="RT44_RS14175"
                     /old_locus_tag="RT44_14205"
     CDS             complement(11639..12313)
                     /locus_tag="RT44_RS14175"
                     /old_locus_tag="RT44_14205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105994.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKVAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            12477..12620
                     /locus_tag="RT44_RS15235"
                     /old_locus_tag="RT44_14210"
     CDS             12477..12620
                     /locus_tag="RT44_RS15235"
                     /old_locus_tag="RT44_14210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002500462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAS049 family protein"
                     /protein_id="WP_000011355.1"
                     /translation="MSFVDKAKDAAEKFKNSDNEQVNKVKDQINEYTGGEKHDNKDKKD
                     DK"
                     /name="SAS049 family protein"
     gene            complement(12736..>12930)
                     /locus_tag="RT44_RS14955"
                     /pseudo=""
     CDS             complement(12736..>12930)
                     /locus_tag="RT44_RS14955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612030.1"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /name="IS3 family transposase"
     gene            complement(13199..14194)
                     /locus_tag="RT44_RS14185"
                     /old_locus_tag="RT44_14215"
     CDS             complement(13199..14194)
                     /locus_tag="RT44_RS14185"
                     /old_locus_tag="RT44_14215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829391.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative sulfate exporter family transporter"
                     /protein_id="WP_000836459.1"
                     /translation="MKSITQPSFMKGIMFTFIIAMISYILAEFPILHTIGALAIAIIFA
                     MIYRQVIGYPEHIRPGITFASKRLLKFAIILYGLKLNMGDILGKGWKLLLIDIIVIIFS
                     ISLTLILNQIIKGNKDISILLGIGTGVCGAAAIAATAPILKSKEKDIAISVGIIALIGT
                     IFALIYTAIKAIFNIPTITYGAWTGISLHEIAHVVLAADIGGPEAMTFALLGKLGRVFL
                     LIPLSIVLILYMRYKSHSSQVQQKVDIPYFLIGFILMACVNTFIPIPSLLMNIINVITT
                     VCMLMAMVALGLNIVLKEVISKALKPFIVICITSICLSGVTLLVTSIMFK"
                     /name="putative sulfate exporter family transporter"
     gene            14309..15130
                     /locus_tag="RT44_RS14190"
                     /old_locus_tag="RT44_14220"
     CDS             14309..15130
                     /locus_tag="RT44_RS14190"
                     /old_locus_tag="RT44_14220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002458575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_000371597.1"
                     /translation="MDPYKVLIEVMKTESFTRAAEHLYTSQPSVSRDIKRLELKYHVKI
                     FEFKSPYLKLTRDGEKLLQYALQRESIEQELWQNLTSESEIISGTLTIGSSYTYGEYLL
                     SKQLTSLMQQYPKLHIHLRVNNSDSVINDIKHNRVDIGIVEKEIQDNAIECKKIMEDEM
                     VYIYKKSLQPRMDICFVREKGSGTRFYQEVGLSELKLNPYLVEINNIKIIKQMVEAGNG
                     FAIISKSAIHPEDYEKLMITTLNVKRRYYLAQHVDKYIDKNIRTVIEMIMK"
                     /name="LysR substrate-binding domain-containing protein"
     gene            complement(15354..>15677)
                     /locus_tag="RT44_RS14195"
                     /old_locus_tag="RT44_14225"
                     /pseudo=""
     CDS             complement(15354..>15677)
                     /locus_tag="RT44_RS14195"
                     /old_locus_tag="RT44_14225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017175606.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="PfkB family carbohydrate kinase"
                     /name="PfkB family carbohydrate kinase"
     gene            complement(15930..16697)
                     /locus_tag="RT44_RS14200"
                     /old_locus_tag="RT44_14230"
     CDS             complement(15930..16697)
                     /locus_tag="RT44_RS14200"
                     /old_locus_tag="RT44_14230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002489261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_001259173.1"
                     /translation="MRTIKMVADELGVTKQTIVNNAKSLNITFEKENGINYIDDNDYLK
                     IIEKITKKESTIQNKESVKKELFGENTAKAEKNIYNNSNSSETLKTKVNELEKQIEIFE
                     TRAKNDEKYIENLTKQLDQQNSNVNTLNKLLENQQILALESNKKIQKLESQLEEERQLN
                     YSFDTATNNRQNINPQEATFTEESQNINQQQTKRQPTEVNYKDIAEEKKNDSTDEGELT
                     KEDKFVEETKSDSDDNREVEPPKKGFWSRFFGN"
                     /name="DUF536 domain-containing protein"
     gene            17137..18072
                     /locus_tag="RT44_RS14205"
                     /old_locus_tag="RT44_14235"
     CDS             17137..18072
                     /locus_tag="RT44_RS14205"
                     /old_locus_tag="RT44_14235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_001132436.1"
                     /translation="MPNFEKYNLSQVKTERFYQLPKYLFEDAYFKKMSAEAKIMYALLK
                     DRFELSIQNEWVDKNNNIYFIFSNKHLCEYLGYAEQKIIKLKKELISFNLLTQERVGLN
                     KPNRLYLLKPNYDIKASHSKELPNSQFQNNEFGSSRTVNLSGQELPNSQSNDTENNDTD
                     YIKTESNDTNDLNDNKLTFPSNHTNHSNHDNSNFNNEALKFQLLEELPQSIKNYLSNFE
                     VAEIKIIKTVLLKAKTSFNNAIDSYYLLEDMEIEILHVLKRFKAMLIQKNETVESMQGY
                     LMKSLKSEFAEMHTLNKRRDHLPITSLFNQ"
                     /name="replication initiator protein A"
     gene            19965..20423
                     /locus_tag="RT44_RS14210"
                     /old_locus_tag="RT44_14240"
     CDS             19965..20423
                     /locus_tag="RT44_RS14210"
                     /old_locus_tag="RT44_14240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000758108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1307 domain-containing protein"
                     /protein_id="WP_000758108.1"
                     /translation="MKKVTGLVVSIVFLITLSACGAEKTKTFVGEESNVKMEITYTYKG
                     DEIIKQKSVNTLKYSDFSLNDDTSKKIMKEAIEKESKKMQDVKGVKETVKENDEGIVET
                     ITIDLKNADIDTLKSKDIVSMSGNTGNGFSMKKTEKEMKKEGFKEKED"
                     /name="DUF1307 domain-containing protein"
     gene            complement(20862..21434)
                     /gene="merB"
                     /locus_tag="RT44_RS14215"
                     /old_locus_tag="RT44_14245"
     CDS             complement(20862..21434)
                     /gene="merB"
                     /locus_tag="RT44_RS14215"
                     /old_locus_tag="RT44_14245"
                     /EC_number="4.99.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001011857.1"
                     /GO_function="GO:0018836 - alkylmercury lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0046413 - organomercury catabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="organomercurial lyase"
                     /protein_id="WP_001011857.1"
                     /translation="MNFTKDLNQKENELRNNIINKICENPNKKLDVIPEYKSLIDKKVI
                     TTENDKIKCIYPISSEKTNKLVYTNKSKEPLFAMCAIDAIGIYYTTSLNILILSEDELT
                     KEKIKLEIKDNKIINHNKSNIYISYKDVCQKEDCDKNCCPYIHFFTSKNNAENYLNSLP
                     NKESHKILNLKQAKEISKQLFENNNLS"
                     /name="merB"
     gene            21650..21742
                     /locus_tag="RT44_RS15160"
     CDS             21650..21742
                     /locus_tag="RT44_RS15160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001791613.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            <21952..22218
                     /locus_tag="RT44_RS14220"
                     /old_locus_tag="RT44_14250"
                     /pseudo=""
     CDS             <21952..22218
                     /locus_tag="RT44_RS14220"
                     /old_locus_tag="RT44_14250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002458658.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            complement(22620..22829)
                     /locus_tag="RT44_RS14225"
                     /old_locus_tag="RT44_14255"
     CDS             complement(22620..22829)
                     /locus_tag="RT44_RS14225"
                     /old_locus_tag="RT44_14255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000739694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000739694.1"
                     /translation="MKKNKLKKYNLLLNICLISLSVYSIIFIAIFHIPYGKTIFFAIYF
                     IIIICFFFIDKKIEKDNKKENKDD"
                     /name="hypothetical protein"
     gene            23107..23781
                     /locus_tag="RT44_RS14230"
                     /old_locus_tag="RT44_14260"
     CDS             23107..23781
                     /locus_tag="RT44_RS14230"
                     /old_locus_tag="RT44_14260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001106022.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRGRGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(<23822..24067)
                     /locus_tag="RT44_RS14235"
                     /old_locus_tag="RT44_14265"
                     /pseudo=""
     CDS             complement(<23822..24067)
                     /locus_tag="RT44_RS14235"
                     /old_locus_tag="RT44_14265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000277654.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            complement(24594..25835)
                     /gene="mobV"
                     /locus_tag="RT44_RS14240"
                     /old_locus_tag="RT44_14270"
     CDS             complement(24594..25835)
                     /gene="mobV"
                     /locus_tag="RT44_RS14240"
                     /old_locus_tag="RT44_14270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010889940.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobV family relaxase"
                     /protein_id="WP_000122374.1"
                     /translation="MSYSIVRVSKVKSGTNTTGIQKHVQRENNNYENEDIDHSKTYLNY
                     DLVNANKQNFNNLIDEKIEQNYTGKRKIRTDAIKHIDGLITSDNDFFDNQTPEDTKQFF
                     EYAKEFLEQEYGKDNLLYATVHMDEKTPHMHYGVVPITDDGRLSAKEVVGNKKALTAFQ
                     DRFNEHVKQRGYDLERGQSRQVTNAKHEQISQYKQKTEYHKQEYERESQKTDHIKQKND
                     KLMQEYQKSLNTLKKPINVPYEQETEKVGGLFSKEIQETGNVVISQKDFNEFQKQIKAA
                     QDISEDYEYIKSGRALDDKDKEIREKDDLLNKAVERIENADDNFNQLYENAKPLKENIE
                     IALKLLKILLKELERVLGRNTFAERVNKLTEDEPKLNGLAGNLDKKMNPELYSEQEQQQ
                     EQQKNQKRDRGMHL"
                     /name="mobV"
     gene            complement(26021..27400)
                     /gene="tet(K)"
                     /locus_tag="RT44_RS14245"
                     /old_locus_tag="RT44_14275"
     ARG             complement(26025..27400)
                     /name="tet(K)"
                     /gene="tet(K)"
                     /gene_name="tetracycline efflux MFS transporter Tet(K)"
                     /tool="amrfinderplus"
                     /drug_class="TETRACYCLINE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(27562..>27945)
                     /locus_tag="RT44_RS14250"
                     /old_locus_tag="RT44_14280"
                     /pseudo=""
     CDS             complement(27562..>27945)
                     /locus_tag="RT44_RS14250"
                     /old_locus_tag="RT44_14280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000277654.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            28003..28677
                     /locus_tag="RT44_RS14255"
                     /old_locus_tag="RT44_14285"
     CDS             28003..28677
                     /locus_tag="RT44_RS14255"
                     /old_locus_tag="RT44_14285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001106022.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRGRGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(<28732..28839)
                     /locus_tag="RT44_RS15170"
                     /pseudo=""
     CDS             complement(<28732..28839)
                     /locus_tag="RT44_RS15170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015063485.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /name="IS6 family transposase"
     ARG             1337..1974
                     /name="fusB"
                     /gene="fusB"
                     /gene_name="fusidic acid resistance EF-G-binding protein
                     FusB"
                     /tool="amrfinderplus"
                     /drug_class="FUSIDIC ACID"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             3490..4334
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="95.02"
                     /coverage="100.0"
     Typing          17138..18072
                     /name="rep_cluster_1215"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(27564..27846)
                     /name="rep_cluster_1118"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="85.263"
                     /coverage="99.0"
                     /evalue="1.26e-76"
     Typing          complement(24598..25835)
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aatcaaacta tagagcaagc tggtaatgaa tttaaaaaat aaattgggat cataacgcaa
       61 taaaaagagg aagttgcaga gaaaaagata aaaataataa agacattaaa taattgtaga
      121 taatacaaaa cgctaagaaa tgtcctgtgt tgcagtgagg attgagtttg tgtgactacg
      181 gtaagttata taataaagga tgtcatgcta tacaacatcc tttataaatt gcgttctata
      241 aaaattaatt cgacttaagt aaagaataaa tttttaatag ttaatgctat acctaaaata
      301 gtagcaataa aagaaaaaaa gcctatgagt aaacttttta tgaaagaaag cttaaattta
      361 attaattcat ctcgttggtg actttcatcg ttaaatatcc aattgtaaat agaagtaatt
      421 atatttctca aagtttgtat cagccagtaa gaaataagaa ctgaagtaat aataataata
      481 tagttatcaa aatgagtaag attttctata ccttttctaa taaatatgta tatatgataa
      541 gaaataataa ttattagagt agttatttta acaaatttta ataatgaatt tttaccttta
      601 aagtaaacta cataaaacat cattaaatac aatgcaacta cccaaaatat aagaattaaa
      661 gaaacagcgc ttgacaaagc ttcaattaat gatttattca taaatgtaac cttgtatgct
      721 aaaataaatg cataagttat taatgtaaaa ggacttaaaa ataaagcgcc gatagcattt
      781 tgcaaaaatg ttttaatttc taaactttta aagtagttac aaaaatgatg gaactgcttt
      841 tgcttttttg ctgagagttt cataaaaaaa cactcctgtt tagcaagttt aattctatat
      901 aaaaactata aaaaatatat cataatgaaa ctttttctta caatactttt tgtaaaaatg
      961 aaatgatttg tttaatgata atttaaaggg caaaaaaggg tacagttttg aaataaagga
     1021 caagagtatg aaattattaa caatataaga cgttgagaaa cgttctgtgt tgcgatgagt
     1081 gaaacgatta actctggatt tacccatgtt atttttttac taagagtaac attatgagta
     1141 attaattaat attgaagtga tataaatgaa tttaacagtt cgggaggtga tgatgttatg
     1201 ttaaaagata taacatattt aaagctattg gatcttgaat ataagatgct ttgtagctaa
     1261 atttaatcaa cattatcaca aagtatctta tttattaata agtaaaataa atatacttgt
     1321 gaaaggttga aaacaatgaa aacaatgatt tatcctcacc aatataatta tatcagatcg
     1381 gttattttaa gattgaaaaa tgtatataaa acggtaaatg ataaagaaac cgtcaaagtt
     1441 attcaatcgg aaacctataa tgatattaat gagatttttg gtcatataga tgacgatatt
     1501 gaagaatctt taaaagtatt aatgaacatc agattatcaa acaaagaaat tgaagcaata
     1561 cttaataaat ttttagaata tgtagtacct tttgaactac ctagtccgca aaaacttcag
     1621 aaagtattta agaaagttaa aaaaataaaa atacctcaat ttgaagaata tgatttgaag
     1681 gtaagttcat ttgtaggatg gaatgaactt gcatcaaatc ggaaatatat aatatattac
     1741 gatgaaaaaa aacaattaaa aggactttat ggagaaattt ctaatcaggt tgtaaagggg
     1801 ttctgcacaa tttgtaataa agaatctaat gtttcattat tcatgaaaaa gtcaaaaacc
     1861 aattcggatg gtcaatatgt aaaaaaaggt gactatatat gtcgagatag cattcattgt
     1921 aataaacaat taacagatat taatcagttt tataatttta ttgataaact agattaagga
     1981 ataaactatg tttgtgaaaa ttgtgattgt taaataatat tgtttaccgt taattatgga
     2041 tataaatagc tttaaattca gagggcaaaa aaagggcata attttgatga taagggcaaa
     2101 ttaaatagtt agcacacgga caagttaaat aattcgtttc aagcgtcact cattgagtgg
     2161 cgtttttttt attttaagaa attttttaat acatattgta ataaatttta actcgggtta
     2221 gcttattgtt ggaggtgcta aaatgaacta taaaatcgaa attttagatg attgtaatgt
     2281 gatctatgtt agaaataaag gtaagtatgg tagtaataag aattatgaaa tgatgaagaa
     2341 ttttaaagag tggattaaag aaaattgtta ttggagatat gttgaaacta acggaatatt
     2401 aggtgtagca ttagatgatc cgcaaattgt cgaagaagaa tcatgtagat atgatttagt
     2461 tttaaaaata gacgaagatg taaagatagg ttctgttgca aagtaaaaaa tatagctaat
     2521 cactaatata tcatgtcagt gttcgtttaa cttgctagca tgatgctaat ttcgtggcat
     2581 ggggaaaatc cgtagatctg aagagaccta cggttctttt tatatagagc gtaaatacat
     2641 tcaatacctt ttaaagtatt ctttgccgta ttgatacttt gatatcttgt ctttcttact
     2701 ttaatatgac ggtgatcttg ctcaatgagg ttattcagat atttcgatgt acaatgacag
     2761 tcaggtttaa gtttaaaagc tttaattatt ttagccattg ctgccttcgt tgaaggtgcc
     2821 tgatctgtaa ctaccttttg aggcttacca aattgtttaa tgagacgttt gataaacgca
     2881 tatgctgaat gattatctcg ttgcttacgc aaccaaatat ctaatgtatg tccctctgta
     2941 tcaatggcac gatataaata gctccatttt ccttttattt tgatatacgt ctcatcaata
     3001 cgccatttgt aataagcttt tttatgcttt ttcttccaaa tttgatataa aattggggca
     3061 tattcttgaa cccaacggta gatcgttgaa tgatgaacgt ttacaccacg ttctcttaat
     3121 atttcagata tatcacgata gctcaatgca tatcttagat agtagccaac ggctacagtg
     3181 ataacatcct tgttaaattg tttatatctg aaatagttca tacagaagac tcctttttgt
     3241 taaaattata ttataaattc aactttgcaa cagaaccatt taaactataa ttaaaatagc
     3301 gttttaatat atacctaaaa aatactaaca atagaaatat aaaacaaaag cttactacgc
     3361 tcattattag taatttagcc attttgacac cttctttcaa ttatttataa taaacaattg
     3421 acaccaatat tacaattgta atattattaa tttgtaaaaa ttacaactgt aatattggag
     3481 ggtttatttt gaaaaagtta atatttttaa ttgcaattgc tttagtttta agtgcatgta
     3541 attcaaacag ttcacatgcc aaagagttaa atgatttaga aaaaaaatat aatgctcata
     3601 ttggtgttta tgctttagat actaaaagtg gtaaggaagt aaaatttaat tcagataaga
     3661 gatttgccta tgcttcgact tcaaaagcga taaatagtgc tattttgtta gaacaagtac
     3721 cttataataa gttaaataaa aaaatacata ttaacaaaga tgatatagtt gcttattctc
     3781 ctattttaga aaaatatgta ggaaaagata tcactttaaa agaacttatt gaggcttcaa
     3841 tggcatatag tgataataca gcaaacaata aaattataaa agaaattggt ggaatcaaaa
     3901 aagttaaaca acgtctaaaa gaactaggag ataaagtaac aaatccagtt agatatgaga
     3961 tagaattaaa ttactattca ccaaagagca aaaaagatac ttcaacacct gctgctttcg
     4021 gtaagacttt aaataaactt atcgcaaatg gaaaattaag caaagaaaac aaaaaattct
     4081 tacttgattt aatgttaaat aataaaagcg gagatacttt aattaaagac ggtgtttcaa
     4141 aagactgtaa ggttgctgat aaaagtggtc aagcaataac atatgcttct agaaatgatg
     4201 ttgcttttgt ttatcctaag ggccaatctg aacctattgt tttagtcatt tttacgaata
     4261 aagacaataa aagtgataag ccaaatgata agttgataag tgaaaccgcc aagagtgtaa
     4321 tgaaggaatt ttaatattct aaatgcataa taaatacggt tctgttgcaa agttgaattt
     4381 ataatataat tttaacaaaa aggagtcttc tgtatgaact atttcagata taaacaattt
     4441 aacaaggatg ttatcactgt agccgttggc tactatctaa gatatgcatt gagctatcgt
     4501 gatatatctg aaatattaag agaacgtggt gtaaacgttc atcattcaac gatctaccgt
     4561 tgggttcaag aatatgcccc aattttatat caaatttgga agaaaaagca taaaaaagct
     4621 tattacaaat ggcgtattga tgagacgtat atcaaaataa aaggaaaatg gagctattta
     4681 tatcgtgcca ttgatacaga gggacataca ttagatattt ggttgcgtaa gcaacgagat
     4741 aatcattcag catatgcgtt tatcaaacgt ctcattaaac aatttggtaa gcctcaaaag
     4801 gtagttacag atcaggcacc ttcaacgaag gcagcaatgg ctaaaataat taaagctttt
     4861 aaacttaaac ctgactgtca ttgtacatcg aaatatctga ataacctcat tgagcaagat
     4921 caccgtcata ttaaagtaag aaagacaaga tatcaaagta tcaatacggc aaagaatact
     4981 ttaaaaggta ttgaatgtat ttacgctcta tataaaaaga accgtaggtc tcttcagatc
     5041 tacggatttt ccccatgcca cgaaattagc atcatgctag caagttaaac gaacactgac
     5101 atgatatatt agtgattagc tatatttttt actttgcaac agaaccgttt aaattataaa
     5161 gtttggtatc taactgtgct tgctggatta attcctttta tcccaattaa attctctttt
     5221 ataaaattta ataatgtgaa taatcaatcg cccacagttg aaagtaggtc acacgacttg
     5281 aaccataaca taaataccac caaacctgtt caagagttca caacagatat ccataagttt
     5341 aattgggatt caattgataa tatctgcaca gttatttgga tagttttggt tattatttta
     5401 agttttaaat ttttgaaatc cttattatat cttaaatatt taaagagaca gtcactttat
     5461 ctaaacgaaa atgaaaaaaa taaaatagat acgatacttt tcaaccatca atataaaaaa
     5521 aatattgtga ttcgaaaagc agagactatt caatctccaa taactttttg gtatgggaaa
     5581 tatattattt tgattcctag ttcatatttt aaaagtgtaa ttgacaaaag actaaaatat
     5641 ataatattgc atgaatatgc tcatgctaaa aatagagata ctttacattt aattatcttt
     5701 aatatcttct ctattgttat gagttacaat ccattaatac atattgtaaa aagaaagata
     5761 attcatgaca atgaagtaga agccgataga tttgttctta ataatattaa caaaaatgaa
     5821 tttaaaactt atgcggaatc tattatggac tccgtattaa atattccatt ttttaataaa
     5881 aatatattaa gccattcatt taatggtaaa aagtcattac tcaaaagaag attaattaat
     5941 ataaaagaag ccaatttgaa aaaacagtcc aaattaattc caatttttat ttgtattttt
     6001 acttttttgc tcatggtaat tcaaagccag tttttgatgg ggcaatccat aactgattat
     6061 aattataaaa agcccttaca gaacgatcac caaattttag atgaaagtaa aaattttggt
     6121 tcaaatagtg gatctttcgt catgtacagc atgaagaaag acaaatacta tatttataat
     6181 gaaaaagaaa gtagaaagag atattctcct gattcaactt ataaaattta tttagcgatg
     6241 tttggacttg accatcatat cataagtgat aaaaattcac gtatgtcatg gaatcataaa
     6301 cattatcctt tcgagtcttg gaataaggaa caagatttaa atacagcaat gcaaaattca
     6361 gttaattggt acttcgaacg tattagtaat caaataccaa agaactatac tgcggctcaa
     6421 ctcaagcaat taaattatgg taatgaaaac ttgggaagtt ataaaagcta ttggatggaa
     6481 gatagtttga aaatatctaa tcttgaacaa gtaatagttt ttaaaaatat gatggaacaa
     6541 aataaccatt ttagtaaaaa agcaaagaat caattatctt cttcattatt gattaagaaa
     6601 aatgaaaagt atgaactgta tgggaaaaca ggtacaggta tagtaaacgg gaagtataat
     6661 aatgggtggt ttgtaggtta cgtaattaca aatcatgata agtattattt tgctacacat
     6721 ttatcagatg gaaagccgtc tgggaaaaat gctgaattaa tcagtgaaaa aatattaaaa
     6781 gaaatgggtg ttttaaatgg ccaataagca agttgaaata tctatggctg aatgggatgt
     6841 tatgaatata atatgggata aaaaatcagt atcagctaat gaaattgtag ttgaaattca
     6901 aaaatataaa gaagttagcg ataaaacgat tagaacatta atcacaagac tatataaaaa
     6961 agagattata aaacgataca aatcagagaa tatttatttt tactcatcaa atattaaaga
     7021 agacgatatt aaaatgaaaa ctgctaaaac ctttcttaat aaactgtatg gaggggacat
     7081 gaaaagttta gtgctgaatt ttgcgaaaaa tgaagaatta aataacaaag aaattgaaga
     7141 attgcgagac attttaaatg atattagtaa aaagtaatta gagatatgtt tcaaacataa
     7201 tacatatgta aactatgctt gactcttatt aaattagttt tgttaataac atttaaaata
     7261 ttttattaaa tatgagagtg tccagaaaat aaccattttc tatacactct ctttttatgt
     7321 ctatatatat agcaagtata catattttag tgttcaataa cccaacagaa aatctatgtt
     7381 cataaatatg gttagaatta agttatgata caatgaagat gtatatagga ggtttgtatt
     7441 ttgaaaatag gttatgcaag agtttcaact ggtttacaaa atttaaattt gcaggaagat
     7501 caattaaatc aatatggttg tgaaaagata tttagcgacc acataagtgg atcaaaaagt
     7561 aaacgtcctg gtttagataa agccattgaa tttgcgaggg caggagatac gattgttgtt
     7621 tggagactag atagactagg gcgtaatatg gaagatttaa tcacattagt taatgaactt
     7681 aataatcgag gcgtgagttt tcatagttta gaagaaaata taacaatgga taaatcaagt
     7741 tctacaggac aattgttatt tcatttattc gcagcatttg cagagtttga acgcaactta
     7801 attttagaac gttcttcagc aggacgaatt gccgctcgtg ctagaggacg ctatggaggt
     7861 cgtcccgaaa aattaaataa acaagattta aagttactca aaacacttta tgataatgga
     7921 acaccaatta aaactattgc agaacaatgg aaagtttcac gtaccacaat ctatcgttat
     7981 ctcaataggt taaataatca agaaaataaa gataaataat attactaagt tttaagaaag
     8041 ataaaaatag acaggacaca ccctaatcat acaaacagtg ttgttgattt tatagcaact
     8101 aaaacgtatg attagggtgt atgttaatta tggggtgaga accaatgatt gttggctatg
     8161 cgagggtatc atcgcttgat caaaatttag aaagacaact agaaaattta aaaacgtttg
     8221 gtgttgaaaa aatatttaca gaaaaacaat caggaaagtc ggtagaaaat agacctattt
     8281 tgcaagaagc acttaatttt gtaagaatgg gcgatcggtt tgtcgtggag tcaattgatc
     8341 gtttaggacg taattatgat gaagtaatca acacagttaa ttatttaaaa gacaaagaaa
     8401 ttcaattgat gattaccagt ttacctatga tgaatgaagt gattggtaac ccattattag
     8461 ataaatttat gaaaagctta atcatccaaa ttttagcaat ggtttcagaa caagaaagaa
     8521 atgaaagtaa acgtagacaa gaacaaggta ttaaaattgc gaaagaaaaa ggtgtgtata
     8581 aaggacgccc tttattatat tcgcccaatg cgaaaaatcc tcaaaaacgt attatttatc
     8641 atagagttgt agagatgttg gaagaaggtc aagcaattag taaaattgcg aaagaagtga
     8701 atataacaag acagactgtt tatagaatta aacacgataa tgacttgatt taataaactt
     8761 tacttcgatg taaatgagag cttctcatag cgtcccaaaa cggatgataa taatcgatta
     8821 tgagctttta aagacaagaa aagagagtgc aaatatgctc tctctttttt ctatattctt
     8881 tttctcaata acgttcgttt ttgagactag aattttatgc cctacttact tcttttattt
     8941 tcattcaaat atttgcttgt atgatgagtc gaaaatggtt ataatatact caaataaata
     9001 tttgaatgaa gatgggatga taatatgaaa aaaaaagata cttgtgaaat tttttgttat
     9061 gacgaagaaa aggttaatcg aatacaaggg gatttacaaa cagttgatat ttctggtgtt
     9121 agccaaatgt taaaggctat tgccgatgaa aatagagcaa aaattactta cgctctgtgt
     9181 caggatgaag agttgtgtgt ttgtgatata gcaaatatct taggtgttac gatagcaaat
     9241 gcatctcatc atttacgtac gctttataag caaggggtgg tcaactttag aaaagaagga
     9301 aaactagctt tatattcttt aggtgatgaa catatcaggc agataatgat gatcgcccta
     9361 gcacataaga aagaagtgaa ggtcaatgtc tgaacaaaag gttaaactaa tggaagaaga
     9421 aatgaacgtc tatcgggtcc aaggatttac atgttcaaat tgtgcaggaa agtttgagaa
     9481 aaatgttaaa aagattccag gcgttcagga cgcaaaagta aactttggcg cttctaaaat
     9541 tgatgtatat ggaaatgcat cggttgaaga acttgaaaaa gcaggtgctt ttgagaatct
     9601 aaaagtatct cctgaaaaac tagcgaatca aacgatacaa agggttaaag atgacactaa
     9661 ggctcataaa gaagagaaaa caccatttta taaaaaacat agtacattgc tgtttgccac
     9721 actactaatt gcttttggtt acctttctca ctttgtaaat ggagaagata acctcgtaac
     9781 ttccatgtta tttgtaggtt ctattgtaat tggcggatat tcattattta aagtcggttt
     9841 tcaaaatttg atacgctttg atttcgacat gaaaaccctg atgaccgttg ccgttattgg
     9901 agctaccatt attggtgaat gggcagaggc atctattgtt gttattctct ttgcaatcag
     9961 tgaagcactt gaacgcttct ctatggacag agcaagacaa tccatacgtt cattgatgga
    10021 tatcgcccca aaagaagcac tagttagacg aaatggtcag gaaataataa tccatgtgga
    10081 cgatatcgct gtgggtgata tcatgattgt caaaccaggg gagaaaattg ccatggatgg
    10141 aatcattgtg aatggcttgt cggctgtcaa tgaggcagct ataacaggag aatctgttcc
    10201 cgtctccaaa gcggtagatg acgaagtatt tgcaggtacg cttaacgaag agggactaat
    10261 tgaagtaaaa atcaccaaat acgtagaaga tacaaccatt gccaagatta ttcatcttgt
    10321 tgaagaagca caaggggagc gtgctccagc ccaagcattc gttgataaat ttgcgaaata
    10381 ctacactccg atcattatgg ttattgcagc cttggttgca gtcgttccac ccctattctt
    10441 tggtggcagt tgggatacat gggtttatca aggattagca gttcttgtag ttggatgtcc
    10501 ttgtgcatta gttatttcta ctccaatctc gattgtctcg gcaattggaa atgcagcgaa
    10561 aaaaggtgtg ttggttaaag gtggtgtcta tctcgagaaa ttaggagaca ttaagacagt
    10621 cgcatttgat aaaacaggaa cactgacaaa aggtgtacca gtggtaacag attttgaagt
    10681 attaaatgac caagtggaag aaaaagagct attctctacc attacagctt tagaatatcg
    10741 ttcacaacat ccacttgctt cagcaataat gaaaaaggca gagcaagata atatccctta
    10801 ttctaatgta caagtggaag aattcacttc gattactggg cgaggtataa aagggattgt
    10861 aaacggaact acttactata ttggaagccc aaaacttttc aaggaattaa atgtttccga
    10921 ttttagcctt gggtttgaaa acaatgtaaa aatcctacaa aaccaaggaa aaacagccat
    10981 gattattgga acggaaaaaa caattctcgg cgtaattgcc gttgcagatg aggttcgtga
    11041 aacaagtaaa aatgtgattc aaaaacttca tcagttaggt atcaagcaaa caattatgct
    11101 gacaggtgat aatcaaggta ctgcaaatgc aatcggtaca catgtaggcg tttctgatat
    11161 tcagtctgaa ttgatgccac aggataaatt agattatatt aaaaaaatgc aatcggagta
    11221 tgataatgta gctatgattg gcgatggcgt taatgatgct ccagcacttg ctgcatctac
    11281 tgttggaatt gcaatgggcg gtgctggaac agatactgca attgaaacag ctgatattgc
    11341 attaatggga gatgatttaa gtaagcttcc atttgcagta agactcagtc gaaaaacttt
    11401 aaatatcatt aaagctaaca tcacttttgc tatcggaatt aaaataattg ccttactatt
    11461 agttatcccg ggatggttaa ccctttggat agcgattctt tccgatatgg gagctactat
    11521 tttggtagca ttaaatagtt tacgactgat gagagtgaag gataaatagg tagaaaacag
    11581 ggttatgttg caaagtaaaa aatatagcta accactaata tatcatgtca gtgttcgctt
    11641 aacttgctag catgatgcta atttcgtggc atggggaaaa tccgtagatc tgaagagacc
    11701 tacggttctt tttatataga gcgtaaatac attcaatacc ttttaaagta ttctttgccg
    11761 tattgatact ttgatatctt gtctttctta ctttaatatg acggtgatct tgctcaatga
    11821 ggttattcag atatttcgat gtacaatgac agtcaggttt aagtttaaaa gctttaatta
    11881 ttttagccat tgctaccttc gttgaaggtg cctgatctgt aactaccttt tgaggtttac
    11941 caaattgttt aatgagacgt ttgataaacg catatgctga atgattatct cgttgcttac
    12001 gcaaccaaat atctaatgta tgtccctctg tatcaatggc acgatataaa tagctccatt
    12061 ttccttttat tttgatgtac gtctcatcaa tacgccattt gtaataagct tttttatgct
    12121 ttttcttcca aatttgatat aaaattggtg catattcttg aacccaacgg tagaccgttg
    12181 aatgatgaac gtttacacca cgttccctta atatttcaga tatatcacga taactcaatg
    12241 catatcttag atagtagcca acggctacag tgataacatc cttgttaaat tgtttatatc
    12301 tgaaatagtt catacagaag actccttttt gttaaaatta tattataaat tcaactttgc
    12361 aacagaacct ttttttgaga taaatgttta taacgatagt attgtggtag ataacaaata
    12421 taggaagtca aagtaactca catattaaaa aattaacttg aaaggatctt gttataatga
    12481 gttttgtaga taaagcaaaa gatgcagctg aaaaatttaa aaatagtgat aatgaacaag
    12541 taaataaagt aaaagatcaa attaatgaat acactggtgg agaaaaacac gataataaag
    12601 acaaaaaaga tgacaaataa ttgattttga gtgatgactg agttcatcac tttttttgtt
    12661 ttaacctaaa ctaataaaag gctgggattt aggcactgaa cccttaaaat gggaacttaa
    12721 taaaaacact atgttctagg ctgctaattc tctgtatttt acaggggata agtagcctag
    12781 tttttgttga attcgattat tattatagtt tttaatgtat ttttcgacaa tatctattac
    12841 aatatgatta gagctattaa gctgattatt gatgtaaaaa gtttcagatt ttagcgagga
    12901 atggaaactt tctatcgggg cgttatcggc atattaatta ataaaaaaat aaatgactcg
    12961 ataatctata tataaaaatt atcgagtcat ttattttact tccagaacca gttataatct
    13021 attggtttcc tcaattattt ttcttaattc ttcaatagca caaattcttt ccattatatt
    13081 tctctccttt ttctttacat aattaactaa ttatcagaag tttaattcac attaaaagag
    13141 gctgagacat aattcctagc ctttttttat tttaaatata aacatataac atgttacctt
    13201 atttaaacat tatagaagta actaagagag tcacaccaga cagacaaatt gaagttatac
    13261 atattactat gaaaggttta agtgcctttg aaataacttc ttttaaaacg atattcaatc
    13321 ctagagcaac catcgccatt aacatacata ccgttgtaat aacatttata atattcataa
    13381 gtaatgaagg aataggaata aatgtattga cacaagccat taagataaag ccaatgagaa
    13441 aataaggaat atcgactttt tgttgtactt gacttgagtg tgacttataa cgcatataca
    13501 aaattaagac aatgcttaat ggaataagta aaaacacacg gcctaatttt ccaagtaaag
    13561 caaatgtcat tgcctctggt ccgccaatat ctgctgctaa gacgacatga gcgatttcat
    13621 gtaggctgat acctgtccaa gcgccataag ttatagtagg tatgttaaaa atagccttga
    13681 tagctgtata aataagtgca aatatagttc caattagtgc aataatacct acacttattg
    13741 caatgtcttt ttctttagat tttaagattg gtgctgtagc tgcaatagct gcagcaccac
    13801 atactcctgt accaatacca agtaatatag agatatcttt atttccttta ataatttgat
    13861 tcaaaattaa agttaaactt attgaaaaga taattacgat aatatcaata agtagtaatt
    13921 tccagccctt acctaagatg tcccccatgt ttagttttaa cccatataag ataatcgcaa
    13981 attttaataa acgtttcgat gcaaacgtaa tgcctggacg aatatgttca ggataaccta
    14041 tgacttggcg gtatatcatc gcaaaaatga tagcaatagc taatgcccca atcgtatgta
    14101 aaataggaaa ttcagctaat atataactga tcattgcgat tataaatgta aacataatac
    14161 ctttcataaa tgaaggctgc gttattgatt tcatatgtac gttcacctcg atataaaatc
    14221 ttagcacgtt attgttataa cgttaaataa attattagta tagtatatat atcaaaaatg
    14281 ttatattaaa cttaaaggag aatgatgcat ggatccgtac aaggtattaa ttgaagtaat
    14341 gaaaacagaa agctttacta gagcagcaga acatttatat acttcgcaac cttctgtgag
    14401 tcgtgatatt aaacgtttag aattaaaata tcatgttaaa atatttgaat ttaaatctcc
    14461 ctatttaaaa ttaactagag atggcgaaaa gctattacaa tatgcattgc agcgggaaag
    14521 tattgaacaa gaattatggc aaaacttaac atcggaatct gagatcatct caggtacttt
    14581 aacaattgga agcagttata catatggtga atatttatta tcaaaacagc ttaccagtct
    14641 tatgcaacaa tatcctaagt tacatattca tttacgtgtt aataattcag attctgttat
    14701 aaatgatatt aaacacaaca gagtagatat aggtattgta gaaaaggaaa ttcaagataa
    14761 tgcaatagaa tgtaagaaaa taatggaaga cgaaatggtg tatatttaca aaaagtcgct
    14821 tcaacctaga atggatatat gtttcgttag agaaaaaggg tctggaacaa ggttttatca
    14881 ggaagtaggt ctttctgagt tgaaattaaa tccatatttg gtagaaatta ataatattaa
    14941 gattatcaaa caaatggtag aagctggaaa tgggtttgcg attatttcaa aatcagcaat
    15001 tcatcccgag gattatgaaa aattaatgat aacaacttta aatgtgaaac gtcgctatta
    15061 ccttgctcaa catgttgata aatatattga taaaaatatt agaactgtca ttgaaatgat
    15121 tatgaagtag agtatataaa aaagccgaga ctaggaattg gactgacccc aattagttgg
    15181 aattacataa aaacactttc gttgaattca tattaaaatg aatcatacgg aggtgttttt
    15241 attttatttc cacaaatcgg agtcagttca taacttataa gtttctttta aatagtttat
    15301 aagtctaaag ctaaaataca acaactgttg aagatagtaa gcgtgagaca aatttaatat
    15361 tctttatcta taggattgaa tatatccgta tttccacctc gttcttgcac aattttagat
    15421 gctacttcgt ttccccatat acaagctttt tcaatacttt ggttatctag caaacctgct
    15481 gtgtgtgaat caccagcgcc tatagtatca gttacaggaa tcttttcccc ctctaaaatc
    15541 ttaactttac acttatttgc tataagagta ccttcgttgc ctaatgtaac tatcacaggt
    15601 tgattagtct gtttacttac ttctaatgcc gcatctttca catgattctc actactcaat
    15661 tgtaatattt catcttctat atacaatata taccatgtat ccggtgtata tattgtatac
    15721 acgtataacc tacataaaaa tcaaaatata gaacaatgat atataaaaga tgaataaaca
    15781 ataattataa gtaaaaggct taaacgttga tttaataacg tttaagcctt tgtttacagt
    15841 taacataatc ggtgattatc agaagtttca tcactataaa aggtgtatca aagatttata
    15901 ctcccttgat acacctttta cattcatttt taattaccga agaatcgact ccaaaatccc
    15961 tttttaggtg gttctacctc cctattatca tcagaatcac tcttcgtttc ttcaacgaac
    16021 ttatcctctt ttgttaattc accttcatct gtactgtcat tctttttctc ttcggctata
    16081 tccttgtaat ttacttctgt tggttgacgc tttgtttgtt gttggttgat attttgcgat
    16141 tcttcagtaa aagttgcttc ttgcggatta atattttgtc tattattcgt cgctgtatca
    16201 aaagaataat taagctgtct ttcttcttct aattgacttt ctagtttttg aattttttta
    16261 ttgctttcta aagctaatat ttgttgattc tccaacaatt tatttaatgt attaacattg
    16321 ctattttgtt gatctaattg cttagttaaa ttctcaatat atttttcatc atttttagct
    16381 ctagtttcaa agatttctat ttgcttttct aattcgttta cttttgtttt taatgtctca
    16441 gaactatttg aattattata tatattcttt tctgcttttg cagtattttc accaaacaat
    16501 tcttttttta ctgattcttt attttggatt gtactctctt tcttagtaat tttttctata
    16561 attttcaaat aatcattatc atcaatataa ttaatcccat tttctttttc aaaagttata
    16621 tttaaacttt tagcattatt aacaatagtt tgtttagtta cacctaattc atcagcaacc
    16681 attttaatag ttctcataac atccaccctt aggcacctaa tttagtacct aaattttacc
    16741 acctaatgaa gtttatttca tcaattacca ctaaatttac tacctattta ctacatatgc
    16801 acctaattag ctacctataa tatgtttttg aagcttaatt aggtactaaa acaatgaact
    16861 acacattttg ccatggcaat gtgcttttaa ctacatttaa aactctttat atactttctt
    16921 aaaagtgtta atattgcttt ataaatacta aaagagtcaa tgctattggc gtagcattga
    16981 ctctcggtaa taaaacgatt cgcactcgtt tgtttatata ttttttgata cttgtattat
    17041 atctatctaa tcatctaagt gcaagcacaa aacatataac ttacgtaaaa attgttttat
    17101 tacctcaatc ctaaaaatgg aaatgaggtt tttattatgc ccaattttga aaaatacaat
    17161 ttatcacaag taaaaactga aaggttttat caactaccta aatatttatt cgaagatgca
    17221 tattttaaaa aaatgtcggc ggaagccaaa attatgtatg cgttattaaa agatcgcttt
    17281 gaattatcca tccaaaatga atgggtagat aaaaataata acatttactt tattttcagt
    17341 aataaacatt tgtgcgaata cttaggttat gcagaacaaa aaattataaa attaaaaaaa
    17401 gagttaataa gttttaattt actaactcaa gaacgtgttg gccttaataa accaaataga
    17461 ttatatttat taaaacctaa ttatgacatt aaagccagtc atagcaagga acttccaaat
    17521 tcacagttcc agaacaatga atttggaagt tctagaactg tgaatttaag tggtcaagaa
    17581 cttccaaatt cacagtctaa tgatactgag aataatgata ctgattatat taagactgag
    17641 agtaatgata cgaatgattt gaatgataat aaactaactt ttcctagtaa tcatacaaat
    17701 cattcaaatc acgacaattc aaactttaat aatgaagctt taaaattcca attactcgaa
    17761 gaattaccac aaagtattaa aaactatcta agtaactttg aagtagctga aattaaaatt
    17821 atcaaaactg tattattaaa agccaaaaca tctttcaata atgcgattga tagctactac
    17881 ttgttagaag atatggaaat agaaatactt catgttctta aacgtttcaa agctatgctt
    17941 attcaaaaaa atgaaactgt tgaatcaatg caaggatact taatgaaatc tcttaagtct
    18001 gaattcgctg aaatgcatac gcttaataaa cgacgtgatc atttacccat cacttcttta
    18061 tttaatcaat aatgattgat ttagagagca tctttaaata gatgttctct tttttttact
    18121 aacaggtggt tgctaaggca accacctaga tcaaacgaaa ggtaagggag gagataacaa
    18181 aataacatca atacaatttc acaacatagc atgctgctat taaagaaggg aggaacatat
    18241 atgagtaata agaaaaagat taaagttaca ttggcaatga ttaatgttct tttaactgca
    18301 gtcgaacttt atcttcaatg gcaattgagt aaatctgaaa atgaactgta gttaagcaag
    18361 taggtggggc taaaacgttt ctgttttagt cctatttttt ctataaacgg ttattattcg
    18421 tttaaaaatg gctcaaacat gtcgcataag atgaaaaata aaatgatcat ttagcgttgt
    18481 tttaactttt aaaaatgtaa aaatggttaa catttttata ttctttagca atctttctta
    18541 attataaaag tgacttaaaa aaacgtttct gtcatttatt ttgttaatga ttggaaagaa
    18601 aaagttgaat ttatcattcc ataaaatcaa aattcagatt caattgatat acatcataag
    18661 caaaaagtaa gtcgttaatg ttcaagacat gggttgaatg taattttaaa tttgattttt
    18721 tctatcccaa actaagtaac tatttttact tagttttctc tttttttatc tccaattatt
    18781 ttactaacaa tgcttatttt gaaaataaaa ataagcactt aaagtaaaaa gtaaagaaaa
    18841 aaatagctac ttttgtcttc agaaatgttt tgtttttgga aatattacaa acatgagagt
    18901 ctttttaaag agtatttaac atgagcataa ggaaatctag taccaccttt ggtggtattc
    18961 agcatagctg aaagatttac cttttattca ttatgctcaa ttgttcatca taaatagctt
    19021 aaaagcttta tatacaggtg attataagta ttcttataca ttgaacttta gagtgtaata
    19081 taacacttta atacagactc tttacaattg ttacaagacc acttttaatt gtctgaatac
    19141 tccttttttt gttgatttca taggcctcag tcgacgtcga gactcttaag agtcttaatt
    19201 tttttaacca aagactctga agactcctac ttttagtatt aatttcaaca ggaaaatcac
    19261 taaaaaagta atctaagcaa ttcatacatt tgtttcactt tttgaaattg attaaatact
    19321 tttttctcaa tatcaaactc aataatgatc atattattta ttttttaagt tcaaaaaaag
    19381 agaaagaata aaacaatttc tatacgtttc tatgctcaat tttattaaaa agtgaatcga
    19441 aataaagatc attttatctt tttattaact agagaattaa aaaatataaa atgtataata
    19501 agattcatcg aaatgattat actcaaaatt ttttatttta agcttcctaa aattatttta
    19561 attaactata aaatgttaat tgaaaaacag agtattattt attttagact gtctaaagaa
    19621 ataaaataga acggaaaaca tgccaaatta cattttctaa aagaaagtga tttgacagta
    19681 tatttttata tttggaataa aaagagtatt taacgagtga actttttgat ttaacagaaa
    19741 gtgaaaaaca agaaattaat catcaagtga ttgatgaaat tgaagaagaa aaataaaaat
    19801 aaaagcataa agtgagaaat gaataaaatt attgaatttt gttgtttata acaatttctt
    19861 tttttcgcta aacttaatat atttttaact aaattaagtg tcatattttt aggatgaatg
    19921 atatataata ttttatataa tattaaaaca aaggagatta aattatgaaa aaagttactg
    19981 gtttggtagt aagtattgtt tttttaatta ctttatctgc ttgtggagct gaaaaaacta
    20041 aaacatttgt tggagaagaa tctaatgtga aaatggagat aacttataca tataaagggg
    20101 acgaaataat taaacaaaaa tctgtaaata ctttgaaata tagcgatttt agtctgaatg
    20161 atgatacatc taaaaaaata atgaaggaag caatagagaa agaaagtaaa aaaatgcaag
    20221 acgttaaagg tgtaaaggaa actgttaaag agaatgatga agggattgta gaaactataa
    20281 ctatagattt aaaaaatgct gatattgata ctttaaaatc taaagatatt gttagtatgt
    20341 ctggtaatac agggaatggt tttagtatga agaaaactga gaaggaaatg aaaaaagaag
    20401 gttttaaaga aaaagaagac taattttgac tgaatatatt ttatacactt ggaataacgt
    20461 tagcaaaaag ctggcgttat tttttatttt taatgacttt tataattaaa atgttcaaca
    20521 ggaatgattg ctcaaatttt ccaaatatcg ccttaaaatt aaaaataaag gtattctgat
    20581 ttgtaataaa ttagaatata aaaaagagct accatttaaa atttaagtag ctcttactca
    20641 ctttttggct gattaaaaag tggcaaagta ttaaaaatca agaaagaata ttttaattat
    20701 aacatggcag ttatgacgag aaaatttatt gatcgttgag aagaaccctt aactaaactt
    20761 gtagacgaat atcggtatag cgtgagctat taaaccgacc attcgacaag tttagggatt
    20821 gtcaaggatt ccgaggatca acgtcaataa agcaattact tttaagatag attattattt
    20881 tcaaataatt gttttgaaat ttcttttgct tgtttaagat ttaatatttt atgagattct
    20941 ttatttggca aactatttaa atagttttcg gcgttatttt tgcttgtgaa aaagtgtatg
    21001 taaggacagc aatttttgtc acaatcttct ttttgacaaa catctttgta tgaaatgtaa
    21061 atattacttt tgttgtgatt gattatttta ttatctttta tttctagctt aattttttct
    21121 ttagttaatt cgtcttcgct taaaattaat atgtttaagc ttgttgtata atatatacct
    21181 atggcgtcta ttgcacacat tgcaaataag ggttctttgc ttttgtttgt atagacgagt
    21241 ttatttgttt tttcagaaga tataggatat atacatttga ttttatcatt ttcagtagtt
    21301 ataacttttt tgtctattaa agatttatat tcagggatta catctaattt tttattaggg
    21361 ttttcacaaa ttttatttat gatattattt cttaattcgt tttctttttg atttaaatct
    21421 tttgtaaagt tcaattttct gtctccaatc gtaattatta cgatttgatt atacatgaaa
    21481 tttctttttt agaaacgtgt ttcttcttat cttgatacta taaaaaaagc aaagatataa
    21541 cataaaatga cttatcggaa gtagatatgc ttgtatattc acagatggta taataataga
    21601 gtcgcctatc tctcaggcgt caattgacga agagaggagg tgcattactt tgctaatcat
    21661 tttcgttcac atcatagcac cagtcatcag tggctgtgct gttgcgtatt atacttattg
    21721 gcttagtaaa cgcaacaaat aattaatagg cgactttata agccagcatc gaaaaaatcc
    21781 ccacactatt gcagtagtgt ggggattggt gcattaattg ttaatcattt tcgttatcta
    21841 gattataaca ctgttgagta gagaaatgca aaattagtat ctatatagga ggatgaaata
    21901 aaatagagag ttttatagga tttctaacaa tctttttctt tgcaacagaa ccataaaatt
    21961 aaagcgaaaa aaggacgtaa aatagaatgg ctagagttta cttttgatgc tgagaaacgc
    22021 atccatagta agcgacaacc tcaaatggcg aatgtaggcc aacccaaaca atatatcagt
    22081 cgagaaaaaa cgccaaaatg gctacatgaa aaaaatcaaa acaatacaac tagagaaatg
    22141 actgaagaag aaaaagcact attaaaagaa caacaacaag catttagaca acaattagaa
    22201 ctagattggg aagattagaa agtttacaaa agataacatg aaagatatac tgaagttaac
    22261 aaacagacag atacatcatt agatgtgaaa accccagcat gccgaccaaa gcatatgctg
    22321 gggtttcttt tttatcgttt atgttcttga tttaataaat aaagaacacg cccaacaata
    22381 attggacata cgatatactt cataacaaac agaacgacaa tcattagatg tggcacctcc
    22441 tttctgcacg gaagtgctct ccaattataa caaaatccct atgacctgta tgcgtgcata
    22501 caatatgcaa gcatactgtg tgcacgcata ttgtatgtaa catctaaata cgatatatca
    22561 attacaggta aagagtccgg gacataattt atcccttata ggtagttagt ttgtatagcc
    22621 tagtcatctt tattttcttt tttattatct ttttcgattt ttttatctat aaagaagaaa
    22681 cagataatta taataaaata aatagcaaag aaaatagttt tgccatatgg aatatgaaaa
    22741 atagcgataa aaattattga atacacgctc aatgatatca aacaaatatt taataataaa
    22801 ttatactttt ttaatttatt ttttttcatt tttaattatt tccccttttt ttattatgtt
    22861 attactttat atgtaataaa tttatagaaa atggaggaat tattatgaaa aatttggttc
    22921 tgttgcaaag ttgaatttat aatataattt taacaaaaag gagtcttctg tatgaactat
    22981 ttcagatata caatttaaca aggatgttat cactgtagcc gttggctact atctaagata
    23041 tgcattgagt ggttctgttg caaagttgaa tttatagtat aattttaaca aaaaggagtc
    23101 ttctgtatga actatttcag atataaacaa tttaacaagg atgttatcac tgtagccgtt
    23161 ggctactatc taagatatgc attgagttat cgtgatatat ctgaaatatt aaggggacgt
    23221 ggtgtaaacg ttcatcattc aacggtctac cgttgggttc aagaatatgc cccaatttta
    23281 tatcaaattt ggaagaaaaa gcataaaaaa gcttattaca aatggcgtat tgatgagacg
    23341 tacatcaaaa taaaaggaaa atggagctat ttatatcgtg ccattgatgc agagggacat
    23401 acattagata tttggttgcg taagcaacga gataatcatt cagcatatgc gtttatcaaa
    23461 cgtctcatta aacaatttgg taaacctcaa aaggtaatta cagatcaggc accttcaacg
    23521 aaggtagcaa tggttaaagt aattaaagct tttaaactta aacctgactg ccattgtaca
    23581 tcgaaatatc tgaataacct cattgagcaa gatcaccgtc atattaaagt aagaaagaca
    23641 aggtatcaaa gtatcaatac agcaaagaat actttaaaag gtattgagtg tatttacgct
    23701 ctatataaaa agaaccgcag gtctcttcag atctacggat tttcgccatg ccacgaaatt
    23761 agcatcatgc tagcaagtta agcgaacact gacatgataa attagtggtt agctatattt
    23821 ttttactttg caacagaacc tcccaaagtc ttatttgggg ctctacactc ataaatttag
    23881 aaagggcttg agcgttgtct cggttgagat ttccaacgat cgtcattgca tcaaaactta
    23941 attttggatc agatatgcac acagtatgtg cgtccaaccg gctattagag tagccggttt
    24001 tagaaaaatt gtctaaatcg tgattttcca aatgatttga atgatttgca tgattgtttt
    24061 tatacataaa aaatcgactc cttaatctca atttcgttta aggaatcgct cacccaaata
    24121 tatatcttga tgtatattta aatatcgttt aatatctaaa tatacaagat tataaaaaca
    24181 actcagtgtt tttttctttg aatgatgtcg ttcacaaact ttggtcaggg cgtgagcgac
    24241 tcctttttat tttgttatta atataacact atcaaaagac ttggtctaat cagatcaagt
    24301 ctttttttat ttaagcattt gtattatctg gtaaacagtt aaaactacta aaacaccaag
    24361 tacatactta cttgttataa aattctcaaa ggcttctctg aatttcattt cttcaactcc
    24421 ttttattgct ttattccaat ttccttattg gtcggaacct acagggcttt atgtgttgtt
    24481 gagttggtac tttcttggga ttaatcccaa ttcaagtcca accaactcgc taacaagtta
    24541 gctaacacat agcccattcc aaccaataag ttttctcggc ataaatgcat gttctataag
    24601 tgcatacctc tatctcgttt ttgattcttt tgttgttctt gttgctgttc ctgttctgaa
    24661 tataattctg gattcatttt tttatctaag tttcctgcta aaccatttag ttttggttca
    24721 tcttctgtta acttattaac tctttccgca aaggtatttc ttcctaaaac tcgttctaac
    24781 tcttttagta agatttttaa aagctttaac gctatttcta tattctcttt aagtggcttt
    24841 gcattttcgt aaagttggtt aaaattatcg tctgcgtttt caatacgctc aactgcttta
    24901 tttaataaat catctttctc tcgtatttcc ttatctttat catctaaggc tctaccagac
    24961 tttatatact cgtaatcttc cgaaatatct tgagcagctt ttatctgttt ctgaaattca
    25021 ttgaaatctt tttggcttat tacaacattt ccagtttctt gtatttcttt gctaaataaa
    25081 ccacctactt tttcagtttc ttgctcatac ggaacattta taggcttttt aagcgtattt
    25141 aacgattttt ggtactcttg cattaattta tcgttctttt gctttatatg gtctgttttt
    25201 tggctctcac gttcatattc ttgcttatga tattctgttt tttgtttata ctgacttatt
    25261 tgctcatgtt tagcatttgt tacttgtctt gattgcccac gttctaaatc atatcctcgt
    25321 tgtttaacat gctcattaaa tctatcttga aacgctgtta aagctttttt attacctaca
    25381 acttctttag cacttaaacg accatcatca gttattggaa caacgccata atgcatatgt
    25441 ggtgtttttt cgtccatgtg aactgttgca tataataaat tatctttacc gtattcttgt
    25501 tctaaaaact ctttagcata ttcaaaaaac tgctttgtat cttctggcgt ttgattatca
    25561 aagaaatcat tgtctgatgt aattaaacca tcaatgtgtt taatcgcgtc tgttctaatt
    25621 tttcttttgc ctgtataatt ctgttcgatt ttttcatcaa tcaagttatt aaaattctgt
    25681 ttattagcat ttaccaaatc ataatttaag taagttttac tatggtctat atcttcattt
    25741 tcataattat tattttctct ttgaacatgt ttttgtatgc ccgttgtatt tgttccagat
    25801 ttaacttttg aaactctaac aatggaataa gacatataaa aatcactcct aagcacaaag
    25861 gtttcatgtg tatttaatag tttaagtcta acacactaga cttattttta ataagtcgtt
    25921 aatacgtgtg ctctgcgagg cttaaacctg tttttgctaa cgcaaaaaat gagtggcaaa
    25981 atgctagcca ctcatagttc taaaccaaaa tataatataa ctattcaaac tgcttttcag
    26041 aacgtttaaa tacaataatc gtcaaaagac aacataaaat aataaggata gccatggcta
    26101 caagaatatt actatacact ccagaagaat aatttataaa ttccagaact agtttacgat
    26161 taatcaattg tagtgacaat aaacctccta caattgctat acctgttccc tctgataaaa
    26221 aacttgtgaa atttagcaaa ctcattccag aagcaacttc ttcttcagaa agactacttg
    26281 atactatttt tgatataact gttttagtaa aagataatcc gcccataaca aatataaaca
    26341 taaaagtagt caaccacata ctaaactcaa caaaaaatgc aatagttaaa aaacttatag
    26401 agatagacaa tgatcctaaa ataaaaacaa ataatgatcc ttttctatcc actaaaaaac
    26461 caccaaaata accaaaaaca ataacactca tggttccagg aaaaataaca ctattaccta
    26521 ttgtcgctac atttacatga taaatagttt tcatcatata aggcaccatt gatataaaac
    26581 cagctactat agaaaatatt agcccaccag aaaacaaacc aagcataaac ggaatgtttt
    26641 tccctagttt aggattaata aaagggttag aaactcttga aatatgttta ataaaaatca
    26701 caaaaaagat tgtgaagagt attaaaaaag tccaattata atttgtcgta aataacataa
    26761 aacatataat acttatagac attaaaacaa tacctacgat atctaatgta ttttttgttg
    26821 atttaccagg taccattact ttaataagaa aaggtatagt tactattgta atcataggaa
    26881 gtataagtag gtaagaccaa tgaatataat gtgctattat tccccctatt gaaggaccta
    26941 acccttcacc taaagctaca attgatccta taaaaccaaa ggctttgcct tgtttttttc
    27001 ttgtaatatt tctagctaca accaccataa tcagtgaagg gaatgcagca gatcctactc
    27061 cttgtactaa cctaccaaaa atcaaaataa aaaagtgatt gtgaccaata aaagcaatca
    27121 atgaaccaag acagctcaaa ctaataccaa taattaacaa tttttttata tttatataat
    27181 cagataattt tccatatact gctgttccta tcgaaaaagt taacatatat gcagtgttta
    27241 cccagtttgt aattccagga gtagtattaa aatgatttgc aatatcaggt aaagaaacat
    27301 ttaaaaccat ttcatttaat acactaaaaa atgaaagaat acaaagccaa aataaaacgc
    27361 tataaaacaa acctttaaat tttttatata aactaaacaa ttttacctct ttacttgagg
    27421 tgactaaagt ttataggggt aaattattct ttcacctcat ataaattccc caaattttta
    27481 aatagacact tcataaaaaa atcctcctaa attagaatag tttaaatata tcatttttgt
    27541 tcagtaatat taatatgtac actatttcca aaatttaaat tcatgttgcc aaaaatcgat
    27601 ttgtttttgc aattgttttt cgttcgcttt taaagtcgat ttcattaagt ccgttaaatc
    27661 gactggcgaa atttctttta tcaaattctt atattttgtt ctagaatttc tgtgaagctt
    27721 tccccattct tcttcatcac tcaataacat aaaaactatt gctctatccg cagtgcgttg
    27781 gatagttttc caatctggtt gcaagatatg taaatcacta aagcaatcat tccagtaatc
    27841 caccatatct cttttaagtt cgatttctac acgccataaa tgttcagaca taacttcagc
    27901 atctgcatta tctttacgtt cttgcttttt attataaatt ctaataggtt ctgttgcaaa
    27961 gttgaattta tagtataatt ttaacaaaaa ggagtcttct gtatgaacta tttcagatat
    28021 aaacaattta acaaggatgt tatcactgta gccgttggct actatctaag atatgcattg
    28081 agttatcgtg atatatctga aatattaagg ggacgtggtg taaacgttca tcattcaacg
    28141 gtctaccgtt gggttcaaga atatgcccca attttatatc aaatttggaa gaaaaagcat
    28201 aaaaaagctt attacaaatg gcgtattgat gagacgtaca tcaaaataaa aggaaaatgg
    28261 agctatttat atcgtgccat tgatgcagag ggacatacat tagatatttg gttgcgtaag
    28321 caacgagata atcattcagc atatgcgttt atcaaacgtc tcattaaaca atttggtaaa
    28381 cctcaaaagg taattacaga tcaggcacct tcaacgaagg tagcaatggt taaagtaatt
    28441 aaagctttta aacttaaacc tgactgccat tgtacatcga aatatctgaa taacctcatt
    28501 gagcaagatc accgtcatat taaagtaaga aagacaaggt atcaaagtat caatacagca
    28561 aagaatactt taaaaggtat tgagtgtatt tacgctctat ataaaaagaa ccgcaggtct
    28621 cttcagatct acggattttc gccatgccac gaaattagca tcatgctagc aagttaagcg
    28681 aacactgaca tgataaatta gtggttagct atattttttt actttgcaac agaaccatat
    28741 ttcagatata tcacgatagc tcaatgcata tcttagatag tagccaacgg ctacagtgat
    28801 aacatccttg ttaaattgtt tatatctgaa atagttcata cagaagactc ctttttgtta
    28861 aaattatatt ataaattcaa ctttgcaaca gaacc
//
