LOCUS       NZ_CP010366             6914 bp    DNA     circular CON 07-FEB-2024
DEFINITION  Enterobacter hormaechei subsp. xiangfangensis strain 34978 plasmid
            p34978-13.828kb, complete sequence.
ACCESSION   NZ_CP010366
VERSION     NZ_CP010366.2
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN03067415
            Assembly: GCF_000807405.2
KEYWORDS    RefSeq.
SOURCE      Enterobacter hormaechei subsp. xiangfangensis (Enterobacter
            xiangfangensis)
  ORGANISM  Enterobacter hormaechei subsp. xiangfangensis
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
REFERENCE   1  (bases 1 to 6914)
  AUTHORS   Chavda,K.D., Chen,L., Fouts,D.E., Sutton,G., Brinkac,L.,
            Jenkins,S.G., Bonomo,R.A., Adams,M.D. and Kreiswirth,B.N.
  TITLE     Comprehensive Genome Analysis of Carbapenemase-Producing
            Enterobacter spp.: New Insights into Phylogeny, Population
            Structure, and Resistance Mechanisms
  JOURNAL   mBio 7 (6), e02093-16 (2016)
   PUBMED   27965456
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6914)
  AUTHORS   McCorrison,J., Sanka,R., Adams,M., Brinkac,L., Sutton,G.,
            Kreiswirth,B. and Chen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-AUG-2015) JCVI, 9704 Medical Center Drive, Rockville,
            MD 20850, USA
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 6914)
  AUTHORS   McCorrison,J., Sanka,R., Adams,M., Brinkac,L., Sutton,G.,
            Kreiswirth,B. and Chen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-DEC-2014) JCVI, 9704 Medical Center Drive, Rockville,
            MD 20850, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Assembly Name :: HGAP assembly of Enterobacter cloacae 34978
            Expected Final Version            :: Yes
            Genome Coverage                   :: 7.78x
            Sequencing Technology             :: Pacbio RS
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/07/2024 01:42:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,071
            CDSs (total)                      :: 4,956
            Genes (coding)                    :: 4,848
            CDSs (with protein)               :: 4,848
            Genes (RNA)                       :: 115
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 83
            ncRNAs                            :: 7
            Pseudo Genes (total)              :: 108
            CDSs (without protein)            :: 108
            Pseudo Genes (ambiguous residues) :: 0 of 108
            Pseudo Genes (frameshifted)       :: 39 of 108
            Pseudo Genes (incomplete)         :: 70 of 108
            Pseudo Genes (internal stop)      :: 20 of 108
            Pseudo Genes (multiple problems)  :: 20 of 108
            Pseudo Genes (short protein)      :: 1 of 108
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP010366.2.
            On Aug 25, 2015 this sequence version replaced NZ_CP010366.1.
            The organism was changed from 'Enterobacter cloacae' to
            'Enterobacter hormaechei subsp. oharae' in June 2016.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6914
                     /organism="Enterobacter hormaechei subsp. xiangfangensis"
                     /mol_type="genomic DNA"
                     /strain="34978"
                     /isolation_source="bodily fluid"
                     /host="Homo sapiens"
                     /sub_species="xiangfangensis"
                     /db_xref="taxon:1296536"
                     /plasmid="p34978-13.828kb"
                     /geo_loc_name="USA"
                     /collection_date="2011"
                     /collected_by="Barry Kreiswirth"
     gene            1..702
                     /locus_tag="LI63_RS01285"
                     /old_locus_tag="LI63_01630"
     CDS             1..702
                     /locus_tag="LI63_RS01285"
                     /old_locus_tag="LI63_01630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001281399.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_044596214.1"
                     /translation="MSDLIAYKSNALIEASYRLTLQEQRFLLVCISRLKSGEDAPSPDE
                     QKTMTITAAEFHDAFPDMGRQHAEAKLKEAIDRLWDRSVIIKNEEKREEFRWVQYRAQY
                     LKGEAKVEITFSDAIMPYLTQLKGQFTRVVVKNVSSLSSTYSIRIYELLQQFRSTGDRT
                     ISLDDFRSILELEDKYSDFKILNRDLIKPAIAELNEKSDLAVTVETVKKGRTVVALRFR
                     FKEDKQIKMAV"
                     /name="replication initiation protein"
     gene            699..824
                     /locus_tag="LI63_RS27325"
     CDS             699..824
                     /locus_tag="LI63_RS27325"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_257792353.1"
                     /translation="MNTETKKLTLDELLAQCNPDAGMSDEDRQWVNQPPAGDEIA"
                     /name="hypothetical protein"
     gene            839..1102
                     /locus_tag="LI63_RS01290"
                     /old_locus_tag="LI63_01500"
     CDS             839..1102
                     /locus_tag="LI63_RS01290"
                     /old_locus_tag="LI63_01500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_042096185.1"
                     /translation="MNSTTHYENANFLRELAESLPRILPDGGADKAALLQRLANEELAQ
                     AEYDERVRAKVAAARADKRPGMSTAQLRQQLQGRYQELSNDL"
                     /name="hypothetical protein"
     gene            1092..1391
                     /locus_tag="LI63_RS01295"
                     /old_locus_tag="LI63_01495"
     CDS             1092..1391
                     /locus_tag="LI63_RS01295"
                     /old_locus_tag="LI63_01495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010848978.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]; GO:0009432 - SOS response [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_044596213.1"
                     /translation="MTYEIDWRPGAVEDMAALFEYLAENASLWDARNVTDRLIAATERL
                     EDYPRLYETDERYGEGVRRISLLGQHVLYEVNDEARRVNILAVVGQRQNPLSVR"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(1399..1560)
                     /locus_tag="LI63_RS26890"
     CDS             complement(1399..1560)
                     /locus_tag="LI63_RS26890"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_157843873.1"
                     /translation="MTEKKQSANAKRQAAFKARQREAGRIQRVLWLTDEEVNAVKALLD
                     KMRGDERP"
                     /name="hypothetical protein"
     gene            1609..1998
                     /locus_tag="LI63_RS01300"
                     /old_locus_tag="LI63_01490"
     CDS             1609..1998
                     /locus_tag="LI63_RS01300"
                     /old_locus_tag="LI63_01490"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_042096182.1"
                     /translation="MKKLSVYSRLSRKAGAKIYPNSNPDVHLHKADRIIPVRQEYAGAA
                     AATAGRIAVEVERQTLRSMTYKRLYPWVLALSVLCLLPPFASMGVDMFHAKQAQAEMQR
                     QQKQQLEEMNRRQQERINRLRSGIY"
                     /name="hypothetical protein"
     gene            2010..4115
                     /locus_tag="LI63_RS01305"
                     /old_locus_tag="LI63_01485"
     CDS             2010..4115
                     /locus_tag="LI63_RS01305"
                     /old_locus_tag="LI63_01485"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_044596212.1"
                     /translation="MKKLSLNWSGNVGQSIEKARTLAAEYSRRDVPDNAPADLRDSASQ
                     GLETSKGFALSGRLLQSELVYGSDVPLAQFGTVLIPLVLAFTTLLLYWLPAWLAFIPAV
                     LWALFAIMTGGFTLGWFAGVLALLLLWGSDISLFSMGGTAQMLQFGTGMTLTLISLAAL
                     PLCHLLRRAERFTIINDDAKAGAIILSASRQAKAREKQTERAARDTSPLIWLGEAQGVT
                     WEKGDIMAPDPASRVALSAADLSTGLLVLGGTGTGKTSGVFRPVIRQWCEHNCGGLLLM
                     DGKGQLPAELAESNRGITLLTPDNPETPVPLIDGLNAEEVAAVLVSVSGKGNDKGSDWT
                     FAAEKQFRFSALLVELAVSVQAAPWTLATIARCVSDTAFRDTLIEAVSARTETLSPELT
                     TAALDFWLKEYPELAKAEGYTSSVQGIVTAWLSPLVGHRKMHGWINAAEGVNPSDVLLG
                     ARYGIGIDSSVYGELCTAAVNGFIKKRLYNEATRRGDNWKADCTNTAAMIVMDEADVLL
                     DETDAGILPRGRSLGLNFVVGLQAVEQAEAAFGGTQNAPKALAMLAQLRSVVALSSTHH
                     TAQYVSDRVGFGLPLEPVSLSTVPDMRYTVLQRAAASPFNDEENEFRSSITLDIPHVIS
                     HTVGKMMDHKNAAGERLQLAKEPKPWISPQECNMLTATEGVAVVVLNRAGAPRRDAIEL
                     VPEYRAG"
                     /name="TraM recognition domain-containing protein"
     gene            complement(4143..5582)
                     /locus_tag="LI63_RS01310"
     CDS             complement(4143..5582)
                     /locus_tag="LI63_RS01310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011382089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobA/MobL family protein"
                     /protein_id="WP_052683669.1"
                     /translation="MAIARLNMKAGMKGRGADHSAYISREGKYANRLERGERLEATDHG
                     NMPEWAKDNPQQFWLAADAYERKNGTSYREMEIALPRELNSEQREALVRDWTEQELGDK
                     HAYQWAIHVPTAADGGEQPHVHLMFSERQRDGIEREPDQYFKRYNSRNPEAGGARKGYG
                     EHGGQPRTLEQRREELVALRGRWETKANEHLERAGQRERIDMRSYTAQGKDAIPEKKQL
                     PSEWRDERKRAEILDFRAAKAEQEQAQKDAGKVLYEHNSAVEHYRGVVAAVPEHRLKNS
                     SPDSIALDLREKLVGQRVDSDPAVVAAREQEEKTGKALENARQERDKTRQEAEQQRQEQ
                     QRWEEENRMRRWLHDKGIKKDERYTGLQQQREKSEQQAQAAVQKEQQAEMQHRQAVTAR
                     EETETDVRQQANEKWFEHHHTAVKEAAAERQRELERQEREQQQAKQAEYQQLIAQQQRQ
                     REQEKEQEHTPERQHGRGMSM"
                     /name="MobA/MobL family protein"
     gene            5757..6215
                     /gene="traD"
                     /locus_tag="LI63_RS01315"
                     /old_locus_tag="LI63_01475"
     CDS             5757..6215
                     /gene="traD"
                     /locus_tag="LI63_RS01315"
                     /old_locus_tag="LI63_01475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011382088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein TraD"
                     /protein_id="WP_044596211.1"
                     /translation="MHENEWLEKRLAYIRGLSAPNEQQRLLLMLAQLPQPTPNDRRKLG
                     VLIRAEKAAERALKARADAAKVLNAERRAIRKARDHELYKAAGLMGVAGVVDRQTGRLN
                     VDAGLLVGLLMELSAGTLPDSLHRETLKSRGDAAIAAREKKNKTNQAG"
                     /name="traD"
     Typing          2..702
                     /name="rep_cluster_1778"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(4147..5582)
                     /name="MOBQ"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 atgtctgatt tgatagccta caaatctaac gcccttatcg aggcaagtta caggctcacc
       61 ttacaggaac agcgcttcct gctggtctgt atcagccgcc tgaaatccgg ggaagatgcc
      121 ccttcgccgg atgaacaaaa aaccatgacc atcacggccg cagagtttca tgatgctttt
      181 cctgacatgg gacggcagca cgctgaagcc aagctcaagg aagcgataga tcgcctctgg
      241 gacaggtcag tcatcatcaa aaacgaggaa aaacgcgagg agttccgctg ggtgcagtac
      301 cgggcgcagt atctcaaagg tgaggcgaaa gtagagatca ccttctccga tgccatcatg
      361 ccgtatctga cacagctaaa ggggcagttt acgcgggtag tggtgaagaa cgtttccagc
      421 ctctccagca cctacagcat ccgtatttac gagctgctcc agcagttccg cagcaccggc
      481 gacagaacta tttcactcga tgacttccga tccatactgg aactggaaga taaatattct
      541 gatttcaaga tattgaacag agacttaata aaaccggcca tcgctgagct gaacgaaaaa
      601 agcgatctgg ccgtcaccgt cgagacggtg aaaaaggggc gaaccgttgt cgcgttgcgg
      661 ttccggttca aagaggacaa gcagatcaag atggccgtat gaatactgaa accaaaaagc
      721 tgacgctgga tgaacttctg gcacaatgca atcccgatgc cggcatgagc gatgaagatc
      781 gccagtgggt aaatcagccc cctgccggcg atgaaatcgc gtgaatggag atatgaccat
      841 gaacagcact acccactacg aaaacgccaa ttttctgcgc gaactggccg agagcttgcc
      901 ccgtattctg ccagatggcg gcgcggataa ggccgctctg ctccagcgac tcgctaacga
      961 agaactggca caggctgaat acgacgaacg ggttcgcgca aaggttgccg ccgcccgcgc
     1021 tgacaagcgg ccgggcatga gtaccgcgca gctgcgccag cagttacagg gacgctatca
     1081 ggaactgagc aatgacctat gaaatcgact ggcggccggg ggcggttgaa gatatggccg
     1141 ccctgtttga gtatctggcc gaaaatgcct cgctatggga cgccagaaac gtgacagacc
     1201 gcctgatagc cgccactgaa cgactggaag attatccccg tttgtacgag accgacgagc
     1261 gatacggcga gggcgtccgg cgtatcagcc tgctcggcca gcatgtgctg tatgaggtga
     1321 acgacgaggc acggcgggta aacattctgg ccgtggtcgg tcagcgtcag aaccccttat
     1381 cggtacgctg aaaacgcctt acggacgttc atccccccgc attttatcca gtaacgcctt
     1441 gacggcgttc acctcttcat cggtcagcca cagcacccgc tgaatgcggc cggcttctct
     1501 ctgtctggcc ttaaacgccg cctgacgctt ggcatttgct gattgctttt tctctgtcat
     1561 tcgttactat ccgatgcgtt actagtaacg cttaaggagt ggtttctgat gaaaaaactg
     1621 tctgtttatt cacgtcttag ccggaaagcc ggcgcgaaaa tataccctaa cagtaacccc
     1681 gatgttcacc tgcataaagc agatcgcatt atccccgtgc gccaggagta tgccggcgcg
     1741 gccgccgcaa cggctggccg cattgctgtg gaagttgagc gccagacgct gcgcagcatg
     1801 acctataagc gcctgtatcc gtgggtgctg gcgctgtccg ttctctgcct gctcccgccg
     1861 tttgcctcga tgggggtcga tatgttccat gcaaaacagg cgcaggcgga aatgcagcgc
     1921 cagcagaaac aacagctgga agagatgaat cgccggcagc aggaaagaat taatcgcctg
     1981 cgcagcggca tttactgagg gatcagaaca tgaaaaaact gtcacttaac tggtctggga
     2041 atgtgggtca gtccatcgaa aaagcccgca cactggccgc cgaatactcc cgccgtgatg
     2101 tacccgacaa cgcaccggcc gatctgcgcg actcggccag tcagggactg gaaacgagca
     2161 aggggtttgc gttgtctggc cgtctgctgc aaagcgaact ggtctacggt tcagatgtgc
     2221 cgctggcgca gttcggcact gtgctgatcc cgctggtact ggcgttcaca accctgcttc
     2281 tctactggct cccggcatgg ctggcattca ttccggccgt cttatgggcg ctgtttgcca
     2341 tcatgaccgg tggttttacg ctgggctggt ttgccggcgt tctggcgctg ctcctgctct
     2401 ggggatctga tatttcgctg ttttcgatgg gcgggacagc gcagatgctc cagtttggca
     2461 ccggtatgac gctgacgctg atttcgctgg ccgctctgcc gctctgtcac cttctgcgcc
     2521 gcgccgagcg ctttaccatc atcaacgatg acgctaaagc cggcgcaatc attctgtccg
     2581 cctcacgtca ggcaaaagcc cgcgaaaagc agacagaacg cgccgcacgc gacacctcgc
     2641 cgctgatctg gctgggtgag gcgcagggcg tgacatggga gaagggggat attatggcgc
     2701 ccgatccggc gtcacgcgtt gccctgtcgg ccgctgacct gtccacggga ttgcttgtgc
     2761 tcggtggcac cggcaccggc aaaacgtccg gcgtgttcag gccggttatc cgtcagtggt
     2821 gtgagcacaa ttgcggtggc ctgcttctga tggacggaaa ggggcagtta ccggccgaac
     2881 tggccgaaag caacagggga ataacgctgc tgaccccgga taacccggaa acgcctgtcc
     2941 cgctgatcga tggcctgaat gccgaagaag tggccgccgt gctggtttct gtctccggca
     3001 aggggaatga taaaggctct gactggacat ttgcggccga aaaacagttc cgtttctctg
     3061 ccctgctcgt tgagctggct gtcagcgttc aggctgcacc gtggacgctg gccaccattg
     3121 cccgctgcgt gtctgatacg gcatttaggg acacgctgat tgaggcggta agcgcccgta
     3181 cagaaacact gtcacctgaa ctgaccacgg cggcgctgga tttctggctc aaggaatacc
     3241 cggagctggc aaaagccgaa gggtatacca gttctgtgca ggggattgtg accgcgtggc
     3301 tttctccgct ggtcggccac aggaaaatgc atggctggat taatgccgcc gaaggggtta
     3361 acccttctga tgtcctgctc ggagcgcggt acggcatagg gattgattca tcggtatatg
     3421 gcgaactctg caccgcagcg gttaacgggt tcatcaaaaa acgcctgtac aacgaggcaa
     3481 cgcggcgcgg ggataactgg aaagcagact gcacaaatac ggcggccatg attgtgatgg
     3541 atgaagcgga tgtgctgctc gatgaaaccg atgccggcat tctgccgcgt gggcgctcac
     3601 tggggctgaa tttcgtggtt ggcttgcagg ccgtggaaca ggcggaagcc gctttcggtg
     3661 ggacgcagaa cgcgccaaaa gccctggcga tgctggcgca gctgcgctcc gttgtcgcgc
     3721 tgtcatcaac ccatcacacc gcgcagtatg tctccgatcg tgtggggttc gggctgccac
     3781 ttgagccggt atcgctctct accgtgccgg atatgcgcta taccgtactg caacgggcgg
     3841 cggcctcacc gtttaacgac gaggaaaacg agttccgcag ctcgataacg ctcgatattc
     3901 cgcatgtgat tagtcatacg gttggcaaaa tgatggatca caaaaatgcg gccggcgaac
     3961 gtctccagtt ggcaaaagag cctaagccgt ggatctcacc gcaggaatgc aacatgctca
     4021 cggcgacgga gggcgtggcc gttgtggtac tcaaccgcgc cggcgctccc cgccgcgatg
     4081 cgatagagct ggttcccgaa tatcgcgccg gctgaaaaaa aaggcaccgc aaggtgcctt
     4141 ttttacatgc tcattccgcg cccgtgctgc cgttccggcg tgtgttcctg ctctttttcc
     4201 tgctcacgtt gccgctgttg ctgggcgatc aactgctgat attcagcctg ttttgcctgc
     4261 tgctgctccc gctcctgccg ctcaagttcc cgctggcgtt cggcggcggc ctctttcacg
     4321 gccgtatgat gatgctcgaa ccatttttca ttggcctgct gacggacatc agtttcggtt
     4381 tcttcccgcg cagtgacggc ctgccggtgc tgcatttctg cctgttgctc cttctgcacg
     4441 gcggcctgtg cctgctgctc tgatttttcc cgttgctgtt gcagtccggt ataacgctcg
     4501 tcctttttga tgcccttgtc atggagccag cggcgcatcc ggttttcttc ttcccatcgt
     4561 tgctgctcct gccgctgctg ctcggcttcc tgccgggttt tgtcccgttc ctgccgcgca
     4621 ttctccagtg ccttaccggt tttttcttcc tgctcccgtg cggccactac ggccggatcg
     4681 ctgtcaacgc gctgcccgac gagtttttct cgcaaatcca gagcgatgct gtccggtgag
     4741 gagtttttca gccggtgctc cggcaccgcg gccacaacgc cgcgatagtg ctctaccgcg
     4801 ctgttgtgct cataaagcac cttgccggcg tctttctgag cctgttcctg ctcggctttt
     4861 gcagcgcgga aatccagtat ttctgcacgc ttccgctcgt cgcgccattc actcggtagc
     4921 tgcttttttt caggaatggc gtccttgccc tgcgccgtat agctgcgcat gtcgatacgt
     4981 tcgcgctggc cggctcgctc aaggtgttcg ttagctttgg tctcccagcg gccgcgcagg
     5041 gcgacaagct cctcgcgccg ctgctccagc gtgcgcggct ggccgccatg ctcaccgtac
     5101 cccttccgcg ctccgcctgc ttccgggttc cggctgttgt agcgtttgaa atactgatct
     5161 ggctcgcgct caatcccgtc acgctgccgt tcggagaaca tcaggtgtac gtgtggctgc
     5221 tcacctccgt cagcggcggt gggaacgtgg atagcccact gataagcgtg tttgtcgccc
     5281 agctcctgct ccgtccagtc cctgacaagc gcctcacgct gttcgctgtt cagttcacga
     5341 ggcagggcga tttccatctc acggtatgaa gtgccgttct tgcgctcata cgcatcggcg
     5401 gccagccaga actgttgcgg attgtccttc gcccattccg gcatattgcc gtggtcggtg
     5461 gcctccagtc gctcgccccg ttccagacga tttgcatact tgccctcacg ggaaatgtag
     5521 gccgagtggt ctgcgccacg gcctttcatt cccgctttca tgttgagtcg tgcaatcgcc
     5581 atttctttac cctgtaaatt ttggggtgtg gggcttgccc caccgcgcag tttctcaccg
     5641 aaggagagaa actactaagc gcgccttccg aaaatcgaag atttccgaga aggatacacc
     5701 ctccgccgca actgtggtag ttttatgcag gcacgaaacg aaaagcgggg gaaaaaatgc
     5761 acgaaaatga atggctggag aaacggctcg catatattcg cggactgagc gcaccgaacg
     5821 aacaacagcg ccttttgctc atgctggcgc agttgccaca gccaacaccg aatgaccgcc
     5881 gcaagctggg agtgctcatt cgtgcagaaa aagccgcaga gagggcgcta aaggctcgcg
     5941 ctgatgctgc taaagtgctg aacgccgaac gtcgcgccat tcgcaaagca cgtgaccacg
     6001 aactctacaa ggcggcaggt ctgatgggcg tggccggcgt ggttgaccgc caaaccgggc
     6061 ggctcaatgt ggatgccggc ctgcttgtcg gattgctcat ggagctgtcc gccggtacac
     6121 taccggacag cttgcaccgg gaaacgctta aatctcgcgg ggatgctgct atcgctgccc
     6181 gtgagaaaaa aaataaaacg aatcaggctg gctaatgaac ctcacacttg tttgccaata
     6241 gccctgagaa gccgcagaaa tcatcctgcg gctttttttt gcctttaggt agggaaacgt
     6301 acagggaaaa gaaaaaaacg ctcacagagc cttacagagc gttttagagc tatccgtcaa
     6361 ttcgttgctg gttccgggct gtgacgactg ccgcccctcc atcctgaaca gaccgggttt
     6421 taccttctcc gtcagtgaag cgatgccaga tcctgacggt cgaagacgta cagactttca
     6481 gcgatttgcc cgcccgtccg ggcgggtgct acctcctgcc ctagcgcgtt attcacaggg
     6541 atttacgggc attccgcatc ctgcagaaca ggcatattca taacctactg tttattttga
     6601 tgtttttttt tgcggcctcg ttttatccac agagccgccg ttaagttttt aagatctttt
     6661 ttttagatct tcttttttaa aacctttttc ggtcttgtaa ctttatgatt ttaaaagcgt
     6721 tctggcgaga taggtgagga aatcgggggt tataggtgag gaaatcgggg gttataggtg
     6781 aggaaatcgg gggttatagg tgaggaaatc gggggtacta tccacaaaaa aaggtgagta
     6841 aaaaaaaacg ttgctcacct tacactaagg tgataaaaca aaacacacac tcaccaaaag
     6901 aacataaatc actc
//
