LOCUS       NZ_AP026775            28491 bp    DNA     circular CON 27-NOV-2023
DEFINITION  Enterococcus faecium strain NUITM-VRE1 plasmid pNUITMVRE1_2,
            complete sequence.
ACCESSION   NZ_AP026775
VERSION     NZ_AP026775.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMD00533729
            Assembly: GCF_025998395.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1
  AUTHORS   Suzuki,M., Hashimoto,Y. and Tomita,H.
  TITLE     Complete genome sequence of Enterococcus faecium NUITM-VRE1
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 28491)
  AUTHORS   Suzuki,M., Hashimoto,Y. and Tomita,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2022) Contact:Masato Suzuki National Institute of
            Infectious Diseases, Antimicrobial Resistance Research Center; 4-2-1
            Aobacho, Higashimurayama, Tokyo 189-0002, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 2.1.1
            Genome Coverage                   :: 200x
            Sequencing Technology             :: Illumina HiSeq; ONT MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/27/2023 03:20:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,228
            CDSs (total)                      :: 3,138
            Genes (coding)                    :: 2,975
            CDSs (with protein)               :: 2,975
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 163
            CDSs (without protein)            :: 163
            Pseudo Genes (ambiguous residues) :: 0 of 163
            Pseudo Genes (frameshifted)       :: 65 of 163
            Pseudo Genes (incomplete)         :: 91 of 163
            Pseudo Genes (internal stop)      :: 36 of 163
            Pseudo Genes (multiple problems)  :: 25 of 163
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP026775.1.
            Annotated by DFAST https://dfast.ddbj.nig.ac.jp/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..28491
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="NUITM-VRE1"
                     /db_xref="taxon:1352"
                     /plasmid="pNUITMVRE1_2"
                     /geo_loc_name="Viet Nam:Hanoi"
                     /lat_lon="20.99138062 N 105.86277218 E"
                     /collection_date="2021"
     gene            complement(join(28489..28491,1..300))
                     /locus_tag="OO969_RS15640"
     CDS             complement(join(28489..28491,1..300))
                     /locus_tag="OO969_RS15640"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_264879951.1"
                     /translation="MRKTSVQKHVTLYPSHVDVLDSIIEKNPDINNYSEAIRFLCMSYE
                     PDTNTTTTSNQAKLNAMGKEISIMTEIIAEFADLYLKDTGVLIGTNSKVYQEVKE"
                     /name="hypothetical protein"
     gene            complement(303..587)
                     /locus_tag="OO969_RS15645"
                     /old_locus_tag="NUITMVRE1_30910"
     CDS             complement(303..587)
                     /locus_tag="OO969_RS15645"
                     /old_locus_tag="NUITMVRE1_30910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002337999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000353844.1"
                     /translation="MDILVRNIDPKFVATIDKRCQELTNKTGEKWSRNKYLKVLIESDF
                     DRQLTTYKKDQFDLLLDKFIAIQTENTQILSEYVYTNNQIIEMLIGGMI"
                     /name="hypothetical protein"
     gene            953..1177
                     /locus_tag="OO969_RS15650"
                     /old_locus_tag="NUITMVRE1_30920"
     CDS             953..1177
                     /locus_tag="OO969_RS15650"
                     /old_locus_tag="NUITMVRE1_30920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000410576.1"
                     /translation="MEKFPYEYFQNLEKLEQAIQAIKFDLTDEKLLEYKNMTPERKRSL
                     EKLMQLVNEDGGISDAAFDAWSEFHGEYN"
                     /name="hypothetical protein"
     gene            complement(2300..2980)
                     /locus_tag="OO969_RS15655"
                     /old_locus_tag="NUITMVRE1_30930"
     CDS             complement(2300..2980)
                     /locus_tag="OO969_RS15655"
                     /old_locus_tag="NUITMVRE1_30930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            <3056..3622
                     /locus_tag="OO969_RS15660"
                     /old_locus_tag="NUITMVRE1_30940"
                     /pseudo=""
     CDS             <3056..3622
                     /locus_tag="OO969_RS15660"
                     /old_locus_tag="NUITMVRE1_30940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002318326.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            complement(3669..3905)
                     /locus_tag="OO969_RS16205"
     CDS             complement(3669..3905)
                     /locus_tag="OO969_RS16205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002352178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_306297428.1"
                     /translation="MKQNTSIAKNTTKFKCTAAAWRISISPTNRTNNRGMILFIWISFF
                     LLGYRVLPAYFAPPKRRGRLERLVRNKNHSLSY"
                     /name="hypothetical protein"
     gene            4003..4182
                     /locus_tag="OO969_RS15670"
                     /old_locus_tag="NUITMVRE1_30950"
     CDS             4003..4182
                     /locus_tag="OO969_RS15670"
                     /old_locus_tag="NUITMVRE1_30950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002295613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001120991.1"
                     /translation="MPIAIGNKRLPVTLDEKRQKELQQLKQKYGKSESRIMCIALDLLI
                     AQEKAGFEVPALKK"
                     /name="hypothetical protein"
     gene            4313..4582
                     /locus_tag="OO969_RS15675"
                     /old_locus_tag="NUITMVRE1_30960"
     CDS             4313..4582
                     /locus_tag="OO969_RS15675"
                     /old_locus_tag="NUITMVRE1_30960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016632525.1"
                     /GO_component="GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
                     /protein_id="WP_000388479.1"
                     /translation="MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRD
                     YDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTHDLIEVESDD"
                     /name="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
     gene            4575..4832
                     /locus_tag="OO969_RS15680"
                     /old_locus_tag="NUITMVRE1_30970"
     CDS             4575..4832
                     /locus_tag="OO969_RS15680"
                     /old_locus_tag="NUITMVRE1_30970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016632526.1"
                     /GO_process="GO:0008219 - cell death [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Txe/YoeB family addiction module toxin"
                     /protein_id="WP_000588503.1"
                     /translation="MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGK
                     PEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYSAKDHY"
                     /name="Txe/YoeB family addiction module toxin"
     gene            5470..6078
                     /locus_tag="OO969_RS15685"
                     /old_locus_tag="NUITMVRE1_30980"
     CDS             5470..6078
                     /locus_tag="OO969_RS15685"
                     /old_locus_tag="NUITMVRE1_30980"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_224752223.1"
                     /translation="MIERLKDFMISVWDVAMLADESNYTSSIYRLEDSNWIEISLELKT
                     LPNSVNYIIRDITSEAQQLVNYMHGHESIPFSLILLKRSKNISNTRDRFISIITACEIG
                     VKEFYQQEKPDLTLIFENLQSPPVDKLLGSMFKGYFNIEFPKEIRKEIKNFIEKRNKLV
                     HSPQGSKPTIEECFECYMAVLKTFNFFYKINDSLNNSYF"
                     /name="hypothetical protein"
     gene            6212..7531
                     /locus_tag="OO969_RS15690"
                     /old_locus_tag="NUITMVRE1_30990"
     CDS             6212..7531
                     /locus_tag="OO969_RS15690"
                     /old_locus_tag="NUITMVRE1_30990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002338419.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1380-like element IS1678 family transposase"
                     /protein_id="WP_000202380.1"
                     /translation="MTSLHKNQVKFNSNITISHTGGQLSSDSGLVLVKELMNIFGFSEL
                     AKQHIHIEDERAYFTHDNLSILEQFIMQLIAGYSADSAANLLRQDPVFKAVLDRKELAS
                     QSSLSRFLDRLSEENIHELQALNQELIDKARLIRNDTELIIDLDSTHSDTFGHQEQTNY
                     NTHYQTYGYHPLVAFDGLTGDFLKAELRSGNQYTSKGVKEFLTPLLEHYNHSLPNTDIL
                     VRGDSGFATPGVYDSCESKKSHYVIRLKNNRRLGQIAEKSVLYGDNQKWEEREVQYFST
                     TYQAQSWSQSRRVCIRSTREAGELLFRHEFIVTNLSENVSPDTIFSIYAKRGTMENFIK
                     EAKAGFYFDKTDSPRFLENHVRMMLSLIAYNLVNFLRTIGFEEVQKGMTIHSIRLKFLK
                     VAGKLVQTGRRVYLKLSSYHVYQNEFYRVFARLRRASQWI"
                     /name="IS1380-like element IS1678 family transposase"
     gene            <7735..7977
                     /locus_tag="OO969_RS15695"
                     /old_locus_tag="NUITMVRE1_31000"
                     /pseudo=""
     CDS             <7735..7977
                     /locus_tag="OO969_RS15695"
                     /old_locus_tag="NUITMVRE1_31000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455809.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            complement(8142..8756)
                     /locus_tag="OO969_RS15700"
                     /old_locus_tag="NUITMVRE1_31010"
     CDS             complement(8142..8756)
                     /locus_tag="OO969_RS15700"
                     /old_locus_tag="NUITMVRE1_31010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001261742.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001261742.1"
                     /translation="MRVAYIRVSSIDQNEQRQIEEMKKFGAERIFIEKQSGATITHRPV
                     FQEALDYVRDQDIFIVEAIDRLGRNYDEIIASVNYLKKKNVKLIITSLPIMAEAIGNPL
                     LDKFIKDLIIQILAMIAEQERTESKRRQAQGIKIAKANGVYKGRPKLYSADAKDPQRRL
                     VYKSIVEDLKNGVAIAKIAKDYNVTRQTVYRIKKDSMVNDK"
                     /name="recombinase family protein"
     gene            9206..10531
                     /locus_tag="OO969_RS15705"
                     /old_locus_tag="NUITMVRE1_31020"
     CDS             9206..10531
                     /locus_tag="OO969_RS15705"
                     /old_locus_tag="NUITMVRE1_31020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="WP_000969590.1"
                     /translation="MMDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRAD
                     NTGSGLILASSPEAKKRYGITNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTRSLNLFTTEGTRSQRRKKLAQMIQENIKEELGLIATVG
                     VGDNPLLAKLALDNEAKHNEGFVAEWTYENVPEKVWNIPEMTDFWGIGSRMKKRLNQMG
                     IMSIRDLANWNPYTIKNRLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLHIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSDPQKQIDEENLDKIIDK
                     IRQKYGFTSIVHASSMLEGARSITRSTLVGGHAGGNGGIKND"
                     /name="Y-family DNA polymerase"
     gene            10524..10874
                     /locus_tag="OO969_RS15710"
                     /old_locus_tag="NUITMVRE1_31030"
     CDS             10524..10874
                     /locus_tag="OO969_RS15710"
                     /old_locus_tag="NUITMVRE1_31030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000568378.1"
                     /translation="MIDYNDRGRLKWAGFYLSDHTEEIDADNEQRTSQNLAKEQMTTEE
                     IAEVLNAAVIKNRSVSIQKEERNAEGYYPEDIIGKILGSDELGIYVGKDKIHYDEIRHI
                     EFYQDNKWSRLE"
                     /name="hypothetical protein"
     gene            10871..11050
                     /locus_tag="OO969_RS15715"
                     /old_locus_tag="NUITMVRE1_31040"
     CDS             10871..11050
                     /locus_tag="OO969_RS15715"
                     /old_locus_tag="NUITMVRE1_31040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001021554.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEAAA
                     GYHNFRFYIFPLYI"
                     /name="hypothetical protein"
     gene            11186..11476
                     /locus_tag="OO969_RS15720"
                     /old_locus_tag="NUITMVRE1_31050"
     CDS             11186..11476
                     /locus_tag="OO969_RS15720"
                     /old_locus_tag="NUITMVRE1_31050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000026576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000026576.1"
                     /translation="MSINTFVYSHPINVYIIKNLGITVEQFCELYAYPQGTVASWITRQ
                     RRIKSLPASFVYDLSLASSLNMSDVYEKLLSLEKEYDSFKIKHDKKIKKHI"
                     /name="hypothetical protein"
     gene            11844..12632
                     /locus_tag="OO969_RS15725"
                     /old_locus_tag="NUITMVRE1_31060"
     CDS             11844..12632
                     /locus_tag="OO969_RS15725"
                     /old_locus_tag="NUITMVRE1_31060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002302898.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA]"
                     /GO_process="GO:0007059 - chromosome segregation [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WP_000101106.1"
                     /translation="MARILSVANQKGGVSKTTTSVNLAACLKFVYGKNVLLVDIDPQGN
                     ATDNVGFDIDGTNQPTIYEVLKGEADITDAILDYKGIDVLPADIALSSAEREFTQVGSE
                     HRLKRVLQPIKDNYDYIIIDCPPSLGMLTVNAFTVSDEIIIPVEAAYFSLKGLIKLSET
                     IETVKEYTNDKLEVRGVLFTKYNKRYNISKEMTSAATEISRVIGAKIFKTYIRRTITVD
                     EAQAAGSDLINFNKPSTAEDDYKAFTEEYLKEVGDFDGRR"
                     /name="AAA family ATPase"
     gene            12619..12945
                     /locus_tag="OO969_RS15730"
                     /old_locus_tag="NUITMVRE1_31070"
     CDS             12619..12945
                     /locus_tag="OO969_RS15730"
                     /old_locus_tag="NUITMVRE1_31070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002299230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000796719.1"
                     /translation="MAEDNRSQAAVSRLLGNKNKKNFKSKEVEEIELTKKNISKVIKDQ
                     GSSVRTADSIRINPILMSALKYWTTIAESDKSKPDVIEDALLKSIPEEYLIEGYKLAKK
                     QNKI"
                     /name="hypothetical protein"
     gene            13294..14334
                     /locus_tag="OO969_RS15735"
                     /old_locus_tag="NUITMVRE1_31080"
     CDS             13294..14334
                     /locus_tag="OO969_RS15735"
                     /old_locus_tag="NUITMVRE1_31080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002343466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_000997689.1"
                     /translation="MNDFNYYKSKEIYREKYYQMPKVFFTNEKYMDLSNDAKIAYMLLK
                     DRFDYSVKNNWVDSDDNIFFIFTVEELMKLLQCREGKVSKIKKELEKAGLLKQKRGRVN
                     KRDGKIESMPNLLYLGKPEVTNQDVFKIMEEEDNTDTTVIAKIANTAKPREINDTTVIA
                     KIANTAKSSHIKDSTVIAKIADNLFYSNSIDTNRHIIDTETDQLQNQVLLDNFVDIMKE
                     DSINTFVPENVLNLIKTFSSTYEDAQKTVQTIHNAKKKAEELEQTVVVYEELESYGIDA
                     DKGLYMTLLKAYQKQKTEKVNNLQNLIFVYVKNWFVEKAIAAKLANEQRETFNELPTVS
                     TENWLE"
                     /name="replication initiator protein A"
     gene            complement(14950..15630)
                     /locus_tag="OO969_RS15740"
                     /old_locus_tag="NUITMVRE1_31090"
     CDS             complement(14950..15630)
                     /locus_tag="OO969_RS15740"
                     /old_locus_tag="NUITMVRE1_31090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            <15705..16088
                     /locus_tag="OO969_RS15745"
                     /old_locus_tag="NUITMVRE1_31100"
                     /pseudo=""
     CDS             <15705..16088
                     /locus_tag="OO969_RS15745"
                     /old_locus_tag="NUITMVRE1_31100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001226076.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /name="recombinase family protein"
     gene            16302..16997
                     /gene="vanR-A"
                     /locus_tag="OO969_RS15750"
                     /old_locus_tag="NUITMVRE1_31110"
     ARG             16303..16994
                     /name="vanR-A"
                     /gene="vanR-A"
                     /gene_name="vancomycin resistance response regulator
                     transcription factor VanR-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="99.57"
                     /coverage="100.0"
     gene            16975..18129
                     /locus_tag="OO969_RS15755"
                     /old_locus_tag="NUITMVRE1_31120"
     CDS             16975..18129
                     /locus_tag="OO969_RS15755"
                     /old_locus_tag="NUITMVRE1_31120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002305818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="vancomycin resistance histidine kinase VanS-A"
                     /protein_id="WP_002305818.1"
                     /translation="MVIKLKNKKNDYSKLERKLYMYIVAIVVVAIVFVLYIRSMIRGKL
                     GDWILSILENKYDLNHLDAMKLYQYSIRNNIDIFIYVAIVISILILCRVMLSKFAKYFD
                     EINTGIDVLIQNEDKQIELSAEMDVMEQKLNTLKRTLEKREQDAKLAEQRKNDVVMYLA
                     HDIKTPLTSIIGYLSLLDEAPDMPVDQKAKYVHITLDKAYRLEQLIDEFFEITRYNLQT
                     ITLTKTHIDLYYMLVQMTDEFYPQLSAHGKQAVIHAPEDLTVSGDPDKLARVFNNILKN
                     AAAYSEDNSIIDITAGLSGDVVSIEFKNTGSIPKDKLAAIFEKFYRLDNARSSDTGGAG
                     LGLAIAKEIIVQHGGQIYAESNDNYTTFRVELPAMPDLVDKRRS"
                     /name="vancomycin resistance histidine kinase VanS-A"
     gene            complement(18227..19519)
                     /locus_tag="OO969_RS15760"
                     /old_locus_tag="NUITMVRE1_31130"
     CDS             complement(18227..19519)
                     /locus_tag="OO969_RS15760"
                     /old_locus_tag="NUITMVRE1_31130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016628567.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3-like element IS1251 family transposase"
                     /protein_id="WP_000122610.1"
                     /translation="MSYTHLIKETLDILDLSVTFNENCLTKEKYKGQICHIYRGNLIYT
                     AQECIHCKHQIASDIVRWGTTTVRLLMNDVSEYRTYLELKKQRFKCKACQRTFVADTSV
                     AKKHCFISEKVRWSVVTRLKKNTSMTEIAAQKNLSVSSVYRIMKRFYRPLNPFRTPLPK
                     VLCFDEFKSVRGVSGAMSFIMMDGQTQRLLDIVENRQLPFLKRYFSHFSREIREAVEWI
                     VIDMYAPYVSLVKKLFPKAQLIIDRFHIVQHIGRTFRNHRIKETNQLLKSKEQKHYQLG
                     KQLKRYWKLLQKDERKLDYTRRLWRPGFKAHLTETDIVDRLLKGSPALRVGYQLYQDFL
                     YAVKERDYVSFEELLTNNIMLPEGYQTTLRTFQKFLPQIKNALQQSYSNGPLECLNNHI
                     KVLKRNAYGFRSFYNFKLRIMIRHGNALIFN"
                     /name="ISL3-like element IS1251 family transposase"
     gene            19851..20819
                     /locus_tag="OO969_RS15765"
                     /old_locus_tag="NUITMVRE1_31140"
     CDS             19851..20819
                     /locus_tag="OO969_RS15765"
                     /old_locus_tag="NUITMVRE1_31140"
                     /EC_number="1.1.1.28"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001059542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-lactate dehydrogenase VanH-A"
                     /protein_id="WP_001059542.1"
                     /translation="MNNIGITVYGCEQDEADAFHALSPRFGVMATIINANVSESNAKSA
                     PFNQCISVGHKSEISASILLALKRAGVKYISTRSIGCNHIDTTAAKRMGITVDNVAYSP
                     DSVADYTMMLILMAVRNVKSIVRSVEKHDFRLDSDRGKVLSDMTVGVVGTGQIGKAVIE
                     RLRGFGCKVLAYSRSRSIEVNYVPFDELLQNSDIVTLHVPLNTDTHYIISHEQIQRMKQ
                     GAFLINTGRGPLVDTYELVKALENGKLGGAALDVLEGEEEFFYSDCTQKPIDNQFLLKL
                     QRMPNVIITPHTAYYTEQALRDTVEKTIKNCLDFERRQEHE"
                     /name="D-lactate dehydrogenase VanH-A"
     gene            20812..21843
                     /gene="vanA"
                     /locus_tag="OO969_RS15770"
                     /old_locus_tag="NUITMVRE1_31150"
     ARG             20813..21840
                     /name="vanA"
                     /gene="vanA"
                     /gene_name="D-alanine--(R)-lactate ligase VanA"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="99.71"
                     /coverage="100.0"
     gene            21849..22457
                     /locus_tag="OO969_RS15775"
                     /old_locus_tag="NUITMVRE1_31160"
     CDS             21849..22457
                     /locus_tag="OO969_RS15775"
                     /old_locus_tag="NUITMVRE1_31160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-Ala-D-Ala dipeptidase VanX-A"
                     /protein_id="WP_000402348.1"
                     /translation="MEIGFTFLDEIVHGVRWDAKYATWDNFTGKPVDGYEVNRIVGTYE
                     LAESLLKAKELAATQGYGLLLWDGYRPNRAVNCFMQWAAQPENNLTKESYYPNIDRTEM
                     ISKGYVASKSSHSRGSAIDLTLYRLDTGELVPMGSRFDFMDERSHHAANGISCNEAQNR
                     RRLRSIMENSGFEAYSLEWWHYVLRDEPYPNSYFDFPVK"
                     /name="D-Ala-D-Ala dipeptidase VanX-A"
     gene            22885..23796
                     /gene="vanY"
                     /locus_tag="OO969_RS15780"
                     /old_locus_tag="NUITMVRE1_31170"
     CDS             22885..23796
                     /gene="vanY"
                     /locus_tag="OO969_RS15780"
                     /old_locus_tag="NUITMVRE1_31170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanY-A/VanY-F/VanY-M family D-Ala-D-Ala
                     carboxypeptidase"
                     /protein_id="WP_000732308.1"
                     /translation="MKKLFFLLLLLFLIYLGYDYVNEALFSQEKVEFQNYDQNPKEHLE
                     NSGTSENTQEKTITEEQVYQGNLLLINSKYPVRQESVKSDIVNLSKHDELINGYGLLDS
                     NIYMSKEIAQKFSEMVNDAVKGGVSHFIINSGYRDFDEQSVLYQEMGAEYALPAGYSEH
                     NSGLSLDVGSSLTKMERAPEGKWIEENAWKYGFILRYPEDKTELTGIQYELWHIRYVGL
                     PHSAIMKEKNFVLEEYMDYLKEEKTISVSVNGEKYEIFYYPVTKNTTIHVPTNLRYEIS
                     GNNIDGVIVTVFPGSTHTNSRR"
                     /name="vanY"
     gene            23949..24434
                     /gene="vanZ-A"
                     /locus_tag="OO969_RS15785"
                     /old_locus_tag="NUITMVRE1_31180"
     ARG             23950..24431
                     /name="vanZ-A"
                     /gene="vanZ-A"
                     /gene_name="glycopeptide resistance protein VanZ-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(24721..25050)
                     /locus_tag="OO969_RS15790"
                     /old_locus_tag="NUITMVRE1_31190"
     CDS             complement(24721..25050)
                     /locus_tag="OO969_RS15790"
                     /old_locus_tag="NUITMVRE1_31190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000754864.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000754864.1"
                     /translation="MKKVCQVTVVHKEKVNGIKNKLDQKDFSNLLVLGKCFSDFSRIKI
                     FYALETYKEMCVCDLAEILTASVATTSHHLRFLKKHGMAKSRQDGKVVYYSLANEDILS
                     AIRVF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            25355..25684
                     /locus_tag="OO969_RS15795"
                     /old_locus_tag="NUITMVRE1_31200"
     CDS             25355..25684
                     /locus_tag="OO969_RS15795"
                     /old_locus_tag="NUITMVRE1_31200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005877489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000629052.1"
                     /translation="MITKTRKQGNSIMLTVPKEFDVPNGVEVEAKLVENGILYEFVEPK
                     KEFFDFSEDILADILSEGYSKQEILKEFRNRKNALTSAFKSIAEDTVANSKPMTKEELA
                     AEIGL"
                     /name="hypothetical protein"
     gene            25674..25961
                     /locus_tag="OO969_RS15800"
                     /old_locus_tag="NUITMVRE1_31210"
     CDS             25674..25961
                     /locus_tag="OO969_RS15800"
                     /old_locus_tag="NUITMVRE1_31210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000312842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_000312842.1"
                     /translation="MAYEILPSKHVIKYLKKLKEKTLKEQFLTIIYDEIAVRPHSGEQK
                     TGDLSGIWAIGFKYAGTTYRVAYEIKDNAVIPNLLCGTHENFYEQLKKIR"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(26240..26766)
                     /locus_tag="OO969_RS15805"
                     /pseudo=""
     CDS             complement(26240..26766)
                     /locus_tag="OO969_RS15805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017550078.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /name="recombinase family protein"
     gene            complement(26791..27471)
                     /locus_tag="OO969_RS15810"
                     /old_locus_tag="NUITMVRE1_31240"
     CDS             complement(26791..27471)
                     /locus_tag="OO969_RS15810"
                     /old_locus_tag="NUITMVRE1_31240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            27577..28254
                     /locus_tag="OO969_RS15815"
                     /old_locus_tag="NUITMVRE1_31250"
     CDS             27577..28254
                     /locus_tag="OO969_RS15815"
                     /old_locus_tag="NUITMVRE1_31250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002353733.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_047211305.1"
                     /translation="MNLVPLKNFNAKQMDLFFALCARMKDRGLKKVRFSFEELKELSDY
                     KMTATKAFVGDLEKLYKDMLNLTYRTEDEDSIRYFVLFTGFEINKTKKFVEVSVNPDLE
                     YIINGLTAEFSRFELSAFTSLRSTYAKTLFRLLMQYRSTGYYVVRIEEFRSLMDIPEYY
                     QMGNIDQKVLNPALRELKKYFNDLKVTKIKAKKGNKIAKLEFTFSSLTSDLPKISLRNW
                     LEE"
                     /name="replication initiation protein"
     ARG             19852..20816
                     /name="vanH-A"
                     /gene="vanH-A"
                     /gene_name="D-lactate dehydrogenase VanH-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             16976..18126
                     /name="vanS-A"
                     /gene="vanS-A"
                     /gene_name="vancomycin resistance histidine kinase VanS-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             22886..23793
                     /name="vanY-A"
                     /gene="vanY-A"
                     /gene_name="D-Ala-D-Ala carboxypeptidase VanY-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="99.67"
                     /coverage="100.0"
     ARG             21850..22454
                     /name="vanX-A"
                     /gene="vanX-A"
                     /gene_name="D-Ala-D-Ala dipeptidase VanX-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             19852..20819
                     /name="vanH gene in vanA cluster"
                     /gene="vanH gene in vanA cluster"
                     /gene_name="vanH; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             16303..16997
                     /name="vanR gene in vanA cluster"
                     /gene="vanR gene in vanA cluster"
                     /gene_name="glycopeptide resistance gene cluster; vanR"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.57"
                     /coverage="100.0"
     ARG             22886..23796
                     /name="vanY gene in vanA cluster"
                     /gene="vanY gene in vanA cluster"
                     /gene_name="vanY; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.67"
                     /coverage="100.0"
     ARG             23950..24434
                     /name="vanZ gene in vanA cluster"
                     /gene="vanZ gene in vanA cluster"
                     /gene_name="vanZ; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             16976..18130
                     /name="vanS gene in vanA cluster"
                     /gene="vanS gene in vanA cluster"
                     /gene_name="vanS; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="94.79"
     ARG             21850..22457
                     /name="vanX gene in vanA cluster"
                     /gene="vanX gene in vanA cluster"
                     /gene_name="vanX; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.5"
                     /coverage="100.0"
     Typing          13295..14334
                     /name="rep_cluster_889"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          27547..28254
                     /name="rep_cluster_1763"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="98.0"
                     /evalue="0.0"
ORIGIN
        1 ttctttcact tcttgatata ctttagaatt tgtgccaata agaacgcctg tatcttttag
       61 atataaatca gcaaattctg cgatgatttc agtcatgatg gaaatttctt ttcccatagc
      121 atttagtttt gcctgattgc tggtagtggt cgtgttggta tcgggttcat aactcataca
      181 taaaaagcga atggcttccg agtagttatt gatatctgga tttttttcga tgatggaatc
      241 taaaacgtca acatgactag ggtacaaagt aacatgtttt tggacagaag tttttctcat
      301 ggttatatca ttcctccgat aagcatttca atgatttgat tatttgtgta gacatactcg
      361 cttaatattt gagtattttc tgtttggata gcaataaatt tatcgagcaa taaatcgaat
      421 tggtcttttt tgtaagtcgt aagttgacgg tcaaaatcac tttcgattaa aacttttaga
      481 tatttatttc gactccattt ttctcctgtt ttattcgtga gttcttggca acgtttgtct
      541 attgttgcaa caaactttgg atcaatattc cgaactaaaa tgtccataaa aaatctcctt
      601 ttgcaattat gtataattta tgtataccat acaaatacta tatttgtata gctgtttttt
      661 gccaaaatgc tatacataag ctacccacga tggcgaaaaa gtgatatcaa atttttttct
      721 gagaaacgtg ataggcacag cctatctacc cacttttttt agaaagtggg tacacgtttc
      781 cttatgctct ttaaaattcg ggggggagtg ctgcacgtgt aatcgataac caaatttaaa
      841 aatgcacgat caaaaattta tttagttttt caaacgacat tttttttgag agtatagacg
      901 gcaaagaagt gattttattt ctagaaaaat tgtgagactg gagaaagaaa aaatggaaaa
      961 atttccttac gaatattttc aaaacttaga aaaattagag caagcaattc aagcaatcaa
     1021 gttcgattta acagacgaaa aattgttgga atataaaaat atgacacccg aaagaaaacg
     1081 atcgttggaa aaattaatgc aactagtgaa cgaagacggc ggaatttcag acgcagcttt
     1141 tgacgcatgg agcgaatttc atggagaata taattaagtg ggtttaaatg gctctaaaat
     1201 cgcttctaag agttttttag cttggaccaa tgaaatacac caaaaactaa ataaaacgtc
     1261 ttaaatcgaa aaatacgagc tctcagagcg actttatttg taaatgttgc atataagaaa
     1321 taattacgga ttttagactt ttgtaggata tttttgaaat aaatatttat ttctgttata
     1381 atttgattgc aaataagtga acacgaaaca cacgaaagcc ccagagaggt cggattctct
     1441 ggggcttttt ttgtgggctg agtcgcctta attaagtttt acttcttgtt tcggttattc
     1501 aaccagtaac tgaacaaagc gcttaaaagc ccaacaagaa gggagcaaat aaagttagtg
     1561 aacacgaaac acacctcctt ccagtcgcaa gactgtcgga taggcgacaa tcaattatac
     1621 aataaaaaag caaaaataag cctaagtttt ttattgcctt ggggttgtta gggcttgccc
     1681 tgaccgcctg taaggcgctt tagaacgaag gacatagttt ttatcgaatc ttgtcttaga
     1741 acggcttaga cgagctctca ggacgccaca aaggagtccc taatgaatta tttttggcga
     1801 aggagcctaa aggcgactgc tgcaagtaaa atgtgagagc gtagcgatca ctccttctta
     1861 cagcgaccat agggagctag attggcagtt taatatcatg cgcgaacctg tttattttaa
     1921 aaagtgggtg attttttggc gggaaatttt gctcgcgcgc gcgcgtttat tttatttatt
     1981 ttttaaagat tttttagaac cctttttagg gggcagttga gccttactct cccaacggat
     2041 acagaagggt actaacaact ttttatctga gtactaacaa ctttttatct gagtactaac
     2101 aactttttat ctgagtacta acaacttttt atctgagtac taatatcctt ttgtataata
     2161 acaaccaacc tatttacgag ttggttgtta aaggttatta tttatttgta aggggggaag
     2221 aaaggaatgg atgaaaaaac ggaatggttc tgttgcaaag ttttaaataa agaataaaat
     2281 cccttacggt atctatgatt taagctggga ttcccaataa taccttgatt tcagtacaga
     2341 ccgaaaaccc gaagagagtg ccttcttttc gggttttctt atataatcct cgaatggctt
     2401 ccatgccttt aatcgtggta gaggcagtgc gtaaacttcg atagaattta ttgcgtctct
     2461 ttactggacg atggtcttgt tcaatcaaat tattcaggta tttaatggta cgatgttctg
     2521 tcccttgata aaagccgtat tcttttagtt tcttaaaggc acttgtaata gagggggctt
     2581 tatctgtgac tacaaccttc ggttcatcaa actgcttcac taaccgctta agaaaagcat
     2641 aggctgcttg tgtgtcccgt tttttacgta accaaatatc caaggttaaa ccatctgcat
     2701 cgatggctcg atacaaataa tgccattttc ctttaatttt gatgtacgtt tcatccattt
     2761 tccatgaata aaaggatttt ttatttttct ttttccaaat ttgatagagt agtttgccat
     2821 attcttgcac ccaacgataa atcgtcgtat gagaaacgtt aatgccacga tcatataaga
     2881 tttcttgaac ttcacgatag ctaaggttat aacgaagata gtagcccacg gctacaataa
     2941 tcacatcctg ctgaaattgc tttcctttaa aatgattcat cgtcattcct cctgctatct
     3001 ttttctatta ttctacctta tttgatagta gatttaaaac tttgcaacag aacccgaaga
     3061 acaattgtat ttggaaagtg aaacgagtca aacgaaggtc acagtcagcc ataatcgttt
     3121 agacgtgtat aaacgtcgtc ctgaaacggt aaaaaaagga acggagcttc tacgactaga
     3181 aacagaaaaa tacatcatga atgtttacct agaaaggagt gagctggtcg aaaactttgt
     3241 cagctacacg atttgcagga aacactatta ctcagaatca gaatattatt caatttttga
     3301 gagcatggaa ttaatggaag aagaaatgga agagctaaac agcaaagatg cgacgataga
     3361 cgattattac cttgtattta ctagattttt gacgtgtgga acggaatcta tcgtgttaat
     3421 gggaatggat tatgaactcg ctgtacccga agcatttttg agggaatatg tagaagaagt
     3481 agataaccca ggcgacgact ggtacacgac tttaactgat tttttagaca cctatactta
     3541 cgacgataca gaagaaatcc aaaatgaact tgaccgtaaa cgaatgccat atcaacgatt
     3601 tgaaaggaaa aaaaggcaat aatcatttat accgaaaagt gagaatgtgt gaaataagga
     3661 caaaaaacct agtaactaag ggaatggttc ttatttcgca ccaatcgctc caaccgcccc
     3721 cgccgcttag gtggtgcgaa ataagcgggc aacacccgat aacctaagag aaagaaggag
     3781 atccatatga ataaaatcat tcctctattg ttagtcctat ttgttggcga aatacttatg
     3841 cgccatgctg cagctgtgca tttaaacttc gtagtatttt tggcaatact ggtattttgt
     3901 ttgatctttt ggcgctttgt attagccctt gtgagtctac tattcaagat gattgcagcc
     3961 atatttttca tagggttatt tcgatgaaag gagagagtac taatgccaat tgcaatagga
     4021 aataaacggt tacccgttac gttggatgaa aagagacaaa aagaattgca gcaactaaag
     4081 cagaagtacg gcaaaagtga atccaggatt atgtgtattg cgttagattt attgattgcc
     4141 caagaaaaag caggatttga ggtaccagca ctcaaaaagt gacgtcactt tttatcctaa
     4201 aaactaaaag tgatagcact tttaattata agaagttaga atattaatca tttgcttaat
     4261 tgtacaatat aatgtacaat tgttttatag aaataaataa ggggtgaaag gaatggaagc
     4321 agtagcttat tcaaatttcc gccaaaattt acgtagttat atgaaacaag ttaatgagga
     4381 tgctgaaaca cttattgtaa caagtaaaga tgtagaagat acagttgttg tattatcaaa
     4441 aagagattat gattctatgc aagaaacgtt gagaacactt tctaataatt acgtcatgga
     4501 aaaaattcgt cgaggagatg aacaattctc caaaggtgca tttaaaacac atgacttaat
     4561 cgaggttgaa tctgatgatt aaggcttggt ctgatgatgc ttgggatgat tatctttatt
     4621 ggcatgagca aggaaacaaa agcaatataa aaaagattaa caagttaata aaagatatcg
     4681 atcgttcccc ctttgctgga ttaggaaaac ctgagccatt aaagcatgat ttatctggaa
     4741 aatggtccag aagaattaca gatgaacata gactgatata tagagttgaa aatgaaacga
     4801 tatttattta ttctgcaaaa gatcactatt aaccaatcgg aagtaaggaa agggtcagaa
     4861 acttaaaagt ttttgatcct tattttattt accctagtca tttaaaaagc taatatagct
     4921 tagtgttgat tgttattaat gaatgtgttt gttacgcgta ttacggatat aaggttagta
     4981 aaatcatttc taaagttgag gaaaagtaaa tataaatggc ttaaatttca acaatttgaa
     5041 gttgaataga tatgttataa tactattgta gtgtgggatg ttagttacta aaggatgacg
     5101 cttatatata tgactgaata gaataagcaa taggtttaat aatctatttt aaattttttg
     5161 tactagtttt agttaattag caaaaacaac aaaaataaac ttctcataga atttagctaa
     5221 aaattaatga tttatttaca tattaaattt ggatacagtt aagtaatttt tatatattgg
     5281 aggagaagta atggaatata aatttaactt gaatttgaaa gaagtactcc ccactcaggg
     5341 aacaataaac ataaatggtc aagataatga tgacgatata gtaataaaaa aatagaattt
     5401 attgattctg atataaatgt ttttttttat tctaaagaaa aattagctga ttttagcaat
     5461 attgctgaaa tgattgaacg tttaaaagat tttatgatca gtgtttggga tgtagcgatg
     5521 cttgctgacg aatcaaatta tacttcgagc atatacagat tagaagatag taattggata
     5581 gaaatttcat tagagttaaa gacacttcct aattccgtta actatataat tagagatata
     5641 acttctgaag ctcaacaatt agttaattac atgcatggac acgaaagtat ccccttttct
     5701 cttatactcc ttaaaagaag taaaaatata tcaaatacta gagataggtt tatttcgata
     5761 attacagcct gtgaaatagg ggtaaaggaa ttttatcaac aagagaaacc tgatttaact
     5821 ctaatatttg agaatttaca atctccccct gtagacaaat tattagggag catgtttaaa
     5881 gggtacttta atattgagtt tccgaaagaa ataagaaagg aaattaaaaa tttcatagaa
     5941 aaacgtaata aattggttca ttctcctcaa ggaagtaaac caactataga agaatgtttt
     6001 gaatgttata tggcagtgct aaaaacattt aatttttttt ataaaattaa tgatagcctg
     6061 aataattcat acttttaatt aaaaccatgt gaaactgcct cacggcagct tacaattact
     6121 ttttcatctt cacccgttaa gtgatgaaaa aagaacccct ttctgctatg gttaaagtga
     6181 ctaaaccaac caaaagaaag gagttctttt catgactagc ttacacaaaa accaagtaaa
     6241 attcaattca aatatcacta tttctcatac aggtggtcaa ttatcgagtg attcgggtct
     6301 cgtcctagtg aaagagctga tgaacatctt tggtttttct gaactggcta agcaacacat
     6361 tcacattgaa gacgaacgag cgtattttac tcatgacaac ttatccatac ttgagcagtt
     6421 cattatgcaa ttaattgctg gttactcagc tgattctgca gctaatctcc tgagacaaga
     6481 tcctgtgttt aaagctgttt tagataggaa agaactcgct tctcaatctt cactttcccg
     6541 atttttagat cgactatctg aggagaatat ccatgaactt caagctttga accaagaact
     6601 tatcgataaa gcacgcctca tccgtaatga tacggaatta atcattgatt tagattcgac
     6661 ccattcagat acatttggtc accaagaaca aacgaattat aatacacact accaaaccta
     6721 tggttaccat ccattggtag cttttgacgg attgactggt gacttcttaa aagctgaact
     6781 acgttcagga aatcaatata catcaaaagg cgtaaaggag tttctcacac ctttattaga
     6841 gcactataat cactctctac caaacactga catcttggtt cgtggagaca gcgggttcgc
     6901 tacacctggt gtgtatgatt cgtgtgaatc aaaaaagagt cattatgtta ttcgactgaa
     6961 gaataatcgt agactaggtc aaatagctga gaaatcagta ctttatggcg ataatcaaaa
     7021 gtgggaagaa cgagaagttc agtacttctc gaccacttat caagcacaat cctggtcaca
     7081 aagtcgtcgc gtgtgtatac gctcaacacg tgaagcgggc gaactactct ttcgacatga
     7141 atttatcgtg acgaatctat cagaaaatgt ttctcctgat accatctttt ctatctatgc
     7201 caaacgtggc acaatggaga acttcattaa agaagcgaaa gctggctttt actttgacaa
     7261 aacagacagt cctcgctttt tggagaatca tgtccgaatg atgctcagct tgatagctta
     7321 caacttagtc aacttcttaa gaacgattgg ctttgaagaa gtccaaaagg gaatgaccat
     7381 tcattctatt cgattgaagt ttctgaaagt tgctgggaaa ttagtccaaa cgggtagacg
     7441 agtctatctc aaattatcta gttatcatgt gtatcagaat gaattctaca gggtctttgc
     7501 tcgcctgagg cgagccagtc aatggatcta atccaacaat ctaacgattt ttttactggg
     7561 aagttatcca gggagaagta tgctcaaaat gccttacacc caaaatttat tcctcaatat
     7621 ttttgaacag tgaatgtttg aagtaacttt ttagtcaaaa tcagttgata gggatattag
     7681 tgatacatat ttcaataaaa tgtgccaaag aattaaagct atgaattatt cagggatagc
     7741 tttatgtata gagattttta tgaagaatct atagaattga ctccaacgga accaaataaa
     7801 tctcaaatca ctttgtcaaa ggagctagag agaaaagtag agtctcaaga actagctata
     7861 ggaattagta taaccaatgt gtcgacatac aaagaattat acgaagctaa atcacaagat
     7921 aataaggatt ttgtagaaaa tatagataag gaaccaacaa atacagtagg ggattaacgt
     7981 aaataagtga agattatatt aacagactct ttatttagtt aagtaaaaaa tggtttgttg
     8041 gaattttatg ctttatctgt tctgagtaag acttaatttt atagatagta attatatgta
     8101 ggaaattaaa gatgagaaga taataaaagc agcatgatca actatttgtc attgaccatg
     8161 ctgtcttttt ttattctata cacggtttgt ctcgtaacat tgtagtcttt agcaatctta
     8221 gcaatcgcaa caccattttt aagatcttca acgatgcttt tgtaaacaag gcgacgttgg
     8281 ggatcttttg cgtctgcact gtataatttg ggccgccctt tgtagacgcc gtttgctttt
     8341 gcgatcttaa ttccttgtgc ctggcgacgt ttcgattcag tccgttcttg ttcagcgatc
     8401 atggccaaaa tttggatgat cagatcctta atgaatttat ccaggagagg attgccaatt
     8461 gcttcagcca tgatcggtaa actagtaatg atcagcttca catttttctt cttcaagtaa
     8521 ttgactgaag cgatgatctc gtcataattt cttccaagtc gatcaatagc ttccacaata
     8581 aaaatatctt gatctcggac gtaatctaat gcttcttgga aaacaggtcg atgagtaatc
     8641 gttgcgccag attgtttctc gatgaaaatt ctctctgcac cgaatttttt catttcttca
     8701 atctggcgtt gttcattttg atcgatcgat gagacacgta tgtatgcaac tctcaaaact
     8761 tttacctact ttctgcaact atttaaaata caccctaatc atacacgagg aagccatatt
     8821 tttcaatgtt ataccagtgt ctatttaggg tataccttat atagacaaaa actaatgatg
     8881 gaggaaatag tatgagaatt ttttgtaagt gtctactgat aacttattct caaatgttgt
     8941 aaggatttta ttcatttgtt aatattaaag aacggaactc caaaaaagtc cgtactctaa
     9001 tttgcagtct ctcactcttt tagagtgaga gtttttatta gattttcaaa ttaattagta
     9061 aagtgataga ataaattgat catacaaatc aaaagaagaa gcagggtgat agcataccta
     9121 tgcttctttt tttatgtatt tagctatttc ttctttacaa tatcgaacat atgtttgtat
     9181 aatgtgaaag aatggagtgt tatttatgat ggattattca aaagagccag taaatgatta
     9241 ctttttaatc gatatgaaaa gcttttacgc aagtgtcgaa tgtatagaaa gaaatttaga
     9301 tccattaaca acagaacttg ttgttatgag tcgagctgat aatactggtt caggattgat
     9361 attagcttct tctcctgaag caaaaaagcg gtatggtatt acaaatgtga gtagaccacg
     9421 tgacttacca caaccatttc ctaaaacact acacgttgtt ccaccacgta tgaacctata
     9481 tatcaagcga aatatgcagg taaataatat tttcagaaga tatgtggctg atgaagatct
     9541 actgatttac tcgatcgatg aatcaatctt aaaagtgacc cgatcactga atctttttac
     9601 gactgaagga acacgaagtc aacggagaaa gaagctggct caaatgatcc aggagaatat
     9661 taaagaagag ctaggattga ttgctacagt aggtgtcgga gataatcccc ttttggctaa
     9721 actagcctta gacaacgaag caaagcataa tgaaggattt gttgcggaat ggacgtacga
     9781 aaacgttcct gaaaaagtat ggaatattcc tgaaatgacg gacttttggg gaattggctc
     9841 tcgaatgaaa aaaagactca atcagatggg gattatgagc attagagatc ttgctaactg
     9901 gaatccttat acgattaaga atagactagg tgtgattggc ttacagctgt acttccatgc
     9961 taatgggatc gatcgaacag atatagcaat cccaccagaa ccgacaaagg aaaaatcata
    10021 tggaaattca caagtgttac cacgagatta tactagaaga aatgaaatcg agctggtggt
    10081 aaaagaaatg gcggaacaag tagcgatacg cattaggcag cataactgta aaacaggttg
    10141 tgtccattta cacattggca cgtcgatctt agaaacgaga ccagggtttt cacaccagat
    10201 gaagatccct atcacagata atacaaagga attgcagaat tattgtcttt tcttgtttga
    10261 taagtattat gaaggacaag aagtaaggca tgttggaata acctatagca agcttgtgta
    10321 caccgattcg cttcagctgg atttatttag tgatccacaa aagcaaattg acgaagaaaa
    10381 tttagataaa attattgaca agattcggca aaaatatggt tttacgtcga ttgtacatgc
    10441 ttcttcaatg ttagaaggcg ctagaagcat tactagaagc acacttgttg gtggtcatgc
    10501 gggcggaaat gggggaatta aaaatgattg attacaatga tcgtggacgt ttaaagtggg
    10561 cagggtttta tttatctgat catactgaag aaattgatgc cgacaatgaa caacgaacca
    10621 gtcaaaattt agcaaaagaa caaatgacga ctgaagagat tgcggaagta ttgaacgctg
    10681 cagtcataaa aaatagatca gtatctattc aaaaagaaga acgaaacgct gaaggatact
    10741 atccagaaga tatcattggc aagatcttag gtagtgatga gctggggatc tacgttggaa
    10801 aagacaaaat tcactacgac gaaatacgtc atatcgaatt ttaccaggat aataaatgga
    10861 gtcgattaga atgaacatta tccagcaata tgagctaaag tatataacct ttgatcagct
    10921 atcagaagag atttggggtt atggccaacg tttgataaat gaggttggtg ttgagcgctt
    10981 ctctttctat gtagaagctg cagcaggtta tcataatttt aggttttata tcttcccgtt
    11041 atatatataa ggtattttac ggattctata gagttatctc tatgaatcct tttttgtttt
    11101 tacaaatagg agtagatact agaataatgc gtgtgttaaa ctattattgc aaacgcaata
    11161 ataaaagaaa gtaggcttac gcaccatgtc tatcaataca tttgtttact cgcacccgat
    11221 caatgtttac attatcaaga atttaggaat cactgtagaa caattttgtg agttatatgc
    11281 ctacccacaa ggaacggttg caagctggat aacccgacaa cgtagaataa aatcattacc
    11341 tgcttcattc gtttatgatt taagcctggc ctctagttta aacatgtctg atgtttatga
    11401 aaagctcctg tctttagaaa aagaatatga ttccttcaag attaaacatg ataaaaaaat
    11461 aaaaaaacat atataatatc aatcacaatt gtataatatt acgatatctt aatatcatga
    11521 tatcgtaata ttgttttttt ctaagaaaat gcactataag aagggaatta ttagtaacaa
    11581 tatagacagt ttagtaatgt ttaaattatt ctagttgctg ctcgcaaaac atatttctta
    11641 tcattaataa aaaattttaa agtaataaaa agtgattatt ttaatttcga ataacatatg
    11701 aataatcttt atatccgaac cgatatatat ctttaaaaca aaataatcac acaatattac
    11761 aatataatgc atatacgata ttgcaatatc acaatattat gatataatta tattataata
    11821 taagatgaat gggggatatt ttaatggcaa gaatattgtc agtagccaat caaaaaggtg
    11881 gagtttctaa aactacgact agcgttaatt tagcagcatg tttgaaattt gtttacggta
    11941 aaaatgtact tttagtggac attgatcctc agggaaatgc tacagataat gtaggtttcg
    12001 atatagatgg aacaaaccaa cctacaattt atgaagtatt aaaaggggag gctgacatta
    12061 cagatgctat tctggactat aaaggaattg atgttttgcc agccgacata gccctttctt
    12121 ctgcagagag ggaatttact caagtaggaa gtgaacacag gcttaaaaga gtacttcaac
    12181 caatcaagga caactatgat tatattataa ttgattgtcc accaagttta ggaatgctta
    12241 cagtcaacgc atttactgtt tctgatgaaa ttatcattcc agttgaagct gcgtatttct
    12301 cattaaaagg actaataaag ttaagtgaaa ctattgaaac ggtaaaagaa tatacgaacg
    12361 acaagcttga agtacgagga gttctattta ctaagtataa taagcgttat aacatttcta
    12421 aagaaatgac gtctgcagca accgaaattt ctagagtcat tggtgcaaaa attttcaaaa
    12481 cttatattcg taggacaata accgttgacg aagcgcaagc tgctggatca gatctaatca
    12541 attttaataa accctcaaca gctgaagatg actataaagc atttacagaa gaatatttaa
    12601 aagaagttgg tgattttgat ggcagaagat aatcgcagtc aagctgcagt aagtagatta
    12661 ctaggaaata aaaataaaaa gaattttaaa tcaaaagaag tagaagaaat cgaattaacc
    12721 aagaaaaata taagtaaagt cataaaagat caaggaagta gtgtaagaac agcagatagc
    12781 attcgtataa atccaattct aatgtcagca ctcaaatatt ggacgactat tgctgaatca
    12841 gacaaaagta aaccagacgt tatagaagat gcgctattaa agtccatacc tgaagaatac
    12901 ttgattgaag gatataaact agcaaagaaa caaaataaaa tttaatttac attcaatatc
    12961 acgatatcat aatatcgtga tatttttttt ataaaaatca gtagtatcaa agctgataag
    13021 tcgcttatct tcatattgta atattacgat atcgtgatat aatattattg taatatcgtg
    13081 atatagttac tatgagctta aaccttgaaa tagagcggtt tgctttaatt tattttttaa
    13141 ggtaaactaa aaaaagataa aaaaagacta ctgctttaac aaagtttggc gacttatcag
    13201 cagtagaaaa atatatagtg gatagatata tttgtttaat tcattgtaac atagttttga
    13261 acaaaacgct atcctacaga aagaggattg gctatgaatg attttaatta ttacaaatca
    13321 aaagaaattt atcgtgaaaa atattatcaa atgcctaagg tattttttac taacgaaaaa
    13381 tacatggatc tatcaaatga tgcaaaaatt gcttatatgc tacttaaaga tcgatttgat
    13441 tattcagtca aaaataactg ggtagattct gatgataata tatttttcat attcacagtt
    13501 gaagaattaa tgaaattgtt acaatgccgc gaaggtaaag tatctaaaat caaaaaggaa
    13561 ttagaaaaag caggtcttct gaaacagaag agaggaagag taaataaacg tgacggtaag
    13621 attgaatcca tgcctaattt attgtactta ggcaagccag aagtaacgaa tcaagacgtc
    13681 tttaaaatca tggaagagga agacaatact gataccaccg taattgcgaa aatcgcaaat
    13741 acggcaaaac cgcgagaaat caatgatacc accgtaattg cgaaaatcgc aaatacggca
    13801 aaatccagtc atatcaagga ctcaaccgta attgcgaaaa tcgcagacaa tctattctat
    13861 tctaattcta tagacactaa tagacacata atagacactg aaactgatca gttacaaaat
    13921 caagttttac tagataactt cgtcgacatc atgaaagagg acagtataaa tacatttgta
    13981 ccagaaaatg tattaaactt gataaaaaca ttttctagta cttacgaaga cgctcaaaaa
    14041 accgtccaaa ctattcataa tgcaaagaaa aaagctgaag aattagagca aacagttgtt
    14101 gtttatgaag aactggaatc ttatggaatt gatgctgaca aaggattata tatgactttg
    14161 ctgaaagctt atcaaaaaca aaaaactgaa aaagtaaaca atttgcagaa tctaattttc
    14221 gtttatgtaa aaaattggtt tgtcgaaaaa gctattgcgg caaagcttgc aaacgaacaa
    14281 agagaaacat ttaacgaatt accaacagtt agtacggaaa attggctaga gtagttgata
    14341 aaaagcgatc actataaaaa tgatcaattt taaattagaa cttttttatg attttaattt
    14401 tattacaaat gttacaaata aatagctatt attccggagt ttttagatta aaagtttatg
    14461 aaaacaatca caaacgtagg ttttaaagtc ataatcgtta gatattttag ttatttttca
    14521 ttcaaaaaaa tagggaacta gtgtttgcat atgtgctttt ttgagttata ataattcatg
    14581 aagagaggta attcacttat ttccccaagc tgaaaagcct gatattactt cttttcaggc
    14641 agtgctgcta atattcaatt acactttttt gtatattttt agttgtttta aatttaattg
    14701 tctgatatgc ttgtgatgaa ttgattttcg ttctgcactt ttggacgata aattgtgata
    14761 attgaaaata caaaaaaaag aaaggcccct gtaaggctcg ggagactggt aatctccgtc
    14821 agtgtcctac aggaaagcat taagatgacg ccttaatgcg tgcccttcag tgttacggta
    14881 ttacccgcaa cggacggttc tgttgcaaag ttttaaataa agaataaaat cccttacggt
    14941 atctatgatt taagctggga ttcccaataa taccttgatt tcagtacaga ccgaaaaccc
    15001 gaagagagtg ccttcttttc gggttttctt atataatcct cgaatggctt ccatgccttt
    15061 aatcgtggta gaggcagtgc gtaaacttcg atagaattta ttgcgtctct ttactggacg
    15121 atggtcttgt tcaatcaaat tattcaggta tttaatggta cgatgttctg tcccttgata
    15181 aaagccgtat tcttttagtt tcttaaaggc acttgtaata gagggggctt tatctgtgac
    15241 tacaaccttc ggttcatcaa actgcttcac taaccgctta agaaaagcat aggctgcttg
    15301 tgtgtcccgt tttttacgta accaaatatc caaggttaaa ccatctgcat cgatggctcg
    15361 atacaaataa tgccattttc ctttaatttt gatgtacgtt tcatccattt tccatgaata
    15421 aaaggatttt ttatttttct ttttccaaat ttgatagagt agtttgccat attcttgcac
    15481 ccaacgataa atcgtcgtat gagaaacgtt aatgccacga tcatataaga tttcttgaac
    15541 ttcacgatag ctaaggttat aacgaagata gtagcccacg gctacaataa tcacatcctg
    15601 ctgaaattgc tttcctttaa aatgattcat cgtcattcct cctgctatct ttttctatta
    15661 ttctacctta tttgatagta gatttaaaac tttgcaacag aaccactcga atcactcgta
    15721 gtacacaaga tctatttgaa ttaatcgata acatacgaga taaaaaggca agtttaaaat
    15781 cactaaaaga tacatggctt gatttatcag aagataatcc atacagccaa ttcttaatta
    15841 ctgtaatggc tggtgttaac caattagagc gagatcttat tcggatgaga caacgtgaag
    15901 ggattgaatt ggctaagaaa gaaggaaagt ttaaaggtcg attaaagaag tatcataaaa
    15961 atcacgcagg aatgaattat gcggtaaagc tatataaaga aggaaatatg actgtaaatc
    16021 aaatttgtga aattactaat gtatctaggg cttcattata caggaaatta tcagaagtga
    16081 ataattagcc attctgtatt ccgctaatgg gcaatatttt taaagaagaa aaggaaacta
    16141 taaaatatta acagcctcct agcgatgccg aaaagccctt tgataaaaaa agaatcatca
    16201 tcttaagaaa ttcttagtca tttattatgt aaatgcttat aaattcggcc ctataatctg
    16261 ataaattatt aagggcaaac ttatgtgaaa gggtgataac tatgagcgat aaaatactta
    16321 ttgtggatga tgaacatgaa attgccgatt tggttgaatt atacttaaaa aacgagaatt
    16381 atacggtttt caaatactat accgccaaag aagcattgga atgtatagac aagtctgaga
    16441 ttgaccttgc catattggac atcatgcttc ccggcacaag cggccttact atctgtcaaa
    16501 aaataaggga caagcacacc tatccgatta tcatgctgac cgggaaagat acagaggtag
    16561 ataaaattac agggttaaca atcggcgcgg atgattatat aacgaagccc tttcgcccac
    16621 tggagttaat tgctcgggta aaggcccagt tgcgccgata caaaaaattc agtggagtaa
    16681 aggagcagaa cgaaaatgtt atcgtccact ccggccttgt cattaatgtt aacacctatg
    16741 agtgttatct gaacgagaag cagttatccc ttactcccac cgagttttca atactgcgaa
    16801 tcctctgtga aaacaagggg aatgtggtta gctccgagct gctatttcat gagatatggg
    16861 gcgacgaata tttcagcaag agcaacaaca ccatcaccgt gcatatccgg catttgcgcg
    16921 aaaaaatgaa cgacaccatt gataatccga aatatataaa aacggtatgg ggggttggtt
    16981 ataaaattga aaaataaaaa aaacgactat tccaaactag aacgaaaact ttacatgtat
    17041 atcgttgcaa ttgttgtggt agcaattgta ttcgtgttgt atattcgttc aatgatccga
    17101 gggaaacttg gggattggat cttaagtatt ttggaaaaca aatatgactt aaatcacctg
    17161 gacgcgatga aattatatca atattccata cggaacaata tagatatctt tatttatgtg
    17221 gcgattgtca ttagtattct tattctatgt cgcgtcatgc tttcaaaatt cgcaaaatac
    17281 tttgacgaga taaataccgg cattgatgta cttattcaga acgaagataa acaaattgag
    17341 ctttctgcgg aaatggatgt tatggaacaa aagctcaaca cattaaaacg gactctggaa
    17401 aagcgagagc aggatgcaaa gctggccgaa caaagaaaaa atgacgttgt tatgtacttg
    17461 gcgcacgata ttaaaacgcc ccttacatcc attatcggtt atttgagcct gcttgacgag
    17521 gctccagaca tgccggtaga tcaaaaggca aagtatgtgc atatcacgtt ggacaaagcg
    17581 tatcgactcg aacagctaat cgacgagttt tttgagatta cacggtataa cctacaaacg
    17641 ataacgctaa caaaaacgca catagaccta tactatatgc tggtgcagat gaccgatgaa
    17701 ttttatcctc agctttccgc acatggaaaa caggcggtta ttcacgcccc cgaggatctg
    17761 accgtgtccg gcgaccctga taaactcgcg agagtcttta acaacatttt gaaaaacgcc
    17821 gctgcataca gtgaggataa cagcatcatt gacattaccg cgggcctctc cggggatgtg
    17881 gtgtcaatcg aattcaagaa cactggaagc atcccaaaag ataagctagc tgccatattt
    17941 gaaaagttct ataggctgga caatgctcgt tcttccgata cgggtggcgc gggacttgga
    18001 ttggcgattg caaaagaaat tattgttcag catggagggc agatttacgc ggaaagcaat
    18061 gataactata cgacgtttag ggtagagctt ccagcgatgc cagacttggt tgataaaagg
    18121 aggtcctaag agatgtatat aattttggct ctttgtcaaa tgatgttggt aaagagaaat
    18181 cttagaataa ttggagatca agtggatcag ttcctcttga tcttttttag ttgaaaatca
    18241 atgcgttgcc atgacgaatc atgatgcgca atttgaaatt ataaaagcta cgaaagccat
    18301 atgcatttcg ttttaacact ttgatatggt tgttcagaca ttcaagtggg ccatttgaat
    18361 aactttgttg taaagcattt ttgatttgtg gcagaaattt ctggaacgtt ctcaaggtcg
    18421 tctgatagcc ttcgggaagc atgatattat tggtaagtag ttcttcaaac gatacgtagt
    18481 ctcgttcctt tacagcgtaa agaaagtctt gatataactg atagcctaca cgcaaagcag
    18541 ggctcccttt cagtaagcga tccacaatat cggtctctgt taaatgagct ttgaagccag
    18601 gtcgccaaag gcgtcgagta taatcaagct tgcgttcatc tttttgaaga agtttccagt
    18661 atctttttaa ttgcttacct aattgatagt gtttttgttc tttgcttttt aatagttggt
    18721 tcgtttcttt gattcgatga ttgcgaaagg tacgaccaat atgttggacg atgtgaaacc
    18781 ggtcaataat cagctgtgct tttggaaaca gctttttaac gagcgataca taaggagcgt
    18841 acatatcaat cacgatccat tcgaccgctt cacgaatttc tcgtgaaaaa tgactaaaat
    18901 aacgttttaa aaaaggcagt tgtcggttct cgacaatgtc caataagcgc tgtgtttgtc
    18961 catccatcat gatgaaactc atagcacctg aaacaccccg aactgatttg aattcatcaa
    19021 aacaaagtac cttaggtaac ggtgtccgaa aaggattcaa cggacgataa aatcgcttca
    19081 taatacggta aacagaagag accgatagat ttttctgagc ggcgatctct gtcattgagg
    19141 tatttttttt cagacgagtc acgacagacc agcggacttt ctcactgatg aaacaatgtt
    19201 ttttcgcaac agaagtatct gcgacaaagg tccgctgaca agctttgcat ttgaagcgtt
    19261 gctttttcaa ttcgaggtag gtacggtatt cagaaacatc gttcattaac aaccggacgg
    19321 ttgttgtacc ccaacgcaca atatctgaag caatctggtg tttacagtgg atgcattctt
    19381 gggctgtata aatcaagttt ccacgataaa tatgacagat ttgccctttg tatttttctt
    19441 ttgtgagaca attttcgtta aaagtaactg ataagtctag aatatctaat gtttctttga
    19501 taaggtgagt gtaagacatc ttgattcctc cttttgggtt ggttcgccaa attaattcta
    19561 aaggatttca aggtgtcttt tctatatgtt ttggaaaata aaaaagatgc tggtgtcatc
    19621 caccaacatc aaaaagtata gagccataat tttttaggaa aatctcaagg ttatctttac
    19681 tttttcttag gaaattaaca atttaatatt aagaaacggc tcgttcttac acggtagact
    19741 taataccgta agaacgagcc gttttcgttc ttcagagaaa gatttgacaa gattaccatt
    19801 ggcatccccg ttttatttgg tgcctttcac agaaagggtt ggtcttaatt atgaataaca
    19861 tcggcattac tgtttatgga tgtgagcagg atgaggcaga tgcattccat gctctttcgc
    19921 ctcgctttgg cgttatggca acgataatta acgccaacgt gtcggaatcc aacgccaaat
    19981 ccgcgccttt caatcaatgt atcagtgtgg gacataaatc agagatttcc gcctctattc
    20041 ttcttgcgct gaagagagcc ggtgtgaaat atatttctac ccgaagcatc ggctgcaatc
    20101 atatagatac aactgctgct aagagaatgg gcatcactgt cgacaatgtg gcgtactcgc
    20161 cggatagcgt tgccgattat actatgatgc taattcttat ggcagtacgc aacgtaaaat
    20221 cgattgtgcg ctctgtggaa aaacatgatt tcaggttgga cagcgaccgt ggcaaggtac
    20281 tcagcgacat gacagttggt gtggtgggaa cgggccagat aggcaaagcg gttattgagc
    20341 ggctgcgagg atttggatgt aaagtgttgg cttatagtcg cagccgaagt atagaggtaa
    20401 actatgtacc gtttgatgag ttgctgcaaa atagcgatat cgttacgctt catgtgccgc
    20461 tcaatacgga tacgcactat attatcagcc acgaacaaat acagagaatg aagcaaggag
    20521 catttcttat caatactggg cgcggtccac ttgtagatac ctatgagttg gttaaagcat
    20581 tagaaaacgg gaaactgggc ggtgccgcat tggatgtatt ggaaggagag gaagagtttt
    20641 tctactctga ttgcacccaa aaaccaattg ataatcaatt tttacttaaa cttcaaagaa
    20701 tgcctaacgt gataatcaca ccgcatacgg cctattatac cgagcaagcg ttgcgtgata
    20761 ccgttgaaaa aaccattaaa aactgtttgg attttgaaag gagacaggag catgaataga
    20821 ataaaagttg caatactgtt tgggggttgc tcagaggagc atgacgtatc ggtaaaatct
    20881 gcaatagaga tagccgctaa cattaataaa gaaaaatacg agccgttata cattggaatt
    20941 acgaaatctg gtgtatggaa aatgtgcgaa aaaccttgcg cggaatggga aaacgacaat
    21001 tgctattcag ctgtactctc gccggataaa aaaatgcacg gattacttgt taaaaagaac
    21061 catgaatatg aaatcaacca tgttgatgta gcattttcag ctttgcatgg caagtcaggt
    21121 gaagatggat ccatacaagg tctgtttgaa ttgtccggta tcccttttgt aggctgcgat
    21181 attcaaagct cagcaatttg tatggacaaa tcgttgacat acatcgttgc gaaaaatgct
    21241 gggatagcta ctcccgcctt ttgggttatt aataaagatg ataggccggt ggcagctacg
    21301 tttacctatc ctgtttttgt taagccggcg cgttcaggct catccttcgg tgtgaaaaaa
    21361 gtcaatagcg cggacgaatt ggactacgca attgaatcgg caagacaata tgacagcaaa
    21421 atcttaattg agcaggctgt ttcgggctgt gaggtcggtt gtgcggtatt gggaaacagt
    21481 gccgcgttag ctgttggcga ggtggaccaa atcaggctgc agtacggaat ctttcgtatt
    21541 catcaggaag tcgagccgga aaaaggctct gaaaacgcag ttataaccgt tcccgcagac
    21601 ctttcagcag aggagcgagg acggatacag gaaacggcaa aaaaaatata taaagcgctc
    21661 ggctgtagag gtctagcccg tgtggatatg tttttacaag ataacggccg cattgtactg
    21721 aacgaagtca atactctgcc cggtttcacg tcatacagtc gttatccccg tatgatggcc
    21781 gctgcaggta ttgcacttcc cgaactgatt gaccgcttga tcgtattagc gttaaagggg
    21841 tgataagcat ggaaatagga tttacttttt tagatgaaat agtacacggt gttcgttggg
    21901 acgctaaata tgccacttgg gataatttca ccggaaaacc ggttgacggt tatgaagtaa
    21961 atcgcattgt agggacatac gagttggctg aatcgctttt gaaggcaaaa gaactggctg
    22021 ctacccaagg gtacggattg cttctatggg acggttaccg tcctaatcgt gctgtaaact
    22081 gttttatgca atgggctgca cagccggaaa ataacctgac aaaggaaagt tattatccca
    22141 atattgaccg aactgagatg atttcaaaag gatacgtggc ttcaaaatca agccatagcc
    22201 gcggcagtgc cattgatctt acgctttatc gattagacac gggtgagctt gtaccaatgg
    22261 ggagccgatt tgattttatg gatgaacgct ctcatcatgc ggcaaatgga atatcatgca
    22321 atgaagcgca aaatcgcaga cgtttgcgct ccatcatgga aaacagtggg tttgaagcat
    22381 atagcctcga atggtggcac tatgtattaa gagacgaacc ataccccaat agctattttg
    22441 atttccccgt taaataaact tttaaccgtt gcacggacaa actatataag ctaactcttt
    22501 cggcaggaaa cccgacgtat gtaactggtt cttagggaat ttatatatag tagatagtat
    22561 tgaagatgta aggcagagcg atattgcggt cattatctgc gtgcgctgcg gcaagatagc
    22621 ctgataataa gactgatcgc atagaggggt ggtatttcac accgcccatt gtcaacaggc
    22681 agttcagcct cgttaaattc agcatgggta tcacttatga aaattcatct acattggtga
    22741 taatagtaaa tccagtaggg cgaaataatt gactgtaatt tacggggcaa aacggcacaa
    22801 tctcaaacga gattgtgccg tttaagggga agattctaga aatatttcat acttccaact
    22861 atatagttaa ggaggagact gaaaatgaag aagttgtttt ttttattgtt attgttattc
    22921 ttaatatact taggttatga ctacgttaat gaagcactgt tttctcagga aaaagtcgaa
    22981 tttcaaaatt atgatcaaaa tcccaaagaa catttagaaa atagtgggac ttctgaaaat
    23041 acccaagaga aaacaattac agaagaacag gtttatcaag gaaatctgct attaatcaat
    23101 agtaaatatc ctgttcgcca agaaagtgtg aagtcagata tcgtgaattt atctaaacat
    23161 gacgaattaa taaatggata cgggttgctt gatagtaata tttatatgtc aaaagaaata
    23221 gcacaaaaat tttcagagat ggtcaatgat gctgtaaagg gtggcgttag tcattttatt
    23281 attaatagtg gctatcgaga ctttgatgag caaagtgtgc tttaccaaga aatgggggct
    23341 gagtatgcct taccagcagg ttatagtgag cataattcag gtttatcact agatgtagga
    23401 tcaagcttga cgaaaatgga acgagcccct gaaggaaagt ggatagaaga aaatgcttgg
    23461 aaatacgggt tcattttacg ttatccagag gacaaaacag agttaacagg aattcaatat
    23521 gaactatggc atattcgcta tgttggttta ccacatagtg cgattatgaa agaaaagaat
    23581 ttcgttctcg aggaatatat ggattaccta aaagaagaaa aaaccatttc tgttagtgta
    23641 aatggggaaa aatatgagat cttttattat cctgttacta aaaataccac cattcatgtg
    23701 ccgactaatc ttcgttatga gatatcagga aacaatatag acggtgtaat tgtgacagtg
    23761 tttcccggat caacacatac taattcaagg aggtaaggat ggcggaatga aaccaacgaa
    23821 attaatgaac agcattattg tactagcact tttggggtaa cgttagcttt ttaatttaaa
    23881 acccacgtta actaggacat tgctatacta atgatacaac ttaaacaaaa gaattagagg
    23941 aaattatatt gggaaaaata ttatctagag gattgctagc tttatattta gtgacactaa
    24001 tctggttagt gttattcaaa ttacaataca atattttatc agtatttaat tatcatcaaa
    24061 gaagtcttaa cttgactcca tttactgcta ctgggaattt cagagagatg atagataatg
    24121 ttataatctt tattccattt ggcttgcttt tgaatgtcaa ttttaaagaa atcggatttt
    24181 tacctaagtt tgcttttgta ctggttttaa gtcttacttt tgaaataatt caatttatct
    24241 tcgctattgg agcgacagac ataacagatg taattacaaa tactgttgga ggctttcttg
    24301 gactgaaatt atatggttta agcaataagc atatgaatca aaaaaaatta gacagagtta
    24361 ttatttttgt aggtatactt ttgctcgtat tattgctcgt ttaccgtacc catttaagaa
    24421 taaattacgt gtaagatgtc taaatcaagc aatctgatct ttcatacaca taaagatatt
    24481 gaatgaattg gattagatgg aaaacgggat gtggggaaac tcgcccgtag gtgtgaagtg
    24541 aggggaaaac cggtgataaa gtaaaaagct tacctaacac tatagtaaca aagaaagccc
    24601 aattatcaat tttagtgctg aggaattggt ctctttaata aatttcctta acgttgtaaa
    24661 tccgcatttt cctgacggta cccccaaact aagatttcat agatagattt tctgataact
    24721 ttaaaaaaca cgaatagcgg aaaggatgtc ttcattcgct aaagagtaat aaactacttt
    24781 tccatcttga cgtgattttg ccattccatg tttttttaaa aaacgtaaat ggtgtgacgt
    24841 tgtagcgaca ctagcagtaa gtatttctgc taaatcacag acgcacattt ccttataggt
    24901 ttctaaagca tagaaaattt taattctaga aaaatcgctg aaacatttcc ctaacacaag
    24961 taagtttgaa aaatcttttt gatccaattt attttttatt ccatttactt tttctttatg
    25021 tacgacagtc acttggcaaa cttttttcat tcatctcacc tcacattcaa acgattattt
    25081 gaatgaagta tacctatttg atcactcttt tgtcaatcta ccttaattcc aatacactat
    25141 tataagcaat ttcatgtatt gaagtaaact tacttgcaag tgcgtttttg attccaagtt
    25201 aaaaacatat tattattcta cataatttcc taatcaaata aaactccttt gaaaattgtt
    25261 ctaaaggagt tttattattt tgtatttcta ctaaaaatag cgtacaatgt aattactaag
    25321 taattacgaa atgtaaaata atggaggaaa taatatgatt acaaaaacaa gaaaacaagg
    25381 aaattctatt atgttaacgg tccctaaaga attcgatgtg cccaatggtg ttgaagtaga
    25441 agctaagctt gtagagaatg gtatccttta tgagtttgta gagcctaaaa aagaattttt
    25501 tgattttagt gaagatattt tggctgatat tctttcagaa ggttatagca aacaagagat
    25561 cttaaaagaa tttagaaata gaaaaaatgc gttaacttct gcatttaaat ctattgctga
    25621 agatactgtt gcaaattcta aaccgatgac aaaagaggag ttggcagcag aaattggctt
    25681 atgagattct accttctaaa cacgtaataa agtatctaaa aaaattaaaa gagaaaacat
    25741 taaaagaaca atttttaacg ataatttatg atgagatagc agttcgtcct cattcgggag
    25801 aacaaaaaac gggtgattta tcaggaattt gggctattgg attcaagtat gcaggtacga
    25861 catatcgcgt tgcatatgaa attaaagata atgcagtgat acctaactta ctatgtggaa
    25921 cgcatgaaaa tttttatgaa caattaaaaa agattaggta agaacccaat gtttcaactt
    25981 gagaggatag acgacacttt aaaagataat ttttaacagc tgagagttgt aataccctat
    26041 aattttaaac cactaaccta tatatttatg aaaaatagaa aaaattaaaa cgcattttaa
    26101 gcctctttca aattaaaagc ttcatcctta tgcacaaaga gggcttaaaa tgcgttattt
    26161 tatattgttt tttagtaata ataaaaaaat cactctaatt ctcccataaa tattatagat
    26221 tcctaaagat taaaatagat tattccctat tgtcttttaa gtagcggtag agtgttgcct
    26281 tgctaatacc agtcatttcc gtaatttctt ttacgctata aacctgactt ttatacaatt
    26341 ttactgctcg atcaacatct ttctggttca ctcgtggacg gcccctttac gacctctcgc
    26401 acgtgcactt ttcaaacctt ctttggtacg ttcaacaatt aaatcacgtt cgaactgact
    26461 aaatgcttgg aagacagtca tcattaagcg tccgtgaggc gtgctggtat cgaagttttc
    26521 tttcaagctc accagcttaa catggtgttc ttcaaaatag gtaacaaggt caatcaaatc
    26581 ctttgtacta cgacccaatc gagaaaaact ttctacaatt accgtatctc ccggacgaat
    26641 tttatctttt aaacgattta gttggggacg aaccgctttg gttcccgtca ttttctcagt
    26701 taggatttca ttacaatttt gttcattgag taagtcggtt ctgttgcaaa gttttaaata
    26761 aagaataaaa tcccttacgg tatctatgat ttaagctggg attcccaata ataccttgat
    26821 ttcagtacag accgaaaacc cgaagagagt gccttctttt cgggttttct tatataatcc
    26881 tcgaatggct tccatgcctt taatcgtggt agaggcagtg cgtaaacttc gatagaattt
    26941 attgcgtctc tttactggac gatggtcttg ttcaatcaaa ttattcaggt atttaatggt
    27001 acgatgttct gtcccttgat aaaagccgta ttcttttagt ttcttaaagg cacttgtaat
    27061 agagggggct ttatctgtga ctacaacctt cggttcatca aactgcttca ctaaccgctt
    27121 aagaaaagca taggctgctt gtgtgtcccg ttttttacgt aaccaaatat ccaaggttaa
    27181 accatctgca tcgatggctc gatacaaata atgccatttt cctttaattt tgatgtacgt
    27241 ttcatccatt ttccatgaat aaaaggattt tttatttttc tttttccaaa tttgatagag
    27301 tagtttgcca tattcttgca cccaacgata aatcgtcgta tgagaaacgt taatgccacg
    27361 atcatataag atttcttgaa cttcacgata gctaaggtta taacgaagat agtagcccac
    27421 ggctacaata atcacatcct gctgaaattg ctttccttta aaatgattca tcgtcattcc
    27481 tcctgctatc tttttctatt attctacctt atttgatagt agatttaaaa ctttgcaaca
    27541 gaaccaacgg aattaacagt caaatatcaa aatgaattga atttagtacc gctgaaaaat
    27601 ttcaatgcta agcagatgga tttatttttt gcattatgcg ctcgtatgaa agatcgtggt
    27661 ttgaaaaaag ttagattttc tttcgaggaa ttaaaagagt taagtgatta taagatgact
    27721 gctacaaaag cctttgtcgg tgatttagaa aagctctata aagatatgct taatcttact
    27781 taccgtactg aagatgagga ttctattcgc tactttgttt tgtttactgg ttttgaaatc
    27841 aataaaacaa aaaagtttgt tgaagtcagt gttaatccgg acctagaata tattattaat
    27901 ggtttaacag ctgaatttag tagatttgaa ttatctgctt tcacgtcgtt gcgttctacg
    27961 tatgcaaaaa ctctattccg actgcttatg cagtaccgtt ctactggtta ttatgtagtt
    28021 cgtattgaag agtttaggag cttaatggat atcccagaat actatcaaat gggtaacatt
    28081 gatcaaaaag tattaaatcc tgcattacga gaactaaaaa aatacttcaa tgatcttaaa
    28141 gtcacaaaaa taaaagcaaa aaagggcaat aaaatcgcca aattagaatt tactttttca
    28201 agcctaacgt cagatttgcc aaagatttct ctgcgtaact ggttagaaga ataaataaaa
    28261 aagaactcgc cccccttaca ttaagcaagt agacaagtcc cttacaaccg actaagattg
    28321 ctagtacatt ctagcatatt gtatggggct tctaaataaa aaacagatag gagttattcc
    28381 tatctgtttt ttatcgtttt agaaaatttg ttgggtcgaa atttctagaa gtgactgttt
    28441 gactggtttc tttttgatga ttctttggtc gatttcgatt tgatggattt a
//
