LOCUS       NZ_AP022193            27833 bp    DNA     circular CON 02-DEC-2023
DEFINITION  Klebsiella sp. WP7-S18-CRE-02 plasmid pWP7-S18-CRE-02_4, complete
            sequence.
ACCESSION   NZ_AP022193
VERSION     NZ_AP022193.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMD00194568
            Sequence Read Archive: DRR199404
            Assembly: GCF_014169515.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella sp. WP7-S18-CRE-02
  ORGANISM  Klebsiella sp. WP7-S18-CRE-02
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1
  AUTHORS   Sekizuka,T., Itokawa,K., Yatsu,K., Inamine,Y. and Kuroda,M.
  TITLE     complete genome sequences of Klebsiella sp. WP7-S18-CRE-02 isolated
            from wastewater treatment plant effluent
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 27833)
  AUTHORS   Sekizuka,T., Itokawa,K., Yatsu,K., Inamine,Y. and Kuroda,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-DEC-2019) Contact:Tsuyoshi Sekizuka National Institute
            of Infectious Diseases, Pathogen Genomics Center; 1-23-1 Toyama,
            Shinjuku-ku, Tokyo 162-8640, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: flye v2.5; minimap v0.2-r124; racon v1.1.0;
            circlator v1.5.3; Pilon v1.18; SPAdes v3.11.1; A5-miseq v20140604
            Genome Coverage                   :: 239x
            Sequencing Technology             :: Sequel; NextSeq 500
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 12/02/2023 11:36:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,143
            CDSs (total)                      :: 5,025
            Genes (coding)                    :: 4,879
            CDSs (with protein)               :: 4,879
            Genes (RNA)                       :: 118
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 7
            Pseudo Genes (total)              :: 146
            CDSs (without protein)            :: 146
            Pseudo Genes (ambiguous residues) :: 0 of 146
            Pseudo Genes (frameshifted)       :: 44 of 146
            Pseudo Genes (incomplete)         :: 101 of 146
            Pseudo Genes (internal stop)      :: 20 of 146
            Pseudo Genes (multiple problems)  :: 16 of 146
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP022193.1.
            Annotated by DFAST v.1.2.3 (https://dfast.nig.ac.jp).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..27833
                     /organism="Klebsiella sp. WP7-S18-CRE-02"
                     /mol_type="genomic DNA"
                     /strain="WP7-S18-CRE-02"
                     /isolation_source="wastewater"
                     /db_xref="taxon:2675716"
                     /plasmid="pWP7-S18-CRE-02_4"
                     /geo_loc_name="Japan:Tokyo"
                     /lat_lon="35.5619 N 139.7531 E"
                     /collection_date="2018-08-06"
     gene            complement(join(27457..27833,1..100))
                     /locus_tag="H7R68_RS25475"
     CDS             complement(join(27457..27833,1..100))
                     /locus_tag="H7R68_RS25475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009268104.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="WP_218188518.1"
                     /translation="MNLTDGVLAALLLGGWYGGFAGAIGMTIADLLDPVYITVAPKTFV
                     LKLCIGLITGLVAHNFAKINHSNNKGYVFKWVLISSICGLTFNVIFDPIVGYFYKLYIL
                     GQPQELASILAKLSAVTTFINAVVSVILVSLIYNSIISPLKKSGFLLIENKEDN"
                     /name="ECF transporter S component"
     gene            <98..>643
                     /locus_tag="H7R68_RS25480"
                     /old_locus_tag="WP7S18C02_P40010"
                     /pseudo=""
     CDS             <98..>643
                     /locus_tag="H7R68_RS25480"
                     /old_locus_tag="WP7S18C02_P40010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011349284.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3 family transposase"
                     /name="Tn3 family transposase"
     gene            1028..2431
                     /locus_tag="H7R68_RS25485"
                     /old_locus_tag="WP7S18C02_P40020"
     CDS             1028..2431
                     /locus_tag="H7R68_RS25485"
                     /old_locus_tag="WP7S18C02_P40020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001567368.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISNCY-like element ISKpn21 family transposase"
                     /protein_id="WP_182928924.1"
                     /translation="MSAESSGVFTLKEINRIKIIQDVIERRITTRRAAEHLGISDRQCR
                     RLLARYREGGPLGMASRRCGMRGNRQLPPGLADQALELIKTRYADFGPTLAREKLEELH
                     GLFLGKETVRRIMVRAGLWVPRKQRAARIPQPRYRRPCTGELIQIDGCDHDWFEGRGPA
                     CTALVYVDDATSKLMELLFVKSESTFSYFEATRRYINKHGKPLALYSDKAGVFRVNNKH
                     ATGGDGHTQFGRAMHELNIQTICAETSPAKGRVERAHLTLQDRLVKELRLQGICSMEAA
                     NDFAEAYMADYNRRFGKVPRHDFDVHRAVEHDEDLGLIFTVREKRKVSKSLTIQYDKML
                     YLIEDSELSRRAIGKYIDVYHYPDGRKELRLNGTLLPYSTYDRLSEIDQGAIVDNKRLG
                     RTLEFISLVQSKRDNTRSQSIPAGDGPSRRRPKQEGKKSQRSLDNDDMLEALKQLQSRS
                     EDIFGKRAR"
                     /name="ISNCY-like element ISKpn21 family transposase"
     gene            complement(2460..3092)
                     /locus_tag="H7R68_RS25490"
                     /old_locus_tag="WP7S18C02_P40030"
     CDS             complement(2460..3092)
                     /locus_tag="H7R68_RS25490"
                     /old_locus_tag="WP7S18C02_P40030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004883463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001567369.1"
                     /translation="MLRYELTPNNAGFILWGDSEALNELHELIHYIVDESPLIKVKDGF
                     MLSLAYDIRKAREGNRRVEQHQYDQHDTYKLYGVELLWPLVLVQSSILRNSMGYIQTDK
                     NQLSVMYAFEYLIESALTESERTTSNDIMLTVKYASDSDFNFIEDNIDSRCCYFISLSP
                     EQRKKQLISIVRSFHSLWGKYAREKQDIKMLNEMNNTSWVWPDNINW"
                     /name="hypothetical protein"
     gene            complement(3572..3898)
                     /locus_tag="H7R68_RS25495"
                     /old_locus_tag="WP7S18C02_P40040"
     CDS             complement(3572..3898)
                     /locus_tag="H7R68_RS25495"
                     /old_locus_tag="WP7S18C02_P40040"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_227674294.1"
                     /translation="MKTMPERFIDELNKTVQGVWDDLKPTETQGKKKGQPKALPVFSIH
                     ADGLVLSVETWKNPRRVLNPLCTLQHGEIAPFWMHEAWLEAMRRIVDLLDTLTAAPAEA
                     LESQ"
                     /name="hypothetical protein"
     gene            complement(4010..>4543)
                     /locus_tag="H7R68_RS25500"
                     /old_locus_tag="WP7S18C02_P40050"
                     /pseudo=""
     CDS             complement(4010..>4543)
                     /locus_tag="H7R68_RS25500"
                     /old_locus_tag="WP7S18C02_P40050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000480972.1"
                     /GO_function="GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]; GO:0019748 - secondary metabolic process [Evidence
                     IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside phosphotransferase family protein"
                     /name="aminoglycoside phosphotransferase family protein"
     gene            complement(4576..5181)
                     /locus_tag="H7R68_RS25505"
                     /old_locus_tag="WP7S18C02_P40060"
     CDS             complement(4576..5181)
                     /locus_tag="H7R68_RS25505"
                     /old_locus_tag="WP7S18C02_P40060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001549957.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000509966.1"
                     /translation="MGHRAAIYCRVSTADQSCERQEFDLRAFAGRAGYDVVGIFKETGS
                     GTKLDRAERKKVLALAQSRQIDAILVTELSRWGRSTLDLLNTLRELENWKVSVIAMNGM
                     AFDLSSPYGRMLATFLSGIAEFERDLISERVKSGLAVAKARGKRLGRQAGVRPKSDRLL
                     PKVVAMRAEGRSYRWIARELGISKNTVADIVQRHRANA"
                     /name="recombinase family protein"
     gene            5276..8173
                     /locus_tag="H7R68_RS25510"
                     /old_locus_tag="WP7S18C02_P40070"
     CDS             5276..8173
                     /locus_tag="H7R68_RS25510"
                     /old_locus_tag="WP7S18C02_P40070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020326821.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn5403 family transposase"
                     /protein_id="WP_001553819.1"
                     /translation="MSRRHIFTERQRAALFDLPTDELSLLKFYTLGDDDLENIRQRRRP
                     ENRIGFALQLCALRYPGRALAPGEMIPREVLSFVGAQLGVPADALLTYATRRQTRQQHM
                     DTLREIYGYKTFTGRGARDLREWTFGQAEDARSNEDLAHRFIVRCRETSTILPAVSTIE
                     RLCADALVAAERRIETRIAENLTADVRDHLDKLLSEMLAGNISRFIWLRNFEVGNNSAA
                     ANRLLDRLEFLRTLNINHSALASIPAHRIARLRRQGERYFTDGLRDITSDRRWAILAVC
                     VVEWEAAIADAIVETHDRIVGKTWREAKRQHDETISGSKATLTDTIRTFTALGASLLEA
                     RSDGTPLEMAVASSVAWDRLAQLVATGTQLSNTLADEPLAYVGQGYHRFRRYAPRMLRC
                     LKLEAAPVAGPLVAAALSIGEMKGVASPERRFLRPSSKWNRHLRAQEKGDTRLWEVAVL
                     FHLRDAFRSGDVWLAHSRRYGDLKQVLVPMIAAQENAKLAVPSNPQDWLADRKARLTIA
                     LKRLARAARNGTIPHGSIEDGTLRIDRLTADVPDGAEALILDLYRRMPSVRITDMLLEV
                     DAALGFTDAFTHLRTGAPCRDRIGLLNVLLAEGLNLGLRKMAEATNTHDYWQLSRLARW
                     HVESEAMNQALAIVVAAQGKLPMSRVWGMGTSASSDGQFFPTARHGEAMNMVNAKYGSV
                     PGLKAYTHVSDQFAPFACQSIPATVSEAPYILDGLLMNEVGRHVREQYADTAGFTDHLF
                     GASSLLGYNLVLRIRDLPSKRLYVFNPDTTPRELRKLVGGKAREDLIVANWPDIFRCAA
                     TMTAGKIRPSQLLRKLASYPRQNNLAVALREVGRIERTLFIIEWILDTDMQRRAQIGLN
                     KGEAHHALKNALRIGRQGEIRDRTTEGQHYRIAGLNLLTAVIIYWNTVHLGHAVTERRN
                     EGLDVPPEFLPHISPLGWAHILLTGEYLWPKEPKA"
                     /name="Tn3-like element Tn5403 family transposase"
     gene            <8244..10163
                     /locus_tag="H7R68_RS25515"
                     /old_locus_tag="WP7S18C02_P40080"
                     /pseudo=""
     CDS             <8244..10163
                     /locus_tag="H7R68_RS25515"
                     /old_locus_tag="WP7S18C02_P40080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001138082.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3 family transposase"
                     /name="Tn3 family transposase"
     gene            complement(10077..10622)
                     /locus_tag="H7R68_RS25520"
                     /old_locus_tag="WP7S18C02_P40090"
     CDS             complement(10077..10622)
                     /locus_tag="H7R68_RS25520"
                     /old_locus_tag="WP7S18C02_P40090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_227674296.1"
                     /translation="MRIKIKGEITAERLAEALHAAAEKYEAVRPGHKVYGANLYLTAFD
                     ADGLPFDLVDHRGEPLSITIEAKSGELVKPALTAEGEAHRQKAKEEARRQAEEAEAEAQ
                     RRHRQTLDEYEQERQKRRKKEAEARKQFEDANAITAELGVVCGRGRNPTLRLWPAIFSG
                     EIDVFPSERRNMGQEIGR"
                     /name="hypothetical protein"
     gene            complement(10619..11257)
                     /locus_tag="H7R68_RS25525"
                     /old_locus_tag="WP7S18C02_P40100"
     CDS             complement(10619..11257)
                     /locus_tag="H7R68_RS25525"
                     /old_locus_tag="WP7S18C02_P40100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009873359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF6753 family protein"
                     /protein_id="WP_009873359.1"
                     /translation="MSDLDDSFAKLLGRQPSDAERQSLYRVRDALGLKNNDALWLVLMA
                     LQHYQGQYEKFPQAIAQAAKDTLVNFKVTADATVKASAEAAKADLAQAVAAAAQEVAHN
                     TSAKQMWQWAAGCIAVAFLCVGLFGWYMHSSGKDSGYQAGYGAGYTEAKDEKAAAAWAN
                     TPEGRLAYRFAQTGSLASLAKCDRPGWYVEKGVCYVKPASDGTYGWRLP"
                     /name="DUF6753 family protein"
     gene            complement(11250..11933)
                     /locus_tag="H7R68_RS25530"
                     /old_locus_tag="WP7S18C02_P40110"
     CDS             complement(11250..11933)
                     /locus_tag="H7R68_RS25530"
                     /old_locus_tag="WP7S18C02_P40110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018413461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein mobD"
                     /protein_id="WP_009873358.1"
                     /translation="MAKSIYLIGGSKGGVGKSLVTMATVDYLQERGESVLLIESDTSNP
                     DVWKAYKESTETELINLDEADGWIQLVNLCDSKPDSVVVINTAARNNKGVSAYGETLNS
                     TLEELKRKLVTLWVINRQRDSLELLKEYMDAIPNADVHVVRNGHFGEEKKFELYNGSKL
                     RTAVEERGGKSVTFPDMADRVSDDIYSKRMSIAVALKELPIGNRAELTRWRNEAKKVLE
                     AVVHE"
                     /name="protein mobD"
     gene            12266..12577
                     /locus_tag="H7R68_RS25535"
                     /old_locus_tag="WP7S18C02_P40120"
     CDS             12266..12577
                     /locus_tag="H7R68_RS25535"
                     /old_locus_tag="WP7S18C02_P40120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014003869.1"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribbon-helix-helix protein, CopG family"
                     /protein_id="WP_009873356.1"
                     /translation="MPFETQGPEPLDAVINVRLTAAEKARLKEDADLAGLSMSELVRRR
                     YFGRPIIANADAVMLKELRRIGGLLKHIHNESGGVYSKETAGALVALKDYFRKLNDDR"
                     /name="ribbon-helix-helix protein, CopG family"
     gene            12567..15239
                     /gene="traI"
                     /locus_tag="H7R68_RS25540"
                     /old_locus_tag="WP7S18C02_P40130"
     CDS             12567..15239
                     /gene="traI"
                     /locus_tag="H7R68_RS25540"
                     /old_locus_tag="WP7S18C02_P40130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018413464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraI/MobA(P) family conjugative relaxase"
                     /protein_id="WP_182930712.1"
                     /translation="MIVKKVPNPKKSASKAQRIGQLTSYVRSPESESPQEKCLYAGARG
                     FMMDDPKSQTAEMIALSQEAVRSKDTINHYVLSWREGEQPSPEQVEEAVSIFMDELGWK
                     DHQAIYGLHSDTDNIHLHIVINRVHPETLKIVEKNRGFDIELAHKAIARIEHAQGWQRE
                     QNGRYQVLENGELGRAPYDPEKPRQPDQKKRDMENRTGEKSAHRIAIEDGAAIIKQAQT
                     WEQLHRELAAKGMRYEKTGSGATVFVGDVGVKASDVDRNASLAKMQKRLGEYQPAPQRQ
                     QVAPREPEPIKPDVPGWKDYISGRKAHYAEKNADKLAQDKRQEQERKQLAEQQKARRDE
                     LMRGNWKGKGEVLNAMRSVIAAEQAAEKAALKEKHQKEREQHRQRFRPYPDLEQWQRMQ
                     KSPELAEQWRHRASEPQRIEGDRSEPPTPRDIRAYQPEIVGQQVHYSRKEEAGRGGGVS
                     FVDKGKSIDIHDWRNRDSTLAALQLSAQKWGSFTVMGNDEYKAMCGKLAAEHGFKITNP
                     ELQESIQQERQRIQQERVQAMKSEQLKQFERYAEAVGAERYRVTSIKMREDGSKQTFIL
                     DKKDGITRGFTPQEIEQRTPEMQRLQRRGENLYYTPLSDKKHHILIDDMNREKLERLIR
                     DGYQPAAVLESSPGNYQAIITVPKLGTAHDKDVGNRLSDALNREYGDPKLSGAIHPHRA
                     PGYENRKPKHQREDGSYPEVRLLKAERRECIKALALSSQIDAEYQRQAALKAQQPERSK
                     AKPALELAAASGSAIDAYQRHYRDVLKRQRGGEVDLSRLDSMIAVRMRVTGHDQAAIEG
                     AIRQCAPATRQKDEGRDWNDYAQRTARYAYSAAGDRQAAELGKYRQQWEKLEGREPVRQ
                     QEQAKAQKIERDNSPGMSL"
                     /name="traI"
     gene            15306..15530
                     /locus_tag="H7R68_RS25545"
                     /old_locus_tag="WP7S18C02_P40140"
     CDS             15306..15530
                     /locus_tag="H7R68_RS25545"
                     /old_locus_tag="WP7S18C02_P40140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011237709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin MazE family protein"
                     /protein_id="WP_043149934.1"
                     /translation="MATAHVNQRVQKHRDALRMAGLRPVQIWVPDTRRPDFAEECRRQC
                     LLVAQADSADTAMQQFMDEALADVDGWTE"
                     /name="antitoxin MazE family protein"
     gene            15527..15853
                     /locus_tag="H7R68_RS25550"
                     /old_locus_tag="WP7S18C02_P40150"
     CDS             15527..15853
                     /locus_tag="H7R68_RS25550"
                     /old_locus_tag="WP7S18C02_P40150"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019303585.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003723 - RNA binding [Evidence IEA]; GO:0004521 - RNA
                     endonuclease activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /protein_id="WP_009873354.1"
                     /translation="MMRGDLVTIAMQGDFGKPRPALVVQANQFSEHGSVTVLPVTSTLN
                     AAPLLRVTVQPSAENGLQKPSQVMVDKAMTVLRSKVGPAFGRIDADALLEVERCLAVFL
                     GIAK"
                     /name="type II toxin-antitoxin system PemK/MazF family
                     toxin"
     gene            15850..16176
                     /locus_tag="H7R68_RS25555"
                     /old_locus_tag="WP7S18C02_P40160"
     CDS             15850..16176
                     /locus_tag="H7R68_RS25555"
                     /old_locus_tag="WP7S18C02_P40160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009873353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_009873353.1"
                     /translation="MKTIYTIPAPDSLGAMIEVYGEPENAWYEWRIIDGGRTVRDTGTE
                     GHSAFQGRQYGQAEIALRDALMFASGLPIDGDTPTDAASLEAGYAAKAKAEAARQGAGT
                     PGSA"
                     /name="hypothetical protein"
     gene            16205..17083
                     /locus_tag="H7R68_RS25560"
                     /old_locus_tag="WP7S18C02_P40170"
     CDS             16205..17083
                     /locus_tag="H7R68_RS25560"
                     /old_locus_tag="WP7S18C02_P40170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009873352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase RepA family protein"
                     /protein_id="WP_009873352.1"
                     /translation="MALDIMAAFTNEPPELDFIWPGFLAGTVGALVAPGATGKSFFALE
                     AAMSIACSVAGGDLVGLAPAHTGRVVYLAGEDPQPALVRRVHAIGQHLNQSAREAIAEN
                     LMLEPIMGKRLNVMDEAHLRRVIDYSAGARLIVLDTLSRIHSLDENSNGDMAHLVSVLE
                     HIAATTGAAVLYLHHVNKGSARDGQTDQQQAARGASALIDNARWCGYVAKMTEQEAERL
                     SDRGFDRAPIGNERRGLFVRFGVSKQNYDATPLDRWYQRHTGGVLLPVELQEIKRESGN
                     KGGKGYDSAAY"
                     /name="helicase RepA family protein"
     gene            17064..18056
                     /gene="repC"
                     /locus_tag="H7R68_RS25565"
                     /old_locus_tag="WP7S18C02_P40180"
     CDS             17064..18056
                     /gene="repC"
                     /locus_tag="H7R68_RS25565"
                     /old_locus_tag="WP7S18C02_P40180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009873351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein C, IncQ-type"
                     /protein_id="WP_009873351.1"
                     /translation="MTQQRIKPAYAKFDPAHVFDGLFVPTKGKKRGRLYVPPRRFGDSE
                     ISFQGFEQLGADDQSILLAVSAQLGIDGLMIEAKPPGEIGQQLRLALDFDNDDGRPLKT
                     KKTSLRSLLIDAGYDDPESGAALARIKESLNRMGNAQIREINHATGWDYRCNLLSSRFN
                     HKTGEIFVAVNPRLTGAVFREQHVKVSLFERNELESEAAKLLHCWLCSNIRLGRSLGNG
                     NGAHIDTLAPHVWGKAAWEEASTKVRSVRRGQLRDALDEISDRTRGLQGGMGWAIDQTS
                     SGLVLVSRPKELPFLEGEHDMRPSEYHDLMSQPPMQEPDLFDPQDWTPD"
                     /name="repC"
     gene            complement(18109..19488)
                     /locus_tag="H7R68_RS25570"
                     /old_locus_tag="WP7S18C02_P40190"
     CDS             complement(18109..19488)
                     /locus_tag="H7R68_RS25570"
                     /old_locus_tag="WP7S18C02_P40190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009873366.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-guided endonuclease TnpB family protein"
                     /protein_id="WP_009873366.1"
                     /translation="MLTGIKLRANPTSHQKLILSQWMGCARSIWNAKVEEERYYRTYAR
                     KYCTIGTYAPIDQTTSQFKSKELSPWLSECPSQILRNSAVNWYQTYQKFMSGKCGRPKR
                     KPKTDKGSIYLTREVFRFDHCDDGNVRLFIGTKTNNIGYLSFKAHGKFEIPNSLYVRKE
                     RGHYYVSFCYEQGQPDRKLSTNEEHLAFLQGATREYLEEHTMGVDRGVAIPVCAGEQTY
                     DFTHSQKKNMSKADRYIKRLQRKLARQQKGSNRRAKTKHRIAVHHAKKANIRNDFAHKT
                     SRLLVDSSAKIIVFEALRTARMTRRPKAKQDEQGRFISNKAKQKAGLNKSILNVGWHVI
                     ETYTYYKAYSSSKAVFKIPAPTTSQECAKCGHTHPDNRKTQALFVCGNCGNTDNADHNA
                     SLVIKKRAINLILDTGTVLSGDGVLRTQSDSGRGGNRKTGRAKSSTSSAQRSVKKEKLA
                     A"
                     /name="RNA-guided endonuclease TnpB family protein"
     gene            19565..20020
                     /gene="tnpA"
                     /locus_tag="H7R68_RS25575"
                     /old_locus_tag="WP7S18C02_P40200"
     CDS             19565..20020
                     /gene="tnpA"
                     /locus_tag="H7R68_RS25575"
                     /old_locus_tag="WP7S18C02_P40200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016659780.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
                     /protein_id="WP_009873365.1"
                     /translation="MYDWRTGRSCIFKNNVHLVFVTKYRRGVFTKEMLERTEAIMKETC
                     EQMDCELLEFGGEDDHIHMMVSVHPKLAISNLVSKLKGKSSYMIRREYWDRVKTMLWGN
                     HFWSPSYCVVSCGGVALDVVREYINNQNEPPSEKAMKTSQALKQRKE"
                     /name="tnpA"
     gene            complement(20043..20678)
                     /gene="tetR(C)"
                     /locus_tag="H7R68_RS25580"
                     /old_locus_tag="WP7S18C02_P40210"
     CDS             complement(20043..20678)
                     /gene="tetR(C)"
                     /locus_tag="H7R68_RS25580"
                     /old_locus_tag="WP7S18C02_P40210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009873364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetracycline resistance transcriptional repressor
                     TetR(C)"
                     /protein_id="WP_009873364.1"
                     /translation="MNKLQREAVIRTALELLNDVGMEGLTTRRLAERLGVQQPALYWHF
                     KNKRALLDALAEAMLTINHTHSTPRDDDDWRSFLKGNACSFRRALLAYRDGARIHAGTR
                     PAAPQMEKADAQLRFLCDAGFSAGDATYALMAISYFTVGAVLEQQASEADAEERGEDQL
                     TTSASTMPARLQSAMKIVYEGGPDAAFERGLALIIGGLERSACAISLL"
                     /name="tetR(C)"
     gene            20771..21961
                     /gene="tet(C)"
                     /locus_tag="H7R68_RS25585"
                     /old_locus_tag="WP7S18C02_P40220"
     ARG             20772..21958
                     /name="tet(C)"
                     /gene="tet(C)"
                     /gene_name="tetracycline efflux MFS transporter Tet(C)"
                     /tool="amrfinderplus"
                     /drug_class="TETRACYCLINE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            21865..22203
                     /locus_tag="H7R68_RS25590"
     CDS             21865..22203
                     /locus_tag="H7R68_RS25590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005291943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002310911.1"
                     /translation="MERVGMDCRRRPIPCLPPRVASRCMEPGHLDLNGSRRHLANGFTT
                     PRIGANQFLRRTVNAQTNPWQNISIASAISSSRTRRISGSVGSWPRVRMIVLLSLRTRL
                     GWRGCLTG"
                     /name="hypothetical protein"
     gene            22411..>22707
                     /locus_tag="H7R68_RS25600"
                     /old_locus_tag="WP7S18C02_P40240"
                     /pseudo=""
     CDS             22411..>22707
                     /locus_tag="H7R68_RS25600"
                     /old_locus_tag="WP7S18C02_P40240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000015958.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA];
                     GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /name="tyrosine-type recombinase/integrase"
     gene            <22917..23624
                     /locus_tag="H7R68_RS25605"
                     /old_locus_tag="WP7S18C02_P40250"
                     /pseudo=""
     CDS             <22917..23624
                     /locus_tag="H7R68_RS25605"
                     /old_locus_tag="WP7S18C02_P40250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558120.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3 family transposase"
                     /name="Tn3 family transposase"
     gene            <23769..23963
                     /locus_tag="H7R68_RS25610"
                     /old_locus_tag="WP7S18C02_P40260"
                     /pseudo=""
     CDS             <23769..23963
                     /locus_tag="H7R68_RS25610"
                     /old_locus_tag="WP7S18C02_P40260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018229750.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            24068..25660
                     /locus_tag="H7R68_RS25615"
                     /old_locus_tag="WP7S18C02_P40270"
     CDS             24068..25660
                     /locus_tag="H7R68_RS25615"
                     /old_locus_tag="WP7S18C02_P40270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008328818.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS91 family transposase"
                     /protein_id="WP_020229221.1"
                     /translation="MPATSKPKLYNPRHPERTLLYQTVAEHYETWLDLASAGQFDGQGD
                     HRSPKPYVRQAFAKYLECGIFAHGFARARCDDCGHDFLVAFSCKGRGVCPSCTTRRMAE
                     TAAHLTDHVFPRLPVRQWVLSVPKRLRYFMQRDSVVLGMVLRIFLRVIEQTLQANSPCA
                     AHANKAALHIGAVAFIHRFGSSLNEHVHFHVCVVDGMFEAVAGEASEQGTRTTAISVMF
                     HPAIGIDPEAVTQAQASLRRRILRAFVGRGLLEGFEAQEMLGYKHSGFSVDTSVCIAAQ
                     DRAGLERLLRYCARPPFALDRLRKAGSELIYRCAKQHSEPGSDRRDQRKAKRGVRADEL
                     HLTPLELIDRLAALVPPPRAHRHRYYGVLAPNSPLRAAAVALGAGQTAGAGTGTAQPEP
                     GGVTAAVDAMGVATVGGPSQPEPTQPALPKRSAHILWAVLIARIYEVLPLLCPLCGGQM
                     RIIAFITYSADLRHILEHIGVETEPPRIAPARGPPLWDGCDVPMGDGVEVEPDWGEAAQ
                     PAPDFEVDQRVSW"
                     /name="IS91 family transposase"
     gene            25717..26340
                     /locus_tag="H7R68_RS25620"
     CDS             25717..26340
                     /locus_tag="H7R68_RS25620"
                     /EC_number="3.5.1.28"
                     /inference="COORDINATES: protein motif:HMM:NF013670.3"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]; GO:0008745 - N-acetylmuramoyl-L-alanine amidase
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_182930711.1"
                     /translation="MCKPKNLGLLALIKRSGRLSLKACDAQNLGHNRPPVVGFPIRKLK
                     ELLTKKGAKVLMTREIDDSLDDHIPNNGSRHREDLNSRVKIVNNSKVDILLSIHVNHNK
                     NANKIGPIIFYNTSSEESKYFANHIQEYLNNLSSYKEIDIGTKHKATPGDYYLLRNISP
                     PGVIIEMGFISNESDRRLLLDNKHLDEIVELITKGIIDYFNADR"
                     /name="N-acetylmuramoyl-L-alanine amidase"
     gene            26734..27273
                     /locus_tag="H7R68_RS25625"
                     /old_locus_tag="WP7S18C02_P40280"
     CDS             26734..27273
                     /locus_tag="H7R68_RS25625"
                     /old_locus_tag="WP7S18C02_P40280"
                     /inference="COORDINATES: protein motif:HMM:NF012792.3"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_070085966.1"
                     /translation="MQIINMTQVNKTQLIQAAQILTDSIPIGWPTLHDAMDEIKERLIP
                     ENTLLAAIENDIVIGWGGILAPMYNGNVFELHPLAVRSDKRNLGIGRTIVTALEDEARK
                     QGGLTIHLGADDEGGDGETSFANVDLYDDLPGKINNFNAGTHQSGFYLKLGYKIIGVMP
                     DANGIGKPDIYFGKGL"
                     /name="GNAT family N-acetyltransferase"
     ARG             complement(4011..4525)
                     /name="APH(6)-Id"
                     /gene="APH(6)-Id"
                     /gene_name="APH(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.42"
                     /coverage="61.51"
     Typing          16206..17083
                     /name="IncQ2"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          12568..15236
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="99.888"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 gatctagtaa atctgctatt gtcattccaa tagctcccgc aaatccccca taccatccac
       61 ctagaagtaa agcagctaat acgccatcgg tgaggttcaa ttgccggaag tgattctggc
      121 cgttgacgcc caggtgcgct ttagctggat catgctcgga cgtgagccgc gctctaccga
      181 cgagctgctg atggtctatg ccggcatcat ggcccacggc accagtctga ctgcggtcga
      241 atgcgcgcgc atgattccgc aattgtctgc caccagcatt cgccaggcca tgcgctgggc
      301 gcgggacgaa cggcgtctga gccaggcctg ccaggctgtg ctggaattca tgcagcgaca
      361 cccgattgcc gccacctggg ggcggtccga tttggcatct tctgacatga tgagcatgga
      421 gaccaccaaa cgggtgtggc aagcccggct tgatcctcgg cgcaacacac cttccattgg
      481 aatctactcc catgtaaaag accggtgggg catcttccat gcgcagccct ttgtgctcaa
      541 tgagcgccag gcgggcgtgg ccattgaagg tgtcatccgc caagaaaagc tggagaccag
      601 ccagcttgct gtggataccc atggctacac ggggtttgag gtccaaccgt acgaaaacgt
      661 acggtaagag gaaaattatc gtctgaaaaa tcgattaggc tagaaagtcc gttaagtgcc
      721 aattttcgat taaaaagaca ccgttttgat ggcgttttcc aatgtacatt atgtttcgat
      781 atatcagaca gttacttcac taacgtacgt tttcgttcta ttggccttca gaccccatat
      841 ctaatcgata ggtgaaccat cctgcacaat tctgatgatt ttcatgaatc ctgtcgtttt
      901 taacataatg ggtattaagt gtagtgtgtt tgtaatggct caatagtaat gtccgcctgt
      961 ggctcaattc agatgtccgc gctatggtaa gcttcactgg tccgtttaaa ctaccgggag
     1021 gcatatcatg agcgcagaaa gctcaggagt gtttactttg aaagagatca accggatcaa
     1081 gattatacag gacgtcattg aacgtcgcat cacaacgcgc cgtgcggccg agcacctcgg
     1141 tatcagcgac aggcaatgcc gcagacttct tgcccgttac cgtgaaggcg gaccgcttgg
     1201 tatggccagc agacgatgtg gcatgcgtgg taaccgccag ttgccacccg ggctcgcaga
     1261 tcaggctctg gaactgatca agacgcgtta tgctgatttc ggtccgactc tggcgcgtga
     1321 aaagctcgaa gaactccacg gactgtttct tggcaaagaa actgtccggc gcatcatggt
     1381 gcgggctggc ttatgggttc cccgtaaaca acgtgccgca aggatccctc aaccacggta
     1441 ccggcgtccg tgtactggtg agctgataca aatagatggc tgtgatcacg actggtttga
     1501 aggccgtggc ccggcctgca ccgcgctggt ctatgttgat gatgcaacca gcaaactgat
     1561 ggaactgttg tttgttaaat cggagtccac gttttcttac ttcgaagcca cgcggcgcta
     1621 tatcaataag catggtaaac cgctggcact gtacagcgat aaagccggtg tttttcgtgt
     1681 taacaataaa cacgccacag gcggagacgg gcatactcag tttgggcgag ccatgcatga
     1741 actgaacatc cagactatct gtgcagaaac cagtcccgcc aaagggcgtg tagaacgagc
     1801 tcacctcact ttacaggatc gtctggtcaa agagctgcgg ttacagggca tttgttcaat
     1861 ggaggctgca aatgacttcg ctgaggccta tatggctgac tataaccgcc gttttggcaa
     1921 agtaccgcga catgattttg acgtacaccg tgctgtagaa catgatgagg acctggggct
     1981 tattttcact gttcgtgaaa aacgtaaagt ctcaaaatcg ttgacgatac aatatgataa
     2041 aatgttgtac ctgattgaag acagcgaact gagtcgccgt gcaataggta aatatatcga
     2101 tgtgtatcac tatcctgatg gcagaaaaga gctgcgcctg aacggtacgc tacttcccta
     2161 ctctacctac gaccgactgt cagaaatcga ccagggcgcg attgtcgata acaagcgtct
     2221 tggccgaacc ctggagttta tcagtctggt gcagagcaag cgggataaca cgcgctctca
     2281 gtcaattccc gctggagatg gcccttcccg acgacggcca aagcaggaag ggaagaaatc
     2341 ccagcgctca ctggataatg atgacatgct cgaagcactc aaacagcttc agtcacgttc
     2401 agaggacatt tttggtaaaa gagcccgctg atggtactca ctggccggac agtggttgct
     2461 caccagttga tattgtccgg ccagacccat gatgtattat tcatttcgtt cagcatcttt
     2521 atgtcctgct tttcacgggc atacttaccc cataatgaat gaaaagaacg aacaatactg
     2581 attaactgct tttttctttg ctccggagat aggctgataa aatagcagca cctgctgtca
     2641 atattatcct caatgaaatt aaaatcagag tctgatgcat attttactgt tagcataata
     2701 tcattcgacg ttgttctctc agactctgtt aatgctgatt ctatcaggta ttcaaaggca
     2761 tacatgacag acagctggtt tttgtctgtc tgaatataac ccattgagtt tctgagtatt
     2821 gaggactgta ccaggaccag aggccataaa agctcaacac cataaagctt atatgtatca
     2881 tgttgatcat actgatgttg ctcaacacga cgattacctt cccgtgcttt acgaatatca
     2941 taggcaaggg ataacataaa tccgtcttta actttaatca gtgggctttc atccacgatg
     3001 taatgaatga gttcatgtaa ttcattcagg gcttctgaat ctccccacag tataaaacct
     3061 gcattgttcg gcgttaactc gtatcgaagc atgggctcaa tcatcctgtt gtttcagtcg
     3121 gaggaaagtc tatcagtaaa gagaatgaga gatcaaagtg gtcattttaa ttgagctgga
     3181 taacggacat ttcaattgag ccttgacagt gtttgtctat caataagaga tttatctaat
     3241 ttaattcaag cccccggcgc aggtggtaac cacccccggc gcaggtggta accacccccg
     3301 gcgcaggtgg taaccacccc cggcgcaggt ggtaacctga caagccacaa aaacgcccgc
     3361 aaacccttgt cagtactgag ttttcgcgtt tttccaaaat tccggtctaa gaagttctaa
     3421 agaacttcta ccatgcgcgg ctttcagccg ccgctttagg cgtcgtctga agccttgcct
     3481 tcgggcttcg ccctgcgcgg gctaaagccc ttgcagacac acccccgccc ccgccccgcc
     3541 gctaccccct tccttgcagg cgaaaacgcc tctactggct ttctagggcc tctgccgggg
     3601 ctgcggtgag cgtatccagc agatcgacta tccgcctcat ggcttctaac cacgcttcgt
     3661 gcatccagaa tggggctatt tcgccgtgct ggagtgtgca aagcggattg agaacccggc
     3721 gcgggttctt ccatgtctcg acggaaagca ccagcccgtc cgcatggatg gaaaagactg
     3781 gtagcgcttt cggctggccc ttcttcttgc cttgcgtttc ggttggcttg aggtcgtccc
     3841 aaacgccttg cacggttttg ttcagttcgt cgatgaagcg ttccggcatg gttttcaaga
     3901 gttggggtcg tttgcgggag agggcgaaat cctacgctaa ggctttggcc aacgatattc
     3961 tccggtaaga ttgatgtgtt ccgaggggat aggagaagtc gcttgatatc tagtatgacg
     4021 tctgtcgcac ctgcttgatc gcggccgcga tagctagatc gcgttgctcc tcttctccat
     4081 ccgcgttcca agctgcggaa aggcacccat aagcgtacgc ctggtcgagc aggcgacgcg
     4141 gatcgacgtc cagcgcacga gagaatgcgt ccgccatctg tgcaatgcgt ctgggatcga
     4201 gacaaaggtc gtctctgtca gccggatcgt agaacatatt ggcggcgcca aagcccactt
     4261 caccgaccag accgacggga tctatcacca gccagccgcg actggagaac atgatgtttt
     4321 catgatgcag atcgccatgt agcccacgca gttccgaggc attgctcatc atttgatcgg
     4381 ctataatcgc cgcgtggacg tagtcagttt gacaacctgc gttttgatca tcgcgcgccc
     4441 gctgaaacaa agctgcaaag cgatcccgga tcgggagaag ggcagaaggc aggggttcct
     4501 cagatgcggc atacagcttc gccattagtt ccgctgcaat ttggggtcgg ttccggctga
     4561 gggcgaaatg acaccctaag cgttagctct gtgtcgttgc acgatgtcag cgacggtatt
     4621 cttgctgata ccgagctcgc gtgcgatcca gcgatagctg cgtccctcgg ccctcatcgc
     4681 aaccacctta ggcaaaagtc ggtctgattt tggtcgcact ccggcctgac gaccaagcct
     4741 cttaccacgt gccttcgcaa cagcaaggcc tgacttgacc cgctcgctga tgagatcccg
     4801 ctcaaactcc gcaatgccgg aaagaaacgt cgccagcatt cgtccatacg gcgacgaaag
     4861 atcgaacgcc attccattca tggctatcac ggaaaccttc cagttctcca gttcacgtag
     4921 cgtattgagc agatcgagcg tcgagcgccc ccaccgggaa agctcagtga ccaggattgc
     4981 atcaatttgt ctggactggg caagcgccag gactttcttt cgctcggccc ggtcgagttt
     5041 agttcctgaa cctgtttcct taaatattcc caccacgtcg tagccggcac ggccggcgaa
     5101 ggctcgcaga tcaaattcct ggcgttcaca agactgatcc gctgttgaaa cccggcagta
     5161 aatggcggca cgatgtccca attgaaccct cctggatttt tgtatcggaa cgccctgatt
     5221 tatatgggct ggctgttgtc caaaacagac tatacttcaa aagggacgaa tttgtatgtc
     5281 acgacgccat attttcaccg aacggcagcg agcagcgctg ttcgatctgc ccacggacga
     5341 actgtcgcta ctgaagttct acacgctggg cgatgatgac ctggaaaaca ttaggcagcg
     5401 ccgcagaccg gaaaacagga ttggctttgc cctgcaactt tgtgccttac gatatccggg
     5461 ccgtgcactg gctcctggtg agatgatccc gcgtgaagtc ctttccttcg tcggtgctca
     5521 gcttggagtt ccggctgatg cgcttctcac ttatgccaca cggcgccaaa cccgtcagca
     5581 gcacatggac acgctgcgcg aaatttacgg ctacaagacc ttcacgggcc gtggtgcccg
     5641 tgatctgcgg gagtggactt tcggccaggc cgaagatgcc agatcaaacg aggatcttgc
     5701 tcatcgtttt attgtgcggt gtcgggaaac ttccaccatt ctgcccgcag tatcgacaat
     5761 cgagcgcttg tgcgcggatg ctctggtcgc cgctgagcgg cggattgaaa cgcggattgc
     5821 ggaaaattta acagcggatg ttcgcgatca cctggacaaa cttctgagtg aaatgctcgc
     5881 cggcaatatc agtcgtttca tctggcttcg caacttcgag gttggtaaca actcggctgc
     5941 tgctaaccgt ttgctcgaca ggctcgaatt tctgcgtacc ctgaatatca atcatagtgc
     6001 tttggccagc atacctgccc atcgcattgc ccggctgcgt cggcagggtg aacgctactt
     6061 caccgacggt ttgcgtgaca tcacttcgga ccgccgctgg gcgatccttg ccgtctgtgt
     6121 tgtggagtgg gaagcggcga ttgctgatgc catagtcgaa acccatgaca ggatcgtagg
     6181 aaaaacctgg cgggaagcga agcgccagca tgacgaaaca atttccggct ctaaagccac
     6241 actcacggat acgatccgta ccttcaccgc gctgggagct tcgttgcttg aggcccgcag
     6301 tgacggaacc ccgctggaga tggctgtcgc cagttcggtt gcatgggacc ggctcgctca
     6361 actggtagcg acagggactc aactcagcaa cacgctagcc gatgagcctc ttgcatatgt
     6421 cgggcaggga taccatcgct ttcgtcgtta tgcgccccgc atgttgcgct gtctgaagct
     6481 cgaagccgcg ccggtcgccg gaccattggt agcagcagct ttgtcgatcg gagagatgaa
     6541 aggtgttgca tcgccagaaa ggcgtttcct gcggcccagc tccaaatgga accgtcattt
     6601 acgagctcag gaaaaaggag atacccgtct ttgggaagtg gcggtactct ttcacctccg
     6661 ggatgctttt cgttccggag atgtctggct cgctcattcg cgccgctatg gtgacctcaa
     6721 gcaggtactg gtgccgatga tcgcggcgca ggaaaatgca aaactggccg tgccttccaa
     6781 cccacaggat tggctggcag acagaaaggc gcgactcacg atcgctctta agcggctggc
     6841 ccgggctgcc cgtaacggca ctattccgca cggtagcata gaagatggaa cgttgcggat
     6901 cgacaggttg acagcagacg tgccggatgg tgccgaggca ctcatactgg atctgtatcg
     6961 ccgaatgccg tccgttcgga ttaccgacat gctgcttgaa gttgatgcag cccttggttt
     7021 cacagatgcg tttacccatc tgagaaccgg ggctccatgt cgcgaccgga tcggtctgct
     7081 caacgtcctg ctcgctgaag ggctcaatct gggcctgcgt aagatggcgg aagctacaaa
     7141 cacgcatgat tactggcagc tctcacgcct tgcccgctgg catgttgaaa gcgaagccat
     7201 gaaccaggca ttggcaattg tggtggccgc gcagggtaaa ctgccgatgt cacgcgtctg
     7261 ggggatgggc acgtcagcat cgagcgatgg tcagtttttc ccgacagcgc ggcatggcga
     7321 agccatgaac atggtcaatg ccaaatatgg ttctgttccc ggcctcaaag cgtatactca
     7381 cgtaagcgac cagttcgcgc cattcgcttg tcagtcgatc ccggcgaccg tgagcgaggc
     7441 accgtatatt ctcgatggac tactgatgaa cgaggtcggt cgccatgttc gcgaacagta
     7501 tgccgataca gcaggattca ccgaccattt gttcggagcc agtagcctgc tcggctacaa
     7561 tctcgttctg cgaatcaggg atctgccatc gaagcggttg tacgtattta atcccgatac
     7621 gacccccagg gagttacgca agttggtagg tggaaaagcc cgggaggatc ttatcgttgc
     7681 gaactggcct gatattttcc gttgtgccgc gacgatgacc gctggcaaaa tcaggcccag
     7741 ccaactcctg cgcaagctcg cttcttaccc acgacaaaac aaccttgcag ttgcgcttcg
     7801 tgaagttggt cgtattgaac ggaccctttt cattattgag tggatcctgg atacggacat
     7861 gcagcggcgt gctcagatcg gtcttaacaa gggagaggcc caccatgcgc tcaaaaatgc
     7921 gctccgtatc gggaggcagg gggaaattcg cgatcgcacg acagaggggc agcactaccg
     7981 aatcgctggg ctcaatttat tgactgcggt gatcatttac tggaataccg tccatcttgg
     8041 tcatgccgtc acggagcggc ggaacgaagg gttggatgtt ccccctgaat ttcttcccca
     8101 catatcccca ttgggctggg cgcacattct actgactggc gaatatcttt ggcccaagga
     8161 accgaaagct tagggtgtca tttcgccctc agccggaacc gacccctatt tgccatgcaa
     8221 aggtcgcaga cgaagcgggg gtggtgcgtg acaccctgaa atccttcgcc gagatcgggg
     8281 gcgccctggt cgatgcacag gatgatggcc agccgctggg cgatgtcatc gcgagtgggt
     8341 cagggtggga cggcttaaaa acccttgttg caatggcaac caggctgacc gccaccatgg
     8401 ccgacgatcc gctcaatcat gtgctcgacg gttatcaccg cttccgccga tacgctccac
     8461 gcatgttgcg cctgctcgat ctgcgagctg cgcccgttgc actgccgctt ctggaagctg
     8521 tgacggccct tcgtaccggt ttgaacgatg ccgcgatgac cagcttcttg cggcccagct
     8581 cgaaatggca tcgccacctt cgggcccaga gggctggcga cgctcgccta tgggagatcg
     8641 cggtgctgtt ccatctgcgc gatgcgttcc gctccggaga tgtctggctt actaggtccc
     8701 ggcgctatgg cgatctgaaa cacgcactcg ttccggcaca agccatcgcg gaaggcggtc
     8761 gtctcgctgt gccattgcgg ccggaggaat ggctggcaga ccggcaagct cgcctcgaca
     8821 tgcggttgcg cgagcttggc cgtgccgctc gcgcaggcac gatcccgggc gggtcgattg
     8881 agaacggcgt tctgcatatc gagaaactcg aagccgccgc gccgacaggc gccgaagatc
     8941 tggtgctcga tctctacaag cagatcccgc ccacgcgcat caccgatctc ctgctggagg
     9001 tggatgcggc gaccggcttc accgaagcgt tcacccatct gcgcacagga gcaccctgcg
     9061 ctgaccggat cgggctaatg aacgttatct tggcggaagg gatcaacctc ggcttgcgca
     9121 aaatggcgga tgcgacaaac acccacacct tctgggaatt gatccgcatt ggacggtggc
     9181 atgtcgaggg cgaagcctat gaccgggcgc tggccatggt ggtcgaggca caggcagcgt
     9241 tacccatggc ccggttctgg ggcatgggca cgtcggcttc gagcgacgga cagttcttcg
     9301 tcgctacaga gcaaggtgag gccatgaacc tggtcaacgc gaaatatggc aataccccgg
     9361 gcctgaaagc ttatagccac gtctccgacc aatatgcgcc gttcgcaacc caggtaattc
     9421 ctgcaacggc aagcgaagcg ccttacatcc tcgatggcct gctgatgaac gatgctggac
     9481 gccatatccg cgagcagttc accgacacgg gcggcttcac cgatcacgtc tttgccgcat
     9541 gtgccattct cggctaccgg ttcgctccgc gcatccgcga cctgccatcc aaacggctct
     9601 acgcgttcaa tccgtcggcc gccccggcgc acctgcgagc gttgatcggc ggaaaggtca
     9661 accaagccat gatcgagcgc aattggcccg acatcctgcg catcgccacc accattgctg
     9721 ccgggaccgt cgcgccaagc cagattctgc ggaaactcgc ctcctatccg cggcagaacg
     9781 agctcgcgac agccctgcgg gaagtcggtc gcgtcgagcg caccctgttc atgatcgact
     9841 ggattctgga tgccgaactc caacggcgtg cccagatcgg gctcaacaaa ggcgaagctc
     9901 atcatgcgct gaagcgggca atcagcttcc accgccgcgg tgaaatccgc gaccgttccg
     9961 ccgaaggcca gcattaccgc atcgccggca tgaatctgct cgccgccatc atcatcttct
    10021 ggaacaccat gaagctcggc gaggtcgttg caaaccagaa acgcgatgga aagctgctat
    10081 cgcccgatct cttggcccat gtttcgccgc tcggatggga acacatcaat ctcaccggag
    10141 aatatcgctg gccaaagcct tagcgtagga ttccgccccc tcccgcaaac gaccccgagt
    10201 tcggcagtga ttgcgttcgc gtcctcaaat tgctttcttg cttcggcttc ctttttccgt
    10261 cgtttttgcc gctcctgttc gtattcgtct aaggtttgcc tgtgtctgcg ctgtgcttca
    10321 gcttccgctt cttcagcttg ccttcgtgct tcctctttgg ctttctgtcg gtgtgcttca
    10381 ccctctgctg tgagtgctgg ttttaccagt tcgccagact tggcctcgat ggtgatcgaa
    10441 agcggttcgc cgcgatggtc taccagatcg aacggcagac catcagcatc gaaggcggtt
    10501 aggtagagat tggccccata gaccttgtgc cccggcctca cagcttcgta tttttctgct
    10561 gctgcgtgca gtgcttccgc taggcgttct gccgtgattt ctcctttgat cttgattctc
    10621 atggcaacct ccatccgtag gtgccatccg atgcgggctt gacgtagcac acgccttttt
    10681 cgacgtacca ccccggccta tcgcacttcg ccaagctggc gaggcttccc gtttgcgcga
    10741 agcggtaggc caagcgcccc tctggcgtgt tggcccatgc cgccgccgct ttctcgtcct
    10801 tggcttcggt gtatcccgcg ccgtatccgg cctgatagcc cgaatccttg ccgctgctgt
    10861 gcatgtacca gccgaacagg ccgacgcaca ggaaggccac cgcgatgcag cccgccgccc
    10921 actgccacat ctgctttgcc gatgtgttgt gcgcgacctc ttgcgctgct gctgctaccg
    10981 cttgcgccaa atccgccttg gctgcttccg ctgatgcttt cacggttgca tccgccgtta
    11041 ccttgaaatt gaccaaggta tctttggccg cttgtgctat cgcttgcggg aacttctcat
    11101 actggccttg gtagtgttgc aaggccatga gcaccagcca cagcgcatca ttgtttttca
    11161 ggccgagcgc atcccgaacc cggtaaagac tttgccgctc cgcgtcacta ggttgcctgc
    11221 cgagcagctt tgcaaagctg tcgtctaggt cactcatgga ctacggcctc caataccttt
    11281 ttggcctcgt tgcgccaccg cgtaagctcc gcacggttgc caatgggcag ttccttgagt
    11341 gctaccgcaa tgctcatgcg cttgctgtaa atgtcatcgc tcacacggtc ggccatgtcc
    11401 gggaatgtca ccgatttccc gccgcgttcc tctaccgccg tgcgcagctt ggagccgttg
    11461 taaagctcga acttcttttc ttccccgaag tgtccattgc gtaccacatg aacatccgca
    11521 ttcggaattg cgtccatgta ttcctttagc agttcgaggc tatcccgttg gcggttaatc
    11581 acccacagcg tgaccagctt gcgcttgagt tcttcaagcg tgctattcag tgtttcaccg
    11641 taggcgctca cgcccttgtt attccgtgct gccgtgttga ttaccacgac gctatccggc
    11701 ttgctatcgc acaggttcac tagctgaatc catccgtccg cctcatccag attgataagc
    11761 tccgtttccg tgctttcttt ataggctttc catacgtccg ggttagaggt gtcagactca
    11821 atcagcaaga cgctttcgcc gcgctcttgc aggtaatcaa ccgttgccat cgtaacaagc
    11881 gacttgccaa cgccgccctt gctgccaccg atcaggtaaa tgcttttcgc catgttgctt
    11941 actccttaaa tgtcgtcgct gtcaggtttc ggggtgaatg tcgccttcga tgtatccgca
    12001 ggcttcttat cggcggggag gggcgggggt gtgtctcccg gtgcttgcac cggggctttt
    12061 ttcgctggct ttgctctctg caagtagctc ttgagcgttg ctacgcatgt tcctgccaat
    12121 ccccgcctgc ccattcggcg cttcgcttct cacggtctgg ctcatcctgc aaggggcaag
    12181 ccccttgacc ccggacagtg cggcgctttc gcttcttact gtccaagaca caccccgccc
    12241 ccgcccccgg cgagaaggag acatgatgcc atttgaaacg caggggccgg aaccgctgga
    12301 cgccgttatc aatgtgcggc tgaccgcagc ggagaaggcc agattgaaag aggacgccga
    12361 ccttgccggg ttgagcatgt ccgagcttgt ccgccgccgc tacttcggca ggccgatcat
    12421 tgccaacgcc gacgccgtga tgctcaagga gctgcggcgc atcggtggat tgctgaagca
    12481 catccacaac gagagcggag gcgtttacag caaggaaaca gccggggcgc ttgttgcgct
    12541 caaggactac ttcaggaagc taaacgatga tcgttaagaa ggttccgaat ccgaagaagt
    12601 ccgcgagcaa ggcgcagcgc atcggccagc ttaccagcta tgtccgttcg ccggagtcgg
    12661 agagtccgca ggaaaagtgt ctgtatgccg gggcgcgggg tttcatgatg gacgacccca
    12721 agagccagac ggcagagatg attgcactct cacaagaagc cgtgcgcagc aaggacacca
    12781 tcaatcacta cgtcttgagt tggcgcgaag gcgaacagcc aagcccggag caagtagagg
    12841 aagcggttag catcttcatg gatgagcttg ggtggaaaga ccaccaagcc atctatggcc
    12901 ttcattccga cacggacaat atccacctgc acatcgtcat caatcgggtg catcccgaaa
    12961 cgctcaagat tgttgagaag aaccgtggat ttgatattga actggcacac aaagccattg
    13021 cacggattga gcacgcccaa ggctggcagc gtgagcaaaa cgggcgctat caggtgttgg
    13081 agaacgggga gctaggccga gcgccatacg acccggaaaa gccacgccag cccgaccaga
    13141 agaagcggga catggagaac cgcaccgggg agaagtcagc ccaccgcatc gccatcgagg
    13201 acggcgcagc catcatcaag caggcgcaga cgtgggagca gttgcaccgc gagttagcag
    13261 ccaaggggat gcgctacgaa aagaccggca gcggggcgac cgtgtttgtc ggggatgttg
    13321 gcgtgaaggc cagcgatgta gaccgcaacg ccagccttgc caagatgcag aagcggctag
    13381 gtgaatacca gccagcgccg cagcgtcagc aggtagcgcc gcgcgagccg gagccgatca
    13441 agccagacgt gccgggatgg aaggactaca tcagcgggcg caaggcacac tacgccgaga
    13501 agaacgcgga caagctggca caggacaagc ggcaggagca ggagcgcaag caacttgccg
    13561 agcagcagaa ggcccgccgc gatgaactca tgcgcggaaa ctggaaaggc aagggcgaag
    13621 tgctcaacgc catgcgcagc gtgattgccg ccgagcaggc cgcagagaaa gcggccttga
    13681 aggagaagca ccagaaggag cgcgagcagc accggcagcg gttccgaccc tatcccgacc
    13741 tggagcagtg gcagcggatg cagaaaagcc cggagcttgc cgagcagtgg cgacaccggg
    13801 ccagcgagcc gcagcgcatc gagggcgacc gcagcgagcc gccgacgccg cgagacattc
    13861 gcgcctatca gcctgaaatc gtgggccagc aggtgcatta cagccggaag gaagaagcgg
    13921 ggcggggcgg gggtgtgtct ttcgtggaca agggcaaaag catcgatatt cacgactggc
    13981 gcaaccggga cagcacgctt gccgcgttac agctatcggc gcagaagtgg ggcagcttca
    14041 ccgtgatggg gaacgacgaa tacaaggcca tgtgcgggaa gttagcagca gagcacggct
    14101 tcaagatcac aaatccagag cttcaggaga gcatccagca ggagcggcag cggatacagc
    14161 aggaaagggt gcaggcgatg aaatcggagc agctaaagca gttcgagcgg tacgcggaag
    14221 cggtaggcgc agagcgttac cgggtaacgt ctatcaagat gcgcgaggac ggcagcaagc
    14281 aaaccttcat cctcgacaag aaggacggca tcacgcgggg cttcacaccg caggagatcg
    14341 agcagcgcac gccggagatg cagcgcctac agcgccgggg cgaaaacctc tactacacgc
    14401 cgctatcgga caagaagcat cacatcctca tcgacgacat gaaccgggag aagctggagc
    14461 ggcttatccg cgacggctac cagcccgccg ccgtgcttga atccagcccc ggcaactatc
    14521 aggccatcat caccgtgccg aagctgggga cggcccacga taaggacgtg ggcaaccggc
    14581 tgagcgatgc cctgaaccgt gaatacggcg acccgaagct atcgggagcc atccacccgc
    14641 accgtgcacc cggctacgag aaccgcaagc ccaagcacca gcgggaggac ggcagctatc
    14701 ccgaggtgcg cttgctcaag gccgagcgcc gggagtgcat caaggcgctg gccttgtcca
    14761 gccagatcga cgccgagtat cagcggcaag cggccttgaa ggcgcagcag cccgagcgca
    14821 gcaaagccaa gcccgccttg gagcttgcag cggccagcgg cagcgcgatc gacgcctacc
    14881 agcggcatta tcgcgacgtg ctcaagcggc agcgtggcgg cgaggtggac ttgtcccgct
    14941 tggattccat gattgccgtg cgtatgcgcg tcaccggcca cgatcaagcc gccatcgagg
    15001 gcgctatccg ccagtgcgcc ccggccaccc ggcagaagga cgagggccgc gactggaacg
    15061 actacgcgca gcgcaccgcc cgctatgcct acagcgccgc aggcgaccgc caagccgccg
    15121 agcttgggaa gtaccgccag cagtgggaga agctggaagg gcgcgagcct gtacgccagc
    15181 aggagcaggc caaggcgcag aagatcgagc gcgataactc gccggggatg agtctttaaa
    15241 tacctgttgc atgtaacttg cgaggtgcgt acaatgttgc atgtaactta attggaggct
    15301 tggaaatggc aacagcacac gttaatcagc gggttcagaa gcatcgcgat gcattacgca
    15361 tggcggggct tcgtccggtt caaatctggg tgccggatac gcgccgcccc gacttcgcgg
    15421 aggagtgccg ccgccaatgc ctgcttgtgg ctcaggccga cagcgccgac accgccatgc
    15481 agcagttcat ggatgaagcc ttggcagacg tggacggctg gacggaatga tgcgcggcga
    15541 ccttgtgacc atcgccatgc agggcgactt tggcaagcca cggcctgcgc ttgtggttca
    15601 ggccaaccag ttcagcgagc acggcagcgt taccgtgctg cctgtcacca gcacacttaa
    15661 tgccgcgccg ttgctgcgcg tcacggttca gccgagcgca gagaacggtt tgcagaagcc
    15721 atcgcaggtg atggtcgaca aggcgatgac ggtgctgcgc agcaaggtag ggccagcttt
    15781 cgggcgcatc gacgcggacg cactgcttga ggttgagcgt tgcttggccg tgttcttggg
    15841 gattgcgaaa tgaaaacgat ctacaccatt cccgccccgg attccttggg cgcgatgatc
    15901 gaggtctacg gcgagccgga aaacgcttgg tacgagtggc gcatcatcga cggcgggcgc
    15961 accgtgcggg acaccggcac ggaaggccac agcgcctttc agggacgcca gtacgggcaa
    16021 gcagagattg ccctacgtga tgcgctcatg ttcgcttctg gcctgcccat cgacggcgac
    16081 acgccgaccg atgccgccag tctggaagcg ggctatgccg ccaaggcgaa ggcagaagcg
    16141 gcgcggcagg gtgcgggaac acccggcagc gcctaaccat aaccgttcta cacaggagaa
    16201 cagcatggct ttagacatta tggcggcctt caccaatgag ccgccagaac ttgatttcat
    16261 ctggcccgga ttcttggccg gaaccgtggg cgcacttgtt gcacctggcg caactggcaa
    16321 gagctttttt gctcttgaag cggccatgtc aatcgcttgc agtgtggcag gcggcgacct
    16381 tgtaggactg gccccggcgc acaccgggcg cgtggtctat ctcgctggcg aagatccaca
    16441 gcccgccctt gtgcggcgtg tccacgccat cggccagcac ctcaaccagt cggcccgcga
    16501 agccatcgct gagaacctga tgcttgagcc gatcatgggc aagcggttga acgtgatgga
    16561 cgaggcgcac ttgcgccgcg tcatcgacta cagcgcaggg gcgcggctga ttgtgctgga
    16621 cacattgagc cgcattcaca gcctcgacga gaacagcaac ggcgacatgg cccaccttgt
    16681 ttccgtgttg gaacacatcg cggcaaccac cggggcggct gtcctgtacc tgcaccacgt
    16741 caacaagggc agcgcccgcg acggccagac cgaccagcag caggcagcgc ggggcgcgtc
    16801 tgccctgatc gacaacgcca gatggtgcgg ctatgtcgcc aagatgacgg agcaggaagc
    16861 cgagcgcctg agcgaccggg gctttgatcg tgcgcccatc ggcaacgagc ggcgcggcct
    16921 ttttgtccgc tttggcgtga gtaagcagaa ctacgacgcg accccgctag accgctggta
    16981 tcagcgacac accggcgggg tgttgctgcc ggtagagcta caggagatca agcgtgagag
    17041 cggcaacaag gggggcaagg gctatgactc agcagcgtat taaaccggcc tatgccaaat
    17101 tcgatcccgc tcatgtgttt gacgggcttt tcgtccccac gaaggggaag aagcgcgggc
    17161 gactgtatgt gccgccgcgc cgcttcggcg atagtgaaat cagctttcaa gggttcgagc
    17221 agcttggagc tgatgaccaa tcaatcttgc ttgcagtaag cgcccagctt ggcattgacg
    17281 gcttgatgat cgaggcaaaa ccacccggcg aaataggcca gcaattgcgc cttgctttgg
    17341 actttgacaa cgatgatgga aggccgctga aaaccaagaa aaccagtttg cgcagcctgc
    17401 tgattgatgc tggatatgac gacccagaaa gcggggcggc acttgccaga atcaaggaaa
    17461 gcctgaaccg aatgggtaac gcgcagatac gggaaatcaa tcacgctacc ggctgggatt
    17521 accgctgcaa tctcctttcg agtcggttca atcacaagac tggggaaatc tttgttgccg
    17581 tcaatccgcg cctgaccggg gcggtttttc gagagcaaca cgtcaaggtt tcgcttttcg
    17641 agcgcaacga gctggagagt gaagccgcca agctgctgca ctgttggctg tgctcaaaca
    17701 tccggcttgg ccgttcgctt ggcaatggca acggggcgca catcgacacg ctagcgcccc
    17761 acgtatgggg caaggcggcg tgggaagaag catcaacgaa ggttcgatca gtcaggcggg
    17821 gtcaactacg cgatgcttta gacgaaatct cagaccgcac acgcggactg caaggcggta
    17881 tgggatgggc catcgaccag accagcagcg ggcttgtgct ggtaagtcgt cccaaggaac
    17941 tgccgttcct tgagggtgag cacgacatgc gccccagcga ataccacgac ctcatgagcc
    18001 agccgccaat gcaagaacca gatttgttcg acccgcagga ctggacgccg gactgagccg
    18061 cacctggtga actactcgct gctaaagcgg tcgagcttcc aaactaacct aagcggccag
    18121 cttttctttt ttgacgcttc gttgagcact gctggttgag cttttggctc ggccagtctt
    18181 acgattgcct ccacgtccac tatccgactg agttcgcaga accccatcgc cagataacac
    18241 cgttccagtg tccaaaatta agttaattgc ccgcttcttg ataaccagtg atgcattgtg
    18301 atctgcattg tcagtatttc cacaattacc gcaaacaaac agggcttgtg ttttgcgatt
    18361 gtcgggatga gtgtgaccgc attttgcgca ctcctgactg gttgttggtg cgggtatttt
    18421 aaataccgct ttgctggatg aataagcctt gtagtaggtg taagtctcga tcacatgcca
    18481 gcccacatta agaatagact tattcagtcc tgctttctgc ttggctttat ttgatatgaa
    18541 tcgaccttgt tcatcctgtt ttgctttcgg ccttctcgtc atccttgcgg ttcgtaacgc
    18601 ctcaaacaca atgattttgg cgctgctatc aaccaataac cgactggtct tatgcgcaaa
    18661 atcatttcgt atgttagcct ttttagcatg atgaaccgca attcgatgct tggtcttggc
    18721 tctgcggtta gagccttttt gctgccttgc cagtttgcgc tgcaatcgct tgatatagcg
    18781 gtctgctttg ctcatgttct ttttctggct atgggtgaaa tcataggttt gttcgccagc
    18841 acaaacgggg atcgccacgc ctcggtcaac acccatggtg tgctcttcca gatattctct
    18901 ggtcgcccct tgcagaaaag ctaagtgctc ttcattggta cttagtttgc gatcaggctg
    18961 tccttgctca tagcagaatg acacataata gtggccgcgc tcttttctca cataaagcga
    19021 gtttgggatc tcaaatttgc catgtgcctt aaaggacaga taaccgatat tgttggtctt
    19081 tgtcccaata aacaggcgca cgttgccgtc atcgcaatgg tcgaaacgga acacttcacg
    19141 ggtaagataa atgcttcctt tgtccgtttt aggttttcgc tttggcctgc cgcatttccc
    19201 gctcatgaat ttctgataag tttgatacca gttaaccgcg ctattacgca agatttgact
    19261 agggcattca cttagccacg gagaaagctc tttggatttg aattgtgaag tggtctggtc
    19321 gatgggcgcg taagttccga tggtgcaata tttacgggca taggttcggt aataacgctc
    19381 ttcttctacc ttggcattcc agatactacg agcgcacccc atccactgac tcaagatcag
    19441 tttttggtga gatgtcgggt tagcgcgtag cttgatgcca gttaacatga tgtccgttta
    19501 tttgctattt acacctgaaa ttattacact tacttaaact ttgtcaatct agcatgtggt
    19561 tataatgtac gattggagaa caggtagaag ctgcattttt aaaaacaacg ttcatctagt
    19621 ctttgttaca aagtatcgtc gtggtgtttt taccaaagaa atgcttgaac ggactgaggc
    19681 aataatgaaa gagacttgtg agcagatgga ttgtgagcta ctggagtttg gtggagagga
    19741 cgatcacatc catatgatgg tgtccgtaca tccaaaattg gcaatctcaa atttagtcag
    19801 caagttaaaa ggtaaatcgt cttacatgat ccggcgagag tattgggaca gggtaaaaac
    19861 aatgctttgg ggcaaccatt tctggtcgcc aagctactgt gtggtttctt gcggaggggt
    19921 tgccctcgat gttgttcggg agtacatcaa caaccagaac gaaccgccca gcgaaaaagc
    19981 catgaagaca tcacaagcgt tgaagcaaag aaaagagtag aaaccacttg cttgactcgc
    20041 ccctaaagga gcgagattgc gcaagcactc cgttcaagac cgccgatgat gagagccagg
    20101 cctcgctcga atgccgcgtc cggaccgcct tcgtagacga ttttcatcgc gctctgtagg
    20161 cgcgccggca tcgtagacgc tgaggtggtc aactgatctt cgccccgctc ctcggcgtct
    20221 gcctcgctag cttgctgctc aagaacagcg ccgacggtga agtagctgat tgccatcaac
    20281 gcataggtcg cgtcacctgc cgaaaagcca gcatcgcaaa ggaagcgaag ctgcgcgtcg
    20341 gctttttcca tctgcggcgc ggctggccgc gtcccggcat gaatacgcgc gccatcgcga
    20401 taagcgagca acgcccgtcg aaaactgcat gcattgccct tcaggaacga acgccagtcg
    20461 tcgtcatccc ttggcgtcga atgcgtgtga tttatcgtca gcatggcttc ggcaagtgcg
    20521 tcgagcaacg cacgcttgtt cttgaaatgc cagtagagcg ctggctgttg caccccgagg
    20581 cgctcagcca gtcggcgcgt cgttagacct tccatgccca cgtcgttaag cagttcgagc
    20641 gcggttcgga tcacggcctc gcgttggagc ttgttcattc gcgaattctc atgtttgaca
    20701 gcttatcatc gataagcttt aatgcggtag tttatcacag ttaaattgct aacgcagtca
    20761 ggcaccgtgt atgaaatcta acaatgcgct catcgtcatc ctcggcaccg tcaccctgga
    20821 tgctgtaggc ataggcttgg ttatgccggt actgccgggc ctcttgcggg atatcgtcca
    20881 ttccgacagc atcgccagtc actatggcgt gctgctagcg ctatatgcgt tgatgcaatt
    20941 tctatgcgca cccgttctcg gagcactgtc cgaccgcttt ggccgccgcc cagtcctgct
    21001 cgcttcgcta cttggagcca ctatcgacta cgcgatcatg gcgaccacac ccgtcctgtg
    21061 gatcctctac gccggacgca tcgtggccgg catcaccggc gccacaggtg cggttgctgg
    21121 cgcctatatc gccgacatca ccgatgggga agatcgggct cgccacttcg ggctcatgag
    21181 cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc gggggactgt tgggcgccat
    21241 ctccttgcat gcaccattcc ttgcggcggc ggtgctcaac ggcctcaacc tactactggg
    21301 ctgcttccta atgcaggagt cgcataaggg agagcgtcga ccgatgccct tgagagcctt
    21361 caacccagtc agctccttcc ggtgggcgcg gggcatgact atcgtcgccg cacttatgac
    21421 tgtcttcttt atcatgcaac tcgtaggaca ggtgccggca gcgctctggg tcattttcgg
    21481 cgaggaccgc tttcgctgga gcgcgacgat gatcggcctg tcgcttgcgg tattcggaat
    21541 cttgcacgcc ctcgctcaag ccttcgtcac tggtcccgcc accaaacgtt tcggcgagaa
    21601 gcaggccatt atcgccggca tggcggccga cgcgctgggc tacgtcttgc tggcgttcgc
    21661 gacgcgaggc tggatggcct tccccattat gattcttctc gcttccggcg gcatcgggat
    21721 gcccgcgttg caggccatgc tgtccaggca ggtagatgac gaccatcagg gacagcttca
    21781 aggatcgctc gcggctctta ccagcctaac ttcgatcatt ggaccgctga tcttcacggc
    21841 gatttatgcc gcctcggcga gcacatggaa cgggttggca tggattgtag gcgccgccct
    21901 ataccttgtc tgcctccccg cgttgcgtcg cggtgcatgg agccgggcca cctcgacctg
    21961 aatggaagcc ggcggcacct cgctaacgga ttcaccactc caagaattgg agccaatcaa
    22021 ttcttgcgga gaactgtgaa tgcgcaaacc aacccttggc agaacatatc catcgcgtcc
    22081 gccatctcca gcagccgcac gcggcgcatc tcgggcagcg ttgggtcctg gccacgggtg
    22141 cgcatgatcg tgctcctgtc gttgaggacc cggctaggct ggcggggttg ccttactggt
    22201 tagcagaatg aatcaccgat acgcgagcga acgtgaagcg actgctgctg caaaacgtct
    22261 gcgacctgag caacaacatg aatggtcttc ggtttccgtg tttcgtaaag tctggaaacg
    22321 cggaagtccc ctacgtgctg ctgaagttgc ccgcaacaga gagtggaacc aaccggtgat
    22381 accacgatac tatgactgag agtcaacgcc atgagcggcc tcatttctta ttctgagtta
    22441 caacagtccg caccgctgcc ggtagctatt gactatccgg ctgcactagc cctgcgtcag
    22501 atggctctga tccaaggcaa actgccaaaa tatctgctgg caccggaagt cagcgccctg
    22561 caccattatg ttccggatct gcatcgcagg atgctgctgg ctaccctgtg gaacacctac
    22621 atctgtatta acgaagcgct ggcattgacc ctgagtgatt tttctctggt gccgccctat
    22681 ccctttgtgc agcttgccac gctcaaaggg gtttgaggtc caaccgtacg aaaacgtacg
    22741 gtaagaggaa aattatcgtc tgaaaaatcg attagtagac aagaaagtcc gttaagtgcc
    22801 aattttcgat taaaaagaca ccgttttgat ggcgttttcc aatgtacatt atgtttcgat
    22861 atatcagaca gttacttcac taacgtacgt tttcgttcta ttggccttca gacccctaca
    22921 ccgactttgc catgtcacat gcccgtttgc ttggttttga tctttgcccg cggttgaagg
    22981 aactcaaaca gcgccacctc tttgtgccac gcggcaccaa agtgcccgca gaaatcgctg
    23041 cggtgtgcga agccaatgtc gacgtcgctt tgatcgaaaa gcattgggat agtctggtgc
    23101 acctggcagc ctcggtcatg agcggacatg ccagtgcggt ggcagctctt gcgcggttcg
    23161 gttctgccgc ccagggcgat ccaatctatg aggctggcgt gcaattgggg cggttgctgc
    23221 gtacggcgtt tttggctgac tactttgtca aggacgcttt caggaacgag ttgcgccggg
    23281 tgctcaatcg gggcgaggct gttaacgccc tcaagcgcgc catttatacc ggccggatca
    23341 gcccggcgca ggccaaacgt gtcgatgaaa tgcaggctgt ggccgatgcg ttgagcctga
    23401 tggccaacat cgtgatggcg tggaatacct cacagatgca ggcggtcctg gatcgctggt
    23461 cgaaccgccg ccaggtcatt ccaccggaac tgatcgggaa gattgcgccc accaggctgg
    23521 agagcatcaa cttgcggggt gtgtttcgct tcccggttga ccgctatgct gaccaaatcc
    23581 tgccttcgcg gccaaatgca tcgataactg gcaccaatgg atgaaaccga ccacggtttg
    23641 acgccacgaa tcgcagattt gaaagtgaac aggaaagtca atgaaatcaa cgatctacca
    23701 acaccacctc cgcgccagtg ctagcttttc gtaccgtcac ttattgcact gaaaacgagg
    23761 agaccccggg caagaacacc aatgtgtacc tgggctcagc cgaactctcg gccatctgct
    23821 ccaagctggg ccgtattccc agcaaggaag aatatctggc cgacgtgggc gtcattaacc
    23881 agagcagcga caagatctac cagtacctga acttcgacca gatcgaagaa tatgtggaga
    23941 acgccaagga agcgactgcc tgagcggcga tggctccctg aaacaacaaa cggcccttcg
    24001 gggccgtttt gctgcgtagc ctggctgagg agaagtctgc agaatgctgt gtatttacac
    24061 agtatttatg ccagccacct ccaagcccaa gctctacaac ccgcgccacc ccgagcgcac
    24121 gctgctctac caaacggtgg ccgagcatta cgagacctgg cttgatctgg ccagcgccgg
    24181 ccagttcgac ggccagggcg accaccgcag ccccaagccc tatgtgcgcc aagcgtttgc
    24241 caagtacctg gaatgcggca tctttgccca cggctttgcc cgtgcccgct gcgacgactg
    24301 cggacacgac tttctggtgg ccttttcctg caaaggccgg ggcgtctgcc cctcgtgcac
    24361 cacgcggcgc atggccgaga cagcggcaca cctcaccgac cacgtcttcc cccgcctgcc
    24421 agtgcgccag tgggtgctgt cggttcccaa gcggctgcgc tactttatgc aacgcgacag
    24481 cgtggtgctg ggcatggtgt tgcgcatctt cttgcgcgtc attgagcaaa ccctgcaagc
    24541 caacagccca tgcgcagcgc atgcgaacaa ggccgccctg cacatcggtg cagtcgcctt
    24601 cattcaccgc tttggctcca gcctgaacga gcatgtgcat ttccatgtgt gcgtggtcga
    24661 tggcatgttt gaggcggtgg caggggaggc gagtgagcag ggcacccgca ccacagcgat
    24721 cagcgtcatg tttcacccgg ctatcggcat cgaccccgaa gcggtgaccc aagcccaggc
    24781 cagtttgcgt cggcgcatcc tgcgcgcctt tgtgggccgg ggcctgctcg aaggcttcga
    24841 ggcccaggag atgctggggt acaaacacag tgggttttcg gtagacacca gcgtgtgcat
    24901 agcagcacaa gaccgagcgg gcctggagcg cctgctgcgc tactgcgcac ggcccccgtt
    24961 tgcgctggat aggctgcgca aagcgggcag tgagctcatt taccgctgcg ccaagcagca
    25021 cagcgagcct ggcagtgacc ggcgcgacca acgcaaggca aagcgaggtg ttcgggccga
    25081 cgaactgcac ctcacgccgc tcgaactcat cgaccgcctt gccgcgctgg tgccgccacc
    25141 gcgtgcgcac cgccaccggt actacggcgt gctggcgccc aattcacccc tgcgggctgc
    25201 ggcggttgca ctgggcgcag gccaaaccgc aggcgcgggc acgggcacgg cacagcccga
    25261 gccaggcggt gtgaccgcag cggtggatgc catgggagtg gccacggtcg gtggtcccag
    25321 ccagcccgag cccacccagc cagctctgcc caaacgctca gctcacattc tgtgggcggt
    25381 gctgatcgcc cgcatctacg aggtgttgcc gctgttgtgc ccgctctgcg gtggccagat
    25441 gcgcatcatc gctttcatca cctacagtgc cgacctccgg cacatcctgg agcacatcgg
    25501 ggtggagaca gagccgcctc gcatcgcgcc agcacgcggg ccgccgctgt gggatgggtg
    25561 cgatgtgccg atgggcgatg gtgtcgaggt tgagccagat tggggcgagg cggcccaacc
    25621 ggcgccggac tttgaggtcg atcagcgcgt cagttggtaa gggaaggcag cagcggtttg
    25681 gccgcgcggc agggctgcgt ctgtcactgc caaaaaatgt gcaaaccgaa aaatctcggg
    25741 ctactggcgc tgatcaagcg ctcaggcagg ctcagcctga aggcctgtga tgcccaaaac
    25801 ctgggccata atcgtcctcc tgtggttgga tttcctatcc gcaagcttaa agagttactg
    25861 acgaagaaag gtgcaaaagt attaatgacc cgtgaaatag atgattcact agatgatcat
    25921 ataccgaata atggaagccg tcatcgtgaa gatttaaatt caagagtaaa gattgttaat
    25981 aacagtaaag tagatatctt gttaagtatt catgtaaacc ataataaaaa tgcaaataaa
    26041 ataggaccta taatctttta caatacaagt agtgaagaaa gcaagtattt tgcaaatcat
    26101 atacaagagt atttaaataa tctttcgtca tataaggaaa tagatatagg gactaagcat
    26161 aaagcaacac caggagacta ttatcttttg cgaaatatct caccaccagg agtaattatt
    26221 gaaatggggt ttatctcaaa tgaaagtgat aggaggcttc tattggataa taaacatcta
    26281 gatgaaattg tagaactaat cacaaagggt attatcgatt actttaatgc agatcgttaa
    26341 taacacttaa aaagaaattc acagaatgtt ttctgctaac aacattaaaa ttgctagatg
    26401 cttacagtaa attcgataat cagcctgtac aagaagtgat ttaatgccat gttcatcaat
    26461 attcttataa aacaatttat gcaaataaag gatgtttttc tccgtaattt ctttattccc
    26521 aaggaaagta aacatataat catataagaa tctattttct tgaagtatta tttattaatt
    26581 gttataatca actcaacgag attaaattga tgcgaggtga aaaacgatgt tctacatcag
    26641 atatccttgt taatttgcga ttaaggcaaa ggcacgaagt cctccaggtt aatttgatta
    26701 catgtctaaa attaaaaaaa tggaggaatt taaatgcaaa ttataaatat gactcaagta
    26761 aataaaacac aactaatcca agcagcccaa atattgactg atagtattcc aattggttgg
    26821 ccaacacttc atgacgctat ggatgaaata aaggagcgct tgattccaga aaacacatta
    26881 cttgctgcta ttgaaaatga tattgtaatc ggttggggcg gtatacttgc acccatgtat
    26941 aatggaaatg tattcgaact acatccgtta gctgttcgca gtgacaagcg aaatctaggt
    27001 attgggagga caatcgtaac agctcttgag gatgaagcaa gaaagcaagg tggcttgaca
    27061 atacatttgg gtgctgacga tgaaggaggc gatggggaaa catcttttgc aaatgttgat
    27121 ttgtatgatg atttaccagg aaaaataaac aacttcaatg ccggcactca tcaatctgga
    27181 ttctacttaa agctcggata taagattatc ggagttatgc ctgacgcaaa cggaatagga
    27241 aaaccggata tttatttcgg caaaggatta taaaaaggat agaattgtat attccattag
    27301 taagagttaa ggatatctaa acttgtaaag ggcaagttag atttctagct atgacaaata
    27361 aataagtatt taaaagtaaa cagcttaaag gattgagttt catcctttaa gctgttatta
    27421 ttaaaactct gttttctata gattttctat aaaaatttaa ttatcctctt tattttcgat
    27481 tagtaaaaat cctgactttt tcaaagggga tattatagaa ttataaataa gactaactaa
    27541 tattacagat actacagcat ttataaatgt agttactgca cttaactttg ctagtattga
    27601 tgctagttct tgtggttgcc ctagaatata tagtttgtaa aagtatccta caataggatc
    27661 aaaaataaca ttaaaagtta atccacatat tgaagaaata agaacccatt taaatacata
    27721 acccttatta ttgctatggt ttattttagc aaaattatga gcaactaacc ctgttattaa
    27781 gccaatacat agttttaata caaatgtctt cggtgctaca gtaatgtata cag
//
