LOCUS       NZ_AP019554             7872 bp    DNA     circular CON 05-JAN-2024
DEFINITION  Klebsiella pneumoniae strain TUM17816 plasmid pMTY17816_OXA48,
            complete sequence.
ACCESSION   NZ_AP019554
VERSION     NZ_AP019554.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMD00154120
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1
  AUTHORS   Honda,N., Aoki,K., Matsuda,N., Nishiyama,N., Tateoka,T., To,M.,
            Matsushima,H., Ishii,Y. and Haruki,K.
  TITLE     Isolation of four species of highly antibiotic-resistant bacteria
            from a Vietnamese medical tourist
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7872)
  AUTHORS   Honda,N., Aoki,K., Matsuda,N., Nishiyama,N., Tateoka,T., To,M.,
            Matsushima,H., Ishii,Y. and Haruki,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2019) Contact:Kotaro Aoki Toho University; 5-21-16
            Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method              :: SPAdes v. 3.11
            Genome Coverage              :: 11x
            Sequencing Technology        :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI RefSeq
            Annotation Date              :: 01/05/2024 04:07:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision :: 6.6
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                :: 9
            CDSs (total)                 :: 9
            Genes (coding)               :: 9
            CDSs (with protein)          :: 9
            Genes (RNA)                  :: 0
            tRNAs                        :: 0
            ncRNAs                       :: 0
            Pseudo Genes (total)         :: 0
            CDSs (without protein)       :: 0
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP019554.1.
            Annotated at DFAST https://dfast.nig.ac.jp/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..7872
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="TUM17816"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pMTY17816_OXA48"
                     /geo_loc_name="Japan"
                     /note="Sputum"
     gene            1..915
                     /locus_tag="EL400_RS00005"
     CDS             1..915
                     /locus_tag="EL400_RS00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001738986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_001271348.1"
                     /translation="MSAALQYFDENLPHRPYHTDDLAFGLRISGKGRALLARYIQQNQP
                     HAQFWLVFDVDREGAAIDWSDRNAPAPNITVKNPVNGHAHLLYALNIAVRTAPDASVKA
                     LKYAAAVERSLCEKLCADVNYSGLICKNPFHLEWLVMEWREEAYTLDELADYLDLSASE
                     RRSIDKHYGMGRNCHLFEMTRKWAYRAIRQGWPAFSQWLEAVIQRVEMYNASLPVPLSL
                     AECRAIGKSIAKYTHRNFTPETFAQYVADTHTPEIQAARGRKGGSKSKRSTVATSARTL
                     KPWEALGISRAWYYQLKKRGLVE"
                     /name="replication initiation protein"
     gene            complement(1119..1517)
                     /locus_tag="EL400_RS00010"
     CDS             complement(1119..1517)
                     /locus_tag="EL400_RS00010"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001222914.1"
                     /translation="MRISNIEWLKKRIGFIRKLGEQTARQRQIIDLIDNEAGLTEQERK
                     LLHVLATAEKNDLQAQESERKQAVQKRIEGKKQRRERNHRLFLAAGLLIEAGLVDTKTG
                     ELCYKKDRILQALKELKYDLETSPNPDA"
                     /name="hypothetical protein"
     gene            1694..2620
                     /locus_tag="EL400_RS00015"
     CDS             1694..2620
                     /locus_tag="EL400_RS00015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobA/MobL family protein"
                     /protein_id="WP_001331297.1"
                     /translation="MATYHLSVKFGGKGQAANHADYIERKEKYRDRQDLEYSAHGNMPE
                     WARDNPSHFWQAADQFERANGSTYRELEIALPRELTPEQRLELVQDFVRQEAGERHAWS
                     FAIHNPKASIDGGEQPHAHIMMSQRVNDGIERTPEQYFRRYNARYPERGGAKKDSGSLT
                     LTQQKEQLRELRKRWEVKHNEHMRKHGFERGFIDCRTLKEQGIERRPEVHLGFEAAGRL
                     DDAQRHDIMQKRSEPDYSRHLEQARTVGHDIREWLDTPVKQHELVRRLQHDVAREHGFD
                     MRDRVSRQNRTAPERVKSPSRGFSMGF"
                     /name="MobA/MobL family protein"
     gene            2623..3156
                     /locus_tag="EL400_RS00020"
     CDS             2623..3156
                     /locus_tag="EL400_RS00020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000168770.1"
                     /translation="MASTEEKLLTLLLSVEHLQHTAMEQQKAVADSLAVARETLRGYRD
                     ISDGVAKQVRDEVRNEVQKLDVAGLIGERISQDFQRLEESVANMKANADALNRDIATIH
                     SNIVQEYNTLKGYSWKWLGGVSVAFLVMFCVLGWGMKTILDRNYNATAAVYQKVVTLED
                     KLVEKPVTGKSRKN"
                     /name="hypothetical protein"
     gene            complement(3222..3422)
                     /locus_tag="EL400_RS00045"
     CDS             complement(3222..3422)
                     /locus_tag="EL400_RS00045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001618649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_126449488.1"
                     /translation="MSKLESLPIDATVDFMASSQAFREYLKKLPPDNTIPPALTDEHVP
                     LYIRRLEYYRLLYRPKQTESY"
                     /name="hypothetical protein"
     gene            complement(3415..4112)
                     /locus_tag="EL400_RS00025"
     CDS             complement(join(3415..3863,3863..4112))
                     /locus_tag="EL400_RS00025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558267.1"
                     /ribosomal_slippage=""
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1 family transposase"
                     /protein_id="WP_223433957.1"
                     /translation="MASVSISCPSCSATEGVVRNGKSTAGHQRYLCSHCRKTWQLQFTY
                     TASQPGTHQKIIDMAMNGVGCRASARIMGVGLNTILRHFKKLRPQSVTSRIQPGSDVIV
                     CAEMDEQWGYVGAKSRQRWLFYAYDRIRRTVVAHVFGERTLSTLERLLGLLSAFEVVVW
                     MTDGWPLYESRLKGELHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVI
                     GHYLNIKHYQ"
                     /name="IS1 family transposase"
     gene            complement(4367..5164)
                     /locus_tag="EL400_RS00030"
     CDS             complement(4367..5164)
                     /locus_tag="EL400_RS00030"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011071128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OXA-48 family carbapenem-hydrolyzing class D
                     beta-lactamase OXA-48"
                     /protein_id="WP_015059991.1"
                     /translation="MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVV
                     LWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIAT
                     WNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIR
                     ISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWW
                     VGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP"
                     /name="OXA-48 family carbapenem-hydrolyzing class D
                     beta-lactamase OXA-48"
     gene            5383..6080
                     /locus_tag="EL400_RS00035"
     CDS             join(5383..5632,5632..6080)
                     /locus_tag="EL400_RS00035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558260.1"
                     /ribosomal_slippage=""
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1-like element IS1B family transposase"
                     /protein_id="WP_095033700.1"
                     /translation="MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTY
                     TASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTIFRHFKKLRPQSVTSRIQPGSDVIV
                     CAEMDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIW
                     MTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVI
                     GHYLNIKHYQ"
                     /name="IS1-like element IS1B family transposase"
     gene            complement(7285..7698)
                     /locus_tag="EL400_RS00040"
     CDS             complement(7285..7698)
                     /locus_tag="EL400_RS00040"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_168445010.1"
                     /translation="MYAPLKTPSVAFWRKKRKKTRKHQAKPEKRVRIVFMALHNYARKR
                     CAIGFVRSEHRTAQNDKFSPLVRGALTGFPVSKLHISPGQKKTDLGSVARIRVYGKYFS
                     YRMLNIHKRKKCLSDALKQPFQKESALYDARKR"
                     /name="hypothetical protein"
     ARG             complement(4371..5164)
                     /name="blaOXA-48"
                     /gene="blaOXA-48"
                     /gene_name="OXA-48 family carbapenem-hydrolyzing class D
                     beta-lactamase OXA-48"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     Typing          2..776
                     /name="Col156"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="96.778"
                     /coverage="83.0"
                     /evalue="0.0"
     Typing          1695..2617
                     /name="MOBQ"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="98.052"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 atgagcgccg cgcttcaata cttcgacgaa aatttacccc atcgtcccta tcacacggat
       61 gatctcgctt ttggtcttcg catctccggc aaagggcgtg cgcttcttgc gcggtacata
      121 cagcagaacc agcctcatgc gcagttctgg ctggtttttg acgttgaccg cgagggggct
      181 gcgattgact ggagcgaccg gaacgctccc gcgccgaaca tcaccgttaa aaatcctgtg
      241 aacggacacg ctcacctgct ctacgcactc aacatcgccg tgagaaccgc gcctgatgcc
      301 tcggttaagg cgctgaaata tgccgcagcg gttgaacgtt cgctgtgtga gaaactttgt
      361 gcggatgtga actacagcgg cctgatttgc aaaaatccgt tccacctgga atggctggtg
      421 atggagtggc gcgaggaagc ctataccctc gatgaactgg ctgattatct cgatttgagc
      481 gcctcagagc gtcgtagcat cgataaacat tacgggatgg ggcgaaactg ccacctgttc
      541 gaaatgacgc gcaaatgggc ttacagggcg attcgtcagg gctggccagc gttctcacag
      601 tggcttgaag cggtgatcca gcgtgtcgaa atgtacaatg catcgcttcc cgttccgctt
      661 tcactggctg aatgtcgggc tattggcaag agcattgcga aatacacgca caggaacttc
      721 acgccggaaa ctttcgcaca gtatgtggct gatacgcaca cgccagaaat tcaggctgca
      781 cgcggtcgca agggcggttc taagtctaag cgcagcacag tagctacatc tgcacgcacg
      841 ctgaaaccgt gggaggcatt agggatcagt cgcgcctggt attaccaact gaaaaaacga
      901 ggtctcgtag agtagaccaa ataagcctat atcagataac agcgcctttc tggcgtcttt
      961 ttgagcagca ggttttttgc cgtttttccc cgttcagccc tgcaatggcg cggctttccg
     1021 cgtgattgtg gtggtagtgc tcgccgcagt ctcatgaccg agcgtagcga gcgaatgagc
     1081 gaggaagcac cagggaatcg gaacacggat ggaggcactt acgcgtctgg gtttggggat
     1141 gtctccagat cgtacttaag ttccttaagt gcttgtaata tcctgtcttt tttatagcat
     1201 agctcgcctg tttttgtgtc taccagtcct gcttcgatca gtagcccagc cgcgagaaag
     1261 agccggtgat tgcgttcccg tcgttgtttt tttccctcga ttcgtttttg gaccgcctgt
     1321 tttcgttcgc tctcctgtgc ctgtaagtcg tttttttccg ctgttgccag tacgtggaga
     1381 agtttgcgtt cctgttctgt gagtccggct tcgttgtcga tcaggtcaat aatctgtctc
     1441 tgtcgtgcgg tctgttctcc gagcttcctg atgaatccga tccgtttctt cagccattcg
     1501 atgttgctga tgcgcatgtt cgtgatgctc cctggtgttt ttttgcggtg tgttgtggtc
     1561 gtgcagtata tcgcttgcgg tcggcgggtg cagggggtat cttccgtgct aattcgtaaa
     1621 attagaagga agcgcactta tatgtttctc tccttcgtcg agaaacagtg cgctcctgca
     1681 gagggctgaa accgtggcaa cctatcacct cagcgttaaa tttggtggca aggggcaggc
     1741 tgcaaaccac gccgattaca tcgagcgcaa agagaaatac cgcgaccgtc aggatttgga
     1801 atattccgca cacggaaaca tgccggaatg ggccagggat aatccttccc atttctggca
     1861 ggcggctgac cagtttgaac gtgcgaacgg ttcgacctat agggaacttg aaattgcatt
     1921 accccgtgaa ctgacaccgg aacagcgcct tgaactggtg caggattttg tacgtcagga
     1981 agctggcgaa cggcacgcct ggagttttgc cattcacaat ccgaaagcga gcattgacgg
     2041 cggcgaacag cctcatgcgc atatcatgat gagtcagcgt gtgaatgatg gcattgaacg
     2101 tacaccggaa cagtatttcc ggcgctataa cgccaggtat cccgagcggg gaggtgcgaa
     2161 aaaggattcc ggaagcctga ctctcactca gcaaaaagag cagttgcggg aattgcgaaa
     2221 acgctgggag gtgaagcaca acgaacatat gagaaagcat ggctttgaaa ggggcttcat
     2281 tgactgccgg acgctgaaag aacagggcat tgaacgacgt cccgaagtgc atctgggttt
     2341 tgaagctgcc ggacggcttg atgatgccca gcgtcatgac atcatgcaaa aacggtctga
     2401 accggactat tcccgccatc ttgaacaggc gcgaacggtc gggcatgaca tcagggaatg
     2461 gctggacact ccggttaagc aacatgaact ggtcagaagg ctgcaacatg atgttgcgcg
     2521 ggagcatggc tttgacatga gagacagagt gagcagacag aaccgaactg cacctgaacg
     2581 ggttaaatca ccgtcacgtg gattttctat gggattctga acatggccag cacagaagaa
     2641 aaattactca cgctcctgtt atcggtggag catctgcaac ataccgcaat ggagcaacag
     2701 aaagctgttg ctgattctct ggctgtggca agggaaactc ttcgcggata tcgggatatt
     2761 tctgacggtg tggcaaaaca ggtcagggat gaagtcagaa atgaggtgca gaagctggac
     2821 gtggcaggac tgataggtga gcgcatcagc caggattttc agcggctgga agagtcagtc
     2881 gcaaacatga aggcaaacgc ggatgccctg aacagggata ttgcgacaat tcacagcaat
     2941 atcgtgcagg aatacaacac ccttaaaggg tatagctgga aatggctggg tggggtgtca
     3001 gtggcttttc tggttatgtt ctgtgtgctc ggatggggaa tgaaaacaat actcgacagg
     3061 aactacaacg ccacagcggc ggtgtatcag aaagttgtga cactggaaga taaactggtg
     3121 gagaaacctg tcacggggaa gagccggaaa aactgacgcg cttcgcttgt ccaacgcctc
     3181 acgacccgcg aaaggatttc gcgaaccgtt caccgttttt ttcaatatga ttctgtctgc
     3241 tttggtcgat aaagcagacg atagtattcc agccttcgta tatataacgg tacgtgctca
     3301 tcagtaagag ctggcggtat tgtgttatca gggggaagtt ttttcagata ctcacgaaat
     3361 gcctggcttg atgccataaa atctacagta gcatcgatag gtaatgactc caacttactg
     3421 atagtgtttt atgttcagat aatgcccgat gactttgtca tgcagctcca ccgattttga
     3481 gaacgacagt gacttcctgc ccagccttgc cagatgttgc ctcagattca ggttatgccg
     3541 ctcaatgcgc tgcgtatatc gcttgctgat aacgtgcagt tctcccttca ggcgtgattc
     3601 ataaagcggc cagccatccg tcatccatac cacgacctca aaggccgaca gcaggcccag
     3661 aagacgctcc agcgtggaca acgtgcgttc accgaatacg tgcgccacaa ccgtcctccg
     3721 tatcctgtca tacgcgtaaa acaaccagcg ctggcgtgat ttagcgccga cataacccca
     3781 ctgttcgtcc atttccgcgc aaacaatgac gtcactgccc ggttgtatgc gtgaggttac
     3841 cgactgcggt ctgagttttt taagtgacgt aaaatcgtgt tgaggccaac gcccataatg
     3901 cgtgcactgg cgcgacatcc gacgccattc atggccatat caatgatttt ctgatgcgta
     3961 ccgggttgag aagcggtgta agtgaactgt agctgccatg ttttacggca gtgagagcag
     4021 agatagcgct gatgtccggc agtactttta ccgttacgca ccacgccttc agtagctgaa
     4081 caggagggac agctgataga aacagaagcc actggagcac ctcaaaaaca ccatcataca
     4141 ctaaatcagt aagttggcac cattacccaa attggctagg ctttttacgt tgaggaatgt
     4201 gatgctaatg ctcaggctaa aagttaacgc gcggagctta agtcgattag gcctaaccga
     4261 ttaagtatga gccattaact acaagcgcat cgagcatcag cattttgtcc atatatcttt
     4321 acagcttata tgacggctat ttcacacaaa tacgcgctaa ccacttctag ggaataattt
     4381 tttcctgttt gagcacttct tttgtgatgg cttggcgcag ccctaaacca tccgatgtgg
     4441 gcatatccat attcatcgca aaaaaccaca cattatcatc aagttcaacc caaccgaccc
     4501 accagccaat cttaggttcg attctagtcg agtatccagt tttagcccga ataatatagt
     4561 caccattggc ttcggtcagc atggcttgtt tgacaatacg ctggctgcgc tccgatacgt
     4621 gtaacttatt gtgatacagc tttcttaaaa agctgatttg ctccgtggcc gaaattcgaa
     4681 taccaccgtc gagccagaaa ctgtctacat tgcccgaaat gtcctcatta ccataatcga
     4741 aagcatgtag catcttgctc atacgtgcct cgccaatttg gcgggcaaat tcttgataaa
     4801 caggcacaac tgaatatttc atcgcggtga ttagattatg atcgcgattc caagtggcga
     4861 tatcgcgcgt ctgtccatcc cacttaaaga cttggtgttc atccttaacc acgcccaaat
     4921 cgagggcgat caagctattg ggaattttaa aggtagatgc gggtaaaaat gcttggttcg
     4981 cccgtttaag attattggta aatccttgct gcttattctc attccagagc acaactacgc
     5041 cctgtgattt atgttcagta aagtgagcat tccaactttt gttttcttgc cattcctttg
     5101 ctaccgcagg cattccgata atcgatgcca ccaaaaacac agccgataag gctaatacac
     5161 gcataacgtc cccttgctta atgcaatata ctgaagaatc ccctgatgat ttacaaataa
     5221 atcatcaaat tagggtggaa gcgcatcttg ttgcatgatc aaatggtttc gccaaaaact
     5281 acacttggac aacaagatgc gcgaagccaa tatcctacaa cattcttggt gatgctgcca
     5341 acttactgat ttagtgtatg atggtgtttt tgaggtgctc cagtggcttc tgtttctatc
     5401 agctgtccct cctgttcagc tactgacggg gtggtgcgta acggcaaaag caccgccgga
     5461 catcagcgct atctctgctc tcactgccgt aaaacatggc aactgcagtt cacttacacc
     5521 gcttctcaac ccggtacgca ccagaaaatc attgatatgg ccatgaatgg cgttggatgc
     5581 cgggcaaccg cccgcattat gggcgttggc ctcaacacga ttttccgcca tttaaaaaac
     5641 tcaggccgca gtcggtaacc tcgcgcatac agccgggcag tgacgtcatc gtctgcgcgg
     5701 aaatggacga acagtgggga tacgtcgggg ctaaatcgcg ccagcgctgg ctgttttacg
     5761 cgtatgacag gctccggaag acggttgttg cgcacgtatt cggtgaacgc actatggcga
     5821 cgctggggcg tcttatgagc ctgctgtcac cctttgacgt ggtgatatgg atgacggatg
     5881 gctggccgct gtatgaatcc cgcctgaagg gaaagctgca cgtaatcagc aagcgatata
     5941 cgcagcgaat tgagcggcat aacctgaatc tgaggcagca cctggcacgg ctgggacgga
     6001 agtcgctgtc gttctcaaaa tcggtggagc tgcatgacaa agtcatcggg cattatctga
     6061 acataaaaca ctatcaataa gttggagtca ttaccgcatc gataatatgt ggggtgtttt
     6121 cacctaattt tgccatgatg ataatcctta tattatcacg gtttgtgaat gatagggtgt
     6181 cactattatt tatgcgttag tgaaccagaa aaaatccccc gttggcatag ggggatatgt
     6241 aaggagaaat aacttcgcag gtgttcttgt ttgtataacg tgaaaagact gcacgcaact
     6301 taataagtct gccgtactta ctttcagttt tcaacataag gtttataaca atgtatggaa
     6361 tggaagtgag ctttaaggtt tcagctctaa aaaataaaat atttattagt tggctggttg
     6421 ttgttcttgt tctgtatgta tataaacact atcgacatat tatgaccggg aacattcctt
     6481 accccctctg cgctcgcaga ggtttttttt gtcattaatt aataatgaac tgaaatgcag
     6541 ttccgatacc tccatttgca cattatccct gacatatggt accggaaccg cattaatttt
     6601 atgttataag agtttatttt taatgtccag atggtttaat agtatttata tgtaattagc
     6661 tgtatggata gtactggttt tattgtataa cttgtcgttt ttttttattg tttttgtgtg
     6721 gtgtgctaat ctttaagtta taaaaaaacc ccttggaata caggggcaaa agtaaggaaa
     6781 acaaatggat gctcagtttg tgtgacactt taaactaatg gaactataga gtggaggttg
     6841 ttacagtcgc ttttataaaa cagcaaccag tttttttcaa tagtctgatg atggttgtga
     6901 cagttttgtg atattgttca aaatgtttct tgttgaatgt ttgttttttg gtctattggt
     6961 gtctggtttt attttttctg ctattacata tcaagaaatg tgattggtgt agcaagagtg
     7021 gaatgcgatg tggataaact aattggttgt cgaatctaat ttacttagaa aactacactt
     7081 gtttttgtgt atgaatttag tgaatttgtc tgtctatgtg ttttcgtgca tttataaatc
     7141 cttcgtcagg atcttaaatt tagtgttgaa tatgtagggc ctgtacggta attattattt
     7201 agcgtagcta cttcatcgtt gttcgaacac aaccaacaac ctgtaattgt tgtttctctt
     7261 ggttccccac ttttgtgggg ttttttatct cttccgtgca tcgtaaagcg cggactcctt
     7321 ctggaaaggt tgttttaggg catcactgag gcattttttg cgtttgtgaa tattgagcat
     7381 ccgataacta aaatatttcc catagactct gattcttgcc accgacccca ggtcggtttt
     7441 tttttgtcct ggcgagatgt gaagtttgga aacaggaaac cccgtcagag cgccacgcac
     7501 caggggagaa aacttgtcgt tttgagccgt tcggtgttca gaacgcacga aaccgatcgc
     7561 acatcgcttt cgtgcatagt tatgcaacgc catgaaaacg attctgacgc gtttttctgg
     7621 tttggcctgg tgttttcttg tctttttgcg ttttttgcgc cagaaagcga ctgagggcgt
     7681 tttaaggggg gcgtacaacg ggagttatgg taaatggatc gggttttcgg gaaggttcga
     7741 caggatttgc cgttgggtgt agtgtaagcg actgaaaaac aaacgcccct gaaatcatgt
     7801 ccagatccgg caagattcaa catgaaatac agagggcgtg taggtcgcat aacccggaga
     7861 gaatcgtaac ac
//
