LOCUS       NC_013453              17256 bp    DNA     circular CON 27-MAR-2024
DEFINITION  Staphylococcus aureus subsp. aureus ED98 plasmid pAVX, complete
            sequence.
ACCESSION   NC_013453
VERSION     NC_013453.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN02604165
            Assembly: GCF_000024585.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus subsp. aureus ED98
  ORGANISM  Staphylococcus aureus subsp. aureus ED98
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 17256)
  AUTHORS   Lowder,B.V., Guinane,C.M., Ben Zakour,N.L., Weinert,L.A.,
            Conway-Morris,A., Cartwright,R.A., Simpson,A.J., Rambaut,A.,
            Nubel,U. and Fitzgerald,J.R.
  TITLE     Recent human-to-poultry host jump, adaptation, and pandemic spread
            of Staphylococcus aureus
  JOURNAL   Proc Natl Acad Sci U S A 106 (46), 19545-19550 (2009)
   PUBMED   19884497
REFERENCE   2  (bases 1 to 17256)
  AUTHORS   Lowder,B.V., Guinane,C.M., Ben Zakour,N.L. and Fitzgerald,J.Ross.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2009) The Roslin Institute and Centre for
            Infectious Diseases, Royal (Dick) School of Veterinary Studies,
            University of Edinburgh, The Chancellor's Building, New Royal
            Infirmary, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland,
            UK
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000024585.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 01:05:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,856
            CDSs (total)                      :: 2,776
            Genes (coding)                    :: 2,692
            CDSs (with protein)               :: 2,692
            Genes (RNA)                       :: 80
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 84
            CDSs (without protein)            :: 84
            Pseudo Genes (ambiguous residues) :: 0 of 84
            Pseudo Genes (frameshifted)       :: 46 of 84
            Pseudo Genes (incomplete)         :: 38 of 84
            Pseudo Genes (internal stop)      :: 32 of 84
            Pseudo Genes (multiple problems)  :: 29 of 84
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP001784.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..17256
                     /organism="Staphylococcus aureus subsp. aureus ED98"
                     /mol_type="genomic DNA"
                     /strain="ED98"
                     /sub_species="aureus"
                     /db_xref="taxon:681288"
                     /plasmid="pAVX"
     gene            complement(125..493)
                     /locus_tag="SAAV_RS14430"
                     /old_locus_tag="SAAV_c01"
     CDS             complement(125..493)
                     /locus_tag="SAAV_RS14430"
                     /old_locus_tag="SAAV_c01"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_041203784.1"
                     /translation="MKDFFYGDPWFTFLIYRENRRGKSKDSKLGFYLAGDKELMVSVRK
                     HFSNVYPNIEFHEADESHLDFPTKRSYFGYAKLKHNSLKQGYPIEIFQHDNLTKIVSIM
                     EPDTWLQFRFRRNYGFKL"
                     /name="hypothetical protein"
     gene            complement(1355..2929)
                     /locus_tag="SAAV_RS14440"
                     /old_locus_tag="SAAV_c02"
     CDS             complement(1355..2929)
                     /locus_tag="SAAV_RS14440"
                     /old_locus_tag="SAAV_c02"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primase C-terminal domain-containing protein"
                     /protein_id="WP_000932174.1"
                     /translation="MLNINKIYDFILHGSIEKYKFKNSKATDLEKANFKATQPRNWRSA
                     RIAVTPNKATLIDGLGLIIASEEALVQYGHKFSHWTPNPYNYLSKEKANIADVNTYKVL
                     NRTKDNVKQINTFVLDVDEDIEYNELVQSLASAHINEGAELPNLYVKTPRGWHLYFVLD
                     TPFYAKGIEKKAIKVAEKVHSSLAHAISKYLPVDNQCVSTGYFRLPTKDNVQLFTNQYC
                     SKSYMVRWSKEYSEKHNLNQNVLYKSIANGQELTPEWVDYLLKEADVTSFGYGVGRNNA
                     MFSVALYYYSKNIDMKVAESNIYAFNQRLNQPLSHKEVERVIKSAYSGRYGGAMREHVE
                     NLLEAFTDGQIAYSNSGVSINGFWKHKKERKDRVRSHFDERKADLERYLNEHTNKQKVF
                     VKGSMSAIAKKLGMARSSLYAVFEKHINKGTIIKYTIKNGRYSETFIALKSVYIESLFE
                     MVKSIKNKKESYITAIRHLVSSERNTHSLMVQNNGLLNEIENTLTYIDRHTQYIEGNEI
                     LYERFIS"
                     /name="primase C-terminal domain-containing protein"
     gene            complement(3321..3569)
                     /locus_tag="SAAV_RS14445"
                     /old_locus_tag="SAAV_c03"
     CDS             complement(3321..3569)
                     /locus_tag="SAAV_RS14445"
                     /old_locus_tag="SAAV_c03"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001632623.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_001004832.1"
                     /translation="MNENILLELCSKLKGIRKGKKYTQQEVADIIGINIWTVNRIENKK
                     LEEVKLKTILRILDLYEITLYEFIEDNKDIVNRAYNK"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(3582..4136)
                     /locus_tag="SAAV_RS14450"
                     /old_locus_tag="SAAV_c04"
     CDS             complement(3582..4136)
                     /locus_tag="SAAV_RS14450"
                     /old_locus_tag="SAAV_c04"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001062591.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001062591.1"
                     /translation="MAKIGYARVSTISQSLETQINLLKAEGCIKIFSEKVSGKKTNRSK
                     LDECLKYLREDDVLVVTKIDRLGRTTKQLINLASWLQEHNIELKILDGNFNMNSPLGKM
                     IFTVMSGFAELETDLNRERTLEGLNEAKARGRKGGRPGVTKDVKNYVMYLYNNTELSGN
                     EIARKTGVSRSTVYRIKRDFN"
                     /name="recombinase family protein"
     gene            <4876..5379
                     /locus_tag="SAAV_RS14455"
                     /old_locus_tag="SAAV_c06"
                     /pseudo=""
     CDS             <4876..5379
                     /locus_tag="SAAV_RS14455"
                     /old_locus_tag="SAAV_c06"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558064.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /name="IS30 family transposase"
     gene            complement(<5385..>5588)
                     /locus_tag="SAAV_RS15180"
                     /pseudo=""
     CDS             complement(<5385..>5588)
                     /locus_tag="SAAV_RS15180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001622542.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA];
                     GO:0042626 - ATPase-coupled transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter transmembrane domain-containing
                     protein"
                     /name="ABC transporter transmembrane domain-containing
                     protein"
     gene            <5726..6032
                     /locus_tag="SAAV_RS15185"
                     /pseudo=""
     CDS             <5726..6032
                     /locus_tag="SAAV_RS15185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001622764.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /name="transposase"
     gene            complement(6116..6433)
                     /locus_tag="SAAV_RS14460"
                     /old_locus_tag="SAAV_c09"
     CDS             complement(6116..6433)
                     /locus_tag="SAAV_RS14460"
                     /old_locus_tag="SAAV_c09"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001830557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="staphostatin A"
                     /protein_id="WP_000049867.1"
                     /translation="MSKYQLINIKDNNLEFSEKYWLHILQGVWRPEKISTKPLKITFNK
                     NIFPIYICKEINEDSRRIILNNTDNTNIIIEIIIINHKKIIFNVLNKLSLGVTPKITFI
                     K"
                     /name="staphostatin A"
     gene            complement(6454..7653)
                     /locus_tag="SAAV_RS14465"
                     /old_locus_tag="SAAV_c10"
     CDS             complement(6454..7653)
                     /locus_tag="SAAV_RS14465"
                     /old_locus_tag="SAAV_c10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366922.1"
                     /GO_function="GO:0008234 - cysteine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C47 family peptidase"
                     /protein_id="WP_001074681.1"
                     /translation="MAKKICNISTIVFVLAIGLILSLVFSLFFNNVNAEEASQKELPNQ
                     KNTKVNIDKKDIPSAVKKLAEDQYLSRVAALDKLSGEKNSSYTLGEAFKIYKFNQKSDG
                     NYYFPVLNKEGKVVYVVTISPKIANDKNTSSNSDYTINVSPFLSKILNQYENQKFTILT
                     NTKGYFVVTEDNKIKHVLKTPYSGEKNSKNTMESPKNIDLKNFKQTASVTKPIIQFENP
                     KYGVRAQYVNQLKNFKIRETQGNNGWCAGYTMSALLNATYNTDRYNAEAVMRYLHPNLQ
                     GDDFQFTGLTPQEMMKYGKSQGRDTQYLNRMPSYNEVDKLTTNNKGIAILGSRVESTDG
                     IHAGHAMAVVGNAELEGGQEVIMIWNPWDRGFMTQDAESNIIPVSNGDHYQWNSSIYGY
                     "
                     /name="C47 family peptidase"
     gene            complement(8147..>8503)
                     /locus_tag="SAAV_RS15190"
                     /old_locus_tag="SAAV_c11"
                     /pseudo=""
     CDS             complement(8147..>8503)
                     /locus_tag="SAAV_RS15190"
                     /old_locus_tag="SAAV_c11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558064.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /name="IS30 family transposase"
     gene            complement(8845..9087)
                     /locus_tag="SAAV_RS14475"
                     /old_locus_tag="SAAV_c12"
     CDS             complement(8845..9087)
                     /locus_tag="SAAV_RS14475"
                     /old_locus_tag="SAAV_c12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002437031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_044290595.1"
                     /translation="MAGFLDNIKVVGQQKRGFLDDIDTSAVKYTENYKPMAKSSTMRVD
                     TLIKRRLSQMALDKDTSIKAISDKVLQEFLEKNNY"
                     /name="hypothetical protein"
     gene            complement(9097..9888)
                     /locus_tag="SAAV_RS14480"
                     /old_locus_tag="SAAV_c13"
     CDS             complement(9097..9888)
                     /locus_tag="SAAV_RS14480"
                     /old_locus_tag="SAAV_c13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000111526.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="WP_000111526.1"
                     /translation="MSVITIGNFKGGVGKTTVSTLLSYIGSERYDKRILLVDFDPQGNA
                     TQIMKRTYPEAIDEKQTFIDALKTGELEDSIINLSTKLSLLPADSSLANLSDIIAKTDI
                     IKKRYILKTVIDQIKKNYNFDYIFIDVPPTINSDFTNNAVYASDYIAMVFQTQQSAYES
                     SLSFVNFLRDRKKESNLPFELIGAIPVLIKKNGNIDEYILEISKKTFSNALFKNQIFQR
                     ERIKKFGAEGIRDKDVHDKRVLHMLEAIYKELIERIELIEG"
                     /name="ParA family protein"
     gene            10018..11301
                     /locus_tag="SAAV_RS14485"
                     /old_locus_tag="SAAV_c14"
     CDS             10018..11301
                     /locus_tag="SAAV_RS14485"
                     /old_locus_tag="SAAV_c14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002440692.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_000083517.1"
                     /translation="MSQSLRFTKLYKFLFEDPTFKTLPAKAKLLYALISERQSLSKANA
                     KQHGIQSQFIDNEGRLFSIYTNQELMTKLNMSKPTVIKLKKQLIEFGLLEDVRLGNNQP
                     NRLYPKKPYDNYFYAYDVDEFYRLPHALFENPKYQSLAAESIIAYAIYLSRYEYSIYKN
                     HFSDENGAVYCCFSNDNMANILDVSTRKVERIKKELIVSSLMINKRASFGKSNRLYISL
                     PKASDDKEVKKCRTSYTYFSYTYSSDIDSNDMNDTYDNNIDEVHEINDSPQTNHSSHPN
                     HQHNTEDTFNDQQVEQEMLLQHLPDYVQLNLKHFSNTEIRCIKSVLNKAKASYNHHAPV
                     DERVTYEACTYAIGEALRRIKLLSRQKNENICDLEAYMMQTFKRVFVEHVLNDQQKLDD
                     TKTKTHDISQFEPKNAFQSMAKRMFLDV"
                     /name="replication initiator protein A"
     gene            11333..11566
                     /locus_tag="SAAV_RS14490"
                     /old_locus_tag="SAAV_c15"
     CDS             11333..11566
                     /locus_tag="SAAV_RS14490"
                     /old_locus_tag="SAAV_c15"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001002995.1"
                     /translation="MNEKEIGIAFLNHFTQVEAYLEALGVPENHIADIKPIVIQNYPYE
                     RFLFDDLGDVTNVIIPFSKVIGSNLFGNIGYK"
                     /name="hypothetical protein"
     gene            11576..11986
                     /locus_tag="SAAV_RS14495"
                     /old_locus_tag="SAAV_c16"
     CDS             11576..11986
                     /locus_tag="SAAV_RS14495"
                     /old_locus_tag="SAAV_c16"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000872163.1"
                     /translation="MKWSLEQNFHGNAPNLKPQKIQGCLGFLKSLGWENWNQSYQTLDI
                     GELYFSLLLDDKGHVITYMHEGGNGGGRHRIFTGKVCGAEYVRAARLTQFRLNKQKLAY
                     YKNNWYLSNKLKILFKKVNCFKLFVSYILFMF"
                     /name="hypothetical protein"
     gene            complement(12138..12812)
                     /locus_tag="SAAV_RS14500"
                     /old_locus_tag="SAAV_c17"
     CDS             complement(12138..12812)
                     /locus_tag="SAAV_RS14500"
                     /old_locus_tag="SAAV_c17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WP_001106066.1"
                     /translation="MNYFRYKQFNKGVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPIVYQIWKKKHKKAYYKWRIDETYIKIKGKWNYLYRAIDAEGHTLDIWL
                     RKKRDHQSAYAFIKRLIKQFGKPQMIITDQAPSTKVAMTKIVKVFKLNPNCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSLNTAKNTLKGIECIYGLYKKNRRSLQIYGFSPCYEISHML
                     AS"
                     /name="IS6 family transposase"
     gene            complement(13391..14074)
                     /locus_tag="SAAV_RS14505"
                     /old_locus_tag="SAAV_c19"
     CDS             complement(13391..14074)
                     /locus_tag="SAAV_RS14505"
                     /old_locus_tag="SAAV_c19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019168208.1"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="WP_000277644.1"
                     /translation="MYKNLNNIHQSHYLALIYIILLIIIPRYAILPFSNKLNINYDIIN
                     EWYFFVITTILMIYAIKIFKVKLQKDWLNIKNKKIGVFLTGIVGFFLILLLNVILILII
                     NQGRPVKSVNQNAIENISFLSQFFAPLLIVIIGPILEELLFRVYILEVLKNKIKLLPAI
                     LISISSFTVIHMHSLTEDWKTLIPYFSIGIVTVFIYLKKHNFYYILSIHVLNNLVAQIA
                     IWFLQ"
                     /name="type II CAAX endopeptidase family protein"
     gene            complement(14249..14587)
                     /locus_tag="SAAV_RS14510"
                     /old_locus_tag="SAAV_c20"
     CDS             complement(14249..14587)
                     /locus_tag="SAAV_RS14510"
                     /old_locus_tag="SAAV_c20"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002436882.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003723 - RNA binding [Evidence IEA]; GO:0004521 - RNA
                     endonuclease activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /protein_id="WP_001022435.1"
                     /translation="MNIKQFDILYIDLNPTRGREKHNVRPCLVINNQMSIDGTNFVWVL
                     PITTRGLRYPTDIQLKTKKGLVSGVIDTVQIRALDLKARQYNYKDELQDNLKNDILKAI
                     KTYLKPTL"
                     /name="type II toxin-antitoxin system PemK/MazF family
                     toxin"
     gene            complement(14584..14853)
                     /locus_tag="SAAV_RS14515"
                     /old_locus_tag="SAAV_c21"
     CDS             complement(14584..14853)
                     /locus_tag="SAAV_RS14515"
                     /old_locus_tag="SAAV_c21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002477818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001129937.1"
                     /translation="MAKSLKDLNKTSERVFKNGNSKAISLSKKTIRLANFDIGDTVEVQ
                     KMNGGLFITKKKESIEDRIKNFFQSGGKYTELEVDWEERVGREI"
                     /name="hypothetical protein"
     gene            15424..16233
                     /locus_tag="SAAV_RS14520"
                     /old_locus_tag="SAAV_c22"
     CDS             15424..16233
                     /locus_tag="SAAV_RS14520"
                     /old_locus_tag="SAAV_c22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002491360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_001106667.1"
                     /translation="MNYIKYIHSVDGTTLYVKVNENVNSSANIIICHGLAEHLDRYDEI
                     SNYLQEKNFNIIRFDQRGHGRSGGKRTFYSNVNEIVEDLDAVINFTKEHYKGNIYLIGH
                     SMGGYGSVLYSTKNPGKINGLIISGAVTRYNQKTFGDIDDTIDRNKYINYEIGEGVCSD
                     TFELEKYRLDALTEKKVSYGLIYTVLEGVKGLVENAQYFDDNILILHGKDDGLVHYSDS
                     LDFYKNISSSKKELHIYDGLQHEIFNERKKNKEIFSEIANWINNDLT"
                     /name="alpha/beta hydrolase"
     gene            16346..17077
                     /locus_tag="SAAV_RS14525"
                     /old_locus_tag="SAAV_c23"
     CDS             16346..17077
                     /locus_tag="SAAV_RS14525"
                     /old_locus_tag="SAAV_c23"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019168209.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_000753929.1"
                     /translation="MKKTTIYFVLYFIISALGFGMLKKLGIEYNSLEIAVYALPMMIIL
                     SIFVYSIALNPYQKRKSSPIIHVKSLEYVVPLVILCDILIILELLYTGNFRPILVAQLF
                     LTFLIGFSEEFFFRKYIIEHILTKYKSKLLALITSSILFGLLHMANTFGGLTIENAASQ
                     SMSATGVGLLYGLIYIFTKKIWMLVLLHMNVDFALFSSVINQSYLQAVPAFIVDIILIF
                     TVLKIIMYILKSIKSKNNKFL"
                     /name="CPBP family intramembrane glutamic endopeptidase"
     Typing          complement(1431..2929)
                     /name="rep_cluster_155"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          10019..10749
                     /name="rep_cluster_2439"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="97.951"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 tatcaaaagc aacatcacta tacgtaaaac gtttgttggt ttctttccaa atctcctttt
       61 cataattatc ccgatcttta aatttttgct ctctaatatc ttcatcagtc ttttttatag
      121 cttttcataa cttaaaaccg taatttcttc taaatctaaa ttgtaaccat gtatcaggtt
      181 ccataatact aactatctta gttaaattat catgttgaaa tatttctata ggataaccct
      241 gttttaaaga attatgtttt aacttagcat aaccaaaata tgatctttta gtaggaaaat
      301 ctaaatgact ttcatctgct tcatgaaatt ctatatttgg ataaacattg ctaaaatgtt
      361 ttctaactga aaccattaac tctttatccc ctgctaaata aaaacctaat ttgctatctt
      421 tactttttcc tcgtctattt tctctataga ttaaaaaagt aaaccaagga tctccataaa
      481 aaaaatcttt caaaaatatt tcttctagtc gaatgaatat ttttcaataa tttaaaaatt
      541 ttatcagatt taggaaaatc tccctcataa gttaatattc tataatattc catatttttc
      601 tgtattttaa ttattttcat aatatatcgc aacaacatag aaaatattat taatacaatt
      661 gcaaaaattg caccagcgat cagtgatgct cgcgctgtga aaaatatgag tagtgaaagg
      721 ataaggatat aggatatgaa taaggagagt tgtctaagaa gtttagacgt catatgtgga
      781 tacctcccgt ttgtatttgg ttgtcaaggt acagtggata tgtcgccccc gcatttaaca
      841 aataaaaaac aaagtcttct ccagttacga ttaattaaga tgatgatatt attctatgaa
      901 taatgtaatc ttatttaatc taacaggaaa tagtcacgaa aaataccggg ttttatatcc
      961 ttaattacat ttcaccttaa aaagactata aaaacaatat ttaatttgta tatcatgtta
     1021 tgtgttatgt agttcattat ggtatggatt atgtaatgaa tttaatcaaa gcataatcta
     1081 attatattaa tcttaataca tagtataata cgtcatatat tcacaccata atcaaacgca
     1141 atatacaccc ataatatata attgttaatg gggagagatc tccattttgt taaaatattt
     1201 taggtaattt ttaatttttt ggcgcctgct aattttaatt agtaggcgtt tttctattat
     1261 tctacataac tacttaacta ctcacttata tatattattt acagaaacgc acaaacaccc
     1321 tgatatatgt aatggcacat cggacaatta aaatttaact aataaaccgt tcatatagaa
     1381 tttcattacc ttctatatat tgagtgtgcc gatctatata agtgagtgta ttttctattt
     1441 cattcaacaa accgttattt tgtaccatta aactatgtgt atttctttca ctgcttacaa
     1501 ggtgtcttat agccgttata tagctttctt ttttgttttt aatactttta accatctcaa
     1561 ataaactttc aatatacacg ctttttaaag caatgaaagt ttctgaatat ctaccgtttt
     1621 taattgtgta tttgataata gttcctttgt ttatatgctt ttcaaaaact gcatataaag
     1681 atgatctagc cattcctaac tttttagcaa tagcactcat tgagccttta acaaacactt
     1741 tctgcttatt tgtatgttca tttaaatatc tttctaaatc ggctttacgt tcgtcaaaat
     1801 ggcttctaac acgatcttta cgctcttttt tatgtttcca aaagccattg atacttacac
     1861 cactattgct atatgcaatt tggccatcag taaaagcttc taaaaggttt tctacatgtt
     1921 cacgcattgc gccaccataa cgaccgctat aagcactttt aattactctt tcaacttctt
     1981 tatgtgataa aggctgattt aagcgctgat taaaagcata gatattactt tctgctactt
     2041 tcatatctat atttttagaa taataatata acgctactga aaacattgcg ttatttctac
     2101 caacgccata tccaaatgaa gtaacatctg cttcttttaa caaataatca acccattcag
     2161 gcgttaattc ttggccattg gctatactct tataaagtac gttctgattt aaattgtgct
     2221 tttctgaata ctctttactc cagcgcacca tataagattt tgaacagtat tgatttgtaa
     2281 ataactgaac attatctttt gtaggcaatc tgaaatagcc agtagataca cattgattat
     2341 cgactggtaa atatttagaa attgcatgtg ctaagctact atgtactttt tcagctactt
     2401 ttatcgcttt cttttctata cctttagcat agaacggtgt atctaataca aaatataaat
     2461 gccaacctct aggcgtcttt acatacaaat taggcaattc agcgccttca ttgatatgcg
     2521 ctgaagctaa gctttgaact aattcattat attcaatatc ttcatcaaca tctaaaacaa
     2581 atgtattgat ttgttttaca ttatcttttg ttctgtttaa cactttatac gtattaacat
     2641 ctgctatatt agctttttcc ttacttaaat aattatatgg attaggcgtc caatggctaa
     2701 atttatgacc atattgaact aaagcttctt ctgaagcaat aattaagcct aaaccgtcta
     2761 ttaatgtagc tttattaggt gtgacagcaa tacgtgctga tctccaattt cggggttgtg
     2821 tagccttaaa attagctttt tctaaatctg tagctttaga atttttaaac ttatactttt
     2881 ctatgcttcc atgtaatata aaatcataaa ttttattaat atttagcatt gtctgcacct
     2941 cctaaacaaa aaagactgat aacacttgta agcgttacca gtccttgttt aggcgtccat
     3001 atacatttaa agtagtcgag tagcgaagta gaaaagtaga aaagtagcgt ctttttcttt
     3061 actttcttct ctcatgcccc tataatttag gtatacaaaa taatttaaaa atacctaaat
     3121 cataaaggta tggaagaaga cccgaaaacc gtttgtatac gttagtgagg taacgtttca
     3181 agcgctagaa gttaaaaatg ttggtagcaa ttttaacttt gcacgtggtc ttttttcata
     3241 tctttttttg attaattcta gtataaactt ctatattgac gattgcaata attttggtac
     3301 atttgcaaat aaattaaatg ttacttgtta tatgctctat ttactatatc tttattatct
     3361 tctataaatt cataaagtgt gatttcatat aaatcaagta tacgtaaaat tgttttaagt
     3421 ttaacttctt ctaatttttt attttcaatt ctgttcacag tccatatatt aattcctatt
     3481 atgtcagcaa cttcttgttg tgtgtacttc ttacccttcc ttatcccttt aagtttagaa
     3541 cataattcta ataatatatt ttcattcatc ttttttcccc cctaattaaa atcacgtttg
     3601 atacgatata ctgttgatct acttacacct gtttttctcg caatttcatt acctgataac
     3661 tctgtattat tgtatagata cataacatag ttctttacgt ctttcgtaac acctggtcgc
     3721 ccgccttttc ttcctctagc tttcgcttcg tttaaacctt caagagttct ttctctattt
     3781 aaatctgttt ccagttctgc aaagccactc attacagtaa atatcatttt tcctagtggg
     3841 ctattcatat taaaatttcc atctaatatt tttaattcta tattgtgttc ctgtagccaa
     3901 cttgctaaat ttattaattg tttagttgtg cgtcctaatc tatcaatttt agtcacaact
     3961 aatacatcat cttcccttaa atattttaag cactcatcta atttacttct atttgttttc
     4021 ttgccactta ctttttcaga aaatatttta atacaacctt cagcctttaa taagttaatt
     4081 tgtgtttcta agctttgact gattgttgaa actcttgcat agcctatttt agccaaaata
     4141 tcgcctactt cctttataaa tagctttaat atgaacgatt gtgtgtgcgt ttacgtataa
     4201 tgggcttcaa aatatttttt cgcggcgtct gagggcttct ctcagcttgg tcaaaaaccc
     4261 tttttacctt taattttgac actttgattt taacacatat tttgaccagg cacgaatata
     4321 gttaaaggct tatagaattt attcagttct acaagccttt aatccttaca aatagcactt
     4381 attcaagcat attttttatt attttatttt acttattgaa atatattatt ttctaatgtc
     4441 ataccctggt caaaaccgat cggttttgac taggttatgt tagaaacagt actttttgac
     4501 tgtctataaa acggaggttt atagacaaca gtaactaaaa tatattataa agtacgaaga
     4561 aggatagtaa atcccttata tttaaggtgt ttattatcct ttttatattt aatacaatgt
     4621 ctatttactt atctataaat caatgtatat aatatactta aaaaaaggtt ttatagacat
     4681 tagtaaggag gggaaaatgg ctaaaatcgg ttatgctaga gtttcaacta aagatcaaaa
     4741 cttaggttct gttgtaaagt tagaaaaagt atagctaatc atcattttat catgtcagtg
     4801 ttcgtttaac tagctaacac tgaaatgata aaaaaggaaa ttagatgttt ttctaacttt
     4861 gcaacagaac cagaatttcc tttattcaat aaggagtttg ggcatcttga aagagatact
     4921 attgttggtc gtcgtcatgg tagtgcaatc attactttgg tagaaagagt ctccaagatg
     4981 attatcacct tgcgaccctt aggtcgtaag gcaaccgata tagaaaatgc tctgcactca
     5041 atgttttcag ctttaccttc tcatatattt aaatcaatta cttttgattg tggtaaggag
     5101 ttttcaaact ggaaaacaat atgcaactgt catgatatat ctatattttt tgctgatcca
     5161 ggcacgccat cacagagagg cttaaatgaa cattctaacg gaatacttag acgcagtgga
     5221 ttagataaag aactagattt caatttagta acagacaatc atatcatcag tgttgctcaa
     5281 aaaatcaatc atcgtcctag aaaatcttta ggttatagaa caccattgga agtatttatg
     5341 agtttcatcg aagatgataa actgtccagc ttaatttgat aatctaaaat cttaaaaaat
     5401 aaaggaataa taacaaaagt acacaaagtc attttccaat ccaatataaa aagcataatt
     5461 atggaaccaa taattgttaa tacattaggt aaagtaatgg gaaccttatg tgatataaaa
     5521 gtatttataa cctttgtatc gtctactatc ctacttaata attctccact ttcactcgaa
     5581 tcaaaaaaat aactatgctc aaaaaaggta tgtttaatga acctctattt attttgttta
     5641 ctagctctcc cgtaaataat ggtagcgaat ttactttttc agtattaatc attatgctat
     5701 gtatctcatt tagaaatcac cccaaaggtt atgcaataag acgaaattta ttaatcgttt
     5761 gaattctgtt agtagaaagt ctataagtaa agatatctag aaagttgtta actattatag
     5821 gaagaatcaa agaattctaa gaaatacaat ttatcatcca gtatttaata atagatttat
     5881 ggaaggaatt aataataaga taaagttaat tgaacgaatt tcttttggct acagaaattt
     5941 taacaacttc aaaacatgca tcatgatgat tttcagttta tatcaagttg aaaaagaaga
     6001 caaccaagcc taatattgga ctggttgcct aaaaataaat actctcagaa ttattattta
     6061 aaatagttta ttagtatcta aaaatcataa aattgaaaga gttactttaa gctgtttatt
     6121 tgataaaagt aattttaggt gttactccta aagataactt attcaacaca ttgaaaataa
     6181 tctttttatg gttgattata attatttcta taataatatt agtattgtcg gtattattta
     6241 aaattatcct ccttgaatct tcattaattt ctttacatat atatattgga aaaatatttt
     6301 tattaaaagt tatttttaaa ggttttgttg aaattttttc tggtcgccat actccttgga
     6361 gtatatgaag ccaatatttt tctgagaatt ccaaattatt atctttaata ttaattaatt
     6421 gatatttact cataagtttg cctttttata ttattaatac ccataaatag aactattcca
     6481 ttgataatga tctccattag atactggaat aatattactt tcagcatctt gagtcataaa
     6541 accacggtcc caagggttcc aaatcataat cacttcttgt ccaccttcta attctgcatt
     6601 accaactaca gccatagcat gtcctgcatg aataccgtct gttgattcta cacgacttcc
     6661 taaaatagca atgcctttat tattagtagt caatttatca acttcattat aagatggcat
     6721 tctattaaga tattgagtat ctctaccctg tgatttccca tacttcatca tttcttgagg
     6781 tgttaaacct gtaaattgga aatcatcacc ttgtaaattc ggatgtaaat atctcattac
     6841 tgcctcagca ttataacgat ctgtattata agttgcattc agtaatgctg acattgtata
     6901 tccagcacac caaccattat taccttgtgt ttctctgatt ttaaagtttt ttaattgatt
     6961 gacatattgt gctcggactc catatttggg attctcaaat tgtataatag gttttgtaac
     7021 tgaagctgtt tgtttaaagt tttttaaatc aatatttttg ggggattcca tcgtattttt
     7081 agaattcttt tcaccactat atggagtttt taatacatgt ttaattttat tatcttctgt
     7141 aactacaaaa taaccttttg tattggttaa aattgtgaat ttctgatttt catactgatt
     7201 taatattttt gaaagaaacg gagaaacatt aattgtataa tcactatttg aacttgtatt
     7261 tttatcgttt gcaattttag gagagattgt aacaacatat actactttac cttctttatt
     7321 taacacaggg aaatagtaat taccatcact cttctgattg aatttataaa ttttaaatgc
     7381 ttcacctaat gtgtaagatg aatttttttc tccggataat ttgtcaagtg ctgctacacg
     7441 tgaaagatat tgatcttcag ctagcttttt aactgccgat ggaatatctt ttttatcaat
     7501 attaactttt gtattttttt gatttggtag ttctttttgt gatgcttcct cagcattcac
     7561 attattaaaa aacagactaa ataccaaact aagtattaaa ccaattgcaa gaacaaagac
     7621 aatcgtacta atgttacata tttttttagc catagaaaac actccttttt atttttgtaa
     7681 ctctttcatt attaatataa cactctttct gcttttttat tatttttttc ctaaatgttt
     7741 atattaacga catatttgta taaaatatta attgataacg aaaatatttt tattaactta
     7801 atacctcaat aatcttattg aataaattta ttgaggtgta caatgacagt tggggctaag
     7861 tttaaacact ttaattaagt tagacattga ccctctgcat caatacacta tttataatag
     7921 ttttattatt tttttcttct aaatttgata taaaattagt attatattct taaaattacg
     7981 gataattttt ttgacgatat acttattatc tattgctttt aatatttcag atatatcacg
     8041 ataattcaat gcgtacctta agtattagcc tacgcctata gtgatgacat tcttatcgaa
     8101 ttatttatac ttcgaaagat taaatatttt ttaagatttt agattatcaa attaagctgg
     8161 acagtttatc atcttcgatg aaactcataa atacttccaa tggtgttcta taacctaaag
     8221 attttctagg acgatgattg attttttgag caacactgat gatatgattg tctgttacta
     8281 aattgaaatc tagttcttta tctaatccac tgcgtctaag tattccgtta gaatgttcat
     8341 ttaagcctct ctgtgatggc gtgcctggat cagcaaaaaa tatagatata tcatgacagt
     8401 tgcatattgt tttccagttt gaaaactcct taccacaatc aaaagtaatt gatttaaata
     8461 tatgagaagg taaagctgaa aacattgagt gcagagcatt ttcggttctg ttgcaaagtt
     8521 aaatttatag tataatttta actttgcaac agaaccggat ttactaattg aatggtgtaa
     8581 atatcaagat gaagatgttt atgaacgcta taaaaatcat gaattaccag ggcaaaaaat
     8641 aatatttgca aaaaatatat attctagctg ctacaaaata acaaaaaaga gtgcgttctt
     8701 attaaagaat gcactcttta aacttctcta tattagaatt aaagaactta aaaataatga
     8761 tttgaaaact aattggtcta tgataatgag ataatttctt ttgtaaaatc aaatctgaac
     8821 atctaaaaaa ctaaaccact tctattaata attatttttc tctaaaaatt cttgtaaaac
     8881 tttatctgat attgccttta tggacgtgtc tttgtctaac gccatttgac taagtcttct
     8941 ttttatcaga gtatcaactc tcatagtcga acttttagcc attggcttat aattttctgt
     9001 atacttcact gctgaagtgt ctatgtcatc taaaaatcct cttttctgtt gtcctacgac
     9061 tttaatatta tctaaaaatc ctgccattgc aatcacctat ccttctatta attctattct
     9121 ttcaatcaat tctttatata tcgcttctaa catatgcaaa actcttttat catgaacatc
     9181 tttatcccta ataccttctg caccgaattt cttaattctt tctctttgaa atatttgatt
     9241 tttaaacaga gcatttgaaa aagtcttttt agatatttcc aatatatatt catcaatatt
     9301 accatttttc ttgattaata caggtatcgc acctattaat tcaaacggta aatttgattc
     9361 tttttttcta tctcttaaaa aattaacaaa tgataaactg ctttcatacg ctgattgttg
     9421 tgtctggaat accatagcaa tgtagtcgct tgcatataca gcattatttg taaaatctga
     9481 atttatcgtt ggtggtacat ctataaaaat gtagtcaaaa ttataatttt ttttaatttg
     9541 atcaataacc gttttaagta tatatcgctt ttttataata tctgtttttg caataatatc
     9601 tgacaaatta gctagtgaag aatctgcagg taataaagat aatttcgttg ataaatttat
     9661 aatactatct tctaattccc ctgttttaag agcatctata aatgtttgtt tttcatctat
     9721 tgcttctgga tatgttcttt tcataatttg ggtagcgttc ccctgaggat caaaatcaac
     9781 taatagaatt cttttatcat acctttcaga gccaatatat gataataaag ttgatacagt
     9841 agtttttcct acccctcctt taaaattacc aatagttata actgacatat acaacactcc
     9901 ttactgttat aatataatat attataacag taacttgtga catgtcacaa gttactgtta
     9961 tacaattcca aaaaatcaac tctaacaaaa acaaataagg aaagaggttt ttttattatg
    10021 tctcaatcac tacgttttac aaaactatac aaatttttat ttgaagatcc tacatttaaa
    10081 actttaccag cgaaagccaa attgctctat gcattaattt ctgagcgtca aagcttatcg
    10141 aaagctaatg ctaagcaaca tggcattcaa tcccaattta tcgataatga ggggcgtttg
    10201 ttctccattt atacgaatca agaactgatg acgaaactta atatgtcgaa accaacggta
    10261 atcaaactaa aaaaacaatt gattgaattt ggtttattag aagacgtgcg tctcggtaac
    10321 aatcaaccga atcgtttata tcccaaaaag ccctatgata actatttcta tgcctatgat
    10381 gttgacgaat tttatcgtct tcctcatgct ttatttgaaa atcccaaata tcaatcttta
    10441 gcggctgaat ctatcattgc ttatgcgatt tatctgagtc gttatgagta tagtatctat
    10501 aaaaatcatt tctcggatga aaatggtgca gtctattgtt gtttctctaa tgacaatatg
    10561 gcaaacattt tagatgtgag tacacgaaaa gtagaacgta tcaaaaaaga attgattgtt
    10621 tcgagtctaa tgattaataa gcgtgcatct tttggtaaat cgaatagatt atatatttca
    10681 ctccctaaag ctagtgatga caaggaagtt aaaaaatgtc gcactagtta tacttatttt
    10741 agttatactt attctagtga tattgattct aatgatatga atgatacgta tgataataat
    10801 attgatgaag tacatgaaat aaatgattca ccacaaacaa atcattcaag tcatccaaat
    10861 catcaacaca acacagagga tacgtttaac gatcaacaag tcgaacaaga gatgttactt
    10921 caacacttac cagactatgt acaattgaac ttaaaacatt ttagtaatac tgaaattcgt
    10981 tgtattaaat ctgtactgaa taaagcgaaa gccagttata atcaccacgc acctgtagat
    11041 gaacgtgtta cgtatgaagc ctgtacctat gctattgggg aagctttacg acgtatcaaa
    11101 ctattaagcc gacaaaaaaa tgaaaatatc tgcgatctag aagcctacat gatgcaaaca
    11161 tttaagcgtg tctttgttga acatgtgctg aacgaccaac agaaacttga cgatactaaa
    11221 acaaaaacgc atgatatttc acaatttgaa ccgaaaaatg cgttccaatc gatggcaaaa
    11281 cgtatgtttc ttgatgtttg ataactttaa tatttaggaa ggagagatag ttgtgaatga
    11341 aaaagagata gggattgcgt ttttgaacca ctttacgcaa gtggaggctt atttagaggc
    11401 tttaggtgtg cccgaaaacc atatcgcaga tattaagccg atagtcattc agaactatcc
    11461 ctatgaacgc tttttgtttg atgatttagg cgatgtaacg aatgtgatca ttcccttttc
    11521 taaagtcatt gggagtaact tatttgggaa tattggctac aagtagtttg acttagtgaa
    11581 atggtcgcta gaacagaact ttcatggtaa cgcgcctaac cttaaacccc aaaaaataca
    11641 aggctgttta ggttttctaa aatcgttagg ttgggaaaat tggaatcaaa gttatcaaac
    11701 attggatatt ggagaactct attttagttt gctacttgat gacaaagggc atgtgataac
    11761 ctatatgcat gaaggtggca atggcggcgg tagacatcga atatttactg gtaaagtctg
    11821 tggtgcagaa tatgtcagag ctgcgagatt gacacaattt agattaaata aacaaaaatt
    11881 ggcatattat aaaaataatt ggtacttgag caacaaatta aagatattat ttaaaaaggt
    11941 gaattgtttc aaattgtttg tttcgtatat tttatttatg ttttgaaagg agtatctttt
    12001 catgaaaaaa atattattat tagtgagcac atgtttatta tatttagatt gtcaaattaa
    12061 gctggacagt ttatcatcgg ttctgttgca aagttagaaa aacatctaat ttcctttttt
    12121 atcatttcag tgttagttta actagctaac atatgactga tttcgtagca tggcgaaaat
    12181 ccatagatct gaagagacct acggttcttt ttatataatc cgtaaataca ttcaatgcct
    12241 ttgagtgtat tttttgccgt attgagactt tgataccttg tctttcgtac cttaatatga
    12301 cgatgatctt gttcaatgag gttattgaga tatttagatg tgcaatgaca gttagggttc
    12361 agcttaaaca ctttcactat tttagtcatt gcaaccttcg ttgaaggtgc ttgatctgta
    12421 attatcattt gaggtttacc gaattgttta ataagacgct taataaacgc atatgctgat
    12481 tgatgatctc gttttttacg caaccaaatg tctaatgtat gtccttctgc atcaatggca
    12541 cgatataaat agttccattt tccttttatt ttgatatacg tctcatcaat acgccatttg
    12601 taataagctt ttttatgctt tttcttccaa atctgataca caatcggtgc atattcttga
    12661 acccaacgat agactgttga atgatgaaca ttgacaccac gttcccttaa tatttcagat
    12721 atgtcacgat aactcaatgc atatcttaga tagtagccaa cggctacagt gataacaccc
    12781 ttgttaaatt gtttatatct gaaatagttc atacagaaga ctcctttttg ttaaaattat
    12841 actatcaatt caactttgca acagaaccct agcaagttaa tacgaagtat tattttaaac
    12901 atgagtctag aggtttattt tttaactttg caacataact gttttagata tatgtgtagg
    12961 agtaaaactt ttttgcgaag aataagtata taaataaatt ggagataagt ataattacat
    13021 tgacgtttat aggaaatgta gttattttgg ttccatttgt acttgtagcg ataagtgaga
    13081 atggtaatag tagtggagaa gataatgatt ttaataggta tggttgtatg attttaaaat
    13141 attagctatc aaaaaatatt tttatagaga aaataataaa aaacatctag atcagtttgt
    13201 accttgaaat ttgaaatcaa taaaaaaacg accactaaca cctcatagct attatactac
    13261 aaatattgtg gtcgttctga agacttcatt catttggagg tgaggcataa gtactcgtgg
    13321 gggatatcct aacctctctt ttttgaattg tgtattttga tgttgataat aaactaaaat
    13381 actgctgttt ttattgtaaa aaccaaatag caatttgagc tactaaatta tttagtacat
    13441 ggatagagag tatataataa aagttgtgtt tttttaaata aataaaaact gttactatgc
    13501 ctattgaaaa ataggggatt aatgtcttcc aatcttctgt taaactatgc atatgtatta
    13561 ccgtaaaaga cgatatagaa attaatattg cagggagtaa tttaattttg tttttaagaa
    13621 cttctaaaat atatactctg aaaagtaatt cttcaagtat aggtccaatg ataacaatta
    13681 ataatggtgc aaaaaattga gataaaaatg aaatattttc aatggcattt tggttaacac
    13741 tctttactgg tctgccttga ttaataatta atataagtat tacatttaaa agaagaatta
    13801 gaaaaaagcc tactattcct gtaagaaaga caccaatttt tttgttttta atatttaacc
    13861 aatctttctg tagttttact ttaaatattt taatggcata tatcatcaaa atagttgtaa
    13921 taacaaaaaa ataccattca ttaattatat cgtaatttat atttagtttg tttgaaaacg
    13981 gtaatattgc gtatctgggg ataatgatga gtagtattat ataaattaaa gctaaatagt
    14041 gactttggtg aatgttattt aaatttttgt acatggaaat ctcctgaatt ttttataatt
    14101 actaagtatt tgtttaaaag ttatttggat ttgctttgta ttcccatttt aagaagcaaa
    14161 gaagtttata aaggtataat aaatactata ttttgccctg ttacgaaatt aaatctatag
    14221 tatactttta gctttgcaac aaaatccttt ataacgttgg cttaagataa gtttttatcg
    14281 cttttaatat atcatttttt aaattgtcct gtagttcgtc tttatagttg tattgacgtg
    14341 cttttaggtc taaagcgcgt atttgaacag tgtctatcac accagatact aatccttttt
    14401 ttgttttaag ttggatatct gttggataac gtaaaccccg agttgttatg ggtaaaaccc
    14461 aaacaaaatt agtgccatca atactcatct gattatttat cactaagcag ggccttacgt
    14521 tatgcttttc acgtccacga gttggattta aatcaatgta gagtatgtca aattgtttaa
    14581 tgttcatatt tctcggccaa ctctttcttc ccaatctact tctaattctg tatactttcc
    14641 accactttga aagaaatttt taattctatc ttcaatagac tccttttttt tagtaatgaa
    14701 caaaccacca ttcatttttt gaacttcaac tgtatctcct atatcaaaat tagctaacct
    14761 gatagttttt ttacttaaac tgattgcttt actgtttcca tttttaaaaa ctcgttccga
    14821 agtcttgttt aagtctttta atgatttagc cattattatc agcccccttt tgttcatcat
    14881 aacaaatgta gttaccaaag taaatacata tgaagttgaa taatttataa aaatcaaaaa
    14941 catcgctttt actatcctcg actgcatttt ttacaaaggt gaaaagtaaa tatttaattt
    15001 ttcgtttaag gtaatcgttt tcttaacttt ctagtatgac gataattttg ctcaatgagt
    15061 tcgttaaggt atttatattt ataatgacag ttaatattaa ggttaatatc ttgaattaat
    15121 tcggacattg cccttcttat ttaattttga tatatatctt atcaacatac agtttaaagt
    15181 taaccctaag ttctctttcc atatatcaca ataactcaac gtctatctta atcaacaatc
    15241 atcaactata tcgttgctac ctttatcaaa ttgtttatag ctgcagtagt tcatgtagaa
    15301 tatttctttg tgttaatacc ataccataaa attaactttg caatagaatc tatatttata
    15361 attattttac ccatttatgt taattaatgg taaaataatt ataaatatag agaggttaaa
    15421 agaatgaact atataaaata tatacatagt gtagatggaa caactttata tgttaaagtg
    15481 aatgaaaatg taaatagtag cgctaatatc attatatgtc atggattagc agagcattta
    15541 gatcgctatg acgaaatttc aaactatttg caggagaaaa attttaatat tataagattt
    15601 gatcaacgag gacatggaag gtctggagga aaacgaactt tttatagcaa tgtaaatgag
    15661 atagttgagg acttagatgc tgttattaat ttcaccaaag aacattataa aggtaatatc
    15721 tatctgattg ggcatagtat gggaggatat gggtctgtac tttattctac taaaaaccct
    15781 ggaaagatta atggtttaat tatatctgga gcagtaacaa ggtataatca gaaaactttt
    15841 ggagacattg atgatacaat tgatagaaat aagtatatta attatgaaat tggagaggga
    15901 gtgtgtagtg atacttttga gttagaaaaa tatagattag atgcattaac tgaaaaaaag
    15961 gtatcttacg gcttgatata cactgttttg gaaggtgtaa aaggcttagt ggaaaatgct
    16021 caatattttg atgataatat tttaatttta catggcaaag atgatgggtt ggttcattac
    16081 agtgactctt tagattttta taaaaacatt tcttcttcaa aaaaagaatt acatatttat
    16141 gatggtttac aacacgaaat ttttaacgag agaaaaaaga ataaagaaat tttttcggag
    16201 attgcaaact ggataaataa tgatttaact tgagaatccg attgataaat ttgaataagt
    16261 cggttctgtt gcaaagttta aaaataagtg tccagcttta tctttaaaag ttttacttca
    16321 gaagaaatta gaaaggatta ttttgatgaa aaaaacaaca atatattttg ttctatattt
    16381 tattataagc gctcttggtt ttggtatgtt gaaaaaatta gggatagaat ataatagttt
    16441 ggaaattgca gtatatgccc ttcctatgat gataattttg tcaatatttg tttactcaat
    16501 agctttgaat ccctatcaaa aaagaaaaag ttctcctata atacatgtaa aatcattgga
    16561 atatgtggtt ccattggtta tattatgtga tatattaata attttagaat tattatatac
    16621 tggtaatttt agacccatat tagtggcaca gttattttta acctttctta ttggtttttc
    16681 agaagaattc ttctttagaa aatatattat tgaacatata ttgactaaat acaaatcaaa
    16741 actgttagcc cttattactt cttctatact ttttggttta ctacatatgg caaatacctt
    16801 tggtggctta actattgaaa atgctgcttc tcaatctatg tcagctacag gagtaggatt
    16861 attatatggt ttaatatata tattcacaaa aaaaatatgg atgttggtat tattgcacat
    16921 gaacgttgat ttcgctttat tttcgtctgt aataaatcaa tcatatttac aagcagtacc
    16981 agcctttatt gtggatatta ttttaatttt tactgtttta aagataatta tgtatatact
    17041 caagtcaatt aaatctaaaa ataataagtt tttatagagg atacatagaa atattacggt
    17101 tctgttgcaa agttaaaaat catataatat aaatacagag aaatgagaaa ataaccaaat
    17161 ctcccgaaat aatctattgt tattgcagca ttttgtttat tgattttgta tagatttgta
    17221 tactaattta actttgcaac agaaccctta ttgttg
//
