LOCUS       NC_013367               8140 bp    DNA     circular CON 07-APR-2024
DEFINITION  Escherichia coli O111:H- str. 11128 plasmid pO111_4, complete
            sequence.
ACCESSION   NC_013367
VERSION     NC_013367.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMD00060957
            Assembly: GCF_000010765.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli O111:H- str. 11128
  ORGANISM  Escherichia coli O111:H- str. 11128
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1
  AUTHORS   Ogura,Y., Ooka,T., Iguchi,A., Toh,H., Asadulghani,M., Oshima,K.,
            Kodama,T., Abe,H., Nakayama,K., Kurokawa,K., Tobe,T., Hattori,M. and
            Hayashi,T.
  TITLE     Comparative genomics reveal the mechanism of the parallel evolution
            of O157 and non-O157 enterohemorrhagic Escherichia coli
  JOURNAL   Proc Natl Acad Sci U S A 106 (42), 17939-17944 (2009)
   PUBMED   19815525
REFERENCE   2  (bases 1 to 8140)
  AUTHORS   Hattori,M., Toh,H., Oshima,K., Yamashita,A., Hayashi,T., Ogura,Y.
            and Ooka,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-DEC-2008) Contact:Masahira Hattori University of
            Tokyo, Graduate School of Frontier Sciences; 5-1-5 Kashiwanoha,
            Kashiwa, Chiba 277-8562, Japan URL
            :http://www.cb.k.u-tokyo.ac.jp/hattorilab/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000010765.1-RS_2024_04_07
            Annotation Date                   :: 04/07/2024 09:09:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,896
            CDSs (total)                      :: 5,750
            Genes (coding)                    :: 5,390
            CDSs (with protein)               :: 5,390
            Genes (RNA)                       :: 146
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 111
            ncRNAs                            :: 13
            Pseudo Genes (total)              :: 360
            CDSs (without protein)            :: 360
            Pseudo Genes (ambiguous residues) :: 0 of 360
            Pseudo Genes (frameshifted)       :: 138 of 360
            Pseudo Genes (incomplete)         :: 210 of 360
            Pseudo Genes (internal stop)      :: 77 of 360
            Pseudo Genes (multiple problems)  :: 58 of 360
            Pseudo Genes (short protein)      :: 3 of 360
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP010964.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..8140
                     /organism="Escherichia coli O111:H- str. 11128"
                     /mol_type="genomic DNA"
                     /strain="11128"
                     /serovar="O111:H-"
                     /db_xref="taxon:585396"
                     /plasmid="pO111_4"
                     /note="enteropathogenic Escherichia coli"
     gene            1..915
                     /locus_tag="ECO111_RS30075"
                     /old_locus_tag="ECO111_p4-01"
     CDS             1..915
                     /locus_tag="ECO111_RS30075"
                     /old_locus_tag="ECO111_p4-01"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001738986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_001277132.1"
                     /translation="MSAVLQRFREKLPHKPYCTNDFAYGVRILPKNIAILARFIQQNQP
                     HALYWLPFDVDRTGASIDWSDRNCPAPNITVKNPRNGHAHLLYALALPVRTAPDASASA
                     LRYAAAIERALCEKLGADVNYSGLICKNPCHPEWQEVEWREEPYTLDELADYLDLSASA
                     RRSVDKNYGLGRNCYLFEKGRKWAYRAIRQGWPAFSQWLDAVIQRVEMYNASLPVPLSP
                     PECRAIGKSIAKYTHRNFTPETFAQYVADTHTPEIQATRGRKGGSKSKRGTVATSARTL
                     KPWEKLGISRAWYYQLKKRGLVE"
                     /name="replication initiation protein"
     gene            complement(1132..1407)
                     /locus_tag="ECO111_RS30080"
                     /old_locus_tag="ECO111_p4-02"
     CDS             complement(1132..1407)
                     /locus_tag="ECO111_RS30080"
                     /old_locus_tag="ECO111_p4-02"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000091757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000091754.1"
                     /translation="MSRTLEQKIAEAEARLQRLKAKSRSLDTAQKVIVGAAMLARVRRP
                     EEAQLRAFLLQFLRKEVTRQADVNRLQPLINEPEKLPRPPAKPQNH"
                     /name="hypothetical protein"
     gene            1586..3805
                     /gene="mobQ"
                     /locus_tag="ECO111_RS30085"
                     /old_locus_tag="ECO111_p4-03"
     CDS             1586..3805
                     /gene="mobQ"
                     /locus_tag="ECO111_RS30085"
                     /old_locus_tag="ECO111_p4-03"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001029330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobQ family relaxase"
                     /protein_id="WP_001029340.1"
                     /translation="MAIYHLSMKIISRKNGYSAVASAAYRSGSVIPDDRTGLTHDYTRK
                     RGVDDAVILTPANAPSWCGDRSVLWNAVEKAEQRRNSQLAREIELAIPREISREAARET
                     VLAFVRENFVSRGMIADVAFHHMDRTNPHAHIMLTTRAVGETGFAGKVRDWNDRALAET
                     WRASWADHANRALANAGYQEEIDHRSYERQGLEKAPGLHLGKAACAMEKRGMETERGEQ
                     NRLINSLNLEIQVSRTRLAVIQVQENVRKRELSDAARRAAEALNLTIPAANASADTLRE
                     FIATLPQECGNAWEMTPEFLAMSGKVNDIEREGNALLKEQAILEKEMTGLKKARPVASL
                     LSEIPLMTWAEPEYRKRQLRFWKLGKQIESLRRTYRAVKERDIPARRQAFETQWNTWIA
                     PGMAELKEKLSAREAERRREEAEAEARRKEQEHEARLKRHDNHRLSRETALVGVITELG
                     RAREPGTGRITRYMMLSNRAGEFTVWGDELAHYPQSVHDPVNVYLSPGGAVMVSDIREG
                     MPESHETMARPERVRMYSGATVRHVLEQMRQGWPSYGFPALPHHWPDNFYFSDDRRPVA
                     SPLPSAHRVDITADAVPEQLMPVVFSREGNSRTLNLLLCKGPEEMLVGFVRREGGFCPV
                     LVLPSPDYSHLIVSTITENGVCLAGYGEAINHDEDTPYPPEPHLMQFRLKGHHDRLLAA
                     VHKPEEMPDYLFRQLGFNQTWHEWKRDEQHRQQQRRPGHFRGMSM"
                     /name="mobQ"
     gene            4038..5783
                     /gene="col"
                     /locus_tag="ECO111_RS30090"
                     /old_locus_tag="ECO111_p4-04"
     CDS             4038..5783
                     /gene="col"
                     /locus_tag="ECO111_RS30090"
                     /old_locus_tag="ECO111_p4-04"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_172690082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-E2"
                     /protein_id="WP_000012960.1"
                     /translation="MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNP
                     WGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLA
                     VSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADD
                     ITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTA
                     SIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHN
                     AVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARN
                     QERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFDRFAHDPMSGGHRMWQMAGLKAQR
                     AQTDVNNKQAAFDAAAKEKSDADAALSAAQERRKQKENKEKDAKDKLDKESKRNKPGKA
                     TGKGKPVGDKWLDDAGKDSGAPIPDRIADKLRDKEFKNFDDFRRKFWEEVSKDPELSKQ
                     FNPGNKKRLSQGLAPRARNKDTVGGRRSFELHHDKPISQDGGVYDMDNLRITTPKRHID
                     IHRGQ"
                     /name="col"
     gene            5786..6043
                     /locus_tag="ECO111_RS30095"
                     /old_locus_tag="ECO111_p4-05"
     CDS             5786..6043
                     /locus_tag="ECO111_RS30095"
                     /old_locus_tag="ECO111_p4-05"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000421100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="WP_000421100.1"
                     /translation="MELKNSISDYTETEFKKIIEDIINCEGDEKKQDDNLEHFISVTEH
                     PSGSDLIYYPEGNNDGSPEAVIKEIKEWRAANGKSGFKQG"
                     /name="bacteriocin immunity protein"
     gene            6105..6248
                     /locus_tag="ECO111_RS30100"
                     /old_locus_tag="ECO111_p4-06"
     CDS             6105..6248
                     /locus_tag="ECO111_RS30100"
                     /old_locus_tag="ECO111_p4-06"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724569.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_001314446.1"
                     /translation="MKKITGIILLLLAVIILAACQANYIRDVQGGTVSPSSTAEVTGLA
                     TQ"
                     /name="colicin release lysis protein"
     gene            6714..6854
                     /locus_tag="ECO111_RS32830"
     CDS             6714..6854
                     /locus_tag="ECO111_RS32830"
                     /inference="COORDINATES: protein motif:HMM:NF020569.4"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]; GO:0043022 - ribosome binding
                     [Evidence IEA]; GO:0003723 - RNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E3/pyocin S6 family cytotoxin"
                     /protein_id="WP_231237649.1"
                     /translation="MYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKY
                     L"
                     /name="colicin E3/pyocin S6 family cytotoxin"
     gene            6864..7121
                     /locus_tag="ECO111_RS30110"
                     /old_locus_tag="ECO111_p4-09"
     CDS             6864..7121
                     /locus_tag="ECO111_RS30110"
                     /old_locus_tag="ECO111_p4-09"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /GO_function="GO:0015643 - toxic substance binding
                     [Evidence IEA]"
                     /GO_process="GO:0030153 - bacteriocin immunity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E3-like toxin immunity protein"
                     /protein_id="WP_000523347.1"
                     /translation="MGLKLHINWFDKTTEEFKGGEYSKDFGDDGSVIERLGMPLKDNIN
                     NGWFDVIAEWVPLLQPYFNHQIDISGNEYFVSFDYRDGDW"
                     /name="colicin E3-like toxin immunity protein"
     gene            7141..7407
                     /locus_tag="ECO111_RS30115"
                     /old_locus_tag="ECO111_p4-10"
     CDS             7141..7407
                     /locus_tag="ECO111_RS30115"
                     /old_locus_tag="ECO111_p4-10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000861936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="WP_000861935.1"
                     /translation="MKVELKKRISDYTEAEFLELVKKICRAEGATEEDDNKLVREFERL
                     TEHPDGSDLIYYPRDDREDSPEGIVKEIKEWRAANGKSGFKQG"
                     /name="bacteriocin immunity protein"
     gene            7469..7612
                     /locus_tag="ECO111_RS30120"
     CDS             7469..7612
                     /locus_tag="ECO111_RS30120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724569.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_000724382.1"
                     /translation="MKKITGIILLLLAVIILAACQANYIRDVQGWTVSPSSTAELTGLA
                     TQ"
                     /name="colicin release lysis protein"
     BGC             1..8140
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(1412..1585)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="2.5600000000000002e-86"
     Typing          complement(1586..1944)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="99.444"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          2..915
                     /name="rep_cluster_2134"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          1587..3802
                     /name="MOBQ"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="99.053"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 atgagcgccg tacttcaacg cttcagggaa aaattaccgc acaaaccgta ctgtacgaac
       61 gatttcgcgt acggcgttcg cattctgccg aaaaacattg ccattcttgc ccgtttcatc
      121 cagcagaacc agccacatgc actgtactgg cttccctttg acgtggaccg gacgggggca
      181 tcaatcgact ggagcgaccg gaattgtccg gccccgaaca tcaccgtaaa aaatccccgt
      241 aacgggcacg cgcatctgct ctacgcgctc gcccttcctg tgagaactgc gccggatgca
      301 tcggcttcgg cgctcagata cgctgccgct attgagcgtg cgttgtgtga aaaactgggc
      361 gcggatgtga attacagcgg cctgatctgc aaaaatccgt gccaccctga atggcaggaa
      421 gtggaatggc gcgaggaacc ctacactctc gacgaactgg ctgattatct cgatttgagc
      481 gcctcagcgc gccgtagcgt cgataaaaat tacgggctgg ggcgaaactg ctatctgttc
      541 gaaaagggcc gtaaatgggc ttaccgggct attcgtcagg gctggccggc attctcacaa
      601 tggcttgatg cggtgattca gcgtgtcgaa atgtacaacg catcgctccc cgttccgctt
      661 tcacctcctg aatgtcgggc tattggcaag agtattgcga aatacacgca caggaacttc
      721 acgccggaaa ctttcgcaca gtatgtggct gatacgcaca cgccagaaat tcaggctaca
      781 cgcggtcgca agggcggttc taagtctaag cgcggcacag tagctacatc agcacgcacg
      841 ctgaaacctt gggagaaatt agggatcagt cgcgcctggt attaccaact gaaaaaacga
      901 ggtctcgtag agtagaccaa ataagcctat atcagataac agcgcctttt tggcgtcttt
      961 tcgagcagct tggtttgttg ctatttccct cgttgaatcc cgcaatggtg tggctttccg
     1021 catgattgag gtggtagcgc tcgccgcagt ctcatgtccg agcgtagcga gcgaatgagc
     1081 gaggaagcgc aaaggcgtcc ggtggtgcat gtggcactta cgcgccgggg cttagtggtt
     1141 ctgcggtttc gccggtggtc tgggtagctt ctccggctcg ttaatcagcg gttgtagtcg
     1201 gttcacatcc gcctgtcttg tgacttcctt tcgcagaaac tggagcagga acgcacgcag
     1261 ttgcgcttct tccggcctcc gtacccttgc cagcatggct gcccccacaa tgactttttg
     1321 cgccgtgtcc aggcttcggc tcttcgcctt caggcgctgt aatctggcct cagcttcggc
     1381 aatcttctgt tcgagtgttc tgctcatttc gtgactccgt gcgcggtgaa aaatcgcatt
     1441 ttagcgcgtc actggtagtt gcaaaactga actggcataa tgcacggcac atcacgaagt
     1501 gcgcacttat acaatctcca cttcgtttcg attgtgtgcg gtctgcgacg ctaaaagaaa
     1561 acggcaaaaa ggcattacgg cagaaatggc gatttatcat ctcagcatga aaatcatttc
     1621 gcgaaaaaac ggctacagtg ccgttgcttc tgctgcctac cgttccggct ctgtcatacc
     1681 cgatgaccgt accggattaa cccacgatta cacccgtaaa cgcggcgttg atgatgcggt
     1741 cattctcacc cctgcgaatg caccgtcctg gtgtggtgac cgttccgttc tctggaatgc
     1801 ggtcgagaaa gccgaacagc gccggaactc ccagctggca agggagattg aactcgccat
     1861 tccccgtgag atttcccgcg aggccgcacg ggagaccgtt ctcgcttttg tccgggaaaa
     1921 ctttgtcagt cggggcatga ttgccgatgt ggcgttccat cacatggacc ggaccaatcc
     1981 ccatgcgcac atcatgctga ccacgagagc tgtcggggaa acgggatttg caggaaaggt
     2041 cagggactgg aacgaccggg cactcgccga gacgtggcgc gcatcatggg ctgaccatgc
     2101 gaacagagcg cttgcgaacg ccggctacca ggaagagata gaccatcgtt catacgagcg
     2161 tcagggactg gagaaagcgc ccggccttca cctcggaaag gctgcctgtg cgatggaaaa
     2221 acggggaatg gaaacagaac gcggtgagca gaaccgtctg attaacagcc ttaacctgga
     2281 aatacaggtt tcccgcacaa ggctggcagt catccaggta caggagaacg tgcggaaacg
     2341 ggaactcagc gatgccgcac gtcgtgcagc ggaagccctt aacctgacca ttcccgctgc
     2401 gaatgcctca gcggataccc tgcgggaatt cattgccacg ttgccgcagg aatgcggcaa
     2461 cgcgtgggag atgaccccgg agttcctggc gatgagcggg aaggtgaacg acatcgaacg
     2521 tgaggggaat gcgctgctga aagagcaggc cattctcgaa aaggagatga ccggactcaa
     2581 aaaagcacgc cctgtcgcgt cccttctgtc agagattccc ctgatgacat gggctgaacc
     2641 ggaataccgc aaaagacaac tccgtttctg gaaactcggg aaacagattg aatctcttcg
     2701 ccgcacctac agggccgtga aagaacggga cattcccgcc cgtcgtcagg cctttgaaac
     2761 gcagtggaat acgtggattg cgccgggaat ggcagagctg aaagaaaaac tgtcagcacg
     2821 ggaagcggag cggcgcaggg aggaagccga agcggaagcg cgccggaagg aacaggagca
     2881 tgaggcgcgg ctgaaacgtc atgataacca ccgtctgagc cgtgaaacgg cattagtcgg
     2941 ggttattacg gagctggggc gtgccagaga gccgggaacg ggcaggataa cccgctacat
     3001 gatgctgagt aacagagccg gagaattcac ggtatggggt gatgagctgg cgcattaccc
     3061 ccagagtgtt catgacccgg tgaatgttta cctgtcgcca ggcggggctg tgatggtctc
     3121 ggatatacgt gagggaatgc cagaatctca tgagacgatg gcgcggcctg agcgtgtgag
     3181 aatgtattcc ggtgcgacgg tccggcatgt actggaacag atgcgccagg ggtggccctc
     3241 ttacggtttt ccggcgctgc cgcatcactg gccggataat ttttatttca gcgacgaccg
     3301 caggcccgta gcctctccgc tgccgtcagc gcaccgggtg gatatcaccg ctgatgctgt
     3361 accggaacaa ctcatgcctg ttgtattttc gagagaggga aacagcagga cgctgaatct
     3421 gttgttatgc aaagggccgg aggaaatgct tgtcgggttt gttcgccggg aaggagggtt
     3481 ttgccccgtt cttgtgcttc cgtcgccgga ttacagtcat ctgatagtca gcaccatcac
     3541 ggagaacggg gtatgcctgg caggttacgg agaagctata aaccatgatg aggatactcc
     3601 gtacccaccg gaaccgcacc tgatgcagtt ccggctcaaa ggccatcatg acaggctttt
     3661 ggctgctgtc cacaaaccgg aagagatgcc ggattatctc ttccgtcaac tcggttttaa
     3721 tcagacctgg catgagtgga agcgggacga acagcacagg caacaacaac gccgccccgg
     3781 gcacttccgg ggcatgagta tgtgatgtcc ggggctgcac cccggacccc gccaacacat
     3841 cacgggccac aaaatttttt gtggcccgct ctgcgttttc taagtgttat ccctcctgat
     3901 ttctaaaaaa ttttccacct gagcttgaca gaaaaaacga tgacgggtac tttttgatct
     3961 gtacataaaa ccagtggttt tatgtacagt attaatcatg taattaattg ttttaacgct
     4021 taaaagaggg aatttttatg agcggtggcg atggacgcgg ccataacacg ggcgcgcata
     4081 gcacaagtgg taacattaat ggtggcccga ccgggcttgg tgtaggtggt ggtgcttctg
     4141 atggttccgg gtggagttcg gaaaataacc cgtggggtgg tggttccggt agcggcattc
     4201 actggggagg tggttccggt catggtaatg gcggggggaa tggtaattcc ggtggtggct
     4261 cgggaacagg cggtaatctg tcagcagtag ctgcgccagt ggcatttggt tttccggcac
     4321 tttccactcc aggagctggc ggtctggcgg tcagtatttc agcgggagca ttatcggcag
     4381 ctattgctga tattatggct gccctgaaag gaccgtttaa atttggtctt tggggggtgg
     4441 ctttatatgg tgtattgcca tcacaaatag cgaaagatga ccccaatatg atgtcaaaga
     4501 ttgtgacgtc attacccgca gatgatatta ctgaatcacc tgtcagttca ttacctctcg
     4561 ataaggcaac agtaaacgta aatgttcgtg ttgttgatga tgtaaaagac gaacgacaga
     4621 atatttcggt tgtttcaggt gttccgatga gtgttccggt ggttgatgca aaacctaccg
     4681 aacgtccggg tgtttttacg gcatcaattc caggtgcacc tgttctgaat atttcagtta
     4741 ataacagtac gccagcagta cagacattaa gcccaggtgt tacaaataat actgataagg
     4801 atgttcgccc ggcaggattt actcagggtg gtaataccag ggatgcagtt attcgattcc
     4861 cgaaggacag cggtcataat gccgtatatg tttcagtgag tgatgttctt agccctgacc
     4921 aggtaaaaca acgtcaggat gaagaaaatc gccgtcagca ggaatgggat gctacgcatc
     4981 cggttgaagc ggctgagcga aattatgaac gcgcgcgtgc agagctgaat caggcaaatg
     5041 aagatgttgc cagaaatcag gagcgacagg ctaaagctgt tcaggtttat aattcgcgta
     5101 aaagcgaact tgatgcagcg aataagactc ttgctgatgc aatagctgaa ataaaacaat
     5161 ttgatcgatt tgcccatgac ccaatgtctg gcggtcacag aatgtggcaa atggccgggc
     5221 ttaaagccca gcgggcgcag acggatgtaa ataataagca ggctgcattt gatgctgctg
     5281 caaaagagaa gtcagatgct gatgctgcat taagtgccgc gcaggagcgc cgcaaacaga
     5341 aggaaaataa agaaaaggac gctaaggata aattagataa ggagagtaaa cggaataagc
     5401 cagggaaggc gacaggtaaa ggtaaaccag ttggtgataa atggctggat gatgcaggta
     5461 aagattcagg agcgccaatt ccagatcgca ttgctgataa gttgcgtgat aaagaattta
     5521 aaaacttcga cgattttcgg agaaaattct gggaagaagt gtcgaaagat cctgagttaa
     5581 gtaagcaatt taatccaggt aataaaaaac gcttgagcca aggattagct ccacgggcta
     5641 ggaataaaga tactgtcggt gggcgtcgct catttgagct tcatcacgac aagccaatca
     5701 gtcaggatgg tggtgtttat gatatggaca acctccgtat cactacgccg aaacgccata
     5761 ttgatattca cagaggtcag taaaaatgga actgaaaaac agcattagtg attacactga
     5821 aactgaattc aaaaaaatta ttgaagacat catcaattgt gaaggtgatg aaaaaaaaca
     5881 ggatgataac ctcgagcatt ttataagtgt tactgagcat cctagtggtt ctgatctgat
     5941 ttattaccca gaaggtaata atgatggtag ccctgaagct gttattaaag agattaaaga
     6001 atggcgagct gctaacggta agtcaggatt taaacagggc tgaaatatga atgccagttg
     6061 tttaaggatg aatgactggc attctttcac aacaaggagt cgttatgaaa aaaataacag
     6121 ggattatttt attgcttctt gcagtcatta ttctggctgc atgtcaggca aactatatcc
     6181 gggatgttca gggcgggacc gtatctccgt catcaacagc tgaagtgacc ggattagcaa
     6241 cgcagtaacc cgaaatcctc tttgacaaaa acaaagcgtg tcaggctgat tctgatgcgc
     6301 tttttttgaa atgtcacaaa agttccatgt gggagatggg atctaaaatc cctgtgcaga
     6361 accttccatc cggtgggaga aaacttgtca ttttgacctg ttcgccattc gggggggggc
     6421 gcttggaaaa cggaaatttt cccacgctaa gagaattgag ttgaacgagt ggttacatct
     6481 aggccagcta actcactgaa cgtaaaggct gtacgaaatg ttccgaccgt ccgataacca
     6541 tttggcttac ttccgtacat ttccttgcgt agatgtacag aattgtacga tttcggacac
     6601 caaaaccgct gttgtcccgc cattctggcg attcctgaaa gttatttgac taaaaaatag
     6661 tcttaacgtg gtttattttc cgaattccaa gcggacccca taaaggccgt aagatttatg
     6721 aatgggactc ccagcacggt gaacttgaag ggtatcgtgc cagtgatggt cagcatcttg
     6781 gctcattcga tcctaagact ggtaatcagt tgaaaggacc tgatccaaaa cgaaatatca
     6841 aaaagtatct ttgagaggat gttatggggc ttaaattaca tattaattgg tttgataaga
     6901 cgaccgagga atttaaaggt ggtgagtatt caaaagattt cggtgatgat ggctcggtca
     6961 ttgaacgtct tggaatgcct ttaaaagata atatcaataa tggttggttt gatgttatag
     7021 ctgaatgggt acctttgcta caaccatact ttaatcatca aattgatatt tccggtaatg
     7081 agtattttgt ttcatttgat tatcgtgatg gtgattggtg atcaaatatt ctcaggagag
     7141 atgaaggtgg agctaaagaa aagaattagt gattataccg aggctgaatt tctggagctt
     7201 gtaaaaaaaa tatgtagagc tgaaggtgct actgaagagg atgacaataa attagtgaga
     7261 gagtttgagc gattaactga gcacccagat ggttcagatc tgatttatta tcctcgcgat
     7321 gacagggaag atagtcctga agggattgtc aaggaaatta aagaatggcg agctgctaac
     7381 ggtaagtcag gatttaaaca gggctgaaat atgaatgccg gttgtttaag gatgaatgac
     7441 tggcattctt tcacaacaag gagtcgttat gaaaaaaata acagggatta ttttattgct
     7501 tcttgcagtc attattctgg ctgcatgtca ggcaaactat atccgggatg ttcagggctg
     7561 gactgtatcc ccgtcatcaa cagctgaact gaccggatta gcaacgcagt aacccgaaat
     7621 cctctttgac aaaaacaaag cgtgtcaggc tgattctgat gcgctttttt ttgaaatgtc
     7681 acaaaaattc catgtgggag atgggatcta aaattctcgt gcagaacttt ccatccaggg
     7741 ggagaaaact tgtcgttttg agccgttcgg tgttcagaac gcacgaaacc gatcgtgtat
     7801 cgctttcgtg catagttatg caacgcgcta aaaacgattc tgacgcattt tttatgttta
     7861 ccctggtgtt tccttgtctt tttgtgtttt ttgcgtcaga aagcgattga gggtgtttta
     7921 aggggtacgt acaacgggag ttatggtaaa tggatcggtt tttcgggaag gatcgacagg
     7981 atttgccgtt gggtgtagtg taagcgactg aaaaacaaac gccccgtaaa tcgtgctctc
     8041 accgccaaga ttgatcacga aattacaggg cgccgggttc cgcgtttccc gatgggaaag
     8101 cgcggttagt taaactgtgt accgagagaa atcgtatcac
//
