LOCUS       NC_011382              23753 bp    DNA     circular CON 28-NOV-2023
DEFINITION  Klebsiella pneumoniae plasmid 15S, complete sequence.
ACCESSION   NC_011382
VERSION     NC_011382.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN14225334
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 23753)
  AUTHORS   Gootz,T.D., Lescoe,M.K., Dib-Hajj,F., Dougherty,B.A., He,W.,
            Della-Latta,P. and Huard,R.C.
  TITLE     Genetic organization of transposase regions surrounding blaKPC
            carbapenemase genes on plasmids from Klebsiella strains isolated in
            a New York City hospital
  JOURNAL   Antimicrob Agents Chemother 53 (5), 1998-2004 (2009)
   PUBMED   19258268
REFERENCE   2  (bases 1 to 23753)
  AUTHORS   Gootz,T.D., Lescoe,M., Dibhajj,F.B., Dougherty,B.A., He,W.,
            Della-Latta,P. and Huard,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-SEP-2008) Department of Infectious Diseases, Pfizer
            Inc., Eastern Point Road, Groton, CT 06340, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/28/2023 03:53:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 25
            CDSs (total)                      :: 25
            Genes (coding)                    :: 22
            CDSs (with protein)               :: 22
            Genes (RNA)                       :: 0
            tRNAs                             :: 0
            ncRNAs                            :: 0
            Pseudo Genes (total)              :: 3
            CDSs (without protein)            :: 3
            Pseudo Genes (ambiguous residues) :: 0 of 3
            Pseudo Genes (frameshifted)       :: 0 of 3
            Pseudo Genes (incomplete)         :: 3 of 3
            Pseudo Genes (internal stop)      :: 0 of 3
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FJ223606.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..23753
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="15"
                     /db_xref="taxon:573"
                     /plasmid="15S"
     gene            complement(466..615)
                     /locus_tag="HS642_RS00005"
                     /old_locus_tag="pKlebpneu15S_p01"
     CDS             complement(466..615)
                     /locus_tag="HS642_RS00005"
                     /old_locus_tag="pKlebpneu15S_p01"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(700..957)
                     /locus_tag="HS642_RS00010"
                     /old_locus_tag="pKlebpneu15S_p02"
     CDS             complement(700..957)
                     /locus_tag="HS642_RS00010"
                     /old_locus_tag="pKlebpneu15S_p02"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            complement(967..1788)
                     /locus_tag="HS642_RS00015"
                     /old_locus_tag="pKlebpneu15S_p03"
     CDS             complement(967..1788)
                     /locus_tag="HS642_RS00015"
                     /old_locus_tag="pKlebpneu15S_p03"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004199321.1"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]; GO:0043022 - ribosome binding
                     [Evidence IEA]; GO:0003723 - RNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E3/pyocin S6 family cytotoxin"
                     /protein_id="WP_004199321.1"
                     /translation="MSFRSTERQTPTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDK
                     AKAELDAEDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEY
                     GSGWQDQVRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKD
                     AENKLNEEKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYG
                     DKKRKIYEWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin E3/pyocin S6 family cytotoxin"
     gene            complement(1904..>2074)
                     /locus_tag="HS642_RS00020"
                     /pseudo=""
     CDS             complement(1904..>2074)
                     /locus_tag="HS642_RS00020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032489893.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydrolase"
                     /name="serine hydrolase"
     gene            complement(2129..2833)
                     /locus_tag="HS642_RS00025"
                     /old_locus_tag="pKlebpneu15S_p04"
     CDS             complement(2129..2833)
                     /locus_tag="HS642_RS00025"
                     /old_locus_tag="pKlebpneu15S_p04"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221000.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS26 family transposase"
                     /protein_id="WP_001067855.1"
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="IS6-like element IS26 family transposase"
     gene            complement(<2899..3114)
                     /locus_tag="HS642_RS00030"
                     /pseudo=""
     CDS             complement(<2899..3114)
                     /locus_tag="HS642_RS00030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001424636.1"
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase domain-containing protein"
                     /name="nucleotidyltransferase domain-containing protein"
     gene            complement(3184..3738)
                     /gene="aac(6')-Ib"
                     /locus_tag="HS642_RS00035"
                     /old_locus_tag="pKlebpneu15S_p06"
     ARG             complement(3188..3738)
                     /name="aac(6')-Ib"
                     /gene="aac(6')-Ib"
                     /gene_name="AAC(6')-Ib family aminoglycoside
                     6'-N-acetyltransferase"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(3972..4529)
                     /locus_tag="HS642_RS00040"
                     /old_locus_tag="pKlebpneu15S_p07"
     CDS             complement(3972..4529)
                     /locus_tag="HS642_RS00040"
                     /old_locus_tag="pKlebpneu15S_p07"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221001.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001217881.1"
                     /translation="MRIFGYARVSTSQQSLDIQIRALKDAGVKANRIFTDKASGSSTDR
                     EGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVAVRFIDDGISTDGDMG
                     QMVVTILSAVAQAERRRILERTNEGRQEAKLKGIKFGRRRTVDRNVVLTLHQKGTGATE
                     IAHQLSIARSTVYKILEDERAS"
                     /name="recombinase family protein"
     gene            4691..7696
                     /locus_tag="HS642_RS00045"
                     /old_locus_tag="pKlebpneu15S_p08"
     CDS             4691..7696
                     /locus_tag="HS642_RS00045"
                     /old_locus_tag="pKlebpneu15S_p08"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032495017.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn3 family transposase"
                     /protein_id="WP_001143775.1"
                     /translation="MPVDFLTTEQVESYGRFTGEPDELQLARYFHLDEADKEFIGKSRG
                     DHNRLGIALQIGCVRFLGTFLTDMNHIPSGVRHFTARQLGIRDITVLAEYGQRENTRRE
                     HAALIRQHYQYREFAWPWTFRLTRLLYTRSWISNERPGLLFDLATGWLMQHRIILPGAT
                     TLTRLISEVREKATLRLWNKLALIPSAEQRSQLEMLLGPTDCSRLSLLESLKKGPVTIS
                     GPAFNEAIERWKTLNDFGLHAENLSTLPAVRLKNLARYAGMTSVFNIARMSPQKRMAVL
                     VAFVLAWETLALDDALDVLDAMLAVIIRDARKIGQKKRLRSLKDLDKSALALASACSYL
                     LKEETPDESIRAEVFSYIPRQKLAEIITLVREIARPSDDNFHDEMVEQYGRVRRFLPHL
                     LNTVKFSSAPAGVTTLNACDYLSREFSSRRQFFDDAPTEIISQSWKRLVINKEKHITRR
                     GYTLCFLSKLQDSLRRRDVYVTGSNRWGDPRARLLQGADWQANRIKVYRSLGHPTDPQE
                     AIKSLGHQLDSRYRQVAARLGENEAVELDVSGPKPRLTISPLASLDEPDSLKRLSKMIS
                     DLLPPVDLTELLLEINAHTGFADEFFHASEASARVDDLPVSISAVLMAEACNIGLEPLI
                     RSNVPALTRHRLNWTKANYLRAETITSANARLVDFQATLPLAQIWGGGEVASADGMRFV
                     TPVRTINAGPNRKYFGNNRGITWYNFVSDQYSGFHGIVIPGTLRDSIFVLEGLLEQETG
                     LNPTEIMTDTAGASDLVFGLFWLLGYQFSPRLADAGASVFWRMDHDADYGVLNDIARGQ
                     SDPRKIVLQWDEMIRTAGSLKLGKVQASVLVRSLLKSERPSGLTQAIIEVGRINKTLYL
                     LNYIDDEDYRRRILTQLNRGESRHAVARAICHGQKGEIRKRYTDGQEDQLGALGLVTNA
                     VVLWNTIYMQAALDHLRAQGETLNDEDIARLSPLCHGHINMLGHYSFTLAELVTKGHLR
                     PLKEASEAENVA"
                     /name="Tn3-like element Tn3 family transposase"
     gene            <7731..8021
                     /locus_tag="HS642_RS00050"
                     /old_locus_tag="pKlebpneu15S_p09"
                     /pseudo=""
     CDS             <7731..8021
                     /locus_tag="HS642_RS00050"
                     /old_locus_tag="pKlebpneu15S_p09"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /name="Exc2 family lipoprotein"
     gene            8327..8590
                     /locus_tag="HS642_RS00055"
                     /old_locus_tag="pKlebpneu15S_p10"
     CDS             8327..8590
                     /locus_tag="HS642_RS00055"
                     /old_locus_tag="pKlebpneu15S_p10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     gene            8580..8879
                     /locus_tag="HS642_RS00060"
                     /old_locus_tag="pKlebpneu15S_p11"
     CDS             8580..8879
                     /locus_tag="HS642_RS00060"
                     /old_locus_tag="pKlebpneu15S_p11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001146176.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(8941..9318)
                     /locus_tag="HS642_RS00065"
                     /old_locus_tag="pKlebpneu15S_p12"
     CDS             complement(8941..9318)
                     /locus_tag="HS642_RS00065"
                     /old_locus_tag="pKlebpneu15S_p12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            9387..9566
                     /locus_tag="HS642_RS00070"
                     /old_locus_tag="pKlebpneu15S_p13"
     CDS             9387..9566
                     /locus_tag="HS642_RS00070"
                     /old_locus_tag="pKlebpneu15S_p13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(9594..10124)
                     /locus_tag="HS642_RS00075"
                     /old_locus_tag="pKlebpneu15S_p14"
     CDS             complement(9594..10124)
                     /locus_tag="HS642_RS00075"
                     /old_locus_tag="pKlebpneu15S_p14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(10131..10862)
                     /locus_tag="HS642_RS00080"
                     /old_locus_tag="pKlebpneu15S_p15"
     CDS             complement(10131..10862)
                     /locus_tag="HS642_RS00080"
                     /old_locus_tag="pKlebpneu15S_p15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     gene            complement(10862..11341)
                     /locus_tag="HS642_RS00085"
                     /old_locus_tag="pKlebpneu15S_p16"
     CDS             complement(10862..11341)
                     /locus_tag="HS642_RS00085"
                     /old_locus_tag="pKlebpneu15S_p16"
                     /inference="COORDINATES: protein motif:HMM:NF024108.3"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_012561102.1"
                     /translation="MLAHQSLGDFGQCGQDLPAEFVKTTVLDNTPIRWFYRAASLESAQ
                     WAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQKEARPLFDVNTLQHLPDGFAVMTG
                     LGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEFRPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(11445..13160)
                     /gene="tnpR"
                     /locus_tag="HS642_RS00090"
                     /old_locus_tag="pKlebpneu15S_p17"
     CDS             complement(11445..13160)
                     /gene="tnpR"
                     /locus_tag="HS642_RS00090"
                     /old_locus_tag="pKlebpneu15S_p17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn4401 family resolvase TnpR"
                     /protein_id="WP_004152391.1"
                     /translation="MKTGQTTASSSTPVGFPDADSLAALRGWYAGLSSRAAVEHYLAAR
                     KAAGQSARGMLGHIRRQLIVFANSRHRPDLADVFQHAPEERQGRAGAVERAIRLLPTLP
                     APKPQISDSIDQWLSPRTVRALQAYGIHTLSALTVRIPRRRGWWKAIEGLGMTGARQVE
                     AFFAAHPQLTERARALIPIIQPSGIVPWEQLRLPNEVDGSQGNFRAPRNACTLNATNDY
                     EAVQAWLALHETVATQRAYRKEAARLILWAIVERGRALSSLTTDDAIAYRAFVRHPTPR
                     ERWVGPPRPRDSVEWRPFSGGLSARSAAYALTVLSALFRWLIEQRYVLANPFAGVKVRG
                     HALRPALDTARGFTEGEWLLLRAIADGLEWSYGWSEPAAQRLRFMLDFGYATGLRASEL
                     VGAVLGNVRLDEHGDHWLHLVGKGGKPGKVALPPLAYTALDQYLAQRQLPVSRERWNPK
                     TPLVGSLGEDGNAGITGPHLWCVLRRFFTQAAEAIEADHPVAAEKLRRATPHWMRHSHA
                     SHALARGAQLTAVRDNLRHASIATTSMYLHGDELERARQMRQAFGARHVKRGVD"
                     /name="tnpR"
     gene            13270..16299
                     /gene="tnpA"
                     /locus_tag="HS642_RS00095"
                     /old_locus_tag="pKlebpneu15S_p18"
     CDS             13270..16299
                     /gene="tnpA"
                     /locus_tag="HS642_RS00095"
                     /old_locus_tag="pKlebpneu15S_p18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152392.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn4401 family transposase"
                     /protein_id="WP_004152392.1"
                     /translation="MSKKNKLLSVLSDAEQEALYGLPEFDDAQQLEYLAVTETELALAN
                     SRPSLHAKVYCLLQIGYFKAKHAFFSFDWDEVEDDCAFVLSRYFHGEVFEPKAITKHER
                     YTQREQIAKLFGYWPWSAAFLPQLEQQAARTVRRDVTPGFVAAELIVWLNEHKIIRPGY
                     TTLQELVSETLSAERRRLGNLLEQALDESAKAALSQLLVRDDTLSQLAALKQDAKNFGW
                     RQMVREREKRATLEPLHAIAKTLLPKLDVSQQNLLYYASLANFYTVHDLRNLKADQTQL
                     YLLCYAWVRYRQLSDNLVDAMAYHMKQLEDESSAGAKQSFADEQVRRQQETPRVGRLLS
                     LYVDDSVADPTPFGEVRQRAYKIMPRDTLQTTAQRMSVKPASKLALQWQAVDGLADRMR
                     RHLRPLYVALDLSGSNPDSPWLAALAWAKGVFAKQQRLSQRPLDEWPAATLPKRLRPYL
                     LTFDADGKPTGLHADRYEFWLYRQIRKRLQSGELYLDDSLQHRHFSDELVEMDRKIDVL
                     AKMEIPFLQQPVHAQLDALTAELRTQWLAFNRELKQGKLTHLEYNKDTQKLTWRKPKSE
                     NEKAREKAFYEKLPFCDVADVFRFVNDECKFLSAFTPMQPRYAKKVADADSLMAVIIAQ
                     AMNHGNHVMARTSDIPYHVLDSGYQQYLRQATLHAANDCISNAIATLPIFPYYSFDLET
                     LYGAVDGQKFSVERPTVKARYSRKYFGRGKGVVAYTLLCNHIPLNGYLIGAHDYEAHHV
                     FDIWYRNTSDIMPTAITGDMHSVNKANFAILHWFGRRFEPRFTDLNAQLKELYCADDPA
                     QYQACLIRPVGKIDCDLIHREKPNIDRIVATLGLKEMTQGTLIRKLCTYTTTNPTRRAI
                     FEFDKLIRSIYTLRYLRDPQLERNVHRSQNRLESYHQLRSAIAQVGGKKELTGRTDIEI
                     EISNQCARLIANTIIFYNSAILSRLVTKYEAAGNSKALALITKISPAAWRHILLNGHYT
                     FQSSGKTIDLDAIVAGLELE"
                     /name="tnpA"
     gene            16406..17431
                     /gene="istA"
                     /locus_tag="HS642_RS00100"
                     /old_locus_tag="pKlebpneu15S_p19"
     CDS             16406..17431
                     /gene="istA"
                     /locus_tag="HS642_RS00100"
                     /old_locus_tag="pKlebpneu15S_p19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032490293.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS21 family transposase"
                     /protein_id="WP_004199214.1"
                     /translation="MLTQEQTVEIRVLARQGHSIRHIARTLGVSRNTVRRYLRDPSVAR
                     YQPREPRPTKLGPFESYLRQRVEQAHPIWLPATVLNREIRAQGYGGGLSLLRAFLATLK
                     PARREAGPAVRFETEPGRQLQADFVVLRRARSPMSAFVATLGYSRMTFVTFVPDESFES
                     VRDSLLLAFDYLGGVPREVLFDNMKTVVLERDAYGDGKHRFHPGLLQLADDLGFRIRLC
                     RPYRAQTKGKVERFNRYFRESFYNPLLTRMKGTGLLLDCAAANRRVRDWLADEANVRVH
                     ATLNERPIDRWRQEREHLQPLPSRVRRDEAPLLDNSLRPVPLESLQHPLSVYDAIGEAC
                     R"
                     /name="istA"
     gene            17428..18207
                     /gene="istB"
                     /locus_tag="HS642_RS00105"
                     /old_locus_tag="pKlebpneu15S_p20"
     CDS             17428..18207
                     /gene="istB"
                     /locus_tag="HS642_RS00105"
                     /old_locus_tag="pKlebpneu15S_p20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS21-like element ISKpn7 family helper ATPase
                     IstB"
                     /protein_id="WP_004152394.1"
                     /translation="MNLQHERIDALCQQLKLERVATHYPVLAQQAVREDFSFTDFLEHL
                     LRHEAGCRQQRSRELLTRMACFPGIKTLEDYDFSFNPGVPKALVQELGSLAFVERAENV
                     VLIGPSGIGKTHLAIALGYKAAQAGVKTRFITAADLMLQLSTAQRQGRLKEYFNRAILG
                     PRLLVIDEIGYLPFGREEANLFFQVVAKRYEKGAMILTSNLPFSQWADAFAGDTTLTAA
                     MLDRLLHHAHILTLSGESYRLKDKRKAGVVRKNSKPE"
                     /name="istB"
     gene            18204..18443
                     /locus_tag="HS642_RS00125"
     CDS             18204..18443
                     /locus_tag="HS642_RS00125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004152395.1"
                     /translation="MIQVGQYYFGDSGVKWVSFQLVLTPAYPRCYLRAPIVGAWPGLPE
                     AVRNVDAEVRRGGRPMNADLIRFSSSVIIPAVAA"
                     /name="hypothetical protein"
     gene            18495..19376
                     /locus_tag="HS642_RS00110"
                     /old_locus_tag="pKlebpneu15S_p21"
     CDS             18495..19376
                     /locus_tag="HS642_RS00110"
                     /old_locus_tag="pKlebpneu15S_p21"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015256839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbapenem-hydrolyzing class A beta-lactamase
                     KPC-2"
                     /protein_id="WP_004199234.1"
                     /translation="MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIG
                     VYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPW
                     SPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDR
                     WELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRA
                     AVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAA
                     RLALEGLGVNGQ"
                     /name="carbapenem-hydrolyzing class A beta-lactamase KPC-2"
     gene            complement(19626..20945)
                     /locus_tag="HS642_RS00115"
                     /old_locus_tag="pKlebpneu15S_p22"
     CDS             complement(19626..20945)
                     /locus_tag="HS642_RS00115"
                     /old_locus_tag="pKlebpneu15S_p22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152397.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1182-like element ISKpn6 family transposase"
                     /protein_id="WP_004152397.1"
                     /translation="MAASYLPYRPDQSYLLPPSLGEWLPEGHLAYFISETVDTLDLSAF
                     HARYAGGGPGNQPFHPAMMVKVLIYGYASGVFSSRKLARKLYEDVALRVLAAGNFPAHR
                     TLSDFRALHLTELENLFVQVVQLARECGLVKLGTIAVDGTKVKANASRHKAMSYKRMKP
                     AEDELHCEIKALLDRAKATDDQERNEPELDIPAEISRREKRLEAIQAAKARLEARQREA
                     DQARGRSEDDGRRPRHPDGSDKGGGSYKREFGVPDDRDQESFTDPDSRIMKHAGGGSEQ
                     SYNGYTAVDAEHQIIVAAELTNCAADSQALLGMLAAVQANTGEMPAQTLADAGFRSEAV
                     LAKVADHHGDVIVALGREGREDAKVNAKTHPHTAAIAAKLKTEQGDAAYRRRKSIVEAP
                     NGWIKAVMGLRQFSMRGLDKVQAEWKLVCMALNLRRMAYL"
                     /name="IS1182-like element ISKpn6 family transposase"
     gene            complement(21299..22738)
                     /locus_tag="HS642_RS00120"
                     /old_locus_tag="pKlebpneu15S_p23"
     CDS             complement(21299..22738)
                     /locus_tag="HS642_RS00120"
                     /old_locus_tag="pKlebpneu15S_p23"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_012561103.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSK"
                     /name="hypothetical protein"
     ARG             18496..19373
                     /name="blaKPC-2"
                     /gene="blaKPC-2"
                     /gene_name="carbapenem-hydrolyzing class A beta-lactamase
                     KPC-2"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(2846..3102)
                     /name="aadA15"
                     /gene="aadA15"
                     /gene_name="ANT(3'')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="97.14"
                     /coverage="32.32"
     ARG             complement(3185..3789)
                     /name="AAC(6')-Ib10"
                     /gene="AAC(6')-Ib10"
                     /gene_name="AAC(6')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="98.97"
                     /coverage="99.01"
     Typing          complement(2..200)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="89.109"
                     /coverage="99.0"
                     /evalue="1.87e-63"
     Typing          23538..23753
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="90.367"
                     /coverage="100.0"
                     /evalue="4.56e-74"
     Typing          complement(10135..10862)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.3599999999999998e-150"
ORIGIN
        1 ttcccggata cctgttccgc ctttctccct tgcgggaagt gtggcgcttt ctcatagctc
       61 acactctggt atctcggctc ggtgtaggtc gttcgctcca agctgggctg taagcaagaa
      121 ccccccgttc agcccgactg ctgcgcctta tccggtaact gttcacttga gtccaacccg
      181 gaaaagcacg caaaacgcca ctggcagcag ccattggtaa ctgggagttc gcagaggatt
      241 tgtttagcta aacacgcggt tgctcttgaa gtgtgcgcca aagtccggct acactggaag
      301 gacagatttg gttgctgtgc tctgcgaaag ccagttacca cggttaagca gttccccaac
      361 tgacttaacc ttcgatcaaa ccacctcccc aggtggtttt ttcgtttaca gggcaaaaga
      421 ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctact gaaccgcgat
      481 ccccgtcagt tcagaggagg acgatggtgc caccgttcca ccctgaacat cccggatata
      541 gtttgcctga catgcgacca gaagaaagcc tgaaaaaatc aatataaaaa gaaaaacaac
      601 ctttaccttt ttcatatacc ttccctgtat ttaaaaaccc cggtattcat ccctgaacac
      661 cggaagtctg tatttcaaat catccttgat aacttttgct taccagttac catcccggta
      721 aacaaaggat acaaagtaat caaatttact aatatcgatt acatttttaa agtgtggctg
      781 taatatcgaa acccatgatt tttcaacatc aaaccaacca ttattaatat tatcctttaa
      841 aggcatcccc agactttcaa tgacagaacc atcatcaccg aagtcttttg agtattcacc
      901 acctttaaac tcttcggttt tcttatcaaa ccaatgaata tgtaatttaa gccccatatt
      961 tacctcttaa agatattttt taatgtttcg ttttggatcc ggccctttaa cctgcttacc
     1021 cgtttttgga tcgaatgccc cgaggtgttc gccatcactg gcgcggtacc cttcaagctc
     1081 accgtgctgg gaatcccatt cataaatttt acgcttttta tcaccatacc atcgggcccg
     1141 cttaccacca ccaccttgtt taggggtttt aggtttaccc tctttcaact ctcccaaccc
     1201 cttaatatct tcagtcttgg gatcaggaaa ataatcatgg ccgtaatctt tagttccctt
     1261 acgaggtttt ttcttttcct catttaattt attttctgca tccttcgctt ttttctcctt
     1321 ttgtttccgg ctctccatcg ccccggaaag cgcagcctta tccctggata aggattcatt
     1381 catttcgttt aaagatgtct gggcagcttt taatttctca ttctgattct gaatatcctt
     1441 atcaagatag cgaacctgat cctgccaccc ggagccatat tcatgaggcg ggttataagt
     1501 cacaaaatca tctttatttg cctctgcctc ttttaccttt ttatcggctt cctgaacagc
     1561 agcccttgca ccggggatcg ccttctctgt cgatgcaatg cgactgttta aggtcgcaat
     1621 atttttatct tcagcatcca gctcagcttt cgctttatca tactctcttt tcagcccctc
     1681 ttccgggtga gcagcgtccc atgcctgctg gcgacgcttt tcttcctcca gacgctgttt
     1741 tacctgtgcc ggagtagggg tctgacgctc agtggaacga aaactcacgt taagggattt
     1801 tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt
     1861 ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca
     1921 gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg
     1981 tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac
     2041 cgcgagaccc acgctcaccg gctccagatt tatcagggca ctgttgcaaa gttagcgatg
     2101 aggcagcctt ttgtcttatt caaaggcctt acatttcaaa aactctgctt accaggcgca
     2161 tttcgcccag gggatcacca taataaaatg ctgaggcctg gcctttgcgt agtgcacgca
     2221 tcacctcaat acctttgatg gtggcgtaag ccgtcttcat ggatttaaat cccagcgtgg
     2281 cgccgattat ccgtttcagt ttgccatgat cgcattcaat cacgttgttc cggtacttaa
     2341 tctgtcggtg ttcaacgtca gacgggcacc ggccttcgcg tttgagcaga gcaagcgcgc
     2401 gaccataggc gggcgcttta tccgtgttga tgaatcgcgg gatctgccac ttcttcacgt
     2461 tgttgaggat tttacccaga aaccggtatg cagctttgct gttacgacgg gaggagagat
     2521 aaaaatcgac agtgcggccc cggctgtcga cggcccggta cagatacgcc cagcggccat
     2581 tgaccttcac gtaggtttca tccatgtgcc acgggcaaag atcggaaggg ttacgccagt
     2641 accagcgcag ccgtttttcc atttcaggcg cataacgctg aacccagcgg taaatcgtgg
     2701 agtgatcgac attcactccg cgttcagcca gcatctcctg cagctcacgg taactgatgc
     2761 cgtatttgca gtaccagcgt acggcccaca gaatgatgtc acgctgaaaa tgccggcctt
     2821 tgaatgggtt catgtgcagc tccatcagca aaaggggatg ataagtttat caccaccgac
     2881 tatttgcaac agtgccgttt ccaaaaggtc gttgatcaaa gctcgccgcg ttgtttcatc
     2941 aagccttacg gtcaccgtaa ccagcaaatc aatatcactg tgtggcttca ggccgccatc
     3001 cactgcggag ccgtacaaat gtacggccag caacgtcggt tcgagatggc gctcgatgac
     3061 gccaactacc tctgatagtt gagtcgatac ttcggcgatc accgcttccc tcatgatgtt
     3121 taacgtttga catgaggggc ggccaagggc gccagccctt ggacgtcccc ctcgatggaa
     3181 gggttaggca acactgcgtg ttcgctcgaa tgcctggcgt gtttgaacca tgtacacggc
     3241 tggaccatct ggggtggtta cggtaccttg cctctcaaac cccgctttct cgtagcatcg
     3301 gatcgctcgc aagttgctcg gcgacgggtc cgtttggatc ttggtgacct cgggatcatt
     3361 gaacagcaac tcaaccagag ctcgaaccag cttggttccc aagcctttgc ccagttgtga
     3421 tgcattcgcc agtaactggt ctattccgcg tactcctgga tcggtttctt cttcccacca
     3481 tccgtccccg cttccaagag caacgtacga ctgggcatac ccaatcggct ctccattcag
     3541 cattgcaatg tatggagtga cggactcttg cgctaaaacg cttggcaagt actgttcctg
     3601 tacgtcagca agtgtcgggc gtgcttcttc tccgccccac cactcgacga tatgagatcg
     3661 atttagccac tcatagagca tcgcaaggtc atgctcagtc atgaggcgca gtgtgacgga
     3721 atcgttgctg ttggtcacga tgctgtactt tgtgatgcct aactttgttt ggaaatgttg
     3781 aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat
     3841 gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacttt
     3901 tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa
     3961 aaataggcgt atcacgaggc cctttcgtct tcaagaattt tataaaccgt ggagcgggca
     4021 atactgagct gatgagcaat ttccgttgca ccagtgccct tctgatgaag cgtcagcacg
     4081 acgttcctgt ccacggtacg cctgcggcca aatttgattc ctttcagctt tgcttcctgt
     4141 cggccctcat tcgtgcgctc taggatcctc cggcgttcag cctgtgccac agccgacagg
     4201 atggtgacca ccatttgccc catatcaccg tcggtactga tcccgtcgtc aataaaccga
     4261 accgctacac cctgagcatc aaactctttt atcagttgga tcatgtcggc ggtgtcgcgg
     4321 ccaagacggt cgagcttctt caccagaatg acatcacctt cctccacctt catcctcagc
     4381 aaatccagcc cttcccgatc tgttgaactg ccggatgcct tgtcggtaaa gatgcggtta
     4441 gcttttaccc ctgcatcttt gagcgctctg atctgaatat cgagggactg ctggctggtt
     4501 gagacccgcg cataaccaaa aattcgcata aaaatgtacc ttaaatcgaa tatcagacac
     4561 gatgtgtcta ttatgccaaa atgacgattt aatggacact caaacgaagc cgttttacta
     4621 tgtctgataa tttataatat ttcgaacggt tgcagttgtg ttaaaaaagc cgtcaggcag
     4681 ggaggccgat atgcccgttg attttttgac cactgagcag gttgagagtt atggcaggtt
     4741 cactggcgaa cccgatgaac ttcagctggc gcgttatttt catcttgatg aagcggataa
     4801 agaatttatc gggaaaagcc ggggtgatca caatcgactt ggtattgccc tgcaaatcgg
     4861 gtgtgtgcgt tttctgggca cttttcttac tgacatgaat catattcctt ccggcgtccg
     4921 gcattttacc gccagacagc tcgggattcg tgatatcacc gttcttgcag aatacggtca
     4981 gagggaaaat acccgccgtg agcatgcagc gctgatacgt cagcactatc agtatcgtga
     5041 atttgcctgg ccctggacat ttcgccttac ccgtctttta tatacccgga gctggataag
     5101 caacgaacgt cctggcctgc ttttcgacct ggcgacaggg tggcttatgc aacatcgtat
     5161 tattctcccc ggagccacca cgctgacccg gttgatttca gaggtaaggg aaaaggcgac
     5221 gttgcgcctg tggaacaaac tggcactgat accgtcagcc gaacagcgtt cacagctgga
     5281 gatgctgctg gggccaactg attgcagccg cctgtcttta ctggaatcac tgaaaaaagg
     5341 ccctgtgacc atcagtggtc cggcgtttaa tgaagcaatt gaacgctgga aaactctgaa
     5401 cgattttggc ctgcatgctg aaaacctgag tacactcccg gctgtgcgcc tgaaaaatct
     5461 cgcacgttat gctggtatga cttcggtgtt caatattgcc aggatgtcac cgcagaaaag
     5521 gatggcggtt ctggttgcct ttgtccttgc atgggaaacg ctggcgctgg atgatgcact
     5581 ggacgttctg gacgccatgc tggccgttat catccgtgac gccagaaaga ttgggcagaa
     5641 aaaacggctc cgctcgctga aggatctgga taaatctgca ttggcgctcg ccagcgcatg
     5701 ttcgtacttg ctgaaagaag aaacaccgga cgaatcgatt cgtgctgagg tgttcagcta
     5761 catccctagg caaaagctgg ctgaaatcat cacgcttgtc cgtgaaattg cccggccctc
     5821 agacgataat tttcatgacg aaatggtgga gcagtacggg cgcgttcgtc gtttcctgcc
     5881 ccatctgctg aataccgtta aattttcatc cgcacctgcc ggggttacca ctctgaatgc
     5941 ctgtgactac ctcagccggg agttcagctc acggcggcag ttttttgacg acgcaccaac
     6001 ggaaatcatc agtcagtcat ggaaacggct ggtgattaac aaggaaaaac atatcacccg
     6061 aaggggatac acgctctgct ttctcagtaa actgcaggat agtctgagac ggagggatgt
     6121 ctacgttacc ggcagtaacc ggtggggaga tcctcgtgca agattactac agggtgctga
     6181 ctggcaggca aatcggatta aggtttatcg ttctttgggg cacccgacag acccgcagga
     6241 agcaataaaa tctctgggcc atcagcttga tagtcgttac agacaggttg ctgcacgtct
     6301 tggcgaaaat gaggctgtcg aactcgatgt ttctggcccg aagccccggt tgacaatttc
     6361 tcccctcgcc agtcttgatg agccggacag tctgaaacga ctgagcaaaa tgatcagtga
     6421 tctgctccct ccggtggatt taacggagtt gctgctcgaa attaacgccc ataccggatt
     6481 tgctgatgag tttttccatg ccagtgaagc cagtgccaga gttgatgatc tgcccgtcag
     6541 catcagcgcc gtgctgatgg ctgaagcctg caatatcggt ctggaaccac tgatcagatc
     6601 aaatgttcct gcactgaccc gacaccggct gaactggaca aaagcgaact atctgcgggc
     6661 tgaaactatc accagcgcta atgccagact ggttgatttt caggcaacgc tgccactggc
     6721 acagatatgg ggtggaggag aagtggcatc tgcagatgga atgcgctttg ttacgccagt
     6781 cagaacaatc aatgccggac cgaaccgcaa atactttggt aataacagag ggatcacctg
     6841 gtacaacttt gtgtccgatc agtattccgg ctttcatggc atcgttatac cggggacgct
     6901 gagggactct atctttgtgc tggaaggcct tctggaacag gagaccgggc tgaatccaac
     6961 cgaaattatg accgatacgg caggtgccag cgatcttgtc tttggccttt tctggctgct
     7021 gggataccag ttttctccac gcctggctga tgccggtgct tcggttttct ggcgaatgga
     7081 ccatgatgcc gactatggcg tgctgaatga tattgccaga gggcaatcag atccccgaaa
     7141 aatagtcctt cagtgggacg aaatgatccg gaccgcaggc tccctgaagc tgggcaaagt
     7201 acaggcctca gtgctggtcc gttcattgct gaaaagtgaa cgtccctccg gactgactca
     7261 ggcaatcatt gaagtggggc gcatcaacaa aacgctgtat ctgcttaatt atattgatga
     7321 tgaagattac cgccggcgca ttctgaccca gcttaatcgg ggagaaagcc gtcatgcagt
     7381 tgccagagcc atctgtcacg gtcaaaaagg tgagataaga aaacgatata ccgacggtca
     7441 ggaagatcag ttgggagctc tggggctggt cactaacgcc gtcgtgttat ggaacactat
     7501 ttatatgcag gcagctctgg atcatctccg ggcgcagggt gaaacactga atgatgaaga
     7561 tatcgcacgc ctctccccgc tttgccacgg acatatcaat atgctcggcc attattcctt
     7621 cacgctggca gaactggtga ccaaaggtca tctgagacca ttaaaagagg cgtcagaggc
     7681 agaaaacgtt gcttaacgtg agttttcgtt ccactgagcg tcagacccct tttgatccca
     7741 atttttccac ccagaaagct gacacaacac gaatgatggt gccttttttc cggcagttct
     7801 gggatatggg cgcaaaggat aaagcgaccg gaaaatcacg gagtgatgtg cagcaacgca
     7861 ttcagcagtt tcacagtcag gaatttttaa actcactcca aggcacaaca caatttgcgg
     7921 gtaccgatta ccgcagcaaa gacctcacac cgaaaaaatc aaggctactg gctgacacca
     7981 tttcagctgt ttatctcgat ggctatgaag gcagacagta agtggattta ccataacgcg
     8041 tcattacgcg caccgctcag acgggctcag ggcgtttccg gcggctacgg gataaaacag
     8101 gcaacaaccc ccccggaaaa ctgccggaaa cgcgcccgat aaattttatc ctaatgcatg
     8161 cctatgcacg caactgcatg gcatatgttt tgacgtaaaa tggatgccgt aagccctttt
     8221 ttaccgactt tctgcttcat cagcctgact gacacgacca tattctttca gaccgccccc
     8281 tgctaaactt ccttcatatt gccgcattaa cccgggaggc tccgcaatga gcaacactac
     8341 acactacgaa aacgccaact ttcttcggga actggctgaa agcctgcccc gcatactgcc
     8401 ggaaggtggc ccggacaaag ctgcgctgtt gcagcgactg gctaacgaag aactggccca
     8461 ggcagagtat gaagatcagg ttcgcgccaa agtgaccgcc gcccgtgctg acacgcgtcc
     8521 gggtatgacc acggaacaac tccgccagcg cctgcatggc cgttatcagg aactgcgcga
     8581 tgccgtatga cgtggaatgg aagcagggag ccatcgagga tgtaacgacg ctgtttgact
     8641 atatcgcgga aaattcatcc ctgtgggatg cgcagaacgt taccgaccgg gttctcgctg
     8701 cggcggacaa actggccgac ttcccgcgac tctatgaagt ggactcacgc tatggcgagg
     8761 acgttcgccg gatcagtctg atgggacagc atgtcctcta tgatgttgat gaccagacca
     8821 gaaaagtccg ggttctggcc gtggtcggcc agcgccagaa tccccatatt gttctctaat
     8881 aaccggtgac ggggacgcaa ttcattgcgt ggccgtcgcc ggttggacaa gcacagcgcg
     8941 tcagcgtttt ccccacggcc accaccggcg cggtgttccg gccggggtct ctgctgtctc
     9001 cggtttgtgt tccagcagtc tcatggactg catttcctgc cgtagcccgg ccacctcctc
     9061 cctgagtgct tttatctccg cgatcaacgc gtcggaggcc attttttcag tctcacccga
     9121 cagtctcaac tcgtcccgct cgtgagtctc atcctgtctt aactcaccgt acacccggat
     9181 aagctcgctg gtatccacca cccggccgcc atcagcttcc gtacggtatg atacgcggcc
     9241 tttcgccata tcccgataca gggaacttcg ggctttaccc gtcagttccg tcgcctgtct
     9301 caccgtcacc cacgccattg tctcaccccg ctatttttga gacagtatac ctgacaggcg
     9361 cacaccatgc ccggaaggaa agaatcatga caaaacagga aaaaacagcc ctcaatatgg
     9421 ctaaatttat taaggagcag tcgctgctat tgctcgataa actgaatgag ctggatatgg
     9481 ataccccggc cgacatgtgc gagcggctac acgaggatgc ggaaacactc tggcaggtga
     9541 tgcgggataa gctcggggag gaataacagc accggcatgg ccggtgctgg catttatttt
     9601 ttgccgaacg gccaccaccg gcgggcaggt ttgtcctccg gcagttcagg taccggcacg
     9661 ttaaaatagc ggctgttata ttcccgcatc agctccgctt tcagcttctc gttcaccgcg
     9721 ctttccccgt gccgctcact caccacgtca atcatcgcgt taatctgctc cggtgagcac
     9781 ttcccggcat caaccacctg cacaccgttc tcgatggcga accgctccac cttgcgatag
     9841 aggtaatcac acagcttcat tcctgtgggt ttgttccgtt cccattgcgg atttttacca
     9901 gtgaaaaagt acgtggcttt ttcgtcgctg ttgagccgct cgtcatacat cccgatggat
     9961 ttcatcatcg ccagatgctg ggcccggtcg acaaaacaga aaacatacgc cccggtctgc
    10021 caggcgagca ccaccatatc ttccagatgc tcgctggtcg gcatgatgca gcgctcgccg
    10081 ttccggtcct ccgcgtcttc aataaatacc atgtacagcg ccataatccc tcactccgtt
    10141 gtcataaatt taaagcacgc aaacaaccgt tcacgatcca gctctgccgt tttgcgggcc
    10201 tcgccggtct gtgggttcac gatttcatcc accgacagga ttgcccgctg caccctgacc
    10261 tgcgtcgccc ggtccgggca gatgtaccag atttcatcga tgccgttagc tttgcggttg
    10321 aacagatacc cggacaccac ttcctgatac cggcgacggc tcttgacggt gcgctccacc
    10381 tcaaacgcca ccgttttacc gtccagctcc gccagggcgt ccggcacttt catgccttta
    10441 agactcagac ggtgcagaat gcgccagccg gtggcccctc tggcttccat atcaaggcgc
    10501 agggattgca cggccagccg gtgcggcaga tgtgctgccg acacccttga cggctgaaac
    10561 ggaataacat ccgccagcgg ttcgtcctcg tcgaacgaga acgccacgcc atgcggcgtc
    10621 agcccccaca cgctgacctg acggccgtcc accggatatt tggtccggac cagcagccct
    10681 ttcgccacca ggctgtcgag gaagcggtag accggctgca ccgccgcaat ccccagccgc
    10741 cgcgcaacca gctccgccgt ggaacacagc tcttcccgca accagcgcag ggtcagccgg
    10801 gttttctccg cgttccgcgc ctgtcgtttc gcgtggctga cgttgtacag ctccagcgcc
    10861 atcagtaaat ccccgcaaaa tcatcatccg ctttcggccc gccgccgtcg gccgggggcc
    10921 ggaactccgc caggggatcg gttttcgcca gcaccgggaa acgctgcaac gggatttccc
    10981 ggcgctcaac ccgcagcgga ctgctgaacg ccatccgggc cacacccagc ccggtcatga
    11041 ccgcgaaccc gtccggcagg tgttgcaggg tgttcacgtc aaacagcggc cgcgcctcct
    11101 tctggatgaa gctgtccccg ctgatatgct ccacgttccc cgcctcccgg ctggcacggc
    11161 ggcgctccac gtccaccctg atttccccgg tctgccccgc cgcccactgc gcggactcca
    11221 ggctggccgc ccggtaaaac cagcggatcg gcgtgttatc cagtaccgtg gttttcacaa
    11281 attcagcggg cagatcctgc ccgcactgcc cgaaatcgcc cagcgactgg tgcgcgagca
    11341 acagattgca gtcccggctg cgcagcgtcc ccagtgcgtt cagtacatac ttggggttct
    11401 aagcgggaat cccagaaaat tccgtcattc cgtatgatga aaattcagtc gactcctcgc
    11461 ttgacgtgac gagcgccaaa agcctgccgc atctgcctgg cgcgctcgag ctcatcgcca
    11521 tgcaaataca tcgacgtcgt ggcgatcgac gcatggcgta ggttgtcgcg caccgcggtg
    11581 agctgagctc cccgggccaa cgcatggctg gcatgactgt gacgcatcca atgaggcgtg
    11641 gcacggcgca gcttttcggc ggcgaccgga tgatcggcct caatggcctc agcggcttgc
    11701 gtaaagaatc ttcgcaacac gcaccaaagg tgagggccgg tgatgccggc attaccgtct
    11761 tccccaagac tgcccaccag gggcgttttc ggattccacc gttcccggct gactggcagt
    11821 tgacgctgtg ccaagtattg gtccagcgcc gtatacgcga gcggcggcaa ggccacctta
    11881 cctggtttgc cacctttgcc aaccaaatgc agccagtggt caccgtgctc gtcgaggcgg
    11941 acattaccca ggacggcgcc gaccagttcg ctagcgcgca ggcccgtggc atagccgaag
    12001 tcgagcatga agcgcaggcg ttgtgctgcc ggctcggacc agccgtagga ccattccagg
    12061 ccgtctgcaa tggcgcgcag cagtagccat tctccctcgg taaagcctcg cgccgtatcc
    12121 agtgcgggcc gcaaggcgtg accgcgtacc ttgacgccgg cgaaagggtt ggccagcaca
    12181 tagcgctgct cgatgagcca ccggaacagc gccgagagca ccgtcagcgc atacgctgcc
    12241 gagcgtgcgg acaagccgcc cgagaagggg cgccattcca ccgaatcgcg tggtcgaggt
    12301 ggccccaccc aacgctcgcg cggggtcggg tgccggacaa aggcccggta cgcgattgca
    12361 tcgtccgtgg tcagggatga tagcgcccgt ccgcgttcga cgatggccca caggattagc
    12421 cgcgcagcct ccttgcgata ggcgcgctgt gtggcgacag tctcgtgcag cgccagccag
    12481 gcctgcacgg cctcgtagtc gttggtcgca ttcagcgtgc aagcgttgcg cggggcccgg
    12541 aaattgccct gcgagccgtc gacttcgttc ggcagacgca actgctccca cggcacgatg
    12601 ccgctgggct gaataatcgg gatcagggcc cgggcgcgct cggtgagctg cggatgtgcg
    12661 gcaaagaaag cctcgacctg ccgggcgcct gtcatgccga gtccctcgat ggctttccac
    12721 cagccacgcc ggcggggaat gcgcacggtc agcgccgaga gggtgtggat accgtacgcc
    12781 tgcagtgccc tgacggtcct cggagacagc cactggtcga tgctgtcgct gatctggggc
    12841 ttcggcgccg gcagcgtggg caagagccgg atcgcgcgtt cgacggcacc cgcgcgcccc
    12901 tgtcgctctt cgggggcgtg ctggaacacg tcggccagat ccggccggtg gcggctgttg
    12961 gcgaaaacga tgagctggcg gcggatatgc cccagcatcc ctcgcgctga ttgaccggcg
    13021 gccttgcgtg ccgccaggta gtgttcaacg gccgcgcgag agctgagtcc cgcgtaccag
    13081 ccgcgcaagg cagccagcga atccgcatcg ggaaagccga ctggggtaga actcgaagcc
    13141 gtagtctggc ccgttttcat atggacaggt tgcgattcga aaagcgagta acgcgataat
    13201 aacgattatt tcagtagaat cgaaaatgcc ccatgtttct acgaaacctc aagatagcaa
    13261 gaacgggcca tgagcaagaa gaacaagcta ctcagcgtcc tatccgacgc cgaacaggag
    13321 gccttgtatg gcctgccgga gttcgatgat gcgcagcagc tggaatatct ggctgtgaca
    13381 gaaaccgagt tggcgcttgc caacagccgg cccagtcttc atgccaaggt ctattgcctc
    13441 ttgcagatcg gctacttcaa ggccaagcat gccttcttca gtttcgactg ggacgaagtc
    13501 gaggacgatt gcgctttcgt gctgagccgc tatttccacg gcgaggtgtt cgaacccaag
    13561 gcgatcacca agcatgaacg ctacacccag cgcgagcaga tcgccaaact attcggctac
    13621 tggccgtggt cggccgcctt cctgccgcag ctcgagcagc aggccgcacg gaccgtgcgg
    13681 cgtgacgtaa cgccggggtt cgtcgccgcc gagctgatcg tctggctcaa tgagcacaag
    13741 attatccggc ccggctatac gaccttgcaa gagttggtca gcgaaacgct atccgccgag
    13801 cgccggcgcc tgggcaatct gctggagcaa gcgttggacg aatctgccaa ggccgcgctg
    13861 agccagcttc tggtccgtga tgacaccctg tcgcaactgg cggcgctcaa gcaggacgcc
    13921 aagaatttcg gctggcgcca gatggtccgc gagcgcgaaa agcgcgccac gctggagccg
    13981 ctgcacgcaa tcgccaagac actgctgcct aaactcgacg tctcgcagca gaacctgctg
    14041 tactacgcga gcctggcaaa cttctacacc gtccacgacc tgcgcaatct gaaggccgat
    14101 cagacccaac tctacctgct gtgctatgcc tgggtacgct accggcagct ctccgacaac
    14161 ctggtcgatg cgatggcgta ccacatgaag cagttggagg acgaaagcag cgctggtgcc
    14221 aaacaatcct ttgccgacga gcaggtgcgc cgtcagcagg aaacgccgcg ggtaggccgc
    14281 ctgctgtcac tctacgttga tgatagcgtg gccgatccca cgcccttcgg cgaggtgcgg
    14341 cagcgcgcct acaagatcat gcctcgcgat acgctgcaaa ccacggcgca gcgtatgagc
    14401 gtgaagccgg cgagcaagct ggccttgcag tggcaggcgg tggacgggct ggccgaccgc
    14461 atgcgccgcc atcttcgtcc actgtacgtt gcgctcgacc tctccggctc caatccagac
    14521 agtccatggc ttgccgcgct ggcctgggcc aaaggtgttt ttgccaagca gcagcggctg
    14581 tcgcaacggc cactcgacga gtggcccgcg gcgacacttc cgaaacgctt gcggccgtac
    14641 ctgctgacct tcgacgccga cggtaaacca accggcctgc acgctgaccg ctacgagttc
    14701 tggctgtacc gccagatcag gaagcgtctc caatcgggtg aactctacct cgacgacagc
    14761 ctgcaacacc ggcacttctc agatgaactg gttgagatgg acaggaagat cgatgtgctc
    14821 gcaaaaatgg agatcccctt cctgcagcaa cccgtccatg cccaactcga tgcgctgact
    14881 gccgaactgc gcacgcagtg gctggcgttc aaccgcgagc tgaaacaggg caagctgacg
    14941 cacctcgaat acaacaagga cacgcagaaa ctgacctggc gcaagcccaa gagcgagaat
    15001 gagaaagcgc gcgaaaaggc attctacgag aagcttccgt tctgcgacgt ggccgacgtg
    15061 tttcgcttcg tcaacgacga gtgcaagttt ctgtcggcgt tcacgcccat gcagccgcgc
    15121 tacgcgaaga aggtcgccga cgctgacagc ctgatggcgg tcatcatcgc gcaagcgatg
    15181 aaccacggca accacgtcat ggcgcgcacc agcgacatcc cgtaccacgt gctggatagc
    15241 ggctaccagc agtacctgcg ccaggcaacg ctgcacgcgg ccaacgactg catcagcaac
    15301 gccatcgcca cgctaccgat cttcccatac tactcgttcg acctcgaaac gctgtacggt
    15361 gccgtcgacg ggcagaaatt cagcgtcgaa cggccgaccg tgaaggcgcg ctattcgcgc
    15421 aagtacttcg ggcgcggcaa gggcgtggtc gcctacacgc tgctgtgcaa ccacatcccg
    15481 ctcaacggct acctgatcgg cgcgcacgac tacgaggccc accacgtgtt cgacatctgg
    15541 tatcgcaaca cgtcggacat catgccgacc gcgatcaccg gcgacatgca cagcgtcaac
    15601 aaggccaact tcgccatcct gcattggttt ggccggcggt tcgagccgcg cttcaccgac
    15661 ctcaacgcgc aattgaaaga actctactgc gctgacgatc cagcacagta tcaggcgtgc
    15721 ctgattcggc cagtcgggaa aatcgactgc gatctcatcc atcgcgagaa gccgaacatc
    15781 gaccggatcg tcgccacact cgggctgaag gaaatgacgc agggcacgct gatccgcaag
    15841 ctgtgcacct acaccacgac gaacccgacg cggcgcgcga tcttcgagtt cgacaagctc
    15901 atccgcagca tctacacgct tcgctacctg cgcgatccgc aactggaacg caacgtgcac
    15961 cgctcgcaaa atcgcctcga gtcctaccat cagctacgct cggccattgc ccaggtcggc
    16021 ggtaagaagg aactgaccgg tcgcaccgac attgaaatcg agatcagcaa ccagtgcgca
    16081 cggctgatcg ccaacacgat cattttctac aactcggcaa tcttgtcgcg gctggtgacc
    16141 aagtacgagg cggccggcaa cagcaaggcg ctggcactca tcacaaaaat ttcgcctgcg
    16201 gcatggcggc acatcctgct caacgggcac tacacctttc aaagcagcgg caagacgatc
    16261 gatctcgatg cgatcgtcgc aggcctggaa ctggagtgac ggaattttca gcggttccgt
    16321 gttagcagca gtgtaaaact gacccacccc agcgaagtaa aactgatcca cctgggctag
    16381 tttggcggcc ttttcgaggc cgtcgatgtt gacccaggag caaaccgtgg aaatcagagt
    16441 tcttgcccga cagggccact ccatccggca catcgcccgc acgttggggg tctcgcgcaa
    16501 taccgtgcgc cgctacctcc gcgatccgtc ggtagcgcga taccagcccc gtgaaccacg
    16561 ccccaccaaa ctggggccat ttgaatctta tctgcggcaa cgggtcgagc aggcccaccc
    16621 catctggctg cctgccaccg tcctgaatcg ggaaatccgc gctcaagggt atggcggcgg
    16681 tctctcgtta ttgcgcgcct tcctcgccac gctcaagccc gcccgccgcg aagcaggtcc
    16741 ggccgtccgt ttcgagaccg agcccggacg gcagttgcag gctgatttcg tggtcttgcg
    16801 ccgggccaga tcccccatgt cggccttcgt cgccacgctg ggatacagcc gcatgacgtt
    16861 tgtcaccttc gtaccggacg aatccttcga gtccgtgcgg gactccctgt tgctggcttt
    16921 tgactatctg ggcggtgtgc cccgcgaggt gttgttcgac aacatgaaga ccgtggtgct
    16981 ggaacgcgat gcctacggtg acggcaagca ccgttttcac cccggcttgc ttcaactggc
    17041 cgatgacctg gggttccgga tccggctgtg tcgcccgtat cgggcccaga ccaaaggcaa
    17101 ggtcgagcgc ttcaatcgct acttccgcga gagcttctac aacccgttgc tgacccggat
    17161 gaagggcacg gggctgctgc tcgattgtgc tgctgccaac cgacgcgtcc gtgactggtt
    17221 ggcagacgag gcgaatgtgc gggtccacgc caccctgaac gagcgcccca tcgaccgttg
    17281 gcggcaggag cgggaacacc tgcaaccctt gccatcccgt gtgcggcgcg acgaggcccc
    17341 cctgctggat aacagtctcc gcccggtacc actggaatct ctccagcacc cactgtctgt
    17401 ctatgacgca attggggagg cctgccgatg aacctccagc atgagcggat cgacgccctg
    17461 tgccagcaac tcaaactcga acgggtggca acgcattacc ccgtcctggc gcagcaggcg
    17521 gtgcgcgagg acttcagctt caccgacttc ctggaacacc tgttgcggca tgaagcgggg
    17581 tgtcgccagc agcgcagccg cgaactgctg acgcggatgg cttgcttccc gggcatcaag
    17641 accctggagg actatgactt cagcttcaac cccggcgtgc ccaaggcact ggtgcaggag
    17701 ctgggcagtc tggcgtttgt cgaacgggcc gagaacgtgg tgctgatcgg accctctggc
    17761 atcggcaaga cccacctcgc catcgccttg ggttacaagg ccgcgcaagc cggggtcaag
    17821 acacgcttca tcacggcagc cgacctgatg ctgcaactga gcacggcgca gcgacaaggg
    17881 cggctgaagg aatacttcaa ccgcgccatc ctcggtccac ggctgctggt gatcgatgag
    17941 atcggctacc tgcctttcgg acgcgaggaa gcgaacctgt tctttcaggt ggtggcgaag
    18001 cgctatgaga aaggggcgat gatcctgacc tcgaacctgc cgttcagcca gtgggccgac
    18061 gcgtttgccg gcgataccac cctgacagcc gcgatgctgg atcggctgct gcaccatgcc
    18121 catatcctga ccctgagcgg cgaaagctac cgcttgaagg acaagaggaa ggcgggagtg
    18181 gtcaggaaaa attccaaacc cgaatgatcc aggtgggtca gtattacttt ggtgattcag
    18241 gggtaaagtg ggtcagtttt cagttggtgt tgacaccggc gtaccctcgg tgctatcttc
    18301 gcgccccaat agtcggggct tggccaggac ttcctgaggc cgtccgtaac gtggatgccg
    18361 aggtcaggcg aggtggccga cccatgaacg ccgacctgat tcgtttttca agctcggtga
    18421 taatcccagc tgtagcggcc tgattacatc cggccgctac acctagctcc accttcaaac
    18481 aaggaatatc gttgatgtca ctgtatcgcc gtctagttct gctgtcttgt ctctcatggc
    18541 cgctggctgg cttttctgcc accgcgctga ccaacctcgt cgcggaacca ttcgctaaac
    18601 tcgaacagga ctttggcggc tccatcggtg tgtacgcgat ggataccggc tcaggcgcaa
    18661 ctgtaagtta ccgcgctgag gagcgcttcc cactgtgcag ctcattcaag ggctttcttg
    18721 ctgccgctgt gctggctcgc agccagcagc aggccggctt gctggacaca cccatccgtt
    18781 acggcaaaaa tgcgctggtt ccgtggtcac ccatctcgga aaaatatctg acaacaggca
    18841 tgacggtggc ggagctgtcc gcggccgccg tgcaatacag tgataacgcc gccgccaatt
    18901 tgttgctgaa ggagttgggc ggcccggccg ggctgacggc cttcatgcgc tctatcggcg
    18961 ataccacgtt ccgtctggac cgctgggagc tggagctgaa ctccgccatc ccaggcgatg
    19021 cgcgcgatac ctcatcgccg cgcgccgtga cggaaagctt acaaaaactg acactgggct
    19081 ctgcactggc tgcgccgcag cggcagcagt ttgttgattg gctaaaggga aacacgaccg
    19141 gcaaccaccg catccgcgcg gcggtgccgg cagactgggc agtcggagac aaaaccggaa
    19201 cctgcggagt gtatggcacg gcaaatgact atgccgtcgt ctggcccact gggcgcgcac
    19261 ctattgtgtt ggccgtctac acccgggcgc ctaacaagga tgacaagcac agcgaggccg
    19321 tcatcgccgc tgcggctaga ctcgcgctcg agggattggg cgtcaacggg cagtaaggct
    19381 ctgaaaatca tctattggcc caccaccgcc gcccttgcgg gcggcatgga ttaccaacca
    19441 ctgtcacatt taggctagga gtctgcgcgg cagagccgtg tgaccggttt tctgtagagc
    19501 actgacgatg gcggcggcgc tctctgcaat tggcaaggcg tcggcgccaa ggataccaat
    19561 cttgcggcgc gcggcgtgtt atgacgactg gggtgcattt gagccgcccc atttaacctt
    19621 cgccctcaca gatacgccat tcgcctcaga tttagcgcca tgcagacgag cttccactcg
    19681 gcttgcacct tgtccaggcc cctcatgctg aactgacgca atcccatcac cgccttgatc
    19741 caaccattcg gagcctccac gatcgacttg cgccggcggt aagctgcatc gccttgctcc
    19801 gttttcaatt tcgccgcaat cgccgccgta tgcggatggg tcttggcatt gaccttggca
    19861 tcttcacgtc cctcgcggcc gagggcaacg atgacatcgc cgtggtgatc ggcgaccttt
    19921 gccagaacag cctcactacg gaatcccgca tccgccagcg tctgggccgg catttctccg
    19981 gtgttggcct gaactgctgc cagcatgccc agcagcgcct gactgtccgc ggcgcagttg
    20041 gtcaactccg ccgccacgat gatctggtgc tcggcatcga ccgctgtgta cccgttgtag
    20101 ctctgctcgg agccaccacc ggcgtgtttc atgatccggc tgtccggatc ggtgaagctt
    20161 tcctgatcac ggtcatccgg cacaccaaac tcgcgtttgt acgagccacc gcccttgtcc
    20221 gagccatccg gatggcgagg ccggcggcca tcgtcttcgc tgcgcccccg ggcctggtcc
    20281 gcttcacgct ggcgcgcttc caggcgcgcc tttgccgcct ggatcgcctc caggcgcttc
    20341 tcgcggcgag aaatctcggc aggaatgtcc agctccggct cgttacgctc ctggtcgtcg
    20401 gtagccttgg cgcgatcaag cagcgccttg atctcgcaat gcaattcgtc ctcggccggc
    20461 ttcatgcgct tatagctcat cgccttgtgg cggctggcgt tggcttttac cttggtgccg
    20521 tcgaccgcga tcgtgccaag cttcaccagc ccacattcgc gcgccagttg caccacctga
    20581 acgaacaaat tctcaagctc ggtcaggtgt agggcacgga agtcactcag cgtgcggtgg
    20641 gccgggaagt ttccagcggc cagcacacgc aacgcgacat cctcgtacag cttcctggct
    20701 agtttgcgcg aagagaagac gccgctcgcg taaccataga tcagcacttt gaccatcatc
    20761 gccggatgaa acggctgatt gcccggacca ccgccggcat accgggcgtg gaatgcgctc
    20821 aagtccagcg tatcgacagt ctcgctgatg aagtaggcaa gatgcccttc aggtagccac
    20881 tctcccagag aagggggcag cagataggat tggtcgggtc ggtaaggaag gtaactggca
    20941 gccatccccg tatcgtcctc gatcttccgc cgatttggct tctgccgcgc aggctcctag
    21001 gccaccgtag ctaaacatac gagaaaaacc gcttcttgag cgctctctga gaccaccttg
    21061 ccgacaacgc agaaacggtt gcggaaaaat cggcgtttcc ggcgtacgcc acccgacctg
    21121 gacgaactat tgcggacctg gaactggagt agcggaattc cccggggttt cagcgtcgcg
    21181 ccacagcgcc tcagatagat gcggtagcct ttggcgggtc gtcatgccgc ggaccacccc
    21241 cccaaaaaat tccacaatgc ggaatggcgg aattttctgg ggttcccgct taccccccct
    21301 acttcgacag cagatattta atttcatcga gcatcacgct gacgtgtggc cactcccgga
    21361 actcgtcccg cgcaatgatg atttgcgcgc agcgggcaaa cagcattttt tgcacacgga
    21421 tcaccgcctc gtcgtccatc gagccgataa cgtacaggca gccgccgccg ttgataatcc
    21481 ccgccacatc gatgccactg tccgtctgca ggacgctcag gtcagcgacg ttttccagcc
    21541 tagtgatcaa ccccttcacg tcctttttca gggcctccgg cagcgcgtac gccgccgcca
    21601 gcacctgctg aatgtttgcc ccctgcggaa actgctccgc aatcagcttc gccgctttct
    21661 gctcgctgat gcggtagtgg tccgccacgt cgccggtctc gcccaggtta agcccggcaa
    21721 tcagcaggtt tttcagcgcg tactggtcga gatcgcggaa cagattcagc tgcgccggtt
    21781 tccccggccg cagatccagc agggtgaagt ccggacagtg cgcccggaag acgtgcggcg
    21841 cccatgcgtc ccctttgggg tcgaagtaca ccaccgcgtc cccgaaatcg cgtacgcagc
    21901 gaatgagcgc gttggtggcc atcacgctct tgccgctccc gggcaggccg aggatctgaa
    21961 tgttggtctt gcgccaggta tcacgcggaa ccagcaccgg cttgccctgc tcatccttac
    22021 ccagaaacac cgcctgctcc tgccgggcct gctccgagga aaaatcggcc agcgcattaa
    22081 ccggtaccgg ctccccgaaa tgcaggtggc gcacgtcggt catctctcct gtccgctggc
    22141 tgctgcgccg gctctcctga ttcagtttcg cgttcaccgc ctcgtcagca gccgcaaaat
    22201 gaccgtcaag cagcaggaac gccagcagcc gcgccaacac aatcccgaca gccagcccgc
    22261 ccgcgcacca ggcaatcccg aacaggttag ccggctgcag caggtaataa tctgcgtttg
    22321 cgtagaggtc cggacgcagg acggtttctc cccagctctc gataaacacg gcgacaacca
    22381 gcccccccag aagggccaga ccggccgcgc cggtcagcca gtacgcgtag ttccagacat
    22441 gtcgacgtgc cctgaccatc cgcccgggcg aatccagcga ggccagcacc gaaaatggcg
    22501 ctggccgttt attatcgcgc ttatagcgat cggcatactc ccgtcgctcc ttatgactca
    22561 gccccacaaa acgcatccgt ccggcccaaa gttcagccag accgaaaaac aggccgataa
    22621 ctaggaaagc cccggccaga ccgtaatact cctggtacag ccagctgacc cacggataaa
    22681 tctgccgggc cagctccgga atgtgccact tccaggcaag cgaatccgta ttaaacatgt
    22741 tctctctcct tcagacgatg gtttgccggc gtgatgtgca gcccccgctg cacaagccgc
    22801 ggacatgccc caaggcatgg cggcggcggt cacgtccgtg gtgattgcgt tcagctttca
    22861 ccacggaggc cagcctcttt ccgccccatg cggaaaaggc gcagccccgg aggaacaacg
    22921 agcacgcccc agcgtgtgag aggaaaaggc ggcaccccag tgcggtcttt tccggtgttc
    22981 cggcccccgt cagagttcgc catagcgagc ggctgaccac ccgcaaaatc aggagcagct
    23041 ttgctgcttc gccaggtgcg tccagcaccg tggatttttg tgggtggtca ggcgtgagcc
    23101 tgacgggggc cgggtgaatt tctggcgtgg ccggcgtcca gccggacgga gccagaaaga
    23161 gggggagaga ccgtgcgtcg gtggcgtcca gccagcgtaa gcaggggata tccccctgag
    23221 gtcagccacg ccctcgcggg gatgacctgt atttctccgt aaggagaaaa aagcaacaga
    23281 gataggttaa cgtaaaatgt tcagcgaaaa accgatatga ttcacctatc ctggtaattt
    23341 attatcaggg aatataaaga cttaatcagg ggacaatatg ccacatcagc gcgtccggtg
    23401 tccgtcttgt aggtgccggg gaaattgcgc ctcctcgctc actcggtcgc tacgctccgg
    23461 ccgtgagact gcggcgggcg ctgcggacac atgcaaagtt acccacagat tccgtgaata
    23521 agcaggggac taacatgtga ggcaaaacgg caaggccacg caggtggcgt ttttccatag
    23581 gctccgccct cctgactgag ttcacataaa cagacgcttt ttcggtgcat ctgtgggagc
    23641 cggtggctca accatgaatc agtcaggagt ggcgaaaccc gacaggactt aaagatcatc
    23701 accgtttccg atgaatcgct ccctcttgcg ctctcctgtt ccaaccctgc cgt
//
