LOCUS       NC_009807              10066 bp    DNA     circular CON 27-JAN-2024
DEFINITION  Salmonella enterica subsp. enterica serovar Typhimurium plasmid
            pTPqnrS-1a, complete sequence.
ACCESSION   NC_009807
VERSION     NC_009807.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN14229598
KEYWORDS    RefSeq; delta res gene; mobA gene; mobB gene; mobC gene;
            mobilization protein A; mobilization protein B; mobilization protein
            C; qnrS1 gene; quinolone resistance gene; tnp gene; transposase;
            truncated resolvase, complete genome.
SOURCE      Salmonella enterica subsp. enterica serovar Typhimurium (Salmonella
            typhimurium)
  ORGANISM  Salmonella enterica subsp. enterica serovar Typhimurium
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Salmonella.
REFERENCE   1
  AUTHORS   Kehrenberg,C., Hopkins,K.L., Threlfall,E.J. and Schwarz,S.
  TITLE     Complete nucleotide sequence of a small qnrS1-carrying plasmid from
            Salmonella enterica subsp. enterica Typhimurium DT193
  JOURNAL   J Antimicrob Chemother 60 (4), 903-905 (2007)
   PUBMED   17652106
REFERENCE   2  (bases 1 to 10066)
  AUTHORS   Schwarz,S.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JUN-2007) Schwarz S.P., Molecular Microbiology and
            Diagnostics, Institute for Animal Science (FAL), Hoeltystr. 10,
            Neustadt-Mariensee, 31535, GERMANY
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/27/2024 13:38:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 14
            CDSs (total)                      :: 14
            Genes (coding)                    :: 10
            CDSs (with protein)               :: 10
            Genes (RNA)                       :: 0
            tRNAs                             :: 0
            ncRNAs                            :: 0
            Pseudo Genes (total)              :: 4
            CDSs (without protein)            :: 4
            Pseudo Genes (ambiguous residues) :: 0 of 4
            Pseudo Genes (frameshifted)       :: 1 of 4
            Pseudo Genes (incomplete)         :: 4 of 4
            Pseudo Genes (internal stop)      :: 1 of 4
            Pseudo Genes (multiple problems)  :: 1 of 4
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AM746977.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..10066
                     /organism="Salmonella enterica subsp. enterica serovar
                     Typhimurium"
                     /mol_type="genomic DNA"
                     /serovar="Typhimurium"
                     /isolate="P557570"
                     /sub_species="enterica"
                     /db_xref="taxon:90371"
                     /plasmid="pTPqnrS-1a"
                     /geo_loc_name="United Kingdom"
                     /note="definitive type, DT193"
     gene            join(9475..10066,1..>8)
                     /locus_tag="HXE83_RS00005"
                     /pseudo=""
     CDS             join(9475..10066,1..>8)
                     /locus_tag="HXE83_RS00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001493761.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="ISKra4-like element ISKpn19 family transposase"
                     /name="ISKra4-like element ISKpn19 family transposase"
     gene            complement(226..1119)
                     /locus_tag="HXE83_RS00075"
     CDS             complement(226..1119)
                     /locus_tag="HXE83_RS00075"
                     /inference="COORDINATES: protein motif:HMM:NF014763.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cache domain-containing protein"
                     /protein_id="WP_176453403.1"
                     /translation="MKMSDVMSNYIEIAQRELAYGAKKIESTNDIDSLKNEADRLRLQS
                     GMFNSVLVVSDGAVVLATSPESLGLVGVHLNSSASKLAIEAKKPFISAPYKSASGNLII
                     FLSHPIYDKNSNYIGYVGGSIYLKEQSLFSDVLSRHFFKSDTEISIVSDDGNVIFNNDN
                     SAVGRPMVMDDNLKSKLTSSERGEGIFFSSGNKYLLGYAHMKNTAWSVLVYSHADSVTT
                     ILITYAKSVLVLLIVIVITFSLFSYFIASRISIPLEKLAISTNAKDIGGSLVDIKGINA
                     WYVEADRLKKALFTHN"
                     /name="cache domain-containing protein"
     gene            complement(1619..1834)
                     /locus_tag="HXE83_RS00015"
     CDS             complement(1619..1834)
                     /locus_tag="HXE83_RS00015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MbeD family mobilization/exclusion protein"
                     /protein_id="WP_000137421.1"
                     /translation="MTELEKQLLSALEQLQQDYSKRLDEWENAFAEWRTMSGLMQRENA
                     ALSERVTGLSRQVQSLSEQLRRLSQG"
                     /name="MbeD family mobilization/exclusion protein"
     gene            complement(1838..2323)
                     /locus_tag="HXE83_RS00020"
                     /old_locus_tag="pTPqnrS1a_p2"
     CDS             complement(1838..2323)
                     /locus_tag="HXE83_RS00020"
                     /old_locus_tag="pTPqnrS1a_p2"
                     /function="involved in plasmid mobilization"
                     /inference="COORDINATES: protein motif:HMM:NF016710.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MbeB family mobilization protein"
                     /protein_id="WP_012002051.1"
                     /translation="MSSLLTLAKDLEQKSKAQQQSTGEMLKAAFSEHEQSVRAELNESE
                     KRISAAILDHDRKLSSAMSQRTKGMVRMVSQTWLTIVLVSVVLIASSAGILWWQSQQIL
                     DNYTTIREQKSTQAMLSERNSGVQLSTCGEQRRSCVRVNPEAGRFGEDSSWMILAGK"
                     /name="MbeB family mobilization protein"
     gene            complement(<2358..3062)
                     /locus_tag="HXE83_RS00085"
                     /pseudo=""
     CDS             complement(<2358..3062)
                     /locus_tag="HXE83_RS00085"
                     /inference="COORDINATES: protein motif:HMM:NF015397.4"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /name="relaxase/mobilization nuclease domain-containing
                     protein"
     gene            complement(3001..3324)
                     /locus_tag="HXE83_RS00030"
                     /old_locus_tag="pTPqnrS1a_p3"
     CDS             complement(3001..3324)
                     /locus_tag="HXE83_RS00030"
                     /old_locus_tag="pTPqnrS1a_p3"
                     /function="involved in plasmid mobilization"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000957083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="WP_012002052.1"
                     /translation="MLTIWVTEDEHRRLLDRCDGRQLAAWMRQTCLDEKPARAAKLPSI
                     SPALLRQLAGMGNNLNQIARQVNAGGGTGHDRVQIVAALMAIDAGLERLRHAVLEKGAD
                     DDR"
                     /name="MobC family plasmid mobilization relaxosome protein"
     gene            3974..4132
                     /locus_tag="HXE83_RS00035"
     CDS             3974..4132
                     /locus_tag="HXE83_RS00035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001396189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001658417.1"
                     /translation="MHEPPVQSDCCASSGNFQLDSNPERHDKAPLAAAIGNWELVDLDI
                     ESLEVVA"
                     /name="hypothetical protein"
     gene            complement(4375..4680)
                     /locus_tag="HXE83_RS00040"
     CDS             complement(4375..4680)
                     /locus_tag="HXE83_RS00040"
                     /EC_number="2.7.7.65"
                     /inference="COORDINATES: protein motif:HMM:TIGR00254.1"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA];
                     GO:0046872 - metal ion binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="WP_223229636.1"
                     /translation="MPKPDNSCCRSEDIVCRFGGEEFVVFLPNTSVVTAECVAERIRSV
                     IESTVFPNNLRVTVSAGVATQEDPLGGIDFLLKNADDALYQAKGEGRNKVIVYSAI"
                     /name="GGDEF domain-containing protein"
     gene            complement(<4666..5696)
                     /locus_tag="HXE83_RS00045"
                     /pseudo=""
     CDS             complement(<4666..5696)
                     /locus_tag="HXE83_RS00045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612174.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /name="IS3 family transposase"
     gene            6092..6748
                     /locus_tag="HXE83_RS00050"
                     /old_locus_tag="pTPqnrS1a_p6"
     CDS             6092..6748
                     /locus_tag="HXE83_RS00050"
                     /old_locus_tag="pTPqnrS1a_p6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001516695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quinolone resistance pentapeptide repeat protein
                     QnrS1"
                     /protein_id="WP_001516695.1"
                     /translation="METYNHTYRHHNFSHKDLSDLTFTACTFIRSDFRRANLRDTTFVN
                     CKFIEQGDIEGCHFDVADLRDASFQQCQLAMANFSNANCYGIEFRACDLKGANFSRTNF
                     AHQVSNRMYFCSAFISGCNLSYANMERVCLEKCELFENRWIGTNLAGASLKESDLSRGV
                     FSEDVWGQFSLQGANLCHAELDGLDPRKVDTSGIKIAAWQQELILEALGIVVYPD"
                     /name="quinolone resistance pentapeptide repeat protein
                     QnrS1"
     gene            complement(7067..7681)
                     /locus_tag="HXE83_RS00055"
     CDS             complement(7067..7681)
                     /locus_tag="HXE83_RS00055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017412822.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_014839983.1"
                     /translation="MFIGYIRMSKADGSQTNDLQRDALIAAGVDAAHFYEDRASGKREE
                     RPGLTACLKALRPGDTLVVWKLDRLGRDLRHLINTVHDLTARGTGLKVLTGHGATIDTT
                     TAAGKLVFGIFAALAEFERELIAERTTAGLASARARGRNGGRPYKMTPVKLRLAMASMG
                     QSETKVSTLCQELGITRQTLYRHISPVGQLRADGIKLFNRG"
                     /name="recombinase family protein"
     gene            7843..>8025
                     /locus_tag="HXE83_RS00060"
                     /pseudo=""
     CDS             7843..>8025
                     /locus_tag="HXE83_RS00060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015060658.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4158 domain-containing protein"
                     /name="DUF4158 domain-containing protein"
     gene            8161..8706
                     /locus_tag="HXE83_RS00065"
     CDS             8161..8706
                     /locus_tag="HXE83_RS00065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001493763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid pRiA4b ORF-3 family protein"
                     /protein_id="WP_001493763.1"
                     /translation="MVWRRLRIAADTSLAALHFIFQIVQGWGDDHLHQFHIYGKDYGIS
                     YEGGIGFVDNPFRVVIDDFAFDAGDRFTYEYNFFEHWLHDIRVEAIYENSTLKAPFCIS
                     GHGMPGATAADEFDKTLAFLEAIVNADDETTVGEIRPFADDLDAVRFNRHKINRQLSRL
                     DLASPVLEPEVIWLGRRR"
                     /name="plasmid pRiA4b ORF-3 family protein"
     gene            8843..9415
                     /locus_tag="HXE83_RS00070"
     CDS             8843..9415
                     /locus_tag="HXE83_RS00070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001493762.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001493762.1"
                     /translation="MQYAYIRVSSADQNTARQEEALSKAGFQPDKICVEHASAKDTNRP
                     GLQELLGQLRPGDTLLVHSIDRLCRNMSDMCAVTTRLRDQGVTLIFLKEQLTFSAGTNN
                     PMQELQLHMMSAFSQFERALLKERQADGIAAKKARGEKTGRPGADIKKIQEIDALRSRG
                     VRLRIACDHAGLGVSTYYKLRHQMNNQ"
                     /name="recombinase family protein"
     ARG             6093..6745
                     /name="qnrS1"
                     /gene="qnrS1"
                     /gene_name="quinolone resistance pentapeptide repeat
                     protein QnrS1"
                     /tool="amrfinderplus"
                     /drug_class="QUINOLONE"
                     /identity="100.0"
                     /coverage="100.0"
     Typing          3595..4141
                     /name="rep_cluster_2335"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="91.652"
                     /coverage="90.0"
                     /evalue="0.0"
     Typing          complement(1516..3011)
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="91.383"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aattaataac ctgagccaaa gtaacaagaa cctcatctcc gaccccatgc ccgaagttat
       61 catttatttt tttaaaaaaa tcaacatcaa tagcaataac tgaaacccct gaaccctgct
      121 tgtgattttg tattttattt tgaaaacccc agtctgttgt tcacgccggt taggggatct
      181 ttaagcgcca cctcatttag agaatcaact ctttctatca ttatcttaat tatgcgtaaa
      241 aagtgccttt tttagtcggt cggcttcgac ataccaagca ttgatacctt taatatcaac
      301 tagcgaaccc cctatatctt tagcattggt agatatagca agcttttcta aaggaattga
      361 aatacgggaa gcaatgaaat atgaaaaaag tgaaaatgta ataactatta caattagcag
      421 aacaagtaca ctcttagcat aagtaataag aatagtagtc acgctgtcag cgtgactata
      481 aaccaacaca ctccaagcag tatttttcat atgagcataa ccaagaagat atttattccc
      541 cgaagaaaaa aagataccct cacctctctc agacgaagtt aacttcgatt tcaaattatc
      601 atccataacc attggtcgac caacagcact gttatcgtta ttaaagatca catttccatc
      661 atcactaaca atgctaattt cagtgtcgct tttgaaaaaa tgcctgctca aaacgtcgct
      721 aaataaactc tgttccttta gatatataga cccgccgaca taccctatat aattactatt
      781 cttatcataa ataggatgtg acaaaaaaat aatcaaattc ccagaagctg atttgtaagg
      841 tgccgatata aatggttttt tagcctcaat cgccaactta ctggcacttg aattcaagtg
      901 aactccaact aaaccaagtg attctggcga agtcgccaga acaacagcac catcactaac
      961 aacaagaact gaattaaaca taccagactg caatcttaac ctatccgcct catttttaag
     1021 tgagtcaata tcattagttg actctatttt ttttgcgcca tacgccaatt cacgttgagc
     1081 aatttcaata taattactca ttacatctga cattttcata gcgtacgatg aattagcatc
     1141 aagcaagtct ttttctatat tttcgcgttt aaaaccataa taacgacaat cagaaaaata
     1201 gaagtcaaca aaataccacc aacggacaag gttatgacta tcggacgaag gtgaggcttt
     1261 ttaattctca taaaaataca ctctatataa ttaaaaaatt ccacatttac cataacatcc
     1321 cttgcccgca ccgccccgga cgggttcggc gcgaatgcgg cgtcagcccg gtaaaaccgg
     1381 cagtaaactc cccgctaaac cgcgcttttt gagccagata aatttcccca agatgcatag
     1441 ccatgcagcc ggggggatgg caccgccttt cggcggggat ctgcgccgaa agacccgttt
     1501 tatccggttt gttacagcga cggaccgttg tacgtccgct ggcgctgcga tcgttccagc
     1561 tccagcgctt tccggtgctg cgccgcccgt tcctgctccc ggtgcgcctc gataccattc
     1621 agccttgcga caaccggcgc agctgctcgc tcaaactctg cacctgcctg ctcaagcccg
     1681 tgacgcgctc gctcagcgcc gcgttctccc gttgcataag accagacatc gtccgccatt
     1741 ccgcgaaggc gttctcccac tcgtccagcc ttttcgagta gtcctgctgt agctgctcta
     1801 atgcgctcag caactgtttt tccagctccg tcatgtgcta tttccccgcc agtatcatcc
     1861 agctcgaatc ctctccgaac cgtcccgctt ccgggttcac cctcacgcag ctgcgtctct
     1921 gctcgccgca ggtcgagagc tgcacgccgc tgttccgctc ggacagcatc gcctgcgtgc
     1981 tcttctgctc ccggatggtc gtgtaattgt cgagtatctg ctgactctgc caccacagaa
     2041 tgcccgcgct cgatgcgatc agcacgacgg aaaccaggac gatggtcagc cacgtctggc
     2101 tgaccatacg caccatgcct ttcgtgcgct ggctcatggc tgaggacagc ttccggtcgt
     2161 ggtcgaggat ggcggcgctg attctcttct cgctttcgtt cagttccgct ctgacagact
     2221 gctcgtgctc gctgaatgcg gctttcagca tctcgccggt actctgctgc tgcgctttcg
     2281 atttctgctc taagtccttc gccagcgtta aaagactgct catagatggc tccctttagt
     2341 cggatgtttc gccccccgtc cgggtcggca atgctgatac tacttttcgt ggtgcgtacc
     2401 acctcaaaac ccgcgttttc cagcgcctca gtaacgtcct gacgggtttt cagctccccg
     2461 gacgaggcta aggccagcaa accccgggtg atcgcctgag ctgcctcctg cttcgtttcc
     2521 ggcagcgcgg acggcgtgac cagcgcccgc cggttttccg gcgcattcgg gtcgtgcagc
     2581 cccagcctgc cgttcacgat ggtctgccag gcatcgatgc gcggacggtc agcgcggtcg
     2641 taatacggct ggagcctttt gccggtcagc agctccgtgt tcgggatcag gaagttcagc
     2701 tccagccgcc ccttgtcctg gtgctccacc cacagcacgc tgtactggtc tttatcgagt
     2761 ccgggcatca gaacacgctc gaagctcgcc atcagttttt cacgctgact gggcggtaag
     2821 tcctgttcgg caaacgacag caccccggag gtgtactttt tggcgtaggg cgaggcgtcg
     2881 attagctccc ggacttcctc cggtttaccc tgcagaacgc tggcgccgtc gcgcttgcgg
     2941 tcattaccca gcagataatc caccggaccg gcaccgccgc cgcgccctcg tgggtgaaat
     3001 ttaacgatca tcgtcagccc ccttttccag cacagcgtgc cgcaggcgct caagtccggc
     3061 atcaatggcc atcagcgcag cgacaatctg tacgcgatca tgtccggtac caccaccggc
     3121 gttaacctgc cgggcaatct gattgaggtt gtttcccata ccggcaagtt gacgaagcaa
     3181 cgccggcgag atcgacggaa gtttggcggc acgagcaggt ttctcgtcga gacacgtctg
     3241 ccgcatccag gccgcgagct gtctaccgtc gcagcgatcc agcagacgcc ggtgctcgtc
     3301 ttcagttacc catatcgtga gcattttgct gcgtttgtct gccaatccgg cctcctgata
     3361 acgccgggac ggacggggaa ttatttcccg gtcggcgcgg tgttggacaa gccgcaggcg
     3421 cgtcagtgcc ttttagcggg tttcggggcg cagccctgaa ccagtcacgt agcgctagcg
     3481 gagtgtatac tggcttaaaa tgtaacatcg cagaaacatc aagcatagct gccacataaa
     3541 gcaggtgaaa aatgagattc gtatgcgtca gcagaagatg cactgccgga gaaatgccgc
     3601 ttcctcgctc actgactcgc tccgctcggt cgttcggctg cggcgagcgg taccggctta
     3661 cgggcggggc ggaaatttcc tggaagatgc taggaagaaa cttaacaggg aagcgataag
     3721 gccacggcag agccgttttt ccataggctc cgcccccctg acaagcatca cagaatctga
     3781 cgctcaaatc agtggtggcg aaacccgaca ggactataaa gatcccaggc gtttccccct
     3841 ggtagctccc tcgtgcgctc tcctgttcct gcctttcggt ttaccggtgt cattccgctg
     3901 ttatggccgc gtttgtctca ttccacgcct gacactcagt tccgggtagg cagttcgctc
     3961 caagctggac tgtatgcacg aaccccccgt tcagtccgac tgctgcgcct cctccggtaa
     4021 ctttcaactt gattccaacc cggaaaggca cgacaaagcg ccactggcag cagccattgg
     4081 taactgggaa ttagtggatt tagatatcga gagtcttgaa gtggtggcct gactacggct
     4141 acactgaaag gacagtattt ggtatctgcg ctccactaaa gccagttacc ttcggaagaa
     4201 agtgttggta gctcttaatt ccggcaaacg aaccaccgtt ggtagcggtg gtttttttgt
     4261 ttacagggca tgagcttacg acgacatcga agggataaca agaggatccg cttcttgaac
     4321 ccttttcccc acaaaaaaac gccacactag cgcgtaaagc gtcatcaaaa aaactcaaat
     4381 agcgctatat acaatcactt tattacgccc ctctcccttg gcttgataaa gagcatcatc
     4441 agcatttttc agcaaaaaat cgatcccacc aagaggatcc tcttgtgttg ccacaccagc
     4501 agagacggtg acccgcaagt tattagggaa aacagtactt tcaataacac tcctaatacg
     4561 ctccgcaaca cactccgctg ttaccacaga tgtattcggc agaaaaacaa caaactcttc
     4621 tccaccaaac cgacaaacaa tatcttcact acggcagcaa gaattatccg gtttcggcat
     4681 gatgctgatg tagtcccgtt ttatcgtcat cacgaagctt tctgctatgc cattgctttc
     4741 cgggcttcgc actgctgtcg tacaaggctc cagtcccagc aaccgggcga acgccggcac
     4801 tgttggcaac tgccttccga agcgtttttc caccgcaccc agcatgacat cctgcaccgt
     4861 ttctttgtca tagcctccgg tgctcgctgc ccaatcaatg atctccctgt cgcagcagtc
     4921 ctgcgcgaag gtcacccgca gcttttcgcc attatcacag cggaactcaa agccatctga
     4981 gcaccagcgc cggttacttt ccgctactgc tacgcgcccc ttatgggccc gcttacggca
     5041 aggatcagcg ggtttacgtt caagaagcag attatgcgtt ctcataatgc gatacacccg
     5101 ctttgcatta accacaggca ggccgtcccg ctccgactcc cgtcgcagca gcgcccacac
     5161 acggcgataa ccatacgtcg gcaggtcagc caccgccatg tttatccggg acaatacggt
     5221 ggtatcgtca gaacggggct gccgtctgcg atcctgtcag tcagatggcc ggtgaacccg
     5281 aatgctcaac tgcgcacgcg acacgccaag acttctgcaa acgtcgctta ttcgtcgttc
     5341 ccaggcaacg agggcgcatg cgcaatccat ttttttgccc ggccgaactc cacggcctct
     5401 ttgagtatct cggcttccat cgtctttttg cccagaaggc gctggagttc gcgaatttgc
     5461 ttattggcgg cagcgagttc ggaggccggc accacttcct cgcccgatgc aacagccgtc
     5521 agtgaaaccg tcttatattg cttgcgccat ttgaatatct ggtttgcatt gatgccatgc
     5581 aggcgcgcga catgagacac ggtcataccg ggctccatag tctgctgaat aatggcaatt
     5641 ttttcctgcg gtgtacgacg ccgacgccgc tcaggtcctg ataacacttc aaccatctta
     5701 tcgttctgac tggtattaaa catagttccc aagactacct cttattttaa gagagtcgaa
     5761 gtgtctggtg atctatgggg ccagtctagc cctcttccaa gtgtagggag atatagtcaa
     5821 agtttgcttc tccgccgatg agtccgccct gcgtcggata gtccgatttt ttaccggcga
     5881 agcacggctc tcctaaccct atctaaagcg aataactttt ttcaacaggg ccgcgtgcca
     5941 atgcaagagc gataggcgct ctacgcgcca atttgaccac ttaaaacagg taaattgagg
     6001 ggttgtaatg tgttgatgta acaggctttt attttaatgt cttggcatat gtataatggt
     6061 agtctagccc tcctttcaac aaggagtact catggaaacc tacaatcata catatcggca
     6121 ccacaacttt tcacataaag acttaagtga tctcaccttc accgcttgca cattcattcg
     6181 cagcgacttt cgacgtgcta acttgcgtga tacgacattc gtcaactgca agttcattga
     6241 acagggtgat atcgaaggct gccactttga tgtcgcagat cttcgtgatg caagtttcca
     6301 acaatgccaa cttgcgatgg caaacttcag taatgccaat tgctacggta tagagttccg
     6361 tgcgtgtgat ttaaaaggtg ccaacttttc ccgaacaaac tttgcccatc aagtgagtaa
     6421 tcgtatgtac ttttgctcag catttatttc tggatgtaat ctttcctatg ccaatatgga
     6481 gagggtttgt ttagaaaaat gtgagttgtt tgaaaatcgc tggataggaa cgaacctagc
     6541 gggtgcatca ctgaaagagt cagacttaag tcgaggtgtt ttttccgaag atgtctgggg
     6601 gcaatttagc ctacagggtg ccaatttatg ccacgccgaa ctcgacggtt tagatccccg
     6661 caaagtcgat acatcaggta tcaaaattgc agcctggcag caagaactga ttctcgaagc
     6721 actgggtatt gttgtttatc ctgactaatt gctttgatgt gtgattttaa acgctcaaat
     6781 ttataaaacg aataatattg tcaaccttgc aataatagac atagggacaa ccatgtataa
     6841 atttttaccc tcaggcgtct tcacaataga gccatatagc agtgggtcac ttagtgggct
     6901 taatttttcc attaaagata atattaatat tgctcagtat aaaacatcat atggtagccc
     6961 atcttggcaa gtaaacataa ggctgccatt tataaggcac tgttgcaaaa atgtggaggt
     7021 gataggggta ctacgccgga accccagatt tttccgtccg ttcaaattat ccacggttga
     7081 acagcttgat cccgtccgcc cgcagttgac caacagggga aatatgcctg tacaaagttt
     7141 gccgggttat cccaagttcc tggcatagcg tactgacctt tgtttctgat tgtcccattg
     7201 atgccattgc cagtcgcagt ttgactggcg tcattttata aggtcggccg ccgttccgcc
     7261 cacgggctct tgctgatgcc agacctgcag tcgttctttc agcaatcagt tcgcgctcaa
     7321 actccgccag tgcggcaaag ataccgaaga caagcttgcc agcggccgtt gttgtgtcga
     7381 tagtcgcccc gtgaccggtc agcactttca gaccggtccc cctcgcggtc aggtcgtgca
     7441 ctgtattaat gagatgacga agatcacgac cgaggcggtc cagcttccat acgaccagcg
     7501 tgtctccggg tcgtagtgct ttcagacagg ctgtaagtcc aggacgctct tctcgtttgc
     7561 ccgatgcccg gtcctcataa aaatgtgcgg catcaacacc tgcggcgatc agtgcatcac
     7621 gttgtaaatc attcgtctgc gaaccatcag cttttgacat ccgaatatat ccgatgaaca
     7681 tatttcctct gtcacatata cgttcgatta tgtgacattc tgatttgggt accataatct
     7741 gtcaacggta gtcacattac ccgtaattta aattatgaca cgtaaaggtt ctatgttaat
     7801 gataatgtga caagcgcgtt taaataggca taaggatcag agatgcctac taaaaataag
     7861 ctcctcagta ttctttcgga cgccgagcag gaagcgctct atggtctacc tgatttcgat
     7921 gatgcacagc ggctggagtt tctggcgctg aatggatatg aactggcgct ggcctgcagt
     7981 cgccgggggc ttcacgctca aatttattgc atcatccaga tcggagagca tgaaaaacct
     8041 cggggcagcc atcgaatgat gccatctaca ggggttaaaa taaccaccat catttcataa
     8101 caatacctgc tgactatgaa gatctacgtc atcaaaatag cagttcatgg agtcagtccg
     8161 atggtctggc gtcggctgag aattgctgcc gacacgtcac tggccgcgct tcacttcatt
     8221 ttccagatag tgcagggctg gggggacgac catctccatc aatttcacat ttatggcaaa
     8281 gattacggta tctcctacga aggaggcatc ggttttgtcg ataatccgtt ccgggtcgtg
     8341 attgatgatt ttgcttttga tgctggcgat cgctttacct atgaatacaa tttctttgag
     8401 cactggcttc atgacattcg tgttgaggcc atttatgaaa actctacgct gaaagcgccg
     8461 ttttgtataa gcggccatgg tatgcccgga gccacagctg cggatgagtt cgataaaacc
     8521 ctggcgtttc ttgaagctat cgttaatgcg gatgatgaaa caacggtcgg cgagatccgc
     8581 ccttttgctg acgacctgga tgctgtcagg ttcaaccgcc acaaaatcaa ccggcaactg
     8641 agcaggctcg accttgcatc tccggtactg gagcctgaag ttatctggct gggccgtcgt
     8701 cgctgactga tgtctataaa ggtatacgtt ttcagcatgc ctctcagatc cccgaaaaaa
     8761 tgtctataaa cctccctaaa tcagtgttta tggattattc tttaaatctc tatgatgttt
     8821 aaagaccttc cggaggtttt gcgtgcaata tgcctacatc agggtaagct cggccgatca
     8881 gaatacggcc cgtcaggaag aggcattgtc aaaggcgggt tttcagcctg ataaaatttg
     8941 tgttgagcat gccagcgcga aggacacaaa ccgcccgggg ttacaggaac tcctggggca
     9001 attacgccct ggtgatacgc ttctggttca ttccatcgat cgcctttgcc ggaatatgtc
     9061 ggatatgtgc gctgtcacca cccggcttcg tgaccagggc gttaccctta tttttctgaa
     9121 agagcagctg acgttcagcg ccggcacaaa caatccgatg caggaactgc agctgcacat
     9181 gatgtcggca ttcagccagt ttgaacgagc cttactgaag gaaaggcagg ccgacggcat
     9241 cgccgcgaaa aaagcacggg gtgaaaaaac agggcgcccc ggcgccgata tcaaaaagat
     9301 ccaggaaatt gacgcactca gaagcagagg ggtcaggctc aggatcgcct gcgaccatgc
     9361 gggccttggc gtttccacat attataagct tcgtcaccag atgaacaacc agtagccggg
     9421 agatagtcat ccaccacagc aggaggcaat gatgcaactg acgctccaga tcaactgacg
     9481 ctccagatag tcatcaccga tgaatcaggc tccagtcgaa cggaggaact gatgacaatc
     9541 cagaaatcag gggagacccg gaacgacatc ggattatcgg tgtcagaatc caagctgttg
     9601 ctgaatacgg tccagcagtc ggtggtccag ctgcaggcag acgaatatac tcaacaccat
     9661 atccggtgcc ctcactgcct tgctgcgcgc agaatcaaag gcaaacagaa aatacggtac
     9721 cggacgctgt ttggcgttat tccggtatcc gggcttcggg tgtaccggtg ccgttgtgaa
     9781 gagagtgata caaagacagt cagtttgctc agcgactggg ccggcgatta ttctcacccg
     9841 gcactgaaat atattgaaac ccgctgggcc tcgatgatct cctatgaaat gacgactcgt
     9901 ctgctgaaag atattctgcc ggtgggccac agcctgaatg cctcaacggt gaggaatcat
     9961 ttatgccagg tggcgcagcg tcttgacgct gaggctgaag ctcattcagg ttttctttcc
    10021 ggctgccccc gcgactgggg gaacctgccc aggccaggaa aaccgc
//
