LOCUS       NC_009344               8953 bp    DNA     circular CON 27-MAR-2024
DEFINITION  Shigella dysenteriae Sd197 plasmid pSD197_spA, complete sequence.
ACCESSION   NC_009344
VERSION     NC_009344.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN02603600
            Assembly: GCF_000012005.1
KEYWORDS    RefSeq.
SOURCE      Shigella dysenteriae Sd197
  ORGANISM  Shigella dysenteriae Sd197
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Shigella.
REFERENCE   1  (bases 1 to 8953)
  AUTHORS   Yang,F., Yang,J., Zhang,X., Chen,L., Jiang,Y., Yan,Y., Tang,X.,
            Wang,J., Xiong,Z., Dong,J., Xue,Y., Zhu,Y., Xu,X., Sun,L., Chen,S.,
            Nie,H., Peng,J., Xu,J., Wang,Y., Yuan,Z., Wen,Y., Yao,Z., Shen,Y.,
            Qiang,B., Hou,Y., Yu,J. and Jin,Q.
  TITLE     Genome dynamics and diversity of Shigella species, the etiologic
            agents of bacillary dysentery
  JOURNAL   Nucleic Acids Res 33 (19), 6445-6458 (2005)
   PUBMED   16275786
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8953)
  AUTHORS   Yang,J., Yang,F., Chen,L. and Jin,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-MAR-2007) State Key Laboratory for Moleclular Virology
            and Genetic Engineering, Microbial Genome Center of Chinese Ministry
            of Public Health, 100 YingXin Street, XuanWu, Beijing 100052,
            P.R.China
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000012005.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 01:19:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,868
            CDSs (total)                      :: 4,755
            Genes (coding)                    :: 3,662
            CDSs (with protein)               :: 3,662
            Genes (RNA)                       :: 113
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 84
            ncRNAs                            :: 7
            Pseudo Genes (total)              :: 1,093
            CDSs (without protein)            :: 1,093
            Pseudo Genes (ambiguous residues) :: 0 of 1,093
            Pseudo Genes (frameshifted)       :: 382 of 1,093
            Pseudo Genes (incomplete)         :: 683 of 1,093
            Pseudo Genes (internal stop)      :: 260 of 1,093
            Pseudo Genes (multiple problems)  :: 213 of 1,093
            Pseudo Genes (short protein)      :: 4 of 1,093
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP000640.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..8953
                     /organism="Shigella dysenteriae Sd197"
                     /mol_type="genomic DNA"
                     /strain="Sd197"
                     /serotype="1"
                     /db_xref="taxon:300267"
                     /plasmid="pSD197_spA"
     gene            join(8756..8953,1..147)
                     /locus_tag="SDY_RS24195"
     CDS             join(8756..8953,1..147)
                     /locus_tag="SDY_RS24195"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein TraD"
                     /protein_id="WP_001188542.1"
                     /translation="MQREKTPEWREKQKISRGIRRGQGYRLVFQFPIRQAEKRAEAKAA
                     RKARDHALYQSAGLLIMAGLVDSQTGKPVDDPAKLLGALVSLHELSRDNPKWEEWKLKG
                     QVLLNQKKED"
                     /name="conjugal transfer protein TraD"
     gene            741..1697
                     /locus_tag="SDY_RS24200"
                     /old_locus_tag="SDY_PA01"
     CDS             741..1697
                     /locus_tag="SDY_RS24200"
                     /old_locus_tag="SDY_PA01"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001293214.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_001293214.1"
                     /translation="MSELVVFKANELAVSRYDLTEHETKLILFCVAKLNPTIENPTRDE
                     LTVKFSCSEYARTMGLSYENAWGRLNSATSDLFKRSVELIYPTGAVSKRIFNWTEYAEF
                     NREEQTVTLVFSSYIQPLLFHLKKFIKYNLEHVKAFENKYSMRIYEWLLKELSQRKTHR
                     GNIEISIKEFKFMLMLEKNYPLYAELNRWILKPVTNDLNTYSNMKLTIEKRGRPADTLI
                     FQVELDKQIDLVTELAKDPASKKEDKTIRLTPENRLHEGLKTTLHDALTAKIQLTSFEA
                     KFLSDMQSKYDLNGSFTWLTQKQRTTLEKILAKYGRI"
                     /name="replication initiation protein"
     gene            1705..2022
                     /locus_tag="SDY_RS24205"
     CDS             1705..2022
                     /locus_tag="SDY_RS24205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003799052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001229902.1"
                     /translation="MALVSVTEAARLTGKNRAIIHRYIKQGKLSQISDATNTKKVDTSE
                     LIRVFGSLTATHATLSQSDAMQHDATPKTDQSVALLQQKIALLEQLLESKNNELQRQDE
                     R"
                     /name="hypothetical protein"
     gene            2073..2770
                     /locus_tag="SDY_RS24210"
     CDS             join(2073..2322,2322..2770)
                     /locus_tag="SDY_RS24210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001743396.1"
                     /ribosomal_slippage=""
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1 family transposase"
                     /protein_id="WP_238386298.1"
                     /translation="MASVSINCPSCSATDGGVRNGKSTAGHQRYLCSHCRKTWQLQFTY
                     TASQPGTHQKIIDMAMNGVGCRATARIMGVSLNTILRHFKKLRPQSVTSRIQPGSDVIV
                     CAEMDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIW
                     MTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVI
                     GHYLNIKHYQ"
                     /name="IS1 family transposase"
     gene            complement(2979..4112)
                     /locus_tag="SDY_RS24215"
                     /old_locus_tag="SDY_PA04"
     CDS             complement(2979..4112)
                     /locus_tag="SDY_RS24215"
                     /old_locus_tag="SDY_PA04"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_000703236.1"
                     /translation="MKISIIGNTANAMILFRLDLIKTLTKKGISVYAFATDYNDSSKEI
                     IKKAGAIPVDYNLSRSGINLAGDLWNTYLLSKKLKKIKPDAILSFFSKPSIFGSLAGIF
                     SGVKNNNAMLEGLGFLFTEQPHGTPLKTKLLKNIQVLLYKIIFPHINSLILLNKDDYHD
                     LIDKYKIKLKSCHILGGIGLDMNNYCKSTPPTNEISFIFIARLLAEKGVNEFVAAAKKI
                     KKTHPNVEFIILGAIDKENPGGLSESDVDTLIKSGVISYPGFVSNVADWIEKSSVFVLP
                     SYYREGVPRSTQEAMAMGRPILTTNLPGCKETIIDGVNGYVVKKWSHEDLAEKMLKLIN
                     NPEKIISMGEESYKLARERFDANVNNVKLLKILGIPD"
                     /name="glycosyltransferase family 4 protein"
     gene            complement(4330..4920)
                     /locus_tag="SDY_RS24220"
                     /old_locus_tag="SDY_PA05"
     CDS             complement(4330..4920)
                     /locus_tag="SDY_RS24220"
                     /old_locus_tag="SDY_PA05"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: protein motif:HMM:NF025025.4"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_011898198.1"
                     /translation="MKNHKVSIIIPCFNNGKTIERCVLSALKQTHRNIEIICINDGPSD
                     NSWNILKKLSSLYGNVFAFNNEDNSGPSFSRIKGVSLSTGHFLSFLDADDYWHPKKLEL
                     QLSFINDENLDFLGSTCSIGEKNNQEINQGIKKEHLKLKIISFNMMLFKNYFQTPAVIM
                     KRDIFIPFNENQRFSEDYMSWLVIVYNKKTNVD"
                     /name="glycosyltransferase family 2 protein"
     gene            complement(5080..5385)
                     /locus_tag="SDY_RS25320"
     CDS             complement(5080..5385)
                     /locus_tag="SDY_RS25320"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000624216.1"
                     /translation="MISLAMSFVVMKNIPAVVTENNGASFVTEPNITERIVSKASDSDR
                     IARFKNAIVEISNLKTMFIGNGIGYSTLTQDPHNFYLSTIIDSSILILAIVMMVLY"
                     /name="hypothetical protein"
     gene            6383..6907
                     /locus_tag="SDY_RS25325"
     CDS             6383..6907
                     /locus_tag="SDY_RS25325"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_238386297.1"
                     /translation="MKKIVGRKYGKYISQISTDVFLAKITLSIIPIILALPLIYTTSSG
                     ISIPNNWFVWLILFILSFGFTPFWYYISIENIIPPAILDLLLRVTGLILIVIFVNSPSD
                     AKTTIAIQSMVGALNTLISTAVVFYLSGVGAINIKRALNEIKDGFSVFLYKSSQGIMIT
                     MSSSLLVFLGG"
                     /name="hypothetical protein"
     gene            7083..>7148
                     /locus_tag="SDY_RS24235"
                     /pseudo=""
     CDS             7083..>7148
                     /locus_tag="SDY_RS24235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012477181.1"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS1 family transposase"
                     /name="IS1 family transposase"
     gene            7225..7497
                     /locus_tag="SDY_RS24240"
                     /old_locus_tag="SDY_PA07"
     CDS             7225..7497
                     /locus_tag="SDY_RS24240"
                     /old_locus_tag="SDY_PA07"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_145811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000019161.1"
                     /translation="MSHNLEHQKVHTRMVKEVLKAVARANNHPYQSVFTDFIAGHPSCT
                     VCFWETFHKMSPDSPYEYVTFCHTCRRFDLYETEAEMKADDPKWW"
                     /name="hypothetical protein"
     gene            7478..8686
                     /locus_tag="SDY_RS24245"
                     /old_locus_tag="SDY_PA08"
     CDS             7478..8686
                     /locus_tag="SDY_RS24245"
                     /old_locus_tag="SDY_PA08"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000198547.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS91 family transposase"
                     /protein_id="WP_000198563.1"
                     /translation="MTRSGGDFQPRPLKRLFTTNQCWTSFLDASGLRDIEVEAVTKMLA
                     CGTRILGVKEYNCDKPECPHVRYVTNSCGSRACPSCGKKATDLWIATQLNRLPDCDWVH
                     LVFTLPDTLWPVFESNRWLLNDVCRLAVENLLYAARKRGQEPGIFCAIHTYGRRLNCHP
                     HVHVSVTCGCLNKHGQWKKLSFLKDAMRSRWMWNMRQLLLKAWSEGLAMPESLSHITTE
                     SQWRSLVLKAGGKYWHVYMSKKTAGGRNTARYLGRYLKKPPIAASRLAHYNGGASLSFR
                     YLDHKTGETAMETLTQRELVARLKQHIPEKFFKMVRYFGFLANRVCGEKLPQVYRALGM
                     DKPAPVAKVCYAQMVKQFLSRDPFECVLCGGRMVYRRAIAGLNVEGLKKNARDISLLRY
                     MPA"
                     /name="IS91 family transposase"
     Typing          742..1697
                     /name="rep_cluster_1155"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 gacagtcaaa cgggtaaacc ggtagatgac cccgcaaaac tactgggtgc attagtcagc
       61 ttgcatgaat tatcccgtga taatcccaaa tgggaagaat ggaaattgaa ggggcaggta
      121 ttactcaatc agaaaaagga agattagagc acagtgttaa taccctctaa aacgccacag
      181 aaagtccgtg gcgaggtttt gttggttcga taatggaatt tatcacctaa tactgaaaac
      241 atggcacaga agagcaaaca accaccttcc tgattgagcc gtgagcgaag cgaacccaat
      301 gacacgaaaa aaacagcggc gctgtggctg gatggtcgga gacaaaagaa aggggcagcg
      361 cgttgtccga gcaaagcgag ggagctactg aggtgtttta ggtttgtctt gaaaaggagc
      421 aaacgttgtt tgcgacatcc ttttaactac ggcaaatcga cggcaatttt ctgatttatc
      481 cacagggctg ggatctattc tttttttatc tcttattctt tctttattct aatgatttta
      541 acttattgtt ttttaataaa aaaaaaaaca ataaatgtag gaaaaattag gctagatgta
      601 ggaaaaatta ggctagcagt gggaaagatg taggaaaaat taggtcattc acaatcaaac
      661 acaaaaaatg tagttgattt aaatcgctac accattatga ttcatgtagc gatttaaatt
      721 actacataat ggtgattagc atgtctgaat tagttgtgtt taaagcaaat gaattagcag
      781 taagccgtta tgatctaact gaacatgaaa ccaagctaat tctgttttgc gttgcaaagt
      841 tgaaccctac aattgaaaac ccaacaaggg atgaattaac agttaaattc tcatgttctg
      901 aatatgcacg cactatgggc ttaagttatg aaaatgcttg gggaagattg aacagtgcaa
      961 ctagtgattt atttaaacgc tctgttgaat taatttatcc tacaggagca gtttctaaac
     1021 gaattttcaa ttggacggaa tacgctgagt tcaatagaga agaacaaact gtaacattag
     1081 tatttagctc atatattcaa ccacttttat ttcatttaaa aaaattcatt aaatacaacc
     1141 ttgagcatgt taaagccttt gaaaataaat actcaatgcg aatatatgaa tggttactaa
     1201 aggagctttc acaaagaaaa acgcataggg gaaacattga gataagtatc aaggaattta
     1261 agtttatgct catgcttgaa aaaaactacc ctttatatgc agaattgaat cgctggatcc
     1321 taaaaccagt tacaaatgac ttaaacactt acagcaatat gaagttgact attgaaaaac
     1381 gcggtcgtcc tgctgacaca ctgatctttc aagttgaact ggataaacaa attgaccttg
     1441 tgactgaact agcaaaagat cccgcatcaa aaaaagaaga taagacaatc cgtttaacgc
     1501 ctgaaaatcg tcttcatgag gggctaaaaa caacattgca tgatgcttta actgcaaaaa
     1561 ttcaactgac tagttttgaa gcaaaattcc tgagcgatat gcaaagcaag tacgatctta
     1621 acggctcatt tacatggctg actcaaaagc aacgaactac gctagagaaa attctggcta
     1681 aatacgggcg gatatgaggt atctatggca ctggtatcag ttacagaggc agccagacta
     1741 actggaaaaa acagagcaat aatacatcgc tatattaagc aaggaaaact gtcgcaaatt
     1801 tctgatgcaa caaatacaaa aaaagtagat acatcagagc ttattcgtgt atttggttca
     1861 ctaactgcga cacatgcaac actgtcgcaa agcgacgcaa tgcagcacga tgcaacacct
     1921 aaaacagatc aatccgttgc actgttacaa caaaaaattg cacttttaga acaactactt
     1981 gaaagcaaaa ataacgaatt gcaacgtcag gacgagcggt gatgctgcca acttactgat
     2041 ttagtgtatg atggtgtttt tgaggtgctc cagtggcttc tgtttctatc aactgtccct
     2101 cctgttcagc tactgacggg ggggtgcgta acggcaaaag cactgccgga catcagcgct
     2161 atctctgctc tcactgccgt aaaacatggc aactgcagtt cacttacacc gcttctcaac
     2221 ccggtacgca ccagaaaatc attgatatgg ccatgaatgg cgttggatgc cgggcaactg
     2281 cacgcattat gggcgttagc ctcaacacga ttttacgtca cttaaaaaac tcaggccgca
     2341 gtcggtaacc tcgcgcatac agccgggcag tgacgtcatc gtctgcgcgg aaatggacga
     2401 acagtgggga tacgtcgggg ctaaatcgcg ccagcgctgg ctgttttacg cgtatgacag
     2461 gctccggaag acggttgttg cgcacgtatt cggtgaacgc actatggcga cgctggggcg
     2521 tcttatgagc ctgctgtccc cctttgacgt ggtgatatgg atgacggatg gctggccgct
     2581 gtatgaatcc cgcctgaagg gaaagctgca cgtaatcagc aagcgatata cgcagcgaat
     2641 tgagcggcat aacctgaatc tgaggcagca cctggcacgg ctgggacgga agtcgctgtc
     2701 gttctcaaaa tcggtggagc tgcatgacaa agtcatcggg cattatctga acataaaaca
     2761 ctatcaataa gttagagtca ttaccaacac tgatataatg gcggtttaga acctatctca
     2821 atagggatta attaccgcat aaaaaatata ttatcactgt aaccaaaacc ttatacagcc
     2881 tgacttttaa acatcgatat ggctgggtaa ggtcatgaat ttagctccta ttgagatagg
     2941 ttcttagttc cgaatgaatc agagccgctt ttcgtttatt aatcaggaat ccctagtatt
     3001 tttaataact ttacattatt tacatttgca tcgaatcttt ctcttgctaa cttataactt
     3061 tcttctccca tactgattat tttttcagga ttattaatta acttcagcat tttttctgca
     3121 agatcttcat gtgaccattt ttttacaaca tatccattca caccatcaat aattgtttct
     3181 ttgcagcctg gtaaattagt agttaaaatc ggcctcccca tagccatcgc ttcttgtgta
     3241 ctacgaggaa ctccctctcg ataataggaa ggaagaacaa atacgcttga tttttcaatc
     3301 caatcagcca cattagaaac aaatccggga taagaaataa ctcctgattt aattaaagta
     3361 tctacgtcag attcagataa ccctccgggg ttttccttat ctatagcgcc aagtataata
     3421 aattcaacat tgggatgtgt tttttttatt ttttttgcgg cagcaacaaa ctcattgact
     3481 cctttttctg ctagcaaacg agctataaaa atgaatgata tttcatttgt tggtggcgtg
     3541 cttttacagt aattattcat atctaaacca atgccaccaa gaatatggca agattttaat
     3601 tttattttgt atttatctat caaatcatga taatcatcct tgttaaggag tattaatgag
     3661 ttgatatgtg gaaatattat tttatacagg agaacctgga tatttttaag taactttgtt
     3721 tttaacggag ttccatgtgg ctgctctgta aataaaaaac ctaacccctc aagcatagcg
     3781 ttattatttt taacgcctga aaaaatacca gccaacgatc caaagataga gggctttgaa
     3841 aaaaaagata aaatagcatc tggttttatc ttctttagtt ttttacttaa taagtaagta
     3901 ttccataaat caccagcaag gttaatacca ctgcgactta aattataatc aacaggaatg
     3961 gcgcctgctt tttttattat ttccttggat gaatcattat agtcagtagc aaaagcatag
     4021 actgaaatcc ctttcttggt tagtgttttt attaaatcca atctaaacaa aatcatagca
     4081 tttgctgtgt tccctattat tgagatcttc attatttatt acccttacct ttatttttct
     4141 ttgttaaagc gcatcttctt tcatatttta tcaaagaaaa caagatcgca ggcactgcca
     4201 ttattttacc tttcaacaag aagttaaata tattttttaa ctcccacttc tccatcaacc
     4261 ataaattacc actcaaccct gacactccaa agttaaattt atcgagaaaa accaaatccc
     4321 ttccatatat taatccacat ttgttttttt attataaacg ataacaagcc atgacatgta
     4381 gtcctctgaa aaacgctgat tctcattaaa tggaataaaa atatctcttt tcataatgac
     4441 agctggagtc tggaaataat tcttaaacaa catcatgtta aatgaaatta tttttaattt
     4501 taaatgttct tttttaattc cttggttaat ttcttggtta tttttctcac caatggaaca
     4561 cgttgaacct aaaaaatcca agttttcatc attaataaat gatagttgta attctagttt
     4621 ttttggatgc cagtaatcat ctgcatccaa aaatgacaaa aaatgccccg tagatagtga
     4681 aaccccttta atcctggaaa atgacggccc tgaattgtcc tcattattaa aagcaaaaac
     4741 atttccatac aatgagctta atttctttaa aatattccag ctattatctg acggtccatc
     4801 atttatacaa ataatctcta tatttctatg ggtttgtttt aatgcggaaa gaacgcatct
     4861 ttctatagtt tttccgttat taaaacaggg gatgataata ctaaccttat ggtttttcat
     4921 tgctcactct tcttacttat atttacaaag gtaaataata atataataac aaagtatagg
     4981 actctcactt gccagtagaa cagagaaatg aacatatagt atatagtcaa gaacataccc
     5041 ccaaaataac atttgatttt gcgggggttc ttgaaaccat taatatagca ccatcattac
     5101 aattgctaat atcaaaatac tagaatcaat aatagttgat aagtaaaaat tatgtggatc
     5161 ctgtgttaat gtactatagc caataccatt accaataaac attgtcttta gattacttat
     5221 ttcaacaata gcatttttaa atctggctat tctatcacta tcacttgctt tactaactat
     5281 tcgttctgtt atatttggtt ctgtgacaaa tgaagctcca ttattctcag tcactacagc
     5341 gggaatgttt ttcatcacta caaaagacat tgcaagtgaa atcataatta gtgccaacaa
     5401 ccttagctgt gttttcttta gcacaaagaa tgaataaaca cttacaataa gaaaggaaat
     5461 aaaaaaaaga taaaaaagaa ctccgtgata aggtcaaaaa tgaacacatc attgacaata
     5521 tgaatataat attaattgtg tatttatttg gtaatgtgaa aaacatatag attgagccaa
     5581 tgcataacat aaaagctaac acatttgggt cacttgaact ttcataaccc aaaggaaaat
     5641 aagaccatga gttatcataa aaaacaggaa ccgttaaacg cccccagtca ccaaagccaa
     5701 gttgaaataa tttaatcaac aaaaaagagc taacaaaaag caggcctaaa gcaattaaat
     5761 atgataaatg tattggtttt cttttaaaga agaaaataaa ccacatagat attactatat
     5821 atacagcatg actagtaatt agagtgatag atttatgatt atatacaaaa atgttaatga
     5881 caaggtaagc gactactaag cacaggagaa aaatatgtga tctttttata aaagactttc
     5941 tttttataag ccaatagcaa cctaatagtg tacaggaaaa gagagcgtat actgtaacca
     6001 catgatcact attgactccc atgaccacct gtttattccc tcccataact gaccacaata
     6061 taaaaggaaa agtgcaaatg tatagataaa aacacatagt gattcaactg gttattttta
     6121 ttgtagataa gattcttcta taatatcata aacatgatac cgcactcaac atttttaaca
     6181 gatgatattg tttatgaaca gacttttttc taatgctttc tggttaatgg catctcagat
     6241 tggcggcctt cgaatctcct tgatcgaact gccattgctt gccagaagac tgggggctga
     6301 tgaatatgga aaagttgtat atgttttagc tatttccata atggcttctg ttttcattta
     6361 gtatggattc aatttcagtg ctgtgaaaaa aatcgtagga aggaaatatg gtaaatatat
     6421 ttcacaaatt tcaacagatg tttttcttgc taagataact cttagtatta tacctattat
     6481 tttagctctc cccctaatat acacaacatc tagcggaata tctataccta ataattggtt
     6541 tgtatggctt attttattta tcttatcttt tggattcact ccgttctggt attacatatc
     6601 aatagaaaat ataattcccc ccgcaatact cgatctttta ctaagagtga caggtttaat
     6661 tctcattgtt atttttgtta actccccgag tgacgcaaaa accacaatag ccattcaatc
     6721 aatggtagga gcgttaaata cattaatatc aactgctgtt gttttttatt tgtcgggagt
     6781 aggagcgatt aatattaaaa gagcgcttaa tgaaattaaa gatgggttta gtgtattttt
     6841 gtataaaagt tcacaaggaa taatgataac catgtcatca tcattattag tttttttggg
     6901 gggctaaatc tgttgttttt tttgttccat ctgaaaaagt aactaaggtt ataacaacat
     6961 taatgataac aatgctaaac gtagcatatc cgcatttcgt taaaaatctt agtgatagca
     7021 aaaacggtga tgcctctaat tagttgaatc tgatgtataa tgcgggcttt tgaggttctt
     7081 tcatggccag cgttaacatt cattgtcctc gttgtcagtc tgcacaggtc taccgccatg
     7141 gtcagaacca cggcagcctg gcggctgcaa atcggggtgt ggcagaatat gagctttcag
     7201 agtaaccatc cagaatgagt tcccatgtca cacaacctgg agcaccagaa agtccacacc
     7261 agaatggtga aagaggttct gaaagccgtc gccagagcca ataatcaccc ttatcagtcc
     7321 gtatttacag actttatcgc cggtcatccc tcctgcacgg tctgtttctg ggaaaccttc
     7381 cacaaaatgt ccccggattc accgtacgaa tacgtcacgt tctgccatac ctgccgtcgt
     7441 tttgatttat acgaaacaga agcggagatg aaggcggatg acccgaagtg gtggtgattt
     7501 tcagccccga ccgctgaaac gcctgttcac aaccaaccag tgctggacat ccttcctgga
     7561 tgcgagcggt ctgcgcgata tcgaggttga ggctgtcaca aaaatgctgg cctgcggcac
     7621 gcggatactg ggcgtgaagg aatacaactg cgataaacct gagtgccccc acgtcagata
     7681 cgtcactaac tcatgcggca gccgtgcctg cccgtcctgc ggaaaaaagg ccacagacct
     7741 gtggatagcg acacagctga atcgtcttcc tgactgcgac tgggtacatc tggtcttcac
     7801 cctgccggac acgctgtggc cggtgttcga aagcaaccgc tggctgctga atgacgtgtg
     7861 ccgtctggcg gtggagaatc tgctgtatgc cgcccggaaa cgggggcagg aacccggtat
     7921 cttctgcgcc atccacacgt atggccgtcg tctcaactgt catccgcatg tacatgtgtc
     7981 tgtaacctgt ggatgtctga ataagcatgg tcagtggaaa aagctgagct tcctgaaaga
     8041 cgcgatgcgt tcgcggtgga tgtggaatat gcggcagctg cttctgaaag cgtggtcaga
     8101 ggggctggcg atgccggagt cgttgtcaca tatcacgacg gaatcacagt ggagaagcct
     8161 ggtgctgaaa gccggcggaa aatactggca tgtgtacatg tcgaagaaga cagccggcgg
     8221 gaggaatacg gcgcgctacc tgggtcgtta tctgaagaag ccgccgatag cggcctcccg
     8281 gctggcacat tacaacggag gggcgagcct gagcttccgt tacctggacc acaaaacggg
     8341 agaaacggcg atggaaacgc tgacacagcg tgagctggtc gcgaggctga aacagcacat
     8401 cccggagaag ttttttaaga tggtgaggta cttcgggttc cttgccaacc gtgtgtgtgg
     8461 agagaagctg ccgcaggtgt accgtgctct ggggatggat aaaccggcac cggtggcgaa
     8521 ggtgtgctat gcacaaatgg tgaagcagtt cctgagtcgt gacccgttcg aatgcgtgct
     8581 gtgtggcggc cggatggtat accgccgggc catcgcggga ctgaatgtgg aggggctgaa
     8641 gaaaaacgcg cgggatatca gtctgctgag gtatatgccg gcctgacaca ggctaagtgt
     8701 gcccgggaat cggtgcaagt ataaaaaata gcctgttact gcataaaaac tgaccatgca
     8761 gagagagaaa acaccggagt ggagggaaaa gcagaaaatc tcacgtggca taaggcgcgg
     8821 acaggggtat cgcttagttt ttcaatttcc tatacgtcaa gcagagaagc gtgcagaagc
     8881 caaagctgcc cgtaaagcac gtgaccatgc cctttatcaa tcagcggggt tactcatcat
     8941 ggcggggtta gtg
//
