LOCUS       NC_007171               8180 bp    DNA     circular CON 17-FEB-2024
DEFINITION  Staphylococcus haemolyticus JCSC1435 plasmid pSHaeC, complete
            sequence.
ACCESSION   NC_007171
VERSION     NC_007171.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMD00061066
            Assembly: GCF_000009865.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus haemolyticus JCSC1435
  ORGANISM  Staphylococcus haemolyticus JCSC1435
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1
  AUTHORS   Takeuchi,F., Watanabe,S., Baba,T., Yuzawa,H., Ito,T., Morimoto,Y.,
            Kuroda,M., Cui,L., Takahashi,M., Ankai,A., Baba,S., Fukui,S.,
            Lee,J.C. and Hiramatsu,K.
  TITLE     Whole-genome sequencing of staphylococcus haemolyticus uncovers the
            extreme plasticity of its genome and the evolution of
            human-colonizing staphylococcal species
  JOURNAL   J Bacteriol 187 (21), 7292-7308 (2005)
   PUBMED   16237012
REFERENCE   2  (bases 1 to 8180)
  AUTHORS   Takahashi,M., Fukui,S., Baba,S., Ankai,A., Terui,Y., Fukuhara,Y.,
            Oguchi,A., Hongo,Y., Yanagi-i,M., Watanabe,S., Takeuchi,F.,
            Kuroda,M., Ito,T., Cui,L., Ma,X., Morimoto,Y., Yuzawa,H., Baba,T.,
            Hiramatsu,K. and Isono,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-DEC-2003) Contact:Mikio Takahashi National Institute
            of Technology and Evaluation, Bio Technology Division Tohoku Branch;
            4-5-18 Higashisendai Miyagino-ku, Sendai, Miyagi 983-0833, Japan URL
            :http://www.bio.nite.go.jp
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/17/2024 01:41:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,663
            CDSs (total)                      :: 2,581
            Genes (coding)                    :: 2,501
            CDSs (with protein)               :: 2,501
            Genes (RNA)                       :: 82
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 62
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 80
            CDSs (without protein)            :: 80
            Pseudo Genes (ambiguous residues) :: 0 of 80
            Pseudo Genes (frameshifted)       :: 38 of 80
            Pseudo Genes (incomplete)         :: 39 of 80
            Pseudo Genes (internal stop)      :: 17 of 80
            Pseudo Genes (multiple problems)  :: 13 of 80
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP006719.1.
            Takeuchi,F., Watanabe,S., Baba,T., Yuzawa,H., Ito,T., Morimoto,Y.,
            Kuroda,M., Cui,L., and Hiramatsu,K. are at the Department of
            Microbiology and Infection Control Science, Juntendo University,
            Tokyo 1138421, Japan.
            Takahashi,M., Ankai,A., Baba,S. and Fukui,S. are at the National
            Institute of Technology and Evaluation, Miyagi 9830833, Japan.
            Lee,J.C. is at the Department of Medicine, Brigham and Women's
            Hospital and Harvard Medical School, Boston, Massachusetts 02115,
            USA.
            Present address of Yuzawa,H.: Laboratory of Social Genome Science,
            Department of Medical Genome Science, Graduate School of Frontier
            Science, University of Tokyo, Tokyo 1088639, Japan.
            Present address of Kuroda,M.: Department of Microbiology,
            University of Tsukuba, Ibaraki 3058575, Japan.
            Please visit our web site
            URL:http://www.bio.nite.go.jp/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..8180
                     /organism="Staphylococcus haemolyticus JCSC1435"
                     /mol_type="genomic DNA"
                     /strain="JCSC1435"
                     /db_xref="taxon:279808"
                     /plasmid="pSHaeC"
     gene            542..1408
                     /locus_tag="SH_RS12975"
                     /old_locus_tag="pSHaeC01"
     CDS             542..1408
                     /locus_tag="SH_RS12975"
                     /old_locus_tag="pSHaeC01"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829553.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RepB family plasmid replication initiator
                     protein"
                     /protein_id="WP_011276922.1"
                     /translation="MSGETVVYRNEMNLVPLRRFTSTEVDLFFTLCNKLKEQDTRKVTI
                     PFAELKYLSNYYTRSQERFINDLEHVYDKMLNLTYIERNGRSFEKFILFTSYKVDLDEE
                     CLSISINSDLKHILNSITADFTKFELKEMTHLKSTYAKNMFRILKQYKHTGYVKMNLDD
                     FKNRLDVPKTYQMNDITKRVLKPIINELSQIFNNLHINKIKAKKGRKIEWLEFTFDAEK
                     RIHSKRQPKMANVAQPKQYISREKTPKWLHERNQSNTTREMTEEEKELLKEQQQAFRQQ
                     LELDWED"
                     /name="RepB family plasmid replication initiator protein"
     gene            complement(1986..3158)
                     /locus_tag="SH_RS12980"
                     /old_locus_tag="pSHaeC04"
     CDS             complement(1986..3158)
                     /locus_tag="SH_RS12980"
                     /old_locus_tag="pSHaeC04"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002492371.1"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="WP_011276924.1"
                     /translation="MIEVKSNIRLYVLGFLAFFASLIQNIYTPIIPRLHEDFHVSLFWI
                     NVTVGGFIFIVAIMQIVLGKSIDSRDSKKVLLTGLGIVIISSLMCAITNNFVLFATARL
                     FQAIGCGIIPLVTLTLLAKLSEGDSRASAMANYQIFLSCAPAIAPILGSSIGAKWDYIG
                     IFSFLFIISILLFLIITFTKIPNVEKGVGKLTEKVNEKYLSDKVFITLVVLGFLAFFTY
                     FSILVYLPTLLNHVYNISEGISGILFLPITVSVILGSMFYKKIAKKYNSLMILRCTIII
                     FSIFTLLFGIFNSVNLIILSFIIFVLGFFVGVVPALLSTLISQRFENIKGKVLGIFNFV
                     RYIGMTIGAILIGLVSQLFIPYYFGIVSIILIIILIYIKAKTFENMFNKE"
                     /name="MFS transporter"
     gene            complement(3151..3612)
                     /locus_tag="SH_RS12985"
                     /old_locus_tag="pSHaeC05"
     CDS             complement(3151..3612)
                     /locus_tag="SH_RS12985"
                     /old_locus_tag="pSHaeC05"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016187295.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_145424740.1"
                     /translation="MQKKVILMLQQFIIERENADKRRQYRKGNEDMDLSLTQFHIIEII
                     DKHEKVNNKFLAEELNVSKPAVTKSIKKLLSKELVVELNNESNKREVYYNLTKRGEKLS
                     FIHDDLHKKAVKKYEEVLKVFDEKEMETIIEFLKRSVDELKKEEVDSND"
                     /name="MarR family transcriptional regulator"
     gene            3775..4479
                     /locus_tag="SH_RS12990"
                     /old_locus_tag="pSHaeC06"
     CDS             3775..4479
                     /locus_tag="SH_RS12990"
                     /old_locus_tag="pSHaeC06"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002492512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_011276926.1"
                     /translation="MQNFKVDFLTKNCKQIYQRKKHVILGISPFTSKYNESYIRKIIQW
                     ANSNFDDFSILLAGEESKNLLECLGYSSSKANQKVRKEIKRQIRFCEDEIIKCNKTITN
                     RIHRFSDFKNNIYYIDIYKTIVDQFNTDSNFKNSCLKMSLQALQSKGKNVNTSIEITDE
                     TLEYAAQYVLAELPFFLNANPIINTQETLMAYHAPWELGTNIINDQFNLKMNEKQGYII
                     LTEKGDNYVKSV"
                     /name="tRNA-dependent cyclodipeptide synthase"
     gene            4463..5662
                     /locus_tag="SH_RS12995"
                     /old_locus_tag="pSHaeC07"
     CDS             4463..5662
                     /locus_tag="SH_RS12995"
                     /old_locus_tag="pSHaeC07"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002492554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytochrome P450, cyclodipeptide
                     synthase-associated"
                     /protein_id="WP_011276927.1"
                     /translation="MLKVSKSIFDKEYEINPISYFQFFRENDPVHYEKSVDAYFISNYT
                     DVKYVLKNNDTFTTKTLAERAEPVMKDRVLAQMSGHEHKSKKKAILKGMTGKYLEKLMP
                     ILETRTNNIIDQFIDKKEIDIVNDFGKVFAVQSSMDLLGINVEDSEKIREWHNGIAKFI
                     TSFNLSDEEIKYSMHCSDKLEEYLMPLIEERKYSNKDDLISLLHEYKDAENEITDTEIL
                     ALTLNILLAATEPVDKTLAYLFYNLLNSPNQYQDVIDNPKLLRSAITETLRFNSPVQLI
                     PRQLSEPCTLHNKNLKAGDTVICMIGAANRDPKAYTNPDIFNIHRKSESNKPFTSHSQN
                     LSFGSGVHTCVGASFSLIQLEMVTKILLKRLKNIKLKTMNLEEKGLYTRGPKSMVISFD
                     "
                     /name="cytochrome P450, cyclodipeptide synthase-associated"
     gene            5908..6291
                     /locus_tag="SH_RS13000"
                     /old_locus_tag="pSHaeC08"
     CDS             5908..6291
                     /locus_tag="SH_RS13000"
                     /old_locus_tag="pSHaeC08"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011251337.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid mobilization relaxosome protein MobC"
                     /protein_id="WP_011276928.1"
                     /translation="MSEQNKFVASDETVGKNHKPNRKEPKQISFRVSESEYLKLKQSAE
                     TLNMSVPAFVKKKAQGSRLVAPKFDKETRQSIAKDLSMLGSNANQIAKYCNQHQHEAPN
                     YEALEYNIHELRERLDDIWQRLK"
                     /name="plasmid mobilization relaxosome protein MobC"
     gene            6460..7467
                     /locus_tag="SH_RS13010"
                     /old_locus_tag="pSHaeC10"
     CDS             6460..7467
                     /locus_tag="SH_RS13010"
                     /old_locus_tag="pSHaeC10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="WP_011276930.1"
                     /translation="MATTKLSATKSTSRAINYAEKRAEEKSGLNCDIDYAKSSFKATRE
                     LYGKTGGNEGHVIIQSFKPGEVTPEQCNQLGLALAEKFATNHQVAVYTHCDTDHIHNHI
                     VINAVNLETGKKFNNNKQALRDLRDFNDNVCREHGLSVPEKDTARLRYTQTEKAIADPN
                     TKSTAQYSWKDEIREAIDQSKATNMDEFKEHLSQYGIEIARVTPKSITYRHLAEDKKVR
                     GRRLGEDYNKGGIEDGFERQIQRQQQEREYDKDIQPKRPTSNRDEPAQRDTGVTQSDWD
                     KFAQDTNELERRRQAAESARLVDEKARRDREERERAEQASRTIIDNDRDHGLEL"
                     /name="relaxase/mobilization nuclease domain-containing
                     protein"
     gene            7457..7975
                     /locus_tag="SH_RS13015"
     CDS             7457..7975
                     /locus_tag="SH_RS13015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002475811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mobilization protein"
                     /protein_id="WP_232502630.1"
                     /translation="MNFNQATEKNQKRFISVAKHYVERINNDNLKQDFQSAIQQELEDV
                     KSQTQNLVKQFQNHQSDLQKAHDDYKKTLDERIETNEIAIKQYDQAFNRLTKGITAMFF
                     IVALVMITFVVLSPLGDLLGVQHFYDWINHVLKTGHSAWRYLIVTLYLAPYILFSLLIY
                     AILKAYERL"
                     /name="mobilization protein"
     BGC             1..8180
                     /name="CDPS"
                     /gene="CDPS"
                     /tool="antismash"
     Typing          complement(5701..5937)
                     /name="MOBP"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="3.49e-121"
     Typing          543..1408
                     /name="rep_cluster_1442"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          6452..7464
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="96.154"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 tgtgcattga gaagaaccct taattaaact gtttcgacga atgtcggtat agcgtgagct
       61 ataaaaccga cgagtcgaca gtttaagggt ttattaaggg ttcagaggct caatgtcaat
      121 aaagcaattg gaataatgca ataagtaaat gatttttatt aatcaaaacc aaccataaaa
      181 aatggttggt ttcctttttg ttttttgggg aattttgagg ggcaattgcc ccgaactttt
      241 taatatcttt ttataaatct ttttaaaacc tttttaggca tctgttgagc cttagagcga
      301 caatggattt ggaatgctaa aagggacatt ttgtaacagt aaaagggaca ttttgtaaca
      361 gtaaaaggga cattttgtaa cagtaaaagg gacattttgt aacagtaaaa gggacatttt
      421 gtaaatcatg tcacttataa ttcttttttc tctatataat aagtgttata atactttcaa
      481 atattatttt aaagggacat tttgcaaatc atgtcactta taatatcgag aggagttttg
      541 tatgtctggt gaaacagtag tatatagaaa tgagatgaat ttagttccat taagacgttt
      601 tacaagcact gaagtagatt tattctttac tctatgtaat aaacttaaag agcaagacac
      661 aagaaaagta actattcctt ttgcagaatt aaaatattta agtaattact atactcgttc
      721 acaagaacgt tttattaatg atttagaaca tgtatacgat aaaatgctta acttaactta
      781 tatagaacgt aatggtagat catttgaaaa atttattttg ttcacttcct ataaagtaga
      841 tttagatgaa gaatgtttat ctattagtat taattctgat ttaaaacata ttttaaattc
      901 tataactgcc gattttacaa aatttgagtt gaaggaaatg acacatctca aatccaccta
      961 tgctaaaaat atgtttagga tacttaaaca atacaaacat actggttatg taaaaatgaa
     1021 tttagatgat tttaaaaatc gtctagatgt cccaaaaact taccaaatga atgatataac
     1081 taaacgggta ttaaaaccaa taattaatga actatctcag attttcaata atctacatat
     1141 caataaaatt aaagcgaaaa aaggacgtaa aatagaatgg ttagagttta cttttgatgc
     1201 tgagaaacgc attcatagta agcgacaacc caaaatggcg aatgtagccc aacccaaaca
     1261 atatatcagt cgtgagaaaa cgccaaaatg gctacatgaa cgaaatcaaa gtaatacaac
     1321 tagagaaatg acagaagaag aaaaagaact attaaaagaa caacaacaag catttagaca
     1381 acaattagaa ctagattggg aagattagaa agtttacaaa agatagcatg aaagatatac
     1441 tgaagttaac aaacagacag atacatcatt agatgtgaaa accccagcat gccgaccaaa
     1501 gcatatgctg gggtttcttt tttatcgttt atgttcttga tttaataaat aaagaacacg
     1561 cccaacaata attggacata cgatatactt cataacaaac agaacgacaa tcattagatg
     1621 tggcacctcc tttctgcaca ggaagtgcct tacaagtata atataataac gtgatatttg
     1681 acgaatacat gagccttcaa aaaagtattc aaagtgtgca aagtatacat tcgatacttt
     1741 gcacactttg aatactttgt atacacatgt aacttacata aaaatacaaa atatggatca
     1801 atgaaaatga ctgaaaacgc atcagatcaa tgatgtataa aacctgcata aacgataatg
     1861 ataagtaaaa ggcttaaacg ctgttaaatc aacgtttaag ccttttgctt tagttaacat
     1921 aattaattct tatgggtagt tgaaatgtat agcttattca tatttactgc tattcaatat
     1981 agaattcact ctttattaaa catattttca aatgtttttg ctttgatata gataagtatt
     2041 attattagaa ttatagaaac tattccaaaa taatatggta taaataattg agatactaat
     2101 ccaatcaata ttgctcctat tgtcatacct atatacctta caaaattaaa aattcctaaa
     2161 accttaccct ttatattttc aaatctttga gatattaacg tcgatagcaa cgcaggaaca
     2221 acaccaacaa aaaaacctag cacaaaaata ataaaagata agattattaa atttacagag
     2281 ttaaatattc caaataataa ggtgaatata gaaaagataa ttatagtaca tctaagtatc
     2341 attaagctgt tatatttttt ggctattttt ttatagaaca tactacctaa tatgacacta
     2401 acagtaatcg gtaaaaataa tataccagat atgccttcac ttatattata tacatgattt
     2461 agtaatgtag gtagataaac taatatagaa aaataagtaa aaaatgctaa aaatcctaat
     2521 accactaaag taataaaaac tttatctgat aagtattttt cattcacctt ttctgttaat
     2581 ttccctacac ctttttcaac atttggaatc ttagtaaaag taataataag aaataataag
     2641 atggatataa taaataaaaa actaaagata cctatataat cccatttggc acctatacta
     2701 ctacccaaaa tgggcgctat tgctggtgca cacgataaaa atatctggta atttgccatc
     2761 gcagatgctc tgctatcacc ttcacttaat ttagccaata gagttaaagt tacaagtgga
     2821 atgattccac aaccaatagc ttgaaataat ctagccgtcg caaacaaaac aaaattattc
     2881 gttatagcac acattaagct agatatgata acaattccta agcctgttaa aagtactttt
     2941 tttgaatctc tagaatctat actttttcct aaaactatct gcattatagc aactataaat
     3001 ataaaaccgc ctacagttac atttatccaa aataacgata catgaaagtc ttcatgtaat
     3061 cttggaatga taggtgtata tatattttga attaatgaag caaaaaatgc taaaaatcct
     3121 aaaacatata atcttatgtt acttttcacc tcaatcattt gaatcaactt cttctttttt
     3181 taactcatca acgcttcttt ttagaaattc aatgatagtt tccatttctt tttcatcaaa
     3241 tactttcaat acttcttcat atttttttac tgctttttta tgtaaatcat catgtataaa
     3301 agaaagtttt tctcctcttt tagttaaatt ataataaact tctcttttat ttgactcatt
     3361 attcagttca actactaatt ctttagataa aagtttctta atagattttg tgactgctgg
     3421 cttggatacg tttagttctt cggcaagaaa cttgttatta actttttcat gtttatcaat
     3481 gatctctatg atatgaaatt gagttaaaga taaatccata tcctcatttc cttttctata
     3541 ttgtcttctt ttatcggcat tttctctttc tataatgaat tgttgtaaca ttaatatgac
     3601 ttttttttgc atattcatct tttctctctc ctttgttgtt aaccggttaa caatattatt
     3661 acttatctcc ctttttttgt caaatgcaat tgcttacact atataattct gatattctat
     3721 aaattgttaa ccaggtaaat attaataggt taacaatagg cagggaggga taacgtgcaa
     3781 aactttaaag tagacttttt aacaaaaaac tgtaaacaaa tctatcaaag aaaaaaacat
     3841 gtcattttag gaattagccc ttttacaagt aagtataacg aatcctacat aagaaagatt
     3901 attcaatggg ctaattcaaa ttttgatgat ttctctattt tattggcagg agaagaatct
     3961 aaaaatcttt tagaatgctt aggatattca tcttctaaag ctaatcaaaa agtacgaaaa
     4021 gaaattaaac ggcaaatcag attttgtgaa gatgaaatta taaagtgtaa taaaaccata
     4081 actaatagaa ttcataggtt ttctgatttt aaaaataata tttattatat tgatatatat
     4141 aagactattg tagatcagtt caatacagat tctaatttta aaaacagttg tttaaaaatg
     4201 tcacttcaag cattacaaag caaaggaaaa aatgttaata catccataga aatcactgat
     4261 gaaactttag agtatgcagc acaatatgtt ttagcagaat taccattctt tttaaatgct
     4321 aatcccataa ttaatacaca agaaacttta atggcttatc atgctccatg ggaattaggt
     4381 actaatatta taaatgatca gttcaattta aaaatgaatg aaaaacaggg ctatattata
     4441 ttaacggaaa aaggggataa ttatgttaaa agtgtctaaa agtatttttg ataaagagta
     4501 tgaaataaat cctatttcgt atttccaatt ttttagagaa aacgacccag ttcattatga
     4561 gaaatcagtt gatgcttatt ttataagtaa ttatacagat gttaaatatg ttcttaaaaa
     4621 caacgatact ttcactacta aaacattagc cgaaagagct gaacctgtta tgaaagatag
     4681 agtattagca caaatgtcag gtcatgaaca caaatctaaa aagaaagcta ttttaaaagg
     4741 tatgactgga aaatatcttg aaaaattaat gcctatatta gaaacacgaa caaataatat
     4801 tatcgatcaa tttatagata aaaaagaaat agatatagta aatgactttg gaaaagtatt
     4861 tgcagttcaa agttctatgg acttactagg gataaatgta gaagactctg aaaaaattag
     4921 ggaatggcat aatggtatag ctaaatttat aacatctttc aatttaagtg atgaagaaat
     4981 taaatactca atgcattgta gtgataaatt agaagaatat ttaatgcctt tgattgaaga
     5041 gagaaaatat tctaataaag acgacttaat ttctctttta catgaatata aagatgctga
     5101 aaatgaaatt acggatactg aaattttagc tttaacttta aatattttat tagctgcaac
     5161 agaacctgtt gataaaacat tagcttattt attttacaat ctattaaata gtcccaacca
     5221 atatcaagat gttatagata accctaaatt attgagatca gcaatcacag aaacacttcg
     5281 tttcaattca ccagtacaat taatacctag acaattatct gaaccatgta ctttacacaa
     5341 taaaaattta aaagcaggtg acacagttat atgtatgatt ggtgctgcta acagagaccc
     5401 aaaagcttat actaatccgg atatatttaa tattcacaga aaatctgaaa gtaacaagcc
     5461 atttacttcg cattctcaga atttatcatt tggatcagga gttcatacat gtgtcggtgc
     5521 atcattctca ttaatacaat tagaaatggt taccaagatt ttattaaaaa gattaaaaaa
     5581 cattaaatta aaaacaatga atcttgaaga aaaaggacta tatactagag gaccaaaatc
     5641 tatggtaatt agttttgatt aattcatttt tgtatctatt attgaatatt ttgaatttaa
     5701 gtggctaaca attagccact attttttcgt cagaaaaaat cctaaggggc ttggggatta
     5761 tccccaacaa gcaggcgtcg ctaccacgtg agtggctagc aaagccaatg cttgccaaac
     5821 cactttatta cttgatgaaa tttagattat catataatct aaatttatat taagtaatat
     5881 ctttcgaaga aagcgtggtg ggatttgatg agcgaacaaa ataaatttgt ggctagcgat
     5941 gaaactgttg ggaaaaacca taaacccaac cgtaaggagc cgaaacaaat tagttttcgt
     6001 gtgagcgaat ccgaatattt aaagttaaag cagtcggctg aaactttaaa tatgagtgtg
     6061 cctgctttcg ttaagaaaaa ggcacaaggc agtcgattgg tcgcacctaa atttgataaa
     6121 gaaacgcgac aatcgattgc caaagattta agtatgttgg gttcaaacgc aaaccaaata
     6181 gctaaatatt gcaaccaaca tcaacatgaa gcaccgaatt atgaagcatt agaatataat
     6241 atccatgaat tacgagaaag gttggatgac atatggcaaa ggctaaaata agaataattt
     6301 ctttttttct cttattcata tttgtaatta cttatgctgt tctttctttc acaacagatt
     6361 atattaatca caagtattct cttttatttg tattagtttt cgcattatgg ggcattttaa
     6421 ctgatatttt aactaaaccg aataaacgag atgataatag tggcaacaac taaattaagt
     6481 gcgacgaaat caacgtcacg tgccatcaat tacgctgaaa aacgggctga agaaaaaagc
     6541 ggcttaaact gcgacataga ctatgccaaa agtagtttta aagccacacg tgaactttat
     6601 ggtaaaacag ggggcaatga aggccatgtc attattcaat catttaaacc aggcgaagta
     6661 accccagaac aatgtaatca attaggctta gcattagctg aaaaattcgc aaccaatcat
     6721 caagtggctg tttatacaca ttgtgatact gatcacatac ataatcatat tgtgattaat
     6781 gccgttaatc ttgaaacagg taaaaagttc aataacaaca agcaagcctt acgtgattta
     6841 agggacttta atgacaacgt atgtcgcgaa catggcttaa gcgtgccaga aaaagataca
     6901 gcacgcttac gttatacaca aacagaaaaa gcgattgctg atcctaatac aaaatcaacc
     6961 gcccaatatt catggaaaga tgaaatacgt gaagcaatcg accaatcaaa agccacaaat
     7021 atggacgaat ttaaagagca tttaagtcaa tatggcattg aaattgcacg agttacacct
     7081 aagagcatta cctatcgaca tctagctgaa gataaaaaag tccgtggccg tcgattaggt
     7141 gaagattata acaaaggggg catagaagat ggctttgaaa gacaaataca acgacaacag
     7201 caagaacgag aatatgacaa agacatccag ccaaaacgac caacttcaaa ccgtgatgaa
     7261 ccagctcaac gagatacagg cgtcactcaa tcagactggg ataaattcgc ccaagacaca
     7321 aatgagcttg agcgtcgccg acaagctgca gagtcagcaa gacttgttga tgaaaaggct
     7381 cgaagagatc gagaagagag agaacgagcg gaacaagcgt cacgaacaat tattgacaac
     7441 gatagagacc acggccttga actttaatca agccacagaa aaaaatcaaa aaagatttat
     7501 tagcgttgcc aaacactatg tggagcgtat taataacgat aatttaaaac aagattttca
     7561 atcagcaatc caacaagaat tagaagatgt gaaatcacaa acacaaaatt tagttaaaca
     7621 gtttcaaaat catcaatcag acttacaaaa agcacatgat gattataaaa aaacgcttga
     7681 tgagcgtatc gaaacaaacg aaatagcaat aaaacaatat gatcaagcct tcaatcgttt
     7741 aactaaaggg attacagcca tgttttttat tgtcgcctta gtaatgatta cttttgtagt
     7801 cttaagtcca ttaggcgacc tattaggcgt acaacatttt tatgattgga ttaaccacgt
     7861 cttaaaaaca ggtcattcag catggcgtta tctaattgtg acgctttatc ttgcccctta
     7921 catattattt agtttgctta tatatgccat tttaaaggcg tatgagcgac tttaacctta
     7981 gtcagtatta aaaacctata acttatcatg aaaaacgctg catacggttt aaattagttt
     8041 agaaatggaa ttaaacattt tttataagga gatccgaaat gcttatattt ttgtttattt
     8101 taatgagtgg acttttaagt tattacttga ttaatcgttc aaacaaaaag aaatgacgct
     8161 attatgccga gaaaatttat
//
