LOCUS       NC_005207              30201 bp    DNA     circular CON 23-JUN-2024
DEFINITION  Staphylococcus warneri plasmid pPI-1, complete sequence.
ACCESSION   NC_005207
VERSION     NC_005207.3
DBLINK      BioProject: PRJNA224116
KEYWORDS    RefSeq.
SOURCE      Staphylococcus warneri
  ORGANISM  Staphylococcus warneri
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1
  AUTHORS   Aso,Y., Koga,H., Sashihara,T., Nagao,J., Kanemasa,Y., Nakayama,J.
            and Sonomoto,K.
  TITLE     Description of complete DNA sequence of two plasmids from the
            nukacin ISK-1 producer, Staphylococcus warneri ISK-1
  JOURNAL   Plasmid 53 (2), 164-178 (2005)
   PUBMED   15737403
REFERENCE   2
  AUTHORS   Aso,Y., Sashihara,T., Nagao,J., Kanemasa,Y., Koga,H., Hashimoto,T.,
            Higuchi,T., Adachi,A., Nomiyama,H., Ishizaki,A., Nakayama,J. and
            Sonomoto,K.
  TITLE     Characterization of a gene cluster of Staphylococcus warneri ISK-1
            encoding the biosynthesis of and immunity to the lantibiotic,
            nukacin ISK-1
  JOURNAL   Biosci Biotechnol Biochem 68 (8), 1663-1671 (2004)
   PUBMED   15322349
REFERENCE   3
  AUTHORS   Sashihara,T., Kimura,H., Higuchi,T., Adachi,A., Matsusaki,H.,
            Sonomoto,K. and Ishizaki,A.
  TITLE     A novel lantibiotic, nukacin ISK-1, of Staphylococcus warneri ISK-1:
            cloning of the structural gene and identification of the structure
  JOURNAL   Biosci Biotechnol Biochem 64 (11), 2420-2428 (2000)
   PUBMED   11193411
REFERENCE   4  (bases 1 to 30201)
  AUTHORS   Aso,Y., Koga,H., Sonomoto,K. and Nishie,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-OCT-2003) Contact:Yuji Aso Department of Environmental
            Science for Human Life, Faculty of Education, Shimane University;
            1060 Nishikawatsu, Matsue, Shimane 690-8504, Japan
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009940235.2-RS_2024_06_23
            Annotation Date                   :: 06/23/2024 08:27:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 32
            CDSs (total)                      :: 32
            Genes (coding)                    :: 31
            CDSs (with protein)               :: 31
            Genes (RNA)                       :: 0
            tRNAs                             :: 0
            ncRNAs                            :: 0
            Pseudo Genes (total)              :: 1
            CDSs (without protein)            :: 1
            Pseudo Genes (ambiguous residues) :: 0 of 1
            Pseudo Genes (frameshifted)       :: 0 of 1
            Pseudo Genes (incomplete)         :: 1 of 1
            Pseudo Genes (internal stop)      :: 0 of 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AB125341.3.
            On Mar 14, 2012 this sequence version replaced NC_005207.2.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..30201
                     /organism="Staphylococcus warneri"
                     /mol_type="genomic DNA"
                     /strain="ISK-1"
                     /db_xref="taxon:1292"
                     /plasmid="pPI-1"
     gene            196..807
                     /locus_tag="HXC01_RS00005"
                     /old_locus_tag="PPI1_p01"
     CDS             196..807
                     /locus_tag="HXC01_RS00005"
                     /old_locus_tag="PPI1_p01"
                     /function="unknown"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001076470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_011152929.1"
                     /translation="MNQSKIAKLRKDKSLTQENLAEKACVTVRTIQRIEAGEEVSSETL
                     KNISNVLDVTINELFESIASSDKEEEIMEIAKEQQKQFHYRRNEQLTFRFIAFGVIFVF
                     LGLFGIFVVGLNGLKQDIYGVVWIFMLFLSLAMMHYVLNVLISKKLDEKYPMTVGMNHK
                     RSNIKQEPIKNGWEFMARYWWIIFPIGGFLSWLIPELTGK"
                     /name="helix-turn-helix domain-containing protein"
     gene            complement(1134..1388)
                     /locus_tag="HXC01_RS00010"
                     /old_locus_tag="PPI1_p02"
     CDS             complement(1134..1388)
                     /locus_tag="HXC01_RS00010"
                     /old_locus_tag="PPI1_p02"
                     /function="unknown"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002477785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_011152930.1"
                     /translation="MYHHIQMYLEQLGYDIVEVILLFEKVEQNHADMDELNTLNRLASA
                     VYIHCQRHNLLVYTHPPTPFDPYELIEWFVFQSYDRDIT"
                     /name="hypothetical protein"
     gene            complement(1502..2368)
                     /locus_tag="HXC01_RS00015"
                     /old_locus_tag="PPI1_p03"
     CDS             complement(1502..2368)
                     /locus_tag="HXC01_RS00015"
                     /old_locus_tag="PPI1_p03"
                     /function="unknown"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002487364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_011152931.1"
                     /translation="MKKSIISMISLAFLLVGCGHHNQAANQTHVKLGDVMHQDQHISYL
                     VKKEDNPTPTKNSVVTAYIVTQNGKQTVYSSDQASDRTLGDFKDKSNKAIIDMAKKDDR
                     AAFQYEKKEMKQEIQKLVNRKQLEDHDDFKLKASDFQIQPETAIKHLDNMTYQAPQPQK
                     VRIQVTEDETGNHSTREAFAIHPQGIGNTKQPEDIGNIEQVMTESGISNALDENKGTID
                     YLTTDKHPNHHMIAFDVAGGTADVYDKKYAFISQNNGELNLVTPVGKKTKGIQFDAPDS
                     RYVQDQK"
                     /name="hypothetical protein"
     gene            complement(2446..2979)
                     /locus_tag="HXC01_RS00020"
                     /old_locus_tag="PPI1_p04"
     CDS             complement(2446..2979)
                     /locus_tag="HXC01_RS00020"
                     /old_locus_tag="PPI1_p04"
                     /function="unknown"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850931.1"
                     /GO_component="GO:0009986 - cell surface [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing protein"
                     /protein_id="WP_011152932.1"
                     /translation="MKTKQLLSTTAIAGTLLLSGLHAPQAKAESNINGSNAVDIIQQVD
                     KQHGNQPDLIRYGQPKDHGDYYEVTTNNKSGVGGAGITRLYKDGTVKHSTDSSGQDFKT
                     FGHYEDASYQSSSHDQNTPQASTTQHTEQTQHDTTDQTLPETGQSHTGITTMISIIALI
                     AGIGFIARRASHQA"
                     /name="LPXTG cell wall anchor domain-containing protein"
     gene            complement(3089..3445)
                     /locus_tag="HXC01_RS00025"
                     /old_locus_tag="PPI1_p06"
     CDS             complement(3089..3445)
                     /locus_tag="HXC01_RS00025"
                     /old_locus_tag="PPI1_p06"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_237624439.1"
                     /translation="MKSISFTRFYWGLIKLEDRFTERHNQWIREKRGKVYADDRYALNY
                     NHRNGHWTATNIDAEKRNRRVELGNVAWFIAMGYLGFLFFFVGVYMIIMYFIIVPVAIG
                     VVLHMYYKYQTFQR"
                     /name="hypothetical protein"
     gene            complement(3733..4212)
                     /locus_tag="HXC01_RS00030"
                     /old_locus_tag="PPI1_p07"
     CDS             complement(3733..4212)
                     /locus_tag="HXC01_RS00030"
                     /old_locus_tag="PPI1_p07"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000527036.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_039258943.1"
                     /translation="MGNKVQRTLTIYTKLRDHRYVNVPLLAETFHVHPRSIQRDLEDIR
                     DFLNDQHQHLLYDHHTQNYYMSHQTMTDDQVTPTSVTYEMTHQLYQQLQHHYQTYVLKN
                     DAHKMLVTFQMAPSEAIHFCFTYRHALRLVSPDTLFAQFTTELIQLQMIYMKGAL"
                     /name="hypothetical protein"
     gene            4839..5114
                     /locus_tag="HXC01_RS00035"
     CDS             4839..5114
                     /locus_tag="HXC01_RS00035"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_176446082.1"
                     /translation="MKIWKLSILFKIGYFLVKKVTGAFSGYFSSNIESRYWILTLGALG
                     ATQLEQVSEASGQKASAMLSDTEGGIVVPYALYRVTFFKVLGIQKS"
                     /name="hypothetical protein"
     gene            6201..7433
                     /locus_tag="HXC01_RS00040"
                     /old_locus_tag="PPI1_p10"
     CDS             6201..7433
                     /locus_tag="HXC01_RS00040"
                     /old_locus_tag="PPI1_p10"
                     /function="unknown"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002487366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_011152938.1"
                     /translation="MEIKEYFEIANTILRWLSIFVIPLFGIIISKLVDRNNIMNPNKEK
                     LGRLFKNILRFIGLVILLDILMFLSISEIFSEVKNINSIQSDLWSAFYIFTAFNVVYAI
                     FLFPLFIKEKKYYEVELTHNNKKMKYIVRDRVEDKDDGKLIYVDEDENKEYEENISDIK
                     KRESRVTFIPHVVALFSINKDALKETKVFPMWLRWSLFIILVGADTYIAITCLKALYDL
                     WRWDFGKLLIPFRIFLSTFPVVLVLEITVLVVFLYKTWLGKNKLEYHNKKKDDSEMKLN
                     EEEAFRMISLLKSEFRGVRNKTPEIMKDDTLNYQQKKQQLDDIENKCVKNVFRYSEINK
                     DFVYGLSSLLISYKVGTNGREQAYRNFITQYVNGNVEELIQFMNRELLGEYDHAIRRHQ
                     ILIEMFMEKRE"
                     /name="hypothetical protein"
     gene            7573..7668
                     /locus_tag="HXC01_RS00045"
     CDS             7573..7668
                     /locus_tag="HXC01_RS00045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_107549835.1"
                     /translation="MLEILVHITTTVISGCIIALFTHWLRNRKEK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            7844..8434
                     /locus_tag="HXC01_RS00050"
                     /old_locus_tag="PPI1_p11"
     CDS             7844..8434
                     /locus_tag="HXC01_RS00050"
                     /old_locus_tag="PPI1_p11"
                     /function="unknown"
                     /inference="COORDINATES: protein motif:HMM:NF037207.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SLATT domain-containing protein"
                     /protein_id="WP_011152939.1"
                     /translation="MSKDYISLNIKEEINKKIYSIDKVRNARINASKRLENYANQWNFL
                     FFLLNVLAVIFVLSALVLISNNAFSFVASCYSLYVILLQYYISIQNYKERALRFHYHQL
                     QLEDAIIQLKILIFNYYEYSDNKIIEQYKEIMNQHNLKLTNIENHSDRDFLLGNAKNSK
                     PYKKEVNIDKFILFMNYFVLLCLLTYYMFFLIF"
                     /name="SLATT domain-containing protein"
     gene            8444..9901
                     /locus_tag="HXC01_RS00055"
                     /old_locus_tag="PPI1_p12"
     CDS             8444..9901
                     /locus_tag="HXC01_RS00055"
                     /old_locus_tag="PPI1_p12"
                     /function="unknown"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_011152940.1"
                     /translation="MDKKLVLDIAYNYVITVARSKPYNIQMKAILNEFNNKSIDINSYI
                     KTFENFINNNEAFICKDFVYKNNLATYRKFYIVSPSLYLYYTYQTFELYFDIIPKNNIF
                     NYSHIDIFYSGIVNEDFKAIKKNCDFNNQYEEYKNKQAEYKNNYVLITDIANFFDSINV
                     DALLSKCNSLVFSYRGKDAINNLKDLFMEFNIASLPQLHYSIASSLLSQIYLVDMTRKA
                     DQLLQQNNWCGVRFVDDFCINLNKKFTYKDINKFLHEYSNLLYKESLNLNLSKTKRLTP
                     KNFEKLISTNKDKSGYDENIKSIEEYLNIKKGKYSVNDSIKKKANSLLEDAGNEFMKFI
                     VEVKKIYKSYGLDIKRYNKKVDKYFSINKEDSSKVIKHFIFNQEWKKEISKIDLKTIIE
                     CKELIYFDPMNFTILYCLIHSYLNISNNSHFDKFNNFYDAPLRNLMIFEQLTIQGFVSK
                     QEFHKVKNSFQEIDKNAALFFEKYIFK"
                     /name="hypothetical protein"
     gene            11045..11617
                     /locus_tag="HXC01_RS00060"
                     /old_locus_tag="PPI1_p14"
     CDS             11045..11617
                     /locus_tag="HXC01_RS00060"
                     /old_locus_tag="PPI1_p14"
                     /function="unknown"
                     /inference="COORDINATES: protein motif:HMM:NF028235.4"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_011152942.1"
                     /translation="MSKKLEILTIAREVIHSKGYKATSISDILNAADIGKGQFYYYFSS
                     KRDLGLAVIDDLVEDWTEQLINNKLHKSENPKENLNAMLDWTFKYHDDMNSKAGCPVGN
                     LAIEMSEHDEIFREKIQVFIDKWILSMKENLDRLKEQQFIENLDTEKHAQAIFSAIEGA
                     IMLTKVQKSVEYLKNVIEIIKWQYNLS"
                     /name="TetR/AcrR family transcriptional regulator"
     gene            11700..12653
                     /gene="trxB"
                     /locus_tag="HXC01_RS00065"
                     /old_locus_tag="PPI1_p16"
     CDS             11700..12653
                     /gene="trxB"
                     /locus_tag="HXC01_RS00065"
                     /old_locus_tag="PPI1_p16"
                     /EC_number="1.8.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002483616.1"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004791 - thioredoxin-disulfide reductase
                     (NADPH) activity [Evidence IEA]"
                     /GO_process="GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="WP_011152944.1"
                     /translation="MAEQVDFDVAIIGAGPAGMTAAVYVSRANLSTVMIERGMPGGQMA
                     NTEEVENFPGFEMVTGPDLSTKMFEHAKKFGAQYQYGDIKSVEDKGDYKVINLGNKEIT
                     ARAVIISTGAEYKKIGVPGEQDLGGRGVSYCAVCDGAFFKGKKLFVIGGGDSAVEEGTF
                     LTKFADNVTIVHRREELRAQKILQDRAFKNDKIDFIWSHTLKTINDKDGKVGSVTLEST
                     KDGSEQTLDADGVFIYIGMKPLTTPFLDLGITNDVGYIETNEDMSTKVSGIYAAGDVRD
                     KGLRQIVTATGDGSIAAQSAIAYIEHLNDQSEILSI"
                     /name="trxB"
     gene            12862..13521
                     /locus_tag="HXC01_RS00070"
                     /old_locus_tag="PPI1_p17"
     CDS             12862..13521
                     /locus_tag="HXC01_RS00070"
                     /old_locus_tag="PPI1_p17"
                     /function="unknown"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011067173.1"
                     /GO_function="GO:0051920 - peroxiredoxin activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_011152945.1"
                     /translation="MLQNDSLYKRSHTKRLVEFTKLSHDSFKSFIEFDHQVLSEGHLSK
                     KFKEVISIAVAHTTGCPHCIDHHVKQFKKLGGTKEEMAESIMVATALKAGSAMAHSVNT
                     LNAYDEIEDDELYKASYFKRLKELGQLDGERFKAFINFDQQAMKAGLLTVKEKELIAIA
                     VAHTTGCPYCIDIHTKSAKKAKVTKEEVAEAILVATLLKAGSAMSHGVNALNAYDE"
                     /name="carboxymuconolactone decarboxylase family protein"
     gene            13693..13827
                     /locus_tag="HXC01_RS00150"
     CDS             13693..13827
                     /locus_tag="HXC01_RS00150"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_272900939.1"
                     /translation="MTFNVDTEIEDLKIKELMHDALSISVVGNTIQSKVQINPEYKRK"
                     /name="hypothetical protein"
     gene            13885..14199
                     /gene="trxA"
                     /locus_tag="HXC01_RS00075"
                     /old_locus_tag="PPI1_p18"
     CDS             13885..14199
                     /gene="trxA"
                     /locus_tag="HXC01_RS00075"
                     /old_locus_tag="PPI1_p18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020808024.1"
                     /GO_function="GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="WP_011152946.1"
                     /translation="MATITVTEKTFNKTIEKGVTLVDFWATWCPPCQMQSPVLEELSDE
                     LEGKVIIGKVDVDEEKALAAKYQIQSIPTLLIFKDGELVNTLIGFNPKPNLENVLTKYL
                     "
                     /name="trxA"
     gene            14261..14581
                     /locus_tag="HXC01_RS00080"
                     /old_locus_tag="PPI1_p19"
     CDS             14261..14581
                     /locus_tag="HXC01_RS00080"
                     /old_locus_tag="PPI1_p19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002483611.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin family protein"
                     /protein_id="WP_011152947.1"
                     /translation="MEKVMSYNDLLYKIGRNDKLLLYVMSENCSVCHADFPKVEALDKK
                     YNLNSLNIMVNEIPEAVGQLSLFTAPVVILFYKNKEIHRQARIIDFEELEYRIKQLNEI
                     EN"
                     /name="thioredoxin family protein"
     gene            14655..14780
                     /locus_tag="HXC01_RS00155"
     CDS             14655..14780
                     /locus_tag="HXC01_RS00155"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_259677158.1"
                     /translation="MHNNQYEPFSVEDIEEYDEKMQSYYKNRPIKAPFSTRTVKG"
                     /name="hypothetical protein"
     gene            15040..15618
                     /locus_tag="HXC01_RS00085"
     CDS             15040..15618
                     /locus_tag="HXC01_RS00085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690630.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNQYGCEKIFSDHISGAKSKRPGL
                     DRAIEFARSGDTIVVWRLDRLGRNMADLITLVNELNNRGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLTLLKTLYDNGTPI
                     KTIAEQWKVSRTTIYRYLNKLNNQENKDK"
                     /name="recombinase family protein"
     gene            15749..16357
                     /locus_tag="HXC01_RS00090"
                     /old_locus_tag="PPI1_p21"
     CDS             15749..16357
                     /locus_tag="HXC01_RS00090"
                     /old_locus_tag="PPI1_p21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_011152949.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLRTFGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEVINTVNYLKDKEVQLMITSLPMMNEVIGNLL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKRVYKGRPQLYSPNAKDPQKRV
                     IYHRVVEMLEEGKAISKIAKEMNITRQTIYRIKHDNGLS"
                     /name="recombinase family protein"
     gene            16512..16640
                     /locus_tag="HXC01_RS00160"
     CDS             16512..16640
                     /locus_tag="HXC01_RS00160"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_260841828.1"
                     /translation="MAEERENKIDFVDKLLVFYAQEKYPKILEAFKKQELKIQKRN"
                     /name="hypothetical protein"
     gene            16730..>17035
                     /locus_tag="HXC01_RS00095"
                     /pseudo=""
     CDS             16730..>17035
                     /locus_tag="HXC01_RS00095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000583527.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /name="recombinase family protein"
     gene            complement(17479..18222)
                     /locus_tag="HXC01_RS00100"
                     /old_locus_tag="PPI1_p23"
     CDS             complement(17479..18222)
                     /locus_tag="HXC01_RS00100"
                     /old_locus_tag="PPI1_p23"
                     /function="unknown"
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_011152950.1"
                     /translation="MKKINAIIIDDNASTREDLKVNLSYFSFVSCKGTFSEYIEAKNTL
                     DKKDIDLIFLKINTNNNKFIDIANNINSIHKHIQIVFLSSDSKHAHKSFEAHPFDYLIQ
                     PVEPIKLEKCLLHFKNRCRKKFDLNNLKNRKIAIKKGKSLYFLEIDKITTAECCGRKII
                     ITLDDKETVSYNGSLKYLEKKLYSYGFILVSRSLLIPLKSIKNIIFDKHSKCYILKSIK
                     NNTVKITPEKYKKVKQTLSEFNWII"
                     /name="LytTR family DNA-binding domain-containing protein"
     gene            complement(18649..18822)
                     /locus_tag="HXC01_RS00105"
                     /old_locus_tag="PPI1_p24"
     CDS             complement(18649..18822)
                     /locus_tag="HXC01_RS00105"
                     /old_locus_tag="PPI1_p24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011152951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_011152951.1"
                     /translation="MENSKVMKDIEVANLLEEVQEDELNEVLGAKKKSGVIPTVSHDCH
                     MNSFQFVFTCCS"
                     /name="lacticin 481 family lantibiotic"
     gene            19224..21977
                     /locus_tag="HXC01_RS00110"
                     /old_locus_tag="PPI1_p25"
     CDS             19224..21977
                     /locus_tag="HXC01_RS00110"
                     /old_locus_tag="PPI1_p25"
                     /function="posttranslational modifications of prepronukacin
                     ISK-1"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_011152952.1"
                     /translation="MNNIKVEQFRGFSNFILKKYSKQELNTLIDWNYLRSIILDICGKS
                     LIVLINEKRLNKKLNGNTPEERYKYFDEELCEKGIIYEELNKSYPSIINDLEQTLNSYF
                     SFLKEIENKFNQEKKKLLEANLIKTEKETICHISILGDLHGGKAVTKVTTDKSQLLYKP
                     RSLENDSFFLEFLEFMYSFQKNEISTYYKYKFIDYKDHGWMEYIEKQPTSKNKINMYYK
                     RLGYLLSIGYLLNISDLHFENILCSSNFPILIDLETIFHTSIYESKFRNLATKNIEDKA
                     ANSVFATGMLPISKKDKKYGGDISGILGGVFNKHERTISNPNRDDIKFEKRLVRVKRND
                     HIPFYMENDKKRRFSPEVFIEDIQEGFKYGYELFLNNRKEILHYIKKTSSEVEVRILPR
                     STIEYSVLIQAAKSPLYANKRKSLFNKLEEYGENLLSDKLINSEIKQIETLSVPYFYTK
                     VQSVSVKDIKNNTVHHLLKNPLNVFLEKTQRYSLKDLLFQCKLIKFSLESQNKLFIDGN
                     GFINYEYEIVNSDNIDDAIDNLVSIIINNAVIDEKDGSVNWMNLGISKEEEIIFESLSD
                     DLYKGLSGIGIALLKYYEINKNLKDMSRLKKILSSIYSSILSNINTNSSKEKDLSFFNG
                     EIGKIAFLYKYQIEFKENCDSSKNYMKHILGIILSSEFEMNDIIAGLPGIISYLYNQEI
                     FSKELVIMGDRLLKDLDNNPTMASYAHGKSGVMVSLLYLYDLTKDKKYLVKFHQEWKKE
                     NTLKLEIGWKDVRQNEETYSVSWCNGVTGQLISRLVALEIHDKVKIFDAVNKKLMQKEI
                     EELLYLLKEEGLEQNNFCLCHGVMGNLLVLNYYQKKFENTNIHLANKIDSHFYSVANFG
                     LNKGWICGLGNNFYSFSIMTGISGILYAFLKYKTKDTELGILLPNI"
                     /name="type 2 lanthipeptide synthetase LanM family protein"
     gene            21999..24083
                     /locus_tag="HXC01_RS00115"
                     /old_locus_tag="PPI1_p26"
     CDS             21999..24083
                     /locus_tag="HXC01_RS00115"
                     /old_locus_tag="PPI1_p26"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0008233 - peptidase activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_046466871.1"
                     /translation="MKIALQNSDQDCLLACYSMILSYFGKNVSINSLYKREMIPPDGLS
                     ISYLKELNIKYELNMKVYRIKDKEKTFRVISKIKKPIIVHWDLNHFVIVKNVKKKHIEI
                     VNPEIGKVKISKEMFLEHFSNVLLMFDPKSDFTKDKEKIEFFDDLKSVLMNKNIILFSF
                     SVMLAQIVALIFSIVVRDIINQKYTYLISLSMLLMMIIIQIFSLVFKQKAQIKENKIYE
                     KIISYNMFEGLFNKPLLYFRNSTIGTLMEKINIKTTIRDNILLKILPSFLNFFSVTVLF
                     IYLLTVSLLLSLLLLGMSIIYLLISVFIYIKKNQLNIEYMQRTIQFSSLAQESLSQIDQ
                     IKAQAQESSTINNWKEKSWNIVNSYNSILKIEGLSYTFNQIFNYSSIILLMIFGIHLTK
                     YGNITIADLILFQSGMSIFSSSVSQLQDITFEISKIKVSGEKINDLFLKNNTKRKVIEQ
                     KSNNALSLKNVTFGFDEKAPILKNITFQVKKGEKVAIVGDSGSGKSTMLNVLLGLYTCD
                     GEVVYGYRDFRKITGVVLQNMTLSKQSIYNNLVDEGNDSNMQKLNQILYDVNIINLINS
                     LPNKIYSSVFQNGKNLSGGQIQRLLIAKSLFNKKLIFWDEAFSSLDNYNRINIYRNVLK
                     NSQYSDKTIVLISHHLDVLSYVDKVMFIENGNAFFGTHNELIKNNKNYRRFLDTANTNN
                     "
                     /name="cysteine peptidase family C39 domain-containing
                     protein"
     gene            24096..24971
                     /locus_tag="HXC01_RS00120"
                     /old_locus_tag="PPI1_p27"
     CDS             24096..24971
                     /locus_tag="HXC01_RS00120"
                     /old_locus_tag="PPI1_p27"
                     /function="immunity to the lantibiotic nukacin ISK-1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002281774.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_011152954.1"
                     /translation="MINNIVQTQNLTKKFSDSYSVDNLSLNIGSKEIYGFLGPNGAGKS
                     TTMKMLLGLMQPTKGNIKIFNQDISKNRDEILMHVGALIEEPSYYKNLTGLENLQVIQR
                     LLNLPSKNVKEALKIVRLTEHKDKLVKNYSLGMKQRLGIALAIVKFPKLLILDEPTNGL
                     DPSGIQEIRELIKSFPKTYGMTVLISSHLLSEIEHMANTVGIINRGKLLFEGKLTELEE
                     QNKILINTNNNSESINLLQSKGYNLENNEKPLLLDTTQKDISTAVKLLVNNKFEIYQVQ
                     SVQKSLEENL"
                     /name="ATP-binding cassette domain-containing protein"
     gene            25004..25756
                     /locus_tag="HXC01_RS00125"
                     /old_locus_tag="PPI1_p28"
     CDS             25004..25756
                     /locus_tag="HXC01_RS00125"
                     /old_locus_tag="PPI1_p28"
                     /function="immunity to the lantibiotic nukacin ISK-1"
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="WP_011152955.1"
                     /translation="MLKAINLEFFKMRRRKFILPILLITFVGILWFCAIAIKELNITDT
                     KYGIYMLISNILTIDSMIYPILIGILCSRLADIEHQGKTFQLLNTSKQSVFNLFTSKVG
                     VSLIILFVIDIIQLTTILLIANSHNISLKLEIISKFMLSFIIASFFLILIHMALSFFFE
                     KQSVSIVSALVGSFLGLVTGGMLPSYIKIFLPWQYYSLLNPVHKKMVHKGYEYSNNDYY
                     FIYIFISILVIVILFFIIKALIKRRDLN"
                     /name="ABC transporter permease"
     gene            25753..26490
                     /locus_tag="HXC01_RS00130"
                     /old_locus_tag="PPI1_p29"
     CDS             25753..26490
                     /locus_tag="HXC01_RS00130"
                     /old_locus_tag="PPI1_p29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002455784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="WP_046466873.1"
                     /translation="MISLLSIELRKLQNNYILIFLLVFNILSVSIGSMIFYFNQSAFPN
                     SNNRDLILWGQETLYTSQLFFPILIGVLCSISWQFEESNNNWMRMKTIPLKESKIVLSK
                     FLSLFLLTLLNQIIFFVLFCISASIVNVSLEGLLKFLYWDFIGWIGTASIVAIQLYLSV
                     ATRNFTFSILISTIGGVLGLLTLFISNFIFKIFPYSQITVGVRARSLMNFTFSEMLLFL
                     IINVAYITVFLTLTTLKLKKREG"
                     /name="ABC transporter permease"
     gene            complement(26884..27084)
                     /locus_tag="HXC01_RS00135"
                     /old_locus_tag="PPI1_p31"
     CDS             complement(26884..27084)
                     /locus_tag="HXC01_RS00135"
                     /old_locus_tag="PPI1_p31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002448025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002485209.1"
                     /translation="MAGFLDDIDTSSVKYTENYKPISKSTTMRVDTNLKKRLSQMALDQ
                     DTSIKAIVDNVLNEFLEKKGY"
                     /name="hypothetical protein"
     gene            complement(27090..27884)
                     /locus_tag="HXC01_RS00140"
                     /old_locus_tag="PPI1_p32"
     CDS             complement(27090..27884)
                     /locus_tag="HXC01_RS00140"
                     /old_locus_tag="PPI1_p32"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366803.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="WP_012818111.1"
                     /translation="MSVITVGNFKGGVGKTTVATILSYIASEQYGKKVLLIDFDPQGNA
                     TQIMKRTYVEAPEENESFIDMLRTGNLENSMIRLSSKLSLLPADSSLANLSDIISKTDI
                     LKKRYILKNVVEKIREMYDFDHIFIDVPPTINSDFTNNAVYASDYILMVFQTQQSAYES
                     SLSFVNFLRDRKNESNLPFELIGAVPVLIKRSGKVDEKILNMSKTAFSQALFENQIYQR
                     ERIKKFGAEGIRNKDMHDKKVIHMFNKVYIELVDRIQVIESE"
                     /name="ParA family protein"
     gene            28515..29768
                     /locus_tag="HXC01_RS00145"
                     /old_locus_tag="PPI1_p33"
     CDS             28515..29768
                     /locus_tag="HXC01_RS00145"
                     /old_locus_tag="PPI1_p33"
                     /function="plasmid replication"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002447421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_011152958.1"
                     /translation="MTKQRFTKLYKFLFEDSTFNKLSIKAKLLYALLTERQNLSKLSAK
                     QHGIQSQFIDDNGRLFSIYTNKELMNIINISEPTVINLKKQLIAFGLLEEIRLGKNKPN
                     RLYPKKPYDEYFYVHDVDEFYRLPHSLFSNPKYKNLKAETIVAYAVYLSRYEYSVYKNH
                     FSDKSGEIYCHFSNEKMAEFLGVSTRKVERIKKELVVSGLMINKRATFGKANNLYINLP
                     KPFHIKELKNCRVRNLKIVGTGTKKLSGSELKNCRTSNIDISNTDVSDTDISDTNDLND
                     TYEINKNTNYHSNHTNHQQTEFNNDALKFQVLEELPTQIKIYLSNFEIKDIRFIKSVLL
                     KGKKSFNNVHDTYYRLEDVEFELVSVLKRFKAMLLQKNETVETMQGYLMQSIKAELEEI
                     HVLNMRRQNIPHYNIFNQ"
                     /name="replication initiator protein A"
     BGC             9224..30201
                     /name="lanthipeptide-class-ii"
                     /gene="lanthipeptide-class-ii"
                     /tool="antismash"
     Typing          28516..29768
                     /name="rep_cluster_418"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 gctagctttt tatttcaata cagtattaat ttttatatct gcgccacaac gctgattaat
       61 taaaagtaag ataaaaaatc gacgaaggtc gatgttggta aaatgaaagc tacatatctt
      121 tataaaatat cgatttaaat ccattgtcgt gtcattgtcg tggctatttt ttaagatgag
      181 gagtaattta atactatgaa tcaatcaaaa atcgcaaaat taagaaaaga caaatcgtta
      241 acgcaagaaa acttagccga aaaggcttgt gtcacagtaa gaactattca aagaatagag
      301 gcaggtgaag aagttagtag cgaaacactt aaaaatattt cgaatgtgtt agatgttacc
      361 atcaatgaac tctttgaatc gattgcgtcg tctgataagg aggaggaaat catggaaata
      421 gctaaagaac aacaaaagca gtttcattat cgtagaaatg aacaattgac gtttcgattc
      481 atcgcatttg gcgttatttt tgtattttta ggtttgtttg gtatttttgt agtaggatta
      541 aacgggttaa aacaagacat ttatggcgtt gtctggattt ttatgttgtt tttaagttta
      601 gctatgatgc attatgtttt aaatgtattg atatcaaaaa aattagatga aaaatatccg
      661 atgactgtgg gtatgaacca taaaagatct aatataaaac aggagcctat caaaaatggt
      721 tgggaattta tggctcgata ttggtggatc atttttccaa ttggcggctt tttaagttgg
      781 cttattcctg aattgacagg aaagtaaatc tcaaacaata aaaatatagt tgggaacatc
      841 gctttttatt atttgagtgt ttacaattga tatcacctgt tttaaaaggt tctcattttt
      901 gagtgtgggg tggatcagta actttttatg ccgagaaaat tgattgtcat tgagaagaac
      961 ccttaactaa actatatcga cgaatgtcgg tatagcgtga gctatgatac cgaccattcg
     1021 ataagcttcg ggattgttaa gggttcggag gctcaatgac aatcaaggaa ttggaataaa
     1081 taccagcgat gatgtgatga acgatgataa ataaaaaggt acctatacgg tacctaagtg
     1141 atatcacgat cataactttg gaaaacaaac cattcgatga gttcataggg atcgaatggt
     1201 gtaggtggat gtgtatatac caataagttg tgtctctggc agtgaatata aacagcgcta
     1261 gcgagtcgat ttaatgtatt cagctcatcc atatcggcat gattttgttc gactttttca
     1321 aataataaaa taacttcaac gatgtcataa ccgagttgtt caaggtacat ttgaatatga
     1381 tgatacatat gaaaggtctc ctttataatg aatacgccgt atcacaggat tgtgatacgg
     1441 cgttgattga tgtgatagac attcaatatt gattttttga gtaagataaa gctatttaga
     1501 tttatttctg atcttgaaca tagcggctat cgggcgcatc aaactgaatg ccttttgttt
     1561 ttttgcctac cggtgtaacc agattcaact caccattgtt ttgacttata aatgcatatt
     1621 ttttgtcata gacatcagcg gtaccacctg caacatcaaa ggcaatcata tgatggttag
     1681 gatgtttgtc ggttgtgagg taatcgatcg tacctttgtt ttcatctaaa gcatttgata
     1741 taccactttc cgtcatgact tgttcaatat tgccaatatc ttcaggttgt tttgtgttac
     1801 caatcccttg gggatgaatg gcaaatgctt ctcgtgtcga gtgattccct gtttcatctt
     1861 ccgttacttg gatacgtact ttttgaggct gaggggcctg ataagtcata ttatctaaat
     1921 gttttatggc tgtttcaggt tggatctgaa agtcacttgc tttgagttta aaatcatcat
     1981 gatcctctag ttgtttacga ttcacaagtt tttgtatttc ttgtttcatt tctttttttt
     2041 catattgaaa agcagcacga tcatcctttt tagccatatc aataatggct ttatttgatt
     2101 tgtctttaaa atcacctaac gtacgatcag atgcttgatc actactataa acggtttgtt
     2161 tgccattttg tgtcacaata taagctgtca cgacggaatt ttttgtcggt gttggattgt
     2221 cttctttttt gacgagatat gagatgtgtt gatcttgatg catcacgtca cctaatttaa
     2281 cgtgtgtttg attggctgct tggttatggt gcccacatcc cactaataag aaagcgagac
     2341 tgatcatact aatgatactt tttttcattg tgataactcc tttgcgtttt ggatataaag
     2401 aagcgatagc tcttcatatt gaagacctat cgctcagtta actgattaag cttggtgaga
     2461 agcacggcga gcgatgaatc caatacccgc tatcagtgcg atgatgctaa tcattgttgt
     2521 tataccagta tgagattgac ctgtctctgg taacgtttga tctgttgtat catgttgtgt
     2581 ttgttcagta tgctgtgttg ttgacgcttg tggtgtgttt tggtcgtgcg atgatgattg
     2641 atatgatgcg tcttcataat gaccgaaagt tttgaagtct tgaccactgc tgtcggtact
     2701 gtgtttaact gtgccatctt tataaagacg tgtgatgcct gcaccgccga cgcctgattt
     2761 gttattggtt gtcacttcat aataatcacc atgatctttc ggttgaccat aacgaattaa
     2821 atcaggttga ttgccgtgtt gtttgtccac ttgttgaata atatcaacgg cattcgatcc
     2881 attgatgtta ctttcagctt ttgcctgagg ggcatgtaaa cccgataata aaagtgttcc
     2941 cgcaatagca gtcgtactaa gtaattgttt tgttttcata aaatcgctcc ttgttaaatt
     3001 aataatattg atgattactt gatctcaata atcaaaaata aatcatcaat cgagacagcg
     3061 ttaaatacat ttaaattcct ccttactatc atctttgaaa cgtttgatat ttgtagtaca
     3121 tgtgtaagac aacgccgatg gcgacaggga cgataataaa atacatgatg atcatgtaga
     3181 caccgacaaa gaagaagaga aaacctagat atcccatggc gataaaccaa gcgacattgc
     3241 ccaactctac acgacgattt cgtttttcag cgtctatatt agtcgcagtc caatgtccgt
     3301 ttcgatgatt gtagttaagc gcgtatcgat catcggcgta gactttgcct cttttttcgc
     3361 gaatccattg gttgtgacgt tcagtaaagc gatcttcaag ttttattaag ccccaataaa
     3421 atcgtgtgaa gctgatagat ttcacaaaac ggatgtacgt taatgtgatt gggtataata
     3481 tcatgacgat gaaggtatat agatgcacga gttgcgtcat gatgggtggt gatgagagtg
     3541 ggacaaagaa aggttctttg ccaatctcaa atggaaaaac aatcgatacc aggatgatat
     3601 aacctcaaaa ccaacgtggg acgatttgaa agactgattg aacaaaatgt aagaaacttg
     3661 aggtatcgag ttgttgtgta ttttgatata aacgtagatg attgagttgc ttgagtgatt
     3721 gaaacataga ccttaaagtg ctcctttcat gtaaatcatt tgtagttgaa tcaattcggt
     3781 tgtgaattgc gcaaagagcg tgtctggtga tactaaacgt aatgcatgac gatatgtaaa
     3841 acaaaaatga atcgcttctg agggtgccat ttgaaatgtc acaagcattt tgtgtgcgtc
     3901 atttttgagg acgtatgttt gataatgatg ttgtaattgt tgataaagtt gatgtgtcat
     3961 ttcatatgtg acactcgtcg gtgtcacttg atcatcggtc atggtttgat gactcatata
     4021 ataattttgc gtatgatggt cgtataataa atgttgatgt tgatcgttta aaaagtcacg
     4081 aatatcttct aaatctcgtt gaatcgaacg tggatgaacg tgaaatgttt cagccaacaa
     4141 aggcacattg acataacggt gatcacgtaa cttagtatag atagttaatg ttcgttgaac
     4201 cttgtttccc acaatattgt cccccttatg atcttgatta taagcaaaac agacgacagg
     4261 tatcgtcgtc tgtaaaaaat taaaataggt atcaaattga atgatgttta tggtgtttaa
     4321 gatgattatt gaacaccatt tttgtgaaat gtttcgtgac aaatcgtgtc gttctgagac
     4381 agtgttaaat gacatgatag taatacgatt ggattaaaaa atagtcacgt aagtcatgag
     4441 aattgagcgc aacaacggtt aactctaaac ccaatttgag atcatcacgt aggtaacgat
     4501 agatgttttg aaagagttgt tgcatcgttg tgatttcatt ttgcgtggca cgatgttcaa
     4561 agattttttg acatatgatc gcgaccttca caggatcttt ttgatgtttg aacaagtact
     4621 gattcatgtg ttgatatacc atttatttca cctctattcg aaaaattttc aacgtttcaa
     4681 ctagaacgat gaccatcgtt cctatggttt tgaactttga aaaacgtctc aattttttga
     4741 acgaacatca tctccaaaaa gcaaacatgc attaaaataa cgaaagttac cggggtttaa
     4801 aaagttaccg agacgtcata aaacccatag cggcgcggtt gaaaatttgg aaattgtcaa
     4861 ttttgtttaa aattggctac tttttggtta aaaaagttac cggggctttt tcgggttatt
     4921 ttagctccaa tatcgaaagt agatattgga tcttaaccct tggggctcta ggcgcaacgc
     4981 agttggagca agtgagcgaa gcgagcggtc aaaaagcctc agctatgctg agtgacaccg
     5041 aaggtggcat cgttgtccct tatgctcttt accgagtaac tttttttaag gtgctcggta
     5101 tacaaaaaag ttagcgccgg agcacaaaaa agtgctttgg cggttacttg ttttctttga
     5161 aaaataggag tgaataacga gctattttga aaagttgaag gcgtgtttga gatatcatgg
     5221 catgctattt tagatgttgt tgaaatcatc agtgatcata tgaaaaagaa aaaaacgagg
     5281 acatgttaag acgtcaaaaa aggactttca atataaaaaa tgggcgattc aaatcaaaaa
     5341 aatgtgtgat acttttttgt atatatgaag caaatgaaac gatgtatggg cgtgtttgga
     5401 atcggtttta aaagttaaaa aatgacaatc aatgatcgat aagagcaagc caaaaaacta
     5461 ttttttgata aagtttaagc gcctttgatt attccatttt tgaatgttta aggtcagtga
     5521 atgaatccaa ataggatatt aaaatcattc aatgttattc atttttacgt cgtgtttttg
     5581 atgatttatg tgttcaaaaa tgaagtgatc atgattcaaa aaaggagctc aacggctcat
     5641 catttgtgtc ttattttaaa ttgaaacacg accatttttg atttaaaagt cacttaaaac
     5701 atatgatgtt tttggatttt tagtttgaag ttaaagacat cattgtggtc aaaaagaaaa
     5761 tatcaaaaat atcatcaagc atcgatatgt gactcaaaaa attatcataa aagtaaagtt
     5821 agatgcgata gattggatct aaaaatggaa gcatgttgat agcataaaat gattttttaa
     5881 gtttaaaaat aggatgtcag acgagagtgt tttaatttaa atgataactg ttaatatgaa
     5941 aaagtagtat gaaagtatat tgtagtaaag cgcaaaagga gtaggacaaa acactttttt
     6001 agttggtata atactcatta aagtttgaaa aactgagatg atagattttt gaaataaagt
     6061 tatccgaaca gaaatggtag ctatttaact tgataaatat gactcagaaa acattgaata
     6121 aacatcatat gttcttctaa tttactatat tggaatcata aaatgaatta aatataaata
     6181 acaatgaggt gtcaataggt atggaaatca aggaatattt tgaaattgcc aatactatat
     6241 tgagatggtt aagcatattt gttataccgt tatttggaat cattatatca aaactggttg
     6301 atagaaataa cataatgaat cccaataaag aaaaattagg tagactattt aaaaatatat
     6361 taagatttat tggtttggtt atacttttag atatattgat gtttttgagt attagtgaaa
     6421 tattttcaga ggttaaaaat attaattcaa tacaatcaga tttatggagt gcattttaca
     6481 tatttacagc gtttaatgtg gtatatgcta tatttttgtt ccccctattt atcaaagaaa
     6541 agaaatatta tgaagttgaa cttacgcata ataataaaaa gatgaaatat attgttcgtg
     6601 atagagtcga agataaagat gatggaaaac ttatatatgt tgatgaagat gaaaataaag
     6661 agtatgaaga gaatattagc gatattaaaa aaagagagtc aagagtgact tttatacctc
     6721 atgtcgtagc actttttagt attaataagg atgcattaaa agaaactaaa gtatttccta
     6781 tgtggctaag atggtcatta tttatcatat tagtaggtgc tgatacatat attgcaatta
     6841 catgcttaaa agcattatat gatttatgga gatgggactt tggtaaatta ttaataccgt
     6901 ttagaatatt tctttctaca tttccagtag tattagtatt agaaataaca gtactagtag
     6961 tattcttata taaaacgtgg ttaggtaaaa ataagttgga atatcataac aaaaagaagg
     7021 atgacagtga gatgaaatta aatgaggaag aagcttttag aatgatttct ttactaaaga
     7081 gtgaatttcg aggcgttaga aataagacac ctgagataat gaaagatgat actttgaatt
     7141 atcaacaaaa aaagcaacaa ttagatgaca tcgaaaacaa atgtgtcaaa aatgtatttc
     7201 gttattctga aattaataaa gatttcgttt atggtctgag tagtttattg atttcatata
     7261 aagtgggtac aaatggtaga gaacaagcat atagaaattt tataactcaa tatgttaatg
     7321 gcaatgttga agaacttata caatttatga atcgagaatt gttaggggag tatgatcatg
     7381 caatacgtcg ccatcaaata cttattgaaa tgtttatgga aaagagagag taatataaaa
     7441 ttttatttta atatagtttt taacataaaa tgacttatcg gaagtagata tgcttcaaaa
     7501 gatacaaatg atataatagt ggggtcgcct atctctcagg cgtcgagttg acgtagggag
     7561 gaggtgttat tcatgttgga aatccttgtt cacatcacga ccacagtcat cagtggttgt
     7621 attattgcgt tatttacgca ttggctgcgt aatcgcaagg aaaaataggc gacaatagcc
     7681 acacctacaa aaatcccctc actatttgca gtagtgaggg gattggtgta tccatgttgg
     7741 attccttgtt aagtttatta tagcactata gcggatagga atgcaaaata actatttaaa
     7801 aactgcattt actagaaaat caaaaaagaa agttgtgtga aaaatgagta aggattacat
     7861 aagtttaaat attaaagaag aaataaacaa aaagatatat tccattgata aagtaagaaa
     7921 tgcacgtata aatgcgagta aacgattaga aaattacgca aaccaatgga attttctgtt
     7981 ttttctttta aatgtattag ctgttatatt tgtattaagt gccttagttc ttatttctaa
     8041 taatgccttt tcgttcgttg catcttgtta ttcattgtat gttattttgt tacaatatta
     8101 tatttctata caaaattata aagaaagagc ccttagattt cattatcacc aacttcaatt
     8161 agaagatgcc ataatacaat tgaaaatttt aatatttaat tactatgaat acagtgataa
     8221 taaaataatt gaacagtata aagaaataat gaaccaacac aatttaaaat taacaaacat
     8281 agagaaccat agtgatagag attttttact tggtaacgca aaaaatagta aaccatataa
     8341 aaaagaagtt aatatcgata aatttatact gtttatgaat tattttgtac ttttatgttt
     8401 attaacatat tatatgtttt ttttaatatt ttaagggggg actatggata aaaaattagt
     8461 gttagatata gcatataatt atgtaataac tgtagctaga agcaaaccat ataatataca
     8521 aatgaaagct atacttaatg agtttaataa taaatcgatt gacataaact cgtatattaa
     8581 aacttttgaa aattttatca acaataatga agcttttatt tgcaaagact ttgtatataa
     8641 aaataattta gcaacatata gaaagtttta tatcgtatca ccttcattat atttgtatta
     8701 tacatatcaa acttttgaat tatactttga tataatccca aaaaataata tttttaatta
     8761 ttcacatatc gatatatttt atagtggaat agtaaatgaa gattttaaag cgataaaaaa
     8821 aaattgtgac tttaataatc agtatgaaga atataaaaat aagcaagcag aatataaaaa
     8881 taattatgtt ttaataacag atatagccaa cttttttgat agtattaatg tcgacgcact
     8941 tttaagcaaa tgtaatagtt tagttttcag ttatagagga aaagacgcaa ttaacaactt
     9001 aaaagatttg tttatggaat ttaatatagc ttcattgcct caattgcatt attcaatagc
     9061 atcttcttta ttatctcaaa tttatttagt tgatatgact agaaaggcgg atcaattatt
     9121 gcagcaaaat aattggtgtg gggtaagatt tgtagatgat ttttgtatta atttaaacaa
     9181 aaaattcact tataaagata taaataaatt tctacatgaa tatagcaatt tactttataa
     9241 agagagttta aatttaaatt tatctaaaac aaaaaggtta acaccgaaaa attttgaaaa
     9301 gttaatatca acaaataaag acaaaagtgg ctatgatgaa aatataaaat ctatagaaga
     9361 atatcttaat attaaaaaag gtaagtattc tgtaaatgat tcgattaaga aaaaggctaa
     9421 tagcctatta gaagatgctg gtaatgaatt tatgaagttc atagtagaag ttaaaaaaat
     9481 atacaaaagc tatggactag acataaaaag atacaataaa aaagtagata agtatttttc
     9541 aattaataaa gaagattcat ctaaagttat taaacatttt atttttaacc aagaatggaa
     9601 aaaagaaata agcaaaattg atttaaaaac tataatagag tgtaaagaat taatttattt
     9661 tgaccccatg aattttacaa ttctttattg cttgattcat tcatatctaa atatttcaaa
     9721 taatagtcat tttgataaat ttaataattt ttacgatgcg cccctcagaa atcttatgat
     9781 atttgaacaa cttacaatac aaggttttgt ttcaaaacaa gaatttcata aagttaaaaa
     9841 tagtttccaa gaaattgata aaaacgcagc actttttttt gaaaaatata tttttaagtg
     9901 attttaacga tatttatgaa gtatatgaca tcttagtatt tcaatgtaaa agaaaacttc
     9961 atcaagagtt gcaaaactta tgaagttttc taattatggt acattgatta tagaacaagt
    10021 tttaatacta aaacttgcag gaaaaagctc tatctttgtc attttacttg atattcgaaa
    10081 atgatttcac ctaataaata agaaagtgaa atatttattt agttatacta tttttaatat
    10141 cactttgata acaatacaag acttctagac gctgtgagag tccttcattt gcatcgcgaa
    10201 atattacatc aaggtatttt gttaacgaca tataaaatta tttaatagat tcattttagt
    10261 aaaattgatt cgttgcttta cttgtcttat tctcttttct atctaattta ttgataggtt
    10321 tatcaatagt aaattcatca aaatctgttt ttgccataca aaattatata taagttgtaa
    10381 tttttattgt ttagcgcata aaacctttga tgaaatcaat tatttgttct ctaaatataa
    10441 tgaataattt taaagtatac ataatcaata agattggtgt taatattata aataaatctg
    10501 tgaaatcgag ttgagtattc ataggtttag acaacccttt agatacgaat ttattaattt
    10561 caaatccaga tgttattaat atagatgtaa tactaattac agccatagct attaaaatat
    10621 agtgcttaac aaaagtaaca acttgataaa ataagattaa aaaggttgta aataattatc
    10681 taaagagttt tatcaagaaa ttctatatcc tttatatttt aatgaataat taaaattgtt
    10741 aatttaaggt acaccctaat catacagaca cagttgttga atttataaca actgtcactg
    10801 tacttggtat atgagaataa ttttacttaa taaatgagaa agcgcagtac actcactgct
    10861 ttaagattgg ctaataagat attattacta atataaaatt tgattcttgt ttaattatga
    10921 atactagact tatgggttga tttttagttt agaaagagtt attatatttt ttgtaccgac
    10981 cggtaggttt aaaaataaaa agtaagtatc atactttctt ttagtaataa ggtggtaagt
    11041 agttatgtca aaaaaacttg agatattaac aattgcccgt gaagttatac attcaaaagg
    11101 ttacaaggct acttctatca gcgacatatt aaatgctgct gatattggaa aaggacaatt
    11161 ttactattac ttttcctcta agagagattt aggtttagca gtaatagacg atttagttga
    11221 agattggact gaacaactaa taaacaataa acttcataaa agtgaaaatc ctaaagagaa
    11281 tttaaatgct atgctagact ggacctttaa atatcatgat gatatgaatt caaaagctgg
    11341 atgtcctgtg ggaaatcttg caattgaaat gagtgaacat gacgagattt tcagagaaaa
    11401 aatacaagta tttattgata aatggatact ttcaatgaaa gaaaatcttg atcgcttgaa
    11461 agaacaacag tttatagaaa acttagatac agaaaaacat gcgcaggcta ttttttcagc
    11521 tattgaaggt gcaattatgt tgactaaagt acaaaagagc gttgaatatt taaaaaatgt
    11581 gattgaaatt ataaaatggc aatataattt atcataattt atcattttca tattatcgat
    11641 tgttaaattt tgacattcag ataatatgaa aaatcattta atgaatggag gcaatataaa
    11701 tggctgaaca agtggatttt gatgttgcaa ttattggcgc tggaccagca ggtatgacag
    11761 ctgctgttta tgtatcacgt gcaaacttaa gtactgtaat gattgaacgt ggtatgccag
    11821 gcggtcaaat ggcaaataca gaagaagttg aaaacttccc tggttttgaa atggtcacag
    11881 gaccagattt atcaacaaaa atgtttgaac acgcgaaaaa atttggtgct caatatcaat
    11941 atggtgatat caagtcagtt gaagataaag gtgactacaa agtcatcaac cttggaaata
    12001 aagaaataac agcacgcgca gtgattattt caacgggtgc tgaatataaa aaaattggtg
    12061 taccaggcga acaagacctt ggtggccgtg gtgtaagtta ttgtgctgta tgtgatggtg
    12121 cattctttaa agggaaaaaa ttattcgtta tcggcggcgg agattctgca gttgaagaag
    12181 gaacattctt aacgaaattt gctgataatg taactattgt tcaccgtaga gaagaattac
    12241 gtgcacagaa aatcctacaa gatcgtgcat ttaaaaatga taaaatcgac tttatttgga
    12301 gccacacatt aaaaacaatt aatgataaag atggcaaagt aggatctgta acgttagaat
    12361 caacaaaaga tggttctgaa caaacattag atgcagatgg tgtgttcatc tatatcggta
    12421 tgaaaccatt aacaacacca ttcttagact taggtattac aaacgacgta ggttatatcg
    12481 aaacaaatga agatatgagc acaaaagtat ctggtatcta tgcagctggt gatgtgcgtg
    12541 ataaaggctt acgtcaaatc gtaacagcta cgggtgatgg tagtattgct gcacaaagtg
    12601 ccattgctta tattgaacat ttaaatgatc aaagtgagat actatctatt taatccttat
    12661 ttttaaaatg aaagactaat ttattgcttt taaatttaga ataagttatt gtattttatg
    12721 taccgaccgg taggtatttc atattaggaa ctataataat ctaccgagga gaagcataac
    12781 aattgaaaat aacacataaa aagatttagc tttaaaataa ttgtaccaac tagtaggtac
    12841 acaattaagg gagtttttga aatgttacaa aatgatagtt tatacaagag gtcccataca
    12901 aaaagattgg ttgaattcac aaaactttct catgattctt ttaaaagctt tatagaattt
    12961 gatcatcaag ttttatcaga aggtcattta agtaaaaagt ttaaagaggt tatctcaata
    13021 gcagtagcac atacaactgg atgtccacat tgtattgatc accatgttaa gcagtttaaa
    13081 aaattaggtg gtacaaaaga agaaatggct gaatcaatta tggtagcaac tgcattaaaa
    13141 gctggttctg ctatggcaca tagtgttaat acgctaaatg catatgacga aattgaagat
    13201 gacgaactat ataaagcttc ttattttaaa aggttgaaag aacttggaca attagatgga
    13261 gaacgtttta aagcatttat aaactttgat caacaagcaa tgaaagcagg actattaact
    13321 gttaaagaaa aagaattaat tgcaattgca gtggcacata caacaggctg tccatattgc
    13381 attgatattc atactaaatc tgctaaaaaa gcaaaagtta caaaagaaga agttgcggaa
    13441 gcaatattag tagcaacgtt attaaaagca ggttctgcaa tgtcccatgg tgttaatgcc
    13501 ttaaatgcat acgatgaata aataacttac gtggcatacc ccattgatta taggaggaaa
    13561 ttataaataa caaacaacag ttcgaacctt tattccaacc atttaatcta ggaaatttga
    13621 acttaaatat tatcagctaa taacaaaaat catgaaataa aagagggaaa tcttgatgtt
    13681 tataatttga atgtgacttt taacgtagat actgaaatag aagatttaaa aatcaaggaa
    13741 ttgatgcatg atgctttatc aatttctgta gtaggaaata ctatacaaag taaagttcaa
    13801 ataaaccctg agtataaacg taagtagagt tagtaattga aaatgagaac taactgaatt
    13861 caattaaaag gagatttaaa agatatggca acaataacag taactgaaaa aacatttaat
    13921 aaaacaattg aaaaaggcgt aacacttgta gacttttggg caacttggtg tccgccttgt
    13981 caaatgcaat cacctgtatt agaagaacta agtgatgagt tggaaggtaa agtaataatt
    14041 ggaaaagtag atgtcgatga agaaaaagct ttggctgcta aataccaaat tcagagtata
    14101 ccaacactat taatctttaa agatggtgag ttagttaaca ctttaattgg ttttaatcct
    14161 aaaccaaatt tagaaaatgt attaactaaa tatttgtagt taattttaaa ttggaggaaa
    14221 ttgataatac aaaaataact ttagaaggag ctgtataagg atggaaaaag tgatgagtta
    14281 taatgactta ttgtacaaaa taggtagaaa cgataagcta ctattatatg taatgtctga
    14341 aaattgtagt gtttgtcatg ctgattttcc taaagtagag gcattagata aaaagtataa
    14401 tttaaacagt ttgaacatta tggttaatga gataccagaa gcagttggtc aattatcact
    14461 atttacagct ccagttgtta ttttatttta taaaaataaa gaaatacatc gacaagcaag
    14521 aattattgat tttgaagaat tagagtatcg tattaaacaa ttaaatgaaa ttgaaaatta
    14581 gtacatgtca aaatgctctc ctaaattctt tgggagagca tttatatcat cgatgattac
    14641 cgaaagatat tgtcatgcac aataatcaat atgagccttt cagtgttgag gatattgagg
    14701 aatatgatga aaaaatgcaa tcatattata aaaatagacc aatcaaagca ccattttcaa
    14761 cacgaacagt caagggatag agtgagcata tcaatgagca cttagctaga agctatgacc
    14821 ctaatatgct tgattattta aatactcaag catatatata aataattttt ataaacgagt
    14881 gtacagaaaa taaccatttt ctgtacactc tctttttata tctatatata gctagtatac
    14941 atattttagt gttcaataac ccaacacaaa atctatgttc ataaataggg ttagaattaa
    15001 gttatggtac aataaaaatg tacataggag gtttgtattt tgaaaatagg ttatgcaaga
    15061 gtttcaactg gtttacaaaa tttgaatttg caggaagatc gattaaatca atatggttgt
    15121 gaaaaaatat ttagcgatca cataagtgga gcaaaaagta aacgtcctgg tttagataga
    15181 gccattgaat ttgcgaggtc aggagatacg attgttgttt ggagactaga tagactagga
    15241 cgtaacatgg ctgatttaat cacattagtt aatgaactta ataatcgagg cgtgagtttt
    15301 catagtttag aagaaaatat aacaatggat aaatcaagtt ctacaggaca attgttattt
    15361 catttattcg cagcatttgc agagtttgaa cgtaatttaa ttttagaacg ttcttcagcg
    15421 gggcgaattg cagctcgtgc tagaggacga tatggaggtc gacccgaaaa attaaataaa
    15481 caagatttga ctttactcaa aacactttat gataatggaa ccccaattaa aactattgca
    15541 gagcaatgga aagtttcacg tacaacaatc tatcgttatc tcaataagtt aaataaccaa
    15601 gaaaataaag ataaataaaa atattactaa gttttaagaa agttaaaaaa ctagacagga
    15661 tacaccctaa tcatacaaag agagttattg aatttatagt aacttaaacg tatgattagg
    15721 gtgtatatta attgtggagt gaaaatgaat gattataggt tatgcaagag tatcttcgat
    15781 agatcagaat ttagagagac agctagataa tttgagaaca tttggcgtag agaaaatatt
    15841 tacagagaaa caatcgggaa agtcagtaga aaatagaccc gtatttcaag aagcacttaa
    15901 ctttgtgaga atgggcgata gatttgtagt agaatcgatt gatcgcttag gtcgtaatta
    15961 tgatgaagtg attaacacag ttaattattt aaaggataaa gaagttcaat tgatgattac
    16021 tagtttacct atgatgaatg aagtcatcgg caatctttta ttagataagt ttatgaaaga
    16081 tttaatcata caaatattag caatggtttc agaacaagaa cgaaatgaaa gtaaacgtcg
    16141 acaagctcaa gggattcaag ttgcgaaaga aaaaagagtt tataaagggc gaccacaatt
    16201 atattcacct aatgctaaag atccacaaaa acgtgttatc tatcatcgtg ttgtggaaat
    16261 gttagaggaa ggcaaagcga ttagtaaaat tgccaaagaa atgaatataa caagacaaac
    16321 gatttataga attaaacatg acaatggttt gagttaataa atggtttttc aatgcaaatg
    16381 agagcttctc acagcgttct aaaacgcata ttaatcatct attatgagat tttaataata
    16441 aaacaagaaa agagagtgta aaaactacct ctcttttctt ctatattctt tttctcaaaa
    16501 gtgatgaatt agtggctgaa gagcgagaaa ataaaataga ttttgtagat aagttattag
    16561 ttttttatgc tcaggaaaaa tatccgaaaa ttttagaagc ctttaaaaaa caagaattaa
    16621 aaattcaaaa aagaaactaa ctttaaagtt agttttagca agtatacaaa aataaatgat
    16681 tataagttat gtgagagcat cttcaacaaa ctaaaattta gaaagacaat tggataagtt
    16741 aaagacgttt ggcgtagaga aaatatttag aaaaaacaat cagggaaatc gacctgtatt
    16801 ccaagaaacg cttaatttta taagtatgag agatcgattt gttgtagaat cgattaatcg
    16861 tttaggacgt aattacaatg aaattataag gtatttaaag gaaaaagatc ttcagttaat
    16921 gattgccagt ttacctatga tgaatgaagt tattggtaat catttatcag gtaagtttat
    16981 gaaagattta attattcaaa tcttagcaat ggtttcagaa caagaaagaa atgagtatta
    17041 ccagacaagc aatgtataga atcaaacgtg acataacatt atccattatc ttcatgaatt
    17101 gattttcaat acaactgaga gcctctcaca gcgtctgtca atcaagttag atacacaaaa
    17161 caaagtccat caccaaaaat aagtttactc ggaataatta cgtgttcttg ttataatata
    17221 agtatagttg agggaagagg tgcttctcct cctgaagaga ctatttaaca atatctttga
    17281 tgagttgtat taaggctttt aacagattaa ttatttcttt taaaagcttt atctttaaac
    17341 tttgaacaaa aaatcaaatg ttcccccccc atctcttgta aaggagatgg gggaactaga
    17401 ttataagttg ttttcaaaat acaatataac gttatatctg aattttctaa aactttaatt
    17461 ttttgtaata gaaccagatt aaataatcca gttgaattca cttaatgttt gctttacttt
    17521 tttatacttt tctggagtga ttttaaccgt attattctta atcgatttca aaatatagca
    17581 tttactatgc ttatcgaata ttatattttt aatacttttt aaaggaataa gtaatgacct
    17641 acttactaaa ataaatccat aagaatagag ttttttttct aaatatttta aggagccatt
    17701 ataagaaact gtttctttgt catccaaagt gataattatt tttctaccgc aacattctgc
    17761 tgttgtaatt ttatcaattt ctaaaaaata taaagatttc ccctttttaa tggcgatttt
    17821 tctgttttta agattgttaa gatcgaattt ttttctgcat ctatttttga aatgaagtaa
    17881 gcacttctcc aatttaatag gctctactgg ttgtattaaa tagtcaaaag gatgagcttc
    17941 aaaactttta tgtgcgtgtt tggaatcaga agatagaaaa actatttgaa tatgtttatg
    18001 tatagaattg atattattgg ctatatctat aaacttgttg ttatttgtat ttatttttaa
    18061 aaatattaag tctatatctt tcttatctag ggtatttttg gcttcaatat attcactaaa
    18121 tgtaccttta catgaaacaa atgagaagta agatagattt acttttaaat cctctctagt
    18181 acttgcatta tcgtctataa taatagcatt tatttttttc ataaaatcaa ttttcccatt
    18241 cctttatcaa taaaaaatta aaaccaacct tacttcatta atatatcaca attatttttt
    18301 taaatcatta ttattaaatg aactttaaaa tttttttaaa ttgatagatt gtaagattat
    18361 tttgtaaagt atatctgcta gacttcaagt aattgttgcc aataaattgc cttcgatgaa
    18421 gttatcttaa taaaagctgg aaagaacaaa atattaaggt ttcaatactc tccaaaatac
    18481 aataactaaa gacactatat atgttttacg gttcataaaa aatccgtagt tcttttcaaa
    18541 actacggatt ttcgccatgc cataatatta gtatcatgtt aatcaataaa aaaactaaag
    18601 taagtatcac ttaaagttat ttttactgat tttacaacat tccccttttt atgaacaaca
    18661 agtaaataca aattggaaag aattcatatg gcaatcgtgt gacacagttg ggattactcc
    18721 tgactttttc ttagctccta agacttcatt caattcatct tcttgaacct cttctaataa
    18781 atttgctact tcaatgtcct tcataacttt agaattttcc atgtttgtta cctcctaaat
    18841 ttaatatttg ttacaagttt aatatcacat gatatttaca aagtgtaaaa ttgtataaac
    18901 cacttattta tataattaaa atttatattt agagtgataa agtggttttc tatatgaata
    18961 aaataaaaat ttgaaactta caattttgtt agttttaggt ttttccgttt ctgctgcaaa
    19021 atttatcttg tagtatgagg ttagattacc aatattagaa gtaaagcgaa attgtagcaa
    19081 gctagttatt tttataacac tgtaaaagag gaatgttcat acacatcaaa actaatttca
    19141 aacgtcgaaa agatatgtta aagcaaattt atataatgcg ttatatgaat tatgatagtt
    19201 aataatagga gatgatatta actatgaaca acattaaagt tgaacaattt agaggatttt
    19261 caaattttat tttaaaaaaa tactctaaac aagaacttaa cacattaatt gattggaact
    19321 acttaagatc tattattcta gatatttgtg gaaaatcatt gattgtttta attaatgaaa
    19381 aaagattaaa caaaaaactc aatggaaata ctcctgaaga acgctataaa tattttgatg
    19441 aagaattatg tgaaaaaggg attatatatg aagagttaaa taaaagttat ccatcaataa
    19501 taaatgattt agagcaaact ttaaactcat atttttcgtt tttgaaagaa atcgaaaata
    19561 aattcaatca agaaaaaaag aaacttttag aagccaattt aataaaaact gaaaaagaaa
    19621 cgatttgtca tatcagtatt ttaggagatt tacatggagg taaagcggtg actaaagtaa
    19681 ccactgataa atctcaatta ttatataaac ctaggtcatt agaaaatgat agtttctttt
    19741 tagaattctt agaatttatg tacagttttc aaaaaaatga aatatcaaca tactataagt
    19801 ataaattcat agattataaa gaccacggtt ggatggaata tatagaaaag caacctacct
    19861 ctaaaaataa aataaatatg tattacaaaa gattgggata tttattgtct ataggatatt
    19921 tattaaatat aagtgattta catttcgaaa atatactgtg ttccagtaat tttccaatat
    19981 taattgattt agaaactata tttcatacgt ccatatatga atcaaaattt cgtaatttag
    20041 ctacaaagaa tatagaagat aaagctgcta attctgtatt cgctaccgga atgttaccga
    20101 tatccaaaaa agacaaaaaa tacggtggag atataagtgg aatattaggt ggagtattta
    20161 ataaacacga aagaactata agtaatccta atagagatga tataaaattc gaaaagagat
    20221 tagtaagagt taaaagaaat gatcatatcc cattttatat ggaaaatgat aaaaaaagga
    20281 gattttctcc cgaagtattt atagaagata ttcaagaagg ctttaaatat ggttacgaat
    20341 tatttcttaa caatagaaaa gaaatactac attatataaa gaaaacgtca tcagaagtag
    20401 aagtgagaat tttaccaaga agtacaattg agtactcagt attaatacaa gctgctaaat
    20461 cacctcttta tgcaaataag cgaaagagct tgtttaacaa actagaagag tacggtgaaa
    20521 atttattaag tgataagtta ataaattcag aaataaaaca aatagaaact ctttcagtac
    20581 cctattttta tactaaggtc caaagtgttt cggtaaaaga tattaaaaat aatacggtac
    20641 atcacttatt gaaaaaccca ctcaatgtat ttttagaaaa aacgcaaaga tattctttga
    20701 aagatttgtt gtttcaatgt aaactaataa aattttcatt agaaagtcaa aataaattat
    20761 ttattgatgg taatggattt ataaattatg aatatgaaat agtaaattca gacaatattg
    20821 acgatgcaat cgacaattta gtaagcatta taattaataa tgcagtcata gatgaaaaag
    20881 atggttctgt aaattggatg aatttaggca tatcaaaaga agaagaaata atatttgaaa
    20941 gcttgtcaga tgacttatat aaaggattgt caggaatagg aatagcttta ttaaaatatt
    21001 atgaaattaa caaaaactta aaagatatga gtagactaaa aaaaatacta agcagtattt
    21061 attcttctat attaagtaat ataaatacta attctagtaa agaaaaggat ttatcttttt
    21121 ttaatggtga aataggtaaa atcgcatttt tatataaata ccagattgaa tttaaagaaa
    21181 attgcgacag cagtaaaaat tatatgaaac atattttagg gatcatttta tctagtgaat
    21241 ttgaaatgaa tgacattata gccggattac caggaattat ttcatattta tataatcaag
    21301 aaatattttc taaagaactt gtaataatgg gagatagact attaaaagac ttagacaata
    21361 atccaactat ggctagctac gctcacggta aaagtggggt aatggtttca ttattatatt
    21421 tatatgattt aactaaagac aaaaagtatc tagttaaatt ccatcaggaa tggaaaaaag
    21481 aaaacacatt aaaattggaa ataggatgga aagatgtaag acaaaatgaa gaaacctact
    21541 ctgtatcatg gtgtaacgga gttacaggac agttaataag tagactagtt gctttagaaa
    21601 ttcatgataa agtaaaaata tttgatgctg taaataaaaa gttaatgcaa aaagaaattg
    21661 aagaattact ttatttattg aaagaagaag gattagaaca aaataatttt tgcctatgtc
    21721 atggcgtcat gggaaattta ctggttttaa attactatca aaaaaaattt gaaaatacaa
    21781 acattcattt agccaataaa atagacagtc atttttattc agtagctaat tttggtttaa
    21841 ataaaggatg gatatgtggc ttaggaaata acttttactc ttttagcatt atgacaggaa
    21901 tatcaggtat tttatatgct tttttaaagt ataaaactaa ggatactgaa ttaggtatat
    21961 tgttaccaaa catttagttt ggaagaaggt gatgacaatt gaaaatcgca ttacaaaata
    22021 gtgaccaaga ctgtctatta gcgtgttatt caatgatttt gagttatttt ggtaaaaatg
    22081 tatctataaa tagtctttac aaaagagaga tgataccacc tgatggtcta tcaatatctt
    22141 atttgaaaga attaaatatt aagtacgaac ttaatatgaa agtatataga attaaagata
    22201 aagaaaaaac attccgagta ataagtaaaa taaagaaacc aataattgtt cattgggatt
    22261 taaatcattt tgtcatagta aaaaacgtta aaaaaaaaca tatagaaata gtcaacccag
    22321 agataggaaa agtaaaaatt tcaaaagaga tgtttttgga acatttttca aatgttctat
    22381 taatgtttga tcctaagagc gattttacaa aagataaaga aaaaattgag ttctttgacg
    22441 atttaaaaag tgttttaatg aataaaaaca taattctttt ttcattttca gtgatgttag
    22501 ctcaaattgt agctctaatt ttttcaatag ttgttagaga tataataaat caaaaatata
    22561 catacctaat atcattatca atgctattaa tgatgattat tattcaaata ttttctttag
    22621 tttttaagca aaaagctcaa attaaagaga ataaaatata tgaaaaaatc atttcctata
    22681 acatgtttga aggattattt aacaagccct tattatactt tagaaatagc acaataggta
    22741 ctttgatgga aaagataaat ataaagacta ctataaggga caacatactg cttaaaatat
    22801 tgccatcatt cttaaacttc ttttccgtta cggtattgtt tatatatttg ttaactgtat
    22861 cactgctatt atcattatta cttttaggta tgtccattat atatttgtta atcagtgtgt
    22921 ttatatatat aaagaaaaat caattgaata ttgagtatat gcagagaact atacaattta
    22981 gttctttagc tcaagaatca ttaagtcaaa ttgatcaaat taaggcccaa gctcaagaat
    23041 catcaacaat aaataactgg aaagaaaaaa gttggaatat agttaactct tataattcaa
    23101 ttttgaaaat tgaaggatta tcatatactt ttaatcaaat tttcaattac agtagcataa
    23161 tacttttaat gatttttggt attcatctta caaaatacgg aaatataacc atagcagatt
    23221 taatcttatt tcaatccggt atgtctatat ttagttcatc tgtttcacaa ctacaagaca
    23281 ttacgtttga aatatcaaaa attaaagtgt ccggcgagaa aatcaatgac ttatttttaa
    23341 aaaataatac taaaagaaaa gtaatcgagc agaaatctaa taatgcttta tcacttaaga
    23401 atgttacttt tggttttgat gaaaaagccc ctatattgaa aaacattact ttccaagtaa
    23461 aaaaaggtga aaaagtagct atagtaggag actccggatc aggtaaaagt actatgttaa
    23521 atgttctgtt aggtctctat acatgtgatg gtgaagtagt ttacggttat agagatttta
    23581 ggaaaataac aggggtcgtc ttacagaata tgacgttaag taaacaatct atttataata
    23641 atttggtgga tgaaggaaat gatagcaata tgcaaaaatt aaaccaaata ctatacgatg
    23701 ttaatattat aaacttgata aattctttac ctaataaaat atattctagt gtatttcaaa
    23761 atggaaaaaa tctatctggt ggtcaaattc aaaggctatt aattgctaaa tctctattta
    23821 ataaaaaatt aattttttgg gatgaagctt ttagcagttt ggacaattac aatcgtataa
    23881 atatatatag aaatgttttg aaaaatagtc aatatagcga taaaactata gtactcataa
    23941 gtcaccatct agatgtttta tcatatgtcg acaaagtaat gtttattgaa aacggaaacg
    24001 ctttttttgg aacacataat gaattaatta aaaataataa aaattataga agattcttag
    24061 atactgccaa tactaataat taaggagatt caattatgat taacaatatt gtacaaaccc
    24121 aaaatttaac aaaaaagttt tcagatagtt attcagtaga caatctatca ctaaatattg
    24181 gttcgaaaga aatatatgga tttttaggtc caaatggtgc tggtaaaagt actacaatga
    24241 aaatgttact aggtctcatg caaccaacta aaggtaatat taaaatattc aatcaagata
    24301 tttcaaaaaa tagagatgag atattaatgc atgtaggggc attaattgaa gaaccttctt
    24361 attataaaaa tttaactggt ttagaaaatt tgcaagttat tcaaagatta ctaaacttac
    24421 cttctaaaaa tgttaaagaa gctctgaaaa ttgtacgttt aactgaacac aaggataaat
    24481 tagtcaaaaa ttattcatta ggtatgaaac aaaggttagg tattgcttta gctatagtaa
    24541 aatttccaaa actattgata ttagatgaac ctactaacgg cttagatcct tctggtatac
    24601 aagaaattag agaattaata aaatcttttc caaaaactta tggaatgact gtacttatat
    24661 ctagtcattt attatctgaa attgaacata tggctaatac agtaggtatc atcaatagag
    24721 ggaaactatt gtttgaagga aagttaacag aattagaaga acagaacaaa atattgataa
    24781 atactaacaa taacagtgag agtataaact tgcttcaatc aaaaggatat aatctagaaa
    24841 ataatgaaaa acctctccta ttagatacaa ctcaaaaaga tatatctaca gccgttaaat
    24901 tgttagttaa taataagttc gaaatttacc aagtacaatc agttcagaaa agtttagaag
    24961 aaaatttata gaaataacta atgatggaaa ggaatattta taaatgttaa aagctataaa
    25021 tttagaattt ttcaaaatgc ggagaagaaa atttatcctt ccaatactac tgattacctt
    25081 tgttggtata ttgtggtttt gtgctatagc aattaaagag ttaaatatta ctgatacaaa
    25141 gtatggtatt tatatgctca tttctaatat tctaactatc gacagcatga tttatccaat
    25201 attaataggt attttatgct caagacttgc agatatagaa catcaaggaa aaacctttca
    25261 gttattaaat actagtaaac aaagtgtttt caatttgttt actagtaaag ttggtgtttc
    25321 gcttattatt ttatttgtaa ttgacattat acaattaacg accatcttac taattgctaa
    25381 ttcacataat atcagtttga aactagaaat catttcaaaa ttcatgctaa gttttataat
    25441 tgctagtttc ttcttaatat taattcatat ggcactttct ttcttttttg aaaaacaatc
    25501 agttagcatt gtatcagcat tagtaggaag ttttttagga ttagtaacag gagggatgtt
    25561 gccttcatat attaaaatat ttttgccttg gcaatattat tcattactaa atccagttca
    25621 taaaaagatg gttcacaaag gatatgaata ttcaaataat gactattatt ttatttacat
    25681 ttttatttct attctagtaa tagtaattct tttctttatt attaaagcct taataaaaag
    25741 gagggattta aattgatttc tttattaagc atagaattac gcaaactaca aaataattat
    25801 attttaatct tcttattagt ttttaatata ttaagcgtat ctataggaag tatgatattt
    25861 tattttaatc aaagcgcttt tcctaattca aataatagag atttaatatt gtgggggcaa
    25921 gaaactttat atacttcaca acttttcttt cccatactga taggtgtttt atgttcaata
    25981 agttggcaat ttgaggagtc taataataat tggatgagaa tgaaaactat acctttaaaa
    26041 gaaagtaaga tagttttatc aaaattttta tctcttttct tacttacttt actaaatcaa
    26101 attatatttt ttgtattatt ttgtatctca gcctcaatag taaatgtatc cttggaagga
    26161 ttacttaaat ttctatactg ggactttata ggttggatag gtacagcatc tattgttgct
    26221 atacaattat atttgtcagt tgcgactaga aatttcactt tctcaatttt aatatcaact
    26281 attggtggtg tactaggtct tctaacattg tttattagca attttatttt taaaatattt
    26341 ccatattcac aaattacagt tggtgtgaga gccagatctt tgatgaactt cactttttca
    26401 gaaatgttac tttttcttat aataaatgta gcttatataa cagttttttt gacacttact
    26461 actttaaagc ttaaaaaaag agagggttaa tttaaaatga aaagaaaaga ctacttattt
    26521 tttgtaattg cacttttacc tttaattagt ttgttattac agttaatgaa aatttcactt
    26581 atccataatt atcaaagttt tttctctata gttaatatca tctgcatact ttttactatt
    26641 gcttattcaa ttattttagt tattaatagc aagaaaaaga ataatttgca gaaaacaatt
    26701 cttattttgt ctattatcta tatattaact ttaattttta tctcttttgg agtaataatt
    26761 aatatgttta attaaaataa ttttaatagc aaaatactat caaaaatttt cccacataaa
    26821 aagtcacgat aaatttatcg tgacttttta attgctattc atttttacgg atactatgcc
    26881 agttcaataa cctttttttt ctaaaaactc atttaaaaca ttatcaacaa tcgctttaat
    26941 agatgtatct tgatctaatg ccatttgact taaacgtttt tttaaatttg tatccacacg
    27001 catcgtagta cttttagaaa taggtttata attttcagta tatttaactg acgaagtatc
    27061 tatatcatct aaaaatcctg ccattatttt cactcacttt caatcacttg tattctatct
    27121 accaattcta tataaacttt attaaacatg tgtattactt ttttatcatg catatcttta
    27181 tttcttatac cctcagcacc aaatttttta attctttctc tttgataaat ttgattttca
    27241 aatagagctt gtgaaaatgc agttttagac atatttaata ttttctcatc cacttttcca
    27301 cttcgtttaa tcaaaactgg gacagctcca atcaattcaa aaggcaaatt cgattcattt
    27361 tttctatctc ttaaaaagtt tacaaaagac aagctacttt cataagctga ttgttgtgtt
    27421 tgaaatacca taagaatata atcgcttgca tatacagcat tattagtaaa atcagagtta
    27481 atagtcggtg gtacatcaat aaaaatatgg tcaaaatcat acatttccct aatcttttct
    27541 actacatttt ttaaaatata tcttttcttc aaaatatctg ttttagaaat tatatcagac
    27601 aaattagcta atgaagagtc agctggtaac aatgataatt tagacgataa ccgaatcata
    27661 ctattttcta aatttccggt tctaagcata tctataaacg attcattttc ctctggcgct
    27721 tcgacatatg tccgtttcat aatttgcgta gcgttcccct gcggatcaaa atctataagt
    27781 aatactttct taccatactg ctctgatgct atataagaaa gtattgttgc tactgttgtt
    27841 ttacctactc cgcctttaaa atttccaact gttattacac tcaaataaaa accccctatg
    27901 ttacatgtaa catgttacta atgtttattc tttctgtcta atttaaatca atttgctata
    27961 aatcaaaaaa gaattactta tatatcctat gttacatgta acatgttact aatgtttatt
    28021 ctttctgtct agtttaaatc aatttgctat aaattaaaaa agaattactt atatatccta
    28081 tgttacatgt aacatgttac taatgtttat tctttctgtc tagtttaaat caatttgcta
    28141 taaattaaaa aagaattact tatatatccc atgttacatg taacatgtta cttaagggaa
    28201 agttacaata ttctttgtta atttttctta aatttgttac tatgaactta acgttcatta
    28261 atatatttaa aaagcactta atcgttgggg cgattaagcg ctttaggtaa taaacactat
    28321 actaacattc actactaaac attaagaaaa gtgctatcta tatacattta tatattctgg
    28381 atgctcaaat ttcaatccat tttgtagaat caattgtata atataagtaa tatcaattca
    28441 agaaagatat cttaatttaa ttagtattgt gatttattac ctcaacccta aatttatgtg
    28501 aagaggtatt tactatgact aaacaacgat ttacaaaact atataaattc ttattcgaag
    28561 attccacatt taacaaacta tcaataaaag ctaaattgct ttatgcatta ttaaccgaac
    28621 gtcaaaactt atctaagtta agtgccaaac aacatggtat tcaatcacaa tttattgatg
    28681 ataacggacg tttattctca atttatacta ataaagaact tatgaatata attaatatat
    28741 ctgaacctac tgttattaac ctaaaaaagc aactcattgc atttggctta ttagaagaaa
    28801 tacgccttgg aaaaaataaa ccgaatcgct tatatcctaa aaaaccttat gatgaatatt
    28861 tctatgttca tgatgttgat gaattttatc ggttaccaca ttcattattt tctaatccta
    28921 aatataagaa tcttaaagct gagacaattg tcgcttacgc tgtttaccta agccgttatg
    28981 aatatagtgt atacaaaaat catttttcgg ataaaagtgg tgaaatatat tgccattttt
    29041 ctaatgagaa aatggctgaa ttcttaggtg ttagcacacg aaaagtagag cgtatcaaaa
    29101 aagaacttgt agtttctggt ttgatgatta acaaacgtgc aacatttgga aaagcaaata
    29161 atttatatat taacctccct aaaccttttc atataaagga actaaaaaat tgtcgggttc
    29221 ggaacttaaa aattgtcggt actggaacta aaaaattgtc gggttcggaa cttaaaaatt
    29281 gtcgcactag taatattgat attagtaata ctgatgttag tgatactgat attagtgata
    29341 cgaatgattt gaatgataca tatgaaataa ataaaaatac taattatcat tcgaatcata
    29401 caaatcatca acaaactgaa tttaataatg atgctttaaa atttcaagtc cttgaagaat
    29461 tacctacgca aatcaagatt tatttaagta attttgaaat taaagacatc cgttttatta
    29521 aaagtgtgtt actcaaaggg aaaaagtcat ttaataatgt acatgatacc tattaccgtt
    29581 tagaagacgt cgaatttgaa cttgtgagtg ttttaaaacg ttttaaagcc atgttactac
    29641 aaaaaaatga aaccgttgaa actatgcaag gctatttaat gcaatcaatt aaagctgaac
    29701 ttgaagaaat acatgtatta aatatgcgtc gtcaaaacat acctcattac aatatcttta
    29761 atcaataact caaataatct tacagcaatc aaaacaacat caaaatttga aattaagtca
    29821 acataaaatg tacgttaacc tatgtgtagg acttaagcaa aatataaaca ttttaaacta
    29881 gaagagggca aagataggac cttattttta caagaaaggc gttgaataat tgctaaccaa
    29941 tttctatgcg aatttttaaa tttgcatgta actgggcaat gtcttaaaaa atcgacactg
    30001 gatttgctca aattttatgt tgtgaaatta aaatatattt atttggctct catttgcttt
    30061 ttaagagttt atgtaattgt ttaggcataa aactatataa aatactctta attctttaaa
    30121 atgccccttt aaaattaaaa ataaagacat tctaattttt aaaatatact tagataaaaa
    30181 taaaaagcta actcaaaatg a
//
