LOCUS       NC_005011              20654 bp    DNA     circular CON 27-MAY-2024
DEFINITION  Staphylococcus aureus plasmid pMW2, complete sequence.
ACCESSION   NC_005011
VERSION     NC_005011.1
DBLINK      BioProject: PRJNA224116
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1
  AUTHORS   Baba,T., Takeuchi,F., Kuroda,M., Yuzawa,H., Aoki,K., Oguchi,A.,
            Nagai,Y., Iwama,N., Asano,K., Naimi,T., Kuroda,H., Cui,L.,
            Yamamoto,K. and Hiramatsu,K.
  TITLE     Genome and virulence determinants of high virulence
            community-acquired MRSA
  JOURNAL   Lancet 359 (9320), 1819-1827 (2002)
   PUBMED   12044378
REFERENCE   2  (bases 1 to 20654)
  AUTHORS   Director-General, Biotechnology Center, Aoki,K., Oguchi,A.,
            Nagai,Y., Asano,K., Iwama,N., Baba,T., Kuroda,M., Hiramatsu,K. and
            Kikuchi,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2002) Director-General, Biotechnology Center,
            National Institute of Technology and Evaluation, Biotechnology
            Center; 2Chome 49-10 Nishihara, Shibuya-ku, Tokyo 151-0066, Japan
            (E-mail:bio@nite.go.jp, URL:http://www.bio.nite.go.jp/,
            Tel:81-3-3481-1933, Fax:81-3-3481-8424)
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009945035.1-RS_2024_05_27
            Annotation Date                   :: 05/27/2024 02:47:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 25
            CDSs (total)                      :: 25
            Genes (coding)                    :: 21
            CDSs (with protein)               :: 21
            Genes (RNA)                       :: 0
            tRNAs                             :: 0
            ncRNAs                            :: 0
            Pseudo Genes (total)              :: 4
            CDSs (without protein)            :: 4
            Pseudo Genes (ambiguous residues) :: 0 of 4
            Pseudo Genes (frameshifted)       :: 3 of 4
            Pseudo Genes (incomplete)         :: 1 of 4
            Pseudo Genes (internal stop)      :: 2 of 4
            Pseudo Genes (multiple problems)  :: 1 of 4
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP004832.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..20654
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:1280"
                     /plasmid="pMW2"
     gene            228..904
                     /locus_tag="HXF13_RS00005"
                     /pseudo=""
     CDS             228..904
                     /locus_tag="HXF13_RS00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /name="replication initiator protein A"
     gene            <915..1197
                     /locus_tag="HXF13_RS00130"
                     /pseudo=""
     CDS             <915..1197
                     /locus_tag="HXF13_RS00130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199895.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            2407..3024
                     /gene="cadD"
                     /locus_tag="HXF13_RS00010"
                     /old_locus_tag="MWP003"
     ARG             2408..3021
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="99.51"
                     /coverage="100.0"
     gene            3043..3390
                     /locus_tag="HXF13_RS00015"
                     /old_locus_tag="MWP004"
     CDS             3043..3390
                     /locus_tag="HXF13_RS00015"
                     /old_locus_tag="MWP004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000119691.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNQEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            3559..3651
                     /locus_tag="HXF13_RS00020"
                     /old_locus_tag="MWP005"
     CDS             3559..3651
                     /locus_tag="HXF13_RS00020"
                     /old_locus_tag="MWP005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001791613.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            3863..4837
                     /locus_tag="HXF13_RS00025"
                     /old_locus_tag="MWP006"
     CDS             3863..4837
                     /locus_tag="HXF13_RS00025"
                     /old_locus_tag="MWP006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4062 domain-containing protein"
                     /protein_id="WP_000072390.1"
                     /translation="MSNTKIKYQIFISSTYLDLIEERQAVVEAVLNSNNIPAGMELFNS
                     SSKSQWEIITQWINESDAVILLLGSSYGTIDSEENISYTEMEYNFAKSLGKPIYVFEMN
                     KASTESAEKSKKLDEFKTKVKENRLISPNINDISELKSKVSQTLMQSVPSEIKENSGWI
                     RVQDCGKNVKKLKKLDAIQRDLDTYDFLKEELYKIFMYVKTFYFQHTPFDDSYIEDIEN
                     YLLNYENNPHKSFMKIKVYDYKNFLKHLKNILILIKQGKKPLAQAGHFKLSFYEEDLKL
                     LQKNYKATLVDIKGLNKHFYKECDRCLKAYNIFIEGINKHLYE"
                     /name="DUF4062 domain-containing protein"
     gene            complement(4957..5772)
                     /locus_tag="HXF13_RS00030"
                     /old_locus_tag="MWP007"
     CDS             complement(4957..5772)
                     /locus_tag="HXF13_RS00030"
                     /old_locus_tag="MWP007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019467708.1"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WP_000164958.1"
                     /translation="MTKNQNFIETKEYKRFAEFCDACIKYQYIGICYGQPGVGKTLSSR
                     YYTNWDTIEKQVNHRGWEDLASKTTDDILSVDKIFYNAPAEKQTKLRNDLYSITAIIDL
                     GQKLHVVNKYGHEHSKHYSDMFKYIDLIIVDEIDRLKVQHLEQLRAIYDEHNLAMIFIG
                     MPGIEKKLSRYPQLYSRIGFAHEFDNLSKDETHHILEYKWQDLGFDLKLEDFTDYEAIT
                     TIIKITKGNFRLIHRLFAQIDRIMDINGLDKISTEVVETARDSLVIGIR"
                     /name="AAA family ATPase"
     gene            complement(5765..7208)
                     /locus_tag="HXF13_RS00035"
                     /pseudo=""
     CDS             complement(5765..7208)
                     /locus_tag="HXF13_RS00035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790716.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Mu transposase C-terminal domain-containing
                     protein"
                     /name="Mu transposase C-terminal domain-containing protein"
     gene            complement(7180..7773)
                     /locus_tag="HXF13_RS00040"
                     /old_locus_tag="MWP010"
     CDS             complement(7180..7773)
                     /locus_tag="HXF13_RS00040"
                     /old_locus_tag="MWP010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690636.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690638.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNQKDLNLLKTLYDNGTPI
                     KTIAEQWHVSRTTIYRYLNKLEDKEDEKQGEVSN"
                     /name="recombinase family protein"
     gene            complement(8037..8417)
                     /gene="blaI"
                     /locus_tag="HXF13_RS00045"
                     /old_locus_tag="MWP011"
     ARG             complement(8041..8417)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            complement(8407..10164)
                     /gene="blaR1"
                     /locus_tag="HXF13_RS00050"
                     /old_locus_tag="MWP012"
     ARG             complement(8411..10164)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.56"
                     /coverage="100.0"
     gene            10271..11116
                     /gene="blaZ"
                     /locus_tag="HXF13_RS00055"
                     /old_locus_tag="MWP013"
     ARG             10272..11113
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            11485..12018
                     /locus_tag="HXF13_RS00060"
                     /old_locus_tag="MWP014"
     CDS             11485..12018
                     /locus_tag="HXF13_RS00060"
                     /old_locus_tag="MWP014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001823239.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001823239.1"
                     /translation="MIVGYARVSSNDQNLERQLENLKTFCAEKIFTEKQSGKSIENRPV
                     LQEALNFLRMGDRFVVESIDCLGRNYDEVVGNPLLDKFMKDLIIQILAMVSEQERNESK
                     RRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRIIYHRVVEMLEEGQSISKIAKEVNIT
                     RQTIYRIKNDNDLI"
                     /name="recombinase family protein"
     gene            12432..12725
                     /locus_tag="HXF13_RS00065"
                     /old_locus_tag="MWP015"
     CDS             12432..12725
                     /locus_tag="HXF13_RS00065"
                     /old_locus_tag="MWP015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_000726503.1"
                     /translation="MKKKFVSSCITSTILFGTLLGVTYKAEAATVHVAGGVWSHGIGKH
                     YVWSYYSHNKRNHGSTAVGKYSSFSGVARPGVQSKASAPKAWGGNKTFYSLH"
                     /name="lactococcin 972 family bacteriocin"
     gene            12800..14734
                     /locus_tag="HXF13_RS00070"
                     /old_locus_tag="MWP016"
     CDS             12800..14734
                     /locus_tag="HXF13_RS00070"
                     /old_locus_tag="MWP016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001670421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="WP_000713728.1"
                     /translation="MKKFKLFLDFSTLLLISGLLFLFFFKENEEIIPESSNILTISNWD
                     KSNSKSKVLDVIESGAKNQNIQIIKSVKDFDNKKEFFVFNSKRNNSDFIRNKTSLLTPS
                     DLLNREIKGKYYIIGEHFNVEELTSELKKAGLTSEVEYINRNILFFELVIDNDLLVPFI
                     FLGVLYLLYFLYDRGYNLKFYAIQKLHGFSTTRIIFHNIHIKIIYWLVLTAIFFIANIL
                     IIHIANLELDFLMFIRKFIVLLFVFACITTLLWLISYSLLLKLSIPLILKGKKGYKFSI
                     FMGTFTKCIMVLILSFLLAQNLNAYTKLKNIYDSEKIWQKLDNYYTLEISPNIRNSEEK
                     QILETNIYNLIKKSEQLGGLLLKNNNIANPDKNNYIPENGNVFFINNNFLNFYKNINHD
                     FKMIDNHSDKINVFIPPRLQYQKSEIQKNHQGWIDFQKQQNKKVDVQVLSKNVSVFSFD
                     RTTNLKFGYLDSPIVMLLTLDDLTGDFYLAAVSQGGYLFKDLDTLKQLLKDNHLEEEIS
                     GITNYKDSVLNELNETKTKMIITIVTIIINVFILLIATVFETIQYFSWNKKQLLLRKIH
                     GYSLFSSNVRYLTISILLSIMLAYTTHILFGSKILLFIIMSIAIIQHLLQIAYIKYLEK
                     YFKDLMREI"
                     /name="bacteriocin-associated integral membrane family
                     protein"
     gene            14738..15049
                     /locus_tag="HXF13_RS00075"
                     /old_locus_tag="MWP017"
     CDS             14738..15049
                     /locus_tag="HXF13_RS00075"
                     /old_locus_tag="MWP017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YxeA family protein"
                     /protein_id="WP_000831610.1"
                     /translation="MKRTLIIVTIVLLIIILSLLLVRNEHLDRFNPLLKEKVSYAKVPK
                     DTQDYRNITVYSKNGEKKSYKLDFLGYDPTKEYVKVNHKGKYVRSIEYITKDIPSFLK"
                     /name="YxeA family protein"
     gene            15061..15687
                     /locus_tag="HXF13_RS00080"
                     /old_locus_tag="MWP018"
     CDS             15061..15687
                     /locus_tag="HXF13_RS00080"
                     /old_locus_tag="MWP018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000593103.1"
                     /translation="MIKLENVFVKKGNKNILDGCNFNFEKGKSYALVGESGAGKSTLLN
                     IIAGFEDVSQGSIYIEDKLLKKKVDFYRYTLGYLFQNFALLENQTISQNLDLALKFKKN
                     KKDNMNLKKEVLKKVGLDLDIKRIVSSLSGGEQQRVALARLILKDPKIILADEPTGSLD
                     TKNGKIVIDLLLKLLDENKTMIVVTHDLELAKRFDVIVNISELRS"
                     /name="ABC transporter ATP-binding protein"
     gene            15925..16554
                     /gene="mobV"
                     /locus_tag="HXF13_RS00135"
                     /pseudo=""
     CDS             15925..16554
                     /gene="mobV"
                     /locus_tag="HXF13_RS00135"
                     /inference="COORDINATES: protein motif:HMM:NF013258.4"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MobV family relaxase"
                     /name="mobV"
     gene            16648..17193
                     /locus_tag="HXF13_RS00095"
                     /old_locus_tag="MWP021"
     CDS             16648..17193
                     /locus_tag="HXF13_RS00095"
                     /old_locus_tag="MWP021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001805533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000273005.1"
                     /translation="MYEIKTKNVGGWFHKEKQETGNIVITKTDFEKYTKQIKAAQMILD
                     DYECIKSGKSLKKAEKQNESLVNELTSVHMENEKLVEEFNDLAQRYNYLLSENEKKDKE
                     LNYTLKLFNQVFKIIKSMMKEERYHTLINHIDNHLDNSKIREVMTIDNNDEQFFKKKYQ
                     AQEREIIFKEDREDGYTL"
                     /name="hypothetical protein"
     gene            complement(17235..17519)
                     /locus_tag="HXF13_RS00100"
                     /old_locus_tag="MWP022"
     CDS             complement(17235..17519)
                     /locus_tag="HXF13_RS00100"
                     /old_locus_tag="MWP022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001793642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001793642.1"
                     /translation="MKTFIHNKLLYYQCQTIKGVQLFKTLLLCGKNTPFMWQKHSFYVA
                     KTLLLCGKNTPLGIEIPCCSRAEQAPKKVFKKIYKNILKSSRGATYFSS"
                     /name="hypothetical protein"
     gene            17577..18437
                     /locus_tag="HXF13_RS00105"
                     /old_locus_tag="MWP023"
     CDS             17577..18437
                     /locus_tag="HXF13_RS00105"
                     /old_locus_tag="MWP023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_000145511.1"
                     /translation="MTGETVVYKNEMNLVPLRRFTATEINLFFAMCNKLKEQDTNTLRL
                     SFDELKKLSNYSPETRNINRFANDLDNVYKKMLNLTIRYEDDDVIERFVLFNHYRIHKR
                     EQYLEISTSSNLKHILNSITNNFTKFELKEMTRLKSTYSKNMFRLLKQYKHTGYLKIHI
                     DDFKNRLDIPKSYRMTDINKNVFKPIIIELGSIFNNLTINKIKAKKGRKIEWIEFTFDA
                     EKRIHNKRQPQMSKIDKSRQYVRREKTPKWLEERSYEKQPQKDYDPQLEKEREDFLKQL
                     ELNWE"
                     /name="replication initiation protein"
     gene            18524..18865
                     /locus_tag="HXF13_RS00110"
                     /old_locus_tag="MWP024"
     CDS             18524..18865
                     /locus_tag="HXF13_RS00110"
                     /old_locus_tag="MWP024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761340.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000761341.1"
                     /translation="MKLAEAIKEQRELKGWSQEELANILKVSRQSVSKWESAKNYPSLD
                     ILIAMSDLFGISLEHLIKGDARFKKVILEGNYRESNRVPSIVDFLYDFWWLFFPVAGFL
                     VWAIHSFMG"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(19104..19175)
                     /locus_tag="HXF13_RS00115"
     CDS             complement(19104..19175)
                     /locus_tag="HXF13_RS00115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_106873653.1"
                     /translation="MNEILVHIMTTAISGCLVTLFGY"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            19324..19509
                     /locus_tag="HXF13_RS00120"
                     /old_locus_tag="MWP025"
     CDS             19324..19509
                     /locus_tag="HXF13_RS00120"
                     /old_locus_tag="MWP025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000466619.1"
                     /translation="MFGDQRQEATKYVIKEGYQDIYFLNKNGEWYYFEVRSVWRGKHII
                     RVKDGLLGWRKEIVTE"
                     /name="hypothetical protein"
     gene            complement(19728..20471)
                     /locus_tag="HXF13_RS00125"
                     /old_locus_tag="MWP027"
     CDS             complement(19728..20471)
                     /locus_tag="HXF13_RS00125"
                     /old_locus_tag="MWP027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_000843757.1"
                     /translation="MKSVKRLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESATEDKQKKESDNINFESKSDAQIVEILKNQINTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNAR
                     QNVDAQEKTYTTSPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAQREDVSANPND
                     NDSDIEEKSEETEAKKGFWSRLFGN"
                     /name="DUF536 domain-containing protein"
     ARG             10272..11116
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     BGC             7432..17725
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          1255..1402
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="81.333"
                     /coverage="100.0"
                     /evalue="2.96e-25"
     Typing          17578..18437
                     /name="rep_cluster_2214"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(19729..20471)
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          15926..16200
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="94.565"
                     /coverage="100.0"
                     /evalue="4.71e-46"
ORIGIN
        1 attcaaagtg ctataataac cttaatataa caaaaacccc aactactggt aatagtcggg
       61 gtttggtaat aaaacgttta gaaactgttt atttatataa ttttcgatac ttagattata
      121 taatgaataa tatcttagtg caagcaccta gattattaaa taaacacaaa aaatgtaagc
      181 gttttattac ctcttaccaa actaaaattc ggaaagaggt ttttattatg tcaattaaac
      241 tttacaacat aaatgaggaa tacagagaaa agttttatca aataccgaaa gtatttttta
      301 caaatcctaa atatatcaag ttatccaatg atgcaaaaat ggcatggggt attcttagag
      361 atcgtttaga tttatcaatt aaaaatggtt gggttgattc taaaacaggt aatatttatt
      421 tttattacaa aaatgaaaac ccacaaaata tattaaattg taaaaaagat aaagtaatta
      481 aaataaagaa agaacttaat tgaagccgaa ttactactac aagaaagaca aggtttaaat
      541 aagacaaata aactttattt agttaaacca gaagtaacag aagatgatat ttataaaatt
      601 caaaagcaag aaaacactgt tgagagcagc aatggcaagg aagtcggaaa aaccgacttc
      661 aagaagtcga taaaacagaa tctaatgata ctgaacttag ctatactgaa tctaacaata
      721 ctgaaataaa tgatatgaat gacttgaatg atatagagtc cgaaaatgaa attagtaatc
      781 attcaagtca atgcaaggtt atttaatgca aacaatttta actgaatttg aagaaacaca
      841 tgcactttat atgcgccgta aaaacatgaa acaatataat atctttaatc aatcattcaa
      901 atgattttat aacaatcaaa gatacatcaa aatatttcgt taaatcatct gactttttaa
      961 ctgatagcga tgaaaaaatc aagaaattgt cagtgatcta gaaaaagatt tgtatcgaaa
     1021 acgtatgtta agttatggtg gattgcttaa ataaaaacat aaaattttaa acttagacga
     1081 tgctgaagat ggcaatttaa ttaatacaag tgatgaagat aaaatagcaa atgaagaaga
     1141 aaaggcacat tcgattacgg caattttgaa aagcaaaatt attatttaag gcattagtga
     1201 taactgatgt ctttttttat tacttttttg taaaaaaagt gctgtcttat ttttgtgaca
     1261 aatgctgtat gtagtgtcac aaaagtgtga cacttgagct ttttatgacc ccacacaaaa
     1321 acattttcga agccttgaaa tatctggctt tgccagatcc cccattcatt gatggggaca
     1381 aatttccctt atgctcttac ggagatttta gagttaaatt aaaatttcta agtttttgat
     1441 aagaaaagcc ctgcaggaat ttagaagaac gtggggaagt tttaaagaat tttatgctaa
     1501 tttttaattt gcatgtaaat gggcagtgtc taaaaaatag ttattgtttt tgctcaaatt
     1561 tttgtttttg aaaatagcat atatttattt ggctcatatt tgcgttttaa aagcgtatat
     1621 aagttttaga taaaactata tgaatcaccc ctaaatcttt aaaatgccct cttaaaattc
     1681 aaaataaggg cataaaaaat aaaagccccc cccagataaa gtgaggtagc tttttctttc
     1741 gacgccgtat cgtcgatgta attcaaaaaa gttatgggct ataaatctac atcacttttt
     1801 caagaatgta gtagcaatat tcaacgcaaa ttaattttta taactgctcg gaatatctca
     1861 agccgtttct ttaattttga aataaaaaaa tcgacgaagg tcgattacgt ttttgcacat
     1921 gtcgatttat ccgacgtata agtgcgccct tacgggattt aactagatta taacgacgaa
     1981 ttttagacct gtaaagcaat aacaattagg tctaccaggt agataaagtg tacaaagtag
     2041 aaccgaaaaa gttatttatt ttgaagattt ttcgtagata taatttgcta ataaacttcc
     2101 taaaactgaa taaagaaaaa tagttaaact catgtaatca ctccataatt ctgaagtgtc
     2161 tccatgtcta cgcatagaca cgcatttatg ccgagaaaat ttattgtgcg ttgagaagaa
     2221 cccttaacta aacttgcaga cgaatgtcgg catagcgtga gctattaagc cgaccattcg
     2281 acaagttttg ggattgttaa gggttccgag gctcaacgtc aataaagcaa ttggaataaa
     2341 gcacctatga ttatttaaaa atataagtta taatacattc aaaaatattt ttgaatgagg
     2401 tgtattatga ttcaaacggt tgttgctgct gctgttcttt atattgctac agcagttgat
     2461 ttattagtaa ttttattaat attttttgct agagcaaaga ctagaaaaga atatagaaat
     2521 atttatgttg gtcaatattt agggtctatt attttaatat tagttagttt gtttttagct
     2581 tttgtattaa attatgttcc agaaaagtgg atattaggtt tattgggttt aataccaatt
     2641 tatcttggaa ttaaagtggc tatttatgat gattgtgaag gagaaaagag agctaaaaaa
     2701 gaattgaatg aaaaaggatt gtctaaatta gttggtacgg ttgcaattgt tacgatagca
     2761 agttgtggcg ccgataatat tggtttattt gttccttatt ttgtgacatt aagtgttact
     2821 aatttattac ttactctgtt tgtcttttta attttaattt tcttcttggt gtttactgca
     2881 caaaaattag ctaatatccc aggaattgga gaaattgttg agaaatttag tcgttggatt
     2941 atggctatca tttatatagc tttaggttta tttattatta ttgaaaatga cactattcaa
     3001 acaattttag gatttatatt ttaatttagg gtgtgatttt atatgagtta tgaaaatact
     3061 tgtgatgtga tctgtgtaca tgaggataaa gttaacaatg ctttaagttt tttagaagat
     3121 gataaatcta agaaattact taacatttta gaaaaaattt gtgatgagaa gaaattgaaa
     3181 atcatattat ctttgattaa agaagatgag ttgtgtgttt gtgatatttc tttgatattg
     3241 aaaatgagtg ttgcttcaac ttcacatcat ttaaggcttt tatataaaaa tgaggtactt
     3301 gatttttata aagatggaaa gatggcatat tattttatta aagacgatga aataagagag
     3361 tttttctcta aaaatcagga gggtttttga aacgagtgaa acgagtttct tcttgtcttg
     3421 atactataaa aaacaaagtt atataacata agacgactta tcggaagtta tctatcatcg
     3481 tatattcgga gatgatataa tatacaggtc gcctatctct caggcgtcaa ttcagacgca
     3541 gagaggaggt gcattacttt gctaatcatt ttcgttcaca tcatagcacc agtcatcagt
     3601 ggctgtgctg ttgcgtatta tacttattgg cttagtaaac gcaacaaata attaataggc
     3661 gactttataa gccagcatcg aaaaaatccc cacactattg cagtagtgtg gggattggtg
     3721 cattaattgt taatcatttt cgttatctag attataacac tggttagtag aggaatgcaa
     3781 aaagataata ttttaagtag tctttttgga tattatcata tgatatattt atgtaaattg
     3841 attttttatt aaaggagcat atatgagtaa tactaaaatt aaatatcaaa tttttatttc
     3901 atcaacttat ttagatttaa tagaagagcg tcaagcagta gtagaagcag ttttaaacag
     3961 taataatatt ccagcaggta tggaactttt taactcaagt agtaaaagcc aatgggaaat
     4021 aataacacaa tggatcaatg aatcagatgc agtgatatta ttgttaggtt ctagttatgg
     4081 aacaattgat agtgaagaaa atattagcta tacagaaatg gagtacaatt ttgctaaatc
     4141 tttaggtaaa cctatatatg tttttgagat gaataaagca tctaccgaat ccgcggaaaa
     4201 gtctaaaaaa ttagatgagt ttaagacaaa agttaaagaa aatagactaa ttagtccaaa
     4261 tattaatgat atttcggaat taaaaagtaa agtatctcag actttaatgc aaagtgtacc
     4321 tagtgaaatt aaagaaaata gtggatggat aagagtacag gattgtggta aaaatgtaaa
     4381 aaaattaaaa aaattggatg ctatacaaag agatttagat acatatgatt ttttgaaaga
     4441 agaactttat aaaatattca tgtatgtaaa aactttttat ttccagcaca caccatttga
     4501 tgatagttat attgaagata tagaaaacta cctgctaaat tatgaaaata atccacataa
     4561 atcattcatg aaaataaaag tttatgatta taaaaacttt ttaaaacatt taaaaaacat
     4621 attgatttta attaaacaag gaaaaaagcc attagctcaa gccggtcatt ttaaattaag
     4681 cttttacgaa gaggatttaa aattgttaca aaaaaattat aaggctacgc tagtcgatat
     4741 taaaggattg aataaacatt tttataagga atgtgatagg tgcttaaaag catataatat
     4801 ttttattgag ggtataaata aacatttata tgaatgatat aagtacaccc taatcataca
     4861 tatataattg ttgtcacttt actcgatata tgagaatgac tttacctaat aaatgagaaa
     4921 agcaacgcac tatattaaaa tgcgttgctt tttctattat cgaataccta taactaaact
     4981 atctctagct gtttctacaa cttctgtact tattttatct aaaccattta tatccataat
     5041 tctgtctatc tgcgcaaata aacgatgaat cagcctaaaa ttcccttttg taattttaat
     5101 aatcgtcgtt attgcctcat aatcagtaaa gtcttcgagt tttaaatcaa atcctaagtc
     5161 ttgccactta tattctaata tatgatgcgt ctcatcttta cttagattat caaattcatg
     5221 cgcaaaacct atacgcgaat atagttgagg ataacgagat agttttttct ctatacccgg
     5281 cataccaata aatatcattg ctaaattatg ttcatcataa atagctctta attgctctaa
     5341 atgttgcact ttaaggcgat caatctcatc tactataatt aaatcaatat atttaaacat
     5401 atcactataa tgtttactat gttcatgtcc atacttattt acaacatgta atttttgacc
     5461 caaatcaatg attgcagtaa tactatataa atcattcctt aatttagttt gtttttctgc
     5521 tggtgcatta taaaatattt tatccaccga tagtatgtca tcggtcgttt tactagctaa
     5581 atcttcccaa cctctatggt taacttgttt ttcaatagta tcccaatttg tgtaatacct
     5641 agacgataaa gtttttccga caccaggttg accataacat ataccaatat actgatattt
     5701 aatacaagca tcacaaaatt cagcaaagcg tttatactct ttcgtttcaa tgaaattttg
     5761 atttttagtc attacgatat ctctttaatt ttttgacgtt tttagtcgtt tcttgaggtg
     5821 aataaccaca atttttttct tccttaatta attccgtggt acttggacta gcaatatttt
     5881 gttttaagtg ttttcttctc tgactacgag cgtgctgtat gtcttttata tctatggagt
     5941 aatcagctat ttctggacat atagcagtac aaagaaattc atctctataa aacacacgta
     6001 tttcagccat atcatttggg ttataacgaa tcagtacata ttcacctaca taagcttcta
     6061 gattagtatt actgtatcga aaaccttgaa aatgaatgcc atctgaatga acttttctag
     6121 atttaggtat ttccaacaat aataaatcaa gttgttctaa gctacttggc atattaggga
     6181 aaaagtgatt actattccaa tgactgatag gcgtggtatg aatagtacta tgttcttttt
     6241 gattataatc ttcaattaaa aagtaacgta atttttcttc aaaattgtga aaatttatta
     6301 gattactagg agtatcatta ttgtttatat atccaggcag ttgttctaag aaagtttgat
     6361 taactgtctg aaagaatcgt tctatttttc cacgaccacg aggaacacca actttcgaaa
     6421 acatcaagtt aattttcaaa tcaatagcga cttgttccat atgatgtgaa gtaaagtcac
     6481 ttccatgatc tgtgtagaat ttttcgggta taccacacac tggccaattg gtatcatttt
     6541 tattccatat tgcttggtgt agtgttaatg ctgtgttttg agcattgggg ggcatcaaaa
     6601 cttaagaaat agcctgcaat tgcacgacta tagtcatcca taataatagt tagccatggt
     6661 ctattgatat tacctttttg gtctaatata aagatatcta gcaaagtatg gtctgcttgc
     6721 catatttcat tgggtctcga ggattctcta atttgtatta aatcgtactt attttgatag
     6781 tatttttcac cctgatgaga gaaatcaata acagacttag gcatcgcttt aataacacta
     6841 taaatttgtt tataacttgg tatatcaaaa ttattttctt tacagtaatt agtgattttc
     6901 ctatgaattg tggctatact atttctttta ttcataagcg caaggcgttc aatttcatca
     6961 attatctttg gttctatttt acgtgttcct ttatcagctc ttgtcgcata gattagtcct
     7021 ttaagtcctt gttctttata tgacttattc cacctataaa gggtgcttaa cgcaatccct
     7081 ttacttttag aaatacttga taaagattgt tcgcctagga taaaaggttt tataatattg
     7141 tacttttgag tagctttttt acgtttggct tcagaaaaat tagttagata cttctccttg
     7201 tttttcatct tccttgtcct ccaatttatt gaggtaacga taaattgttg tacgtgaaac
     7261 atgccactgt tctgcaattg tcttaattgg cgtgccatta tcataaaggg tcttaagtaa
     7321 gtttaaatct ttttgattta atttttctgg tctgcctcca tatcggcctc tagcacgtgc
     7381 tgcaattcgg ccagctgaag aacgctctaa aattaaatta cgttcaaatt ctgcaaatgc
     7441 tgcgaataaa tgaaataata attgtccagt tgaacttgat ttatccattg ttatattttc
     7501 ttctaaacta tggaaactta cacctcgttc gttaagctca ttaactaatg tgattaaatc
     7561 ctccatatta cgtcccaatc tatctaatct ccaaacaaca atcgtatctc ctgacctcgc
     7621 aaattcaatt gctttatcta aaccaggtct tttacttttt gaaccactca tatggtcatt
     7681 aaatatcttt tcacaaccat atgtatttaa tcgatcctcc tgtaaattta aattttgtaa
     7741 tccagttgaa actcttgcat aacctatttt caaaatacaa acctcctata tacatcttca
     7801 gtgtaccata acttaattac aaggtctttt atgaacatag attttttgtt gggtttttga
     7861 acacataatc ctatgtaatt cttacttatt tagacataaa agaagagtgt acagaaaatg
     7921 gttattttct gtacactctc atctttaata atatatttta aatgtcatta acaaaactaa
     7981 tttaataaga gtcaagcata gtttacatat gtattatgtt tgaaacatac ctctaattac
     8041 tttttactaa tatcatttaa aatatctcgc aattcttcaa tttctttgtt atttaattct
     8101 tcatttttcg caaaattcaa cactaaactt ttcatatccc ctccatacag tttattaaga
     8161 aaggttttag cagttttcat tttaatatcg tcttctttaa tatttgatga gtaaaaataa
     8221 atattttctg atttgtatcg ttttataatc tcttttttat atagtcttgt gattaatgtt
     8281 ctaatcgttt tatcactaac ttctttatat ttttgaattt caactacaat ttcattagct
     8341 gatactgatt ttttatccca tattatattc ataacatccc attcagccat agatatttca
     8401 acttgcttat tggccattta aaacacccat tccttttaat attttttcac ttattaattc
     8461 agcatttttc ccagacgggt ttccatctga taaatgtgta gcaaaataat acttatcatg
     8521 atttgtaatt acgtaaccta caaaccaccc attattatac ttcccgttta ctatacctgt
     8581 acctgttttc ccatacagtt catacttttc atttttctta atcaataatg aagaagataa
     8641 ttgattcttt gcttttttac taaaatggtt attttgttcc atcatatttt taaaaactat
     8701 tacttgttca agattagata ttttcaaact atcttccatc caatagcttt tataacttcc
     8761 caaattttca ttaccataat ttaattgctt gagttgagcc gcagtatagt tctttggtat
     8821 ttgattacta atacgttcga agtaccaatt aactgaattt tgcattgctg tatttaaatc
     8881 ttgttcctta ttccaagact cgaaaagata atgtttatga ttccatgaca tacgtgaatt
     8941 tttatcactt ataatatgac ggtcaagtcc aaacagtgct aaataaattt tgtaagttga
     9001 atcaggagaa tatctttttc tactttcttt ttcattataa atatagtatt tgtctttctt
     9061 catgctgtac ataacgaaag atccactatt tgaaccaaaa tttttacttt catctaaaat
     9121 ttggtaatcg ctttgtaagg gctttttata attataatca gttaaggatt gccccattaa
     9181 aaactggctt tgaattatca tgataaaaaa agtaaaaata caaataaaaa ttagaattaa
     9241 ttttgactgc tttttcagat cggcttcttt tatattaatt aatctatttt tgagtaatga
     9301 ttttttacca ttaaatgaat ggcttaatat atttttgttg aaaaatgagg tttttaatac
     9361 ggagtccata atagattccg cataagtttt aaattcattt ttgttaatat tattaaggac
     9421 aaatctatcg gcttctactt cattgtcatg aattatcttt ctttttacaa tatgtactaa
     9481 tggattgtaa ctcataataa tagagaagat attaaagata attaaatgta aagtatctct
     9541 atttttagca tgagcatatt catgcagtat tatatatttt agtcttttat caattacact
     9601 tttaaaatat gaactaggaa tcaaaataat atatttccca taccaaaaag ttattggaga
     9661 ttgaatagcc tctgcttttc gaatcacaat atttttttta tattgatggt tgaaaagtat
     9721 cgtatctatt ttattttttt cattttcgtt tagataaagt gactgtttct ttaaatattt
     9781 aagatataat aaggctttca aaaatttaaa acttaaaata ataactaaaa ctatccaaat
     9841 aactgtgcag atattatcaa ttgaatccca attaaactta tggatatctg ttgcgaactc
     9901 ttgaacaggt ttggtggtaa ttatgttatg gttcaagtcg tgtgacttac tttcaactgt
     9961 gggcgcttga ttattcacat tattaaattt tataaaagag aatttaattg ggataaaagg
    10021 aattaatcca gcaagcacag ttagatacca aactttataa tttaaactat aattaaaata
    10081 gcgttttaat atgtacctaa aaaatactaa caatagaaat ataaaacaaa agcttactac
    10141 actcattatt agtaatttag ccattttgac accttctttc aaatatttat aataaacaat
    10201 tgacatcaat attacaattg taatattatt gttttgtaaa aattacaact gtaatatcgg
    10261 agggtttatt ttgaaaaagt taatattttt aattgtaatg gctttagttt taagtgcatg
    10321 taattcaaac agttcacatg ccaaagagtt aaatgattta gaaaaaaaat ataatgctca
    10381 tattggtgtt tatgctttag atactaaaag tggtaaggaa gtaaaattta attcagataa
    10441 gagatttgcc tatgcttcga cttcaaaagc gataaatagt gctattttgt tagaacaagt
    10501 accttataat aagttaaata aaaaagtaca tattaacaaa gatgatatag ttgcttattc
    10561 tcctatttta gaaaaatatg taggaaaaga catcacttta aaagaactta ttgaggcttc
    10621 aatgacatat agtgataata cagcaaacaa taaaattata aaagaaatcg gtggaatcaa
    10681 aaaagttaaa caacgtctaa aagaactagg agataaagta acaaatccag ttagatatga
    10741 gatagaatta aattactatt cgccaaagag caaaaaagat acttcaacgc ctgctgcttt
    10801 cggcaagact ttaaataaac ttatcgcaaa tggaaaatta agcaaaaaaa ataaaaattt
    10861 cttacttgat ttaatgttta ataataaaaa cggagacact ttaattaaag atggtgttcc
    10921 aaaagactat aaggttgctg ataaaagtgg tcaagcaata acatatgctt ctagaaatga
    10981 tgttgctttt gtttatccta agggccaatc tgaacctatt gttttagtca tttttacgaa
    11041 taaagacaat aaaagtgata agccaaatga taagttgata agtgaaaccg ccaagagtgt
    11101 aatgaaggaa ttttaatatt ctaaatgcat aataaatact gataacatct tatagtttgt
    11161 attatatttt ctattatcgt tgacatgtat aattttgata tcaaaacctg attttccctt
    11221 tattattttc gagatttatt ttcttaattc tctttaacaa actagaaata ttgtatatac
    11281 aaaaaatcat aaataataga tgaatagttt aattataggt gttcatcaat cgaaaaagca
    11341 acgtatctta tttaaagtgc gttgcttttt tctcatttat aaggttaaat aattctcata
    11401 tatcaagcaa agtgacataa ttgttgaatt tatagtaact gaaacgtatg attagggtgt
    11461 atattaatta tgagatggaa atcaatgatt gttggctatg cgagagtatc atcgaacgat
    11521 caaaatttag aaagacaact tgaaaattta aagacgtttt gtgctgaaaa aatatttaca
    11581 gaaaaacagt ctgggaaatc tattgaaaat agaccagtac ttcaagaagc acttaacttt
    11641 ttgaggatgg gagatcggtt tgtagtagaa tccattgatt gtttaggtcg taattatgat
    11701 gaagtggttg gcaatccatt actggataag tttatgaaag atttaattat tcaaatatta
    11761 gcaatggttt cagaacaaga gagaaatgaa agtaaacgtc gacaagcgca aggaattcaa
    11821 gttgcgaagg aaaaaggcgt atataaaggg cgccccttac tttattcacc aaatgctaaa
    11881 gatccacaga aacgtattat ttatcatcgc gttgtagaaa tgttagaaga aggccaatca
    11941 attagtaaaa ttgcgaaaga agtaaatata acaaggcaga cgatttacag aattaaaaac
    12001 gataatgatt tgatttaata aactttgttt caatgcaact gagagcttct cacagcgtct
    12061 caaaacagat gattataatc tattatgagt ttttaataat aagacaagaa aagagagcgt
    12121 aaatatgctc tctctttttc tcattaacga acgtttataa cgcaatcatg atgagagtat
    12181 taatacagtt aattatttga aatactttag tttatataat gttgaattat aggtagtgaa
    12241 attgtattta ttatacattg tcatatcgtt gtttaatgat agttaattta aggataatag
    12301 aattaatatt atatatagat gaacaaaaca agcaacagag cagaaaaaac acttttagat
    12361 tatttttact cattctctat tttatttatt tttgctataa taaataaaga atattaaatg
    12421 gaggtgtttt tatgaaaaag aaatttgttt ctagttgtat tactagtaca atcttattcg
    12481 gcactttatt aggtgtaact tataaagctg aagctgcaac agtacatgta gctggtggtg
    12541 tttggagcca tggtattgga aaacattacg tatggtctta ttatagtcac aataaaagaa
    12601 atcatggttc aacagcagta gggaaatatt catcttttag tggtgttgct cgacctggtg
    12661 ttcaatctaa ggcatctgct ccaaaggctt ggggtggaaa caaaacattt tatagtcttc
    12721 actaattaca tatattaatt aaggagaata gacagaatta agtaaactta attctgtcta
    12781 ttctcttgaa agaggcaata tgaaaaaatt caaattattt ttagatttta gtactttatt
    12841 attaatttca gggctattat ttttattttt cttcaaagaa aatgaagaaa ttatacctga
    12901 aagttccaat attttaacaa tctctaattg ggataaatct aacagtaaat caaaagtgtt
    12961 agatgtcatt gaatcaggcg ccaaaaatca aaatatacaa ataattaaat ccgttaaaga
    13021 ttttgataat aaaaaagaat tttttgtttt caactcaaaa cgaaataatt ctgactttat
    13081 acgtaataaa acatcacttt taactccatc agatttatta aacagagaga taaaaggaaa
    13141 gtattatatt attggtgaac atttcaatgt agaagagctt acgagtgaat taaaaaaagc
    13201 tggtttaaca tctgaagttg aatacataaa tagaaacata ttattttttg aattagtcat
    13261 agataatgat ttattagtgc ctttcatatt cttaggcgta ttatatcttt tgtacttctt
    13321 atatgacaga ggatataatt tgaaatttta tgctattcaa aagctacatg gcttttcaac
    13381 tacacgcatt atttttcata atattcatat aaaaatcatt tattggctag tacttaccgc
    13441 tattttcttt attgctaata tattaatcat tcatatagcc aatttagaat tggatttctt
    13501 aatgtttatt cgtaaattta tcgtgttgct ttttgttttt gcttgtatta ctacattgct
    13561 gtggctgatt tcgtatagtc ttcttttgaa gttaagtatt ccattaatct taaaagggaa
    13621 aaaaggatat aagttttcaa tatttatggg taccttcacc aaatgtatca tggtgctaat
    13681 actatctttt ttactggcac aaaatttaaa tgcttatacg aagttaaaga atatatatga
    13741 ctctgaaaaa atctggcaaa agttagataa ttactataca ttagagattt ctcctaatat
    13801 tagaaattca gaagaaaaac aaattttaga aactaatata tacaatttaa ttaagaaaag
    13861 cgaacaactt ggtggattgc ttttaaagaa taataatata gccaatcccg ataaaaacaa
    13921 ttacattcct gaaaatggca atgtcttttt tatcaataac aattttctga atttctataa
    13981 aaatataaat catgatttta aaatgattga caatcattcg gataaaataa acgtgtttat
    14041 tcctccaagg ttacaatatc aaaaatctga aattcaaaaa aatcaccaag gatggattga
    14101 ctttcaaaag caacaaaaca aaaaagtaga tgtgcaagta ctgtcaaaaa acgtatctgt
    14161 tttttctttt gatcgcacaa ctaatttgaa atttgggtat ctagattctc caatagtaat
    14221 gttgttgaca cttgacgatt taacaggaga tttttattta gctgctgttt ctcaaggtgg
    14281 atatctattt aaagatttag atacacttaa acagttgctt aaagataatc acctagaaga
    14341 agaaattagc ggtataacta attacaagga ttctgtgtta aatgaattaa atgaaacgaa
    14401 aacaaaaatg ataataacaa tagttactat tattattaac gttttcattc ttttgatagc
    14461 tactgtattt gaaacaattc aatattttag ctggaataaa aagcaactat tattaagaaa
    14521 aattcatggt tattcattat tcagcagtaa tgtacgttat ttaacaattt ctatcttact
    14581 ttctattatg ttagcttaca ctacgcatat tttatttggt tcaaagatat tactattcat
    14641 aataatgtct attgctatta ttcaacattt acttcaaatt gcttatatta aatatcttga
    14701 aaaatacttt aaagatttaa tgagggagat ttaaacaatg aaaagaactt taattattgt
    14761 aacaattgta ctattaatca tcatacttag tctgttattg gttagaaatg agcatttaga
    14821 tcgttttaac ccactgttaa aagaaaaagt atcttatgcc aaagttccaa aagataccca
    14881 ggactataga aatataactg tatactctaa aaatggagaa aaaaagagtt ataaattgga
    14941 ttttttaggt tatgatccta caaaagaata tgtgaaagta aatcataaag ggaaatatgt
    15001 gcgttcgata gaatacatta caaaagatat tcctagcttt ttaaaatgag gtgaccgata
    15061 gtgataaaac ttgaaaatgt ttttgtaaaa aaaggtaata aaaacatttt agacggatgt
    15121 aactttaatt ttgaaaaagg aaaatcatat gctttagttg gagaaagtgg cgctggaaaa
    15181 tctactttac ttaacataat cgctgggttc gaagatgtat cacaaggaag catatatatt
    15241 gaagataagt tactaaaaaa gaaagtcgat ttttatagat atacgttagg gtatttgttt
    15301 caaaattttg ctttacttga aaatcaaaca atcagtcaaa atttagattt agccctaaag
    15361 ttcaaaaaga ataaaaaaga taatatgaac ttaaagaaag aagtattaaa aaaggtcggc
    15421 ctagatttag atatcaagag aattgttagt tctctaagcg gtggtgaaca acaaagagta
    15481 gcattggcaa gattaatatt aaaagatccg aaaatcattt tagctgatga acctactggg
    15541 tcactagata cgaaaaatgg aaaaatagtt attgatttat tattgaagct acttgatgaa
    15601 aataaaacta tgattgtcgt aacgcatgat ttagagcttg cgaaacgatt tgatgtcata
    15661 gtcaatattt ctgagcttag aagttaagaa atattgatag gtatagccat acatagagaa
    15721 aaaacaatat gaaatatgat tagtcattac ttttgagttt tttaatttaa ggactggatt
    15781 ttccagtcct tttttatgat gacaaaaaac aagcctcgca gagcacacgt ttttaatgac
    15841 ttatttggtt tttaataagt ctagtatgtt aaaacttttc tgtgtttagg tgttataatc
    15901 atatgcagtg gaagttgatt tattatgtct tattcaatta ttcgagttgt taaagtgaaa
    15961 tcaaaaacaa atacaagagg tattcaaaga catattcaaa gagaaaataa aaattatgaa
    16021 aatatagata ttgatttaag taagtcatat ttaaactatg atttagtcaa tgatactaag
    16081 tttgatttta ataaaaaaat tgatgagaaa atcgaaaaaa attataaagg gaaacgcaaa
    16141 attagaacag atgccattaa acatattgat ggattaatta catcagataa tgtgtttttt
    16201 aatcaattat ctgaagaaga gacaaaatag ttttttaagc atgctaaagc gttcttggaa
    16261 gaagaatacg gtaaagaaaa tcttttatat gcgacagtac atatggatga gataacacca
    16321 catatgcatt atggcgtagt tcctattact aaagatggac gtttaagtgc gaaagaagtt
    16381 gtaggtaata aaaaagcatt aaccgaattc caagatagat tcaatacgta tattaataag
    16441 caaggctatg atttaaaacg aggaatttct agacaactta caaaagaaaa acatgatcaa
    16501 gttagccgtt ataaacaaaa aacagaatat cataaacaaa tgcatatgcg ctagaagcaa
    16561 atagaggatt atttaaagca agaaaatgat aaattgatac aaaactacca aaaatcatta
    16621 gatacgctta aaaagcttct gagtgtcatg tatgaaatta aaactaaaaa tgtaggtgga
    16681 tggtttcata aagagaagca agaaacaggc aatattgtaa ttactaaaac tgattttgaa
    16741 aaatacacta aacaaattaa agcagcacag atgatattag atgattatga atgtattaaa
    16801 agtgggaagt cattaaaaaa agcagagaaa caaaatgaaa gtttagttaa tgaattgact
    16861 agtgtccata tggaaaatga aaagctggtt gaagaattta atgatttagc acaacgttat
    16921 aattatttgt tgtcagagaa tgaaaagaaa gataaagaac taaattatac gcttaagtta
    16981 ttcaatcaag tttttaaaat cattaaaagt atgatgaaag aagagcgtta tcatacacta
    17041 ataaatcata ttgataatca tttagacaat tctaaaatac gtgaagtaat gacgatagat
    17101 aacaatgatg aacagttctt taagaagaaa tatcaagcac aagaacgaga aatcattttt
    17161 aaagaagata gagaagatgg ttatacatta taaaaataga tatttaaatg catttgtttg
    17221 aggttaatta ttttttagga tgaaaaatag gtagcccccc tcgaactttt taatatattt
    17281 ttataaatct ttttaaaaac ctttttaggg gcttgttcag ccctagagca acaagggatt
    17341 tcaatgccta aaggagtgtt tttgccacat aaaaggagtg tttttgccac ataaaaggag
    17401 tgtttttgcc acataaaagg agtgtttttg ccacataaaa ggagtgtttt aaaaagttgt
    17461 actcctttta tggtttgaca ttgataataa agtagtttat tgtgaataaa agttttcaaa
    17521 tgggagtgta tattcaaacg atactccttt aggttcgtaa taaagggggc tgtatcatga
    17581 caggagagac agttgtatat aaaaatgaaa tgaatttagt tccattaagg cgatttacag
    17641 ctactgaaat taatttattt tttgcgatgt gtaataaatt aaaagagcaa gatactaata
    17701 cattacgttt gtcttttgat gaattaaaaa aattaagtaa ttatagtcca gaaacacgta
    17761 atattaatag atttgctaat gatttagata atgtgtataa aaagatgttg aatttaacca
    17821 ttagatatga agatgatgat gtaatagaaa gattcgtttt attcaatcat tatagaatcc
    17881 ataagcgaga acaatatcta gaaatatcaa cttcttcaaa tttaaaacac atattgaatt
    17941 caattactaa taattttaca aaatttgaat taaaagaaat gactaggctt aaatctacat
    18001 attctaaaaa tatgtttaga ttacttaaac aatacaaaca tacaggctat ttaaaaattc
    18061 acatcgatga ttttaaaaat cgtttagata tacctaaatc ttatcgtatg actgatatta
    18121 acaaaaatgt ttttaaacct attattattg aattaggttc tatatttaat aatcttacta
    18181 tcaataaaat caaagcgaaa aaagggcgta aaattgaatg gatagagttc acatttgacg
    18241 ctgagaaacg cattcataac aaacgacaac ctcaaatgtc caagatagat aaatcaagac
    18301 aatatgtgag gcgtgaaaag acgcctaaat ggttagaaga acggtcatat gaaaagcaac
    18361 ctcaaaaaga ttacgaccca caattagaga aagaacgaga ggatttttta aaacaacttg
    18421 aactgaattg ggaataacgc aacttttcgt tgcgagttgg ttaactaaaa gtatcgtgac
    18481 ttttcaatta ttttaattat agtttgagtt aaggagtgat tttatgaaat tagctgaagc
    18541 tataaaagaa cagagagaat taaaaggatg gtctcaagag gaattagcca atatattaaa
    18601 ggtttccaga caaagtgttt ctaaatggga aagtgccaaa aactatcctt ccttagatat
    18661 tttgattgct atgagcgatt tattcggaat ctctttagag catttaatta aaggagatgc
    18721 acgttttaaa aaagttattt tagagggaaa ttatagagag agtaacaggg taccttccat
    18781 agttgatttt ctttatgatt tttggtggct tttctttcct gttgccggat ttttagtttg
    18841 ggccattcat tcgttcatgg gttgatttta aaatcaaaat ttaatgcaca tcaggcaata
    18901 tgaaaaagga aagtattttt acgacacctt gaaatgtatt gataagaata gaagagttta
    18961 caaaaggcaa tatgaaatat atactaaaag taacaagaat ttcgtttgta aacgcaccaa
    19021 accccgaact attcgccgta gttcggggtt ttttggtgaa ttggctttaa tcgtctatat
    19081 tattttttat cacgtttatg gagctaataa ccaaataacg taacgagaca accactgatt
    19141 gccgttgtca tgatgtgaac aagaatttca ttcataaatc gcacctcctc tctacgccga
    19201 attgacatct gagagataga cgaccttcac attataacaa atctctcctt ccatgaaata
    19261 acatgaatat taataaatgt tgttatatat taaagataaa taaatataag ggtgggattg
    19321 ataatgtttg gcgatcaaag acaagaagct acaaaatatg tcattaaaga aggttatcaa
    19381 gatatttatt tcctcaacaa aaacggggaa tggtattatt tcgaagtaag aagtgtctgg
    19441 cgtggcaaac atattattag agttaaagat ggtttgttag gttggagaaa agaaatagta
    19501 actgaataaa gatacaaaat acttgccaat gcaaaagaat gaaaacgcgt caaatcaacg
    19561 atgtataaaa gatgcataaa agataatgaa agtaaaaagc cataaatgcc gtcatatagg
    19621 catttatggc tttttgtttg gttaatataa tcgatgatta tcagaagttc aattcacata
    19681 aaaaagcacg gctaatttat gaacttgtcg taccttttta attaaaatta gttaccaaat
    19741 agacgactcc aaaacccctt tttagcttcc gtttcttcac tcttttcttc tatatcacta
    19801 tcattgtcat ttggattagc tgaaacgtct tctctttgtg cttcttcacc ttgtgtactt
    19861 tcgtcgcttt gacttccaga tatatcctta tattgaatct ctgtttcttt agtttcttcc
    19921 tgatctcggt taatatttac aggactagta gtatatgttt tttcttgtgc atcaacgttt
    19981 tgtctagcgt tagtagatgt atcaaaggga taattaaggt gtttttcttt ttctaattga
    20041 ttttctaatt tttgaatctt tttattactc tctaatgcca gaacttgctg attctcaagc
    20101 aattttgatc tttcttgcaa ctcttttctg taaaattcaa ttgttgtttc atgacgactt
    20161 tcttgttttt caatttgatt atttaaagta ttaatctgat ttttaagtat ttctactatt
    20221 tgagcatcgc ttttagattc aaaattaata ttatccgact cttttttttg tttgtcttca
    20281 gtagcacttt caaaaccata tttcttttta ttttcattta ctctttgaat gattttttct
    20341 atatcggtat cttctttaat aaacgaagtg ttttcctgtt ttattgtctc tatattcaat
    20401 ctcttaatat tattaaaaat cgtttgctta ctaaccccta attcttcact caaccttttt
    20461 acacttttca tatcatcaac cctttataaa atgtttataa acccttagta aaatattata
    20521 agcttataac gattaataat aaagtaatcg acaaataaaa atataaattc gccaaccttt
    20581 ttatcaaggg tttgtaaagg gtttatggtg tttatcaaag gtttataaac ctatattttc
    20641 ccttttttaa gttt
//
