LOCUS       NC_005006               8007 bp    DNA     circular CON 27-MAR-2024
DEFINITION  Staphylococcus epidermidis ATCC 12228 plasmid pSE-12228-03, complete
            sequence.
ACCESSION   NC_005006
VERSION     NC_005006.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN02603126
            Assembly: GCF_000007645.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus epidermidis ATCC 12228
  ORGANISM  Staphylococcus epidermidis ATCC 12228
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 8007)
  AUTHORS   Zhang,Y.Q., Ren,S.X., Li,H.L., Wang,Y.X., Fu,G., Yang,J., Qin,Z.Q.,
            Miao,Y.G., Wang,W.Y., Chen,R.S., Shen,Y., Chen,Z., Yuan,Z.H.,
            Zhao,G.P., Qu,D., Danchin,A. and Wen,Y.M.
  TITLE     Genome-based analysis of virulence genes in a non-biofilm-forming
            Staphylococcus epidermidis strain (ATCC 12228)
  JOURNAL   Mol Microbiol 49 (6), 1577-1593 (2003)
   PUBMED   12950922
REFERENCE   2  (bases 1 to 8007)
  AUTHORS   Zhang,Y., Ren,S., Li,H., Fu,G., Lu,L., Lu,G., Jia,J., Tu,Y., Qin,Z.,
            Chen,Z. and Wen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-NOV-2002) Chinese National Human Genome Center at
            Shanghai, 250 Bi Bo Road, Shanghai 201203, China
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000007645.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 00:52:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,440
            CDSs (total)                      :: 2,359
            Genes (coding)                    :: 2,283
            CDSs (with protein)               :: 2,283
            Genes (RNA)                       :: 81
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 76
            CDSs (without protein)            :: 76
            Pseudo Genes (ambiguous residues) :: 0 of 76
            Pseudo Genes (frameshifted)       :: 49 of 76
            Pseudo Genes (incomplete)         :: 40 of 76
            Pseudo Genes (internal stop)      :: 25 of 76
            Pseudo Genes (multiple problems)  :: 28 of 76
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AE015932.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..8007
                     /organism="Staphylococcus epidermidis ATCC 12228"
                     /mol_type="genomic DNA"
                     /strain="ATCC 12228"
                     /db_xref="ATCC:12228"
                     /db_xref="taxon:176280"
                     /plasmid="pSE-12228-03"
     gene            328..3657
                     /locus_tag="SE_RS11855"
                     /old_locus_tag="p301"
                     /old_locus_tag="SE_p301"
     CDS             328..3657
                     /locus_tag="SE_RS11855"
                     /old_locus_tag="p301"
                     /old_locus_tag="SE_p301"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed DNA polymerase"
                     /protein_id="WP_164924958.1"
                     /translation="MKNLQKGVFLFMNKNIFNNKFRQEIDGSVFNIFGTIVIEKRISKV
                     TKAPSLVTFGFAKNLSTTGFINGGHWLPYGGVPCMPPLSSPPYFLDTKQFFVGDGLLKY
                     YISNNITPPFVGDDCSISEKNWKYFKDLFEYNQSFSNRYYINRTIKPDVDVRDYIKRYI
                     NKQSLTLGFDTEWSGDERSALSYQFSTTVDGSDYDIVFYPDHNFSERLKLGHMLYFIVN
                     YLFVGRGFVVKHEGKEHHKNPSYKTCQILLVAHFGGVDFSMLSDYQELLSYLDYSESQK
                     SQMRHIEKLVKTGRNPKTNKNLLQSDLDILAERYKKIKDNPEHSYNLIVSDKHCMYTRS
                     PRIYNFWYRPRKARCMFNIDIRDTMKLAPPGSPLASLGQSLGISKLDTLELDKGDNKPV
                     NHYKSHMDELLQNHPQFFHDYAVRDARISYEWYKMVVSIIGDGLTVSSISAKHLQKNIR
                     EAMESYYKNGVSWSNDVVGFDIEDHKPNYNSVSHTRGLFGDMPDYAYMGGRNEAFTHGL
                     ITGRTYDYDLRSAYPFQMQCMRMIDFDKPPIVFNKGHELSLNDWKHFGQAGFGYVKFEF
                     PENVKYPTIPLKSTKTGLEGTPVFLRTGEGLVSAPDVFAALHVGAKVTVAKQGFMFFDL
                     KRSSEHDHGSFDDIDVDNDFIMHHVGFGVRNMIKIRAKYAKQYGKKSVQAQLMKILVNS
                     TYGKTGQGIHGNTARNILNNETEVIPFSRITDGVIASTTTALVRSVLGLIMNYIDRLGY
                     TVHSVTTDGFISDFPWERMLEIDEYLSGISTVFQKVIKACWGETLDWSTGKGSILEVKH
                     IQDEFFFNVKTRGNISLDVGKPYTNPYTSNVENYDGVFAKAGYKGDNDFKYLTDYDKRF
                     KLLNQIVNRNGALIDYQTDMLSFREVKQSNLKSITKAYDSKEDLEKRLSMDFDKKRMLL
                     PREFSNIKTDVFKSDYGWFPTRPFENMEEYEYNAGIHKLFIGKDHCIKDDLTFTAYQYA
                     LNNGFPKYKRVNEKKLTSDELVEHQQIAKKYDIKQYLVYLLKFPELHPEDDFLRDVEDF
                     SRKDYLDLILKLDGVDALETWKSIKKRTKHTFDLLTALEYDKRLKRFYFNTYYYVLSEE
                     SY"
                     /name="DNA-directed DNA polymerase"
     gene            3686..3979
                     /locus_tag="SE_RS11860"
                     /old_locus_tag="p302"
                     /old_locus_tag="SE_p302"
     CDS             3686..3979
                     /locus_tag="SE_RS11860"
                     /old_locus_tag="p302"
                     /old_locus_tag="SE_p302"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_164924959.1"
                     /translation="MGVEQLKRQLDVVSQLKNNVDDTSVDVMNRELESVVFTVLSLFGH
                     DDENVEINETLNRLQHQSRTDEPTHKNNLAIFDSFKKLENLLTHDERFKEYF"
                     /name="hypothetical protein"
     gene            4215..4859
                     /locus_tag="SE_RS11865"
                     /old_locus_tag="p303"
                     /old_locus_tag="SE_p303"
     CDS             4215..4859
                     /locus_tag="SE_RS11865"
                     /old_locus_tag="p303"
                     /old_locus_tag="SE_p303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002504404.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_011117528.1"
                     /translation="MAKIGYARVSTKEQNLDLQIEYLKSHGVDDGLIFVDKGVSGGVAP
                     EQRDGFKQLLQKARSGDTLIVYKLDRISRKYDDVQTVIKTLKDSGLNFEIGGLPNINTG
                     NKLMDKALTDMLINLLGYVAENERAYIKERQRDGIELAKKQGRFKGKPKKYSPHSKDKY
                     GRYIYNQIVEDLNSGMSYNAVRLKHEVGMSTVHRIAHEIEEDNNGSKYSKK"
                     /name="recombinase family protein"
     gene            4834..5211
                     /locus_tag="SE_RS11870"
                     /old_locus_tag="p304"
                     /old_locus_tag="SE_p304"
     CDS             4834..5211
                     /locus_tag="SE_RS11870"
                     /old_locus_tag="p304"
                     /old_locus_tag="SE_p304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002487432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_164924960.1"
                     /translation="MDQSIVKNKEDYVKDTEQIRHNISTTQERFNKEKNKLANHQHKFD
                     KMQLEFTNDMSMKLLDKVSSGEIDVKDLPNIKSYLFDDIGSLDVSSEVPVSSSDTDETA
                     QSTSSHSDVDHNPFADANRHS"
                     /name="hypothetical protein"
     gene            5519..5968
                     /locus_tag="SE_RS11875"
                     /old_locus_tag="p305"
                     /old_locus_tag="SE_p305"
     CDS             5519..5968
                     /locus_tag="SE_RS11875"
                     /old_locus_tag="p305"
                     /old_locus_tag="SE_p305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002487434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_011117530.1"
                     /translation="MSDVKHKLPETERKTKTIVFRIREDEYDRLKTLSDELRGYKSPNE
                     IARLITLEWLDHKQTFKPKQVFDNETFEVMKDLRILASELRNDIQGIARNFNQYIKLLN
                     TRKLRNELSVDDLKNIDEFRQQFKKTRKNIGDFNRKVGSLSQQSK"
                     /name="hypothetical protein"
     gene            6079..7167
                     /locus_tag="SE_RS12455"
                     /old_locus_tag="p306"
                     /old_locus_tag="SE_p306"
     CDS             6079..7167
                     /locus_tag="SE_RS12455"
                     /old_locus_tag="p306"
                     /old_locus_tag="SE_p306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002487433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="WP_225793071.1"
                     /translation="MAITGDSAFLAKPQMRDVQKQYNKQEGFVQGYSIIDSYSEDEIPK
                     DGKRSTIQLVHEMGLEKARRIYGENYQCLVATQCDGKSGLYHNHLISNAVGNDGKSQRG
                     DMTKWTKLAEISDQVMIDYGYTPLDKNNWRLNKTRKAEARSKGEYVSPNERKARKNGMT
                     LAKDEVREQIQKVIDDETVKSFEDFKQMLNEEYQIGVEDAGTKDGENIKYSFSYTNKKG
                     ETSEKTIKAKTLSKEDYTLSGVKSKIEDKLLETGNFEINENDLTQQQQQMLSNLIVPED
                     DEDELELEFDDESLAFLDQINEEVKEYGREKHSSKATRNNQRVEKQHRDHQRHVENNER
                     STTRTKSSSKRAKDKDAGFELG"
                     /name="relaxase/mobilization nuclease domain-containing
                     protein"
     gene            7247..7684
                     /locus_tag="SE_RS11880"
                     /old_locus_tag="p307"
                     /old_locus_tag="SE_p307"
     CDS             7247..7684
                     /locus_tag="SE_RS11880"
                     /old_locus_tag="p307"
                     /old_locus_tag="SE_p307"
                     /inference="COORDINATES: protein motif:HMM:NF015839.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF334 domain-containing protein"
                     /protein_id="WP_309498284.1"
                     /translation="MQSSDLYDITGAVKKGLTDNLKKATEDVVKETNDFRVKSQNEIKE
                     ATNELISYSRKLKDETEKYKKWYVSAMVGFVAFAVVLLLFTTLADMPFLEHAYQFIATK
                     IEHSKTWYVTGLWYLAYLITPMFWVGVVTGVAYMLHKWYTD"
                     /name="DUF334 domain-containing protein"
     gene            7696..8007
                     /locus_tag="SE_RS11885"
                     /old_locus_tag="p308"
                     /old_locus_tag="SE_p308"
     CDS             7696..8007
                     /locus_tag="SE_RS11885"
                     /old_locus_tag="p308"
                     /old_locus_tag="SE_p308"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_011117533.1"
                     /translation="MLTIKQLADKLGVSKPTITRNKPEHMEFTVIDGVNYIDETLEQQI
                     TQKVLQNKTRYSGDRSTETNDSTLVQQLLQENAFLRAQIEEKDALLKTQAKLLDQQQQ"
                     /name="hypothetical protein"
     Typing          6122..7164
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aatttagtta cggggcaacg gttgaatgaa ttggaaagta gttcagaaga tacagaggtg
       61 gaaaaagaaa cagaaccggt gaagaaaagt ttgtttaaaa gatggttcgg acaaaataaa
      121 tagcacaaat gcgttcgaaa cgcattcgtg ctataataaa taaaaaggtg acttgctctc
      181 aacaagacac cggaaaaaaa gatataatta ataaaacagg gtctgaaact gttttattta
      241 tgtgatattt aaagtatacc atgagtatat tgagaacaca attgtttaat aaatgataaa
      301 aaatagtctt gttgggagca cacctttttg aaaaatttac agaaaggtgt gtttttattt
      361 atgaataaaa acatttttaa taacaaattt agacaagaaa ttgacggatc agtttttaat
      421 attttcggta caattgtcat cgaaaaacga atttcgaaag tgaccaaagc accctctttg
      481 gtcactttcg gatttgcaaa aaacctctca accacgggct tcatcaatgg ggggcattgg
      541 ctaccatatg ggggagtgcc atgtatgccc cccctttcgt ccccgccata ttttttagat
      601 accaaacaat tttttgttgg tgatggttta ttaaaatatt atatttcgaa taacataaca
      661 ccaccttttg ttggtgatga ttgttccatc agtgaaaaaa attggaaata ctttaaagat
      721 ttgtttgagt ataatcaaag ttttagtaat cgttattata ttaatcgtac tattaaacct
      781 gatgttgatg ttcgtgatta tattaaacgt tatatcaaca aacagtcttt aacacttggc
      841 tttgatactg agtggtctgg tgatgaacgt agtgctttaa gttatcaatt ttcaacgact
      901 gttgatggtt ctgactatga tattgtgttt tatcccgacc ataatttttc tgaacgttta
      961 aaattaggtc atatgttgta ttttatcgtt aactacttgt tcgttggtcg tggttttgtt
     1021 gttaaacatg aaggtaaaga acatcataaa aatccctcat ataagacttg tcagattcta
     1081 ttggtagcac atttcggtgg tgtggacttt tcaatgttat ctgactatca agagttgtta
     1141 agttaccttg attacagtga atctcaaaaa tcacaaatgc gtcatattga aaagcttgtt
     1201 aaaactggtc gtaaccctaa aacaaataaa aatttacttc agtctgattt ggatatttta
     1261 gctgaacgtt ataaaaagat taaagacaat ccggaacatt cttacaattt gattgtgagt
     1321 gataagcatt gcatgtatac gcgttcgcct cgtatctata atttttggta tagacctaga
     1381 aaggcacgtt gtatgtttaa cattgatata cgtgacacga tgaagttggc tcctccgggc
     1441 tctcctttgg cttctctggg gcaatcttta ggaatttcga agttagatac ccttgaactc
     1501 gataaaggcg ataataagcc tgtaaatcac tataaaagcc atatggatga attacttcaa
     1561 aatcatcctc aatttttcca tgactacgct gtacgtgacg ctcgtataag ttacgaatgg
     1621 tacaaaatgg ttgtaagtat catcggtgat ggtttaacgg tcagttccat ctctgccaaa
     1681 cacttacaga aaaatattcg tgaggcgatg gaatcgtatt ataaaaatgg tgtttcatgg
     1741 tctaatgacg ttgtggggtt tgatattgaa gatcataagc cgaattacaa cagtgtttct
     1801 catactcgtg gtttattcgg tgatatgcca gattatgcat atatgggtgg tcgtaatgaa
     1861 gcgtttacgc atggtttaat tactggtcgt acttatgact atgatttacg ctctgcgtat
     1921 ccatttcaaa tgcagtgcat gagaatgatt gattttgata aacctccaat cgttttcaac
     1981 aaaggtcatg aactatcttt aaacgattgg aaacactttg gacaagctgg gtttggttat
     2041 gtaaaatttg agtttcccga aaacgtcaaa tatcctacta ttcctttaaa atcaactaaa
     2101 actggtttag aaggcactcc agtcttttta agaactggcg aggggcttgt gtctgcacct
     2161 gatgttttcg cagcacttca tgttggtgct aaagtcaccg ttgcaaaaca agggttcatg
     2221 ttctttgatt taaaacgttc aagtgaacat gaccatgggt cttttgatga tattgatgtc
     2281 gataatgatt tcatcatgca tcacgttggt tttggtgttc gcaatatgat taaaattcgt
     2341 gccaaatacg ctaaacaata cggtaagaag tctgttcaag cacaattaat gaaaatactt
     2401 gtaaattcaa cctatggtaa aacggggcaa ggtattcatg ggaacacagc ccgtaacatc
     2461 ttaaacaatg aaactgaagt tataccattt tcaagaatta ctgacggtgt gattgcctca
     2521 acaacaactg cgcttgtacg aagtgtgttg ggcttgatta tgaattacat cgaccgtcta
     2581 ggttataccg ttcacagtgt aacgacagac gggttcattt ctgattttcc ttgggaaaga
     2641 atgctcgaaa ttgatgaata tttaagtggt atttctacgg tttttcaaaa agttattaaa
     2701 gcatgttggg gcgaaacgct tgattggtct accggtaaag gttctatttt ggaagttaaa
     2761 cacattcaag atgaattttt cttcaatgtt aaaacgagag gtaacatctc tttagatgtt
     2821 ggtaaacctt acacaaaccc ttatacaagc aacgttgaaa actatgatgg tgtttttgca
     2881 aaagccggtt ataaaggtga taacgatttt aaatatttaa ctgattacga caaacgcttt
     2941 aaattgctta atcaaattgt gaaccgtaac ggggcattaa ttgattatca aactgatatg
     3001 ttgtcattta gagaggttaa acaaagcaat ttaaaatcta tcaccaaggc ttatgattct
     3061 aaagaagatc ttgaaaagcg tttatccatg gacttcgata aaaagcgtat gttgttgcct
     3121 cgagagtttt caaatatcaa aacggatgtc tttaaatctg attatggttg gttcccaaca
     3181 cgtccatttg aaaatatgga agaatatgaa tataacgcag gcatacacaa gctattcatc
     3241 ggtaaagatc attgtattaa agatgattta acgtttactg catatcaata cgcattaaac
     3301 aacggttttc cgaaatataa acgggtcaat gagaaaaagc taacgagtga tgaacttgtt
     3361 gaacatcaac aaatagctaa aaagtatgat attaaacagt atttagttta tcttttaaaa
     3421 tttcctgaac tacatcccga agatgatttt ttacgggatg ttgaagattt ttcaagaaaa
     3481 gattatcttg atttaattct taaattggat ggtgtcgacg ctttagaaac ttggaaatct
     3541 attaaaaagc ggactaaaca cacatttgat ttattaactg cattagaata cgacaaacga
     3601 ttaaaacgtt tctactttaa cacgtactat tatgtgttaa gtgaagaaag ttattagtat
     3661 aataaaaaac aggaggggtg atattttggg tgtcgaacaa ttaaaacgac aacttgacgt
     3721 tgtatctcaa ttaaaaaata acgttgatga tacttctgtt gatgtgatga atcgtgaatt
     3781 agaatctgtt gtatttactg ttttatcatt atttggacat gatgatgaga acgtcgaaat
     3841 taatgaaact ttaaacagac ttcaacatca atcgcgcacc gatgaaccta cacataaaaa
     3901 taatttagca attttcgata gttttaaaaa attagaaaat ttgctcacac acgatgaacg
     3961 atttaaagaa tatttttaat aagtaaacgt agaaaaagca ctggtactaa agaccagtgc
     4021 ttttttgagt tcaacgagct ttagctcgta acagggagtt gaacgatcgt gataagtgtg
     4081 atattacaat ttatttgtca tattacttga tattatcata ccaatgtagt atacttaaat
     4141 ggaacaataa tgaatgttgt tgtgacggga tttaaattaa ccgttagggt ttacggtttt
     4201 atggaggtga attgatggca aaaataggtt atgcgagggt ctcaacaaaa gaacagaatc
     4261 ttgatttaca aattgagtat ttaaaaagtc atggcgttga cgatggtcta atatttgttg
     4321 ataaaggtgt atcgggtggc gttgcaccgg aacaacgtga tggttttaaa caactgttac
     4381 aaaaggctcg ttcaggtgac acattaattg tttataagtt ggatcgtatt tcacgtaagt
     4441 acgatgatgt tcaaactgta attaagacgc ttaaagacag tggcttaaat tttgaaatcg
     4501 gtgggctacc caacatcaac acgggtaaca aactgatgga taaagcttta acagatatgt
     4561 taataaactt attaggttat gttgcggaaa atgaacgagc gtacatcaaa gagcgtcagc
     4621 gtgatggtat agagcttgct aaaaagcaag gacgctttaa aggtaaacca aagaagtata
     4681 gtccacattc aaaagataag tacgggcgct atatttacaa tcaaattgtt gaagatttaa
     4741 acagtggtat gagttacaac gctgtaaggt taaaacatga agttggtatg agtacagtac
     4801 atcgtatcgc tcatgaaatt gaggaggata ataatggatc aaagtatagt aaaaaataaa
     4861 gaagattatg tgaaagatac ggaacagata cgacacaata tctctacaac acaagagcgt
     4921 ttcaataaag aaaagaacaa acttgctaac catcaacaca agtttgataa aatgcaactt
     4981 gaattcacta atgatatgtc tatgaagttg ttagataagg ttagttccgg tgaaattgat
     5041 gttaaggatt tacccaatat caaatcatat ttatttgatg atattggttc acttgatgta
     5101 tcaagtgagg ttcccgtttc atcatctgat acagatgaaa cggcacagtc tacatcatca
     5161 cattctgatg tagaccataa cccttttgct gacgctaacc gtcatagcta aaaggtatca
     5221 catcaccggc attgtgccgg tgatgttgca caccaaaggt gtgtactcgc tagagagtta
     5281 agagagagcg cagcgtctct cttacaagct cccaaatgtt tacattggga ctgcttgccc
     5341 cagatttata aggggtgcta tgcgttgagc gtagtgccct gcaataaatc gcatttgacg
     5401 tgttgcaatt gtcgcacatt tttttttgcg acgcaacacg tattttaata cacaattagc
     5461 ccactattat tgggcgtgta ttaaaatcaa tctttttgaa tttaaaggag tgaacatcat
     5521 gtcagatgta aaacataaat tacccgaaac agaacgcaaa acaaagacga ttgtgtttcg
     5581 gatacgtgaa gatgaatatg acaggttaaa gacactttca gatgaattaa gaggctataa
     5641 atcgccaaat gagattgccc ggttaattac attagaatgg ctcgaccata agcaaacgtt
     5701 taagccgaaa caagtatttg ataatgaaac gtttgaagtc atgaaagacc ttagaatttt
     5761 agcaagtgaa ttgcgaaacg atatccaagg tatcgcacga aactttaacc aatatataaa
     5821 gttattgaac acacgtaagt tacgcaatga attaagtgta gatgatttaa aaaacatcga
     5881 tgagttccgg caacagttta agaaaacgag aaaaaacatc ggtgatttta acagaaaggt
     5941 ggggtcatta tcgcaacaat ccaagtaagt tcaacacgca atgttcaaaa gtctattgat
     6001 tatgttttaa gttcaaaacc acactacaac catgaacata caaatgggcg tcgtgtacaa
     6061 gccgtttcgg gtttaaattt ggcgataact ggtgatagtg catttctagc taaaccacaa
     6121 atgcgtgacg tgcaaaaaca atataataaa caagaaggtt ttgttcaagg ttactcaatt
     6181 attgatagct attccgaaga tgaaatacct aaggacggta agcgttcaac aatccaactt
     6241 gtacacgaaa tgggtttaga aaaagcacgg cgcatttacg gtgaaaacta tcaatgtttg
     6301 gtagcgacac aatgcgatgg caagtctggg ttgtatcaca atcacctaat tagtaatgca
     6361 gtaggaaatg acggtaaatc acagcgaggt gacatgacca aatggacgaa actagctgaa
     6421 attagtgacc aagtcatgat tgattatggg tacacacctt tggacaaaaa caattggcgc
     6481 ttaaataaaa cacgtaaagc tgaagcacgt tcaaaaggtg aatatgtatc accgaatgag
     6541 cgaaaagcac gcaaaaacgg tatgacatta gccaaagacg aagtacgaga acaaattcaa
     6601 aaagttatag atgatgaaac tgtgaaatca tttgaagact ttaaacagat gttaaatgaa
     6661 gaatatcaga taggcgttga ggacgcagga actaaagatg gtgaaaacat caaatacagt
     6721 tttagttata ccaacaaaaa gggtgaaaca tctgaaaaga caattaaagc taaaacatta
     6781 agtaaagaag attacacgtt atcaggtgtt aaatcaaaaa ttgaagataa gctacttgaa
     6841 acaggcaact ttgaaatcaa tgagaatgat ttaacacaac agcaacaaca aatgttatcc
     6901 aatttaattg ttccggaaga tgatgaagat gaactagaac ttgaatttga tgatgagagc
     6961 ttagcatttt tagaccaaat taatgaggag gtaaaagaat atggcagaga aaaacacagc
     7021 tcaaaagcta ctcgaaacaa tcagcgagtt gaaaaacaac atcgagacca tcaacgacac
     7081 gtcgaaaaca acgaaagaag tacaacaaga actaaaagca gtagcaaacg agctaaagac
     7141 aaagacgcag gatttgaact tggatagcaa aacacacaaa gatattaaca ctttggcaca
     7201 aaaactggac acttacgcaa aacaagaccg taatatcaaa gtgtcgttgc aatcaagtga
     7261 cttgtacgac atcacaggtg cagttaagaa aggtttaaca gacaacctaa aaaaggcaac
     7321 ggaagacgtg gttaaagaaa ccaatgactt tagagttaag tcccaaaatg aaatcaagga
     7381 ggcaacaaac gaactgattt catattcaag gaagttgaaa gatgaaaccg aaaaatataa
     7441 gaagtggtat gtttcagcga tggtgggatt tgttgcattt gctgttgtgt tgttgctatt
     7501 cacaacgctt gctgatatgc catttttaga acatgcgtat caattcatcg caacaaagat
     7561 agaacacagc aaaacatggt atgtaacagg tctgtggtac cttgcatatc tcattacgcc
     7621 aatgttctgg gttggtgtcg taacgggtgt agcgtacatg ttacacaagt ggtacactga
     7681 ttgagaggtg gtacaatgtt aacgattaag caactcgccg ataaattagg ggtatcaaaa
     7741 ccgactatca cccgaaacaa gccggaacac atggagttta cagttatcga cggtgtgaac
     7801 tacatcgatg aaacactaga acaacagatt actcaaaaag tgttgcagaa taaaacacga
     7861 tacagtggtg atagatcaac cgaaacaaac gacagtacat tagtacaaca gttgttgcaa
     7921 gagaatgcgt ttctcagagc acaaattgaa gaaaaagacg cattactgaa gacacaagca
     7981 aagttattag atcaacaaca acagtaa
//
