LOCUS       CP155663               10046 bp    DNA     circular BCT 20-MAY-2024
DEFINITION  Klebsiella pneumoniae strain 34 plasmid p34-3, complete sequence.
ACCESSION   CP155663
VERSION     CP155663.1
DBLINK      BioProject: PRJNA1110044
            BioSample: SAMN41316932
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 10046)
  AUTHORS   Kuo,P.Y.
  TITLE     urinary tract infection
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10046)
  AUTHORS   Kuo,P.Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-MAY-2024) College of Life Sciences, National Yang Ming
            Chiao Tung University, Linong Street, Taipei 112, Taiwan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. v2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 17.0x
            Sequencing Technology :: Illumina NovaSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 05/14/2024 15:22:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,504
            CDSs (total)                      :: 5,378
            Genes (coding)                    :: 5,250
            CDSs (with protein)               :: 5,250
            Genes (RNA)                       :: 126
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 90
            ncRNAs                            :: 11
            Pseudo Genes (total)              :: 128
            CDSs (without protein)            :: 128
            Pseudo Genes (ambiguous residues) :: 0 of 128
            Pseudo Genes (frameshifted)       :: 54 of 128
            Pseudo Genes (incomplete)         :: 76 of 128
            Pseudo Genes (internal stop)      :: 16 of 128
            Pseudo Genes (multiple problems)  :: 18 of 128
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..10046
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="34"
                     /isolation_source="urine"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="p34-3"
                     /geo_loc_name="Taiwan"
                     /lat_lon="23.00254450 N 120.21938242 E"
                     /collection_date="2009-01-30"
                     /collected_by="NCKUH"
     gene            complement(join(9039..10046,1..681))
                     /locus_tag="ABDW71_00005"
     CDS             complement(join(9039..10046,1..681))
                     /locus_tag="ABDW71_00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000012966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="XAX69592.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IMTSLPADAVTETPASTLPLDQATVRVRQRVVDVVKDERQHIAVVAGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPTAKAPPKGIVAEKGDSRPAGFTAGGNSREAVIR
                     FPKETGQKPVYVSVTDVLTPAQVKQRQEEEKRRQQAWDAAHPEEGLKRDYDKAKAELDA
                     EDKNIATLNSRIASTEKALPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQASLNAMNESLSRDKAALTGAMESRKQKEKKAKDAENKLNE
                     EKNKPRKGVKDYGHDYHPAPKTEEIKGLGELKKAPKKTPKQGGGGRRDRWIGDKGRKVY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQIKGPDPKGRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            complement(1266..1784)
                     /locus_tag="ABDW71_00010"
     CDS             complement(1266..1784)
                     /locus_tag="ABDW71_00010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="XAX69593.1"
                     /translation="MQKVTDLYPPEIARHKLQNHFAGNTVMLELIQKLNKTSLCTFAAL
                     CDGNVVTTSGYNITADLCVNRASAVAHSLKQKYLPVTARTISTKADVGGAVKQAAFCID
                     EDDLARLKSEPEKMMKECERNLNSQKRTNAQKEMSRLYKEFGEDGILALLRNVAQSNGT
                     PPPGAHPAS"
                     /name="hypothetical protein"
     gene            2557..2820
                     /locus_tag="ABDW71_00015"
     CDS             2557..2820
                     /locus_tag="ABDW71_00015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="XAX69594.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="plasmid stabilization protein"
     gene            2810..3109
                     /locus_tag="ABDW71_00020"
     CDS             2810..3109
                     /locus_tag="ABDW71_00020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010848978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0008657 - DNA topoisomerase type II (double strand cut,
                     ATP-hydrolyzing) inhibitor activity [Evidence IEA];
                     GO_function: GO:0042803 - protein homodimerization activity
                     [Evidence IEA]; GO_process: GO:0030541 - plasmid
                     partitioning [Evidence IEA]; GO_process: GO:0051290 -
                     protein heterotetramerization [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="XAX69595.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYEVDDPAQKVRVLAVVGQRQNPHTVR"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(3171..3548)
                     /locus_tag="ABDW71_00025"
     CDS             complement(3171..3548)
                     /locus_tag="ABDW71_00025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 1"
                     /protein_id="XAX69596.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQGETHERDGLRLPDETEKTASEALIAEIKALREEVAGLRQEMQAMRLLEH
                     KPETVETPAETPRRWWHWGKR"
                     /name="entry exclusion protein 1"
     gene            3618..3797
                     /locus_tag="ABDW71_00030"
     CDS             3618..3797
                     /locus_tag="ABDW71_00030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="XAX69597.1"
                     /translation="MTKQEKTALNMAKFIRDQSLLLLEKLNELDMDDPADMCERLHEDA
                     EKLWLVMRGKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(3825..4355)
                     /locus_tag="ABDW71_00035"
     CDS             complement(3825..4355)
                     /locus_tag="ABDW71_00035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="XAX69598.1"
                     /translation="MALYMVFIEDVEDKDGERCIMPTSEHLEDMAVMAWQTGAYVFRFE
                     DQAQHLAMMKFIGMYHERLNSDDKATYYFTGKNPAWERDKPSGMKLCDYLYRKVEQFAI
                     ENGVQVLDAGKYTPEQIGAMIDVVSERHGESAVNEKLKAELMREYNSRYFNEPVPVLPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(4362..5093)
                     /locus_tag="ABDW71_00040"
     CDS             complement(4362..5093)
                     /locus_tag="ABDW71_00040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-relaxation family protein"
                     /protein_id="XAX69599.1"
                     /translation="MALEQYNVSHAKRQARNAEKTRLVLRWLRDELCSTAETVARLLGI
                     GAVQPVYRFLDSLVAKGLLARAKYPVDGRQVSVWGLTPHGVAFSFDEDEPLTDVIPFQP
                     SRVSAAQLPHRLAVQSLRLDMEARGATGWRTLHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRPTLVRVQRAILAVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="replication-relaxation family protein"
     gene            complement(5093..7054)
                     /locus_tag="ABDW71_00045"
     CDS             complement(5093..7054)
                     /locus_tag="ABDW71_00045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="XAX69589.1"
                     /translation="MLNTDSLAWQWHIPELARQIYPWVSWLYREYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNDRAAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLVLLGGLVVAVFIESWGETVLRPGYYANADYYLLQPANLFGIAWCAGGLV
                     VGILLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSTEQARQQQVVFLGKDEDGQPVRVPREAWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLV
                     AGFNLAETGDVADHYRISEQKAAKLIAEQFPHGANIQQVLAAAYALPEALKKDVKGLIT
                     KLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFRAWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPADFV
                     KTTVLDNTPIRWFYRAASQESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARLAFSSPLRVDRREIPLKTFPVLAKTDPLAEY
                     QAEAVRQRPGDDDFAGLY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(8538..8687)
                     /locus_tag="ABDW71_00050"
     CDS             complement(8538..8687)
                     /locus_tag="ABDW71_00050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_component:
                     GO:0019867 - outer membrane [Evidence IEA]; GO_process:
                     GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="XAX69590.1"
                     /translation="MKKVKVVFLFILIFLGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(8772..9029)
                     /locus_tag="ABDW71_00055"
     CDS             complement(8772..9029)
                     /locus_tag="ABDW71_00055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="XAX69591.1"
                     /translation="MGLKLNLTWFDKKTEEFIGEEYSKDFGDDGSVIESLGMPLKDNIN
                     NGGFDVEKPWVPLLQPYFKNKIEVDKYWYQISFDYRDGNW"
                     /name="cloacin immunity family protein"
     BGC             1..10046
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          7857..8435
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="98.454"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(4366..5093)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="94.239"
                     /coverage="100.0"
                     /evalue="1.14e-141"
ORIGIN
        1 ccccggacgt tttgtcggtt tcgcatccac cacagggaca ctcattggcc gacctgcgac
       61 aaccgcaata tgctgccgct catccttcac cacatccaca acccgttgtc tgacacgaac
      121 cgtcgcctgg tccagtggta aagtacttgc cggagtctcc gtcaccgcat cggccggtaa
      181 tgacgtcata atttttgaca tcattttcgg atcatctttt gcaatctcag aaggcagcac
      241 accgtagatc gcaatccccc acagaccaaa cttaaacggc cccttcaggg cagccagcac
      301 atcagcaacg gcggccgaca acgcatcgcc ggaaactgat aaagccagtc cttcagcccc
      361 cggagtagcc agggcaggca gaccgaaagc catcgcagtg gccgaagact gtccgccacc
      421 agagctaccg ctatgattgc cgctgttacc accattacca ccgggtttac tcccgccgtt
      481 accaaactcc cccggattat agttatgaat atctccattc ggcgtatgcg tcgtacccca
      541 gcccggcccg ctgtttggat ccgtaccacc acctgatgaa gggccacctt taccagacgt
      601 accgttcaca ttcccactgg cctgaccacc attatgtccc agacctgaat tacccggacc
      661 tcgaccgtct ccaccactca tatcgttttc ctctttgaca tttaaaacaa taaattaaaa
      721 ccaatatact gtatatatac acagtgtaat tgttacctta ctcctccagt tttcaggtgt
      781 caatatatga gattagttct catcttcagg cacaaaaaag cgcccggagc cgcctgtaag
      841 cagatcgcgt cttttcccga aaatttctca tggcaacaaa ttttattatt tgagatattc
      901 atcacactta cttttatatt ggtatagatg tacctgaaag cgaaatggca tgaggagagt
      961 acctgcggtt aaactgttca ggaatcggag acaacccgga ggccaccatg acgcacctga
     1021 agaaaagcgc ctggcggacg cctttgtcgc tcaggcactg gccatgggcc tgaaaggggt
     1081 tcgaggtcca accgtacgaa aatgtacggt aagagtgaaa ttctcgtccg aaagaaggaa
     1141 aagcaaaact ggtaacgcca ccgccggtag aagggaacta tctgcaccgc gattagctga
     1201 cagatcaaga gctggcggca tccagaaaac cttaaaaata aagcccctta ggggctttac
     1261 tggtatcaac ttgcagggtg tgcgcctggc ggcggtgtac cgttcgactg ggcaacattg
     1321 cgtaacagcg ccagtatgcc gtcttcacca aactccttgt acaaccggct catttccttc
     1381 tgagcattgg tgcgcttctg gctgttcagg ttacgttcgc actctttcat catcttttcc
     1441 ggctctgatt tcagccttgc aagatcgtcc tcatcgatac agaaagccgc ctgctttacc
     1501 gcaccaccta catcagcctt tgtcgaaatc gttctggccg taactggcag atatttttgc
     1561 ttaagcgaat gggccacggc tgacgcacgg ttaacacata gatcggccgt gatgttatag
     1621 ccggaagtgg tcactacgtt gccgtcacag agcgccgcaa aagtacacag gctggtttta
     1681 tttagtttct ggattaactc cagcataacg gtattaccgg cgaagtgatt ctggagctta
     1741 tggcgagcaa tttcaggagg atacagatca gttacttttt gcatttatag cacctgttta
     1801 cagaggataa ataacaggtg acggtgtccg gatgagcatt cgcacatcaa aaaactgtga
     1861 aaaatgcctg gcaagtcggt accaagttac tacataatgc agcaccactt gacaaacgcc
     1921 ctaatcgggc gtttgttgat caggtaagat tcagttttca cgaactgagt caccggcagc
     1981 tatcagaatc cttagtttct caggccgaag atctgatagc tgcctcgttt ttcactgaca
     2041 acctcacgat catcagaatc ccttattcta ccttattcca taagcgcaca catagctttt
     2101 ttgcagatct ttcgcgcttg atttacaagg aaattacctg tctggtcgat gaaattagca
     2161 acagcgctat cagatgacgc taatgttaaa ctcatgttta aacatacagc gaaaagttga
     2221 cgcaaaaatc gtcagctgaa tgcctcataa ccagccattt accataacat ccgttgcccg
     2281 caccccctga gagcctctga gggcatttct gacgggaaac cgataaaaca gacaacaaac
     2341 cacccgcaac acccccggaa acgcgccgga taaattgtac ctgaacgcat ggctatgcac
     2401 gtaactgcat ggcatgggat ttgacgtaaa atggatgccg taagcccttt tttaccgact
     2461 ttctgcttca tcagcctgac tgacacgagc atattctttc aggccgcctc ctgctaaact
     2521 ttttcatatt gccgcattaa cccgggaggc tccgcaatga gcaacacgac acactacgaa
     2581 aacgccaact ttcttcggga actggctgaa agcctgcccc gcatactgcc ggaaggtggc
     2641 ccggacaaag ctgcgctgtt gcagcgcctg gctaacgaag aactggccca ggcagagtat
     2701 gaagatcagg ttcgcgccaa agtgaccgcc gcccgtgctg acacgcgtcc gggcatgacc
     2761 acggaacaac tccgccagcg cctgcatggc cgttatcagg aactgcgcga tgccgtatga
     2821 cgtggaatgg aagcagggag ccatcgaaga tgtaacgaca ctgtttgact atatcgcgga
     2881 aaattcatcg ctgtgggatg cgcagaacgt taccgaccgg gttctcgctg ctgcggacaa
     2941 actggcggac ttcccgcgcc tctacgaagt ggactcacgt tatggcgaag acgttcgccg
     3001 gatcagcctg atgggacaac atgtcctcta tgaagtggac gaccccgcgc agaaagtccg
     3061 ggttctggcc gtggtcggcc agcgccagaa tccccatacc gttcgctaat aaccggtgac
     3121 aggggcgcaa ttcattgcgt gcccgtcgcc ggttggacaa gcgcagcgcg tcagcgtttt
     3181 ccccaatgcc accaccggcg cggcgtttcg gccggtgtct ctacggtctc cggtttgtgt
     3241 tccagcagtc tcatggcctg catttcctgc cgcaacccgg ccacctcctc cctgagtgct
     3301 tttatctccg cgatcaacgc ttcagaggcc gttttttcag tctcatctgg cagtctcaac
     3361 ccgtcccgct cgtgagtctc accctgtctt aactcaccgt acacccggat aagctcgctg
     3421 gtatccacaa cccgaccgcc atcagcctcc gtccggtatg atacgcggcc tttcgccata
     3481 tcccggtaca gggaactccg ggctttcccc gtcagttccg tcgcctgtct caccgtcacc
     3541 cacgccattg tctcaccccg ctatttttga gacagtatac ccgactggcg cacaccatgc
     3601 ccggaaggga aaaaatcatg acgaagcagg aaaaaaccgc cctcaacatg gcaaaattca
     3661 tcagggatca gtcgctgctg ttgctggaaa agctgaacga gctggacatg gacgacccgg
     3721 ccgacatgtg cgaacgactt cacgaggatg cggaaaaact ctggctggta atgcggggta
     3781 agctcgggga agaataacag caccggcatg gccggtgctg gcgtttattt tttgccgaac
     3841 ggccaccacc ggcgggcggg tttatcctcc ggcaatacgg gcaccggctc gttaaaatac
     3901 cggctgttat actctcgcat cagctccgct ttcagcttct cgttcaccgc actctcaccg
     3961 tgccgctcac tcaccacgtc aatcatcgcg ccgatctgct ccggggtgta cttccctgcg
     4021 tccagtacct gcacgccgtt ctcgatggcg aactgctcaa ccttgcggta aagataatca
     4081 cacagcttca ttccggacgg tttatcacgt tcccacgccg gatttttgcc ggtgaagtaa
     4141 tacgtggctt tgtcatcgct gttcagccgt tcgtgataca tgccgataaa cttcatcatc
     4201 gccagatgct gggcctgatc ttcaaaccgg aatacatatg ccccggtctg ccaggccatg
     4261 accgccatgt cttccagatg ctcgctggtt ggcataatgc agcgctcgcc gtctttgtct
     4321 tccacatcct caataaaaac catgtacagc gccataatcc ctcactctgt tgtcataaat
     4381 ttaaagcacg cgaacagcct ctcccggtcc agttccgccg ttttgcgggc ttcgccggtc
     4441 tgcgggttca cgatttcatc caccgccaga atcgcccgct gtacccggac aagcgtcggc
     4501 cggtcggggc agatgtacca gatttcatcg atgccgttcg ccttacggtt gaacagatac
     4561 ccggacacca cttcctgata ccggcgacgg ctcttgacgg tgcgctccac ctcaaacgcc
     4621 accgttttac cgtccagctc tgccagcgca tccggcacct tcataccttt aagactcagg
     4681 cggtgcaggg tgcgccagcc ggtggcccct ctggcttcca tatcaagacg cagggactgc
     4741 acggccagcc ggtgcggcag ctgcgccgcc gacacccgcg agggctgaaa cggaataacg
     4801 tccgtcagcg gctcgtcctc gtcgaacgag aacgccacgc cgtgcggggt cagcccccac
     4861 acgctgacct gacgaccgtc aaccgggtat ttcgcccggg ccagcagtcc tttcgccacc
     4921 aggctgtcca gaaagcggta aaccggctgc accgccccga tccccagcag acgggctacg
     4981 gtttcagccg tcgagcagag ttcgtcccgc agccaccgca ggactagccg ggttttctcc
     5041 gcgttccgcg cctgtcgctt cgcgtggctg acgttgtatt gctccagagc catcagtaca
     5101 gccccgcaaa atcatcgtca cccgggcgct gccgcactgc ctcagcctgg tactccgcca
     5161 gcgggtccgt tttcgccagc accgggaagg ttttcagcgg aatttcccgg cgatcaaccc
     5221 gcagcgggct gctgaacgcc agccgcgcca cgcccagccc ggtcatgacc gcgaacccgt
     5281 ccggcaggtg ttgcagggtg ttcacgtcga acagcggccg cgcttccttc tggatgaagc
     5341 tgtccccgct gatgtgctcc acgttccccg cctcccggct ggcccggcgg cgctccacgt
     5401 ccacccggat ttccccggtc tgtccggccg cccactgcgc ggactcctgg ctggccgcgc
     5461 gatagaacca gcggattggc gtgttatcca gtaccgtggt tttcacaaaa tcagcgggca
     5521 gatcctgccc gcactggccg aagtcgccca gcgactggtg agccagcagc aggttacagt
     5581 cccggctgcg cagcgtcccc agcgcgttga gtacgtactt cgagagcaga tatttgattt
     5641 catcgagcat cacgctgacg tgcggccacg cgcggaactc gtcccgcgca atgatgattt
     5701 gcgcgcagcg ggcaaacagc attttctgca cccggatcac cgcctcgtcg tccatcgatc
     5761 cgatgacgta cagacagccg ccgccgttga taatccccgc cacatcaata ccggaatccg
     5821 tctgcaggac gctcaggtcc gcgacgttct ccagcttggt gatcagcccc ttcacgtcct
     5881 ttttcagcgc ctccggcagc gcatacgccg ccgccagcac ctgctgaatg ttcgcgccgt
     5941 gcgggaactg ctccgcgata agcttcgccg ctttctgctc gctgatgcgg tagtggtcgg
     6001 ccacatcgcc ggtttccgcc aggttaaacc cggcaaccag cagatttttc agtgcgtact
     6061 ggtcaaggtc gcggaacagg ttcagctgcg ccggtttccc cggccgcagg tccagcaggg
     6121 tgaagtccgg gcagtgcgcc cgaaagacgt gtggcgccca tgcgtcgcct ttcgggtcga
     6181 agtacaccac cgcatcgcca aaatcgcgca cgcagcggat cagcgcgttg gtggccatca
     6241 cgctcttgcc gctcccgggt aggccgagga tctgaatatt ggtcttgcgc cacgcctcgc
     6301 gcggaacccg caccggctgg ccgtcctcgt ccttacccag gaacaccacc tgctgctgcc
     6361 gggcctgctc cgtggaaaaa tcggccagcg cgttgaccgg caccggctcc ccgaaatgca
     6421 ggtggcgcac gtcagtcatt tcgccggtgc gctggctgct gcgccggctc tcctgattca
     6481 gttttgcatt gaccgcctcg tcagcggccg caaaatgacc gtcaagcagc aggaatgcca
     6541 gtagccgcgc cagaagtatc ccgacgacca gaccaccggc acaccaggct atcccgaaca
     6601 gattagcggg ttgcagcagg taataatcgg cattcgcgta gtagcccgga cgcaacaccg
     6661 tttctcccca gctctcgata aacacggcga caaccagccc ccccagcaga accagaccgg
     6721 cagcgccggt cagccagtac gcgtagttcc agacatgtcg acgagccctg accatccgcc
     6781 cgggagaatc cagcgaggcc agcaccgaaa atggcgcagc cctgtcatta tcgcgcttat
     6841 agcgatcggc atactcccgc cgctccttat ggctcaggcc cacaaaacgc atccgtccgg
     6901 cccagagttc agccagaccg aaaaacaggc cgataaccag aaaagccccg gccagaccgt
     6961 aatactcccg gtacagccag ctgacccacg ggtaaatctg ccgggccagc tccgggatat
     7021 gccactgcca ggcaagcgaa tccgtattca acatgcaacc tctctcctac agacgacgga
     7081 tttaccggcg tgatgcgcag cccatctgcg caagctgacg acatgcccca aggcatggcg
     7141 gcggcgttca cgtccgtggt gaaagcgttc agcgctcgcc acggaggcca gcctctttcc
     7201 gccccatgcg gaaaaggcgc agccccggag gaacaacgag cacgcccaca gcgtgcgaga
     7261 ggaaaaggcg gcaccccagt gctgtctttt ccggtgttcc ggcccccgtc agagtaagcg
     7321 acagcgagcg gctgaccacc cataaaatca ggagcagctt tgctgcttcg tcaggtgcgt
     7381 ccagcaccgt ggatttttgt gggtggtcag gcgtgagcct gacgggggcc gggtgaattt
     7441 ctggcgtgac cggcgtccag ccggacagag ccagaaagag ggggaaagac cgtgcgtcgg
     7501 tggcgtccag ccagcgtaag caggggattt ccccctgaag tcagccacgc cccagcgggg
     7561 atgacttgca tttctccgca aggagaaaaa agcaacagag ataggttaac ttaaaatgtt
     7621 cagcgaaaaa ccgacatggt tcacctattc ggataattga tcgtcaggga atagaaagac
     7681 ttaatcaggg gacaatatcc cacatcagcg cgtccggtga ccgtcttgca ggtgccgggg
     7741 aaattgcgcc tcctcgctca ctcggtcgct acgctccggg cgtgagactg cggcgggcgc
     7801 tgcggacaca tacaaagtta cccacagatt ccgtggataa gcaggggact aacatgtgag
     7861 gcaaaacggc agggccgcgc cggtggcgtt tttccatagg ctccgccctc ctgccagagt
     7921 tcacataaac agacgctttt tcggtgcatc tgtgggagcc gtgaggctca accatgaatc
     7981 tgacagtacg ggcgaaaccc gacaggactt aaagatcccc accgtttccg gtaggtcgct
     8041 ccctcttgcg ctctcctgtt ccgaccctgc cgtttaccgg atacctgtcc gcctttctcc
     8101 cttgcgggaa gtgtggcgct ttctcatagc tcacacactg gtatctcggc tcggtgtagg
     8161 tcgttcgctc caagctgggc tgtaagcaag aactccccgt tcagcccgac tgctgcgcct
     8221 tatccggtaa ctgttcactt gagtccaacc cggaaaagca cgcaaaacgc cactggcagc
     8281 agccattggt aactgggagt tcgcagagga tttgtttagc taaacacgcg gttgctcttg
     8341 aagtgtgcac caaagtccgg ctacactgga aggacagatt tggttgctgt gctctgcgaa
     8401 agccagttac cacggttaag cagttcccca actgacttaa ccttcgatca aaccacctcc
     8461 ccaggtggtt ttttcgttta cagggcaaaa gattacgcgc agaaaaaaag gatctcaaga
     8521 agatcctttg atcttttcta ctgaaccgcg atccccgtca gttcagagga ggacgatggt
     8581 gccaccgttc caccctgaac atcccggata tagtttgcct gacatgcgac cagaagaaag
     8641 cctaaaaaaa tcaatataaa aagaaaaaca acctttacct ttttcatata ccttccctgt
     8701 atttaaaaac cccggcattc atccctgaac accggaagtc tgtatttcaa atcatccttg
     8761 ataatttttt gttaccagtt accgtcccga taatcaaatg aaatttgata ccagtactta
     8821 tcgacttcaa ttttattttt aaaatatggc tgcaacaacg gaacccatgg tttctcaaca
     8881 tcaaacccgc cattgttaat attatccttt aaaggcattc caaggctttc aatgacagaa
     8941 ccatcatcac caaagtcttt agaatactcc tcaccaataa attcctcagt cttcttatca
     9001 aaccaggtta aatttaattt aagccccata cttacctctc aaagatattt tttaatgttt
     9061 cgtcctttcg gatccggacc tttaatttgc ttacccgttt ttggatcaaa tgccccgagg
     9121 tgttcgccat cactggcacg atacccttca agctcaccgt gctgggagtc ccattcataa
     9181 accttacggc ctttatcacc aatccaacgg tcacgtctac caccaccacc ttgtttaggt
     9241 gtttttttag gtgctttttt taattccccc aaccccttga tttcttcggt cttcggagcg
     9301 ggatgataat catgaccgta atctttaact cccttgcgag gcttgttctt ttcctcattt
     9361 aacttatttt ctgcatcctt cgcttttttc tccttttgtt tccggctctc catcgccccg
     9421 gtaagtgcag ccttatctct ggataaggat tcattcattg cgtttaaaga tgcctgagcc
     9481 gcttttaatt tctcattctg attctgaata tccttatcaa gatagcgaac ctgatcctgc
     9541 cacccggagc catattcatg aggcgggtta taagtcacaa aatcatcttt atttgcctct
     9601 gcctctttta cctttttatc ggcttcctga acagcagccc ttgcaccggg gagcgccttc
     9661 tctgtcgatg caatgcggct gtttaaggtc gcaatatttt tatcttcggc atccagctca
     9721 gctttcgctt tatcatagtc tcttttcagc ccctcttccg gatgagcggc gtcccatgcc
     9781 tgctggcgac gcttttcttc ctcctgacgc tgttttacct gtgccggggt aagaacatct
     9841 gtcaccgaca cataaaccgg cttctgtcct gtctctttcg ggaaacgaat aacggcctca
     9901 cgggagttac caccggctgt aaaaccagcc ggacgtgaat cacctttttc agcaacaatg
     9961 ccttttggcg gggctttcgc tgtcggaaca cctttcggta cgctcacctg cagagacggg
    10021 agacccggaa tcgacacact gaatac
//
