LOCUS       CP154382               23005 bp    DNA     circular BCT 06-MAY-2024
DEFINITION  Staphylococcus aureus strain BSN197 plasmid pUSA04, complete
            sequence.
ACCESSION   CP154382
VERSION     CP154382.1
DBLINK      BioProject: PRJNA1048360
            BioSample: SAMN38637777
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 23005)
  AUTHORS   Berti,A.D., Gurdziel,K. and Liu,W.
  TITLE     Pre-publication release of Staphylococcus aureus str BSN197 whole
            genome sequence
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 23005)
  AUTHORS   Berti,A.D., Gurdziel,K. and Liu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-APR-2024) Pharmacy Practice, Wayne State University,
            259 Mack Ave, Detroit, MI 48201, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2024
            Assembly Method                   :: SPAdes v. FEB-2024
            Assembly Name                     :: BSN197
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: CP043386, CP014442, CP014445
            Genome Coverage                   :: 130.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/30/2024 10:29:23
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,928
            CDSs (total)                      :: 2,846
            Genes (coding)                    :: 2,759
            CDSs (with protein)               :: 2,759
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 87
            CDSs (without protein)            :: 87
            Pseudo Genes (ambiguous residues) :: 0 of 87
            Pseudo Genes (frameshifted)       :: 47 of 87
            Pseudo Genes (incomplete)         :: 44 of 87
            Pseudo Genes (internal stop)      :: 16 of 87
            Pseudo Genes (multiple problems)  :: 19 of 87
            ##Genome-Annotation-Data-END##
            Bacteria and source DNA available from Andrew D. Berti, Wayne State
            University, Detroit MI  USA.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..23005
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="BSN197"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pUSA04"
                     /geo_loc_name="USA: Detroit, MI"
                     /lat_lon="42.33 N 83.05 W"
                     /collection_date="2018-01-22"
                     /collected_by="Andrew D. Berti"
     gene            join(22796..23005,1..465)
                     /locus_tag="UXR18_14510"
     CDS             join(22796..23005,1..465)
                     /locus_tag="UXR18_14510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004803 - transposase activity [Evidence IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="XAL18437.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            606..1241
                     /locus_tag="UXR18_14515"
                     /pseudo=""
     CDS             606..1241
                     /locus_tag="UXR18_14515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009251744.1"
                     /note="internal stop; incomplete; partial on complete
                     genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /name="aminoglycoside 6-adenylyltransferase"
     gene            1238..1684
                     /locus_tag="UXR18_14520"
     CDS             1238..1684
                     /locus_tag="UXR18_14520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000627290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0008080 - N-acetyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="XAL18438.1"
                     /translation="MITEMKAGHLKDIDKPSEPFEVIGKIIPRYENENWTFTELLYEAP
                     YLKSYQDDKCVGKVKLRKNWNRYAYIEDIAVCKDFRGQGIGSALINISIEWAKHKNLHG
                     LMLETQDNNLIACKFYHNCGFKIGSVDTMLYANFEKAVFWYLRF"
                     /name="GNAT family N-acetyltransferase"
     gene            1777..2571
                     /gene="aph(3')-IIIa"
                     /locus_tag="UXR18_14525"
     ARG             1778..2568
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            3053..3528
                     /locus_tag="UXR18_14530"
                     /pseudo=""
     CDS             3053..3528
                     /locus_tag="UXR18_14530"
                     /inference="COORDINATES: protein motif:HMM:NF024676.4"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="WYL domain-containing protein"
                     /name="WYL domain-containing protein"
     gene            complement(3587..4261)
                     /locus_tag="UXR18_14535"
     CDS             complement(3587..4261)
                     /locus_tag="UXR18_14535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004803 - transposase activity [Evidence IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="XAL18440.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            4523..4708
                     /locus_tag="UXR18_14540"
     CDS             4523..4708
                     /locus_tag="UXR18_14540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="XAL18441.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            complement(4931..5509)
                     /locus_tag="UXR18_14545"
     CDS             complement(4931..5509)
                     /locus_tag="UXR18_14545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="XAL18442.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(5773..6153)
                     /gene="blaI"
                     /locus_tag="UXR18_14550"
     ARG             complement(5777..6153)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.41"
                     /coverage="100.0"
     gene            complement(6143..7900)
                     /gene="blaR1"
                     /locus_tag="UXR18_14555"
     ARG             complement(6147..7900)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.38"
                     /coverage="100.0"
     gene            8007..8852
                     /gene="blaZ"
                     /locus_tag="UXR18_14560"
     ARG             8008..8849
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(9378..9797)
                     /locus_tag="UXR18_14565"
     CDS             complement(9378..9797)
                     /locus_tag="UXR18_14565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="XAL18446.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            9921..10892
                     /locus_tag="UXR18_14570"
     CDS             9921..10892
                     /locus_tag="UXR18_14570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="XAL18447.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(11064..11156)
                     /locus_tag="UXR18_14575"
     CDS             complement(11064..11156)
                     /locus_tag="UXR18_14575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="XAL18448.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(11313..11660)
                     /locus_tag="UXR18_14580"
     CDS             complement(11313..11660)
                     /locus_tag="UXR18_14580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]; GO_process: GO:0006355 - regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="XAL18449.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(11679..12296)
                     /gene="cadD"
                     /locus_tag="UXR18_14585"
     ARG             complement(11683..12296)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(13412..13606)
                     /locus_tag="UXR18_14590"
     CDS             complement(13412..13606)
                     /locus_tag="UXR18_14590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="XAL18427.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            13716..14408
                     /locus_tag="UXR18_14595"
     CDS             13716..14408
                     /locus_tag="UXR18_14595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative immunity/bacteriocin fusion bifunctional
                     protein"
                     /protein_id="XAL18428.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="putative immunity/bacteriocin fusion bifunctional
                     protein"
     gene            complement(14576..14725)
                     /locus_tag="UXR18_14600"
     CDS             complement(14576..14725)
                     /locus_tag="UXR18_14600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="XAL18429.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(15301..15591)
                     /locus_tag="UXR18_14605"
                     /pseudo=""
     CDS             complement(15301..15591)
                     /locus_tag="UXR18_14605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009384749.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(15611..16594)
                     /locus_tag="UXR18_14610"
     CDS             complement(15611..16594)
                     /locus_tag="UXR18_14610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="XAL18430.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFENRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            17020..17763
                     /locus_tag="UXR18_14615"
     CDS             17020..17763
                     /locus_tag="UXR18_14615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="XAL18431.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(17990..18175)
                     /locus_tag="UXR18_14620"
     CDS             complement(17990..18175)
                     /locus_tag="UXR18_14620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="XAL18432.1"
                     /translation="MKNRIREYRKQKGISQETLSKELKVSRQTINAIENNKYDPTLTLA
                     FKLARLFDTTVDELFS"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(18180..18518)
                     /locus_tag="UXR18_14625"
     CDS             complement(18180..18518)
                     /locus_tag="UXR18_14625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="XAL18433.1"
                     /translation="MNLIPFIIILIFSCLWTAITNKYLPSETLDKKGQQDRYDERQRKM
                     FIEILAKSFIWIVYCMLFTLVLKFTGLSPSIEGSWFSQYPEIFFIIVALFLMLFNYYTT
                     NKKYTSKG"
                     /name="hypothetical protein"
     gene            complement(18764..19372)
                     /locus_tag="UXR18_14630"
     CDS             complement(18764..19372)
                     /locus_tag="UXR18_14630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="XAL18434.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTFGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKDVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGKAISKIAKEVNITRQTVYRIKHDKGLS"
                     /name="recombinase family protein"
     gene            complement(19858..20757)
                     /locus_tag="UXR18_14635"
     CDS             complement(19858..20757)
                     /locus_tag="UXR18_14635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000196697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mph(C) family macrolide 2'-phosphotransferase"
                     /protein_id="XAL18435.1"
                     /translation="MTRHNEIIKCAEKYQLHIQPQTISLNESGLDFQVAFGKDKHGVEW
                     VLRLPRRPDVYKRTKPEKQTVDFLQKNVSFEIPKWKVHAKDLIAYPKLTGKPAATIDPE
                     IQNYVWEIEHKPLPENFINTLAETLVDLHNIPEENINVQHINIKTIQEIKNDFQRRMNK
                     VKETYGVSDELWNRWKQWLENDELWPRHATMIHGDLHPGHIMVDNQANVTGLIDWTEAT
                     HSDPSMDFIGHHRVFDDEGLEQLITAYGKAGGEIWPRMKEHIIELNAVFPMFIAEFAME
                     SGESAYETMALKELGMKE"
                     /name="Mph(C) family macrolide 2'-phosphotransferase"
     gene            complement(20856..22322)
                     /gene="msr(A)"
                     /locus_tag="UXR18_14640"
     ARG             complement(20860..22322)
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(19862..20757)
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(20857..22322)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             complement(19859..20757)
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             643..944
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.0"
                     /coverage="36.23"
     ARG             8008..8852
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     Typing          complement(15067..15231)
                     /name="MOB_unknown"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="2.42e-81"
     Typing          complement(15304..15480)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="92.697"
                     /coverage="94.0"
                     /evalue="2.89e-66"
     Typing          complement(15612..16594)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.492"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          17021..17763
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 tacaaatggc gtattgatga gacgtatatc aaaataaaag gaaaatggag ctatttatat
       61 cgtgccattg atacagaggg acatacatta gatatttggt tgcgtaagca acgagataat
      121 cattcagcat atgcgtttat caaacgtctc attaaacaat ttggtaaacc tcaaaaggta
      181 attacagatc aggcaccttc aacgaaggta gcaatggtta aagtaattaa agcttttaaa
      241 cttaaacctg actgccattg tacatcgaaa tatctgaata acctcattga gcaagatcac
      301 cgtcatatta aagtaagaaa gacaaggtat caaagtatca atacagcaaa gaatacttta
      361 aaaggtattg agtgtattta cgctctatat aaaaagaacc gcaggtctct tcagatctac
      421 ggattttcgc catgccacga aattagcatc atgctagcaa gttaaacgaa cactgacatg
      481 atatattagt gattagctat attttttact ttgcaacaga accatcattt ttattaaaat
      541 actcttttgt aaaatctttc tgctcttcaa tgtatttaat ttctttacct ctaaatctat
      601 tatagctatt tgatgattac aataaaattg atcttacctt attgcccttg gaagagttag
      661 ataattacct aaagggcgat aaattaataa aggttctaat tgataaagat tgtagaatta
      721 aaagggacat agttccgact gatatagatt atcatgtaag aaagccaagc gcaagggagt
      781 atgatgattg ctgcaatgaa ttttggaatg taacacctta tgttattaaa ggattgtgcc
      841 gtaaggaaat tttatttgct attgatcatt ttaatcagat tgttcgccat gagctgctga
      901 gaatgatatc atggaaggtc ggcatcgaaa caggctttaa atgaagtgta ggcaagaact
      961 ataagtttat tgaaaggtat atatccgagg atttgtggga gaaacttttg tccacctacc
     1021 ggatggattc ctatgaaaac atatgggaag cattatttct atgccatcaa ttgttcaggg
     1081 cggtatccgg tgaggtggcg gaaaggcttc attatgccta tccggagtat gataggaata
     1141 taacaaaata taccagggac atgtataaaa aatacactgg taaaaccggc tgcctggata
     1201 gcacatatgc cgctgatata gaagagaggc gggaacagtg attacagaaa tgaaagcagg
     1261 gcacctgaaa gatatcgata aacccagcga accatttgag gtgataggta agattatacc
     1321 gaggtatgaa aacgagaatt ggacctttac agaattactc tatgaagcgc catatttaaa
     1381 aagctaccaa gacgataaat gcgtcggaaa agttaaactg cgaaaaaatt ggaaccggta
     1441 cgcttatata gaagatatcg ccgtatgtaa ggatttcagg gggcaaggca taggcagcgc
     1501 gcttatcaat atatctatag aatgggcaaa gcataaaaac ttgcatggac taatgcttga
     1561 aacccaggac aataacctta tagcttgtaa attctatcat aattgtggtt tcaaaatcgg
     1621 ctccgtcgat actatgttat acgccaactt tgaaaaagct gttttctggt atttaaggtt
     1681 ttagaatgca aggaacagtg aattggagtt cgtcttgtta taattagctt cttggggtat
     1741 ctttaaatac tgtagaaaag aggaaggaaa taataaatgg ctaaaatgag aatatcaccg
     1801 gaattgaaaa aactgatcga aaaataccgc tgcgtaaaag atacggaagg aatgtctcct
     1861 gctaaggtat ataagctggt gggagaaaat gaaaacctat atttaaaaat gacggacagc
     1921 cggtataaag ggaccaccta tgatgtggaa cgggaaaagg acatgatgct atggctggaa
     1981 ggaaagctgc ctgttccaaa ggtcctgcac tttgaacggc atgatggctg gagcaatctg
     2041 ctcatgagtg aggccgatgg cgtcctttgc tcggaagagt atgaagatga acaaagccct
     2101 gaaaagatta tcgagctgta tgcggagtgc atcaggctct ttcactccat cgacatatcg
     2161 gattgtccct atacgaatag cttagacagc cgcttagccg aattggatta cttactgaat
     2221 aacgatctgg ccgatgtgga ttgcgaaaac tgggaagaag acactccatt taaagatccg
     2281 cgcgagctgt atgatttttt aaagacggaa aagcccgaag aggaacttgt cttttcccac
     2341 ggcgacctgg gagacagcaa catctttgtg aaagatggca aagtaagtgg ctttattgat
     2401 cttgggagaa gcggcagggc ggacaagtgg tatgacattg ccttctgcgt ccggtcgatc
     2461 agggaggata tcggggaaga acagtatgtc gagctatttt ttgacttact ggggatcaag
     2521 cctgattggg agaaaataaa atattatatt ttactggatg aattgtttta gtacctagat
     2581 ttagatgtct aaaaagcttt aactacaagc tttttagaca tctaatcttt tctgaagtac
     2641 atccgcaact gtccatactc tgatgtttta tatcttttct aaaagttcgc tagatagagt
     2701 tctatattag agatgtaaag agttttggtg aagaggtttg tgagtatggc ttttataacc
     2761 agggtgcaat gagaagcact aacagcagct agcttaagaa cgcataggat atacttttta
     2821 tggaagtcac agaggaggaa taaaatttga acaggattaa cagagtaacc tctattctta
     2881 ttcagctgca atcaaaaaaa taattcctgc caaagaaatt gcacagcgat ttaatataag
     2941 cttaaggaca gtttacagag atatccggac acttgaagaa gccggaatac caattggatc
     3001 tgaggccgga aaaggatatt ttcttgtaga gggcttccta cttctgccgg taatgtttac
     3061 agcggcggaa gtgggtgcat tgattacagc agggaaattt ttaaattgcc atggagatga
     3121 atcatttata aaggattttg attcagctat gtataaaatc aaatctattt tgaagcatgg
     3181 tgaaaaaaac tatgcacagg agttggagaa cagtattaac gtgtacagca catctggaca
     3241 gaaaaataca ttggcggata acgttattgc agcaattcag actgcaatct gcaataaaag
     3301 ggtaatatca attcaatatc ctgcatcagg agggcaagaa ccggaaagca gaatgataga
     3361 gcctatatca ctggggtttt atgaacagaa ctggtactta atcggttttg caggctaaga
     3421 aatgaatata ggaattttcg tgtggatcgg attaaaagca tttgcataga agaagagctc
     3481 tgtcaaagcc atgatggctc tttggaacaa atattaaaac aaatgctggt tctgttgcaa
     3541 agtaaaaaaa tatagctaac cactaattta tcatgtcagt gttcgcttaa cttgctagca
     3601 tgatgctaat ttcgtggcat ggcgaaaatc cgtagatctg aagagacctg cggttctttt
     3661 tatatagagc gtaaatacac tcaatacctt ttaaagtatt ctttgctgta ttgatacttt
     3721 gataccttgt ctttcttact ttaatatgac ggtgatcttg ctcaatgagg ttattcagat
     3781 atttcgatgt acaatggcag tcaggtttaa gtttaaaagc tttaattact ttaaccattg
     3841 ctaccttcgt tgaaggtgcc tgatctgtaa ttaccttttg aggtttacca aattgtttaa
     3901 tgagacgttt gataaacgca tatgctgaat gattatctcg ttgcttacgc aaccaaatat
     3961 ctaatgtatg tccctctgca tcaatggcac gatataaata gctccatttt ccttttattt
     4021 tgatgtacgt ctcatcaata cgccatttgt aataagcttt tttatgcttt ttcttccaaa
     4081 tttgatataa aattggggca tattcttgaa cccaacggta gaccgttgaa tgatgaacgt
     4141 ttacaccacg ttcccttaat atttcagata tatcacgata actcaatgca tatcttagat
     4201 agtagccaac agctacagtg ataacatcct tgttaaattg tttatatctg aaatagttca
     4261 tacagaagac tcctttttgt taaaattata ctataaattc aactttgcaa cagaacctca
     4321 tttactatat gggcacctct ttcattatta atacaaagct ttgtatctcc gatattaggc
     4381 aaaggtgtaa acgaattagg tgatactata ggattcaaca ttatattaat cgtttcttta
     4441 ataatgatta tcttcttatt ttttataaat cgtagtaaaa atatctccta tgattatata
     4501 aaagttcaaa gaggtgaagc caatgaataa attagaaaaa tggtctttgg tatttattat
     4561 ttttacattt ctctcttcat tagcactttt atatttcaaa tataatttta gttcggttat
     4621 gccagtccta agtctttcta ttttaactat actaatattg ttgacgagta ttattactgt
     4681 agtttcagtt aatgatgaag atacttaaaa cgttcattag tgaaacaggt attatattaa
     4741 aaaagcgtac gaatttgtac gcttttttct tgtgttatta ttaaaatctc ataacaggaa
     4801 aatattatga gattttagac gctgtcagaa cgtctctttt acatcgagtg acattgaatc
     4861 aaagtctttg tatgttaatg atatataaaa ttatttagta gattcattat agtaagctag
     4921 attagttgct ctacttgttt ttattctctt ttgcctctaa tttattgaga taacgataaa
     4981 tagttgtacg tgaaacttgc cactgctctg caattgtttt aattggcgta ccattatcat
     5041 aaagtgtctt aagtaagttt aaatcttgtt tatttaattt ttcaggtcta cctccatatc
     5101 ggcctctagc acgtgctgca attcgaccgg ctgatgatcg ctctaaaatt aaattacgtt
     5161 caaactctgc aaatgctgcg aataaatgaa ataataattg tcctgtagaa cttgatttat
     5221 ccatcgttat attttcttct aaactatgaa aactcacacc tcgttcgtta agttcattaa
     5281 ctaacgtgat taaatcctcc atgttccgtc ctagtctatc taatctccaa acaacaatcg
     5341 tatctcctga cctcgcaaat tcaattgctt tatctaaacc aggtcgctta ctttttgaac
     5401 cactcatatg gtcattaaat atcttttcac aaccatatgt atttaatcga tcctcctgta
     5461 aattcaaatt ttgtaatcca gttgaaactc ttgcataacc tattttcaaa atacagacct
     5521 cctatataca cctttagtgt accataactt gattacgagg tcttttgtga acatagattt
     5581 tttgttgggt ttttgaacac ataattctat gtaatactta cttatttaga caaaaaacaa
     5641 gagtgtacag aaaatggtta ttttctggac actctcatct ttaataatat attttaaatg
     5701 tcattaacaa aactaattta ataagagtca agtatggttt acatatgtat tatgtttgaa
     5761 acatacctct aattactttt tactaatatc atttaaaatg tctcgcaatt cttcaatttc
     5821 tttgttattt aattcttcat ttttcgcaaa attcagcact aaacttttca tatcccctcc
     5881 atacagttta ttaagaaagg ttttagcagt tttcatttta atatcgtctt ctttaatatt
     5941 tgatgagtaa aaataaatat tttctgattt gtatcgtttt ataatctctt ttttatatag
     6001 tcttgtgatt aatgttctaa tcgttttatc actaacttct ttatattttt gaatttcaac
     6061 tacaatttca ttagctgata ctgatttttt atcccatatt atattcataa catcccattc
     6121 agccatagat atttcaactt gcttattggt catttaaaac acccattcct tttaatattt
     6181 tttcacttat taattcagca tttttcccag acgggtttcc atctgataaa tgtgtagcaa
     6241 aataatactt atcatgattt gtaattacgt aacctacaaa ccacccatta ttatacttcc
     6301 cgtttactat acctgtacct gttttcccat acagttcata cttttcattt ttcttaatca
     6361 ataatgaaga agataattga ttctttgctt ttttactaaa atggttattt tgttccatca
     6421 tatttttaaa aactattact tgttcaagat tagatatttt caaactatct tccatccaat
     6481 agcttttata acttcccaaa ttttcattac cataatttaa ttgcttgagt tgagccgcag
     6541 tatagttctt tggtatttga ttactaatac gttcgaagta ccaattaact gaattttgca
     6601 ttgctgtatt taaatcttgt tccttattcc aagactcgaa aagataatgt ttatgattcc
     6661 atgacatacg tgaattttta tcacttataa tatgacggtc aagtccaaac agtgctaaat
     6721 aaattttgta agttgaatca ggagaatatc tttttctact ttctttttca ttataaatat
     6781 agtatttgtc tttcttcatg ctgtacataa cgaaagatcc actatttgaa ccaaaatttt
     6841 tactttcatc taaaatttgg taatcgcttt gtaagggctt tttataatta taatcagtta
     6901 aggattgccc cattaaaaac tggctttgaa ttatcatgat aaaaaaagta aaaatacaaa
     6961 taaaaattag aattaatttt gactgctttt tcagatcggc ttcttttata ttaattaatc
     7021 tacttttgag taatgatttt ttaccattaa atgaatggct taatatattt ttgttggaaa
     7081 atggggtttt taatacggag tccataatag attccgcata agttttaaat tcatttttgt
     7141 taatattatt aaggacaaat ctatcggctt ctacttcatt gtcatgaatt atctttcttt
     7201 ttacaatatg tactaatgga ttgtaactca taataataga gaagatatta aagataatta
     7261 aatgtaaagt atctctattt ttagcatgag catattcatg cagtattata tattttagtc
     7321 ttttatcaat tacactttta aaatatgaac taggaatcaa aataatatat ttcccatacc
     7381 aaaaagttat tggagattga atagcctctg cttttcgaat cacaatattt tttttatatt
     7441 gatggttgaa aagtatcgta tctattttat ttttttcatt ttcgtttaga taaagtgact
     7501 gtttctttaa atatttaaga tataataagg ctttcaaaaa tttaaaactt aaaataataa
     7561 ctaaaactat ccaaataact gtgcagatat tatcaattga atcccaatta aacttatgga
     7621 tatctgttgt gaactcttga ataggtttgg tggtatttat gttatggttc aaatcgtgtg
     7681 acttactttc aactgtgggc gcttgattat tcacattatt aaattttata aaagagaatt
     7741 taattgggat aaaaggaatt aatccagcaa gcatagttag ataccaaact ttataattta
     7801 aactataatt aaaatagcgt tttaatatgt acctaaaaaa tactaacaat agaaatataa
     7861 aacaaaagct tactacgctc attattagta atttagccat tttgacacct tctttcaaat
     7921 atttataata aacaattgac atcaatatta caattgtaat attattgatt tataaaaatt
     7981 acaactgtaa tatcggaggg tttattttga aaaagttaat atttttaatt gtaattgctt
     8041 tagttttaag tgcatgtaat tcaaacagtt cacatgccaa agagttaaat gatttagaaa
     8101 aaaaatataa tgctcatatt ggtgtttatg ctttaaatac taaaagtggt aaggaagtaa
     8161 aatttaattc agataagaga tttgcctatg cttcgacttc aaaagcgata aatagtgcta
     8221 ttttgttaga acaagtacct tataataagt taaataaaaa agtacatatt aacaaagatg
     8281 atatagttgc ttattctcct attttagaaa aatatgtagg aaaagatatc actttaaaag
     8341 aacttattga ggcttcaatg acatatagtg ataatacagc aaacaataaa attataaaag
     8401 aaatcggtgg aatcaaaaaa gttaaacaac gtctaaaaga actaggagat aaagtaacaa
     8461 atccagttag atatgagata gaattaaatt actattcacc aaagagcaaa aaagatactt
     8521 caacgcctgc tgctttcggc aagactttaa ataaacttat cgcaaatgga aaattaagca
     8581 aaaaaaataa aaatttctta cttgatttaa tgtttaataa taaaaacgga gacactttaa
     8641 ttaaagatgg tgttccaaaa gactataagg ttgctgataa aagtggtcaa gcaataacat
     8701 atgcttctag aaatgatgtt gcttttgttt atcctaaggg ccaatctgaa cctattgttt
     8761 tagtcatttt tacgaataaa gacaataaaa gtgataagcc aaatgataag ttgataagtg
     8821 aaaccgccaa gagtgtaatg aaggaatttt aatattctaa atgcataata aatactgata
     8881 acatcttata gtttgtatta tattttgtat tatcgttgac atgtataatt ttgatatcaa
     8941 aaactgattt tccctttatt attttcgaga tttattttct taattctctt taacaaacta
     9001 gaaatattgt atatacaaaa aatcataaat aatagatgaa tagtttaatt ataggtgttc
     9061 atcaatcgaa aaagcaacgt atcttattta aagtgcgttg cttttttctc atttataagg
     9121 ttaaataatt ctcatatatc aagcaaagtg acaatagcat tttacaagta ttttttattg
     9181 ttcgattagg gtaaacctaa ataatacata aattatatta caatatgttt attatagagg
     9241 ctaaagtatc ttagaaattt ggatagtagg tttttcggga ataaaagtat agttggcttt
     9301 aatatataat taagctaagc tatcatttat atttactcga ttataattcg cacttcaact
     9361 tttttataac gtaaaaatta aaacgtagtt ttatttatct ttagtaatat ctttttaaac
     9421 actacagttt cttcattagt taaattagcg aagtaatgat tattaagttg ataggctttc
     9481 ttttctaatg ttggccataa gtcttttgct ttatttgtac tgtttattag cacagttctt
     9541 ctattttcat tatcagtttg acgtgttatt agatcctttt tggacatctt atctaatatt
     9601 ccagatattg ttgaaggttc taaatttaaa gtattaccaa tcgctttagg tgtattcaaa
     9661 ttactattaa tcaagcaatt caaaacacca tattctgctg gagtaatatt atagggactt
     9721 aataaacttt taaaatgttt aaaaactcta ttctgagaag tactcaacaa ataatttata
     9781 caattatcta attccacaac taaaacctct cttaaatcat tagtattgac tcgcttatca
     9841 tatcatgata agttttgtag gaaaatagtt ttgcaacaaa aacatacttc tacaaaacaa
     9901 ttgtgaaaga aggctaataa atgttcaatg cggtagtagt gagaaaaagt gcatcaaatg
     9961 ttagttataa agtagaaaaa gttgatgaat ctcatttatc gaagggtgat gtattagtaa
    10021 aagtggtata ctcttcaata aattataagg atatgctagc tttacaatat aaaggcggtg
    10081 taattagaga ttatcctatg attcctggta tagattttgc aggtattgtt gaatcaagtt
    10141 cgaatgataa gtttaaagaa ggcgataatg tattagttac tggttatgat gttggcgtga
    10201 cacatacagg tggattttca gaatatgcac aagtgcctgg agagtggatt gttcctattc
    10261 cccaagaaat gtctattaaa gagtctatgg tatatggcac agccggtttt acggcagcat
    10321 tatcaatttt tgaactagaa aaatatggaa tgaatatcaa atcacaacct gaaattttag
    10381 tgtctggggc tacaggtggt gtgggcagtg ttgctataca aattttacat aaaattggat
    10441 atgaaaatat cactgctatc gtaagaaaag aaaagcaaat agaaatcgca aaaaaattag
    10501 gtgcaaaaca agtaataata attgaagatg ataataaacc gcttaaaaaa ggtatttttg
    10561 attatttctt agatacagtg gggagtaatg taacattata cggtttaaaa cgtctaaatt
    10621 atcaaggtgt tgctactgta tgtggaaatg tagcaggaaa ttcacttaac gctaatatat
    10681 taccgtttat tcttagaggt attaaattaa ttggcattga ttctgtatat gttgatcata
    10741 atatccgtga agatatatgg agtaagttag caaatgaatg gaatatagga aattcacttc
    10801 tatacaatga aattggattt gaagaattct ataaaacgat agatcagctt ttaaaaggac
    10861 aacatttagg aagaactatt ttaaaagtat aagtgtgagt attcattaat acatttacta
    10921 ttaattcaat cattttgcat ttctctacta accagtgtta taatttatat aacgaaaatg
    10981 attaacaatt aatgcaccaa tccccacact attgcagtag tgtggggatt ttttcgatgc
    11041 tggcttataa agtcgcctat taattatttg ttgcgtttac taagccaata agtataatac
    11101 gcaacagcac agccactgat gactggtgct atgatgtgaa cgaaaatgat tagcaaagta
    11161 atgcacctcc tctcttcgtc aattgacgcc tgagagatag gcgactctat tattatacca
    11221 tctgtgaata tacaagcata tctacttccg ataagtcgtc ttatgttata taactttgtt
    11281 ttttatagta tcaagacaag aagaaactcg tttcaaaaac cctcatgatt tttagagaaa
    11341 aactctctta tttcatcgtc tttaataaaa taatatgcca tctttccatc tttataaaaa
    11401 tcaagtacct catttttata taaaagcctt aaatgatgtg aagttgaagc aacactcatt
    11461 ttcaatatca aagaaatatc acaaacacac aactcatctt ctttaatcaa agataatatg
    11521 attttcaatt tcttctcatc acaaattttt tctaaaatgt taagtaattt cttagattta
    11581 tcatcttcta aaaaacttaa agcattgtta actttatcct catgtacaca gatcacatca
    11641 caagtatttt cataactcat ataaaatcac accctaaatt aaaatataaa tcctaaaatt
    11701 gtttgaatag tgtcattttc aataataata aataaaccta aagctatata aataatagcc
    11761 ataatccaac gactaaattt ctcaacaatt tctccaattc ctggaatatt agctaatttt
    11821 tgtgcagtaa acaccaagaa gaaaattaaa attaaaaaga caaacagagt aagtaataaa
    11881 ttagtaacac ttaatgtcac aaaatacgga acaaataaac caatattatc ggcgccacaa
    11941 cttgctatcg taacaattgc aaccgtacca actaatttag acaatccttt ttcattcaat
    12001 tcttttttag ctctcttttc tccttcacaa tcatcataaa tagccacttt aattccaaga
    12061 taaattggta ttaaacccaa taaacctaat atccactttt ctggaacata atttaataca
    12121 aaagctaaaa acaaactaac taatattaaa ataatagacc ctaaatattg accaacataa
    12181 atatctctat attcttttct agtctttgct ctagcaaaaa atattaataa aattactaat
    12241 aaatcaactg ctgtagcaat ataaagaaca gcagcagcaa caaccgtttg aatcataata
    12301 cacctcattc aaaaatattt ttgaatgtat tataacttat atttttaaat aatcataggt
    12361 gctttattcc aattgcttta ttgacgttga gcctcggaac ccttaacaat cccaaaactt
    12421 gtcgaatggt cggcttaata gctcacgcta tgccgacatt cgtctgcaag tttagttaag
    12481 ggttcttctc aacatcaata aattttttcg gcataaatgc gtgtctatgc gtagacatgg
    12541 agacacttca gaattatgga gtgattacat gagtttaact atttttcttt attcagtttt
    12601 aggaagttta ttagcaaatt atatctacga aaaatcttca aaataaataa ctttttcggt
    12661 tctactttgt acactttatc tacctggtag acctaattgt tattgcttta caggtctaaa
    12721 attcgtcgtt ataatctagt taaatcccgt aagggcgcac ttatacgtcg gataaatcga
    12781 catgtgcaaa aacgtaatcg accttcgtcg atttttttat ttcaaaatta aagaaacggc
    12841 ttgagatatt ccgagcagtt ataaaaatta atttgcgttg aatattgcta ctacattctt
    12901 gaaaaagtga tgtagattta tagcccataa cttttttgaa ttacatcgac gatacggcgt
    12961 cgaaagaaaa ataaatagac cgtatgaaag aaaaagctac ctcactttat ctggggtagc
    13021 ttttattttt tatgccctta ttttgaattt taagagggca ttttaaagat ttaggggtga
    13081 ttcatatagt tttatatcta aaacttatat atgcttttaa aacgcaaata tgagccaaat
    13141 aaatatatgc tattttcaaa aacaaaaatt tgagcaaaaa caataactat ttttagacac
    13201 tgcccattta catgcaaatt aaaaattagc ataaaattct ttaaaacttc cccacgtttt
    13261 tctaaattcc tgtagggcgt ttttatcaaa aatcaagaca agaagaaact cgttcacact
    13321 cgtttcaaaa aaacaagaaa tctaatctat acacctaccg ttttccaacc ccctcaaagc
    13381 atacaaatta aaaacaaaat tattcataat cttactttct tttaacaaaa acataaaaac
    13441 cataaataga caaattaact atcaaaggca ataaacagta taaaaaaacc acgaataaat
    13501 cttcatcaac atctaaaata aaaaagaata aaacaattaa caaaatacta attaacaaac
    13561 ctaaaagtgg caaacttttt atatattttt ctaaattttc attcataaaa tagactcctt
    13621 tcaaaaatat gtttataaat atattaaaat aaatattaat tttataaagc gcttacttat
    13681 acaattaaaa tatcttatta tcttggaggt atcaaatgaa aattataaaa ttattttcaa
    13741 taatttcctt gttcctactg gtatttagcg cgaatttttc taatgcttac gcaaatgaag
    13801 aacaaaaaag ttctttacta gaaaatcaaa aagaaaaatt gaaaagcaaa aacatcgaag
    13861 tatcacaaat gaccaagaaa gaaataagtt ttctagaaca attgcaaaat aaaaatgaag
    13921 atatgcaaaa attcgaaaag caaatgaaaa aagaaggatt taaaaaaata aagctagaag
    13981 acaaaaattc taaattaaaa tatctagcta cagaagcaaa tgataaaaat gcatatggct
    14041 acatagctaa taacgcttat aaaaatgaaa aaacaaaaga aattgtagtt tctgaaacaa
    14101 tatatgataa ctacaacaaa aaaatcacaa aattcattgc cgaaaaaaga agtatgactg
    14161 aaaacaaaga gggaaaaata cttattaaca aaaattacgt tgaatataag gctgaaaaag
    14221 ttgataaaaa cagaccggta acatatgcag gattcaaatg gaacggcaaa gcattcgctt
    14281 gtagtatggc tggactttat gcatgtgctc actactgtgg agtatgggca atcgtaaatc
    14341 caatagccgg cggtgtatgt gaagcagttt gcggaactgc atttgcagct ggatgctctg
    14401 taggttgatt ttattccaat tgttttattg acgttgagcc tcggaaccct taacaatccc
    14461 aaaacttgtc gaatggtcgg cttaatagct cacgctatgc cgacattcgt ctgcaagttt
    14521 agttaagggt tcttctcaac atcaataaat tttttcggca taaatacgat gttccttatt
    14581 tatcctcata aaaaacaata gctgaaatat ataaccaatt actgtgtgtt tgaatttcta
    14641 atacatgaat atcattcttt aaaaacctat taacttgttt atctaattga cgatgagtaa
    14701 aagtagcgaa agttttaatc ttcatgatat ctctcctttt ataaaaatag caatccttat
    14761 tacaatatta aacactttta ttttggattt taagaggcat tttgaagact tagaggcaaa
    14821 tcatataggt tttgtactta aaaatctata cagtctctta aaacgcaaat atgagccaaa
    14881 taaatatatg gtaatttcac aaacaaaaat ttcagcaaaa ccagtgacta attttttaac
    14941 actgcccatt tacatgcaaa ttaaaaatta gcataaaatc ctttaaaact tccacatgtt
    15001 tttctaaatt cctgcagggc gttttttatc aaaaatcgag aatttttaat ttttctctaa
    15061 aaactccgta agagcataag gagaatttgc tatcattcaa aaatgatagg tctggcaaag
    15121 ccagaaattc caggggtttt aaggtatttt aaagtgatat catacaaagc tgtactgtct
    15181 tatttttgtg acacaatata ttgcgtttgt cttatttttg tgacactaca tacagcattt
    15241 gtcacaaaaa taagacagta cttttttata aaaaatcaac aaaaaagaca ttagtcaaca
    15301 ctaatgtctt aaataataat tttgcttttc gaaattccaa attgcggtaa ttgaatgtgc
    15361 tttttcttct tcgtctgttg ttttatcttc atcacttgca ttaatcaaat taccatcttc
    15421 gacatcgtct aagtttaaaa ttttatgctt ttgtttaagc aatccaccat aacttaacat
    15481 acgttttcga tacaaacctt tttctaaatc acttacaatt tcttgatttt tttcgtcgtc
    15541 atcagttaaa aagtcagatg atttaacgga atattttgat gtctcttcga gtgttataaa
    15601 atcatttgaa ttattgatta aagatattat attgtttcat gtttttacgg cgcatataaa
    15661 gggcatgtgt ttcttcaagt tcagttagaa ttgtttgcat taaataagct tgcattgact
    15721 tgattgtttc cttttggcct ttaactcccc tatcatgtat agctttttta agtcttttta
    15781 aagaagttaa tatttcatcc tcaatgtcct ctaacatgta atgcatatct tcatgccttg
    15841 aattaaatga tttttttgct ttaagaataa cagcctttat gatttctaaa tctctataat
    15901 catattttaa taaataatta gttagttgtt ctgggaattc ttgcaatagc atttctttat
    15961 catcaaaatt atgtgtaaat tgatttgaat gatttgaatg attactaatt tcatttttgt
    16021 actttatatc attcaagtca ttcatatcat tattctcagt atcattaaag tcaatgtcat
    16081 taaagtcagt atcattagtg ttcgattttc gaacttctgg acgttcgatt ttcgaacttc
    16141 tggaagttcg attttcgaac ttctggacgt tcgattttcg aacttccttc tcgccgtaag
    16201 gttcaacatc gttttcttct ttttctattt tgtaaatatc acgttctgtg acaataggtt
    16261 tcattaaata tagaatattt ggtttattta aaccacgtcg tttttgaatg agtagaccat
    16321 cgttttctaa cccttttttt atttttgtta acttttcttt tttacaattt aagatttcca
    16381 ttagcttttc atttgaataa acaaagtaaa tgttaccatc ttcatcaacc cagctatttt
    16441 taatagataa atttaagcga tcacgtaaga tagcataggc tattttcata tcattagtta
    16501 gatttttata attttcactg gtaaagaata ctttagggat ttgataaaat ctttctttgt
    16561 aattttcttg cactgtaaaa tattgatttt gcatgacaaa aaacctcttt ccatatttta
    16621 gtttggtaag aggtaataaa acgtttttat ttagctttac atttatttaa tgatttaggt
    16681 gcttgcacta agatattatt cattatataa tacaagtatc gaaaattata taaataaaca
    16741 gtttctaaac gttttattac caaaccccga ctattaccag tagttggggt ttttgttata
    16801 ttaagtttat tatagcactt taaataaact tataaaaggg aaaatatagc tttatcaagg
    16861 gtttataaac ccttgataaa tatcataaac ctttcataaa cccttgataa aaaggttgat
    16921 ggatgtttat ttttatttat taatcacttt attattaagc attataagct tataatattt
    16981 tatcaagggt ttataaacat tttataaagg gttgatgata tgaaaagtgt gaaaaagttg
    17041 agtgaagaat taggggttag taagcaaacg atttttaata atattaagcg attgaatata
    17101 gagacaataa aacaggaaaa cacttcgttt attaaagaag ataccgatat agaaaaaatc
    17161 attcaaagag taaatgaaaa taaaaagaaa tatggttttg aaagtactac tgaagacaaa
    17221 caaaaaaaag ggtcggataa tattaatttt gaatcgaaaa gcgatgctca aatagtagaa
    17281 atccttaaaa atcagattga tactttaaat aatcaaattg aaaaacaaga aagtcgtcat
    17341 gaaacaacaa ttgaatttta cagaaaagag ttgcaagaaa gatcaaaatt gcttgaaaat
    17401 cagcaagttc tggcattaga gagtaataaa aagattcaaa aattagaaaa tcaattagaa
    17461 aaagaaaaac accttaatta tccctttgat acatctacta acactagaca aaacgttgat
    17521 gcacaagaaa aaacatatac tactaatcct gtaaatatta acagagatca ggaagaaact
    17581 aaagaaacag agattcaata taaggatata tctggaagtc aaagcgacga aagtacacaa
    17641 ggtgaagaag caaaaaaaga agacgttcca gctaatctaa atgacaatga tagtgatata
    17701 gaagaaaaga gtgaagaaac ggaacctaaa aaggggtttt ggagtcgttt gtttggtagc
    17761 taaaataatt gattaggcac taaaagttat aaaattttag tgtcttttat atagtgagaa
    17821 cttctggtaa tcatcgatta tgtaaactaa agtatttcaa ataattaact gtattaatac
    17881 tctcatcatg attgcgttat aaacgttcgt tattgagaca aaatttaata gtactactac
    17941 acaaaaagag agtgcgaatt cgcactctct ttttgtgata aatgaatggt taagaaaata
    18001 attcatccac agttgtatca aacaatcttg ccaacttaaa tgctaatgtc aatgtaggat
    18061 catatttatt gttttctatt gcattaatag tttgcctaga cacttttaat tctttactta
    18121 aagtttcttg agaaattcct ttttgttttc tatattctct aattctattt ttcattaatt
    18181 taacctttag atgtatattt tttatttgta gtatagtaat taaacagcat aagaaatagt
    18241 gctacaatta taaagaaaat ttctggatat tgagaaaacc aagatccttc aatacttggt
    18301 gacaaacctg taaatttaag cactagtgta aataacatac aatatacaat ccaaataaaa
    18361 cttttagcca gtatttcaat aaacatttta cgttgtcttt catcgtatcg atcttgttgt
    18421 ccttttttat ctaatgtttc tgaaggtaaa tatttgttag ttatagccgt ccataaacaa
    18481 gaaaaaatta aaataataat aaaaggaatt aaattcatta taacacctca taaatgtaaa
    18541 aagtatttga catttatgag tgtaaatatt tttgatacaa atgtcaaata ctttttacat
    18601 tataatatat tttaaaacac cttattagta aaacaattac tatatagaaa gctgcgaact
    18661 cgtactcttt tttcttgtat aattattaaa atctcaattc aataatatgt tatggaattt
    18721 gagacactgt gagagacgct catttgcatt gacaatcaat ttatcaagat aatcccttat
    18781 catgtttaat tctataaact gtttgtcttg tgatattaac ttctttcgca atcttactaa
    18841 tcgctttgcc ttcttctaac atttccacca cgcgatgata aataacacgt ttctgtgggt
    18901 ctttagcatt tggtgaataa agtaaagggc gccctttata tacgcctttt tccttcgcaa
    18961 cttgaatccc ttgcgcttgt cgacgtttac tttcatttct ctcttgttct gaaaccattg
    19021 ctaatatttg aatgattaaa tctttcataa acttatccag taatggattg ccaattactt
    19081 cattcatcat aggtaagctg gtaatcatta actgaacgtc tttttctttt aaataattca
    19141 cagtttcaat aatttcatca tagttacgtc ctaaacgatc aatagattcc acaacgaatc
    19201 gatctcccat tctgacaaaa ttgagtgctt cttgaaatac aggtctattt tccactgact
    19261 ttcccgactg tttctctgta aagattttct ccacaccaaa cgtctttaaa ttatccaatt
    19321 gtctttctaa attttgatct atcgatgata ctctcgcata acctataatc attcatcttc
    19381 actccataat aaatatacac cctaatcata cgttttaatt gttataattt caacaattct
    19441 ttttgtatgg ttagggtgta ctcaaagtgt acatatctat aattaaaact tactaaaaat
    19501 aaatatagat tttttctttg taacagaacc gttcatttga aggtcatctc tatcataaat
    19561 atttaaatta actaaaaatt ttaatcatct gtttaatact tatgaaatgt atttacggta
    19621 ggtattaaaa ttgatgaaat ttatataagt gctttcaatg aaaatgaccg tttatttatc
    19681 ctcctgattt aaggagttag aaatttcgaa aacgattctt tccatttgtt gcatttgttc
    19741 catgtccaga tatttaatac attatagaaa accaaagacc atcactaatt aaacgcagtt
    19801 ttaaaatttc atcaggattg ccttcgtctt taaaatgggc ctcttttaat ataagttcta
    19861 ctctttcata cctaactctt tcaatgccat cgtttcatac gccgattctc ctgattccat
    19921 agcaaactca gcgataaaca ttgggaatac tgcattgagt tctattatat gctctttcat
    19981 tcgtggccat atttcacctc cagctttacc gtatgctgtt ataagttgct ctaatccttc
    20041 gtcgtcgaat acacgatggt gtcctataaa gtccattgat gggtcggagt gggttgcttc
    20101 agtccagtct atgagacctg tgacgtttgc ttggttatct accattatat gtcctggatg
    20161 taagtcccca tgtatcatgg tcgcatgtcg aggccatagt tcgtcgtttt ctaaccattg
    20221 tttccatctg ttccataatt catctgatac gccataagtt tctttaactt tattcattct
    20281 tctttgaaag tcatttttta tttcttgtat ggttttgata tttatatgct gaacgttaat
    20341 gttttcttct ggtatgttgt gtaaatctac gagtgtttca gctaatgtgt taataaagtt
    20401 ttctggtaat ggtttgtgtt caatttccca tacataattt tgtatttctg gatctattgt
    20461 ggctgcgggt ttacctgtaa gttttgggta agcaataagg tcttttgcat gtactttcca
    20521 cttcggtatt tcaaatgaaa cattcttctg taagaagtct accgtttgtt tttcgggttt
    20581 tgttcgttta taaacgtcag gtcttcttgg tagtctcaaa acccattcta ctccatgttt
    20641 atcttttcca aatgcaactt gaaaatcaag tcccgattca ttcaatgaga ttgtttgagg
    20701 ttggatgtgt aattgatatt tttctgcaca tttaataatt tcattatgtc gagtcatttt
    20761 attggatcct tatttctatt atatttttct tgtgaacgta ttttttatat tgatataaat
    20821 gaacctaata ttcaatataa attagtgtat agtttttaag ttatatcatg aagagattgt
    20881 cctgttaatt cccatttttt atctgataca tgtttaacaa accttgtatc atgtgatgta
    20941 aacaaaatga ttccaggata tttattcata aacatttcta atgcttctaa tgttttaata
    21001 tctaaaaaat tagttggttc atccaaaatt aacatattcg ctttcgttga aaataatact
    21061 gctaacgata atttcgttct ttccccacca ctcaaaacat tacaagaacg atcaagtgct
    21121 tcatttaaac ccaagttatt taaaatagct ctactgaatg attctgatga atccgtttca
    21181 tccattaaat attgcaataa tgaaacgtca cgcatgtctt cataagcaag ttgacgatag
    21241 tatgccattt gcactttagg agaacaatca attccctcta tttggtggta aatagcttca
    21301 agtaaagttg tcttacctac accatttgca cctacgagcg ctatattttt gccatatggt
    21361 atttggaatc gtacttgtgt tagcagtttt tgacttcctt taaccaatgt tagattttgt
    21421 gcaatgattg gataattatt atggatatca taaattttat tttgtgggaa attgaattca
    21481 tgataacttt gtggtttttc aacttcttcc aaatgttcca ttcttttttc aatatgctta
    21541 gcttgttttt gagcagcctt ctcaaccgtg cctttttgtt ttgatgcact taaacgatct
    21601 ggtgctatac ttttgttttt ttgttttgat gatgcttgtg ccatttgttg cgcttgattt
    21661 cgtttagctt tactggcttg ggacaatctt tgtttttcac ttatatactg ttcatattga
    21721 cgttgttgtt ctaactgttc ttgttcatat tgattttgat actgtgtgta attaccttta
    21781 aacactctta ttgtgccatc ttcttgtata tcccaaattg tgtcagcaat ttggtctata
    21841 agtgctctat catgacttac tataattaaa gtaccatagt aatattttaa aatatttttc
    21901 agataatctt taccaatttt atccaagtga tttgtaggtt catctaaaag taatatcgga
    21961 ctataatttg atatgacatt agctaattta tattttgctt tttcaccacc actcatactg
    22021 tcggttgtat gcataggtat atggagttca ctcattaaac taccgtctaa cgtgttaaaa
    22081 tcattttcca catccatgtt aagctgttca aaatattgaa tttcgccaac cgtttcaact
    22141 gttccagatt ctggttttgt tttttgagca atcatattta gtaatgtggt tttgccagta
    22201 ccattacccc caataagtgc tattttttca aattggtaag cgtaaagatg accgatgtta
    22261 agtgatcgta aatctgtcaa tttatgattg atttggttaa atttaattgt atattgttcc
    22321 atatttatac actccttgta tatttaaagg acgtgtacgc aaaaaaatga gacaggctac
    22381 tcccgtctca ttcacattac actttcaaac acttaaaaat ttattatgat gttttagtat
    22441 ttgaaagcgt ttattattcc tatcgaagga taaaaaatga cataagtcat cctatgagtg
    22501 tgtattgcgg acaagccttt ttgaattaat ttagttttgt attcaaaaag gtttatttga
    22561 gtctcataga agctgtcatt ttaatcctcc ttcatcgata aaatagtaat gttaatataa
    22621 cattttgttg gtttttttac aatatatctc taagtagaaa gattatataa caaaagtata
    22681 aaaatacaat tttagattga ttatacatct ccttaattta gagtgtactc ataaaatacg
    22741 gttctgttgc aaagttgaat ttataatata attttaacaa aaaggagtct tctgtatgaa
    22801 ctatttcaga tataaacaat ttaacaagga tgttatcact gtagccgttg gctactatct
    22861 aagatatgca ttgagctatc gtgatatatc tgaaatatta agagaacgtg gtgtaaacgt
    22921 tcatcattca acgatctacc gttgggttca agaatatgcc ccaattttat atcaaatttg
    22981 gaagaaaaag cataaaaaag cttat
//
