LOCUS       CP152329               32592 bp    DNA     circular BCT 29-APR-2024
DEFINITION  Staphylococcus aureus strain BSN135 plasmid pE2, complete sequence.
ACCESSION   CP152329
VERSION     CP152329.1
DBLINK      BioProject: PRJNA1048360
            BioSample: SAMN38637714
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 32592)
  AUTHORS   Berti,A.D., Gurdziel,K. and Liu,W.
  TITLE     Pre-publication release of Staphylococcus aureus str BSN135 whole
            genome sequence
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 32592)
  AUTHORS   Berti,A.D., Gurdziel,K. and Liu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2024) Pharmacy Practice, Wayne State University,
            259 Mack Ave, Detroit, MI 48201, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2024
            Assembly Method                   :: SPAdes v. FEB-2024
            Assembly Name                     :: BSN135
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: CP127720, CP080006
            Genome Coverage                   :: 213.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/23/2024 11:43:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,801
            CDSs (total)                      :: 2,722
            Genes (coding)                    :: 2,656
            CDSs (with protein)               :: 2,656
            Genes (RNA)                       :: 79
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 30 of 66
            Pseudo Genes (incomplete)         :: 33 of 66
            Pseudo Genes (internal stop)      :: 16 of 66
            Pseudo Genes (multiple problems)  :: 13 of 66
            ##Genome-Annotation-Data-END##
            Bacteria and source DNA available from Andrew D. Berti, Wayne State
            University, Detroit MI  USA.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..32592
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="BSN135"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pE2"
                     /geo_loc_name="USA: Detroit, MI"
                     /lat_lon="42.33 N 83.05 W"
                     /collection_date="2021-09-29"
                     /collected_by="Andrew D. Berti"
     gene            complement(join(32526..32592,1..608))
                     /locus_tag="UXR30_13830"
     CDS             complement(join(32526..32592,1..608))
                     /locus_tag="UXR30_13830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004803 - transposase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="XAE32927.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            complement(638..1864)
                     /gene="mobV"
                     /locus_tag="UXR30_13835"
     CDS             complement(638..1864)
                     /gene="mobV"
                     /locus_tag="UXR30_13835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016913210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_process:
                     GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MobV family relaxase"
                     /protein_id="XAE32928.1"
                     /translation="MSYSIVRVSKVKSGTNTTGIQKHVQRENNNYENEDIDHSKTYLNY
                     DLVNANKQNFNNLIDEKIEQNYTGKRKIRTDAIKHIDGLITSDNDFFDNQTPEDTKQFF
                     EYAKEFLEQEYGKDNLLYATVHMDEKTPHMHYGVVPITDDGRLSAKEVVGNKKALTAFQ
                     DRFNEHVKQRGYDLERGQSRQVTNAKHEQISQYKQKTEYHKQEYERESQKTDHIKQKND
                     KLMQEYQKSLNTLKKPINVPYEQETEKVGGLFSKEIQETGNVVISQKDFNEFQKQIKAA
                     QDISEDYEYIKSGRALDDKDKEIREKDDLLNKAVERIENADDNFNQLYENAKPLKENIE
                     IALKLLKILLKELERVLGRNTFAERVNKLTEDEPKLNGLAGNLDKKMNPELYSEQEQQQ
                     EGSVAKLNL"
                     /name="mobV"
     gene            complement(2053..3432)
                     /gene="tet(K)"
                     /locus_tag="UXR30_13840"
     ARG             complement(2057..3432)
                     /name="tet(K)"
                     /gene="tet(K)"
                     /gene_name="tetracycline efflux MFS transporter Tet(K)"
                     /tool="amrfinderplus"
                     /drug_class="TETRACYCLINE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(3594..4520)
                     /locus_tag="UXR30_13845"
     CDS             complement(3594..4520)
                     /locus_tag="UXR30_13845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000277654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0003916 - DNA topoisomerase activity [Evidence IEA];
                     GO_process: GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation factor domain-containing
                     protein"
                     /protein_id="XAE32941.1"
                     /translation="MFFTLQQNHHDLDNFSKTGYSNSRLDAHTVCISDPKLSFDAMTIV
                     GNLNRDNAQALSKFMSVEPQIRLWDILQTKFKAKALQEKVYIEYDKVKADSWDRRNMRI
                     EFNPNKLTRDEMIWLKQNIISYMEDDGFTRLDLAFDFEDDLSDYYAMSDKAVKKTIFYG
                     RNGKPETKYFGVRDSNRFIRIYNKKQERKDNADAEVMSEHLWRVEIELKRDMVDYWNDC
                     FSDLHILQPDWKTIQRTADRAIVFMLLSDEEEWGKLHRNSRTKYKNLIKEISPVDLTDL
                     MKSTLKANEKQLQKQIDFWQHEFKFWK"
                     /name="replication initiation factor domain-containing
                     protein"
     gene            complement(4554..5228)
                     /locus_tag="UXR30_13850"
     CDS             complement(4554..5228)
                     /locus_tag="UXR30_13850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004803 - transposase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="XAE32930.1"
                     /translation="MNHFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            complement(5508..6278)
                     /gene="aadD1"
                     /locus_tag="UXR30_13855"
     ARG             complement(5512..6278)
                     /name="aadD1"
                     /gene="aadD1"
                     /gene_name="aminoglycoside O-nucleotidyltransferase
                     ANT(4')-Ia"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(6438..6875)
                     /locus_tag="UXR30_13860"
     CDS             complement(6438..6875)
                     /locus_tag="UXR30_13860"
                     /inference="COORDINATES: protein motif:HMM:NF013603.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_process:
                     GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /protein_id="XAE32932.1"
                     /translation="MEPTYFKNTENYVNQKQWIQFWKKAMKLDYDPNVKVQMIRPKNKY
                     KSDIQSAIDETAKYPVKDTDFMTDDEEKNLKRLSDLEEGLHRKRLISYGGLLKEIHKKL
                     NLDDTEEGDLIHTDDDEKADEDGFSIIAMWNWERKNYFIKE"
                     /name="protein rep"
     gene            complement(7042..7401)
                     /locus_tag="UXR30_13865"
     CDS             complement(7042..7401)
                     /locus_tag="UXR30_13865"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="XAE32933.1"
                     /translation="MKKMLRISIFIIVVSIFIVFKYSYQIEGILEEYPNILKAFVALFT
                     LLTTVISLVIAYKSYDNSVKQQEKDKEEKNKQFEENSDRIINSLKSDLAKYTRKINVFR
                     LGYTNSGSVANLKII"
                     /name="hypothetical protein"
     gene            complement(7736..7831)
                     /locus_tag="UXR30_13870"
     CDS             complement(7736..7831)
                     /locus_tag="UXR30_13870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="XAE32934.1"
                     /translation="MSEIFVNIMTTAASGCLVALFAHWLRKRNDE"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(7985..8521)
                     /locus_tag="UXR30_13875"
     CDS             complement(7985..8521)
                     /locus_tag="UXR30_13875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="XAE32935.1"
                     /translation="MISNKLKSARLAKELTQSEVAKKLYVTRQTVSRWEQGKTLPNIYV
                     IQELSNLYDISLDELVVNTALENKEAKSMKNVNPFALFGAILFNVFLFSLIVIFFGGFL
                     LLSLFISLAMLFSPLILAIFVLTGVQEFNVIQLVMTVIFVVIGLLSIPLLKKVSVFLFK
                     FFKRYLKFNHKAIFY"
                     /name="helix-turn-helix domain-containing protein"
     gene            complement(10368..11303)
                     /locus_tag="UXR30_13880"
     CDS             complement(10368..11303)
                     /locus_tag="UXR30_13880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="XAE32936.1"
                     /translation="MPNFEKYNLSQVKTERFYQLPKYLFEDAYFKKMSAEAKIMYALLK
                     DRFELSIQNEWVDKNNNIYFIFSNKHLCEYLGYAEQKIIKLKKELISFNLLTQERVGLN
                     KPNRLYLLKPNYDIKASHSKELPNSQFQNNEFGSSRTVNLSGQELPNSQSNDTENNDTD
                     YIKTESNDTNDLNDNKLTFPSNHTNHSNHNNSNFNNEALKFQLLEELPQSIQRYLSNFS
                     VNEIKIIKPVLLKAKTSFNNSIDTYYLLEDMEIEILHVLKRFKAMLIQKNETVEAMQGY
                     LMKSLKSEFAEMHTLNKRRDHLPITSLFNQ"
                     /name="replication initiator protein A"
     gene            11743..12510
                     /locus_tag="UXR30_13885"
     CDS             11743..12510
                     /locus_tag="UXR30_13885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002489261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="XAE32937.1"
                     /translation="MRTIKMVADELGVTKQTIVNNAKSLNITFEKENGINYIDDNDYLK
                     IIEKITKKESTIQNKESVKKELFGENTAKSEKNIYNNSNSSETLKTKVNELEKQIEIFE
                     TRAKNDEKYIENLTKQLDQQNSNVNTLNKLLENQQILALESNKKIQKLESQLEEERQLN
                     YSFDTATNNRQNINPQEATFTEESQNINQQQTKRQPTEVNYKDIAEEKKNDSTDEGELT
                     KEDKFVEETKNDPDDNREVEPPKKGFWSRFFGN"
                     /name="DUF536 domain-containing protein"
     gene            complement(12733..12918)
                     /locus_tag="UXR30_13890"
     CDS             complement(12733..12918)
                     /locus_tag="UXR30_13890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="XAE32938.1"
                     /translation="MFGDQRQEATKYVIKEGYQDIYFLNKNGEWYYFEVRSVWRGKHII
                     RVKDGLLGWRKEIVTE"
                     /name="hypothetical protein"
     gene            13067..13138
                     /locus_tag="UXR30_13895"
     CDS             13067..13138
                     /locus_tag="UXR30_13895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="XAE32942.1"
                     /translation="MNEILVHIMTTAISGCLVTLFGY"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(13377..13718)
                     /locus_tag="UXR30_13900"
     CDS             complement(13377..13718)
                     /locus_tag="UXR30_13900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="XAE32939.1"
                     /translation="MKLAEAIKEQRELKGWSQEELANILKVSRQSVSKWESAKNYPSLD
                     ILIAMSDLFGISLEHLIKGDARFKKVILEGNYRESNRVPSIVDFLYDFWWLFFPVAGFL
                     VWAIHSFMG"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(13805..14665)
                     /locus_tag="UXR30_13905"
     CDS             complement(13805..14665)
                     /locus_tag="UXR30_13905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="XAE32940.1"
                     /translation="MTGETVVYKNEMNLVPLRRFTATEINLFFAMCNKLKEQDTNTLRL
                     SFDELKKLSNYSPETRNINRFANDLDNVYKKMLNLTIRYEDDDVIERFVLFNHYRIHKR
                     EQYLEISTSSNLKHILNSITNNFTKFELKEMTRLKSTYSKNMFRLLKQYKHTGYLKIHI
                     DDFKNRLDIPKSYRMTDINKNVFKPIIIELGSIFNNLTINKIKAKKGRKIEWIEFTFDA
                     EKRIHNKRQPQMSKIDKSRQYVRREKTPKWLEERSYEKQPQKDYDPQLEKEREDFLKQL
                     ELNWE"
                     /name="replication initiation protein"
     gene            complement(15049..15594)
                     /locus_tag="UXR30_13910"
     CDS             complement(15049..15594)
                     /locus_tag="UXR30_13910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001805533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase"
                     /protein_id="XAE32943.1"
                     /translation="MYEIKTKNVGGWFHKEKQETGNIVITKTDFEKYTKQIKAAQMILD
                     DYECIKSGKSLKKAEKQNESLVNELTSVHMENEKLVEEFNDLAQRYNYLLSENEKKDKE
                     LNYTLKLFNQVFKIIKSMMKEERYHTLINHIDNHLDNSKIREVMTIDNNDEQFFKKKYQ
                     AQEREIIFKEDREDGYTL"
                     /name="recombinase"
     gene            complement(15688..16317)
                     /gene="mobV"
                     /locus_tag="UXR30_13915"
                     /pseudo=""
     CDS             complement(15688..16317)
                     /gene="mobV"
                     /locus_tag="UXR30_13915"
                     /inference="COORDINATES: protein motif:HMM:NF013258.4"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MobV family relaxase"
                     /name="mobV"
     gene            complement(16555..17181)
                     /locus_tag="UXR30_13920"
     CDS             complement(16555..17181)
                     /locus_tag="UXR30_13920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="XAE32911.1"
                     /translation="MIKLENVFVKKGNKNILDGCNFNFEKGKSYALVGESGAGKSTLLN
                     IIAGFEDVSQGSIYIEDKLLKKKVDFYRYTLGYLFQNFALLENQTISQNLDLALKFKKN
                     KKDNMNLKKEVLKKVGLDLDIKRIVSSLSGGEQQRVALARLILKDPKIILADEPTGSLD
                     TKNGKIVIDLLLKLLDENKTMIVVTHDLELAKRFDVIVNISELRS"
                     /name="ABC transporter ATP-binding protein"
     gene            complement(17193..17504)
                     /locus_tag="UXR30_13925"
     CDS             complement(17193..17504)
                     /locus_tag="UXR30_13925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YxeA family protein"
                     /protein_id="XAE32912.1"
                     /translation="MKRTLIIVTIVLLIIILSLLLVRNEHLDRFNPLLKEKVSYAKVPK
                     DTQDYRNITVYSKNGEKKSYKLDFLGYDPTKEYVKVNHKGKYVRSIEYITKDIPSFLK"
                     /name="YxeA family protein"
     gene            complement(17508..19442)
                     /locus_tag="UXR30_13930"
     CDS             complement(17508..19442)
                     /locus_tag="UXR30_13930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001670421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="XAE32913.1"
                     /translation="MKKFKLFLDFSTLLLISGLLFLFFFKENEEIIPESSNILTISNWD
                     KSNSKSKVLDVIESGAKNQNIQIIKSVKDFDNKKEFFVFNSKRNNSDFIRNKTSLLTPS
                     DLLNREIKGKYYIIGEHFNVEELTSELKKAGLTSEVEYINRNILFFELVIDNDLLVPFI
                     FLGVLYLLYFLYDRGYNLKFYAIQKLHGFSTTRIIFHNIHIKIIYWLVLTAIFFIANIL
                     IIHIANLELDFLMFIRRFIVLLFVFACITTLLWLISYSLLLKLSIPLILKGKKGYKFSI
                     FMGTFTKCIMVLILSFLLAQNLNAYTKLKNIYDSEKIWQKLDNYYTLEISPNIRNSEEK
                     QILETNIYNLIKKSEQLGGLLLKNNNIANPDKNNYIPENGNVFFINNNFLNFYKNINHD
                     FKMIDNHSDKINVFIPPRLQYQKSEIQKNHQGWIDFQKQQNKKVDVQVLSKNVSVFSFD
                     RTTNLKFGYLDSPIVMLLTLDDLTGDFYLAAVSQGGYLFKDLDTLKQLLKDNHLEEEIS
                     GITNYKDSVLNELNETKTKMIITIVTIIINVFILLIATVFETIQYFSWNKKQLLLRKIH
                     GYSLFSSNVRYLTISILLSIMLAYTTHILFGSKILLFIIMSIAIIQHLLQIAYIKYLEK
                     YFKDLMREI"
                     /name="bacteriocin-associated integral membrane family
                     protein"
     gene            complement(19517..19810)
                     /locus_tag="UXR30_13935"
     CDS             complement(19517..19810)
                     /locus_tag="UXR30_13935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="XAE32914.1"
                     /translation="MKKKFVSSCIASTILFGTLLGVTYKAEAATVHVAGGVWSHGIGKH
                     YVWSYYSHNKRNHGSTAVGKYSSFSGVARPGVQSKASAPKAWGGNKTFYSLH"
                     /name="lactococcin 972 family bacteriocin"
     gene            complement(20224..20832)
                     /locus_tag="UXR30_13940"
     CDS             complement(20224..20832)
                     /locus_tag="UXR30_13940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002436987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="XAE32944.1"
                     /translation="MIVGYARVSSNDQNLERQLENLKTFCAEKIFTEKQSGKSIENRPV
                     LQEALNFLRMGDRFVVESIDCLGRNYDEVIHTVNYLKDKEVQLMITSLPMMNEVVGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRI
                     IYHRVVEMLEEGQSISKITKEVNITRQTIYRIKNDNDLI"
                     /name="recombinase family protein"
     gene            complement(21201..22046)
                     /gene="blaZ"
                     /locus_tag="UXR30_13945"
     ARG             complement(21205..22046)
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            22153..23910
                     /gene="blaR1"
                     /locus_tag="UXR30_13950"
     ARG             22154..23907
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.56"
                     /coverage="100.0"
     gene            23900..24280
                     /gene="blaI"
                     /locus_tag="UXR30_13955"
     ARG             23901..24277
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            24544..25137
                     /locus_tag="UXR30_13960"
     CDS             24544..25137
                     /locus_tag="UXR30_13960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="XAE32918.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNQKDLNLLKTLYDNGTPI
                     KTIAEQWHVSRTTIYRYLNKLEDKEDEKQGEVSN"
                     /name="recombinase family protein"
     gene            25109..26552
                     /locus_tag="UXR30_13965"
                     /pseudo=""
     CDS             25109..26552
                     /locus_tag="UXR30_13965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790716.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Mu transposase C-terminal domain-containing
                     protein"
                     /name="Mu transposase C-terminal domain-containing protein"
     gene            26545..27360
                     /locus_tag="UXR30_13970"
     CDS             26545..27360
                     /locus_tag="UXR30_13970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019467708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="XAE32919.1"
                     /translation="MTKNQNFIETKEYKRFAEFCDACIKYQYIGICYGQPGVGKTLSSR
                     YYTNWDTIEKQVNHRGWEDLASKTTDDILSVDKIFYNAPAEKQTKLRNDLYSITAIIDL
                     GQKLHVVNKYGHEHSKHYSDMFKYIDLIIVDEIDRLKVQHLEQLRAIYDEHNLAMIFIG
                     MPGIEKKLSRYPQLYSRIGFAHEFDNLSKDETHHILEYKWQDLGFDLKLEDFTDYEAIT
                     TIIKITKGNFRLIHRLFAQIDRIMDINGLDKISTEVVETARDSLVIGIR"
                     /name="AAA family ATPase"
     gene            27613..29769
                     /locus_tag="UXR30_13975"
     CDS             27613..29769
                     /locus_tag="UXR30_13975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002440725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_component:
                     GO:0055052 - ATP-binding cassette (ABC) transporter
                     complex, substrate-binding subunit-containing [Evidence
                     IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA]; GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]; GO_function: GO:0042626 - ATPase-coupled
                     transmembrane transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="XAE32920.1"
                     /translation="MAIKFIRQYDEKDCGPTCLAMISQFYGKRVSIPRLREYAKTDKLG
                     TNLYGLVQAGKKIGIELTGVKADSFDDLKQAQLPVMVHIINQQGYDHYIIIEKIKNNTL
                     YIVDPAKGKYKLSSTEFGKYWTNIAVLIDKTDDFTTDNESPSYLNIFIDIFKNNYGKLL
                     FIAFISLFINIVGIVGALYFKLLTDHIIPSNVLKNLHIISFGILLLYIINALINYLRFQ
                     LILHLSLKIDVNLMKDYFYHVLHLPMNFFDTRKSGEILQRFMDTSKIREALSSSTVTLL
                     VDTFMIIIGAILLYMQSPLLLLITIIFIPCFIICSYTLRKPFEKYNQKVAEKDAELSSY
                     LIESFDGSNTIKSYQSEDDRFYIGTTKFNGIIENLLKLGRFSNIQLTVNNFLKLTISLV
                     ILWLGSYLVMTDSMTLGSLLAFNALTIYYLDPIERLINIQPTLQSSFVAARRIAEITDL
                     ETETELYTSKQPYTFKNNIRIENVNFQYGFRSVVLKDINLNIKKGQKVAIVGESGSGKS
                     TIGKLLNRYYTASEGNIMIDNYIIDDIDLSDLRKNIGYVSQNTFLFADTIKNNLLHGSN
                     KYKSDEDIVKACQLAESLDFIQKFPDQFNTMLEKEGANLSGGQGQRLSLARTFLKDPDI
                     YIFDEATSALDSLTENKIMEHIDLLTQHGKTVIIISHKLSTIKNADNIYVLNEGQIAEN
                     GTHDELIHLNGIYKNLWQLQMKID"
                     /name="peptidase domain-containing ABC transporter"
     gene            29926..30069
                     /locus_tag="UXR30_13980"
     CDS             29926..30069
                     /locus_tag="UXR30_13980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019469205.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-type signal sequence"
                     /protein_id="XAE32921.1"
                     /translation="METLNEKQLKDINGGRETGCSGDFVEDGIMCNIGQGIGKAINKVR
                     GK"
                     /name="bacteriocin-type signal sequence"
     gene            30090..30239
                     /locus_tag="UXR30_13985"
     CDS             30090..30239
                     /locus_tag="UXR30_13985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019469204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin"
                     /protein_id="XAE32922.1"
                     /translation="MKTLNEKQLKDINGGKGIVGEVTGEVTSIGNAISNGWHDLKQSVA
                     DTTK"
                     /name="bacteriocin"
     gene            complement(30362..30628)
                     /locus_tag="UXR30_13990"
     CDS             complement(30362..30628)
                     /locus_tag="UXR30_13990"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="XAE32923.1"
                     /translation="MQTVSLVIKKIKDAKMAKYWKENQEGLLNDGEALTILMILYNEHP
                     YVVQLPCLNKQLQDDNRYAQPTYTIYSTTKNRKENKRRIKNSI"
                     /name="hypothetical protein"
     gene            complement(30965..31066)
                     /locus_tag="UXR30_13995"
     CDS             complement(30965..31066)
                     /locus_tag="UXR30_13995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="XAE32924.1"
                     /translation="MVEALVHITTTVISGCIVALFTHWLRTRNNKKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(31235..31582)
                     /locus_tag="UXR30_14000"
     CDS             complement(31235..31582)
                     /locus_tag="UXR30_14000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]; GO_process: GO:0006355 - regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="XAE32925.1"
                     /translation="MSYENACDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKISVASTSHHLRLLYKNDVLDFYKKGKMAYYFIKDDEI
                     KEFFSKNQEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(31601..32218)
                     /locus_tag="UXR30_14005"
     CDS             complement(31601..32218)
                     /locus_tag="UXR30_14005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017465246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CadD family cadmium resistance transporter"
                     /protein_id="XAE32926.1"
                     /translation="MIQTIVTAAILYIATAVDLLVILLIFFARAKTKKEYRDIYIGQYV
                     GSVALIVVSLFFAFVLNYVPEKWILGLLGLIPIYLGIKVAIYDDCEGEKRAKKELNEKG
                     LSKLVGTVAIVTIASCGADNIGLFVPYFVTLSVTNLLITLFVFLILIFFLVFTAQKLSN
                     IPGVGEIVEKFSRWIMAVIYIALGLFIIIENDTIQTILGFIF"
                     /name="CadD family cadmium resistance transporter"
     ARG             complement(5509..6278)
                     /name="ANT(4')-Ia"
                     /gene="ANT(4')-Ia"
                     /gene_name="ANT(4')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.21"
                     /coverage="101.19"
     ARG             complement(21202..22046)
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     BGC             14517..32592
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(3595..4495)
                     /name="rep_cluster_1118"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="95.0"
                     /evalue="0.0"
     Typing          complement(10369..11303)
                     /name="rep_cluster_1215"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.145"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(13806..14665)
                     /name="rep_cluster_2214"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(687..1864)
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="95.0"
                     /evalue="0.0"
     Typing          complement(16043..16317)
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="94.565"
                     /coverage="100.0"
                     /evalue="4.72e-46"
ORIGIN
        1 ttctttttat atagagcgta aatacattca atacctttta aagtattctt tgccgtattg
       61 atactttgat atcttgtctt tcttacttta atatgacggt gatcttgctc aatgaggtta
      121 ttcagatatt tcgatgtaca atgacagtca ggtttaagtt taaaagcttt aattatttta
      181 gccattgctg ccttcgttga aggtgcctga tctgtaacta ccttttgagg cttaccaaat
      241 tgtttaatga gacgtttgat aaacgcatat gctgaatgat tatctcgttg cttacgcaac
      301 caaatatcta atgtatgtcc ctctgtatca atggcacgat ataaatagct ccattttcct
      361 tttattttga tatacgtctc atcaatacgc catttgtaat aagctttttt atgctttttc
      421 ttccaaattt gatataaaat tggggcatat tcttgaaccc aacggtagat cgttgaatga
      481 tgaacgttta caccacgttc tcttaatatt tcagatatat cacgatagct caatgcatat
      541 cttagatagt agccaacggc tacagtgata acatccttgt taaattgttt atatctgaaa
      601 tagttcatac agaagactcc tttttgttaa aattatatta taaattcaac tttgcaacag
      661 aaccttcttg ttgctgttcc tgttctgaat ataattctgg attcattttt ttatctaagt
      721 ttcctgctaa accatttagt tttggttcat cttctgttaa cttattaact ctttccgcaa
      781 aggtatttct tcctaaaact cgttctaact cttttagtaa gatttttaaa agctttaacg
      841 ctatttctat attctcttta agtggctttg cattttcgta aagttggtta aaattatcgt
      901 ctgcgttttc aatacgctca actgctttat ttaataaatc atctttctct cgtatttcct
      961 tatctttatc atctaaggct ctaccagact ttatatactc gtaatcttcc gaaatatctt
     1021 gagcagcttt tatctgtttc tgaaattcat tgaaatcttt ttggcttatt acaacatttc
     1081 cagtttcttg tatttctttg ctaaataaac cacctacttt ttcagtttct tgctcatacg
     1141 gaacatttat aggcttttta agcgtattta acgatttttg gtactcttgc attaatttat
     1201 cgttcttttg ctttatatgg tctgtttttt ggctctcacg ttcatattct tgcttatgat
     1261 attctgtttt ttgtttatac tgacttattt gctcatgttt agcatttgtt acttgtcttg
     1321 attgcccacg ttctaaatca tatcctcgtt gtttaacatg ctcattaaat ctatcttgaa
     1381 acgctgttaa agctttttta ttacctacaa cttctttagc acttaaacga ccatcatcag
     1441 ttattggaac aacgccataa tgcatatgtg gtgttttttc gtccatgtga actgttgcat
     1501 ataataaatt atctttaccg tattcttgtt ctaaaaactc tttagcatat tcaaaaaact
     1561 gctttgtatc ttctggcgtt tgattatcaa agaaatcatt gtctgatgta attaaaccat
     1621 caatgtgttt aatcgcgtct gttctaattt ttcttttgcc tgtataattc tgttcgattt
     1681 tttcatcaat caagttatta aaattctgtt tattagcatt taccaaatca taatttaagt
     1741 aagttttact atggtctata tcttcatttt cataattatt attttctctt tgaacatgtt
     1801 tttgtatgcc cgttgtattt gttccagatt taacttttga aactctaaca atggaataag
     1861 acatataaaa atcactccta agcacaaagg tttcatgtgt atttaatagt ttaagtctaa
     1921 taacacacta gacttatttt taataagtcg ttaatacgtg tgctctgcga ggcttaaacc
     1981 tgtttttgct aacgcaaaaa atgagtggca aaatgctagc cactcatagt tctaaaccaa
     2041 aatataatat aactattcaa actgcttttc agaacgttta aatacaataa tcgtcaaaag
     2101 acaacataaa ataataagga tagccatggc tacaagaata ttactataca ctccagaaga
     2161 ataatttata aattccagaa ctagtttacg attaatcaat tgtagtgaca ataaacctcc
     2221 tacaattgct atacctgttc cctctgataa aaaacttgtg aaatttagca aactcattcc
     2281 agaagcaact tcttcttcag aaagactact tgatactatt tttgatataa ctgttttagt
     2341 aaaagataat ccgcccataa caaatataaa cataaaagta gtcaaccaca tactaaactc
     2401 aacaaaaaat gcaatagtta aaaaacttat agagatagac aatgatccta aaataaaaac
     2461 aaataatgat ccttttctat ccactaaaaa accaccaaaa taaccaaaaa caataacact
     2521 catggttcca ggaaaaataa cactattacc tattgtcgct acatttacat gataaatagt
     2581 tttcatcata taaggcacca ttgatataaa accagctact atagaaaata ttagcccacc
     2641 agaaaacaaa ccaagcataa acggaatgtt tttccctagt ttaggattaa taaaagggtt
     2701 agaaactctt gaaatatgtt taataaaaat cacaaaaaag attgtgaaga gtattaaaaa
     2761 agtccaatta taatttgtcg taaataacat aaaacatata atacttatag acattaaaac
     2821 aatacctacg atatctaatg tattttttgt tgatttacca ggtaccatta ctttaataag
     2881 aaaaggtata gttactattg taatcatagg aagtataagt aggtaagacc aatgaatata
     2941 atgtgctatt attcccccta ttgaaggacc taacccttca cctaaagcta caattgatcc
     3001 tataaaacca aaggctttgc cttgtttttt tcttgtaata tttctagcta caaccaccat
     3061 aatcagtgaa gggaatgcag cagatcctac tccttgtact aacctaccaa aaatcaaaat
     3121 aaaaaagtga ttgtgaccaa taaaagcaat caatgaacca agacagctca aactaatacc
     3181 aataattaac aattttttta tatttatata atcagataat tttccatata ctgctgttcc
     3241 tatcgaaaaa gttaacatat atgcagtgtt tacccagttt gtaattccag gagtagtatt
     3301 aaaatgattt gcaatatcag gtaaagaaac atttaaaacc atttcattta atacactaaa
     3361 aaatgaaaga atacaaagcc aaaataaaac gctataaaac aaacctttaa attttttata
     3421 taaactaaac aattttacct ctttacttga ggtgactaaa gtttataggg gtaaattatt
     3481 ctttcacctc atataaattc cccaaatttt taaatagaca cttcataaaa aaatcctcct
     3541 aaattagaat agtttaaata tatcattttt gttcagtaat attaatatgt acactatttc
     3601 caaaatttaa attcatgttg ccaaaaatcg atttgttttt gcaattgttt ttcgttcgct
     3661 tttaaagtcg atttcattaa gtccgttaaa tcgactggcg aaatttcttt tatcaaattc
     3721 ttatattttg ttctagaatt tctgtgaagc tttccccatt cttcttcatc actcaataac
     3781 ataaaaacta ttgctctatc cgcagtgcgt tggatagttt tccaatctgg ttgcaagata
     3841 tgtaaatcac taaagcaatc attccagtaa tccaccatat ctcttttaag ttcgatttct
     3901 acacgccata aatgttcaga cataacttca gcatctgcat tatctttacg ttcttgcttt
     3961 ttattataaa ttctaataaa tctattacta tctctcacgc caaaatattt tgtttctggc
     4021 ttaccattac gaccataaaa aatagttttc ttaactgctt tatcagacat tgcatagtag
     4081 tcactcaaat catcttcaaa atcaaaggct aaatctaatc ttgtaaaacc gtcatcttcc
     4141 atgtagctta ttatattttg ttttaaccaa atcatttcat ctcgtgtaag tttgtttgga
     4201 ttaaattcaa tacgcatatt acgtctatcc caactatctg ctttcacttt gtcatattca
     4261 atataaactt tttcttgaag tgctttagct ttaaactttg tttgaagaat atcccaaagt
     4321 cttatttggg gctctacact cataaattta gaaagggctt gagcgttgtc tcggttgaga
     4381 tttccaacga tcgtcattgc atcaaaactt aattttggat cagatatgca cacagtatgt
     4441 gcgtccaacc ggctattaga gtagccggtt ttagaaaaat tgtctaaatc gtgatggttc
     4501 tgttgcaaag taaaaaatat agctaatcac taatatatca tgtcagtgtt cgtttaactt
     4561 gctagcatga tgctaatttc gtggcatggg gaaaatccgt agatctgaag agacctacgg
     4621 ttctttttat atagagcgta aatacattca atacctttta aagtattctt tgccgtattg
     4681 atactttgat atcttgtctt tcttacttta atatgacggt gatcttgctc aatgaggtta
     4741 ttcagatatt tcgatgtaca atgacagtca ggtttaagtt taaaagcttt aattatttta
     4801 gccattgctg ccttcgttga aggtgcctga tctgtaacta ccttttgagg cttaccaaat
     4861 tgtttaatga gacgtttgat aaacgcatat gctgaatgat tatctcgttg cttacgcaac
     4921 caaatatcta atgtatgtcc ctctgtatca atggcacgat ataaatagct ccattttcct
     4981 tttattttga tatacgtctc atcaatacgc catttgtaat aagctttttt atgctttttc
     5041 ttccaaattt gatataaaat tggggcatat tcttgaaccc aacggtagat cgttgaatga
     5101 tgaacgttta caccacgttc tcttaatatt tcagatatat cacgatagct caatgcatat
     5161 cttagatagt agccaacggc tacagtgata acatccttgt taaattgttt atatctgaaa
     5221 tggttcatac agaagactcc tttttgttaa aattatatta taaattcaac tttgcaacag
     5281 aaccttctca cgcataaaat cccctttcat tttctaatgt aaatctatta ccttattatt
     5341 aattcaattc gctcataatt aatccttttt cttattacgc aaaatggccc gatttaagca
     5401 caccctttat tccgttaatg cgccatgaca gccatgataa ttactaatac taggagaagt
     5461 taataaatac gtaaccaaca tgattaacaa ttattagagg tcatcgttca aaatggtatg
     5521 cgttttgaca catccactat atatccgtgt cgttctgtcc actcctgaat cccattccag
     5581 aaattctcta gcgattccag aagtttctca gagtcggaaa gttgaccaga cattacgaac
     5641 tggcacagat ggtcataacc tgaaggaaga tctgattgct taactgcttc agttaagacc
     5701 gaagcgctcg tcgtataaca gatgcgatga tgcagaccaa tcaacatggc acctgccatt
     5761 gctacctgta cagtcaagga tggtagaaat gttgtcggtc cttgcacacg aatattacgc
     5821 catttgcctg catattcaaa cagctcttct acgataaggg cacaaatcgc atcgtggaac
     5881 gtttgggctt ctaccgattt agcagtttga tacactttct ctaagtatcc acctgaatca
     5941 taaatcggca aaatagagaa aaattgacca tgtgtaagcg gccaatctga ttccacctga
     6001 gatgcataat ctagtagaat ctcttcgcta tcaaaattca cttccacctt ccactcaccg
     6061 gttgtccatt catggctgaa ctctgcttcc tctgttgaca tgacacacat catctcaata
     6121 tccgaatagg gcccatcagt ctgacgacca agagagccat aaacaccaat agccttaaca
     6181 tcatccccat atttatccaa tattcgttcc ttaatttcat gaacaatctt cattctttct
     6241 tctctagtca ttattattgg tccattcact attctcattc ccttttcaga taattttaga
     6301 tttgcttttc taaataagaa tatttggaga gcaccgttct tattcagcta ttaataactc
     6361 gtcttcctaa gcatccttca atccttttaa taacaattat agcatctaat cttcaacaaa
     6421 ctggcccgtt tgttgaacta ctctttaata aaataatttt tccgttccca attccacatt
     6481 gcaataatag aaaatccatc ttcatcggct ttttcgtcat catctgtatg aatcaaatcg
     6541 ccttcttctg tgtcatcaag gtttaatttt ttatgtattt cttttaacaa accaccatag
     6601 gagattaacc ttttacggtg taaaccttcc tccaaatcag acaaacgttt caaattcttt
     6661 tcttcatcat cggtcataaa atccgtatcc tttacaggat attttgcagt ttcgtcaatt
     6721 gccgattgta tatccgattt atatttattt ttcggtcgaa tcatttgaac ttttacattt
     6781 ggatcatagt ctaatttcat tgcctttttc caaaattgaa tccattgttt ttgattcacg
     6841 tagttttctg tattcttaaa ataagttggt tccacacata ccaatacatg catgtgctga
     6901 ttataagaat tatctttatt attggttctg ttgcaaagtt aaattaatat acaaagttat
     6961 gcaaaagcag taaattatat actattatat caacagatta ttcggttgga ttttattatt
     7021 tttcatttct ttgtatctat attatatgat tttcaagttt gcaacagaac ctgaattcgt
     7081 atatcctaat ctaaaaacat ttattttcct agtatatttt gctaaatcag atttcaaact
     7141 attaataatc ctatcgctat tttcttcgaa ctgtttgttt ttttcttctt tatctttttc
     7201 ttgttgctta acgctattat catatgattt atatgcgata acaagactga taacagttgt
     7261 aaggagagtg aataatgcta caaatgcttt taaaatattt ggatattctt ctagaattcc
     7321 ctcaatttga taagagtatt taaaaacaat aaatatggag accactatta tgaaaatcga
     7381 tatacgtaac atcttcttca ttctaaaact tcctctctaa gccatataaa aatgttactg
     7441 actcacatta ttatcaaatg attcttataa tatataacat atatcagtat agttattaaa
     7501 acatcaatta aaaatgcatg ttttataaat atcattaacc ctattcctat ttatatatac
     7561 tacagatata aataaaataa ctccgtaatt ataatattta cgctcaaact ttatgaactt
     7621 tgcattccta ccaattatag tgttacaatg taattaacaa agattatcag gcatgtatgc
     7681 accaaatccc cttactatgg ccgtagtaag gggatttttt ggtgtgacta gtcgcctatt
     7741 cgtcattacg cttgcgtagc caatgcgcaa atagcgcaac gagacaacca cttgctgctg
     7801 tggtcatgat gttcacaaag atttcagaca tcgcgtatgc acctcctctc tacgtcaaat
     7861 tgacgcctga gagataggcg actctattat tatatcattt gtaaatacat aagcatattc
     7921 acttccgata agtcatttta tattatatct ttgcttactt ttataaagaa actcgtttct
     7981 aaattcaata aaaaattgct ttatgattaa atttcaaata tcgtttgaaa aatttaaata
     8041 aaaatacact gacttttttc aataaaggaa ttgataacaa accaataaca acgaaaataa
     8101 cagtcataac tagttgaatt acattaaact cttgtacacc cgttaaaaca aagattgcta
     8161 aaatcaaagg actaaataac atagctaaag aaatgaataa agataataac aaaaagccac
     8221 caaaaaatat aactattaaa gaaaataaaa acacattaaa taatatcgct ccaaataaag
     8281 caaaaggatt tacatttttc atacttttag cctccttatt ttctaatgct gtatttacta
     8341 ctaattcatc taaagaaata tcataaagat tgcttaattc ttgaattaca taaatattag
     8401 gcaacgtttt accttgctcc catcgagaaa cagtttgtct agtaacgtat aattttttag
     8461 ctacctcaga ttgcgttaat tcctttgcta atctcgcaga ttttaattta ttcgatatca
     8521 taagcttctc cttgtttttt ataaatttat aatctcacaa caaatccaaa ttaaaagaaa
     8581 caaacctgtt acatcccaac gaaatcaatg atgtaacagg tttaaaacat taatacttta
     8641 tcacaattgc tccctaaaat tgtcgaatgg tcggcttaat agctcacgct ataccgacat
     8701 tcgtctataa gtttagttaa gagttcttct caacgaacaa taaatttttt cgtcataaat
     8761 gctacgttat aattaaaata tcttttcttg attttttggt attattttca cttttatcat
     8821 ccaaaaagtg agtaagagct actgaaattt taagttagct cttaaaacgc aaatgagaat
     8881 caaataaata taaatgtatt tcacaaacaa aaatttgagt aatcattcga tgaatcttat
     8941 tatatatttt tccgtttttt taattttcta tttaataaaa agataaagtg atctttattt
     9001 cgggtcactt tttaataaaa tcgagcatag aaaagtatag aaattgtttt attctttccc
     9061 ttcttttttg aacttaaaaa taaataataa gatcattatt gaatacgata ttgagcaaaa
     9121 agtatttagt caatttcaaa aagtaaaaca aatgaatgaa ttacttagat tacttttgag
     9181 tgattttatt tttgatatta atactaaaag taataggatt aataggattt ggataaaaaa
     9241 atcaatccta tttataggat tgacgacgac tgaagcctat gaaatcaata aaaacaatag
     9301 tattcagaca atttaaagtg gtcttgtaac aattgtaaat agtatgcaat attaaggttt
     9361 ataatgtcga ttaattttta tttaatatta actataaatg ttgttatatc aacacttgta
     9421 gtgaatttca aagagcaagt aagcaaagcg aacggtaaga caatccttca gctatgctga
     9481 ataccaccaa aggtggtact ggatttcctt atgctcatgt caaatactat ttgaaaatcc
     9541 tgttatattt gtaatatttc caaaaacaaa acgtgcttta agacaaaagt ggctattctc
     9601 ttgttcactt tttactttaa gtgcttattt ttattttcaa aataagcatt gttagtaaaa
     9661 taattggaga taaaaaaaaa agaaaactaa gtaaatatct ttactcagtt tgggatagaa
     9721 aaaatcaaat ttaaaattac attcgactta tgtcttgaac attaacgact tactttttgt
     9781 ttatgatgta tatcaattga atctgaattt tgattttttg gaatgataaa atcaatcttt
     9841 tctttccgat cattaacaaa gtaaatgaca aaaacgattt tattaagtta cttttataac
     9901 taagaaagat tgctaaagaa tataaaaacg gttagtattt ttataatttt taaagttaaa
     9961 acaacgttaa atgatcattt tatttttcat cttatgcgac atgtttgagc cattttcaaa
    10021 tgaataataa ccatttatag aaaaaatagg actaaaacag aaacgtttta gtcctaccta
    10081 cttgtttaac tacagttcat tttcagattt actcaattgc cattgaagat aaagttcgac
    10141 tgcagttaaa agaacattaa tcattgccaa agtaacttta atctttttct tagtactcat
    10201 aattcttcct cctttcttta atagcagcat gctatattgt gatattgtgt tgatcttatt
    10261 ttgttatccc ctcccttacc tttcgtttga tctaggtggt tgccttagca accacttgta
    10321 aataaaaaaa gagaacatct atttaaagat gctctctaat tgaatcatta ttgattaaat
    10381 aaagaagtga ttggtaaatg atcacgtcgt ttattaagcg tatgcatttc agcgaattca
    10441 gacttaaggg atttcattaa gtacccttgc atggcttcaa cggtttcatt tttttgaata
    10501 agcatagctt tgaaacgttt aagaacatga agtatttcta tttccatatc ttctaataag
    10561 taatatgtat caatagaatt attaaaggac gtcttggctt ttaataatac aggtttgatg
    10621 attttaattt catttacaga aaagttactt aaataccttt gaatactttg aggtagttct
    10681 tcgagtaatt ggaattttaa agcttcatta ttaaagtttg aattgttgtg atttgaatga
    10741 tttgtatgat tactaggaaa agttagctta ttatcattca aatcattcgt atcattactc
    10801 tcagttttaa tataatcagt atcattattc tcagtatcat tagactgtga atttggaagt
    10861 tcttgaccac ttaaattcac agttctagaa cttccaaatt cattgttctg gaactgtgaa
    10921 tttggaagtt ccttgctatg actggcttta atgtcataat taggttttaa taaatataat
    10981 ctatttggtt tattaaggcc aacacgttct tgagttaata aattaaaact tattaactct
    11041 ttttttaatt ttataatttt ttgttctgca taacctaagt attcgcacaa atgtttatta
    11101 ctgaaaataa agtaaatgtt attattttta tctacccatt cattttggat ggataattca
    11161 aagcgatctt ttaataacgc atacataatt ttggcttccg ccgacatttt tttaaaatat
    11221 gcatcttcga ataaatattt aggtagttga taaaaccttt cagtttttac ttgtgataaa
    11281 ttgtattttt caaaattggg cataataaaa acctcatttc catttttagg attgaggtaa
    11341 taaaacaatt tttacgtaag ttatatgttt tgtgcttgca cttagatgat tagatagata
    11401 taatacaagt atcaaaaaat atataaacaa acgagtgcga atcgttttat taccgagagt
    11461 caatgctacg ccaatagcat tgactctttt agtatttata aagcaatatt aacactttta
    11521 agaaagtata taaagagttt taaatgtagt taaaagcaca ttgccatggc aaaatgtgta
    11581 gttcattgtt ttagtaccta attaagctcc aaaaacatat tataggtagc taattaggtg
    11641 catatgtagt aaataggtag taaatttagt ggtaattgat gaaataaaat tcattaggtg
    11701 gtaaaattta ggtactaaat taggtaccta agggtggatg ttatgagaac tattaaaatg
    11761 gttgctgatg aattaggtgt aactaaacaa actattgtta ataatgctaa aagtttaaat
    11821 ataacttttg aaaaagaaaa tgggattaat tatattgatg ataatgatta tttgaaaatt
    11881 atagaaaaaa ttactaagaa agagagtaca atccaaaata aagaatcagt aaaaaaagaa
    11941 ttgtttggtg aaaatactgc aaaatcagaa aagaatatat ataataattc aaatagttct
    12001 gagacattaa aaacaaaagt aaacgaatta gaaaagcaaa tagaaatctt tgaaactaga
    12061 gctaaaaatg atgaaaaata tattgagaat ttaactaagc aattagatca acaaaatagc
    12121 aatgttaata cgttaaataa attgttggag aatcaacaaa tattagcttt agaaagcaat
    12181 aaaaaaattc aaaaactaga aagtcaatta gaagaagaaa gacagcttaa ttattctttt
    12241 gatacagcga cgaataatag acaaaatatt aatccgcaag aagcaacttt tactgaagaa
    12301 tcgcaaaata tcaaccaaca acaaacaaag cgtcaaccaa cagaagtaaa ttacaaggat
    12361 atagccgaag agaaaaagaa tgacagtaca gatgaaggtg aattaacaaa agaggataag
    12421 ttcgttgaag aaacgaagaa tgatcctgat gataataggg aggtagaacc acctaaaaag
    12481 ggattttgga gtcgattctt cggtaattaa aaatgaatgt aaaaggtgta tcaagggagt
    12541 ataaatcttt gatacacctt ttatagtgat gaaacttctg ataatcatcg attatgttaa
    12601 ccaaacaaaa agccataaat gcctatatga cggcatttat ggctttttac tttcattatc
    12661 ttttatgcat cttttataca tcgttgattt gacgcgtttt cattcttttg cattggcaag
    12721 tattttgtat ctttattcag ttactatttc ttttctccaa cctaacaaac catctttaac
    12781 tctaataata tgtttgccac gccagacact tcttacttcg aaataatacc attccccgtt
    12841 tttgttgagg aaataaatat cttgataacc ttctttaatg acatattttg tagcttcttg
    12901 tctttgatcg ccaaacatta tcaatcccac ccttatattt atttatcttt aatatataac
    12961 aacatttatt aatattcatg ttatttcatg gaaggagaga tttgttataa tgtgaaggtc
    13021 gtctatctct cagatgtcaa ttcggcgtag agaggaggtg cgatttatga atgaaattct
    13081 tgttcacatc atgacaacgg caatcagtgg ttgtctcgtt acgttatttg gttattagct
    13141 ccataaacgt gataaaaaat aatatagacg attaaagcca attcaccaaa aaaccccgaa
    13201 ctacggcgaa tagttcgggg ttttgtgcgt ttacaaacga aattcttgtt acttttagta
    13261 tatatttcat attgcctttt gtaaactctt ctattcttat caatacattt caaggtgtcg
    13321 taaaaatact ttcctttttc atattgcctg atgtgcatta aattttgatt ttaaaatcaa
    13381 cccatgaacg aatgaatggc ccaaactaaa aatccggcaa caggaaagaa aagccaccaa
    13441 aaatcataaa gaaaatcaac tatggaaggt accctgttac tctctctata atttccctct
    13501 aaaataactt ttttaaaacg tgcatctcct ttaattaagt gctctaaaga gattccgaat
    13561 aaatcgctca tagcaatcaa aatatctaag gaaggatagt ttttggcact ttcccattta
    13621 gaaacacttt gtctggaaac ctttaatata ttggctaatt cctcttgaga ccatcctttt
    13681 aattctctct gttcttttat agcttcagct aatttcataa aatcactcct taactcaaac
    13741 tataattaaa ataattgaaa agtcacgata cttttagtta accaactcgc aacgaaaagt
    13801 tgcgttattc ccaattcagt tcaagttgtt ttaaaaaatc ctctcgttct ttctctaatt
    13861 gtgggtcgta atctttttga ggttgctttt catatgaccg ttcttctaac catttaggcg
    13921 tcttttcacg cctcacatat tgtcttgatt tatctatctt ggacatttga ggttgtcgtt
    13981 tgttatgaat gcgtttctca gcgtcaaatg tgaactctat ccattcaatt ttacgccctt
    14041 ttttcgcttt gattttattg atagtaagat tattaaatat agaacctaat tcaataataa
    14101 taggtttaaa aacatttttg ttaatatcag tcatacgata agatttaggt atatctaaac
    14161 gatttttaaa atcatcgatg tgaattttta aatagcctgt atgtttgtat tgtttaagta
    14221 atctaaacat atttttagaa tatgtagatt taagcctagt catttctttt aattcaaatt
    14281 ttgtaaaatt attagtaatt gaattcaata tgtgttttaa atttgaagaa gttgatattt
    14341 ctagatattg ttctcgctta tggattctat aatgattgaa taaaacgaat ctttctatta
    14401 catcatcatc ttcatatcta atggttaaat tcaacatctt tttatacaca ttatctaaat
    14461 cattagcaaa tctattaata ttacgtgttt ctggactata attacttaat ttttttaatt
    14521 catcaaaaga caaacgtaat gtattagtat cttgctcttt taatttatta cacatcgcaa
    14581 aaaataaatt aatttcagta gctgtaaatc gccttaatgg aactaaattc atttcatttt
    14641 tatatacaac tgtctctcct gtcatgatac agcccccttt attacgaacc taaaggagta
    14701 tcgtttgaat atacactccc atttgaaaac ttttattcac aataaactac tttattatca
    14761 atgtcaaacc ataaaaggag tacaactttt taaaacactc cttttatgtg gcaaaaacac
    14821 tccttttatg tggcaaaaac actcctttta tgtggcaaaa acactccttt tatgtggcaa
    14881 aaacactcct ttaggcattg aaatcccttg ttgctctagg gctgaacaag cccctaaaaa
    14941 ggtttttaaa aagatttata aaaatatatt aaaaagttcg aggggggcta cctatttttc
    15001 atcctaaaaa ataattaacc tcaaacaaat gcatttaaat atctattttt ataatgtata
    15061 accatcttct ctatcttctt taaaaatgat ttctcgttct tgtgcttgat atttcttctt
    15121 aaagaactgt tcatcattgt tatctatcgt cattacttca cgtattttag aattgtctaa
    15181 atgattatca atatgattta ttagtgtatg ataacgctct tctttcatca tacttttaat
    15241 gattttaaaa acttgattga ataacttaag cgtataattt agttctttat ctttcttttc
    15301 attctctgac aacaaataat tataacgttg tgctaaatca ttaaattctt caaccagctt
    15361 ttcattttcc atatggacac tagtcaattc attaactaaa ctttcatttt gtttctctgc
    15421 tttttttaat gacttcccac ttttaataca ttcataatca tctaatatca tctgtgctgc
    15481 tttaatttgt ttagtgtatt tttcaaaatc agttttagta attacaatat tgcctgtttc
    15541 ttgcttctct ttatgaaacc atccacctac atttttagtt ttaatttcat acatgacact
    15601 cagaagcttt ttaagcgtat ctaatgattt ttggtagttt tgtatcaatt tatcattttc
    15661 ttgctttaaa taatcctcta tttgcttcta gcgcatatgc atttgtttat gatattctgt
    15721 tttttgttta taacggctaa cttgatcatg tttttctttt gtaagttgtc tagaaattcc
    15781 tcgttttaaa tcatagcctt gcttattaat atacgtattg aatctatctt ggaattcggt
    15841 taatgctttt ttattaccta caacttcttt cgcacttaaa cgtccatctt tagtaatagg
    15901 aactacgcca taatgcatat gtggtgttat ctcatccata tgtactgtcg catataaaag
    15961 attttcttta ccgtattctt cttccaagaa cgctttagca tgcttaaaaa actattttgt
    16021 ctcttcttca gataattgat taaaaaacac attatctgat gtaattaatc catcaatatg
    16081 tttaatggca tctgttctaa ttttgcgttt ccctttataa tttttttcga ttttctcatc
    16141 aattttttta ttaaaatcaa acttagtatc attgactaaa tcatagttta aatatgactt
    16201 acttaaatca atatctatat tttcataatt tttattttct ctttgaatat gtctttgaat
    16261 acctcttgta tttgtttttg atttcacttt aacaactcga ataattgaat aagacataat
    16321 aaatcaactt ccactgcata tgattataac acctaaacac agaaaagttt taacatacta
    16381 gacttattaa aaaccaaata agtcattaaa aacgtgtgct ctgcgaggct tgttttttgt
    16441 catcataaaa aaggactgga aaatccagtc cttaaattaa aaaactcaaa agtaatgact
    16501 aatcatattt catattgttt tttctctatg tatggctata cctatcaata tttcttaact
    16561 tctaagctca gaaatattga ctatgacatc aaatcgtttc gcaagctcta aatcatgcgt
    16621 tacgacaatc atagttttat tttcatcaag tagcttcaat aataaatcaa taactatttt
    16681 tccatttttc gtatctagtg acccagtagg ttcatcagct aaaatgattt tcggatcttt
    16741 taatattaat cttgccaatg ctactctttg ttgttcacca ccgcttagag aactaacaat
    16801 tctcttgata tctaaatcta ggccgacctt ttttaatact tctttcttta agttcatatt
    16861 atctttttta ttctttttga actttaaggc taaatctaaa ttttgactga ttgtttgatt
    16921 ttcaagtaaa gcaaaatttt gaaacaaata ccctaacgta tatctataaa aatcgacttt
    16981 cttttttagt aacttatctt caatatatat gcttccttgt gatacatctt cgaacccagc
    17041 gattatgtta agtaaagtag attttccagc gccactttct ccaactaaag catatgattt
    17101 tcctttttca aaattaaagt tacatccgtc taaaatgttt ttattacctt tttttacaaa
    17161 aacattttca agttttatca ctatcggtca cctcatttta aaaagctagg aatatctttt
    17221 gtaatgtatt ctatcgaacg cacatatttc cctttatgat ttactttcac atattctttt
    17281 gtaggatcat aacctaaaaa atccaattta taactctttt tttctccatt tttagagtat
    17341 acagttatat ttctatagtc ctgggtatct tttggaactt tggcataaga tactttttct
    17401 tttaacagtg ggttaaaacg atctaaatgc tcatttctaa ccaataacag actaagtatg
    17461 atgattaata gtacaattgt tacaataatt aaagttcttt tcattgttta aatctccctc
    17521 attaaatctt taaagtattt ttcaagatat ttaatataag caatttgaag taaatgttga
    17581 ataatagcaa tagacattat tatgaatagt aatatctttg aaccaaataa aatatgcgta
    17641 gtgtaagcta acataataga aagtaagata gaaattgtta aataacgtac attactgctg
    17701 aataatgaat aaccatgaat ttttcttaat aatagttgct ttttattcca gctaaaatat
    17761 tgaattgttt caaatacagt agctatcaaa agaatgaaaa cgttaataat aatagtaact
    17821 attgttatta tcatttttgt tttcgtttca tttaattcat ttaacacaga atccttgtaa
    17881 ttagttatac cgctaatttc ttcttctagg tgattatctt taagcaactg tttaagtgta
    17941 tctaaatctt taaatagata tccaccttga gaaacagcag ctaaataaaa atctcctgtt
    18001 aaatcgtcaa gtgtcaacaa cattactatt ggagaatcta gatacccaaa tttcaaatta
    18061 gttgtgcgat caaaagaaaa aacagatacg ttttttgaca gtacttgcac atctactttt
    18121 ttgttttgtt gcttttgaaa gtcaatccat ccttggtgat ttttttgaat ttcagatttt
    18181 tgatattgta accttggagg aataaacacg tttattttat ccgaatgatt gtcaatcatt
    18241 ttaaaatcat gatttatatt tttatagaaa ttcagaaaat tgttattgat aaaaaagaca
    18301 ttgccatttt caggaatgta attgttttta tcgggattgg ctatattatt attctttaaa
    18361 agcaatccac caagttgttc gcttttctta attaaattgt atatattagt ttctaaaatt
    18421 tgtttttctt ctgaatttct aatattagga gaaatctcta atgtatagta attatctaac
    18481 ttttgccaga ttttttcaga gtcatatata ttctttaact tcgtataagc atttaaattt
    18541 tgtgccagta aaaaagatag tattagcacc atgatacatt tggtgaaggt acccataaat
    18601 attgaaaact tatatccttt tttccctttt aagattaatg gaatacttaa cttcaaaaga
    18661 agactatacg aaatcagcca cagcaatgta gtaatacaag caaaaacaaa aagcaacacg
    18721 ataaatctac gaataaacat taagaaatcc aattctaaat tggctatatg aatgattaat
    18781 atattagcaa taaagaaaat agcggtaagt actagccaat aaatgatttt tatatgaata
    18841 ttatgaaaaa taatgcgtgt agttgaaaag ccatgtagct tttgaatagc ataaaatttc
    18901 aaattatatc ctctgtcata taagaagtac aaaagatata atacgcctaa gaatatgaaa
    18961 ggcactaata aatcattatc tatgactaat tcaaaaaata atatgtttct atttatgtat
    19021 tcaacttcag atgttaaacc agcttttttt aattcactcg taagctcttc tacattgaaa
    19081 tgttcaccaa taatataata ctttcctttt atctctctgt ttaataaatc tgatggagtt
    19141 aaaagtgatg ttttattacg tataaagtca gaattatttc gttttgagtt gaaaacaaaa
    19201 aattcttttt tattatcaaa atctttaacg gatttaatta tttgtatatt ttgatttttg
    19261 gcgcctgatt caatgacatc taacactttt gatttactgt tagatttatc ccaattagag
    19321 attgttaaaa tattggaact ttcaggtata atttcttcat tttctttgaa gaaaaataaa
    19381 aataatagcc ctgaaattaa taataaagta ctaaaatcta aaaataattt gaattttttc
    19441 atattgcctc tttcaagaga atagacagaa ttaagtttac ttaattctgt ctattctcct
    19501 taattaatat atgtaattag tgaagactat aaaatgtttt gtttccaccc caagcctttg
    19561 gagcagatgc cttagattga acaccaggtc gagcaacacc actaaaagat gaatatttcc
    19621 ctactgctgt tgaaccatga tttcttttat tgtgactata ataagaccat acgtaatgtt
    19681 ttccaatacc atggctccaa acaccaccag ctacatgtac tgttgcagct tcagctttat
    19741 aagttacacc taataaagtg ccgaataaga ttgtactagc aatacaacta gaaacaaatt
    19801 tctttttcat aaaaacacct ccatttaata ttctttattt attatagcaa aaataaataa
    19861 aatagagagt gagtaaaaat aatctaaaag tgttttttct gctctgttgc ttgttttgtt
    19921 catctatata taatattaat tctattatcc ttaaattaac tatcattaaa caacgatatg
    19981 acaatgtata ataaatacaa tttcactacc tataattcaa cattatataa actaaagtat
    20041 ttcaaataat taactgtatt aatactctca tcatgattgc gttataaaca ttcgttaatg
    20101 agaaaaagag agagcatatt tacgctctct tttcttgtct tattattaaa aactcataat
    20161 agattataat catctgtttt gagacgctgt gagaagctct cagttgcatt gaaacaaagt
    20221 ttattaaatc aaatcattat cgtttttaat tctgtaaatc gtctgccttg ttatatttac
    20281 ttctttcgta attttactaa ttgattggcc ttcttctaac atttctacaa cgcgatgata
    20341 aataatacgt ttctgtggat ctttagcatt tggtgaataa agtaaggggc gccctttata
    20401 tacgcctttt tccttcgcaa cttgaattcc ttgcgcttgt cgacgtttac tttcatttct
    20461 ctcttgttct gaaaccattg ctaatatttg aataattaaa tctttcataa acttatccag
    20521 taatggattg ccaaccactt cattcatcat aggtaagcta gtaatcatta attgtacttc
    20581 tttgtctttt aaataattaa cggtatgaat cacttcatca taattacgac ctaaacaatc
    20641 aatggattct actacaaacc gatctcccat cctcaaaaag ttaagtgctt cttgaagtac
    20701 tggtctattt tcaatagatt tcccagactg tttttctgta aatatttttt cagcacaaaa
    20761 cgtctttaaa ttttcaagtt gtctttctaa attttgatcg ttcgatgata ctctcgcata
    20821 gccaacaatc attgatttcc atctcataat taatatacac cctaatcata cgtttcagtt
    20881 actataaatt caacaattat gtcactttgc ttgatatatg agaattattt aaccttataa
    20941 atgagaaaaa agcaacgcac tttaaataag atacgttgct ttttcgattg atgaacacct
    21001 ataattaaac tattcatcta ttatttatga ttttttgtat atacaatatt tctagtttgt
    21061 taaagagaat taagaaaata aatctcgaaa ataataaagg gaaaatcagg ttttgatatc
    21121 aaaattatac atgtcaacga taatagaaaa tataatacaa actataagat gttatcagta
    21181 tttattatgc atttagaata ttaaaattcc ttcattacac tcttggcggt ttcacttatc
    21241 aacttatcat ttggcttatc acttttattg tctttattcg taaaaatgac taaaacaata
    21301 ggttcagatt ggcccttagg ataaacaaaa gcaacatcat ttctagaagc atatgttatt
    21361 gcttgaccac ttttatcagc aaccttatag tcttttggaa caccatcttt aattaaagtg
    21421 tctccgtttt tattattaaa cattaaatca agtaagaaat ttttattttt tttgcttaat
    21481 tttccatttg cgataagttt atttaaagtc ttgccgaaag cagcaggcgt tgaagtatct
    21541 tttttgctct ttggcgaata gtaatttaat tctatctcat atctaactgg atttgttact
    21601 ttatctccta gttcttttag acgttgttta acttttttga ttccaccgat ttcttttata
    21661 attttattgt ttgctgtatt atcactatat gtcattgaag cctcaataag ttcttttaaa
    21721 gtgatgtctt ttcctacata tttttctaaa ataggagaat aagcaactat atcatctttg
    21781 ttaatatgta cttttttatt taacttatta taaggtactt gttctaacaa aatagcacta
    21841 tttatcgctt ttgaagtcga agcataggca aatctcttat ctgaattaaa ttttacttcc
    21901 ttaccacttt tagtatctaa agcataaaca ccaatatgag cattatattt tttttctaaa
    21961 tcatttaact ctttggcatg tgaactgttt gaattacatg cacttaaaac taaagccatt
    22021 acaattaaaa atattaactt tttcaaaata aaccctccga tattacagtt gtaattttta
    22081 caaaacaata atattacaat tgtaatattg atgtcaattg tttattataa atatttgaaa
    22141 gaaggtgtca aaatggctaa attactaata atgagtgtag taagcttttg ttttatattt
    22201 ctattgttag tattttttag gtacatatta aaacgctatt ttaattatag tttaaattat
    22261 aaagtttggt atctaactgt gcttgctgga ttaattcctt ttatcccaat taaattctct
    22321 tttataaaat ttaataatgt gaataatcaa gcgcccacag ttgaaagtaa gtcacacgac
    22381 ttgaaccata acataattac caccaaacct gttcaagagt tcgcaacaga tatccataag
    22441 tttaattggg attcaattga taatatctgc acagttattt ggatagtttt agttattatt
    22501 ttaagtttta aatttttgaa agccttatta tatcttaaat atttaaagaa acagtcactt
    22561 tatctaaacg aaaatgaaaa aaataaaata gatacgatac ttttcaacca tcaatataaa
    22621 aaaaatattg tgattcgaaa agcagaggct attcaatctc caataacttt ttggtatggg
    22681 aaatatatta ttttgattcc tagttcatat tttaaaagtg taattgataa aagactaaaa
    22741 tatataatac tgcatgaata tgctcatgct aaaaatagag atactttaca tttaattatc
    22801 tttaatatct tctctattat tatgagttac aatccattag tacatattgt aaaaagaaag
    22861 ataattcatg acaatgaagt agaagccgat agatttgtcc ttaataatat taacaaaaat
    22921 gaatttaaaa cttatgcgga atctattatg gactccgtat taaaaacctc atttttcaac
    22981 aaaaatatat taagccattc atttaatggt aaaaaatcat tactcaaaaa tagattaatt
    23041 aatataaaag aagccgatct gaaaaagcag tcaaaattaa ttctaatttt tatttgtatt
    23101 tttacttttt ttatcatgat aattcaaagc cagtttttaa tggggcaatc cttaactgat
    23161 tataattata aaaagccctt acaaagcgat taccaaattt tagatgaaag taaaaatttt
    23221 ggttcaaata gtggatcttt cgttatgtac agcatgaaga aagacaaata ctatatttat
    23281 aatgaaaaag aaagtagaaa aagatattct cctgattcaa cttacaaaat ttatttagca
    23341 ctgtttggac ttgaccgtca tattataagt gataaaaatt cacgtatgtc atggaatcat
    23401 aaacattatc ttttcgagtc ttggaataag gaacaagatt taaatacagc aatgcaaaat
    23461 tcagttaatt ggtacttcga acgtattagt aatcaaatac caaagaacta tactgcggct
    23521 caactcaagc aattaaatta tggtaatgaa aatttgggaa gttataaaag ctattggatg
    23581 gaagatagtt tgaaaatatc taatcttgaa caagtaatag tttttaaaaa tatgatggaa
    23641 caaaataacc attttagtaa aaaagcaaag aatcaattat cttcttcatt attgattaag
    23701 aaaaatgaaa agtatgaact gtatgggaaa acaggtacag gtatagtaaa cgggaagtat
    23761 aataatgggt ggtttgtagg ttacgtaatt acaaatcatg ataagtatta ttttgctaca
    23821 catttatcag atggaaaccc gtctgggaaa aatgctgaat taataagtga aaaaatatta
    23881 aaaggaatgg gtgttttaaa tggccaataa gcaagttgaa atatctatgg ctgaatggga
    23941 tgttatgaat ataatatggg ataaaaaatc agtatcagct aatgaaattg tagttgaaat
    24001 tcaaaaatat aaagaagtta gtgataaaac gattagaaca ttaatcacaa gactatataa
    24061 aaaagagatt ataaaacgat acaaatcaga aaatatttat ttttactcat caaatattaa
    24121 agaagacgat attaaaatga aaactgctaa aacctttctt aataaactgt atggagggga
    24181 tatgaaaagt ttagtgttga attttgcgaa aaatgaagaa ttaaataaca aagaaattga
    24241 agaattgcga gatattttaa atgatattag taaaaagtaa ttagaggtat gtttcaaaca
    24301 taatacatat gtaaactatg cttgactctt attaaattag ttttgttaat gacatttaaa
    24361 atatattatt aaagatgaga gtgtacagaa aataaccatt ttctgtacac tcttctttta
    24421 tgtctaaata agtaagaatt acataggatt atgtgttcaa aaacccaaca aaaaatctat
    24481 gttcataaaa gaccttgtaa ttaagttatg gtacactgaa gatgtatata ggaggtttgt
    24541 attttgaaaa taggttatgc aagagtttca actggattac aaaatttaaa tttacaggag
    24601 gatcgattaa atacatatgg ttgtgaaaag atatttaatg accatatgag tggttcaaaa
    24661 agtaaaagac ctggtttaga taaagcaatt gaatttgcga ggtcaggaga tacgattgtt
    24721 gtttggagat tagatagatt gggacgtaat atggaggatt taatcacatt agttaatgag
    24781 cttaacgaac gaggtgtaag tttccatagt ttagaagaaa atataacaat ggataaatca
    24841 agttcaactg gacaattatt atttcattta ttcgcagcat ttgcagaatt tgaacgtaat
    24901 ttaattttag agcgttcttc agctggccga attgcagcac gtgctagagg ccgatatgga
    24961 ggcagaccag aaaaattaaa tcaaaaagat ttaaacttac ttaagaccct ttatgataat
    25021 ggcacgccaa ttaagacaat tgcagaacag tggcatgttt cacgtacaac aatttatcgt
    25081 tacctcaata aattggagga caaggaagat gaaaaacaag gagaagtatc taactaattt
    25141 ttctgaagcc aaacgtaaaa aagctactca aaagtacaat attataaaac cttttatcct
    25201 aggcgaacaa tctttatcaa gtatttctaa aagtaaaggg attgcgttaa gcacccttta
    25261 taggtggaat aagtcatata aagaacaagg acttaaagga ctaatctatg cgacaagagc
    25321 tgataaagga acacgtaaaa tagaaccaaa gataattgat gaaattgaac gccttgcgct
    25381 tatgaataaa agaaatagta tagccacaat tcataggaaa atcactaatt actgtaaaga
    25441 aaataatttt gatataccaa gttataaaca aatttatagt gttattaaag cgatgcctaa
    25501 gtctgttatt gatttctctc atcagggtga aaaatactat caaaataagt acgatttaat
    25561 acaaattaga gaatcctcga gacccaatga aatatggcaa gcagaccata ctttgctaga
    25621 tatctttata ttagaccaaa aaggtaatat caatagacca tggctaacta ttattatgga
    25681 tgactatagt cgtgcaattg caggctattt cttaagtttt gatgcccccc aatgctcaaa
    25741 acacagcatt aacactacac caagcaatat ggaataaaaa tgataccaat tggccagtgt
    25801 gtggtatacc cgaaaaattc tacacagatc atggaagtga ctttacttca catcatatgg
    25861 aacaagtcgc tattgatttg aaaattaact tgatgttttc gaaagttggt gttcctcgtg
    25921 gtcgtggaaa aatagaacga ttctttcaga cagttaatca aactttctta gaacaactgc
    25981 ctggatatat aaacaataat gatactccta gtaatctaat aaattttcac aattttgaag
    26041 aaaaattacg ttacttttta attgaagatt ataatcaaaa agaacatagt actattcata
    26101 ccacgcctat cagtcattgg aatagtaatc actttttccc taatatgcca agtagcttag
    26161 aacaacttga tttattattg ttggaaatac ctaaatctag aaaagttcat tcagatggca
    26221 ttcattttca aggttttcga tacagtaata ctaatctaga agcttatgta ggtgaatatg
    26281 tactgattcg ttataaccca aatgatatgg ctgaaatacg tgtgttttat agagatgaat
    26341 ttctttgtac tgctatatgt ccagaaatag ctgattactc catagatata aaagacatac
    26401 agcacgctcg tagtcagaga agaaaacact taaaacaaaa tattgctagt ccaagtacca
    26461 cggaattaat taaggaagaa aaaaattgtg gttattcacc tcaagaaacg actaaaaacg
    26521 tcaaaaaatt aaagagatat cgtaatgact aaaaatcaaa atttcattga aacgaaagag
    26581 tataaacgct ttgctgaatt ttgtgatgct tgtattaaat atcagtatat tggtatatgt
    26641 tatggtcaac ctggtgtcgg aaaaacttta tcgtctaggt attacacaaa ttgggatact
    26701 attgaaaaac aagttaacca tagaggttgg gaagatttag ctagtaaaac gaccgatgac
    26761 atactatcgg tggataaaat attttataat gcaccagcag aaaaacaaac taaattaagg
    26821 aatgatttat atagtattac tgcaatcatt gatttgggtc aaaaattaca tgttgtaaat
    26881 aagtatggac atgaacatag taaacattat agtgatatgt ttaaatatat tgatttaatt
    26941 atagtagatg agattgatcg ccttaaagtg caacatttag agcaattaag agctatttat
    27001 gatgaacata atttagcaat gatatttatt ggtatgccgg gtatagagaa aaaactatct
    27061 cgttatcctc aactatattc gcgtataggt tttgcgcatg aatttgataa tctaagtaaa
    27121 gatgagacgc atcatatatt agaatataag tggcaagact taggatttga tttaaaactc
    27181 gaagacttta ctgattatga ggcaataacg acgattatta aaattacaaa agggaatttt
    27241 aggctgattc atcgtttatt tgcgcagata gacagaatta tggatataaa tggtttagat
    27301 aaaataagta cagaagttgt agaaacagct agagatagtt tagttatagg tattcgataa
    27361 tagaaaaagc aacgcatttt aatatagtgc gttgcttttc tcatttatta ggtaaagtca
    27421 ttctcatata tcgagtaaag tgacaacaat tatatatgta tgattagggt gtaccacaag
    27481 tagacatata gacaaatatt tttacttttt agcgctttta acattatcaa aaggattatt
    27541 taacttatgt ttaatactaa ctatttatac ttattaaaat agagttaaat tttattgaaa
    27601 ggactcatta tgatggctat aaaatttata agacaatacg atgaaaagga ttgtggtcct
    27661 acttgccttg ccatgatttc acagttttat ggtaagcgtg tatctatccc acgtttgcgc
    27721 gaatatgcta aaacagataa attaggtaca aatttatatg gtctcgtaca agcaggtaaa
    27781 aagattggta ttgagttaac tggcgtaaaa gctgattcct ttgatgattt aaaacaagca
    27841 caattaccag ttatggtaca tattattaat caacaaggtt atgatcacta tatcattatt
    27901 gaaaaaataa aaaataacac gctttatatt gtcgatcctg ctaaaggtaa atataagtta
    27961 tcaagtactg aatttggaaa atattggact aatattgctg tattaattga taaaacagat
    28021 gattttacta ctgacaatga atcaccctcg tatcttaata tttttattga tatatttaaa
    28081 aataattatg gaaagttgtt atttattgct tttatctcac tatttattaa tattgttggt
    28141 attgtcgggg ctctatattt taaattatta accgatcata ttattccatc caatgttctt
    28201 aaaaatttac atattattag cttcggtatt ttacttttat acataatcaa tgcactcatt
    28261 aattatttaa ggtttcaact tatcttacat ttaagtttga aaatcgatgt taatttaatg
    28321 aaagattatt tttatcatgt tttacatctt ccgatgaact tttttgatac acgtaaatct
    28381 ggcgaaatcc tacaacgttt catggataca tctaaaattc gtgaagcttt atcatcttca
    28441 acggtaacgt tgctagttga tactttcatg attattatcg gtgctatatt actttatatg
    28501 caaagtcctt tgttactact gataacaatt atttttatac cttgttttat tatttgtagt
    28561 tacactttac gtaaaccttt tgaaaaatat aatcaaaagg tggctgaaaa agatgctgaa
    28621 ttgagttcat atttaataga atcctttgat ggtagtaata ctattaaaag ttatcaatct
    28681 gaagacgatc gtttctacat tggtactact aaatttaatg gtattattga aaacttatta
    28741 aaactgggta gattttctaa tatacaatta acggttaaca actttttaaa attaactatc
    28801 agtcttgtta tattgtggct tggtagttac ttagtcatga cggatagtat gacgttaggt
    28861 agtttattag cttttaatgc cttaactatt tattaccttg atcctattga acgtctcata
    28921 aatattcaac caacactgca atcttcattt gttgcagcac gtcgtattgc tgaaataact
    28981 gatttagaga ccgaaactga attatatact tctaaacaac cttatacttt taaaaacaac
    29041 attcgcattg aaaatgtaaa ctttcagtat ggctttcgaa gtgtggtatt gaaggatatt
    29101 aatttaaata ttaaaaaagg gcaaaaggtt gctattgttg gtgaaagtgg tagtggtaaa
    29161 tcaactatag gtaagttact caatcgctat tacactgctt cagaaggtaa tattatgatt
    29221 gataactata ttattgatga tattgatctt tctgacttac gtaagaatat aggctatgtt
    29281 tcacaaaaca cattcctttt tgctgataca attaaaaaca atcttttaca tggtagcaat
    29341 aaatacaaaa gtgatgaaga tatcgttaaa gcttgtcaat tagcagaatc cttagatttt
    29401 atacagaaat tcccagatca gtttaacact atgttagaaa aagaaggagc taatctatcg
    29461 ggcggacaag gccaacgctt atctttagca cgtacatttt taaaagatcc tgatatatat
    29521 attttcgatg aagctacaag tgccttagat agtttaactg aaaacaaaat tatggagcat
    29581 attgacttac taactcaaca tggtaaaacc gtaattatta tttcacataa attaagtact
    29641 ataaaaaatg ctgataatat ctatgtttta aacgagggtc aaattgctga gaatggtaca
    29701 catgatgagt tgattcattt aaacggtata tataaaaatt tatggcaact tcaaatgaaa
    29761 atagactgat tttatattaa tatactctat ttattaaata tatttcgata ataaaaaaaa
    29821 taaactcaaa aaaaagctca cttaactgtc tatttacatt ctctttatat tcaaatgcta
    29881 atttataaga tgtaagatga aattacttaa aggaggacta tttcaatgga aacactaaat
    29941 gaaaaacaat taaaagatat caatggtggt cgtgaaactg gttgttctgg tgattttgta
    30001 gaagatggaa taatgtgcaa tatcggacaa ggtattggta aagcaattaa taaagtacga
    30061 ggaaaataat ttaaaggagg actatttcaa tgaaaacact aaatgaaaaa caattaaaag
    30121 atatcaatgg tggtaaaggg attgttggtg aagtcactgg cgaagtcact agtattggta
    30181 atgccatttc aaatggttgg catgatttaa aacagtctgt cgctgatact acaaaatagg
    30241 actcattatt taaattaaaa aagtctgggt aataacccag acttttttaa ttgttcgact
    30301 ttaaataatt aaattatcta tatattattt taatataaca aaattaatta tcttattaag
    30361 gttatatgct attttttatt cttcttttat tctcttttct gtttttggtt gtagaatata
    30421 tagtatacgt gggttgagcg tatctgttgt catcttgtag ttgcttattt aaacacggta
    30481 attgtactac atatggatgc tcattatata atatcattaa tatagttaat gcttccccat
    30541 catttaataa tccctcttga ttttctttcc aatatttagc catttttgca tcttttattt
    30601 ttttaataac caatgatact gtttgcaatt atcgaagtta ctagtaaaaa gaaagtaata
    30661 gatgattata gacaataaaa agttttttga ttcttgttta tatattcttt actcgctttt
    30721 ttatcagtac cttctagcaa tacatcattt aacggaaaac taaattctga atacaaacac
    30781 ttaaatattt ctatactata acttatgata ctactcaaag atacccattt tttaatataa
    30841 gtgttttgca ttcttctact aaccagtgtt ataatttaga caacaagagc ttcgtacatt
    30901 atatgcacca atcccctcac tactcgcaat agtgagggga tttttaggtg ttggctaata
    30961 tcgcctattt tttcttattg ttacgtgtac gtagccaatg cgtaaataac gcaacaatac
    31021 aaccactgat gactgtggtc gtgatgtgaa caagagcttc gaccatctga tatgcacctc
    31081 ctctctgcgt ctaaattgac gcctgagaga taggcgacct gtatattata tcatctctga
    31141 ataagggata atagataact tccgataagt cattttatgt tatatctttg cttttttata
    31201 gtatcaagac aagaagaaac tcgtttcact cgtttcaaaa accctcctga tttttagaga
    31261 aaaattcttt tatttcatcg tctttaataa aataatatgc catctttccc tttttataaa
    31321 aatcaagtac atcattttta tataaaagtc ttaaatgatg tgaagttgaa gcaacactta
    31381 ttttcaatat caaagaaata tcacaaacac acaactcatc ttctttaatc aaagataata
    31441 tgattttcaa tttcttctca tcacaaattt tttctaaaat gttaagtaat ttcttagatt
    31501 tatcatcttc taaaaaactt aaagcattgt taactttatc ctcatgtaca cagatcacat
    31561 cacaagcatt ttcataactc atataaaatc gcaccctaaa ttaaaatata aatcctaaaa
    31621 ttgtttgaat agtatcattt tcaataataa taaataaacc taaagctata taaataacag
    31681 ccataatcca acgactaaat ttctcaacaa tttctccaac tcctggaata ttagataatt
    31741 tttgtgcagt aaataccaag aagaaaatta aaattaaaaa gacaaacaga gtaattaata
    31801 aattagtaac acttaatgtc acaaaatacg gaacaaataa accaatatta tcagcaccac
    31861 aacttgctat cgtaacaatt gcaaccgtac caactaattt agacaatcct ttttcattca
    31921 attctttttt agctctcttt tctccttcac aatcatcata aatagctact ttaattccta
    31981 aataaatcgg tattaaccct aataatccta atatccattt ttcaggaaca taatttaaga
    32041 caaaggcaaa gaataaactt acgacaatca atgccacaga tcctacatat tgaccaatat
    32101 aaatatctcg atattctttc ttagtctttg ctctagcaaa aaatattaat aaaatcacta
    32161 ataaatctac tgctgtcgca atataaagaa tagcagcagt tacaatagtc tgaatcataa
    32221 ttacacctca ttcaaaaata tttttgaatg tattataact tatgttttca aataatcata
    32281 gatgctttat tccaattgct ttattgacgt tgagcctcgg aacccttaac aatcccaaaa
    32341 cttgtcgaat ggtcggctta atagctcacg ctatgccgac attcgtctcc aagtttagtt
    32401 aagggttctt ctcaacgcac aataaatttt ctcggcataa atgccgtgtt ataattaaaa
    32461 tacttttggt tctgttgcaa agtaaaaaat atagctaatc actaatatat catgtcagtg
    32521 ttcgtttaac ttgctagcat gatgctaatt tcgtggcatg gggaaaatcc gtagatctga
    32581 agagacctac gg
//
