LOCUS       CP152327               23090 bp    DNA     circular BCT 29-APR-2024
DEFINITION  Staphylococcus aureus strain BSN134 plasmid pUSA04, complete
            sequence.
ACCESSION   CP152327
VERSION     CP152327.1
DBLINK      BioProject: PRJNA1048360
            BioSample: SAMN38637713
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 23090)
  AUTHORS   Berti,A.D., Gurdziel,K. and Liu,W.
  TITLE     Pre-publication release of Staphylococcus aureus str BSN134 whole
            genome sequence
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 23090)
  AUTHORS   Berti,A.D., Gurdziel,K. and Liu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2024) Pharmacy Practice, Wayne State University,
            259 Mack Ave, Detroit, MI 48201, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2024
            Assembly Method                   :: SPAdes v. FEB-2024
            Assembly Name                     :: BSN134
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: CP043386, CP014442, CP014445
            Genome Coverage                   :: 179.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/23/2024 11:38:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,997
            CDSs (total)                      :: 2,915
            Genes (coding)                    :: 2,831
            CDSs (with protein)               :: 2,831
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 84
            CDSs (without protein)            :: 84
            Pseudo Genes (ambiguous residues) :: 0 of 84
            Pseudo Genes (frameshifted)       :: 44 of 84
            Pseudo Genes (incomplete)         :: 44 of 84
            Pseudo Genes (internal stop)      :: 16 of 84
            Pseudo Genes (multiple problems)  :: 19 of 84
            ##Genome-Annotation-Data-END##
            Bacteria and source DNA available from Andrew D. Berti, Wayne State
            University, Detroit MI  USA.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..23090
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="BSN134"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pUSA04"
                     /geo_loc_name="USA: Detroit, MI"
                     /lat_lon="42.33 N 83.05 W"
                     /collection_date="2021-09-28"
                     /collected_by="Andrew D. Berti"
     gene            join(22881..23090,1..465)
                     /locus_tag="UXR16_14855"
     CDS             join(22881..23090,1..465)
                     /locus_tag="UXR16_14855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004803 - transposase activity [Evidence IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="XAE35763.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            606..1241
                     /locus_tag="UXR16_14860"
                     /pseudo=""
     CDS             606..1241
                     /locus_tag="UXR16_14860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009251744.1"
                     /note="internal stop; incomplete; partial on complete
                     genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /name="aminoglycoside 6-adenylyltransferase"
     gene            1238..1768
                     /gene="sat4"
                     /locus_tag="UXR16_14865"
     ARG             1239..1765
                     /name="sat4"
                     /gene="sat4"
                     /gene_name="streptothricin N-acetyltransferase Sat4"
                     /tool="amrfinderplus"
                     /drug_class="STREPTOTHRICIN"
                     /identity="97.78"
                     /coverage="100.0"
     gene            1861..2655
                     /gene="aph(3')-IIIa"
                     /locus_tag="UXR16_14870"
     ARG             1862..2652
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            3137..3612
                     /locus_tag="UXR16_14875"
                     /pseudo=""
     CDS             3137..3612
                     /locus_tag="UXR16_14875"
                     /inference="COORDINATES: protein motif:HMM:NF024676.4"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="WYL domain-containing protein"
                     /name="WYL domain-containing protein"
     gene            complement(3671..4345)
                     /locus_tag="UXR16_14880"
     CDS             complement(3671..4345)
                     /locus_tag="UXR16_14880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004803 - transposase activity [Evidence IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="XAE35766.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            4607..4792
                     /locus_tag="UXR16_14885"
     CDS             4607..4792
                     /locus_tag="UXR16_14885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="XAE35767.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            complement(5015..5593)
                     /locus_tag="UXR16_14890"
     CDS             complement(5015..5593)
                     /locus_tag="UXR16_14890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="XAE35768.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(5858..6238)
                     /gene="blaI"
                     /locus_tag="UXR16_14895"
     ARG             complement(5862..6238)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.41"
                     /coverage="100.0"
     gene            complement(6228..7985)
                     /gene="blaR1"
                     /locus_tag="UXR16_14900"
     ARG             complement(6232..7985)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.38"
                     /coverage="100.0"
     gene            8092..8937
                     /gene="blaZ"
                     /locus_tag="UXR16_14905"
     ARG             8093..8934
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(9463..9882)
                     /locus_tag="UXR16_14910"
     CDS             complement(9463..9882)
                     /locus_tag="UXR16_14910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="XAE35772.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            10006..10977
                     /locus_tag="UXR16_14915"
     CDS             10006..10977
                     /locus_tag="UXR16_14915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="XAE35773.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(11149..11241)
                     /locus_tag="UXR16_14920"
     CDS             complement(11149..11241)
                     /locus_tag="UXR16_14920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="XAE35774.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(11398..11745)
                     /locus_tag="UXR16_14925"
     CDS             complement(11398..11745)
                     /locus_tag="UXR16_14925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]; GO_process: GO:0006355 - regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="XAE35775.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(11764..12381)
                     /gene="cadD"
                     /locus_tag="UXR16_14930"
     ARG             complement(11768..12381)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(13497..13691)
                     /locus_tag="UXR16_14935"
     CDS             complement(13497..13691)
                     /locus_tag="UXR16_14935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="XAE35753.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            13801..14493
                     /locus_tag="UXR16_14940"
     CDS             13801..14493
                     /locus_tag="UXR16_14940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative immunity/bacteriocin fusion bifunctional
                     protein"
                     /protein_id="XAE35754.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="putative immunity/bacteriocin fusion bifunctional
                     protein"
     gene            complement(14661..14810)
                     /locus_tag="UXR16_14945"
     CDS             complement(14661..14810)
                     /locus_tag="UXR16_14945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="XAE35755.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(15386..15676)
                     /locus_tag="UXR16_14950"
                     /pseudo=""
     CDS             complement(15386..15676)
                     /locus_tag="UXR16_14950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009384749.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(15696..16679)
                     /locus_tag="UXR16_14955"
     CDS             complement(15696..16679)
                     /locus_tag="UXR16_14955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="XAE35756.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFENRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            17105..17848
                     /locus_tag="UXR16_14960"
     CDS             17105..17848
                     /locus_tag="UXR16_14960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="XAE35757.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(18075..18260)
                     /locus_tag="UXR16_14965"
     CDS             complement(18075..18260)
                     /locus_tag="UXR16_14965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="XAE35758.1"
                     /translation="MKNRIREYRKQKGISQETLSKELKVSRQTINAIENNKYDPTLTLA
                     FKLARLFDTTVDELFS"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(18265..18603)
                     /locus_tag="UXR16_14970"
     CDS             complement(18265..18603)
                     /locus_tag="UXR16_14970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="XAE35759.1"
                     /translation="MNLIPFIIILIFSCLWTAITNKYLPSETLDKKGQQDRYDERQRKM
                     FIEILAKSFIWIVYCMLFTLVLKFTGLSPSIEGSWFSQYPEIFFIIVALFLMLFNYYTT
                     NKKYTSKG"
                     /name="hypothetical protein"
     gene            complement(18849..19457)
                     /locus_tag="UXR16_14975"
     CDS             complement(18849..19457)
                     /locus_tag="UXR16_14975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="XAE35760.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTFGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKDVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGKAISKIAKEVNITRQTVYRIKHDKGLS"
                     /name="recombinase family protein"
     gene            complement(19943..20842)
                     /locus_tag="UXR16_14980"
     CDS             complement(19943..20842)
                     /locus_tag="UXR16_14980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000196697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mph(C) family macrolide 2'-phosphotransferase"
                     /protein_id="XAE35761.1"
                     /translation="MTRHNEIIKCAEKYQLHIQPQTISLNESGLDFQVAFGKDKHGVEW
                     VLRLPRRPDVYKRTKPEKQTVDFLQKNVSFEIPKWKVHAKDLIAYPKLTGKPAATIDPE
                     IQNYVWEIEHKPLPENFINTLAETLVDLHNIPEENINVQHINIKTIQEIKNDFQRRMNK
                     VKETYGVSDELWNRWKQWLENDELWPRHATMIHGDLHPGHIMVDNQANVTGLIDWTEAT
                     HSDPSMDFIGHHRVFDDEGLEQLITAYGKAGGEIWPRMKEHIIELNAVFPMFIAEFAME
                     SGESAYETMALKELGMKE"
                     /name="Mph(C) family macrolide 2'-phosphotransferase"
     gene            complement(20941..22407)
                     /gene="msr(A)"
                     /locus_tag="UXR16_14985"
     ARG             complement(20945..22407)
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(19947..20842)
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(20942..22407)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             complement(19944..20842)
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             1251..1768
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="97.16"
                     /coverage="95.56"
     ARG             643..944
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.0"
                     /coverage="36.23"
     ARG             8093..8937
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     Typing          complement(15152..15316)
                     /name="MOB_unknown"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="2.42e-81"
     Typing          complement(15389..15565)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="93.82"
                     /coverage="94.0"
                     /evalue="1.33e-69"
     Typing          complement(15697..16679)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.593"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          17106..17848
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 tacaaatggc gtattgatga gacgtatatc aaaataaaag gaaaatggag ctatttatat
       61 cgtgccattg atacagaggg acatacatta gatatttggt tgcgtaagca acgagataat
      121 cattcagcat atgcgtttat caaacgtctc attaaacaat ttggtaaacc tcaaaaggta
      181 attacagatc aggcaccttc aacgaaggta gcaatggtta aagtaattaa agcttttaaa
      241 cttaaacctg actgccattg tacatcgaaa tatctgaata acctcattga gcaagatcac
      301 cgtcatatta aagtaagaaa gacaaggtat caaagtatca atacagcaaa gaatacttta
      361 aaaggtattg agtgtattta cgctctatat aaaaagaacc gcaggtctct tcagatctac
      421 ggattttcgc catgccacga aattagcatc atgctagcaa gttaaacgaa cactgacatg
      481 atatattagt gattagctat attttttact ttgcaacaga accatcattt ttattaaaat
      541 actcttttgt aaaatctttc tgctcttcaa tgtatttaat ttctttacct ctaaatctat
      601 tatagctatt tgatgattac aataaaattg atcttacctt attgcccttg gaagagttag
      661 ataattacct aaagggcgat aaattaataa aggttctaat tgataaagat tgtagaatta
      721 aaagggacat agttccgact gatatagatt atcatgtaag aaagccaagc gcaagggagt
      781 atgatgattg ctgcaatgaa ttttggaatg taacacctta tgttattaaa ggattgtgcc
      841 gtaaggaaat tttatttgct attgatcatt ttaatcagat tgttcgccat gagctgctga
      901 gaatgatatc atggaaggtc ggcatcgaaa caggctttaa atgaagtgta ggcaagaact
      961 ataagtttat tgaaaggtat atatccgagg atttgtggga gaaacttttg tccacctacc
     1021 ggatggattc ctatgaaaac atatgggaag cattatttct atgccatcaa ttgttcaggg
     1081 cggtatccgg tgaggtggcg gaaaggcttc attatgccta tccggagtat gataggaata
     1141 taacaaaata taccagggac atgtataaaa aatacactgg taaaaccggc tgcctggata
     1201 gcacatatgc cgctgatata gaagagaggc gggaacagtg attacagaaa tgaaagcagg
     1261 gcacctgaaa gatatcgata aacccagcga accatttgag gtgataggta agattatacc
     1321 gaggtatgaa aacgagaatt ggacctttac agaattactc tatgaagcgc catatttaaa
     1381 aagctaccaa gacgaagagg atgaagagga tgaggaggca gattgccttg aatatattga
     1441 caatactgat aagataatat atctttacta ccaagacgat aaatgcgtcg gaaaagttaa
     1501 actgcgaaaa aattggaacc ggtacgctta tatagaagat atcgccgtat gtaaggattt
     1561 cagggggcaa ggcataggca gcgcgcttat caatatatct atagaatggg caaagcataa
     1621 aaacttgcat ggactaatgc ttgaaaccca ggacaataac cttatagctt gtaaattcta
     1681 tcataattgt ggtttcaaaa tcggctccgt cgatactatg ttatacgcca actttgaaaa
     1741 agctgttttc tggtatttaa ggttttagaa tgcaaggaac agtgaattgg agttcgtctt
     1801 gttataatta gcttcttggg gtatctttaa atactgtaga aaagaggaag gaaataataa
     1861 atggctaaaa tgagaatatc accggaattg aaaaaactga tcgaaaaata ccgctgcgta
     1921 aaagatacgg aaggaatgtc tcctgctaag gtatataagc tggtgggaga aaatgaaaac
     1981 ctatatttaa aaatgacgga cagccggtat aaagggacca cctatgatgt ggaacgggaa
     2041 aaggacatga tgctatggct ggaaggaaag ctgcctgttc caaaggtcct gcactttgaa
     2101 cggcatgatg gctggagcaa tctgctcatg agtgaggccg atggcgtcct ttgctcggaa
     2161 gagtatgaag atgaacaaag ccctgaaaag attatcgagc tgtatgcgga gtgcatcagg
     2221 ctctttcact ccatcgacat atcggattgt ccctatacga atagcttaga cagccgctta
     2281 gccgaattgg attacttact gaataacgat ctggccgatg tggattgcga aaactgggaa
     2341 gaagacactc catttaaaga tccgcgcgag ctgtatgatt ttttaaagac ggaaaagccc
     2401 gaagaggaac ttgtcttttc ccacggcgac ctgggagaca gcaacatctt tgtgaaagat
     2461 ggcaaagtaa gtggctttat tgatcttggg agaagcggca gggcggacaa gtggtatgac
     2521 attgccttct gcgtccggtc gatcagggag gatatcgggg aagaacagta tgtcgagcta
     2581 ttttttgact tactggggat caagcctgat tgggagaaaa taaaatatta tattttactg
     2641 gatgaattgt tttagtacct agatttagat gtctaaaaag ctttaactac aagcttttta
     2701 gacatctaat cttttctgaa gtacatccgc aactgtccat actctgatgt tttatatctt
     2761 ttctaaaagt tcgctagata gagttctata ttagagatgt aaagagtttt ggtgaagagg
     2821 tttgtgagta tggcttttat aaccagggtg caatgagaag cactaacagc agctagctta
     2881 agaacgcata ggatatactt tttatggaag tcacagagga ggaataaaat ttgaacagga
     2941 ttaacagagt aacctctatt cttattcagc tgcaatcaaa aaaataattc ctgccaaaga
     3001 aattgcacag cgatttaata taagcttaag gacagtttac agagatatcc ggacacttga
     3061 agaagccgga ataccaattg gatctgaggc cggaaaagga tattttcttg tagagggctt
     3121 cctacttctg ccggtaatgt ttacagcggc ggaagtgggt gcattgatta cagcagggaa
     3181 atttttaaat tgccatggag atgaatcatt tataaaggat tttgattcag ctatgtataa
     3241 aatcaaatct attttgaagc atggtgaaaa aaactatgca caggagttgg agaacagtat
     3301 taacgtgtac agcacatctg gacagaaaaa tacattggcg gataacgtta ttgcagcaat
     3361 tcagactgca atctgcaata aaagggtaat atcaattcaa tatcctgcat caggagggca
     3421 agaaccggaa agcagaatga tagagcctat atcactgggg ttttatgaac agaactggta
     3481 cttaatcggt tttgcaggct aagaaatgaa tataggaatt ttcgtgtgga tcggattaaa
     3541 agcatttgca tagaagaaga gctctgtcaa agccatgatg gctctttgga acaaatatta
     3601 aaacaaatgc tggttctgtt gcaaagtaaa aaaatatagc taaccactaa tttatcatgt
     3661 cagtgttcgc ttaacttgct agcatgatgc taatttcgtg gcatggcgaa aatccgtaga
     3721 tctgaagaga cctgcggttc tttttatata gagcgtaaat acactcaata ccttttaaag
     3781 tattctttgc tgtattgata ctttgatacc ttgtctttct tactttaata tgacggtgat
     3841 cttgctcaat gaggttattc agatatttcg atgtacaatg gcagtcaggt ttaagtttaa
     3901 aagctttaat tactttaacc attgctacct tcgttgaagg tgcctgatct gtaattacct
     3961 tttgaggttt accaaattgt ttaatgagac gtttgataaa cgcatatgct gaatgattat
     4021 ctcgttgctt acgcaaccaa atatctaatg tatgtccctc tgcatcaatg gcacgatata
     4081 aatagctcca ttttcctttt attttgatgt acgtctcatc aatacgccat ttgtaataag
     4141 cttttttatg ctttttcttc caaatttgat ataaaattgg ggcatattct tgaacccaac
     4201 ggtagaccgt tgaatgatga acgtttacac cacgttccct taatatttca gatatatcac
     4261 gataactcaa tgcatatctt agatagtagc caacagctac agtgataaca tccttgttaa
     4321 attgtttata tctgaaatag ttcatacaga agactccttt ttgttaaaat tatactataa
     4381 attcaacttt gcaacagaac ctcatttact atatgggcat ctctttcatt attaatacaa
     4441 agctttgtat ctccgatatt aggcaaaggt gtaaacgaat taggtgatac tataggattc
     4501 aacattatat taatcgtttc tttaataatg attatcttct tattttttat aaatcgtagt
     4561 aaaaatatct cctatgatta tataaaagtt caaagaggtg aagccaatga ataaattaga
     4621 aaaatggtct ttggtattta ttatttttac atttctctct tcattagcac ttttatattt
     4681 caaatataat tttagttcgg ttatgccagt cctaagtctt tctattttaa ctatactaat
     4741 attgttgacg agtattatta ctgtagtttc agttaatgat gaagatactt aaaacgttca
     4801 ttagtgaaac aggtattata ttaaaaaagc gtacgaattt gtacgctttt ttcttgtgtt
     4861 attattaaaa tctcataaca ggaaaatatt atgagatttt agacgctgtc agaacgtctc
     4921 ttttacatcg agtgacattg aatcaaagtc tttgtatgtt aatgatatat aaaattattt
     4981 agtagattca ttatagtaag ctagattagt tgctctactt gtttttattc tcttttgcct
     5041 ctaatttatt gagataacga taaatagttg tacgtgaaac ttgccactgc tctgcaattg
     5101 ttttaattgg cgtaccatta tcataaagtg tcttaagtaa gtttaaatct tgtttattta
     5161 atttttcagg tctacctcca tatcggcctc tagcacgtgc tgcaattcga ccggctgatg
     5221 atcgctctaa aattaaatta cgttcaaact ctgcaaatgc tgcgaataaa tgaaataata
     5281 attgtcctgt agaacttgat ttatccatcg ttatattttc ttctaaacta tgaaaactca
     5341 cacctcgttc gttaagttca ttaactaacg tgattaaatc ctccatgttc cgtcctagtc
     5401 tatctaatct ccaaacaaca atcgtatctc ctgacctcgc aaattcaatt gctttatcta
     5461 aaccaggtcg cttacttttt gaaccactca tatggtcatt aaatatcttt tcacaaccat
     5521 atgtatttaa tcgatcctcc tgtaaattca aattttgtaa tccagttgaa actcttgcat
     5581 aacctatttt caaaatacag acctcctata tacaccttta gtgtaccata acttgattac
     5641 gaggtctttt gtgaacatag attttttgtt gggtttttga acacataatt ctatgtaata
     5701 cttacttatt tagacaaaaa acaagagtgt acagaaaatg ggttattttc tggacactct
     5761 catctttaat aatatatttt aaatgtcatt aacaaaacta atttaataag agtcaagtat
     5821 ggtttacata tgtattatgt ttgaaacata cctctaatta ctttttacta atatcattta
     5881 aaatgtctcg caattcttca atttctttgt tatttaattc ttcatttttc gcaaaattca
     5941 gcactaaact tttcatatcc cctccataca gtttattaag aaaggtttta gcagttttca
     6001 ttttaatatc gtcttcttta atatttgatg agtaaaaata aatattttct gatttgtatc
     6061 gttttataat ctctttttta tatagtcttg tgattaatgt tctaatcgtt ttatcactaa
     6121 cttctttata tttttgaatt tcaactacaa tttcattagc tgatactgat tttttatccc
     6181 atattatatt cataacatcc cattcagcca tagatatttc aacttgctta ttggtcattt
     6241 aaaacaccca ttccttttaa tattttttca cttattaatt cagcattttt cccagacggg
     6301 tttccatctg ataaatgtgt agcaaaataa tacttatcat gatttgtaat tacgtaacct
     6361 acaaaccacc cattattata cttcccgttt actatacctg tacctgtttt cccatacagt
     6421 tcatactttt catttttctt aatcaataat gaagaagata attgattctt tgctttttta
     6481 ctaaaatggt tattttgttc catcatattt ttaaaaacta ttacttgttc aagattagat
     6541 attttcaaac tatcttccat ccaatagctt ttataacttc ccaaattttc attaccataa
     6601 tttaattgct tgagttgagc cgcagtatag ttctttggta tttgattact aatacgttcg
     6661 aagtaccaat taactgaatt ttgcattgct gtatttaaat cttgttcctt attccaagac
     6721 tcgaaaagat aatgtttatg attccatgac atacgtgaat ttttatcact tataatatga
     6781 cggtcaagtc caaacagtgc taaataaatt ttgtaagttg aatcaggaga atatcttttt
     6841 ctactttctt tttcattata aatatagtat ttgtctttct tcatgctgta cataacgaaa
     6901 gatccactat ttgaaccaaa atttttactt tcatctaaaa tttggtaatc gctttgtaag
     6961 ggctttttat aattataatc agttaaggat tgccccatta aaaactggct ttgaattatc
     7021 atgataaaaa aagtaaaaat acaaataaaa attagaatta attttgactg ctttttcaga
     7081 tcggcttctt ttatattaat taatctactt ttgagtaatg attttttacc attaaatgaa
     7141 tggcttaata tatttttgtt ggaaaatggg gtttttaata cggagtccat aatagattcc
     7201 gcataagttt taaattcatt tttgttaata ttattaagga caaatctatc ggcttctact
     7261 tcattgtcat gaattatctt tctttttaca atatgtacta atggattgta actcataata
     7321 atagagaaga tattaaagat aattaaatgt aaagtatctc tatttttagc atgagcatat
     7381 tcatgcagta ttatatattt tagtctttta tcaattacac ttttaaaata tgaactagga
     7441 atcaaaataa tatatttccc ataccaaaaa gttattggag attgaatagc ctctgctttt
     7501 cgaatcacaa tatttttttt atattgatgg ttgaaaagta tcgtatctat tttatttttt
     7561 tcattttcgt ttagataaag tgactgtttc tttaaatatt taagatataa taaggctttc
     7621 aaaaatttaa aacttaaaat aataactaaa actatccaaa taactgtgca gatattatca
     7681 attgaatccc aattaaactt atggatatct gttgtgaact cttgaatagg tttggtggta
     7741 tttatgttat ggttcaaatc gtgtgactta ctttcaactg tgggcgcttg attattcaca
     7801 ttattaaatt ttataaaaga gaatttaatt gggataaaag gaattaatcc agcaagcata
     7861 gttagatacc aaactttata atttaaacta taattaaaat agcgttttaa tatgtaccta
     7921 aaaaatacta acaatagaaa tataaaacaa aagcttacta cgctcattat tagtaattta
     7981 gccattttga caccttcttt caaatattta taataaacaa ttgacatcaa tattacaatt
     8041 gtaatattat tgatttataa aaattacaac tgtaatatcg gagggtttat tttgaaaaag
     8101 ttaatatttt taattgtaat tgctttagtt ttaagtgcat gtaattcaaa cagttcacat
     8161 gccaaagagt taaatgattt agaaaaaaaa tataatgctc atattggtgt ttatgcttta
     8221 aatactaaaa gtggtaagga agtaaaattt aattcagata agagatttgc ctatgcttcg
     8281 acttcaaaag cgataaatag tgctattttg ttagaacaag taccttataa taagttaaat
     8341 aaaaaagtac atattaacaa agatgatata gttgcttatt ctcctatttt agaaaaatat
     8401 gtaggaaaag atatcacttt aaaagaactt attgaggctt caatgacata tagtgataat
     8461 acagcaaaca ataaaattat aaaagaaatc ggtggaatca aaaaagttaa acaacgtcta
     8521 aaagaactag gagataaagt aacaaatcca gttagatatg agatagaatt aaattactat
     8581 tcaccaaaga gcaaaaaaga tacttcaacg cctgctgctt tcggcaagac tttaaataaa
     8641 cttatcgcaa atggaaaatt aagcaaaaaa aataaaaatt tcttacttga tttaatgttt
     8701 aataataaaa acggagacac tttaattaaa gatggtgttc caaaagacta taaggttgct
     8761 gataaaagtg gtcaagcaat aacatatgct tctagaaatg atgttgcttt tgtttatcct
     8821 aagggccaat ctgaacctat tgttttagtc atttttacga ataaagacaa taaaagtgat
     8881 aagccaaatg ataagttgat aagtgaaacc gccaagagtg taatgaagga attttaatat
     8941 tctaaatgca taataaatac tgataacatc ttatagtttg tattatattt tgtattatcg
     9001 ttgacatgta taattttgat atcaaaaact gattttccct ttattatttt cgagatttat
     9061 tttcttaatt ctctttaaca aactagaaat attgtatata caaaaaatca taaataatag
     9121 atgaatagtt taattatagg tgttcatcaa tcgaaaaagc aacgtatctt atttaaagtg
     9181 cgttgctttt ttctcattta taaggttaaa taattctcat atatcaagca aagtgacaat
     9241 agcattttac aagtattttt tattgttcga ttagggtaaa cctaaataat acataaatta
     9301 tattacaata tgtttattat agaggctaaa gtatcttaga aatttggata gtaggttttt
     9361 cgggaataaa agtatagttg gctttaatat ataattaagc taagctatca tttatattta
     9421 ctcgattata attcgcactt caactttttt ataacgtaaa aattaaaacg tagttttatt
     9481 tatctttagt aatatctttt taaacactac agtttcttca ttagttaaat tagcgaagta
     9541 atgattatta agttgatagg ctttcttttc taatgttggc cataagtctt ttgctttatt
     9601 tgtactgttt attagcacag ttcttctatt ttcattatca gtttgacgtg ttattagatc
     9661 ctttttggac atcttatcta atattccaga tattgttgaa ggttctaaat ttaaagtatt
     9721 accaatcgct ttaggtgtat tcaaattact attaatcaag caattcaaaa caccatattc
     9781 tgctggagta atattatagg gacttaataa acttttaaaa tgtttaaaaa ctctattctg
     9841 agaagtactc aacaaataat ttatacaatt atctaattcc acaactaaaa cctctcttaa
     9901 atcattagta ttgactcgct tatcatatca tgataagttt tgtaggaaaa tagttttgca
     9961 acaaaaacat acttctacaa aacaattgtg aaagaaggct aataaatgtt caatgcggta
    10021 gtagtgagaa aaagtgcatc aaatgttagt tataaagtag aaaaagttga tgaatctcat
    10081 ttatcgaagg gtgatgtatt agtaaaagtg gtatactctt caataaatta taaggatatg
    10141 ctagctttac aatataaagg cggtgtaatt agagattatc ctatgattcc tggtatagat
    10201 tttgcaggta ttgttgaatc aagttcgaat gataagttta aagaaggcga taatgtatta
    10261 gttactggtt atgatgttgg cgtgacacat acaggtggat tttcagaata tgcacaagtg
    10321 cctggagagt ggattgttcc tattccccaa gaaatgtcta ttaaagagtc tatggtatat
    10381 ggcacagccg gttttacggc agcattatca atttttgaac tagaaaaata tggaatgaat
    10441 atcaaatcac aacctgaaat tttagtgtct ggggctacag gtggtgtggg cagtgttgct
    10501 atacaaattt tacataaaat tggatatgaa aatatcactg ctatcgtaag aaaagaaaag
    10561 caaatagaaa tcgcaaaaaa attaggtgca aaacaagtaa taataattga agatgataat
    10621 aaaccgctta aaaaaggtat ttttgattat ttcttagata cagtggggag taatgtaaca
    10681 ttatacggtt taaaacgtct aaattatcaa ggtgttgcta ctgtatgtgg aaatgtagca
    10741 ggaaattcac ttaacgctaa tatattaccg tttattctta gaggtattaa attaattggc
    10801 attgattctg tatatgttga tcataatatc cgtgaagata tatggagtaa gttagcaaat
    10861 gaatggaata taggaaattc acttctatac aatgaaattg gatttgaaga attctataaa
    10921 acgatagatc agcttttaaa aggacaacat ttaggaagaa ctattttaaa agtataagtg
    10981 tgagtattca ttaatacatt tactattaat tcaatcattt tgcatttctc tactaaccag
    11041 tgttataatt tatataacga aaatgattaa caattaatgc accaatcccc acactattgc
    11101 agtagtgtgg ggattttttc gatgctggct tataaagtcg cctattaatt atttgttgcg
    11161 tttactaagc caataagtat aatacgcaac agcacagcca ctgatgactg gtgctatgat
    11221 gtgaacgaaa atgattagca aagtaatgca cctcctctct tcgtcaattg acgcctgaga
    11281 gataggcgac tctattatta taccatctgt gaatatacaa gcatatctac ttccgataag
    11341 tcgtcttatg ttatataact ttgtttttta tagtatcaag acaagaagaa actcgtttca
    11401 aaaaccctca tgatttttag agaaaaactc tcttatttca tcgtctttaa taaaataata
    11461 tgccatcttt ccatctttat aaaaatcaag tacctcattt ttatataaaa gccttaaatg
    11521 atgtgaagtt gaagcaacac tcattttcaa tatcaaagaa atatcacaaa cacacaactc
    11581 atcttcttta atcaaagata atatgatttt caatttcttc tcatcacaaa ttttttctaa
    11641 aatgttaagt aatttcttag atttatcatc ttctaaaaaa cttaaagcat tgttaacttt
    11701 atcctcatgt acacagatca catcacaagt attttcataa ctcatataaa atcacaccct
    11761 aaattaaaat ataaatccta aaattgtttg aatagtgtca ttttcaataa taataaataa
    11821 acctaaagct atataaataa tagccataat ccaacgacta aatttctcaa caatttctcc
    11881 aattcctgga atattagcta atttttgtgc agtaaacacc aagaagaaaa ttaaaattaa
    11941 aaagacaaac agagtaagta ataaattagt aacacttaat gtcacaaaat acggaacaaa
    12001 taaaccaata ttatcggcgc cacaacttgc tatcgtaaca attgcaaccg taccaactaa
    12061 tttagacaat cctttttcat tcaattcttt tttagctctc ttttctcctt cacaatcatc
    12121 ataaatagcc actttaattc caagataaat tggtattaaa cccaataaac ctaatatcca
    12181 cttttctgga acataattta atacaaaagc taaaaacaaa ctaactaata ttaaaataat
    12241 agaccctaaa tattgaccaa cataaatatc tctatattct tttctagtct ttgctctagc
    12301 aaaaaatatt aataaaatta ctaataaatc aactgctgta gcaatataaa gaacagcagc
    12361 agcaacaacc gtttgaatca taatacacct cattcaaaaa tatttttgaa tgtattataa
    12421 cttatatttt taaataatca taggtgcttt attccaattg ctttattgac gttgagcctc
    12481 ggaaccctta acaatcccaa aacttgtcga atggtcggct taatagctca cgctatgccg
    12541 acattcgtct gcaagtttag ttaagggttc ttctcaacat caataaattt tttcggcata
    12601 aatgcgtgtc tatgcgtaga catggagaca cttcagaatt atggagtgat tacatgagtt
    12661 taactatttt tctttattca gttttaggaa gtttattagc aaattatatc tacgaaaaat
    12721 cttcaaaata aataactttt tcggttctac tttgtacact ttatctacct ggtagaccta
    12781 attgttattg ctttacaggt ctaaaattcg tcgttataat ctagttaaat cccgtaaggg
    12841 cgcacttata cgtcggataa atcgacatgt gcaaaaacgt aatcgacctt cgtcgatttt
    12901 tttatttcaa aattaaagaa acggcttgag atattccgag cagttataaa aattaatttg
    12961 cgttgaatat tgctactaca ttcttgaaaa agtgatgtag atttatagcc cataactttt
    13021 ttgaattaca tcgacgatac ggcgtcgaaa gaaaaataaa tagaccgtat gaaagaaaaa
    13081 gctacctcac tttatctggg gtagctttta ttttttatgc ccttattttg aattttaaga
    13141 gggcatttta aagatttagg ggtgattcat atagttttat atctaaaact tatatatgct
    13201 tttaaaacgc aaatatgagc caaataaata tatgctattt tcaaaaacaa aaatttgagc
    13261 aaaaacaata actattttta gacactgccc atttacatgc aaattaaaaa ttagcataaa
    13321 attctttaaa acttccccac gtttttctaa attcctgtag ggcgttttta tcaaaaatca
    13381 agacaagaag aaactcgttc acactcgttt caaaaaaaca agaaatctaa tctatacacc
    13441 taccgttttc caaccccctc aaagcataca aattaaaaac aaaattattc ataatcttac
    13501 tttcttttaa caaaaacata aaaaccataa atagacaaat taactatcaa aggcaataaa
    13561 cagtataaaa aaaccacgaa taaatcttca tcaacatcta aaataaaaaa gaataaaaca
    13621 attaacaaaa tactaattaa caaacctaaa agtggcaaac tttttatata tttttctaaa
    13681 ttttcattca taaaatagac tcctttcaaa aatatgttta taaatatatt aaaataaata
    13741 ttgattttat aaagcgctta cttatacaat taaaatatct tattatcttg gaggtatcaa
    13801 atgaaaatta taaaattatt ttcaataatt tccttgttcc tactggtatt tagcgcgaat
    13861 ttttctaatg cttacgcaaa tgaagaacaa aaaagttctt tactagaaaa tcaaaaagaa
    13921 aaattgaaaa gcaaaaacat cgaagtatca caaatgacca agaaagaaat aagttttcta
    13981 gaacaattgc aaaataaaaa tgaagatatg caaaaattcg aaaagcaaat gaaaaaagaa
    14041 ggatttaaaa aaataaagct agaagacaaa aattctaaat taaaatatct agctacagaa
    14101 gcaaatgata aaaatgcata tggctacata gctaataacg cttataaaaa tgaaaaaaca
    14161 aaagaaattg tagtttctga aacaatatat gataactaca acaaaaaaat cacaaaattc
    14221 attgccgaaa aaagaagtat gactgaaaac aaagagggaa aaatacttat taacaaaaat
    14281 tacgttgaat ataaggctga aaaagttgat aaaaacagac cggtaacata tgcaggattc
    14341 aaatggaacg gcaaagcatt cgcttgtagt atggctggac tttatgcatg tgctcactac
    14401 tgtggagtat gggcaatcgt aaatccaata gccggcggtg tatgtgaagc agtttgcgga
    14461 actgcatttg cagctggatg ctctgtaggt tgattttatt ccaattgttt tattgacgtt
    14521 gagcctcgga acccttaaca atcccaaaac ttgtcgaatg gtcggcttaa tagctcacgc
    14581 tatgccgaca ttcgtctgca agtttagtta agggttcttc tcaacatcaa taaatttttt
    14641 cggcataaat acgatgttcc ttatttatcc tcataaaaaa caatagctga aatatataac
    14701 caattactgt gtgtttgaat ttctaataca tgaatatcat tctttaaaaa cctattaact
    14761 tgtttatcta attgacgatg agtaaaagta gcgaaagttt taatcttcat gatatctctc
    14821 cttttataaa aatagcaatc cttattacaa tattaaacac ttttattttg gattttaaga
    14881 ggcattttga agacttagag gcaaatcata taggttttgt acttaaaaat ctatacagtc
    14941 tcttaaaacg caaatatgag ccaaataaat atatggtaat ttcacaaaca aaaatttcag
    15001 caaaaccagt gactaatttt ttaacactgc ccatttacat gcaaattaaa aattagcata
    15061 aaatccttta aaacttccac atgtttttct aaattcctgc agggcgtttt ttatcaaaaa
    15121 tcgagaattt ttaatttttc tctaaaaact ccgtaagagc ataaggagaa tttgctatca
    15181 ttcaaaaatg ataggtctgg caaagccaga aattccaggg gttttaaggt attttaaagt
    15241 gatatcatac aaagctgtac tgtcttattt ttgtgacaca atatattgcg tttgtcttat
    15301 ttttgtgaca ctacatacag catttgtcac aaaaataaga cagtactttt ttataaaaaa
    15361 tcaacaaaaa agacattagt caacactaat gtcttaaata ataattttgc ttttcgaaat
    15421 tccaaattgc ggtaattgaa tgtgcttttt cttcttcgtc tgttgtttta tcttcatcac
    15481 ttgtattaat caaattacca tcttcggcat cgtctaagtt taaaatttta tgcttttgtt
    15541 taagcaatcc accataactt aacatacgtt ttcgatacaa acctttttct aaatcactta
    15601 caatttcttg atttttttcg tcgtcatcag ttaaaaagtc agatgattta acggaatatt
    15661 ttgatgtctc ttcgagtgtt ataaaatcat ttgaattatt gattaaagat attatattgt
    15721 ttcatgtttt tacggcgcat ataaagggca tgtgtttctt caagttcagt tagaattgtt
    15781 tgcattaaat aagcttgcat tgacttgatt gtttcctttt ggcctttaac tcccctatca
    15841 tgtatagctt ttttaagtct ttttaaagaa gttaatattt catcctcaat gtcctctaac
    15901 atgtaatgca tatcttcatg ccttgaatta aatgattttt ttgctttaag aataacagcc
    15961 tttatgattt ctaaatctct ataatcatat tttaataaat aattagttag ttgttctggg
    16021 aattcttgca atagcatttc tttatcatca aaattatgtg taaattgatt tgaatgattt
    16081 gaatgattac taatttcatt tttgtacttt atatcattca agtcattcat atcattattc
    16141 tcagtatcat taaagtcaat gtcattaaag tcagtatcat tagtgttcga ttttcgaact
    16201 tctggacgtt cgattttcga acttctggac gttcgatttt cgaacttctg gacgttcgat
    16261 tttcgaactt ccttctcgcc gtaaggttca acatcgtttt cttctttttc tattttgtaa
    16321 atatcacgtt ctgtgacaat aggtttcatt aaatatagaa tatttggttt atttaaacca
    16381 cgtcgttttt gaatgagtag accatcgttt tctaaccctt tttttatttt tgttaacttt
    16441 tcttttttac aatttaagat ttccattagc ttttcatttg aataaacaaa gtaaatgtta
    16501 ccatcttcat caacccagct atttttaata gataaattta agcgatcacg taagatagca
    16561 taggctattt tcatatcatt agttagattt ttataatttt cactggtaaa gaatacttta
    16621 gggatttgat aaaatctttc tttgtaattt tcttgcactg taaaatattg attttgcatg
    16681 acaaaaaacc tctttccata ttttagtttg gtaagaggta ataaaacgtt tttatttagc
    16741 tttacattta tttaatgatt taggtgcttg cactaagata ttattcatta tataatacaa
    16801 gtatcgaaaa ttatataaat aaacagtttc taaacgtttt attaccaaac cccgactatt
    16861 accagtagtt ggggtttttg ttatattaag tttattatag cactttaaat aaacttataa
    16921 aagggaaaat atagctttat caagggttta taaacccttg ataaatatca taaacctttc
    16981 ataaaccctt gataaaaagg ttgatggatg tttattttta tttattaatc actttattat
    17041 taagcattat aagcttataa tattttatca agggtttata aacattttat aaagggttga
    17101 tgatatgaaa agtgtgaaaa agttgagtga agaattaggg gttagtaagc aaacgatttt
    17161 taataatatt aagcgattga atatagagac aataaaacag gaaaacactt cgtttattaa
    17221 agaagatacc gatatagaaa aaatcattca aagagtaaat gaaaataaaa agaaatatgg
    17281 ttttgaaagt actactgaag acaaacaaaa aaaagggtcg gataatatta attttgaatc
    17341 gaaaagcgat gctcaaatag tagaaatcct taaaaatcag attgatactt taaataatca
    17401 aattgaaaaa caagaaagtc gtcatgaaac aacaattgaa ttttacagaa aagagttgca
    17461 agaaagatca aaattgcttg aaaatcagca agttctggca ttagagagta ataaaaagat
    17521 tcaaaaatta gaaaatcaat tagaaaaaga aaaacacctt aattatccct ttgatacatc
    17581 tactaacact agacaaaacg ttgatgcaca agaaaaaaca tatactacta atcctgtaaa
    17641 tattaacaga gatcaggaag aaactaaaga aacagagatt caatataagg atatatctgg
    17701 aagtcaaagc gacgaaagta cacaaggtga agaagcaaaa aaagaagacg ttccagctaa
    17761 tctaaatgac aatgatagtg atatagaaga aaagagtgaa gaaacggaac ctaaaaaggg
    17821 gttttggagt cgtttgtttg gtagctaaaa taattgatta ggcactaaaa gttataaaat
    17881 tttagtgtct tttatatagt gagaacttct ggtaatcatc gattatgtaa actaaagtat
    17941 ttcaaataat taactgtatt aatactctca tcatgattgc gttataaacg ttcgttattg
    18001 agacaaaatt taatagtact actacacaaa aagagagtgc gaattcgcac tctctttttg
    18061 tgataaatga atggttaaga aaataattca tccacagttg tatcaaacaa tcttgccaac
    18121 ttaaatgcta atgtcaatgt aggatcatat ttattgtttt ctattgcatt aatagtttgc
    18181 ctagacactt ttaattcttt acttaaagtt tcttgagaaa ttcctttttg ttttctatat
    18241 tctctaattc tatttttcat taatttaacc tttagatgta tattttttat ttgtagtata
    18301 gtaattaaac agcataagaa atagtgctac aattataaag aaaatttctg gatattgaga
    18361 aaaccaagat ccttcaatac ttggtgacaa acctgtaaat ttaagcacta gtgtaaataa
    18421 catacaatat acaatccaaa taaaactttt agccagtatt tcaataaaca ttttacgttg
    18481 tctttcatcg tatcgatctt gttgtccttt tttatctaat gtttctgaag gtaaatattt
    18541 gttagttata gccgtccata aacaagaaaa aattaaaata ataataaaag gaattaaatt
    18601 cattataaca cctcataaat gtaaaaagta tttgacattt atgagtgtaa atatttttga
    18661 tacaaatgtc aaatactttt tacattataa tatattttaa aacaccttat tagtaaaaca
    18721 attactatat agaaagctgc gaactcgtac tcttttttct tgtataatta ttaaaatctc
    18781 aattcaataa tatgttatgg aatttgagac actgtgagag acgctcattt gcattgacaa
    18841 tcaatttatc aagataatcc cttatcatgt ttaattctat aaactgtttg tcttgtgata
    18901 ttaacttctt tcgcaatctt actaatcgct ttgccttctt ctaacatttc caccacgcga
    18961 tgataaataa cacgtttctg tgggtcttta gcatttggtg aataaagtaa agggcgccct
    19021 ttatatacgc ctttttcctt cgcaacttga atcccttgcg cttgtcgacg tttactttca
    19081 tttctctctt gttctgaaac cattgctaat atttgaatga ttaaatcttt cataaactta
    19141 tccagtaatg gattgccaat tacttcattc atcataggta agctggtaat cattaactga
    19201 acgtcttttt cttttaaata attcacagtt tcaataattt catcatagtt acgtcctaaa
    19261 cgatcaatag attccacaac gaatcgatct cccattctga caaaattgag tgcttcttga
    19321 aatacaggtc tattttccac tgactttccc gactgtttct ctgtaaagat tttctccaca
    19381 ccaaacgtct ttaaattatc caattgtctt tctaaatttt gatctatcga tgatactctc
    19441 gcataaccta taatcattca tcttcactcc ataataaata tacaccctaa tcatacgttt
    19501 taattgttat aatttcaaca attctttttg tatggttagg gtgtactcaa agtgtacata
    19561 tctataatta aaacttacta aaaataaata tagatttttt ctttgtaaca gaaccgttca
    19621 tttgaaggtc atctctatca taaatattta aattaactaa aaattttaat catctgttta
    19681 atacttatga aatgtattta cggtaggtat taaaattgat gaaatttata taagtgcttt
    19741 caatgaaaat gaccgtttat ttatcctcct gatttaagga gttagaaatt tcgaaaacga
    19801 ttctttccat ttgttgcatt tgttccatgt ccagatattt aatacattat agaaaaccaa
    19861 agaccatcac taattaaacg cagttttaaa atttcatcag gattgccttc gtctttaaaa
    19921 tgggcctctt ttaatataag ttctactctt tcatacctaa ctctttcaat gccatcgttt
    19981 catacgccga ttctcctgat tccatagcaa actcagcgat aaacattggg aatactgcat
    20041 tgagttctat tatatgctct ttcattcgtg gccatatttc acctccagct ttaccgtatg
    20101 ctgttataag ttgctctaat ccttcgtcgt cgaatacacg atggtgtcct ataaagtcca
    20161 ttgatgggtc ggagtgggtt gcttcagtcc agtctatgag acctgtgacg tttgcttggt
    20221 tatctaccat tatatgtcct ggatgtaagt ccccatgtat catggtcgca tgtcgaggcc
    20281 atagttcgtc gttttctaac cattgtttcc atctgttcca taattcatct gatacgccat
    20341 aagtttcttt aactttattc attcttcttt gaaagtcatt ttttatttct tgtatggttt
    20401 tgatatttat atgctgaacg ttaatgtttt cttctggtat gttgtgtaaa tctacgagtg
    20461 tttcagctaa tgtgttaata aagttttctg gtaatggttt gtgttcaatt tcccatacat
    20521 aattttgtat ttctggatct attgtggctg cgggtttacc tgtaagtttt gggtaagcaa
    20581 taaggtcttt tgcatgtact ttccacttcg gtatttcaaa tgaaacattc ttctgtaaga
    20641 agtctaccgt ttgtttttcg ggttttgttc gtttataaac gtcaggtctt cttggtagtc
    20701 tcaaaaccca ttctactcca tgtttatctt ttccaaatgc aacttgaaaa tcaagtcccg
    20761 attcattcaa tgagattgtt tgaggttgga tgtgtaattg atatttttct gcacatttaa
    20821 taatttcatt atgtcgagtc attttattgg atccttattt ctattatatt tttcttgtga
    20881 acgtattttt tatattgata taaatgaacc taatattcaa tataaattag tgtatagttt
    20941 ttaagttata tcatgaagag attgtcctgt taattcccat tttttatctg atacatgttt
    21001 aacaaacctt gtatcatgtg atgtaaacaa aatgattcca ggatatttat tcataaacat
    21061 ttctaatgct tctaatgttt taatatctaa aaaattagtt ggttcatcca aaattaacat
    21121 attcgctttc gttgaaaata atactgctaa cgataatttc gttctttccc caccactcaa
    21181 aacattacaa gaacgatcaa gtgcttcatt taaacccaag ttatttaaaa tagctctact
    21241 gaatgattct gatgaatccg tttcatccat taaatattgc aataatgaaa cgtcacgcat
    21301 gtcttcataa gcaagttgac gatagtatgc catttgcact ttaggagaac aatcaattcc
    21361 ctctatttgg tggtaaatag cttcaagtaa agttgtctta cctacaccat ttgcacctac
    21421 gagcgctata tttttgccat atggtatttg gaatcgtact tgtgttagca gtttttgact
    21481 tcctttaacc aatgttagat tttgtgcaat gattggataa ttattatgga tatcataaat
    21541 tttattttgt gggaaattga attcatgata actttgtggt ttttcaactt cttccaaatg
    21601 ttccattctt ttttcaatat gcttagcttg tttttgagca gccttctcaa ccgtgccttt
    21661 ttgttttgat gcacttaaac gatctggtgc tatacttttg tttttttgtt ttgatgatgc
    21721 ttgtgccatt tgttgcgctt gatttcgttt agctttactg gcttgggaca atctttgttt
    21781 ttcacttata tactgttcat attgacgttg ttgttctaac tgttcttgtt catattgatt
    21841 ttgatactgt gtgtaattac ctttaaacac tcttattgtg ccatcttctt gtatatccca
    21901 aattgtgtca gcaatttggt ctataagtgc tctatcatga cttactataa ttaaagtacc
    21961 atagtaatat tttaaaatat ttttcagata atctttacca attttatcca agtgatttgt
    22021 aggttcatct aaaagtaata tcggactata atttgatatg acattagcta atttatattt
    22081 tgctttttca ccaccactca tactgtcggt tgtatgcata ggtatatgga gttcactcat
    22141 taaactaccg tctaacgtgt taaaatcatt ttccacatcc atgttaagct gttcaaaata
    22201 ttgaatttcg ccaaccgttt caactgttcc agattctggt tttgtttttt gagcaatcat
    22261 atttagtaat gtggttttgc cagtaccatt acccccaata agtgctattt tttcaaattg
    22321 gtaagcgtaa agatgaccga tgttaagtga tcgtaaatct gtcaatttat gattgatttg
    22381 gttaaattta attgtatatt gttccatatt tatacactcc ttgtatattt aaaggacgtg
    22441 tacgcaaaaa aatgagacag gctactcccg tctcattcac attacacttt caaacactta
    22501 aaaatttatt atgatgtttt agtatttgaa agcgtttatt attcctatcg aaggataaaa
    22561 aatgacataa gtcatcctat gagtgtgtat tgcggacaag cctttttgaa ttaatttagt
    22621 tttgtattca aaaaggttta tttgagtctc atagaagctg tcattttaat cctccttcat
    22681 cgataaaata gtaatgttaa tataacattt tgttggtttt tttacaatat atctctaagt
    22741 agaaagatta tataacaaaa gtataaaaat acaattttag attgattata catctcctta
    22801 atttagagtg tactcataaa atacggttct gttgcaaagt tgaatttata atataatttt
    22861 aacaaaaagg agtcttctgt atgaactatt tcagatataa acaatttaac aaggatgtta
    22921 tcactgtagc cgttggctac tatctaagat atgcattgag ctatcgtgat atatctgaaa
    22981 tattaagaga acgtggtgta aacgttcatc attcaacgat ctaccgttgg gttcaagaat
    23041 atgccccaat tttatatcaa atttggaaga aaaagcataa aaaagcttat
//
