LOCUS       CP151586               23275 bp    DNA     circular BCT 21-APR-2024
DEFINITION  Staphylococcus aureus strain BSN201 plasmid pUSA04, complete
            sequence.
ACCESSION   CP151586
VERSION     CP151586.1
DBLINK      BioProject: PRJNA1048360
            BioSample: SAMN38637781
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 23275)
  AUTHORS   Berti,A.D., Gurdziel,K. and Liu,W.
  TITLE     Pre-publication release of Staphylococcus aureus str BSN201 whole
            genome sequence
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 23275)
  AUTHORS   Berti,A.D., Gurdziel,K. and Liu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-APR-2024) Pharmacy Practice, Wayne State University,
            259 Mack Ave, Detroit, MI 48201, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2024
            Assembly Method                   :: SPAdes v. FEB-2024
            Assembly Name                     :: BSN201
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: CP043386, CP014445
            Genome Coverage                   :: 115.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/15/2024 14:36:09
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,918
            CDSs (total)                      :: 2,836
            Genes (coding)                    :: 2,754
            CDSs (with protein)               :: 2,754
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 82
            CDSs (without protein)            :: 82
            Pseudo Genes (ambiguous residues) :: 0 of 82
            Pseudo Genes (frameshifted)       :: 41 of 82
            Pseudo Genes (incomplete)         :: 42 of 82
            Pseudo Genes (internal stop)      :: 17 of 82
            Pseudo Genes (multiple problems)  :: 17 of 82
            ##Genome-Annotation-Data-END##
            Bacteria and source DNA available from Andrew D. Berti, Wayne State
            University, Detroit MI  USA.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..23275
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="BSN201"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pUSA04"
                     /geo_loc_name="USA: Detroit, MI"
                     /lat_lon="42.33 N 83.05 W"
                     /collection_date="2018-03-12"
                     /collected_by="Andrew D. Berti"
     gene            complement(60..734)
                     /locus_tag="UXQ46_14455"
     CDS             complement(60..734)
                     /locus_tag="UXQ46_14455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004803 - transposase activity [Evidence IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WZO22604.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            996..1181
                     /locus_tag="UXQ46_14460"
     CDS             996..1181
                     /locus_tag="UXQ46_14460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WZO22605.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            complement(1404..1982)
                     /locus_tag="UXQ46_14465"
     CDS             complement(1404..1982)
                     /locus_tag="UXQ46_14465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WZO22606.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(2247..2627)
                     /gene="blaI"
                     /locus_tag="UXQ46_14470"
     ARG             complement(2251..2627)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.41"
                     /coverage="100.0"
     gene            complement(2617..4374)
                     /gene="blaR1"
                     /locus_tag="UXQ46_14475"
     ARG             complement(2621..4374)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.38"
                     /coverage="100.0"
     gene            4481..5326
                     /gene="blaZ"
                     /locus_tag="UXQ46_14480"
     ARG             4482..5323
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(5852..6271)
                     /locus_tag="UXQ46_14485"
     CDS             complement(5852..6271)
                     /locus_tag="UXQ46_14485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="WZO22610.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            6395..7366
                     /locus_tag="UXQ46_14490"
     CDS             6395..7366
                     /locus_tag="UXQ46_14490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="WZO22611.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(7538..7630)
                     /locus_tag="UXQ46_14495"
     CDS             complement(7538..7630)
                     /locus_tag="UXQ46_14495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WZO22612.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(7787..8134)
                     /locus_tag="UXQ46_14500"
     CDS             complement(7787..8134)
                     /locus_tag="UXQ46_14500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]; GO_process: GO:0006355 - regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WZO22613.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(8153..8770)
                     /gene="cadD"
                     /locus_tag="UXQ46_14505"
     ARG             complement(8157..8770)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(9886..10080)
                     /locus_tag="UXQ46_14510"
     CDS             complement(9886..10080)
                     /locus_tag="UXQ46_14510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WZO22615.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            10190..10882
                     /locus_tag="UXQ46_14515"
     CDS             10190..10882
                     /locus_tag="UXQ46_14515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative immunity/bacteriocin fusion bifunctional
                     protein"
                     /protein_id="WZO22616.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="putative immunity/bacteriocin fusion bifunctional
                     protein"
     gene            complement(11050..11199)
                     /locus_tag="UXQ46_14520"
     CDS             complement(11050..11199)
                     /locus_tag="UXQ46_14520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WZO22617.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(11746..12035)
                     /locus_tag="UXQ46_14525"
                     /pseudo=""
     CDS             complement(11746..12035)
                     /locus_tag="UXQ46_14525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009384749.1"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology. GO_function: GO:0003677 - DNA binding
                     [Evidence IEA]; GO_process: GO:0006260 - DNA replication
                     [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(12055..13038)
                     /locus_tag="UXQ46_14530"
     CDS             complement(12055..13038)
                     /locus_tag="UXQ46_14530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WZO22595.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFENRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            13464..14207
                     /locus_tag="UXQ46_14535"
     CDS             13464..14207
                     /locus_tag="UXQ46_14535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WZO22596.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(14434..14619)
                     /locus_tag="UXQ46_14540"
     CDS             complement(14434..14619)
                     /locus_tag="UXQ46_14540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WZO22597.1"
                     /translation="MKNRIREYRKQKGISQETLSKELKVSRQTINAIENNKYDPTLTLA
                     FKLARLFDTTVDELFS"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(14624..14962)
                     /locus_tag="UXQ46_14545"
     CDS             complement(14624..14962)
                     /locus_tag="UXQ46_14545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WZO22598.1"
                     /translation="MNLIPFIIILIFSCLWTAITNKYLPSETLDKKGQQDRYDERQRKM
                     FIEILAKSFIWIVYCMLFTLVLKFTGLSPSIEGSWFSQYPEIFFIIVALFLMLFNYYTT
                     NKKYTSKG"
                     /name="hypothetical protein"
     gene            complement(15208..15816)
                     /locus_tag="UXQ46_14550"
     CDS             complement(15208..15816)
                     /locus_tag="UXQ46_14550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WZO22599.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTFGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKDVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGKAISKIAKEVNITRQTVYRIKHDKGLS"
                     /name="recombinase family protein"
     gene            complement(16302..17201)
                     /locus_tag="UXQ46_14555"
     CDS             complement(16302..17201)
                     /locus_tag="UXQ46_14555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000196697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mph(C) family macrolide 2'-phosphotransferase"
                     /protein_id="WZO22600.1"
                     /translation="MTRHNEIIKCAEKYQLHIQPQTISLNESGLDFQVAFGKDKHGVEW
                     VLRLPRRPDVYKRTKPEKQTVDFLQKNVSFEIPKWKVHAKDLIAYPKLTGKPAATIDPE
                     IQNYVWEIEHKPLPENFINTLAETLVDLHNIPEENINVQHINIKTIQEIKNDFQRRMNK
                     VKETYGVSDELWNRWKQWLENDELWPRHATMIHGDLHPGHIMVDNQANVTGLIDWTEAT
                     HSDPSMDFIGHHRVFDDEGLEQLITAYGKAGGEIWPRMKEHIIELNAVFPMFIAEFAME
                     SGESAYETMALKELGMKE"
                     /name="Mph(C) family macrolide 2'-phosphotransferase"
     gene            complement(17300..18766)
                     /gene="msr(A)"
                     /locus_tag="UXQ46_14560"
     ARG             complement(17304..18766)
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            19240..19914
                     /locus_tag="UXQ46_14565"
     CDS             19240..19914
                     /locus_tag="UXQ46_14565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004803 - transposase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WZO22602.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            19972..20349
                     /locus_tag="UXQ46_14570"
                     /pseudo=""
     CDS             19972..20349
                     /locus_tag="UXQ46_14570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019834602.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]; GO_process: GO:0006355 - regulation
                     of DNA-templated transcription [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /name="response regulator transcription factor"
     gene            20346..21227
                     /locus_tag="UXQ46_14575"
                     /pseudo=""
     CDS             20346..21227
                     /locus_tag="UXQ46_14575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015581923.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]; GO_function: GO:0004673 - protein
                     histidine kinase activity [Evidence IEA]; GO_function:
                     GO:0005524 - ATP binding [Evidence IEA]; GO_process:
                     GO:0007165 - signal transduction [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /name="sensor histidine kinase"
     gene            21343..22272
                     /locus_tag="UXQ46_14580"
     CDS             21343..22272
                     /locus_tag="UXQ46_14580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0005524 - ATP binding [Evidence IEA]; GO_function:
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]; GO_function:
                     GO:0140359 - ABC-type transporter activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WZO22618.1"
                     /translation="MKNLNNIIEINNLTKQYGSQIAVNNLSITVESGQIYGFLGRNGAG
                     KTTTIRMLLGLIKPTKGNIKIFEKEFESNKTEILKNIGAMVETPGFYSNLTAKENLTIN
                     AKILGIQKENAIEEVLEIVGLASEKVKLFKNYSLGMKQRLGIARALLHNPELLILDEPT
                     NGLDPIGIKEIRKLIKDLAQSRNITILISSHILSEIEQLVDKVGIIHNGVLLEEIMYED
                     LKKKNRQFISISVSDEEKVACLLETNFGIYDYKIKENGEFKIYSHIDRQQEINRLLVLN
                     NIDVFQMRVIEDNLETYFEDLVGGGTIG"
                     /name="ABC transporter ATP-binding protein"
     gene            22265..23002
                     /locus_tag="UXQ46_14585"
     CDS             22265..23002
                     /locus_tag="UXQ46_14585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000369394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0042626 - ATPase-coupled transmembrane transporter
                     activity [Evidence IEA]; GO_function: GO:0140359 - ABC-type
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="WZO22603.1"
                     /translation="MDNLLRTEFIKLKRSYMFLISILGTCVAPFMVVVASFISMRTKVP
                     TPNIVFKQLFEEVSLYHMLIIGPPLYGVIIAYLFGREYIEDTLKNLLIIPISRESFLVS
                     KIILLFLWIQTLSVIAWLLTLMLGMLLHFQGLSQSLIIDSFFTFVIGGVLLWILSPPII
                     ILSIYFKNYVPTIVLTIIITLINLMTANSEHRGLFPWAAVGDISRGTLPNTYPFLLSLI
                     IIIVTSIFSVIILFSYFKKTDIS"
                     /name="ABC transporter permease"
     gene            23016..23192
                     /locus_tag="UXQ46_14590"
                     /pseudo=""
     CDS             23016..23192
                     /locus_tag="UXQ46_14590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_499250.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0050380 - undecaprenyl-diphosphatase
                     activity [Evidence IEA]; GO_process: GO:0016311 -
                     dephosphorylation [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /name="undecaprenyl-diphosphate phosphatase"
     ARG             complement(16306..17201)
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(17301..18766)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             complement(16303..17201)
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             4482..5326
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     Typing          complement(11543..11690)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          complement(11749..11924)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="92.697"
                     /coverage="94.0"
                     /evalue="1.04e-65"
     Typing          complement(12056..13038)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.593"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          13465..14207
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 ggttctgttg caaagtaaaa aaatatagct aaccactaat ttatcatgtc agtgttcgct
       61 taacttgcta gcatgatgct aatttcgtgg catggcgaaa atccgtagat ctgaagagac
      121 ctgcggttct ttttatatag agcgtaaata cactcaatac cttttaaagt attctttgct
      181 gtattgatac tttgatacct tgtctttctt actttaatat gacggtgatc ttgctcaatg
      241 aggttattca gatatttcga tgtacaatgg cagtcaggtt taagtttaaa agctttaatt
      301 actttaacca ttgctacctt cgttgaaggt gcctgatctg taattacctt ttgaggttta
      361 ccaaattgtt taatgagacg tttgataaac gcatatgctg aatgattatc tcgttgctta
      421 cgcaaccaaa tatctaatgt atgtccctct gcatcaatgg cacgatataa atagctccat
      481 tttcctttta ttttgatgta cgtctcatca atacgccatt tgtaataagc ttttttatgc
      541 tttttcttcc aaatttgata taaaattggg gcatattctt gaacccaacg gtagaccgtt
      601 gaatgatgaa cgtttacacc acgttccctt aatatttcag atatatcacg ataactcaat
      661 gcatatctta gatagtagcc aacagctaca gtgataacat ccttgttaaa ttgtttatat
      721 ctgaaatagt tcatacagaa gactcctttt tgttaaaatt atactataaa ttcaactttg
      781 caacagaacc tcatttacta tatgggcatc tctttcatta ttaatacaaa gctttgtatc
      841 tccgatatta ggcaaaggtg taaacgaatt aggtgatact ataggattca acattatatt
      901 aatcgtttct ttaataatga ttatcttctt attttttata aatcgtagta aaaatatctc
      961 ctatgattat ataaaagttc aaagaggtga agccaatgaa taaattagaa aaatggtctt
     1021 tggtatttat tatttttaca tttctctctt cattagcact tttatatttc aaatataatt
     1081 ttagttcggt tatgccagtc ctaagtcttt ctattttaac tatactaata ttgttgacga
     1141 gtattattac tgtagtttca gttaatgatg aagatactta aaacgttcat tagtgaaaca
     1201 ggtattatat taaaaaagcg tacgaatttg tacgcttttt tcttgtgtta ttattaaaat
     1261 ctcataacag gaaaatatta tgagatttta gacgctgtca gaacgtctct tttacatcga
     1321 gtgacattga atcaaagtct ttgtatgtta atgatatata aaattattta gtagattcat
     1381 tatagtaagc tagattagtt gctctacttg tttttattct cttttgcctc taatttattg
     1441 agataacgat aaatagttgt acgtgaaact tgccactgct ctgcaattgt tttaattggc
     1501 gtaccattat cataaagtgt cttaagtaag tttaaatctt gtttatttaa tttttcaggt
     1561 ctacctccat atcggcctct agcacgtgct gcaattcgac cggctgatga tcgctctaaa
     1621 attaaattac gttcaaactc tgcaaatgct gcgaataaat gaaataataa ttgtcctgta
     1681 gaacttgatt tatccatcgt tatattttct tctaaactat gaaaactcac acctcgttcg
     1741 ttaagttcat taactaacgt gattaaatcc tccatgttcc gtcctagtct atctaatctc
     1801 caaacaacaa tcgtatctcc tgacctcgca aattcaattg ctttatctaa accaggtcgc
     1861 ttactttttg aaccactcat atggtcatta aatatctttt cacaaccata tgtatttaat
     1921 cgatcctcct gtaaattcaa attttgtaat ccagttgaaa ctcttgcata acctattttc
     1981 aaaatacaga cctcctatat acacctttag tgtaccataa cttgattacg aggtcttttg
     2041 tgaacataga ttttttgttg ggtttttgaa cacataattc tatgtaatac ttacttattt
     2101 agacaaaaaa caagagtgta cagaaaatgg gttattttct ggacactctc atctttaata
     2161 atatatttta aatgtcatta acaaaactaa tttaataaga gtcaagtatg gtttacatat
     2221 gtattatgtt tgaaacatac ctctaattac tttttactaa tatcatttaa aatgtctcgc
     2281 aattcttcaa tttctttgtt atttaattct tcatttttcg caaaattcag cactaaactt
     2341 ttcatatccc ctccatacag tttattaaga aaggttttag cagttttcat tttaatatcg
     2401 tcttctttaa tatttgatga gtaaaaataa atattttctg atttgtatcg ttttataatc
     2461 tcttttttat atagtcttgt gattaatgtt ctaatcgttt tatcactaac ttctttatat
     2521 ttttgaattt caactacaat ttcattagct gatactgatt ttttatccca tattatattc
     2581 ataacatccc attcagccat agatatttca acttgcttat tggtcattta aaacacccat
     2641 tccttttaat attttttcac ttattaattc agcatttttc ccagacgggt ttccatctga
     2701 taaatgtgta gcaaaataat acttatcatg atttgtaatt acgtaaccta caaaccaccc
     2761 attattatac ttcccgttta ctatacctgt acctgttttc ccatacagtt catacttttc
     2821 atttttctta atcaataatg aagaagataa ttgattcttt gcttttttac taaaatggtt
     2881 attttgttcc atcatatttt taaaaactat tacttgttca agattagata ttttcaaact
     2941 atcttccatc caatagcttt tataacttcc caaattttca ttaccataat ttaattgctt
     3001 gagttgagcc gcagtatagt tctttggtat ttgattacta atacgttcga agtaccaatt
     3061 aactgaattt tgcattgctg tatttaaatc ttgttcctta ttccaagact cgaaaagata
     3121 atgtttatga ttccatgaca tacgtgaatt tttatcactt ataatatgac ggtcaagtcc
     3181 aaacagtgct aaataaattt tgtaagttga atcaggagaa tatctttttc tactttcttt
     3241 ttcattataa atatagtatt tgtctttctt catgctgtac ataacgaaag atccactatt
     3301 tgaaccaaaa tttttacttt catctaaaat ttggtaatcg ctttgtaagg gctttttata
     3361 attataatca gttaaggatt gccccattaa aaactggctt tgaattatca tgataaaaaa
     3421 agtaaaaata caaataaaaa ttagaattaa ttttgactgc tttttcagat cggcttcttt
     3481 tatattaatt aatctacttt tgagtaatga ttttttacca ttaaatgaat ggcttaatat
     3541 atttttgttg gaaaatgggg tttttaatac ggagtccata atagattccg cataagtttt
     3601 aaattcattt ttgttaatat tattaaggac aaatctatcg gcttctactt cattgtcatg
     3661 aattatcttt ctttttacaa tatgtactaa tggattgtaa ctcataataa tagagaagat
     3721 attaaagata attaaatgta aagtatctct atttttagca tgagcatatt catgcagtat
     3781 tatatatttt agtcttttat caattacact tttaaaatat gaactaggaa tcaaaataat
     3841 atatttccca taccaaaaag ttattggaga ttgaatagcc tctgcttttc gaatcacaat
     3901 atttttttta tattgatggt tgaaaagtat cgtatctatt ttattttttt cattttcgtt
     3961 tagataaagt gactgtttct ttaaatattt aagatataat aaggctttca aaaatttaaa
     4021 acttaaaata ataactaaaa ctatccaaat aactgtgcag atattatcaa ttgaatccca
     4081 attaaactta tggatatctg ttgtgaactc ttgaataggt ttggtggtat ttatgttatg
     4141 gttcaaatcg tgtgacttac tttcaactgt gggcgcttga ttattcacat tattaaattt
     4201 tataaaagag aatttaattg ggataaaagg aattaatcca gcaagcatag ttagatacca
     4261 aactttataa tttaaactat aattaaaata gcgttttaat atgtacctaa aaaatactaa
     4321 caatagaaat ataaaacaaa agcttactac gctcattatt agtaatttag ccattttgac
     4381 accttctttc aaatatttat aataaacaat tgacatcaat attacaattg taatattatt
     4441 gatttataaa aattacaact gtaatatcgg agggtttatt ttgaaaaagt taatattttt
     4501 aattgtaatt gctttagttt taagtgcatg taattcaaac agttcacatg ccaaagagtt
     4561 aaatgattta gaaaaaaaat ataatgctca tattggtgtt tatgctttaa atactaaaag
     4621 tggtaaggaa gtaaaattta attcagataa gagatttgcc tatgcttcga cttcaaaagc
     4681 gataaatagt gctattttgt tagaacaagt accttataat aagttaaata aaaaagtaca
     4741 tattaacaaa gatgatatag ttgcttattc tcctatttta gaaaaatatg taggaaaaga
     4801 tatcacttta aaagaactta ttgaggcttc aatgacatat agtgataata cagcaaacaa
     4861 taaaattata aaagaaatcg gtggaatcaa aaaagttaaa caacgtctaa aagaactagg
     4921 agataaagta acaaatccag ttagatatga gatagaatta aattactatt caccaaagag
     4981 caaaaaagat acttcaacgc ctgctgcttt cggcaagact ttaaataaac ttatcgcaaa
     5041 tggaaaatta agcaaaaaaa ataaaaattt cttacttgat ttaatgttta ataataaaaa
     5101 cggagacact ttaattaaag atggtgttcc aaaagactat aaggttgctg ataaaagtgg
     5161 tcaagcaata acatatgctt ctagaaatga tgttgctttt gtttatccta agggccaatc
     5221 tgaacctatt gttttagtca tttttacgaa taaagacaat aaaagtgata agccaaatga
     5281 taagttgata agtgaaaccg ccaagagtgt aatgaaggaa ttttaatatt ctaaatgcat
     5341 aataaatact gataacatct tatagtttgt attatatttt gtattatcgt tgacatgtat
     5401 aattttgata tcaaaaactg attttccctt tattattttc gagatttatt ttcttaattc
     5461 tctttaacaa actagaaata ttgtatatac aaaaaatcat aaataataga tgaatagttt
     5521 aattataggt gttcatcaat cgaaaaagca acgtatctta tttaaagtgc gttgcttttt
     5581 tctcatttat aaggttaaat aattctcata tatcaagcaa agtgacaata gcattttaca
     5641 agtatttttt attgttcgat tagggtaaac ctaaataata cataaattat attacaatat
     5701 gtttattata gaggctaaag tatcttagaa atttggatag taggtttttc gggaataaaa
     5761 gtatagttgg ctttaatata taattaagct aagctatcat ttatatttac tcgattataa
     5821 ttcgcacttc aactttttta taacgtaaaa attaaaacgt agttttattt atctttagta
     5881 atatcttttt aaacactaca gtttcttcat tagttaaatt agcgaagtaa tgattattaa
     5941 gttgataggc tttcttttct aatgttggcc ataagtcttt tgctttattt gtactgttta
     6001 ttagcacagt tcttctattt tcattatcag tttgacgtgt tattagatcc tttttggaca
     6061 tcttatctaa tattccagat attgttgaag gttctaaatt taaagtatta ccaatcgctt
     6121 taggtgtatt caaattacta ttaatcaagc aattcaaaac accatattct gctggagtaa
     6181 tattataggg acttaataaa cttttaaaat gtttaaaaac tctattctga gaagtactca
     6241 acaaataatt tatacaatta tctaattcca caactaaaac ctctcttaaa tcattagtat
     6301 tgactcgctt atcatatcat gataagtttt gtaggaaaat agttttgcaa caaaaacata
     6361 cttctacaaa acaattgtga aagaaggcta ataaatgttc aatgcggtag tagtgagaaa
     6421 aagtgcatca aatgttagtt ataaagtaga aaaagttgat gaatctcatt tatcgaaggg
     6481 tgatgtatta gtaaaagtgg tatactcttc aataaattat aaggatatgc tagctttaca
     6541 atataaaggc ggtgtaatta gagattatcc tatgattcct ggtatagatt ttgcaggtat
     6601 tgttgaatca agttcgaatg ataagtttaa agaaggcgat aatgtattag ttactggtta
     6661 tgatgttggc gtgacacata caggtggatt ttcagaatat gcacaagtgc ctggagagtg
     6721 gattgttcct attccccaag aaatgtctat taaagagtct atggtatatg gcacagccgg
     6781 ttttacggca gcattatcaa tttttgaact agaaaaatat ggaatgaata tcaaatcaca
     6841 acctgaaatt ttagtgtctg gggctacagg tggtgtgggc agtgttgcta tacaaatttt
     6901 acataaaatt ggatatgaaa atatcactgc tatcgtaaga aaagaaaagc aaatagaaat
     6961 cgcaaaaaaa ttaggtgcaa aacaagtaat aataattgaa gatgataata aaccgcttaa
     7021 aaaaggtatt tttgattatt tcttagatac agtggggagt aatgtaacat tatacggttt
     7081 aaaacgtcta aattatcaag gtgttgctac tgtatgtgga aatgtagcag gaaattcact
     7141 taacgctaat atattaccgt ttattcttag aggtattaaa ttaattggca ttgattctgt
     7201 atatgttgat cataatatcc gtgaagatat atggagtaag ttagcaaatg aatggaatat
     7261 aggaaattca cttctataca atgaaattgg atttgaagaa ttctataaaa cgatagatca
     7321 gcttttaaaa ggacaacatt taggaagaac tattttaaaa gtataagtgt gagtattcat
     7381 taatacattt actattaatt caatcatttt gcatttctct actaaccagt gttataattt
     7441 atataacgaa aatgattaac aattaatgca ccaatcccca cactattgca gtagtgtggg
     7501 gattttttcg atgctggctt ataaagtcgc ctattaatta tttgttgcgt ttactaagcc
     7561 aataagtata atacgcaaca gcacagccac tgatgactgg tgctatgatg tgaacgaaaa
     7621 tgattagcaa agtaatgcac ctcctctctt cgtcaattga cgcctgagag ataggcgact
     7681 ctattattat accatctgtg aatatacaag catatctact tccgataagt cgtcttatgt
     7741 tatataactt tgttttttat agtatcaaga caagaagaaa ctcgtttcaa aaaccctcat
     7801 gatttttaga gaaaaactct cttatttcat cgtctttaat aaaataatat gccatctttc
     7861 catctttata aaaatcaagt acctcatttt tatataaaag ccttaaatga tgtgaagttg
     7921 aagcaacact cattttcaat atcaaagaaa tatcacaaac acacaactca tcttctttaa
     7981 tcaaagataa tatgattttc aatttcttct catcacaaat tttttctaaa atgttaagta
     8041 atttcttaga tttatcatct tctaaaaaac ttaaagcatt gttaacttta tcctcatgta
     8101 cacagatcac atcacaagta ttttcataac tcatataaaa tcacacccta aattaaaata
     8161 taaatcctaa aattgtttga atagtgtcat tttcaataat aataaataaa cctaaagcta
     8221 tataaataat agccataatc caacgactaa atttctcaac aatttctcca attcctggaa
     8281 tattagctaa tttttgtgca gtaaacacca agaagaaaat taaaattaaa aagacaaaca
     8341 gagtaagtaa taaattagta acacttaatg tcacaaaata cggaacaaat aaaccaatat
     8401 tatcggcgcc acaacttgct atcgtaacaa ttgcaaccgt accaactaat ttagacaatc
     8461 ctttttcatt caattctttt ttagctctct tttctccttc acaatcatca taaatagcca
     8521 ctttaattcc aagataaatt ggtattaaac ccaataaacc taatatccac ttttctggaa
     8581 cataatttaa tacaaaagct aaaaacaaac taactaatat taaaataata gaccctaaat
     8641 attgaccaac ataaatatct ctatattctt ttctagtctt tgctctagca aaaaatatta
     8701 ataaaattac taataaatca actgctgtag caatataaag aacagcagca gcaacaaccg
     8761 tttgaatcat aatacacctc attcaaaaat atttttgaat gtattataac ttatattttt
     8821 aaataatcat aggtgcttta ttccaattgc tttattgacg ttgagcctcg gaacccttaa
     8881 caatcccaaa acttgtcgaa tggtcggctt aatagctcac gctatgccga cattcgtctg
     8941 caagtttagt taagggttct tctcaacatc aataaatttt ttcggcataa atgcgtgtct
     9001 atgcgtagac atggagacac ttcagaatta tggagtgatt acatgagttt aactattttt
     9061 ctttattcag ttttaggaag tttattagca aattatatct acgaaaaatc ttcaaaataa
     9121 ataacttttt cggttctact ttgtacactt tatctacctg gtagacctaa ttgttattgc
     9181 tttacaggtc taaaattcgt cgttataatc tagttaaatc ccgtaagggc gcacttatac
     9241 gtcggataaa tcgacatgtg caaaaacgta atcgaccttc gtcgattttt ttatttcaaa
     9301 attaaagaaa cggcttgaga tattccgagc agttataaaa attaatttgc gttgaatatt
     9361 gctactacat tcttgaaaaa gtgatgtaga tttatagccc ataacttttt tgaattacat
     9421 cgacgatacg gcgtcgaaag aaaaataaat agaccgtatg aaagaaaaag ctacctcact
     9481 ttatctgggg tagcttttat tttttatgcc cttattttga attttaagag ggcattttaa
     9541 agatttaggg gtgattcata tagttttata tctaaaactt atatatgctt ttaaaacgca
     9601 aatatgagcc aaataaatat atgctatttt caaaaacaaa aatttgagca aaaacaataa
     9661 ctatttttag acactgccca tttacatgca aattaaaaat tagcataaaa ttctttaaaa
     9721 cttccccacg tttttctaaa ttcctgtagg gcgtttttat caaaaatcaa gacaagaaga
     9781 aactcgttca cactcgtttc aaaaaaacaa gaaatctaat ctatacacct accgttttcc
     9841 aaccccctca aagcatacaa attaaaaaca aaattattca taatcttact ttcttttaac
     9901 aaaaacataa aaaccataaa tagacaaatt aactatcaaa ggcaataaac agtataaaaa
     9961 aaccacgaat aaatcttcat caacatctaa aataaaaaag aataaaacaa ttaacaaaat
    10021 actaattaac aaacctaaaa gtggcaaact ttttatatat ttttctaaat tttcattcat
    10081 aaaatagact cctttcaaaa atatgtttat aaatatatta aaataaatat tgattttata
    10141 aagcgcttac ttatacaatt aaaatatctt attatcttgg aggtatcaaa tgaaaattat
    10201 aaaattattt tcaataattt ccttgttcct actggtattt agcgcgaatt tttctaatgc
    10261 ttacgcaaat gaagaacaaa aaagttcttt actagaaaat caaaaagaaa aattgaaaag
    10321 caaaaacatc gaagtatcac aaatgaccaa gaaagaaata agttttctag aacaattgca
    10381 aaataaaaat gaagatatgc aaaaattcga aaagcaaatg aaaaaagaag gatttaaaaa
    10441 aataaagcta gaagacaaaa attctaaatt aaaatatcta gctacagaag caaatgataa
    10501 aaatgcatat ggctacatag ctaataacgc ttataaaaat gaaaaaacaa aagaaattgt
    10561 agtttctgaa acaatatatg ataactacaa caaaaaaatc acaaaattca ttgccgaaaa
    10621 aagaagtatg actgaaaaca aagagggaaa aatacttatt aacaaaaatt acgttgaata
    10681 taaggctgaa aaagttgata aaaacagacc ggtaacatat gcaggattca aatggaacgg
    10741 caaagcattc gcttgtagta tggctggact ttatgcatgt gctcactact gtggagtatg
    10801 ggcaatcgta aatccaatag ccggcggtgt atgtgaagca gtttgcggaa ctgcatttgc
    10861 agctggatgc tctgtaggtt gattttattc caattgtttt attgacgttg agcctcggaa
    10921 cccttaacaa tcccaaaact tgtcgaatgg tcggcttaat agctcacgct atgccgacat
    10981 tcgtctgcaa gtttagttaa gggttcttct caacatcaat aaattttttc ggcataaata
    11041 cgatgttcct tatttatcct cataaaaaac aatagctgaa atatataacc aattactgtg
    11101 tgtttgaatt tctaatacat gaatatcatt ctttaaaaac ctattaactt gtttatctaa
    11161 ttgacgatga gtaaaagtag cgaaagtttt aatcttcatg atatctctcc ttttataaaa
    11221 atagcaatcc ttattacaat attaaacact tttattttgg attttaagag gcattttgaa
    11281 gacttagagg caaatcatat aggttttgta cttaaaaatc tatacagtct cttaaaacgc
    11341 aaatatgagc caaataaata tatgctaatt tcacaaacaa aaatttcagc aaaatcagtg
    11401 actaattttt tagatactgc ccatttacat gcaaatttaa aaattagcat aaaatacttt
    11461 aaaacttccc catgtttttc taaattcctg cagggctttt cttatcaaaa acttagaaat
    11521 tttaatttaa ctctaaaatc tccgtaagag cataagggaa atttgctatc attcaaaaat
    11581 gatagatctg gcaaggccag acattccaag ggttttaagt tattttaaag tgatatcata
    11641 caaagctgta gtgtcacact tttgtgacac tacatacagc atttgtcaca aaaataagac
    11701 agcacttttt tacagaaaaa caataaaaaa agacatcagt tatcactaat gtcttaaata
    11761 ataattttgc ttttcgaaat tccaaattgc ggtaattgaa tgtgcttttt ttcttcgtct
    11821 gtcgttttat cttcatcact tgtattaatc aaattaccat cttcggcatc gtctaagttt
    11881 aaaattttat gcttttgttt aagcaatcca ccataactta acatacgttt tcgatacaaa
    11941 cctttttcta aatcacttac aatttcttga tttttttcgt cgtcatcagt taaaaagtca
    12001 gatgatttaa cggaatattt tgatgtctct tcgagtgtta taaaatcatt tgaattattg
    12061 attaaagata ttatattgtt tcatgttttt acggcgcata taaagggcat gtgtttcttc
    12121 aagttcagtt agaattgttt gcattaaata agcttgcatt gacttgattg tttccttttg
    12181 gcctttaact cccctatcat gtatagcttt tttaagtctt tttaaagaag ttaatatttc
    12241 atcctcaatg tcctctaaca tgtaatgcat atcttcatgc cttgaattaa atgatttttt
    12301 tgctttaaga ataacagcct ttatgatttc taaatctcta taatcatatt ttaataaata
    12361 attagttagt tgttctggga attcttgcaa tagcatttct ttatcatcaa aattatgtgt
    12421 aaattgattt gaatgatttg aatgattact aatttcattt ttgtacttta tatcattcaa
    12481 gtcattcata tcattattct cagtatcatt aaagtcaatg tcattaaagt cagtatcatt
    12541 agtgttcgat tttcgaactt ctggacgttc gattttcgaa cttctggacg ttcgattttc
    12601 gaacttctgg acgttcgatt ttcgaacttc cttctcgccg taaggttcaa catcgttttc
    12661 ttctttttct attttgtaaa tatcacgttc tgtgacaata ggtttcatta aatatagaat
    12721 atttggttta tttaaaccac gtcgtttttg aatgagtaga ccatcgtttt ctaacccttt
    12781 ttttattttt gttaactttt cttttttaca atttaagatt tccattagct tttcatttga
    12841 ataaacaaag taaatgttac catcttcatc aacccagcta tttttaatag ataaatttaa
    12901 gcgatcacgt aagatagcat aggctatttt catatcatta gttagatttt tataattttc
    12961 actggtaaag aatactttag ggatttgata aaatctttct ttgtaatttt cttgcactgt
    13021 aaaatattga ttttgcatga caaaaaacct ctttccatat tttagtttgg taagaggtaa
    13081 taaaacgttt ttatttagct ttacatttat ttaatgattt aggtgcttgc actaagatat
    13141 tattcattat ataatacaag tatcgaaaat tatataaata aacagtttct aaacgtttta
    13201 ttaccaaacc ccgactatta ccagtagttg gggtttttgt tatattaagt ttattatagc
    13261 actttaaata aacttataaa agggaaaata tagctttatc aagggtttat aaacccttga
    13321 taaatatcat aaacctttca taaacccttg ataaaaaggt tgatggatgt ttatttttat
    13381 ttattaatca ctttattatt aagcattata agcttataat attttatcaa gggtttataa
    13441 acattttata aagggttgat gatatgaaaa gtgtgaaaaa gttgagtgaa gaattagggg
    13501 ttagtaagca aacgattttt aataatatta agcgattgaa tatagagaca ataaaacagg
    13561 aaaacacttc gtttattaaa gaagataccg atatagaaaa aatcattcaa agagtaaatg
    13621 aaaataaaaa gaaatatggt tttgaaagta ctactgaaga caaacaaaaa aaagggtcgg
    13681 ataatattaa ttttgaatcg aaaagcgatg ctcaaatagt agaaatcctt aaaaatcaga
    13741 ttgatacttt aaataatcaa attgaaaaac aagaaagtcg tcatgaaaca acaattgaat
    13801 tttacagaaa agagttgcaa gaaagatcaa aattgcttga aaatcagcaa gttctggcat
    13861 tagagagtaa taaaaagatt caaaaattag aaaatcaatt agaaaaagaa aaacacctta
    13921 attatccctt tgatacatct actaacacta gacaaaacgt tgatgcacaa gaaaaaacat
    13981 atactactaa tcctgtaaat attaacagag atcaggaaga aactaaagaa acagagattc
    14041 aatataagga tatatctgga agtcaaagcg acgaaagtac acaaggtgaa gaagcaaaaa
    14101 aagaagacgt tccagctaat ctaaatgaca atgatagtga tatagaagaa aagagtgaag
    14161 aaacggaacc taaaaagggg ttttggagtc gtttgtttgg tagctaaaat aattgattag
    14221 gcactaaaag ttataaaatt ttagtgtctt ttatatagtg agaacttctg gtaatcatcg
    14281 attatgtaaa ctaaagtatt tcaaataatt aactgtatta atactctcat catgattgcg
    14341 ttataaacgt tcgttattga gacaaaattt aatagtacta ctacacaaaa agagagtgcg
    14401 aattcgcact ctctttttgt gataaatgaa tggttaagaa aataattcat ccacagttgt
    14461 atcaaacaat cttgccaact taaatgctaa tgtcaatgta ggatcatatt tattgttttc
    14521 tattgcatta atagtttgcc tagacacttt taattcttta cttaaagttt cttgagaaat
    14581 tcctttttgt tttctatatt ctctaattct atttttcatt aatttaacct ttagatgtat
    14641 attttttatt tgtagtatag taattaaaca gcataagaaa tagtgctaca attataaaga
    14701 aaatttctgg atattgagaa aaccaagatc cttcaatact tggtgacaaa cctgtaaatt
    14761 taagcactag tgtaaataac atacaatata caatccaaat aaaactttta gccagtattt
    14821 caataaacat tttacgttgt ctttcatcgt atcgatcttg ttgtcctttt ttatctaatg
    14881 tttctgaagg taaatatttg ttagttatag ccgtccataa acaagaaaaa attaaaataa
    14941 taataaaagg aattaaattc attataacac ctcataaatg taaaaagtat ttgacattta
    15001 tgagtgtaaa tatttttgat acaaatgtca aatacttttt acattataat atattttaaa
    15061 acaccttatt agtaaaacaa ttactatata gaaagctgcg aactcgtact cttttttctt
    15121 gtataattat taaaatctca attcaataat atgttatgga atttgagaca ctgtgagaga
    15181 cgctcatttg cattgacaat caatttatca agataatccc ttatcatgtt taattctata
    15241 aactgtttgt cttgtgatat taacttcttt cgcaatctta ctaatcgctt tgccttcttc
    15301 taacatttcc accacgcgat gataaataac acgtttctgt gggtctttag catttggtga
    15361 ataaagtaaa gggcgccctt tatatacgcc tttttccttc gcaacttgaa tcccttgcgc
    15421 ttgtcgacgt ttactttcat ttctctcttg ttctgaaacc attgctaata tttgaatgat
    15481 taaatctttc ataaacttat ccagtaatgg attgccaatt acttcattca tcataggtaa
    15541 gctggtaatc attaactgaa cgtctttttc ttttaaataa ttcacagttt caataatttc
    15601 atcatagtta cgtcctaaac gatcaataga ttccacaacg aatcgatctc ccattctgac
    15661 aaaattgagt gcttcttgaa atacaggtct attttccact gactttcccg actgtttctc
    15721 tgtaaagatt ttctccacac caaacgtctt taaattatcc aattgtcttt ctaaattttg
    15781 atctatcgat gatactctcg cataacctat aatcattcat cttcactcca taataaatat
    15841 acaccctaat catacgtttt aattgttata atttcaacaa ttctttttgt atggttaggg
    15901 tgtactcaaa gtgtacatat ctataattaa aacttactaa aaataaatat agattttttc
    15961 tttgtaacag aaccgttcat ttgaaggtca tctctatcat aaatatttaa attaactaaa
    16021 aattttaatc atctgtttaa tacttatgaa atgtatttac ggtaggtatt aaaattgatg
    16081 aaatttatat aagtgctttc aatgaaaatg accgtttatt tatcctcctg atttaaggag
    16141 ttagaaattt cgaaaacgat tctttccatt tgttgcattt gttccatgtc cagatattta
    16201 atacattata gaaaaccaaa gaccatcact aattaaacgc agttttaaaa tttcatcagg
    16261 attgccttcg tctttaaaat gggcctcttt taatataagt tctactcttt catacctaac
    16321 tctttcaatg ccatcgtttc atacgccgat tctcctgatt ccatagcaaa ctcagcgata
    16381 aacattggga atactgcatt gagttctatt atatgctctt tcattcgtgg ccatatttca
    16441 cctccagctt taccgtatgc tgttataagt tgctctaatc cttcgtcgtc gaatacacga
    16501 tggtgtccta taaagtccat tgatgggtcg gagtgggttg cttcagtcca gtctatgaga
    16561 cctgtgacgt ttgcttggtt atctaccatt atatgtcctg gatgtaagtc cccatgtatc
    16621 atggtcgcat gtcgaggcca tagttcgtcg ttttctaacc attgtttcca tctgttccat
    16681 aattcatctg atacgccata agtttcttta actttattca ttcttctttg aaagtcattt
    16741 tttatttctt gtatggtttt gatatttata tgctgaacgt taatgttttc ttctggtatg
    16801 ttgtgtaaat ctacgagtgt ttcagctaat gtgttaataa agttttctgg taatggtttg
    16861 tgttcaattt cccatacata attttgtatt tctggatcta ttgtggctgc gggtttacct
    16921 gtaagttttg ggtaagcaat aaggtctttt gcatgtactt tccacttcgg tatttcaaat
    16981 gaaacattct tctgtaagaa gtctaccgtt tgtttttcgg gttttgttcg tttataaacg
    17041 tcaggtcttc ttggtagtct caaaacccat tctactccat gtttatcttt tccaaatgca
    17101 acttgaaaat caagtcccga ttcattcaat gagattgttt gaggttggat gtgtaattga
    17161 tatttttctg cacatttaat aatttcatta tgtcgagtca ttttattgga tccttatttc
    17221 tattatattt ttcttgtgaa cgtatttttt atattgatat aaatgaacct aatattcaat
    17281 ataaattagt gtatagtttt taagttatat catgaagaga ttgtcctgtt aattcccatt
    17341 ttttatctga tacatgttta acaaaccttg tatcatgtga tgtaaacaaa atgattccag
    17401 gatatttatt cataaacatt tctaatgctt ctaatgtttt aatatctaaa aaattagttg
    17461 gttcatccaa aattaacata ttcgctttcg ttgaaaataa tactgctaac gataatttcg
    17521 ttctttcccc accactcaaa acattacaag aacgatcaag tgcttcattt aaacccaagt
    17581 tatttaaaat agctctactg aatgattctg atgaatccgt ttcatccatt aaatattgca
    17641 ataatgaaac gtcacgcatg tcttcataag caagttgacg atagtatgcc atttgcactt
    17701 taggagaaca atcaattccc tctatttggt ggtaaatagc ttcaagtaaa gttgtcttac
    17761 ctacaccatt tgcacctacg agcgctatat ttttgccata tggtatttgg aatcgtactt
    17821 gtgttagcag tttttgactt cctttaacca atgttagatt ttgtgcaatg attggataat
    17881 tattatggat atcataaatt ttattttgtg ggaaattgaa ttcatgataa ctttgtggtt
    17941 tttcaacttc ttccaaatgt tccattcttt tttcaatatg cttagcttgt ttttgagcag
    18001 ccttctcaac cgtgcctttt tgttttgatg cacttaaacg atctggtgct atacttttgt
    18061 ttttttgttt tgatgatgct tgtgccattt gttgcgcttg atttcgttta gctttactgg
    18121 cttgggacaa tctttgtttt tcacttatat actgttcata ttgacgttgt tgttctaact
    18181 gttcttgttc atattgattt tgatactgtg tgtaattacc tttaaacact cttattgtgc
    18241 catcttcttg tatatcccaa attgtgtcag caatttggtc tataagtgct ctatcatgac
    18301 ttactataat taaagtacca tagtaatatt ttaaaatatt tttcagataa tctttaccaa
    18361 ttttatccaa gtgatttgta ggttcatcta aaagtaatat cggactataa tttgatatga
    18421 cattagctaa tttatatttt gctttttcac caccactcat actgtcggtt gtatgcatag
    18481 gtatatggag ttcactcatt aaactaccgt ctaacgtgtt aaaatcattt tccacatcca
    18541 tgttaagctg ttcaaaatat tgaatttcgc caaccgtttc aactgttcca gattctggtt
    18601 ttgttttttg agcaatcata tttagtaatg tggttttgcc agtaccatta cccccaataa
    18661 gtgctatttt ttcaaattgg taagcgtaaa gatgaccgat gttaagtgat cgtaaatctg
    18721 tcaatttatg attgatttgg ttaaatttaa ttgtatattg ttccatattt atacactcct
    18781 tgtatattta aaggacgtgt acgcaaaaaa atgagacagg ctactcccgt ctcattcaca
    18841 ttacactttc aaacacttaa aaatttatta tgatgtttta gtatttgaaa gcgtttatta
    18901 ttcctatcga aggataaaaa atgacataag tcatcctatg agtgtgtatt gcggacaagc
    18961 ctttttgaat taatttagtt ttgtattcaa aaaggtttat ttgagtctca tagaagctgt
    19021 cattttaatc ctccttcatc gataaaatag taatgttaat ataacatttt gttggttttt
    19081 ttacaatata tctctaagta gaaagattat ataacaaaag tataaaaata caattttaga
    19141 ttgattatac atctccttaa tttagagtgt actcataaaa tacggttctg ttgcaaagtt
    19201 gaatttataa tataatttta acaaaaagga gtcttctgta tgaactattt cagatataaa
    19261 caatttaaca aggatgttat cactgtagcc gttggctact atctaagata tgcattgagc
    19321 tatcgtgata tatctgaaat attaagagaa cgtggtgtaa acgttcatca ttcaacgatc
    19381 taccgttggg ttcaagaata tgccccaatt ttatatcaaa tttggaagaa aaagcataaa
    19441 aaagcttatt acaaatggcg tattgatgag acgtatatca aaataaaagg aaaatggagc
    19501 tatttatatc gtgccattga tacagaggga catacattag atatttggtt gcgtaagcaa
    19561 cgagataatc attcagcata tgcgtttatc aaacgtctca ttaaacaatt tggtaagcct
    19621 caaaaggtag ttacagatca ggcaccttca acgaaggcag caatggctaa aataattaaa
    19681 gcttttaaac ttaaacctga ctgtcattgt acatcgaaat atctgaataa cctcattgag
    19741 caagatcacc gtcatattaa agtaagaaag acaagatatc aaagtatcaa tacggcaaag
    19801 aatactttaa aaggtattga atgtatttac gctctatata aaaagaaccg taggtctctt
    19861 cagatctacg gattttcccc atgccacgaa attagcatca tgctagcaag ttaaacgaac
    19921 actgacatga tatattagtg attagctata ttttttactt tgcaacagaa ccagccattt
    19981 aatatgactg ttacaattac taagattcaa gcactattac gccgcacgta tgatttcacc
    20041 actcaagtta ataatttaac agtagatgat tgcgagttac tacttgatgc agcaaagctt
    20101 aaatttaatg aagaaaccat agacctgaca cacactgaat tgcaaatcat gcatagctta
    20161 ttccagaaca agggcaaatt cgtcagtcgt aatgcgttaa tcgaaaaatg ctgggaatca
    20221 gaacacttca ttgatgacaa tacgcttgct gtcaacatta cacgtttacg caaaaagcta
    20281 caaaaactag gacttacaga ttttatcgaa acgaagaaaa atgtcggata tcgtgtaggt
    20341 gacgtatgaa tttcttgaaa tcaatccaac gtgaaattta tattgtcatc cttacttgtg
    20401 ctttattcta ctttatatta ttcatgtata atgtgccgat gcaagcatat atgattggtc
    20461 taggtattgt attgtttgtt tcaatgattt actggggtat ccattacatg aactttaaaa
    20521 aagaataaac actacaggaa cagaacgaag atttaagaat cgaaaaccat aaacttcgta
    20581 atgactttat taactaccaa agtgagttag agtcatattt tttaatgtgg gtgcatcaaa
    20641 tcaagacacc gattacagca tcaaagttac tgcttgaaga tcctgatgaa cacgtgattt
    20701 ctaacgtgcg taatgaagtc ttacaaattg ataattacac gaatcttgca ctgaactatt
    20761 tgaaactcat gaaccaaaag acatacatgg tctttatgga agtgagtgta gatgaattaa
    20821 ttcgaccact gattaaacgt tatgcgatac agtttattca tcatcaaaca aagttgcatt
    20881 atgagaaaag tgaagcggtt atattaacag atgccaaatg ggcatcaatt atgattgagc
    20941 aaatattaaa caatgcatta aaatatgcac gtggcaaaga tgtgtggatt acgtttgacg
    21001 aaaatacaaa gaaattatca atccgagata acggtatcgg cattaatgcg agtgatttac
    21061 cgaaaatctt tgataaaggt ttctcgggct ataacggtag aataagtgag aaatcaagcg
    21121 gtattggttt atatattgtc agcacaatct caaagcgctt aggccataaa gtaagtgcta
    21181 catctacatt aaacgatggt tcaatattca ccattcaatt taaataactc caatctttca
    21241 tttttgtaag attagcggct gtttttgtaa gaatagataa aggcagcctt ttctaatcgc
    21301 gcgtaagata aaggtaacaa caaactaaga aaggtgccag aggtgaaaaa tttgaataat
    21361 ataattgaaa taaataactt aacaaagcaa tatggaagtc agatagcagt taataatttg
    21421 agtataactg ttgaaagtgg acaaatttat ggttttttag gaagaaatgg tgcaggcaaa
    21481 acaactacta taagaatgct tttaggctta attaaaccta cgaaaggtaa tattaaaata
    21541 tttgaaaaag agttcgaaag taataaaact gaaattttaa aaaatattgg tgctatggtt
    21601 gaaacgccag gtttttatag taatttgaca gctaaagaga acttaactat aaatgctaaa
    21661 atattaggta tacaaaaaga aaatgcaatt gaagaagtgt tagaaatagt aggactagct
    21721 tctgaaaaag taaaattgtt taaaaattat tctttaggta tgaagcaacg tttagggatt
    21781 gcgagagctt tattgcacaa tcccgaatta ttgatacttg atgagccgac gaatggatta
    21841 gatcctattg gcataaaaga aattagaaag ttgattaagg atctggctca atctagaaat
    21901 ataaccattt taatttcaag tcatatattg tcagaaatag agcagttagt agacaaggtg
    21961 ggtattattc ataacggagt tttgttagaa gaaattatgt atgaagattt aaaaaaaaag
    22021 aacagacaat ttataagtat atcagtatca gatgaagaaa aagttgcatg tttgttggaa
    22081 actaacttcg gaatttatga ctataaaatt aaagaaaatg gcgaatttaa aatttattca
    22141 catattgata gacaacaaga aattaataga ttattagtat taaacaatat tgatgttttc
    22201 cagatgagag tgatagaaga taatctagaa acttatttcg aagacttagt aggaggtggc
    22261 acaattggat aatctactcc gtacagaatt tattaagtta aaaagatcat atatgtttct
    22321 aataagtatt ttaggtacat gcgtagcacc ttttatggtg gttgtagctt cttttattag
    22381 tatgcggacg aaagtaccga ctcctaatat tgtatttaaa cagttatttg aagaagtcag
    22441 tttatatcat atgctaatta ttggacctcc tctatatggg gttataatag cctatttgtt
    22501 tggaagagaa tatatagaag atactttaaa aaacttatta attataccta tatctagaga
    22561 aagtttttta gtaagtaaaa taatattatt attcttgtgg attcaaacac tatctgttat
    22621 tgcatggttg ctaactttaa tgctaggtat gctattgcat tttcaagggt taagccagag
    22681 tttaataatt gattcattct ttacatttgt tattggcgga gtgttattat ggatattatc
    22741 tccaccaata attattttgt cgatatattt taaaaattat gttcccacaa ttgttttaac
    22801 cataataatt actttgataa atttaatgac tgctaattct gaacatagag gattatttcc
    22861 ttgggctgca gttggagaca tatctagagg aacattacct aatacttatc catttctatt
    22921 atctttaatt atcataattg ttacatctat attcagtgta attatattat tctcatactt
    22981 taaaaaaact gatataagtt aaaaggagga gaaaaatggg ttttatagag cagattaaag
    23041 catttatttt aggtgtagtt gaagggttga cagaatttgc tccagtatca tcaacaggtc
    23101 atatgattat tgttgatgat atgtggttaa acactgctga cgatttagga agtgcgtctg
    23161 caactacttt taaggtggta atacagttag gaggttctgt tgcaaagttg aatttataat
    23221 ataattttaa caaaaaggag tcttctgtat gaactatttc agatataaac aattt
//
