LOCUS       CP151566               18658 bp    DNA     circular BCT 21-APR-2024
DEFINITION  Staphylococcus aureus strain BSN126 plasmid pSh29970, complete
            sequence.
ACCESSION   CP151566
VERSION     CP151566.1
DBLINK      BioProject: PRJNA1048360
            BioSample: SAMN38637704
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 18658)
  AUTHORS   Berti,A.D., Gurdziel,K. and Liu,W.
  TITLE     Pre-publication release of Staphylococcus aureus str BSN126 whole
            genome sequence
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 18658)
  AUTHORS   Berti,A.D., Gurdziel,K. and Liu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-APR-2024) Pharmacy Practice, Wayne State University,
            259 Mack Ave, Detroit, MI 48201, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2024
            Assembly Method                   :: SPAdes v. FEB-2024
            Assembly Name                     :: BSN126
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly :: CP030326, GQ900404, CP027493, CP014447,
            CP035293, CP043301
            Genome Coverage                   :: 97.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/15/2024 11:16:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,071
            CDSs (total)                      :: 2,989
            Genes (coding)                    :: 2,901
            CDSs (with protein)               :: 2,901
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 88
            CDSs (without protein)            :: 88
            Pseudo Genes (ambiguous residues) :: 0 of 88
            Pseudo Genes (frameshifted)       :: 45 of 88
            Pseudo Genes (incomplete)         :: 44 of 88
            Pseudo Genes (internal stop)      :: 29 of 88
            Pseudo Genes (multiple problems)  :: 28 of 88
            ##Genome-Annotation-Data-END##
            Bacteria and source DNA available from Andrew D. Berti, Wayne State
            University, Detroit MI  USA.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..18658
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="BSN126"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pSh29970"
                     /geo_loc_name="USA: Detroit, MI"
                     /lat_lon="42.33 N 83.05 W"
                     /collection_date="2021-09-19"
                     /collected_by="Andrew D. Berti"
     gene            1..936
                     /locus_tag="UXR65_15245"
     CDS             1..936
                     /locus_tag="UXR65_15245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WZO01178.1"
                     /translation="MPNFEKYNLSQVKTERFYQLPKYLFEDAYFKKMSAEAKIMYALLK
                     DRFELSIQNEWVDKNNNIYFIFSNKHLCEYLGYAEQKIIKLKKELISFNLLTQERVGLN
                     KPNRLYLLKPNYDIKASHSKELPNSQFQNNEFGSSRTVNLSGQELPNSQSNDTENNDTD
                     YIKTESNDTNDLNDNKLTFPSNHTNHSNHDNSNFNNEALKFQLLEELPQSIKNYLSNFE
                     VAEIKIIKTVLLKAKTSFNNAIDSYYLLEDMEIEILHVLKRFKAMLIQKNETVESMQGY
                     LMKSLKSEFAEMHTLNKRRDHLPITSLFNQ"
                     /name="replication initiator protein A"
     gene            2630..2755
                     /locus_tag="UXR65_15250"
     CDS             2630..2755
                     /locus_tag="UXR65_15250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rep protein"
                     /protein_id="WZO01179.1"
                     /translation="MTVYFYIWIKKEYLASEIFDLTESEKQEINHQMIDEIEEEK"
                     /name="Rep protein"
     gene            complement(3230..3604)
                     /locus_tag="UXR65_15255"
                     /pseudo=""
     CDS             complement(3230..3604)
                     /locus_tag="UXR65_15255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]; GO_process: GO:0006313 - DNA transposition [Evidence
                     IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /name="IS6-like element IS257 family transposase"
     gene            3662..4336
                     /locus_tag="UXR65_15260"
     CDS             3662..4336
                     /locus_tag="UXR65_15260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004803 - transposase activity [Evidence IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WZO01180.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHPLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMAKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(4411..4611)
                     /locus_tag="UXR65_15265"
     CDS             complement(4411..4611)
                     /locus_tag="UXR65_15265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015387322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WZO01181.1"
                     /translation="MIIEQLKQELELNTVNSIEVYFHSGDSVIARKIDYSQSSEKIIKV
                     LNPVPMYINLENVTYIQLREM"
                     /name="hypothetical protein"
     gene            complement(4799..5284)
                     /locus_tag="UXR65_15270"
     CDS             complement(4799..5284)
                     /locus_tag="UXR65_15270"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015387321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0008753 - NADPH dehydrogenase (quinone) activity
                     [Evidence IEA]; GO_function: GO:0010181 - FMN binding
                     [Evidence IEA]; GO_function: GO:0050136 - NADH
                     dehydrogenase (quinone) activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="WZO01182.1"
                     /translation="MNFNPVAQKSDFKYLKNNNFFKYPIEQEHSYKNNILSKEIKSELS
                     KLLWADIIIFQFPLWWSSVPAILKGWFDKVLIYGGIYGGAYGKFKNARLSNKKAIISTT
                     TGSSGDIHKQVLFHISHGIVEYTGMQCLDTLIAYEIDKDQNSRDEYIEFFKNKIKYI"
                     /name="NAD(P)H-dependent oxidoreductase"
     gene            complement(5295..5408)
                     /locus_tag="UXR65_15275"
     CDS             complement(5295..5408)
                     /locus_tag="UXR65_15275"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="WZO01183.1"
                     /translation="MNILIVYAHPEPQSFNSKLKDIAQTVLKENGNNCRCI"
                     /name="NAD(P)H-dependent oxidoreductase"
     gene            complement(5447..6907)
                     /gene="zwf"
                     /locus_tag="UXR65_15280"
     CDS             complement(5447..6907)
                     /gene="zwf"
                     /locus_tag="UXR65_15280"
                     /EC_number="1.1.1.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360133.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004345 - glucose-6-phosphate dehydrogenase activity
                     [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate
                     shunt [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate dehydrogenase"
                     /protein_id="WZO01184.1"
                     /translation="MDKNLSSLITIFGGTGDLSYRKLLPSIFNLYKKGHFKKLVIISTG
                     LEDISDEEYRSKVKQILLSQENFEMVNLFLDNIFYFQQNVEDKTSWNKLKELSNDIDKK
                     YCLDGNRLFYLAMNPQFFKIITQSISQSGLSDTNGFSRLIIEKPFGKDLKSAEDLNKHI
                     RQYFKEEEIFRIDHYLGKEMVQNIESLRFGNTIFEPLWNNKYISNVQITLSETLGIEDR
                     GQYYDSTGALKDMVQNHALQILTLIAMEKPESRNSKDIRLKKIELLNNIKFLKGADVHK
                     YFVRGQYINGIINETPIMSYHEEKGVNSDSTTETFVAGKLLINNDRWKGTPFYIRTGKR
                     LNKKAIEVVIEFKKLNSKLIYENDNEDVDCNLMVINIEPNAQISLYIYENKSTRNNRNH
                     NIQIYNLIDKKQVVDAYESLICDALIGNQTNFVHWEELKHSWEFIDYISTEWKKSNVTI
                     PQYKPGSFGPKESDQLLKQDNFEWWNNL"
                     /name="zwf"
     gene            complement(6971..8377)
                     /gene="gndA"
                     /locus_tag="UXR65_15285"
     CDS             complement(6971..8377)
                     /gene="gndA"
                     /locus_tag="UXR65_15285"
                     /EC_number="1.1.1.44"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004616 - phosphogluconate dehydrogenase
                     (decarboxylating) activity [Evidence IEA]; GO_function:
                     GO:0050661 - NADP binding [Evidence IEA]; GO_process:
                     GO:0006098 - pentose-phosphate shunt [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent phosphogluconate dehydrogenase"
                     /protein_id="WZO01185.1"
                     /translation="MSSNIGILGLGVMGKNLAWNIEDKKYSVSIHSRDNNEINDTIQKS
                     HYQKIYPAYNLKEFVDSLEKPRKILLMIKAGSPTDNMINALLPLLDDEDILIDGGNTNY
                     QDTIRRNKTLAESGVNFIGMGVSGGEVGALTGPSLMPGGQEAAYNKVSDILDAIAAKAQ
                     DGASCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYTMMKDLLGMSHTEISQTFKDWN
                     AGELESYLIEITGDIFTKLDENNEPLVEKILDTAGQKGTGKWTSINALELGIPLTIITE
                     SVFARFISSIKEERVNASKSLNGPQASFDGNKEEFLEKIRKALYMSKICSYAQGFAQMR
                     KSSEDHEWNLKLGELAMIWREGCIIRAQFLQKIKDAYDNNPELENLLLDPYFKNIVTDY
                     QDALRDVVATGVKNGVPTPGFSASVNYYDSYRSEDLPANLIQAQRDYFGAHTYERKDRE
                     GVFHTQWDEE"
                     /name="gndA"
     gene            complement(8409..9740)
                     /locus_tag="UXR65_15290"
     CDS             complement(8409..9740)
                     /locus_tag="UXR65_15290"
                     /EC_number="5.3.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_499453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004347 - glucose-6-phosphate isomerase activity
                     [Evidence IEA]; GO_process: GO:0006096 - glycolytic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="WZO01186.1"
                     /translation="MTHIQLDYGKTLEFFGEHELEQQKDIVKTLHKTIHEGTGAGNNFL
                     GWVDLPVDYDKEEFSRIVEASKRIKANSDVLVVIGIGGSYLGARAAIEMLTSSFRTNND
                     YPEIVFVGNHLSSSYTKELVDYLADKDFSVNVISKSGTTTEPAVAFRLFKQLVENKYGK
                     EEAKKRIFATTDKQKGALKQLATNEGYETFVVPDDVGGRYSVLTAVGLLPIAAAGINIE
                     AMMIGAAKARKELSSDKLEENIAYQYATIRNLLYSKGYTTEMLINYEPSMQYFNEWWKQ
                     LFGESEGKDFKGIYPSSANYTTDLHSLGQYVQEGRRFLFETVVKVNHPKHDLTIEEDSD
                     DLDGLNYLAGKTIDEVNTKAFEGTLLAHTDGGVPNIVVNIPQLDEETFGYVVYFFELAC
                     AMSGYQLGVNPFNQPGVEAYKQNMFALLGKPGFEDMKKDLEARL"
                     /name="glucose-6-phosphate isomerase"
     gene            9941..10573
                     /gene="hxlA"
                     /locus_tag="UXR65_15295"
     CDS             9941..10573
                     /gene="hxlA"
                     /locus_tag="UXR65_15295"
                     /EC_number="4.1.2.43"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019834869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0043801 - hexulose-6-phosphate synthase activity
                     [Evidence IEA]; GO_process: GO:0019647 - formaldehyde
                     assimilation via ribulose monophosphate cycle [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-hexulose-6-phosphate synthase"
                     /protein_id="WZO01169.1"
                     /translation="MELQLAIDLLNKEEAAELAKKVEEYVDIVEIGTPIVINEGLPAVQ
                     HLNENINNAKVLADLKIMDAADYEVSQAVKFGADVVTILGVAEDASIKAAVEEAHKNDK
                     QLLVDMIAVQDLEKRAKELDEMGADYIAVHTGYDLQAEGQSPLDSLRKVKSVIKNSKVA
                     VAGGIKPDTIKEIVAEEPDLVIVGGGIANADDPVEAAKQCRDAIEGK"
                     /name="hxlA"
     gene            10576..11124
                     /gene="hxlB"
                     /locus_tag="UXR65_15300"
     CDS             10576..11124
                     /gene="hxlB"
                     /locus_tag="UXR65_15300"
                     /EC_number="5.3.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002505085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0043800 - hexulose-6-phosphate isomerase activity
                     [Evidence IEA]; GO_process: GO:1901135 - carbohydrate
                     derivative metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-3-hexuloisomerase"
                     /protein_id="WZO01170.1"
                     /translation="MTTFNHYQLILDELKGTLSHVKDEEFDGFASEVTEASRIFVAGKG
                     RSGFVANSFAMRLNQLGKQAFVIGESTTPSIQKDDLFIVISGSGSTEHLRLLAEKAKSV
                     DAKVVLLTTKLDSAIGEIADTVVELPAGTKHDATGSDQPLGSLFEQSSQIFLDSVVIGL
                     MTQLDIDETTMQNNHANLE"
                     /name="hxlB"
     gene            11213..11545
                     /locus_tag="UXR65_15305"
     CDS             11213..11545
                     /locus_tag="UXR65_15305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000291486.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WZO01171.1"
                     /translation="MYYKGKEFFTSKDLALCVIGGKWKIPIIFHLLQDKVLRLSELQKK
                     LPHVNQRMLIRQLRELEEDQIIERHIYSVVPPKVEYKLTSIGYKLDKVVYAICEWGDLF
                     KDEIIH"
                     /name="helix-turn-helix domain-containing protein"
     gene            complement(11710..12385)
                     /locus_tag="UXR65_15310"
     CDS             complement(join(11710..12069,12071..12385))
                     /locus_tag="UXR65_15310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001015311.1"
                     /ribosomal_slippage=""
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology. GO_function: GO:0004803 - transposase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WZO01172.1"
                     /translation="MNYFRYKQFDKDVITVAVGYYLRYALSYRDISEILRERGFDVHHS
                     TIYRWVQEYAPILYQLWKRKHKKTYYKWRIDETYIKIKGQWCYLYRAIDAGGHTLDIWL
                     RKKRDHQSAYAFIKRLIKQFGKPQMIITDQAPSTKVAMAKIIKVFKLKPNCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSVNTAKNTLKGIECIYGLYKKSRRSLQIYGFSPCHEISYML
                     AG"
                     /name="IS6 family transposase"
     gene            complement(12440..12748)
                     /locus_tag="UXR65_15315"
                     /pseudo=""
     CDS             complement(12440..12748)
                     /locus_tag="UXR65_15315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001106057.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]; GO_process: GO:0006313 - DNA transposition [Evidence
                     IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(12863..13177)
                     /locus_tag="UXR65_15320"
     CDS             complement(12863..13177)
                     /locus_tag="UXR65_15320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002316685.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]; GO_process: GO:0006355 - regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WZO01173.1"
                     /translation="MKSSSTSPLTNDSIQEVSKIFKMISDPTRLSILFLLQKEELSVGV
                     IAQSLSMEQSAISHQLKTLKTSRLVKSKRVGKNMIYSLDDLHIFSILEQVSTHIGEQEK
                     "
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            13431..15350
                     /locus_tag="UXR65_15325"
     CDS             13431..15350
                     /locus_tag="UXR65_15325"
                     /EC_number="7.2.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017175150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0005524 - ATP binding [Evidence IEA]; GO_function:
                     GO:0015662 - P-type ion transporter activity [Evidence
                     IEA]; GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]; GO_function: GO:0019829 - ATPase-coupled
                     monoatomic cation transmembrane transporter activity
                     [Evidence IEA]; GO_function: GO:0046872 - metal ion binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="WZO01174.1"
                     /translation="MKEIQEQHSHENNSHDHDHDHGKMPIILYFIGLALALIAFFLSKE
                     YQILQNILFLIATISAGYHVIVLEGLGETIHNSKSQKRFIPNSHILMGLAAIGASLMGN
                     FGEGALLIFIFSGAHFLEDYAEGRSRREITKLLEMNPTTARLILPDGSTKNVKVNELKV
                     GNHLQVLNGDQVPIDGIILSGSTSIDESSINGESIPKEKSKGDEVFGSTINGTGTFTME
                     VTKENKDTVFSKILQLVNQNQDNQTKAASIIQKFEPKYVTFVLVAILLFILLTPFLLDW
                     TWSQSFYRGLVLLVAASPCALAAATVSATLSTTSNLAKKGVLSKGSSYLSQLADIQAIA
                     FDKTGTLTKGKPEVTNHYFTDSMDEEEIIDIVVALEKNSNHPLADAILRKFEPKNQLSI
                     EVENQIGKGLSGDYNGRKYRIGKPTSFDDVSDEYVRLNNQWASEGKTVVYLAVDEEVIG
                     LIALMDVPSKYAKETIEYFNKQGIHTTLITGDSEMTGKAVASKLGIDEVIANVMPDEKS
                     KIIDKQKEKYGVTAMVGDGVNDAPALVNADVGIAMGDGTDVAVEVSDLVLMQNNLTKLT
                     QSHKISTKMNRLIWQNIIFSMAVVAFLIIVSLVGLTDIAISVIVHEGSTLVVILNGLRL
                     LNSK"
                     /name="heavy metal translocating P-type ATPase"
     gene            15473..16147
                     /locus_tag="UXR65_15330"
     CDS             15473..16147
                     /locus_tag="UXR65_15330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004803 - transposase activity [Evidence IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WZO01175.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILSERGVNVHHS
                     TVYRWVQEYASILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMAKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(16189..17115)
                     /locus_tag="UXR65_15335"
     CDS             complement(16189..17115)
                     /locus_tag="UXR65_15335"
                     /inference="COORDINATES: protein motif:HMM:NF014975.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0009036 - type II site-specific deoxyribonuclease
                     activity [Evidence IEA]; GO_process: GO:0009307 - DNA
                     restriction-modification system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease FokI catalytic
                     domain-containing protein"
                     /protein_id="WZO01176.1"
                     /translation="MTIRSFGWVQNPSDFKKLKQTVEIFSKNSKQYQLLKESLIKEKLH
                     NFKDIQSSLQEKLNDGIEEFSYIELVGKNLGKDRKTPKSRKYSLPNALIQISLDSQSAS
                     TKNKHFTDEWSSDGFLRWAVSLNFVEQNRQTDIFKITSRGKQFIETQNEVEMNKVLREA
                     FLSYPPATRVLEILNNNTEVTKFFIGNRLGFKDEPGFTSYSEELMLDWIKESENKKEEL
                     KIRSDVEGTADKYARMICGWLKKVGFVSQKSIQYNSLLEKNRKITGFSLYSITAKGSHA
                     LRQAQGNSSNSKREKFVMWEFLGSVAK"
                     /name="restriction endonuclease FokI catalytic
                     domain-containing protein"
     gene            complement(17452..18219)
                     /locus_tag="UXR65_15340"
     CDS             complement(17452..18219)
                     /locus_tag="UXR65_15340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002489261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WZO01177.1"
                     /translation="MRTIKMVADELGVTKQTIVNNAKSLNITFEKENGINYIDDNDYLK
                     IIEKITKKESTIQNKESVKKELFGENTAKAEKNIYNNSNSSETLKTKVNELEKQIEIFE
                     TRAKNDEKYIENLTKQLDQQNSNVNTLNKLLENQQILALESNKKIQKLESQLEEERQLN
                     YSFDTATNNRQNINPQEATFTEESQNINQQQTKRQPTEVNYKDIAEEKKNDSTDEGELT
                     KEDKFVEETKSDPDDNREVEPPKKGFWSRFFGN"
                     /name="DUF536 domain-containing protein"
     Typing          2..936
                     /name="rep_cluster_1215"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.893"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 atgcccaatt ttgaaaaata caatttatca caagtaaaaa ctgaaaggtt ttatcaacta
       61 cctaaatatt tattcgaaga tgcatatttt aaaaaaatgt cggcggaagc caaaattatg
      121 tatgcgttat taaaagatcg ctttgaatta tccatccaaa atgaatgggt agataaaaat
      181 aataacattt actttatttt cagtaataaa catttgtgcg aatacttagg ttatgcagaa
      241 caaaaaatta taaaattaaa aaaagagtta ataagtttta atttactaac tcaagaacgt
      301 gttggcctta ataaaccaaa tagattatat ttattaaaac ctaattatga cattaaagcc
      361 agtcatagca aggaacttcc aaattcacag ttccagaaca atgaatttgg aagttctaga
      421 actgtgaatt taagtggtca agaacttcca aattcacagt ctaatgatac tgagaataat
      481 gatactgatt atattaaaac tgagagtaat gatacgaatg atttgaatga taataaacta
      541 acttttccta gtaatcatac aaatcattca aatcacgaca attcaaactt taataatgaa
      601 gctttaaaat tccaattact cgaagaatta ccacaaagta ttaaaaacta tctaagtaac
      661 tttgaagtag ctgaaattaa aattatcaaa actgtattat taaaagccaa aacatctttc
      721 aataatgcga ttgatagcta ctacttgtta gaagatatgg aaatagaaat acttcatgtt
      781 cttaaacgtt tcaaagctat gcttattcaa aaaaatgaaa ctgttgaatc aatgcaagga
      841 tacttaatga aatctcttaa gtctgaattc gctgaaatgc atacgcttaa taaacgacgt
      901 gatcatttac ccatcacttc tttatttaat caataatgat tgatttagag agcatcttta
      961 aatagatgtt ctcttttttt attaacaggt ggttgctaaa gcaaccacct agatcaaacg
     1021 aaaggtaagg gaggagataa caaaataaca tcaatacaat ttcacaacat agcatgctgc
     1081 tattaaagaa aggaggaaga cttatgagta ctaagaaaaa gattaaaatt actttggcaa
     1141 tgattaatgt tcttttaact gcagtcgaac tttatcttca atggcaattg agtaaatctg
     1201 aaaatgaact gtagttaagc aagtaggtag gactaaaacg tttctgtttt agtcctattt
     1261 ttttctataa acggttatta ttcgtttgaa aatggctcaa aaacgtcgca taagatgaaa
     1321 aataaaatga ttatttaacg ttgctttaac tttaaagaat ataaaaacac taaccgtttt
     1381 tatattcttt agcaatcttt cttaattata aaagtgactt aataaaatcg tttttgtcat
     1441 ttattttgtt aatgatcgga aagaaaaagt tgaatttatc attccataaa atcaaaattc
     1501 agattcaatt gatatacatc ataaacaaaa aataagtcgt taatgttcaa aacatgggtc
     1561 gaatgtaatt ttaaatttga ttttttctat cccaaactaa gtaactattt ttacttagtt
     1621 ttctcttttt ttatctccaa ttattttact aacaatgctt attttgaaaa taaaaataag
     1681 cacttaaagt aaaaagtgaa caagagaata gccacttttg tcttaaagca cgttttgttt
     1741 ttggaaatat tacaaacata ataggatttt caaatagtat ttgacatgag cataaggaaa
     1801 tccagtacca cctttggtgg tattcagcat agctgaagga ttgtcttacc gttcgttttg
     1861 cttacttgct ctttgaaatt cactacaagt gttgatataa caacatttat agttaatatt
     1921 aaataaaaat taatcgacat tataaacctt aatattgcat actatttaca attgttacaa
     1981 gaccacttta aattgtttga atactattat ttttgttgat ttcataggct tcagtcatcc
     2041 tcaatcctat aaataggatt aattttttta accaaatcct attaatccta ctacttttag
     2101 tattaatttc aacaacaaaa tcactaaaaa agtaatctaa gcaattcata catttgtttc
     2161 actttttgaa attgattaaa tacttttttc tcaatatcaa attcaataat gatcatatta
     2221 tttattttta agttcaaaaa aagagaaaga ataaaacaat ttctatacgt ttctatgctc
     2281 aattttatta aaaagtgaat cgaaataaag atcattttat ctttttatta actagagaat
     2341 taaaaaatat aaaatgcata ataagattca tcgaaaggat tatactcaaa attttttatt
     2401 ttaatcttcc tgaattttaa attcaactct tatttacgtt ttaagagata tgaaattatt
     2461 tttttgtata acaatatata acattctaat tattttagtg agtatcaaga ttattttaat
     2521 taactttaaa atgttaaata aaaagcaaag tattatttat tttagactgt ctaaagaaat
     2581 aaaatagaac ggaaaacatg ccaaatggca ttttctaaaa gaaggtgatt tgacagtata
     2641 tttttatatt tggattaaaa aagagtattt agcgagtgaa atttttgatt taacagaaag
     2701 tgaaaaacaa gaaattaatc atcaaatgat tgatgaaatt gaagaagaaa aataaaaata
     2761 aattttctta aacgttagca aaaagctagc gtttttttgt tgaaaacacg ctaaaaatgg
     2821 ctgggtacat tttgggtaca gacacaatat gatgtgggta caaaatgggt acaacacaat
     2881 atcttgtggg tacattctgg gtacaaaaca aaaaaatgta taccttttta aaatctctgt
     2941 atcccttgaa atgtctggct tcgccagacc taccatttaa aatggtagca aatttccctt
     3001 atgctcttac aaagaatttg gagccaattc aaaattcggt ggttttttga aagaaattgc
     3061 tcctgcagga actaaaaaag ttgatgattt tttgagccat tttatgcaaa attttagttt
     3121 gcatgtaact gggcagtgtc taaaaaatcg tcactggttt tgctcagatt ggttctgttg
     3181 caaagtaaaa aaatatagct aaccactaat ttatcatgtc agtgttcgct taacttgcta
     3241 gcatgatgct aatttcgtgg catggcgaaa atccgtagat ctgaagagac ctgcggttct
     3301 ttttatatag agcgtaaata cattcaatac cttttaaagt attctttgct gtattgatac
     3361 tttgatacct tgtctttctt actttaatat gacggtgatc ttgctcaatg aggttattca
     3421 gatatttcga tgtacaatga cagtcaggtt taagtttaaa agctttaatt actttagcca
     3481 ttgctacctt cgttgaaggt gcctgatctg taattacctt ttgaggttta ccaaattgtt
     3541 taatgagacg tttgataaac gcatatgctg aatgattatc tcgttgctta cgcaaccaaa
     3601 tatctggttc tgttgcaaag ttgaatttat agtataattt taacaaaaag gagtcttctg
     3661 tatgaactat ttcagatata aacaatttaa caaggatgtt atcactgtag ccgttggcta
     3721 ctatctaaga tatgcattga gttatcgtga tatatctgaa atattaaggg aacgtggtgt
     3781 aaacgttcat cattcaacgg tctaccgttg ggttcaagaa tatgccccaa ttttgtatca
     3841 aatttggaag aaaaagcata aaaaagctta ttacaaatgg cgtattgatg agacgtacat
     3901 caaaataaaa ggaaaatgga gctatttata tcgtgccatt gatgcagagg gacatccatt
     3961 agatatttgg ttgcgtaagc aacgagataa tcattcagca tatgcgttta tcaaacgtct
     4021 cattaaacaa tttggtaaac ctcaaaaggt aattacagat caggcacctt caacgaaggt
     4081 agcaatggct aaagtaatta aagcttttaa acttaaacct gactgtcatt gtacatcgaa
     4141 atatctgaat aacctcattg agcaagatca ccgtcatatt aaagtaagaa agacaaggta
     4201 tcaaagtatc aatacagcaa agaatacttt aaaaggtatt gaatgtattt acgctctata
     4261 taaaaagaac cgcaggtctc ttcagatcta cggattttcg ccatgccacg aaattagcat
     4321 catgctagca agttaagcga acactgacat gataaattag tggttagcta tattttttta
     4381 ctttgcaaca gaaccatgct atctacatta ttacatttct cttaactgaa tgtatgttac
     4441 attttctaaa ttaatataca taggcactgg attaagtact ttaataattt tttcagaact
     4501 ttgtgaatag tctatttttc ttgcaattac tgaatctcca gaatgaaaat aaacttctat
     4561 actatttact gtatttaatt ctaattcttg ttttaattgc tctattatca caaacaaaaa
     4621 ctcctttcca aattattttg aaaaaccaca ttttaaatta attactgtgt cttctggttt
     4681 aataatattt ttaacacatt ctgagaatac ttccctataa tagcccatac aagtgtttta
     4741 tgctttaata aatcaatgac ttagcttttt tatttctcta ctccgtattt caatttggtt
     4801 aaatatactt tattttgttt ttaaaaaatt ctatatactc atctctacta ttttgatctt
     4861 tatcaatttc atatgcgatt aatgtatcta aacattgcat tccagtatat tcaactattc
     4921 catgactaat gtgaaatagt acttgtttgt gtatatctcc tgatgaacca gttgttgtac
     4981 ttataatagc ttttttatta gataatctgg cgttcttaaa cttcccatat gcccctccat
     5041 aaatccctcc atatattaaa actttatcaa accatccttt taatattgca ggaacactcg
     5101 accaccataa agggaattga aaaataataa tatccgccca caatagtttg cttaattcag
     5161 atttaatttc cttacttaat atattatttt tgtaagaatg ctcttgttct ataggatatt
     5221 taaaaaagtt attatttttt aaatatttaa aatcagattt ttgagcaaca gggttaaaat
     5281 tcattttata caaatcagat acaacgacaa ttattaccat tctccttcaa tactgtttgt
     5341 gcaatatctt taagtttact attaaaagat tgaggttcag ggtgcgcata tactattaga
     5401 atattcattt aacttctcct atatagtgtt ttgcaatatt tacgttttat agattattcc
     5461 accattcaaa gttatcttgt ttaagtaatt gatcactttc tttaggtcca aaacttcctg
     5521 gtttatactg tggtattgtt acgttagatt ttttccattc agtacttata taatctataa
     5581 attcccatga atgtttaagt tcttcccaat gtacaaaatt agtttgattt cctattaaag
     5641 catcacatat aagtgattca taagcatcca ctacttgttt tttatctatt aagttataga
     5701 tttgtatatt atggtttcta ttatttctag ttgatttatt ttcataaata tatagtgata
     5761 tttgggcatt aggttctata tttattacca ttaaattaca atcaacatct tcattatcat
     5821 tttcatagat taatttacta tttaattttt taaattctat aacaacttct attgcttttt
     5881 tatttaaacg ctttcctgta cgaatataaa acggtgtccc tttccatcta tcattattaa
     5941 tgagtaattt ccctgctaca aatgtttctg ttgttgaatc actattaaca cctttttctt
     6001 catgatatga cattatcgga gtttcattaa taataccatt aatatattgt cctctaacaa
     6061 aatatttgtg tacatcagcc cctttcaaaa attttatatt gtttaaaagt tcgatttttt
     6121 ttagtctaat atctttacta tttctgcttt cgggtttctc catagcaata agagtaagta
     6181 tttgtagtgc atgattttgc accatatctt taagcgctcc tgtagaatca tagtattggc
     6241 ctctatcttc aatgcctaaa gtttccgata gagttatttg aacatttgat atatacttgt
     6301 tgttccataa tggttcaaat attgtattac caaaacgtaa agattcaata ttttgcacca
     6361 tctctttacc tagataatga tctattctaa atatttcttc ttctttaaaa tactgtctta
     6421 tgtgtttatt taagtcttca gcagatttca aatcttttcc aaatggtttt tcgattatta
     6481 atcttgaaaa tccatttgta tcagaaagac ctgattggct tatgctttga gttataattt
     6541 taaaaaattg aggattcatt gctaagtaaa ataatctatt gccatccaaa caatattttt
     6601 tatcaatatc attggaaagt tcctttaatt tattccaact tgttttatct tcaacatttt
     6661 gttgaaagta aaatatgtta tctaaaaata agttcaccat ttcaaaattt tcttggctta
     6721 ataaaatttg ttttacttta cttctatatt cttcatcact tatatcctct aaacccgtag
     6781 aaatgataac taatttctta aagtgaccct ttttataaag attaaaaata gaaggtagca
     6841 atttcctgta acttaaatct cctgttccgc caaatattgt tattaatgat gataaatttt
     6901 tatccaaagc agttcccccc ttttacttga ttagctagtt tctggttttc attccgtaac
     6961 agtaattata ttactcttca tcccattgtg tgtggaacac accttcacgg tctttacgtt
     7021 cataagtatg tgcaccaaaa tagtcacgtt gtgcttggat aagattagct ggcaaatctt
     7081 cagaacgata actatcatag tagttcacac ttgcagagaa tcctggtgtc ggtacaccgt
     7141 ttttaacgcc tgttgctacg acgtctctta atgcatcttg gtaatctgta acaatatttt
     7201 tgaagtatgg atctaataat aagttttcaa gttctggatt attatcgtaa gcatctttaa
     7261 ttttttgtaa gaattgtgca cgaatgatac aaccttcacg ccaaatcatt gccagttcac
     7321 ctaattttaa gttccattcg tgatcttcgc tcgattttct catttgcgca aagccttgag
     7381 cgtaagaaca aatcttactc atatataatg cttttctgat tttttctaag aattcttctt
     7441 tattaccatc aaatgaagct tgtggtccat ttaatgattt agacgcatta acacgttctt
     7501 ctttaatgga tgaaatgaaa cgagcaaata ccgattcagt gataattgtt aatggaattc
     7561 ctaattctaa tgcattaata gaagtccatt tacctgtacc tttttgacca gcagtatcta
     7621 atattttttc tactaatggt tcattatttt catctaattt agtgaaaata tcaccagtaa
     7681 tttctattaa gtaactttcg agttctccag cattccaatc tttgaatgtt tgagaaattt
     7741 cagtatgact catacctaat aagtctttca tcattgtata actttcagcg attaattgca
     7801 tatctgcata ttcaataccg ttatgaacca ttttcacata atgacctgca ccatttgggc
     7861 caatgtatgt tacgcaagat gcaccatctt gcgctttagc tgcaatggca tctaagatat
     7921 cactgacttt attataagcg gcttcttgac caccaggcat taatgaagga ccagttaaag
     7981 cgcctacttc accacctgat acgcccatac caatgaaatt aacgccactt tcagctaatg
     8041 ttttatttcg acgaattgta tcttgatagt ttgtattacc accatcaatt aaaatatctt
     8101 catcgtctaa taatggaagt aaggcattta tcatgttatc cgtaggacta ccagccttaa
     8161 tcatcaacaa aattttacgg ggtttttcta atgaatctac aaattctttc aagttatacg
     8221 caggatatat cttttgataa tgagactttt gaatagtatc attaatttca ttattatctc
     8281 tactatgaat actcacagaa tatttcttat cctcgatgtt ccacgcaaga tttttcccca
     8341 taacacctaa acctaaaatt ccaatattac tagacattgt atcctctcat ttctttatag
     8401 tttataacct acaatcttgc ttcaagatct tttttcatat cttcaaatcc tggtttacca
     8461 agtaaagcaa acatattttg tttatacgct tctacaccag gttgattgaa tggatttacg
     8521 cctaattgat aaccactcat agcacatgca agttcgaaga agtacacgac atagccaaat
     8581 gtttcttcat ctaattgtgg aatattaaca acgatattag gtacgccacc atctgtatgt
     8641 gctaataatg taccttcaaa tgcttttgta ttaacttcat caattgtttt accagcaaga
     8701 taatttaatc catctaaatc gtcactatct tcttcaatag taagatcatg ttttggatga
     8761 ttcactttta caactgtttc aaataagaaa cgacgacctt cttgaacgta ttgtcctaat
     8821 gaatgtaaat cagtagtgta gttagcactt gaaggataaa tacctttaaa gtctttacct
     8881 tctgattcac caaataattg tttccaccat tcgttgaaat attgcattga cggttcatag
     8941 ttgataagca tttcagttgt ataacctttg ctatatagaa ggttacggat tgttgcatat
     9001 tgataagcaa tattttcttc taatttgtca gaagataatt ctttacgtgc ttttgctgca
     9061 ccaatcatca tcgcttcaat attaatacct gcagctgcga ttggtaataa acctacagca
     9121 gttaacactg aataacggcc acctacatca tcagggacta caaatgtttc ataaccttca
     9181 tttgtagcta attgttttaa tgcacctttt tgtttatctg ttgtagcaaa gatacgtttt
     9241 ttagcttctt ctttgccata tttattctca actaattgtt tgaataaacg gaatgcaact
     9301 gctggttctg tagttgtacc agatttagaa atgacgttta cagagaaatc tttgtcagct
     9361 aaataatcta ctaattcttt tgtatagctt gatgataaat gattacctac aaaaacaatt
     9421 tcaggatagt cattatttgt tctaaatgaa gatgttagca tttcaatagc agcacgtgca
     9481 ccaaggtatg agccaccaat accaataaca actaacacgt cagaatttgc tttaatacgt
     9541 ttagaagctt ctacaattct tgaaaactct tctttatcat aatcaactgg aaggtctacc
     9601 caacccaaga aattatttcc tgcaccagtt ccttcatgta tcgttttgtg taatgtcttc
     9661 acgatatctt tttgttgttc taattcatgt tctccaaaaa attctaaagt cttaccataa
     9721 tctaattgaa tatgagtcat ctaaaaagcc tccaaatttg taattattag tcttatattt
     9781 acaattccaa ctgtacacta cagtgtaata ttattcatac tgaaaaaata gtcaccccct
     9841 ttagataaga tgacattccc tatatgccaa ttttgtcagt attgatttat tgataattat
     9901 gtcaaaataa aggtataaat taatgaaagg atgaattata gtggaattgc aattagctat
     9961 tgatttatta aataaagaag aagcagcaga acttgcgaaa aaagtagaag aatatgttga
    10021 tattgtagaa attggtacac caattgtgat taacgaaggt ttacctgccg ttcaacattt
    10081 aaatgaaaat ataaacaatg ctaaagtatt agcagactta aaaatcatgg atgcagcaga
    10141 ctatgaagta agccaagctg ttaaattcgg cgctgatgtt gtaacaattt taggtgtagc
    10201 tgaagatgcg tcaattaaag cagcagttga agaagcacat aaaaatgaca aacaattatt
    10261 agtagatatg attgctgttc aagatttaga aaaacgtgcg aaagaattag atgaaatggg
    10321 tgcagactat attgcagtgc acactggtta tgatttacaa gctgaaggac aatctccatt
    10381 agatagctta cgtaaagtta aatcagtaat taaaaattct aaagttgcag ttgctggagg
    10441 tattaaacca gatacaatta aagaaattgt tgcagaagaa cctgacttag taattgttgg
    10501 tggcggtatc gcaaatgctg atgaccctgt agaagcagct aaacaatgtc gtgacgctat
    10561 tgaaggtaaa tagtgatgac aacttttaat cattatcaat taattttaga tgagctaaag
    10621 ggcactttat ctcatgttaa agatgaagaa tttgatggat ttgcatcaga agtaactgaa
    10681 gcatcacgta tatttgttgc aggtaagggg cgttctggat ttgttgcaaa tagttttgca
    10741 atgagactca atcaattagg aaagcaagca tttgtcattg gcgaatcaac aacaccatca
    10801 attcaaaaag atgatttatt tattgtgatt tctggttcag gttcaacaga acatcttcgc
    10861 ttattagcag aaaaagcgaa atcagttgat gcaaaagtgg tattactaac aactaaacta
    10921 gattctgcaa ttggtgaaat tgcagacaca gtagttgaat taccagcagg tacaaaacac
    10981 gatgctactg ggtctgatca accgttaggt agtttgtttg aacaatcatc acaaatcttt
    11041 ttagatagtg tagtcattgg actaatgaca caattagata ttgatgaaac aactatgcaa
    11101 aataatcatg ccaatttaga atagatataa ataagcagtt aatgcggaag attatataat
    11161 cttccgcatt aacaatgtaa attctaatat atagaagaaa gaaggatgaa aattgtatta
    11221 taaaggaaaa gaatttttca cttctaaaga tttagcttta tgtgttatcg gaggaaagtg
    11281 gaagatccct ataatttttc atttacttca agacaaagta ttgagattaa gtgagctaca
    11341 aaaaaagttg ccgcatgtca atcaaaggat gctaataaga caacttagag aattagaaga
    11401 ggaccaaatt attgaaagac atatttattc tgtagttccc ccaaaagtgg agtataagct
    11461 gacatctata ggctacaagc tagataaggt ggtttatgca atatgcgaat ggggtgattt
    11521 attcaaggat gaaataatac attaaaaagt tctggtgcaa attaaaaata aagttaacta
    11581 ctctcttata atgtaaatat tcaattagct gactaacatg tattaatttc gccgttctat
    11641 gaaattaagg gttctgttgc aaagttagaa agatatatct aatcaccatt ttattgtgtc
    11701 agtcttcacc taaccagcta acatataact aatttcgtgg catggtgaaa atccgtagat
    11761 ctgaagagac ctacggctct ttttatataa tccgtaaata cattcaatgc ctttgagtgt
    11821 attttttgcc gtattgacac tttgatatct tgtctttctc accttaatgt gacgatgatc
    11881 ttgttcaatg aggttattga gatatttaga tgtgcaatga cagttaggtt tcagcttaaa
    11941 cactttaatt attttagcca tggctacctt cgttgaaggt gcttgatctg taattatcat
    12001 ttgaggttta ccgaattgtt taataaggcg cttaataaac gcatatgctg attgatgatc
    12061 tcgttttttt gcgtaaccaa atatctaatg tatgtccacc tgcatcaatc gcgcgataca
    12121 gataacacca ctgtccttta attttgatat atgtctcatc aatacgccac ttataatacg
    12181 tttttttatg ttttctcttc caaagttgat ataaaatagg tgcatactct tgaacccatc
    12241 gataaatggt tgaatgatga acatcaaaac cacgttctct taatatttca gatatatcac
    12301 gataacttaa tgcgtatctt aagtagtagc caacggctac agttataaca tctttatcga
    12361 attgtttata tctgaaatag ttcatacaga agactccttt ttgttaaaat tatactataa
    12421 atctaacttt gcaacagaac caaatatcta atgtatgtcc ctctgcatca atggcacgat
    12481 ataaatagct ccattttcct tttattttga tgtacgtctc atcaatacgc catttgtaat
    12541 aagctttttt atgctttttc ttccaaattc gatataaaat tggggcatat tcttgaaccc
    12601 aacggtagac cgttgaatga tgaacgttta caccacgttc ccttaatatt tcagatatat
    12661 cacgataact caatgcatat cttagatagt agccaacggc tacagtgata acatccttgt
    12721 taaattgttt atatctgaaa tagttcatac agaagactcc tgactccttt ttgttaaaat
    12781 tatactataa attcaacttt gcaacagaac cctttatttg aactaatgaa ttgtaaaata
    12841 attttaactt tgtagtttgt gcttattttt cttgttctcc gatatgagtt gaaacttgct
    12901 caagaatact aaaaatatga agatcgtcaa ggctataaat catattttta ccaactcttt
    12961 ttgattttac taatcttgaa gtctttaaag tttttaactg gtgagaaatg gctgattgtt
    13021 ccatacttaa agactgcgca attactccaa cactaagttc ttctttctgt aaaagaaata
    13081 aaattgaaag acgtgtaggg tcactaatca ttttaaatat cttacttacc tcttggatag
    13141 aatcatttgt taacggagaa gttgatgatg atttcataaa acttcctctc tttcatatgt
    13201 gtgttcgttc atgtttaggt tagcacaaga tttttataaa gcaaggtttt tccataagca
    13261 gagctgtttt atagtccaat ttttttatta actaaataag ataactattt ttttgacaaa
    13321 tcagatagag caatatataa tgaacgcata aacatatgaa tgttatttca tatgtaattc
    13381 gtaagcgtta cgatttcaaa aaaatagttt tattaagaag ggtgatagaa atgaaagaga
    13441 ttcaagagca acactcacac gaaaataata gtcacgatca tgaccatgat catgggaaaa
    13501 tgccaattat tttgtacttt attggtttag cactagcatt gatagctttc tttttgagta
    13561 aagagtatca aatcttacaa aatattttgt tcttaatcgc tactataagc gctgggtacc
    13621 atgttattgt ccttgaagga cttggggaga cgatccataa ctcaaaaagt caaaaaagat
    13681 ttatacctaa ttctcatatc ttaatgggat tagcagcaat tggagcatct ttgatgggaa
    13741 attttggaga aggtgcgtta ttaatcttta ttttttctgg ggcacatttt ctagaagatt
    13801 atgcagaagg aagaagtaga cgagaaatta caaaattact cgaaatgaat cccacaactg
    13861 ctcgtttaat tctcccagac ggtagcacaa aaaatgtgaa agttaatgaa ttaaaagttg
    13921 gaaatcacct tcaagtatta aatggtgatc aagtccctat tgatggaatt attttgtctg
    13981 gatctacgtc tattgatgag tcttctatta atggagagag tataccaaaa gaaaagtcca
    14041 agggagacga agtttttggg agcacaataa atggaacggg cacttttaca atggaagtca
    14101 cgaaagaaaa taaagatacg gtgttttcaa aaattttaca attagtgaat caaaaccagg
    14161 ataaccaaac taaagctgca agtattattc aaaaatttga accaaaatat gtaacatttg
    14221 ttttagttgc catattacta tttatattat taactccatt tctacttgat tggacatggt
    14281 cacaaagctt ttatagagga ttggttcttt tagttgcagc ttcgccatgt gctttggcag
    14341 cagctactgt atcggcaact ttatcaacaa cttctaattt agctaaaaaa ggcgttcttt
    14401 ctaaggggag ttcttatcta tctcaattag ctgatattca agctattgca tttgataaga
    14461 cgggaacttt aaccaaagga aaacctgaag tcacgaatca ttattttact gattctatgg
    14521 atgaagaaga aataattgat attgtagtag ctcttgagaa aaattccaat catcctttag
    14581 cggatgctat tttaagaaaa tttgaaccaa aaaaccaact ttctattgaa gtagaaaatc
    14641 agattggaaa aggattgtcc ggagactata atggtcgaaa atatcgtata ggtaaaccaa
    14701 cttcttttga cgacgtctca gatgaatatg ttcgattaaa taatcaatgg gcatctgaag
    14761 ggaaaactgt cgtatatcta gcagtagatg aagaagttat aggccttatt gcacttatgg
    14821 atgtaccaag taaatatgct aaagaaacta ttgagtactt caataaacaa ggtattcata
    14881 ctacgttaat tacaggtgat tcggaaatga caggaaaagc agtcgcaagc aagctaggta
    14941 tagacgaagt gattgccaat gtcatgccag atgaaaaatc taaaattatt gacaaacaaa
    15001 aagaaaaata tggtgtgacc gcaatggtag gagatggtgt aaatgatgct ccagctcttg
    15061 tcaatgcaga tgtaggaata gccatgggag atggaactga tgtggcagta gaggtttctg
    15121 acttagtatt aatgcaaaat aacttaacga aattaacaca gtctcataaa atttctacga
    15181 aaatgaatcg tttaatttgg cagaatatta ttttttcaat ggcagttgta gcttttctaa
    15241 ttatcgtgag cttagtagga ttaacggata tagccattag tgtgatcgtt catgaaggaa
    15301 gtacattagt cgtaatatta aatggtctcc gattattaaa ttctaaatga atacatgaaa
    15361 ttggataaaa tcgtgtatcg agaatcctat acctataggg ttcttttttg gttctgttgc
    15421 aaagttgaat ttatagtata attttaacaa aaaggagtca ggagtcttct gtatgaacta
    15481 tttcagatat aaacaattta acaaggatgt tatcactgta gccgttggct actatctaag
    15541 atatgcattg agttatcgtg atatatctga aatattaagt gaacgtggtg taaacgttca
    15601 tcattcaacg gtctaccgtt gggttcaaga atatgcctca attttgtatc aaatttggaa
    15661 gaaaaagcat aaaaaagctt attacaaatg gcgtattgat gagacgtaca tcaaaataaa
    15721 aggaaaatgg agctatttat atcgtgccat tgatgcagag ggacatacat tagatatttg
    15781 gttgcgtaag caacgagata atcattcagc atatgcgttt atcaaacgtc tcattaaaca
    15841 atttggtaaa cctcaaaagg taattacaga tcaggcacct tcaacgaagg tagcaatggc
    15901 taaagtaatt aaagctttta aacttaaacc tgactgtcat tgtacatcga aatatctgaa
    15961 taacctcatt gagcaagatc accgtcatat taaagtaaga aagacaaggt atcaaagtat
    16021 caatacagca aagaatactt taaaaggtat tgaatgtatt tacgctctat ataaaaagaa
    16081 ccgcaggtct cttcagatct acggattttc gccatgccac gaaattagca tcatgctagc
    16141 aagttaagcg aacactgaca tgataaatta gtggttagct atattttttt actttgcaac
    16201 agaacctaga aactcccaca taacaaattt ttcacgcttg ctattactcg aattaccttg
    16261 tgcttgcctt agtgcatgac tacctttagc agtaattgaa tatagtgaaa aaccagtgat
    16321 ttttctgttc ttttccagca aagaattata ttgtattgat ttttggctaa caaagccaac
    16381 tttctttaac cagccacaaa tcattctcgc atatttatct gctgtgcctt ctacatctga
    16441 tcttattttt aattcttctt ttttattttc agactcttta atccagtcta acataagttc
    16501 ttcagagtat gaggtgaaac caggctcgtc tttaaaacct aaacgattac ctataaaaaa
    16561 ctttgttact tctgtattat tatttaatat ttctaagact cttgtagcag gaggataact
    16621 taagaatgcc tctcttaaaa ccttattcat ctctacttcg ttttgagttt caataaattg
    16681 ttttcctctt gaagtaattt taaatatatc tgtctggcga ttttgctcta cgaaattcaa
    16741 actaactgcc catcttaaaa aaccatctga agaccattca tcggtaaaat gtttgttttt
    16801 tgttgaagcg ctttgtgaat ctaaagaaat ttgtattaat gcgttaggta gtgagtactt
    16861 tctagatttc ggagtttttc tatctttacc aagatttttt cctaccaatt ctatatatga
    16921 aaactcttcg atgccatcat tcaatttttc ttgcaatgac gattgaatat ctttgaaatt
    16981 atgaagtttc tctttaatta gactctcttt cagcaattgg tattgtttcg aatttttact
    17041 aaatatttct actgtttgtt ttagtttttt aaaatcagat ggattttgca cccaaccaaa
    17101 agatcttata gtcatatatc tccctcctgt ctatctcact ttgattttac agttatttgt
    17161 ttgaacacac aattatatag taaagaagaa tactgtaata aaacagttac gctatatcta
    17221 attaagtagt gttacatttt ctcctccaat aagatattat ttccattctt ttattcttgt
    17281 tttatatacc gatagatata aattttggat tttaaaagta tcctcctaga gagtgctaag
    17341 ataagatatt ttgagtttaa attaacataa attatgatta tcagaagttt catcactata
    17401 aaaggtgtat caaagattta tactcccttg atacaccttt tacattcatt tttaattacc
    17461 gaagaatcga ctccaaaatc cctttttagg tggttctacc tccctattat catcaggatc
    17521 actcttcgtt tcttcaacga acttatcctc ttttgttaat tcaccttcat ctgtactgtc
    17581 attctttttc tcttcggcta tatccttgta atttacttct gttggttgac gctttgtttg
    17641 ttgttggttg atattttgcg attcttcagt aaaagttgct tcttgcggat taatattttg
    17701 tctattattc gtcgctgtat caaaagaata attaagctgt ctttcttctt ctaattgact
    17761 ttctagtttt tgaatttttt tattgctttc taaagctaat atttgttgat tctccaacaa
    17821 tttatttaat gtattaacat tgctattttg ttgatctaat tgcttagtta aattctcaat
    17881 atatttttca tcatttttag ctctagtttc aaagatttct atttgctttt ctaattcgtt
    17941 tacttttgtt tttaatgtct cagaactatt tgaattatta tatatattct tttctgcttt
    18001 tgcagtattt tcaccaaaca attctttttt tactgattct ttattttgga ttgtactctc
    18061 tttcttagta attttttcta taattttcaa ataatcatta tcatcaatat aattaatccc
    18121 attttctttt tcaaaagtta tatttaaact tttagcatta ttaacaatag tttgtttagt
    18181 tacacctaat tcatcagcaa ccattttaat agttctcata acatccaccc ttaggtacct
    18241 aatttagtac ctaaatttta ccacctaatg cagtttattt catcaattac cactaaattt
    18301 actacctatt tactacatat gcacctaatt aactacctat aatatgtttt tgaagcttaa
    18361 ttaggtacta aaacaatgaa ctacacattt tgccatggca atgtgctttt aactacattt
    18421 aaaactcttt atatactttc ttaaaagtgt taatattgct ttataaatac taaaagagtc
    18481 aatgctattg gcgtagcatt gactctcggt aataaaacga ttcgcactcg tttgtttata
    18541 tattttttga tacttgtatt atatctatct aatcatctaa gtgcaagcac aaaacatata
    18601 acttacgtaa aaattgtttt attacctcaa tcctaaaaat ggaaatgagg tttttatt
//
