LOCUS       CP127635               20728 bp    DNA     circular BCT 19-JUN-2023
DEFINITION  Staphylococcus aureus strain C246 plasmid pC246_1, complete
            sequence.
ACCESSION   CP127635
VERSION     CP127635.1
DBLINK      BioProject: PRJNA914892
            BioSample: SAMN32360914
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 20728)
  AUTHORS   Bouras,G., Houtak,G., Nepal,R., Shaghayegh,G. and Vreugde,S.
  TITLE     Hybrid Oxford Nanopore Technologies Illumina Sequences of 174
            Staphylococcus Aureus Isolates from Chronic Rhinosinusitis Patients
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 20728)
  AUTHORS   Bouras,G., Houtak,G., Nepal,R., Shaghayegh,G. and Vreugde,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-JUN-2023) Department of ENT Surgery at the Basil
            Hetzel Institute, Adelaide Medical School, The University of
            Adelaide, 37 Woodville Road, Woodville South, SA 5011, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 14-NOV-2022
            Assembly Method :: Flye for Genome, plassembler (Unicycler) for
            plasmids v. 2.9.1 (Flye) with short read polishing, 0.1.1
            (plassembler) with 0.5.0 (Unicycler)
            Assembly Name                     :: C246
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 70x
            Sequencing Technology :: Oxford Nanopore MiniION and Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 06/11/2023 01:36:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.5
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,775
            CDSs (total)                      :: 2,693
            Genes (coding)                    :: 2,622
            CDSs (with protein)               :: 2,622
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 43 of 71
            Pseudo Genes (incomplete)         :: 26 of 71
            Pseudo Genes (internal stop)      :: 10 of 71
            Pseudo Genes (multiple problems)  :: 7 of 71
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..20728
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="C246"
                     /isolation_source="Patient Sinus Swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pC246_1"
                     /geo_loc_name="Australia: Adelaide"
                     /lat_lon="34.9285 S 138.6007 E"
                     /collection_date="2014-07-07"
                     /collected_by="ENT Surgery Department at the Queen
                     Elizabeth Hospital, Adelaide, Australia 115"
     gene            166..842
                     /locus_tag="PCM24_13755"
                     /pseudo=""
     CDS             166..842
                     /locus_tag="PCM24_13755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /name="replication initiator protein A"
     gene            853..1135
                     /locus_tag="PCM24_13760"
                     /pseudo=""
     CDS             853..1135
                     /locus_tag="PCM24_13760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199895.1"
                     /note="frameshifted; internal stop; incomplete; partial on
                     complete genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology. GO_function: GO:0003677 - DNA binding
                     [Evidence IEA]; GO_process: GO:0006260 - DNA replication
                     [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            2345..2962
                     /gene="cadD"
                     /locus_tag="PCM24_13765"
     ARG             2346..2959
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="99.51"
                     /coverage="100.0"
     gene            2981..3328
                     /locus_tag="PCM24_13770"
     CDS             2981..3328
                     /locus_tag="PCM24_13770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]; GO_process: GO:0006355 - regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WJA61352.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNQEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            3497..3589
                     /locus_tag="PCM24_13775"
     CDS             3497..3589
                     /locus_tag="PCM24_13775"
                     /inference="COORDINATES: protein motif:HMM:NF033608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WJA61353.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            3801..4775
                     /locus_tag="PCM24_13780"
     CDS             3801..4775
                     /locus_tag="PCM24_13780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4062 domain-containing protein"
                     /protein_id="WJA61354.1"
                     /translation="MSNTKIKYQIFISSTYLDLIEERQAVVEAVLNSNNIPAGMELFNS
                     SSKSQWEIITQWINESDAVILLLGSSYGTIDSEENISYTEMEYNFAKSLGKPIYVFEMN
                     KASTESAEKSKKLDEFKTKVKENRLISPNINDISELKSKVSQTLMQSVPSEIKENSGWI
                     RVQDCGKNVKKLKKLDAIQRDLDTYDFLKEELYKIFMYVKTFYFQHTPFDDSYIEDIEN
                     YLLNYENNPHKSFMKIKVYDYKNFLKHLKNILILIKQGKKPLAQAGHFKLSFYEEDLKL
                     LQKNYKTTLVDIKGLNKHFYKECDRCLKAYNIFIEGINKHLYE"
                     /name="DUF4062 domain-containing protein"
     gene            complement(4895..5710)
                     /locus_tag="PCM24_13785"
     CDS             complement(4895..5710)
                     /locus_tag="PCM24_13785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019467708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WJA61355.1"
                     /translation="MTKNQNFIETKEYKRFAEFCDACIKYQYIGICYGQPGVGKTLSSR
                     YYTNWDTIEKQVNHRGWEDLASKTTDDILSVDKIFYNAPAEKQTKLRNDLYSITAIIDL
                     GQKLHVVNKYGHEHSKHYSDMFKYIDLIIVDEIDRLKVQHLEQLRAIYDEHNLAMIFIG
                     MPGIEKKLSRYPQLYSRIGFAHEFDNLSKDETHHILEYKWQDLGFDLKLEDFTDYEAIT
                     TIIKITKGNFRLIHRLFAQIDRIMDINGLDKISTEVVETARDSLVIGIR"
                     /name="AAA family ATPase"
     gene            complement(5703..7145)
                     /locus_tag="PCM24_13790"
                     /pseudo=""
     CDS             complement(5703..7145)
                     /locus_tag="PCM24_13790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790716.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_process: GO:0015074 - DNA integration [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DDE-type integrase/transposase/recombinase"
                     /name="DDE-type integrase/transposase/recombinase"
     gene            complement(7117..7710)
                     /locus_tag="PCM24_13795"
     CDS             complement(7117..7710)
                     /locus_tag="PCM24_13795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WJA61356.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNQKDLNLLKTLYDNGTPI
                     KTIAEQWHVSRTTIYRYLNKLEDKEDEKQGEVSN"
                     /name="recombinase family protein"
     gene            complement(7974..8354)
                     /gene="blaI"
                     /locus_tag="PCM24_13800"
     ARG             complement(7978..8354)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            complement(8344..10101)
                     /gene="blaR1"
                     /locus_tag="PCM24_13805"
     ARG             complement(8348..10101)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.56"
                     /coverage="100.0"
     gene            10208..11053
                     /gene="blaZ"
                     /locus_tag="PCM24_13810"
     ARG             10209..11050
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            11422..12030
                     /locus_tag="PCM24_13815"
     CDS             11422..12030
                     /locus_tag="PCM24_13815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002436987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WJA61360.1"
                     /translation="MIVGYARVSSNDQNLERQLENLKTFCAEKIFTEKQSGKSIENRPV
                     LQEALNFLRMGDRFVVESIDCLGRNYDEVIHTVNYLKDKEVQLMITSLPMMNEVVGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRI
                     IYHRVVEMLEEGQSISKIAKEVNITRQTIYRIKNDNDLI"
                     /name="recombinase family protein"
     gene            12444..12737
                     /locus_tag="PCM24_13820"
     CDS             12444..12737
                     /locus_tag="PCM24_13820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WJA61341.1"
                     /translation="MKKKFVSSCIASTILFGTLLGVTYKAEAATVHVAGGVWSHGIGKH
                     YVWSYYSHNKRNHGSTAVGKYSSFSGVARPGVQSKASAPKAWGGNKTFYSLH"
                     /name="lactococcin 972 family bacteriocin"
     gene            12812..14746
                     /locus_tag="PCM24_13825"
     CDS             12812..14746
                     /locus_tag="PCM24_13825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001670421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="WJA61342.1"
                     /translation="MKKFKLFLDFSTLLLISGLLFLFFFKENEEIIPESSNILTISNWD
                     KSNSKSKVLDVIESGAKNQNIQIIKSVKDFDNKKEFFVFNSKRNNSDFIRNKTSLLTPS
                     DLLNREIKGKYYIIGEHFNVEELTSELKKAGLTSEVEYINRNILFFELVIDNDLLVPFI
                     FLGVLYLLYFLYDRGYNLKFYAIQKLHGFSTTRIIFHNIHIKIIYWLVLTAIFFIANIL
                     IIHIANLELDFLMFIRRFIVLLFVFACITTLLWLISYSLLLKLSIPLILKGKKGYKFSI
                     FMGTFTKCIMVLILSFLLAQNLNAYTKLKNIYDSEKIWQKLDNYYTLEISPNIRNSEEK
                     QILETNIYNLIKKSEQLGGLLLKNNNIANPDKNNYIPENGNVFFINNNFLNFYKNINHD
                     FKMIDNHSDKINVFIPPRLQYQKSEIQKNHQGWIDFQKQQNKKVDVQVLSKNVSVFSFD
                     RTTNLKFGYLDSPIVMLLTLDDLTGDFYLAAVSQGGYLFKDLDTLKQLLKDNHLEEEIS
                     GITNYKDSVLNELNETKTKMIITIVTIIINVFILLIATVFETIQYFSWNKKQLLLRKIH
                     GYSLFSSNVRYLTISILLSIMLAYTTHILFGSKILLFIIMSIAIIQHLLQIAYIKYLEK
                     YFKDLMREI"
                     /name="bacteriocin-associated integral membrane family
                     protein"
     gene            14750..15061
                     /locus_tag="PCM24_13830"
     CDS             14750..15061
                     /locus_tag="PCM24_13830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YxeA family protein"
                     /protein_id="WJA61343.1"
                     /translation="MKRTLIIVTIVLLIIILSLLLVRNEHLDRFNPLLKEKVSYAKVPK
                     DTQDYRNITVYSKNGEKKSYKLDFLGYDPTKEYVKVNHKGKYVRSIEYITKDIPSFLK"
                     /name="YxeA family protein"
     gene            15073..15699
                     /locus_tag="PCM24_13835"
     CDS             15073..15699
                     /locus_tag="PCM24_13835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WJA61344.1"
                     /translation="MIKLENVFVKKGNKNILDGCNFNFEKGKSYALVGESGAGKSTLLN
                     IIAGFEDVSQGSIYIEDKLLKKKVDFYRYTLGYLFQNFALLENQTISQNLDLALKFKKN
                     KKDNMNLKKEVLKKVGLDLDIKRIVSSLSGGEQQRVALARLILKDPKIILADEPTGSLD
                     TKNGKIVIDLLLKLLDENKTMIVVTHDLELAKRFDVIVNISELRS"
                     /name="ABC transporter ATP-binding protein"
     gene            15937..16566
                     /gene="mobV"
                     /locus_tag="PCM24_13840"
                     /pseudo=""
     CDS             15937..16566
                     /gene="mobV"
                     /locus_tag="PCM24_13840"
                     /inference="COORDINATES: protein motif:HMM:NF013258.2"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MobV family relaxase"
                     /name="mobV"
     gene            16660..17205
                     /locus_tag="PCM24_13845"
     CDS             16660..17205
                     /locus_tag="PCM24_13845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001805533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase"
                     /protein_id="WJA61345.1"
                     /translation="MYEIKTKNVGGWFHKEKQETGNIVITKTDFEKYTKQIKAAQMILD
                     DYECIKSGKSLKKAEKQNESLVNELTSVHMENEKLVEEFNDLAQRYNYLLSENEKKDKE
                     LNYTLKLFNQVFKIIKSMMKEERYHTLINHIDNHLDNSKIREVMTIDNNDEQFFKKKYQ
                     AQEREIIFKEDREDGYTL"
                     /name="recombinase"
     gene            complement(17247..17531)
                     /locus_tag="PCM24_13850"
     CDS             complement(17247..17531)
                     /locus_tag="PCM24_13850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001793642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WJA61346.1"
                     /translation="MKTFIHNKLLYYQCQTIKGVQLFKTLLLCGKNTPFMWQKHSFYVA
                     KTLLLCGKNTPLGIEIPCCSRAEKAPKKVFKKIYKNILKSSRGATYFSS"
                     /name="hypothetical protein"
     gene            17589..18449
                     /locus_tag="PCM24_13855"
     CDS             17589..18449
                     /locus_tag="PCM24_13855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WJA61347.1"
                     /translation="MTGETVVYKNEMNLVPLRRFTATEINLFFAMCNKLKEQDTNTLRL
                     SFDELKKLSNYSPETRNINRFANDLDNVYKKMLNLTIRYEDDDVIERFVLFNHYRIHKR
                     EQYLEISTSSNLKHILNSITNNFTKFELKEMTRLKSTYSKNMFRLLKQYKHTGYLKIHI
                     DDFKNRLDIPKSYRMTDINKNVFKPIIIELGSIFNNLTINKIKAKKGRKIEWIEFTFDA
                     EKRIHNKRQPQMSKIDKSRQYVRREKTPKWLEERSYEKQPQKDYDPQLEKEREDFLKQL
                     ELNWE"
                     /name="replication initiation protein"
     gene            18536..18877
                     /locus_tag="PCM24_13860"
     CDS             18536..18877
                     /locus_tag="PCM24_13860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WJA61348.1"
                     /translation="MKLAEAIKEQRELKGWSQEELANILKVSRQSVSKWESAKNYPSLD
                     ILIAMSDLFGISLEHLIKGDARFKKVILEGNYRESNRVPSIVDFLYDFWWLFFPVAGFL
                     VWAIHSFMG"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(19116..19187)
                     /locus_tag="PCM24_13865"
     CDS             complement(19116..19187)
                     /locus_tag="PCM24_13865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WJA61361.1"
                     /translation="MNEILVHIMTTAISGCLVTLFGY"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            19336..19521
                     /locus_tag="PCM24_13870"
     CDS             19336..19521
                     /locus_tag="PCM24_13870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WJA61349.1"
                     /translation="MFGDQRQEATKYVIKEGYQDIYFLNKNGEWYYFEVRSVWRGKHII
                     RVKDGLLGWRKEIVTE"
                     /name="hypothetical protein"
     gene            complement(19740..20483)
                     /locus_tag="PCM24_13875"
     CDS             complement(19740..20483)
                     /locus_tag="PCM24_13875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WJA61350.1"
                     /translation="MKSVKRLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESATEDKQKKESDNINFESKSDAQIVEILKNQINTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNAR
                     QNVDAQEKTYTTSPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAQREDVSANPND
                     NDSDIEEKSEETEPKKGFWSRLFGN"
                     /name="DUF536 domain-containing protein"
     ARG             10209..11053
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     BGC             7444..17737
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          1193..1340
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="81.333"
                     /coverage="100.0"
                     /evalue="2.96e-25"
     Typing          17590..18449
                     /name="rep_cluster_2214"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(19741..20483)
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          15938..16212
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="94.565"
                     /coverage="100.0"
                     /evalue="4.71e-46"
ORIGIN
        1 ttggtaataa aacgtttaga aactgtttat ttatataatt ttcgatactt agattatata
       61 atgaataata tcttagtgca agcacctaga ttattaaata aacacaaaaa atgtaagcgt
      121 tttattacct cttaccaaac taaaattcgg aaagaggttt ttattatgtc aattaaactt
      181 tacaacataa atgaggaata cagagaaaag ttttatcaaa taccgaaagt attttttaca
      241 aatcctaaat atatcaagtt atccaatgat gcaaaaatgg catggggtat tcttagagat
      301 cgtttagatt tatcaattaa aaatggttgg gttgattcta aaacaggtaa tatttatttt
      361 tattacaaaa atgaaaaccc acaaaatata ttaaattgta aaaaagataa agtaattaaa
      421 ataaagaaag aacttaattg aagccgaatt actactacaa gaaagacaag gtttaaataa
      481 gacaaataaa ctttatttag ttaaaccaga agtaacagaa gatgatattt ataaaattca
      541 aaagcaagaa aacactgttg agagcagcaa tggcaaggaa gtcggaaaaa ccgacttcaa
      601 gaagtcgata aaacagaatc taatgatact gaacttagct atactgaatc taacaatact
      661 gaaataaatg atatgaatga cttgaatgat atagagtccg aaaatgaaat tagtaatcat
      721 tcaagtcaat gcaaggttat ttaatgcaaa caattttaac tgaatttgaa gaaacacatg
      781 cactttatat gcgccgtaaa aacatgaaac aatataatat ctttaatcaa tcattcaaat
      841 gattttataa caatcaaaga tacatcaaaa tatttcgtta aatcatctga ctttttaact
      901 gatagcgatg aaaaaatcaa gaaattgtca gtgatctaga aaaagatttg tatcgaaaac
      961 gtatgttaag ttatggtgga ttgcttaaat aaaaacataa aattttaaac ttagacgatg
     1021 ctgaagatgg caatttaatt aatacaagtg atgaagataa aatagcaaat gaagaagaaa
     1081 aggcacattc gattacggca attttgaaaa gcaaaattat tatttaaggc attagtgata
     1141 actgatgtct ttttttatta cttttttgta aaaaaagtgc tgtcttattt ttgtgacaaa
     1201 tgctgtatgt agtgtcacaa aagtgtgaca cttgagcttt ttatgacccc acacaaaaac
     1261 attttcgaag ccttgaaata tctggctttg ccagatcccc cattcattga tggggacaaa
     1321 tttcccttat gctcttacgg agattttaga gttaaattaa aatttctaag tttttgataa
     1381 gaaaagccct gcaggaattt agaagaacgt ggggaagttt taaagaattt tatgctaatt
     1441 tttaatttgc atgtaaatgg gcagtgtcta aaaaatagtt attgtttttg ctcaaatttt
     1501 tgtttttgaa aatagcatat atttatttgg ctcatatttg cgttttaaaa gcgtatataa
     1561 gttttagata taaaactata tgaatcaccc ctaaatcttt aaaatgccct cttaaaattc
     1621 aaaataaggg cataaaaaat aaaagccccc ccagataaag tgaggtagct ttttctttcg
     1681 acgccgtatc gtcgatgtaa ttcaaaaaag ttatgggcta taaatctaca tcactttttc
     1741 aagaatgtag tagcaatatt caacgcaaat taatttttat aactgctcgg aatatctcaa
     1801 gccgtttctt taattttgaa ataaaaaaaa atcgacgaag gtcgattacg tttttgcaca
     1861 tgtcgattta tccgacgtat aagtgcgccc ttacgggatt taactagatt ataacgacga
     1921 attttagacc tgtaaagcaa taacaattag gtctaccagg tagataaagt gtacaaagta
     1981 gaaccgaaaa agttatttat tttgaagatt tttcgtagat ataatttgct aataaacttc
     2041 ctaaaactga ataaagaaaa atagttaaac tcatgtaatc actccataat tctgaagtgt
     2101 ctccatgtct acgcatagac acgcatttat gccgagaaaa tttattgtgc gttgagaaga
     2161 acccttaact aaacttgcag acgaatgtcg gcatagcgtg agctattaag ccgaccattc
     2221 gacaagtttt gggattgtta agggttcttc tcaacgtcaa taaagcaatt ggaataaagc
     2281 acctatgatt atttaaaaat ataagttata atacattcaa aaatattttt gaatgaggtg
     2341 tattatgatt caaacggttg ttgctgctgc tgttctttat attgctacag cagttgattt
     2401 attagtaatt ttattaatat tttttgctag agcaaagact agaaaagaat atagaaatat
     2461 ttatgttggt caatatttag ggtctattat tttaatatta gttagtttgt ttttagcttt
     2521 tgtattaaat tatgttccag aaaagtggat attaggttta ttgggtttaa taccaattta
     2581 tcttggaatt aaagtggcta tttatgatga ttgtgaagga gaaaagagag ctaaaaaaga
     2641 attgaatgaa aaaggattgt ctaaattagt tggtacggtt gcaattgtta cgatagcaag
     2701 ttgtggcgcc gataatattg gtttatttgt tccgtatttt gtgacattaa gtgttactaa
     2761 tttattactt actctgtttg tctttttaat tttaattttc ttcttggtgt ttactgcaca
     2821 aaaattagct aatatcccag gaattggaga aattgttgag aaatttagtc gttggattat
     2881 ggctatcatt tatatagctt taggtttatt tattattatt gaaaatgaca ctattcaaac
     2941 aattttagga tttatatttt aatttagggt gtgattttat atgagttatg aaaatacttg
     3001 tgatgtgatc tgtgtacatg aggataaagt taacaatgct ttaagttttt tagaagatga
     3061 taaatctaag aaattactta acattttaga aaaaatttgt gatgagaaga aattgaaaat
     3121 catattatct ttgattaaag aagatgagtt gtgtgtttgt gatatttctt tgatattgaa
     3181 aatgagtgtt gcttcaactt cacatcattt aaggctttta tataaaaatg aggtacttga
     3241 tttttataaa gatggaaaga tggcatatta ttttattaaa gacgatgaaa taagagagtt
     3301 tttctctaaa aatcaggagg gtttttgaaa cgagtgaaac gagtttcttc ttgtcttgat
     3361 actataaaaa acaaagttat ataacataag acgacttatc ggaagttatc tatcatcgta
     3421 tattcggaga tgatataata tacaggtcgc ctatctctca ggcgtcaatt cagacgcaga
     3481 gaggaggtgc attactttgc taatcatttt cgttcacatc atagcaccag tcatcagtgg
     3541 ctgtgctgtt gcgtattata cttattggct tagtaaacgc aacaaataat taataggcga
     3601 ctttataagc cagcatcgaa aaaatcccca cactattgca gtagtgtggg gattggtgca
     3661 ttaattgtta atcattttcg ttatctagat tataacactg gttagtagag gaatgcaaaa
     3721 agataatatt ttaagtagtc tttttggata ttatcatatg atatatttat gtaaattgat
     3781 tttttattaa aggagcatat atgagtaata ctaaaattaa atatcaaatt tttatttcat
     3841 caacttattt agatttaata gaagagcgtc aagcagtagt agaagcagtt ttaaacagta
     3901 ataatattcc agcaggtatg gaacttttta actcaagtag taaaagccaa tgggaaataa
     3961 taacacaatg gatcaatgaa tcagatgcag tgatattatt gttaggttct agttatggaa
     4021 caattgatag tgaagaaaat attagctata cagaaatgga gtacaatttt gctaaatctt
     4081 taggtaaacc tatatatgtt tttgagatga ataaagcatc taccgaatcc gcggaaaagt
     4141 ctaaaaaatt agatgagttt aagacaaaag ttaaagaaaa tagactaatt agtccaaata
     4201 ttaatgatat ttcggaatta aaaagtaaag tatctcagac tttaatgcaa agtgtaccta
     4261 gtgaaattaa agaaaatagt ggatggataa gagtacagga ttgtggtaaa aatgtaaaaa
     4321 aattaaaaaa attggatgct atacaaagag atttagatac atatgatttt ttgaaagaag
     4381 aactttataa aatattcatg tatgtaaaaa ctttttattt ccagcacaca ccatttgatg
     4441 atagttatat tgaagatata gaaaactacc tgctaaatta tgaaaataat ccacataaat
     4501 cattcatgaa aataaaagtt tatgattata aaaacttttt aaaacattta aaaaacatat
     4561 tgattttaat taaacaagga aaaaagccat tagctcaagc cggtcatttt aaattaagct
     4621 tttacgaaga ggatttaaaa ttgttacaaa aaaattataa gactacgcta gtcgatatta
     4681 aaggattgaa taaacatttt tataaggaat gtgataggtg cttaaaagca tataatattt
     4741 ttattgaggg tataaataaa catttatatg aatgatataa gtacacccta atcatacata
     4801 tataattgtt gtcactttac tcgatatatg agaatgactt tacctaataa atgagaaaag
     4861 caacgcacta tattaaaatg cgttgctttt tctattatcg aatacctata actaaactat
     4921 ctctagctgt ttctacaact tctgtactta ttttatctaa accatttata tccataattc
     4981 tgtctatctg cgcaaataaa cgatgaatca gcctaaaatt cccttttgta attttaataa
     5041 tcgtcgttat tgcctcataa tcagtaaagt cttcgagttt taaatcaaat cctaagtctt
     5101 gccacttata ttctaatata tgatgcgtct catctttact tagattatca aattcatgcg
     5161 caaaacctat acgcgaatat agttgaggat aacgagatag ttttttctct atacccggca
     5221 taccaataaa tatcattgct aaattatgtt catcataaat agctcttaat tgctctaaat
     5281 gttgcacttt aaggcgatca atctcatcta ctataattaa atcaatatat ttaaacatat
     5341 cactataatg tttactatgt tcatgtccat acttatttac aacatgtaat ttttgaccca
     5401 aatcaatgat tgcagtaata ctatataaat cattccttaa tttagtttgt ttttctgctg
     5461 gtgcattata aaatatttta tccaccgata gtatgtcatc ggtcgtttta ctagctaaat
     5521 cttcccaacc tctatggtta acttgttttt caatagtatc ccaatttgtg taatacctag
     5581 acgataaagt ttttccgaca ccaggttgac cataacatat accaatatac tgatatttaa
     5641 tacaagcatc acaaaattca gcaaagcgtt tatactcttt cgtttcaatg aaattttgat
     5701 ttttagtcat tacgatatct ctttaatttt ttgacgtttt tagtcgtttc ttgaggtgaa
     5761 taaccacatt tttttcttcc ttaattaatt ccgtggtact tggactagca atattttgtt
     5821 ttaagtgttt tcttctctga ctacgagcgt gctgtatgtc ttttatatct atggagtaat
     5881 cagctatttc tggacatata gcagtacaaa gaaattcatc tctataaaac acacgtattt
     5941 cagccatatc atttgggtta taacgaatca gtacatattc acctacataa gcttctagat
     6001 tagtattact gtatcgaaaa ccttgaaaat gaatgccatc tgaatgaact tttctagatt
     6061 taggtatttc caacaataat aaatcaagtt gttctaagct acttggcata ttagggaaaa
     6121 agtgattact attccaatga ctgataggcg tggtatgaat agtactatgt tctttttgat
     6181 tataatcttc aattaaaaag taacgtaatt tttcttcaaa attgtgaaaa tttattagat
     6241 tactaggagt atcattattg tttatatatc caggcagttg ttctaagaaa gtttgattaa
     6301 ctgtctgaaa gaatcgttct atttttccac gaccacgagg aacaccaact ttcgaaaaca
     6361 tcaagttaat tttcaaatca atagcgactt gttccatatg atgtgaagta aagtcacttc
     6421 catgatctgt gtagaatttt tcgggtatac cacacactgg ccaattggta tcatttttat
     6481 tccatattgc ttggtgtagt gttaatgctg tgttttgagc attggggggc atcaaaactt
     6541 aagaaatagc ctgcaattgc acgactatag tcatccataa taatagttag ccatggtcta
     6601 ttgatattac ctttttggtc taatataaag atatctagca aagtatggtc tgcttgccat
     6661 atttcattgg gtctcgagga ttctctaatt tgtattaaat cgtacttatt ttgatagtat
     6721 ttttcaccct gatgagagaa atcaataaca gacttaggca tcgctttaat aacactataa
     6781 atttgtttat aacttggtat atcaaaatta ttttctttac agtaattagt gattttccta
     6841 tgaattgtgg ctatactatt tcttttattc ataagcgcaa ggcgttcaat ttcatcaatt
     6901 atctttggtt ctattttacg tgttccttta tcagctcttg tcgcatagat tagtccttta
     6961 agtccttgtt ctttatatga cttattccac ctataaaggg tgcttaacgc aatcccttta
     7021 cttttagaaa tacttgataa agattgttcg cctaggataa aaggttttat aatattgtac
     7081 ttttgagtag cttttttacg tttggcttca gaaaaattag ttagatactt ctccttgttt
     7141 ttcatcttcc ttgtcctcca atttattgag gtaacgataa attgttgtac gtgaaacatg
     7201 ccactgttct gcaattgtct taattggcgt gccattatca taaagggtct taagtaagtt
     7261 taaatctttt tgatttaatt tttctggtct gcctccatat cggcctctag cacgtgctgc
     7321 aattcggcca gctgaagaac gctctaaaat taaattacgt tcaaattctg caaatgctgc
     7381 gaataaatga aataataatt gtccagttga acttgattta tccattgtta tattttcttc
     7441 taaactatgg aaacttacac ctcgttcgtt aagctcatta actaatgtga ttaaatcctc
     7501 catattacgt cccaatctat ctaatctcca aacaacaatc gtatctcctg acctcgcaaa
     7561 ttcaattgct ttatctaaac caggtctttt actttttgaa ccactcatat ggtcattaaa
     7621 tatcttttca caaccatatg tatttaatcg atcctcctgt aaatttaaat tttgtaatcc
     7681 agttgaaact cttgcataac ctattttcaa aatacaaacc tcctatatac atcttcaatg
     7741 taccataact taattacaag gtcttttatg aacatagatt ttttgttggg tttttgaaca
     7801 cataatccta tgtaattctt acttatttag acataaaaga agagtgtaca gaaaatggtt
     7861 attttctgta cactctcatc tttaataata tattttaaat gtcattaaca aaactaattt
     7921 aataagagtc aagcatagtt tacatatgta ttatgtttga aacatacctc taattacttt
     7981 ttactaatat catttaaaat atctcgcaat tcttcaattt ctttgttatt taattcttca
     8041 tttttcgcaa aattcaacac taaacttttc atatcccctc catacagttt attaagaaag
     8101 gttttagcag ttttcatttt aatatcgtct tctttaatat ttgatgagta aaaataaata
     8161 ttttctgatt tgtatcgttt tataatctct tttttatata gtcttgtgat taatgttcta
     8221 atcgttttat cactaacttc tttatatttt tgaatttcaa ctacaatttc attagctgat
     8281 actgattttt tatcccatat tatattcata acatcccatt cagccataga tatttcaact
     8341 tgcttattgg ccatttaaaa cacccattcc ttttaatatt ttttcactta ttaattcagc
     8401 atttttccca gacgggtttc catctgataa atgtgtagca aaataatact tatcatgatt
     8461 tgtaattacg taacctacaa accacccatt attatacttc ccgtttacta tacctgtacc
     8521 tgttttccca tacagttcat acttttcatt tttcttaatc aataatgaag aagataattg
     8581 attctttgct tttttactaa aatggttatt ttgttccatc atatttttaa aaactattac
     8641 ttgttcaaga ttagatattt tcaaactatc ttccatccaa tagcttttat aacttcccaa
     8701 attttcatta ccataattta attgcttgag ttgagccgca gtatagttct ttggtatttg
     8761 attactaata cgttcgaagt accaattaac tgaattttgc attgctgtat ttaaatcttg
     8821 ttccttattc caagactcga aaagataatg tttatgattc catgacatac gtgaattttt
     8881 atcacttata atatgacggt caagtccaaa cagtgctaaa taaattttgt aagttgaatc
     8941 aggagaatat ctttttctac tttctttttc attataaata tagtatttgt ctttcttcat
     9001 gctgtacata acgaaagatc cactatttga accaaaattt ttactttcat ctaaaatttg
     9061 gtaatcgctt tgtaagggct ttttataatt ataatcagtt aaggattgcc ccattaaaaa
     9121 ctggctttga attatcatga taaaaaaagt aaaaatacaa ataaaaatta gaattaattt
     9181 tgactgcttt ttcagatcgg cttcttttat attaattaat ctatttttga gtaatgattt
     9241 tttaccatta aatgaatggc ttaatatatt tttgttgaaa aatgaggttt ttaatacgga
     9301 gtccataata gattccgcat aagttttaaa ttcatttttg ttaatattat taaggacaaa
     9361 tctatcggct tctacttcat tgtcatgaat tatctttctt tttacaatat gtactaatgg
     9421 attgtaactc ataataatag agaagatatt aaagataatt aaatgtaaag tatctctatt
     9481 tttagcatga gcatattcat gcagtattat atattttagt cttttatcaa ttacactttt
     9541 aaaatatgaa ctaggaatca aaataatata tttcccatac caaaaagtta ttggagattg
     9601 aatagcctct gcttttcgaa tcacaatatt ttttttatat tgatggttga aaagtatcgt
     9661 atctatttta tttttttcat tttcgtttag ataaagtgac tgtttcttta aatatttaag
     9721 atataataag gctttcaaaa atttaaaact taaaataata actaaaacta tccaaataac
     9781 tgtgcagata ttatcaattg aatcccaatt aaacttatgg atatctgttg cgaactcttg
     9841 aacaggtttg gtggtaatta tgttatggtt caagtcgtgt gacttacttt caactgtggg
     9901 cgcttgatta ttcacattat taaattttat aaaagagaat ttaattggga taaaaggaat
     9961 taatccagca agcacagtta gataccaaac tttataattt aaactataat taaaatagcg
    10021 ttttaatatg tacctaaaaa atactaacaa tagaaatata aaacaaaagc ttactacact
    10081 cattattagt aatttagcca tttttacacc ttctttcaaa tatttataat aaacaattga
    10141 catcaatatt acaattgtaa tattattgtt ttgtaaaaat tacaactgta atatcggagg
    10201 gtttattttg aaaaagttaa tatttttaat tgtaatggct ttagttttaa gtgcatgtaa
    10261 ttcaaacagt tcacatgcca aagagttaaa tgatttagaa aaaaaatata atgctcatat
    10321 tggtgtttat gctttagata ctaaaagtgg taaggaagta aaatttaatt cagataagag
    10381 atttgcctat gcttcgactt caaaagcgat aaatagtgct attttgttag aacaagtacc
    10441 ttataataag ttaaataaaa aagtacatat taacaaagat gatatagttg cttattctcc
    10501 tattttagaa aaatatgtag gaaaagacat cactttaaaa gaacttattg aggcttcaat
    10561 gacatatagt gataatacag caaacaataa aattataaaa gaaatcggtg gaatcaaaaa
    10621 agttaaacaa cgtctaaaag aactaggaga taaagtaaca aatccagtta gatatgagat
    10681 agaattaaat tactattcgc caaagagcaa aaaagatact tcaacgcctg ctgctttcgg
    10741 caagacttta aataaactta tcgcaaatgg aaaattaagc aaaaaaaata aaaatttctt
    10801 acttgattta atgtttaata ataaaaacgg agacacttta attaaagatg gtgttccaaa
    10861 agactataag gttgctgata aaagtggtca agcaataaca tatgcttcta gaaatgatgt
    10921 tgcttttgtt tatcctaagg gccaatctga acctattgtt ttagtcattt ttacgaataa
    10981 agacaataaa agtgataagc caaatgataa gttgataagt gaaaccgcca agagtgtaat
    11041 gaaggaattt taatattcta aatgcataat aaatactgat aacatcttat agtttgtatt
    11101 atattttcta ttatcgttga catgtataat tttgatatca aaacctgatt ttccctttat
    11161 tattttcgag atttattttc ttaattctct ttaacaaact agaaatattg tatatacaaa
    11221 aaatcataaa taatagatga atagtttaat tataggtgtt catcaatcga aaaagcaacg
    11281 tatcttattt aaagtgcgtt gcttttttct catttataag gttaaataat tctcatatat
    11341 caagcaaagt gacataattg ttgaatttat agtaactgaa acgtatgatt agggtgtata
    11401 ttaattatga gatggaaatc aatgattgtt ggctatgcga gagtatcatc gaacgatcaa
    11461 aatttagaaa gacaacttga aaatttaaag acgttttgtg ctgaaaaaat atttacagaa
    11521 aaacagtctg ggaaatctat tgaaaataga ccagtacttc aagaagcact taactttttg
    11581 aggatgggag atcggtttgt agtagaatcc attgattgtt taggtcgtaa ttatgatgaa
    11641 gtgattcata ccgttaatta tttaaaagac aaagaagtac aattaatgat tactagctta
    11701 cctatgatga atgaagtggt tggcaatcca ttactggata agtttatgaa agatttaatt
    11761 attcaaatat tagcaatggt ttcagaacaa gagagaaatg aaagtaaacg tcgacaagcg
    11821 caaggaattc aagttgcgaa ggaaaaaggc gtatataaag ggcgcccctt actttattca
    11881 ccaaatgcta aagatccaca gaaacgtatt atttatcatc gcgttgtaga aatgttagaa
    11941 gaaggccaat caattagtaa aattgcgaaa gaagtaaata taacaaggca gacgatttac
    12001 agaattaaaa acgataatga tttgatttaa taaactttgt ttcaatgcaa ctgagagctt
    12061 ctcacagcgt ctcaaaacag atgattataa tctattatga gtttttaata ataagacaag
    12121 aaaagagagc gtaaatatgc tctctctttt tctcattaac gaatgtttat aacgcaatca
    12181 tgatgagagt attaatacag ttaattattt gaaatacttt agtttatata atgttgaatt
    12241 ataggtagtg aaattgtatt tattatacat tgtcatatcg ttgtttaatg atagttaatt
    12301 taaggataat agaattaata ttatatatag atgaacaaaa caagcaacag agcagaaaaa
    12361 acacttttag attattttta atcattctct attttattta tttttgctat aataaataaa
    12421 gaatattaaa tggaggtgtt tttatgaaaa agaaatttgt ttctagttgt attgctagta
    12481 caatcttatt cggcacttta ttaggtgtaa cttataaagc tgaagctgca acagtacatg
    12541 tagctggtgg tgtttggagc catggtattg gaaaacatta cgtatggtct tattatagtc
    12601 acaataaaag aaatcatggt tcaacagcag tagggaaata ttcatctttt agtggtgttg
    12661 ctcgacctgg tgttcaatct aaggcatctg ctccaaaggc ttggggtgga aacaaaacat
    12721 tttatagtct tcactaatta catatattaa ttaaggagaa tagacagaat taagtaaact
    12781 taattctgtc tattctcttg aaagaggcaa tatgaaaaaa ttcaaattat ttttagattt
    12841 tagtacttta ttattaattt cagggctatt atttttattt ttcttcaaag aaaatgaaga
    12901 aattatacct gaaagttcca atattttaac aatctctaat tgggataaat ctaacagtaa
    12961 atcaaaagtg ttagatgtca ttgaatcagg cgccaaaaat caaaatatac aaataattaa
    13021 atccgttaaa gattttgata ataaaaaaga attttttgtt ttcaactcaa aacgaaataa
    13081 ttctgacttt atacgtaata aaacatcact tttaactcca tcagatttat taaacagaga
    13141 gataaaagga aagtattata ttattggtga acatttcaat gtagaagagc ttacgagtga
    13201 attaaaaaaa gctggtttaa catctgaagt tgaatacata aatagaaaca tattattttt
    13261 tgaattagtc atagataatg atttattagt gcctttcata ttcttaggcg tattatatct
    13321 tttgtacttc ttatatgaca gaggatataa tttgaaattt tatgctattc aaaagctaca
    13381 tggcttttca actacacgca ttatttttca taatattcat ataaaaatca tttattggct
    13441 agtacttacc gctattttct ttattgctaa tatattaatc attcatatag ccaatttaga
    13501 attggatttc ttaatgttta ttcgtagatt tatcgtgttg ctttttgttt ttgcttgtat
    13561 tactacattg ctgtggctga tttcgtatag tcttcttttg aagttaagta ttccattaat
    13621 cttaaaaggg aaaaaagggt ataagttttc aatatttatg ggtaccttca ccaaatgtat
    13681 catggtgcta atactatctt ttttactggc acaaaattta aatgcttata cgaagttaaa
    13741 gaatatatat gactctgaaa aaatctggca aaagttagat aattactata cattagagat
    13801 ttctcctaat attagaaatt cagaagaaaa acaaatttta gaaactaata tatacaattt
    13861 aattaagaaa agcgaacaac ttggtggatt gcttttaaag aataataata tagccaatcc
    13921 cgataaaaac aattacattc ctgaaaatgg caatgtcttt tttatcaata acaattttct
    13981 gaatttctat aaaaatataa atcatgattt taaaatgatt gacaatcatt cggataaaat
    14041 aaacgtgttt attcctccaa ggttacaata tcaaaaatct gaaattcaaa aaaatcacca
    14101 aggatggatt gactttcaaa agcaacaaaa caaaaaagta gatgtgcaag tactgtcaaa
    14161 aaacgtatct gttttttctt ttgatcgcac aactaatttg aaatttgggt atctagattc
    14221 tccaatagta atgttgttga cacttgacga tttaacagga gatttttatt tagctgctgt
    14281 ttctcaaggt ggatatctat ttaaagattt agatacactt aaacagttgc ttaaagataa
    14341 tcacctagaa gaagaaatta gcggtataac taattacaag gattctgtgt taaatgaatt
    14401 aaatgaaacg aaaacaaaaa tgataataac aatagttact attattatta acgttttcat
    14461 tcttttgata gctactgtat ttgaaacaat tcaatatttt agctggaata aaaagcaact
    14521 attattaaga aaaattcatg gttattcatt attcagcagt aatgtacgtt atttaacaat
    14581 ttctatctta ctttctatta tgttagctta cactacgcat attttatttg gttcaaagat
    14641 attactattc ataataatgt ctattgctat tattcaacat ttacttcaaa ttgcttatat
    14701 taaatatctt gaaaaatact ttaaagattt aatgagggag atttaaacaa tgaaaagaac
    14761 tttaattatt gtaacaattg tactattaat catcatactt agtctgttat tggttagaaa
    14821 tgagcattta gatcgtttta acccactgtt aaaagaaaaa gtatcttatg ccaaagttcc
    14881 aaaagatacc caggactata gaaatataac tgtatactct aaaaatggag aaaaaaagag
    14941 ttataaattg gattttttag gttatgatcc tacaaaagaa tatgtgaaag taaatcataa
    15001 agggaaatat gtgcgttcga tagaatacat tacaaaagat attcctagct ttttaaaatg
    15061 aggtgaccga tagtgataaa acttgaaaat gtttttgtaa aaaaaggtaa taaaaacatt
    15121 ttagacggat gtaactttaa ttttgaaaaa ggaaaatcat atgctttagt tggagaaagt
    15181 ggcgctggaa aatctacttt acttaacata atcgctgggt tcgaagatgt atcacaagga
    15241 agcatatata ttgaagataa gttactaaaa aagaaagtcg atttttatag atatacgtta
    15301 gggtatttgt ttcaaaattt tgctttactt gaaaatcaaa caatcagtca aaatttagat
    15361 ttagccctaa agttcaaaaa gaataaaaaa gataatatga acttaaagaa agaagtatta
    15421 aaaaaggtcg gcctagattt agatatcaag agaattgtta gttctctaag cggtggtgaa
    15481 caacaaagag tagcattggc aagattaata ttaaaagatc cgaaaatcat tttagctgat
    15541 gaacctactg ggtcactaga tacgaaaaat ggaaaaatag ttattgattt attattgaag
    15601 ctacttgatg aaaataaaac tatgattgtc gtaacgcatg atttagagct tgcgaaacga
    15661 tttgatgtca tagtcaatat ttctgagctt agaagttaag aaatattgat aggtatagcc
    15721 atacatagag aaaaaacaat atgaaatatg attagtcatt acttttgagt tttttaattt
    15781 aaggactgga ttttccagtc cttttttatg atgacaaaaa acaagcctcg cagagcacac
    15841 gtttttaatg acttatttgg tttttaataa gtctagtatg ttaaaacttt tctgtgttta
    15901 ggtgttataa tcatatgcag tggaagttga tttattatgt cttattcaat tattcgagtt
    15961 gttaaagtga aatcaaaaac aaatacaaga ggtattcaaa gacatattca aagagaaaat
    16021 aaaaattatg aaaatataga tattgattta agtaagtcat atttaaacta tgatttagtc
    16081 aatgatacta agtttgattt taataaaaaa attgatgaga aaatcgaaaa aaattataaa
    16141 gggaaacgca aaattagaac agatgccatt aaacatattg atggattaat tacatcagat
    16201 aatgtgtttt ttaatcaatt atctgaagaa gagacaaaat agttttttaa gcatgctaaa
    16261 gcgttcttgg aagaagaata cggtaaagaa aatcttttat atgcgacagt acatatggat
    16321 gagataacac cacatatgca ttatggcgta gttcctatta ctaaagatgg acgtttaagt
    16381 gcgaaagaag ttgtaggtaa taaaaaagca ttaaccgaat tccaagatag attcaatacg
    16441 tatattaata agcaaggcta tgatttaaaa cgaggaattt ctagacaact tacaaaagaa
    16501 aaacatgatc aagttagccg ttataaacaa aaaacagaat atcataaaca aatgcatatg
    16561 cgctagaagc aaatagagga ttatttaaag caagaaaatg ataaattgat acaaaactac
    16621 caaaaatcat tagatacgct taaaaagctt ctgagtgtca tgtatgaaat taaaactaaa
    16681 aatgtaggtg gatggtttca taaagagaag caagaaacag gcaatattgt aattactaaa
    16741 actgattttg aaaaatacac taaacaaatt aaagcagcac agatgatatt agatgattat
    16801 gaatgtatta aaagtgggaa gtcattaaaa aaagcagaga aacaaaatga aagtttagtt
    16861 aatgaattga ctagtgtcca tatggaaaat gaaaagctgg ttgaagaatt taatgattta
    16921 gcacaacgtt ataattattt gttgtcagag aatgaaaaga aagataaaga actaaattat
    16981 acgcttaagt tattcaatca agtttttaaa atcattaaaa gtatgatgaa agaagagcgt
    17041 tatcatacac taataaatca tattgataat catttagaca attctaaaat acgtgaagta
    17101 atgacgatag ataacaatga tgaacagttc tttaagaaga aatatcaagc acaagaacga
    17161 gaaatcattt ttaaagaaga tagagaagat ggttatacat tataaaaata gatatttaaa
    17221 tgcatttgtt tgaggttaat tattttttag gatgaaaaat aggtagcccc cctcgaactt
    17281 tttaatatat ttttataaat ctttttaaaa acctttttag gggctttttc agccctagag
    17341 caacaaggga tttcaatgcc taaaggagtg tttttgccac ataaaaggag tgtttttgcc
    17401 acataaaagg agtgtttttg ccacataaaa ggagtgtttt tgccacataa aaggagtgtt
    17461 ttaaaaagtt gtactccttt tatggtttga cattgataat aaagtagttt attgtgaata
    17521 aaagttttca aatgggagtg tatattcaaa cgatactcct ttaggttcgt aataaagggg
    17581 gctgtatcat gacaggagag acagttgtat ataaaaatga aatgaattta gttccattaa
    17641 ggcgatttac agctactgaa attaatttat tttttgcgat gtgtaataaa ttaaaagagc
    17701 aagatactaa tacattacgt ttgtcttttg atgaattaaa aaaattaagt aattatagtc
    17761 cagaaacacg taatattaat agatttgcta atgatttaga taatgtgtat aaaaagatgt
    17821 tgaatttaac cattagatat gaagatgatg atgtaataga aagattcgtt ttattcaatc
    17881 attatagaat ccataagcga gaacaatatc tagaaatatc aacttcttca aatttaaaac
    17941 acatattgaa ttcaattact aataatttta caaaatttga attaaaagaa atgactaggc
    18001 ttaaatctac atattctaaa aatatgttta gattacttaa acaatacaaa catacaggct
    18061 atttaaaaat tcacatcgat gattttaaaa atcgtttaga tatacctaaa tcttatcgta
    18121 tgactgatat taacaaaaat gtttttaaac ctattattat tgaattaggt tctatattta
    18181 ataatcttac tatcaataaa atcaaagcga aaaaagggcg taaaattgaa tggatagagt
    18241 tcacatttga cgctgagaaa cgcattcata acaaacgaca acctcaaatg tccaagatag
    18301 ataaatcaag acaatatgtg aggcgtgaaa agacgcctaa atggttagaa gaacggtcat
    18361 atgaaaagca acctcaaaaa gattacgacc cacaattaga gaaagaacga gaggattttt
    18421 taaaacaact tgaactgaat tgggaataac gcaacttttc gttgcgagtt ggttaactaa
    18481 aagtatcgtg acttttcaat tattttaatt atagtttgag ttaaggagtg attttatgaa
    18541 attagctgaa gctataaaag aacagagaga attaaaagga tggtctcaag aggaattagc
    18601 caatatatta aaggtttcca gacaaagtgt ttctaaatgg gaaagtgcca aaaactatcc
    18661 ttccttagat attttgattg ctatgagcga tttattcgga atctctttag agcatttaat
    18721 taaaggagat gcacgtttta aaaaagttat tttagaggga aattatagag agagtaacag
    18781 ggtaccttcc atagttgatt ttctttatga tttttggtgg cttttctttc ctgttgccgg
    18841 atttttagtt tgggccattc attcgttcat gggttgattt taaaatcaaa atttaatgca
    18901 catcaggcaa tatgaaaaag gaaagtattt ttacgacacc ttgaaatgta ttgataagaa
    18961 tagaagagtt tacaaaaggc aatatgaaat atatactaaa agtaacaaga atttcgtttg
    19021 taaacgcaca aaaccccgaa ctattcgccg tagttcgggg ttttttggtg aattggcttt
    19081 aatcgtctat attatttttt atcacgttta tggagctaat aaccaaataa cgtaacgaga
    19141 caaccactga ttgccgttgt catgatgtga acaagaattt cattcataaa tcgcacctcc
    19201 tctctacgcc gaattgacat ctgagagata gacgaccttc acattataac aaatctctcc
    19261 ttccatgaaa taacatgaat attaataaat gttgttatat attaaagata aataaatata
    19321 agggtgggat tgataatgtt tggcgatcaa agacaagaag ctacaaaata tgtcattaaa
    19381 gaaggttatc aagatattta tttcctcaac aaaaacgggg aatggtatta tttcgaagta
    19441 agaagtgtct ggcgtggcaa acatattatt agagttaaag atggtttgtt aggttggaga
    19501 aaagaaatag taactgaata aagatacaaa atacttgcca atgcaaaaga atgaaaacgc
    19561 gtcaaatcaa cgatgtataa aagatgcata aaagataatg aaagtaaaaa gccataaatg
    19621 ccgtcatata ggcatttatg gctttttgtt tggttaacat aatcgatgat tatcagaagt
    19681 tcaattcaca taaaaaagca cggctaattt atgaacttgt cgtacctttt taattaaaat
    19741 tagttaccaa atagacgact ccaaaacccc tttttaggtt ccgtttcttc actcttttct
    19801 tctatatcac tatcattgtc atttggatta gctgaaacgt cttctctttg tgcttcttca
    19861 ccttgtgtac tttcgtcgct ttgacttcca gatatatcct tatattgaat ctctgtttct
    19921 ttagtttctt cctgatctcg gttaatattt acaggactag tagtatatgt tttttcttgt
    19981 gcatcaacgt tttgtctagc gttagtagat gtatcaaagg gataattaag gtgtttttct
    20041 ttttctaatt gattttctaa tttttgaatc tttttattac tctctaatgc cagaacttgc
    20101 tgattctcaa gcaattttga tctttcttgc aactcttttc tgtaaaattc aattgttgtt
    20161 tcatgacgac tttcttgttt ttcaatttga ttatttaaag tattaatctg atttttaagt
    20221 atttctacta tttgagcatc gcttttagat tcaaaattaa tattatccga ctcttttttt
    20281 tgtttgtctt cagtagcact ttcaaaacca tatttctttt tattttcatt tactctttga
    20341 atgatttttt ctatatcggt atcttcttta ataaacgaag tgttttcctg ttttattgtc
    20401 tctatattca atctcttaat attattaaaa atcgtttgct tactaacccc taattcttca
    20461 ctcaaccttt ttacactttt catatcatca accctttata aaatgtttat aaacccttag
    20521 taaaatatta taagcttata acgattaata ataaagtaat cgacaaataa aaatataaat
    20581 tcgccaacct ttttatcaag ggtttgtaaa gggtttatgg tgtttatcaa aggtttataa
    20641 acctatattt tccctttttt aagtttattc aaagtgctat aataacctta atataacaaa
    20701 aaccccaact actggtaata gtcggggt
//
