LOCUS       CP127632               20653 bp    DNA     circular BCT 19-JUN-2023
DEFINITION  Staphylococcus aureus strain C25 plasmid pC25_1, complete sequence.
ACCESSION   CP127632
VERSION     CP127632.1
DBLINK      BioProject: PRJNA914892
            BioSample: SAMN32360915
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 20653)
  AUTHORS   Bouras,G., Houtak,G., Nepal,R., Shaghayegh,G. and Vreugde,S.
  TITLE     Hybrid Oxford Nanopore Technologies Illumina Sequences of 174
            Staphylococcus Aureus Isolates from Chronic Rhinosinusitis Patients
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 20653)
  AUTHORS   Bouras,G., Houtak,G., Nepal,R., Shaghayegh,G. and Vreugde,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-JUN-2023) Department of ENT Surgery at the Basil
            Hetzel Institute, Adelaide Medical School, The University of
            Adelaide, 37 Woodville Road, Woodville South, SA 5011, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 14-NOV-2022
            Assembly Method :: Flye for Genome, plassembler (Unicycler) for
            plasmids v. 2.9.1 (Flye) with short read polishing, 0.1.1
            (plassembler) with 0.5.0 (Unicycler)
            Assembly Name                     :: C25
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 49x
            Sequencing Technology :: Oxford Nanopore MiniION and Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 06/11/2023 01:42:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.5
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,694
            CDSs (total)                      :: 2,612
            Genes (coding)                    :: 2,532
            CDSs (with protein)               :: 2,532
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 80
            CDSs (without protein)            :: 80
            Pseudo Genes (ambiguous residues) :: 0 of 80
            Pseudo Genes (frameshifted)       :: 48 of 80
            Pseudo Genes (incomplete)         :: 28 of 80
            Pseudo Genes (internal stop)      :: 14 of 80
            Pseudo Genes (multiple problems)  :: 9 of 80
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..20653
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="C25"
                     /isolation_source="Patient Sinus Swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pC25_1"
                     /geo_loc_name="Australia: Adelaide"
                     /lat_lon="34.9285 S 138.6007 E"
                     /collection_date="2011-09-26"
                     /collected_by="ENT Surgery Department at the Queen
                     Elizabeth Hospital, Adelaide, Australia 116"
     gene            166..842
                     /locus_tag="PCL85_13355"
                     /pseudo=""
     CDS             166..842
                     /locus_tag="PCL85_13355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /name="replication initiator protein A"
     gene            853..1135
                     /locus_tag="PCL85_13360"
                     /pseudo=""
     CDS             853..1135
                     /locus_tag="PCL85_13360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199895.1"
                     /note="frameshifted; internal stop; incomplete; partial on
                     complete genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology. GO_function: GO:0003677 - DNA binding
                     [Evidence IEA]; GO_process: GO:0006260 - DNA replication
                     [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            2344..2961
                     /gene="cadD"
                     /locus_tag="PCL85_13365"
     ARG             2345..2958
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="99.51"
                     /coverage="100.0"
     gene            2980..3327
                     /locus_tag="PCL85_13370"
     CDS             2980..3327
                     /locus_tag="PCL85_13370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]; GO_process: GO:0006355 - regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WJA56067.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNQEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            3496..3588
                     /locus_tag="PCL85_13375"
     CDS             3496..3588
                     /locus_tag="PCL85_13375"
                     /inference="COORDINATES: protein motif:HMM:NF033608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WJA56068.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            3800..4774
                     /locus_tag="PCL85_13380"
     CDS             3800..4774
                     /locus_tag="PCL85_13380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4062 domain-containing protein"
                     /protein_id="WJA56069.1"
                     /translation="MSNTKIKYQIFISSTYLDLIEERQAVVEAVLNSNNIPAGMELFNS
                     SSKSQWEIITQWINESDAVILLLGSSYGTIDSEENISYTEMEYNFAKSLGKPIYVFEMN
                     KASTESAEKSKKLDEFKTKVKENRLISPNINDISELKSKVSQTLMQSVPSEIKENSGWI
                     RVQDCGKNVKKLKKLDAIQRDLDTYDFLKEELYKIFMYVKTFYFQHTPFDDSYIEDIEN
                     YLLNYENNPHKSFMKIKVYDYKNFLKHLKNILILIKQGKKPLAQAGHFKLSFYEEDLKL
                     LQKNYKATLVDIKGLNKHFYKECDRCLKAYNIFIEGINKHLYE"
                     /name="DUF4062 domain-containing protein"
     gene            complement(4894..5709)
                     /locus_tag="PCL85_13385"
     CDS             complement(4894..5709)
                     /locus_tag="PCL85_13385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019467708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WJA56070.1"
                     /translation="MTKNQNFIETKEYKRFAEFCDACIKYQYIGICYGQPGVGKTLSSR
                     YYTNWDTIEKQVNHRGWEDLASKTTDDILSVDKIFYNAPAEKQTKLRNDLYSITAIIDL
                     GQKLHVVNKYGHEHSKHYSDMFKYIDLIIVDEIDRLKVQHLEQLRAIYDEHNLAMIFIG
                     MPGIEKKLSRYPQLYSRIGFAHEFDNLSKDETHHILEYKWQDLGFDLKLEDFTDYEAIT
                     TIIKITKGNFRLIHRLFAQIDRIMDINGLDKISTEVVETARDSLVIGIR"
                     /name="AAA family ATPase"
     gene            complement(5702..7145)
                     /locus_tag="PCL85_13390"
                     /pseudo=""
     CDS             complement(5702..7145)
                     /locus_tag="PCL85_13390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790716.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_process: GO:0015074 - DNA integration [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DDE-type integrase/transposase/recombinase"
                     /name="DDE-type integrase/transposase/recombinase"
     gene            complement(7117..7710)
                     /locus_tag="PCL85_13395"
     CDS             complement(7117..7710)
                     /locus_tag="PCL85_13395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WJA56071.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNQKDLNLLKTLYDNGTPI
                     KTIAEQWHVSRTTIYRYLNKLEDKEDEKQGEVSN"
                     /name="recombinase family protein"
     gene            complement(7974..8354)
                     /gene="blaI"
                     /locus_tag="PCL85_13400"
     ARG             complement(7978..8354)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            complement(8344..10101)
                     /gene="blaR1"
                     /locus_tag="PCL85_13405"
     ARG             complement(8348..10101)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.56"
                     /coverage="100.0"
     gene            10208..11053
                     /gene="blaZ"
                     /locus_tag="PCL85_13410"
     ARG             10209..11050
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            11422..11955
                     /locus_tag="PCL85_13415"
     CDS             11422..11955
                     /locus_tag="PCL85_13415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001823239.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WJA56075.1"
                     /translation="MIVGYARVSSNDQNLERQLENLKTFCAEKIFTEKQSGKSIENRPV
                     LQEALNFLRMGDRFVVESIDCLGRNYDEVVGNPLLDKFMKDLIIQILAMVSEQERNESK
                     RRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRIIYHRVVEMLEEGQSISKIAKEVNIT
                     RQTIYRIKNDNDLI"
                     /name="recombinase family protein"
     gene            12369..12662
                     /locus_tag="PCL85_13420"
     CDS             12369..12662
                     /locus_tag="PCL85_13420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WJA56057.1"
                     /translation="MKKKFVSSCIASTILFGTLLGVTYKAEAATVHVAGGVWSHGIGKH
                     YVWSYYSHNKRNHGSTAVGKYSSFSGVARPGVQSKASAPKAWGGNKTFYSLH"
                     /name="lactococcin 972 family bacteriocin"
     gene            12737..14671
                     /locus_tag="PCL85_13425"
     CDS             12737..14671
                     /locus_tag="PCL85_13425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001670421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="WJA56058.1"
                     /translation="MKKFKLFLDFSTLLLISGLLFLFFFKENEEIIPESSNILTISNWD
                     KSNSKSKVLDVIESGAKNQNIQIIKSVKDFDNKKEFFVFNSKRNNSDFIRNKTSLLTPS
                     DLLNREIKGKYYIIGEHFNVEELTSELKKAGLTSEVEYINRNILFFELVIDNDLLVPFI
                     FLGVLYLLYFLYDRGYNLKFYAIQKLHGFSTTRIIFHNIHIKIIYWLVLTAIFFIANIL
                     IIHIANLELDFLMFIRRFIVLLFVFACITTLLWLISYSLLLKLSIPLILKGKKGYKFSI
                     FMGTFTKCIMVLILSFLLAQNLNAYTKLKNIYDSEKIWQKLDNYYTLEISPNIRNSEEK
                     QILETNIYNLIKKSEQLGGLLLKNNNIANPDKNNYIPENGNVFFINNNFLNFYKNINHD
                     FKMIDNHSDKINVFIPPRLQYQKSEIQKNHQGWIDFQKQQNKKVDVQVLSKNVSVFSFD
                     RTTNLKFGYLDSPIVMLLTLDDLTGDFYLAAVSQGGYLFKDLDTLKQLLKDNHLEEEIS
                     GITNYKDSVLNELNETKTKMIITIVTIIINVFILLIATVFETIQYFSWNKKQLLLRKIH
                     GYSLFSSNVRYLTISILLSIMLAYTTHILFGSKILLFIIMSIAIIQHLLQIAYIKYLEK
                     YFKDLMREI"
                     /name="bacteriocin-associated integral membrane family
                     protein"
     gene            14675..14986
                     /locus_tag="PCL85_13430"
     CDS             14675..14986
                     /locus_tag="PCL85_13430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YxeA family protein"
                     /protein_id="WJA56059.1"
                     /translation="MKRTLIIVTIVLLIIILSLLLVRNEHLDRFNPLLKEKVSYAKVPK
                     DTQDYRNITVYSKNGEKKSYKLDFLGYDPTKEYVKVNHKGKYVRSIEYITKDIPSFLK"
                     /name="YxeA family protein"
     gene            14998..15624
                     /locus_tag="PCL85_13435"
     CDS             14998..15624
                     /locus_tag="PCL85_13435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WJA56060.1"
                     /translation="MIKLENVFVKKGNKNILDGCNFNFEKGKSYALVGESGAGKSTLLN
                     IIAGFEDVSQGSIYIEDKLLKKKVDFYRYTLGYLFQNFALLENQTISQNLDLALKFKKN
                     KKDNMNLKKEVLKKVGLDLDIKRIVSSLSGGEQQRVALARLILKDPKIILADEPTGSLD
                     TKNGKIVIDLLLKLLDENKTMIVVTHDLELAKRFDVIVNISELRS"
                     /name="ABC transporter ATP-binding protein"
     gene            15862..16491
                     /gene="mobV"
                     /locus_tag="PCL85_13440"
                     /pseudo=""
     CDS             15862..16491
                     /gene="mobV"
                     /locus_tag="PCL85_13440"
                     /inference="COORDINATES: protein motif:HMM:NF013258.2"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MobV family relaxase"
                     /name="mobV"
     gene            16585..17130
                     /locus_tag="PCL85_13445"
     CDS             16585..17130
                     /locus_tag="PCL85_13445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001805533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase"
                     /protein_id="WJA56061.1"
                     /translation="MYEIKTKNVGGWFHKEKQETGNIVIIKTDFEKYTKQIKAAQMILD
                     DYECIKSGKSLKKAEKQNESLVNELTSVHMENEKLVEEFNDLAQRYNYLLSENEKKDKE
                     LNYTLKLFNQVFKIIKSMMKEERYHTLINHIDNHLDNSKIREVMTIDNNDEQFFKKKYQ
                     AQEREIIFKEDREDGYTL"
                     /name="recombinase"
     gene            17514..18374
                     /locus_tag="PCL85_13450"
     CDS             17514..18374
                     /locus_tag="PCL85_13450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WJA56062.1"
                     /translation="MTGETVVYKNEMNLVPLRRFTATEINLFFAMCNKLKEQDTNTLRL
                     SFDELKKLSNYSPETRNINRFANDLDNVYKKMLNLTIRYEDDDVIERFVLFNHYRIHKR
                     EQYLEISTSSNLKHILNSITNNFTKFELKEMTRLKSTYSKNMFRLLKQYKHTGYLKIHI
                     DDFKNRLDIPKSYRMTDINKNVFKPIIIELGSIFNNLTINKIKAKKGRKIEWIEFTFDA
                     EKRIHNKRQPQMSKIDKSRQYVRREKTPKWLEERSYEKQPQKDYDPQLEKEREDFLKQL
                     ELNWE"
                     /name="replication initiation protein"
     gene            18461..18802
                     /locus_tag="PCL85_13455"
     CDS             18461..18802
                     /locus_tag="PCL85_13455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WJA56063.1"
                     /translation="MKLAEAIKEQRELKGWSQEELANILKVSRQSVSKWESAKNYPSLD
                     ILITMSDLFGISLEHLIKGDARFKKVILEGNYRESNRVPSIVDFLYDFWWLFFPVAGFL
                     VWAIHSFMG"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(19041..19112)
                     /locus_tag="PCL85_13460"
     CDS             complement(19041..19112)
                     /locus_tag="PCL85_13460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WJA56076.1"
                     /translation="MNEILVHIMTTAISGCLVTLFGY"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            19261..19446
                     /locus_tag="PCL85_13465"
     CDS             19261..19446
                     /locus_tag="PCL85_13465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WJA56064.1"
                     /translation="MFGDQRQEATKYVIKEGYQDIYFLNKNGEWYYFEVRSVWRGKHII
                     RVKDGLLGWRKEIVTE"
                     /name="hypothetical protein"
     gene            complement(19665..20408)
                     /locus_tag="PCL85_13470"
     CDS             complement(19665..20408)
                     /locus_tag="PCL85_13470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WJA56065.1"
                     /translation="MKSVKRLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESATEDKQKKESDNINFESKSDAQIVEILKNQINTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNAR
                     QNVDAQEKTYTTSPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAQREDVSANPND
                     NDSDIEEKSEETEAKKGFWSRLFGN"
                     /name="DUF536 domain-containing protein"
     ARG             10209..11053
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     BGC             7369..17662
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          1193..1340
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="81.333"
                     /coverage="100.0"
                     /evalue="2.96e-25"
     Typing          17515..18374
                     /name="rep_cluster_2214"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(19666..20408)
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          15863..16137
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="94.565"
                     /coverage="100.0"
                     /evalue="4.71e-46"
ORIGIN
        1 ttggtaataa aacgtttaga aactgtttat ttatataatt ttcgatactt agattatata
       61 atgaataata tcttagtgca agcacctaga ttattaaata aacacaaaaa atgtaagcgt
      121 tttattacct cttaccaaac taaaattcgg aaagaggttt ttattatgtc aattaaactt
      181 tacaacataa atgaggaata cagagaaaag ttttatcaaa taccgaaagt attttttaca
      241 aatcctaaat atatcaagtt atccaatgat gcaaaaatgg catggggtat tcttagagat
      301 cgtttagatt tatcaattaa aaatggttgg gttgattcta aaacaggtaa tatttatttt
      361 tattacaaaa atgaaaaccc acaaaatata ttaaattgta aaaaagataa agtaattaaa
      421 ataaagaaag aacttaattg aagccgaatt actactacaa gaaagacaag gtttaaataa
      481 gacaaataaa ctttatttag ttaaaccaga agtaacagaa gatgatattt ataaaattca
      541 aaagcaagaa aacactgttg agagcagcaa tggcaaggaa gtcggaaaaa ccgacttcaa
      601 gaagtcgata aaacagaatc taatgatact gaacttagct atactgaatc taacaatact
      661 gaaataaatg atatgaatga cttgaatgat atagagtccg aaaatgaaat tagtaatcat
      721 tcaagtcaat gcaaggttat ttaatgcaaa caattttaac tgaatttgaa gaaacacatg
      781 cactttatat gcgccgtaaa aacatgaaac aatataatat ctttaatcaa tcattcaaat
      841 gattttataa caatcaaaga tacatcaaaa tatttcgtta aatcatctga ctttttaact
      901 gatagcgatg aaaaaatcaa gaaattgtca gtgatctaga aaaagatttg tatcgaaaac
      961 gtatgttaag ttatggtgga ttgcttaaat aaaaacataa aattttaaac ttagacgatg
     1021 ctgaagatgg caatttaatt aatacaagtg atgaagataa aatagcaaat gaagaagaaa
     1081 aggcacattc gattacggca attttgaaaa gcaaaattat tatttaaggc attagtgata
     1141 actgatgtct ttttttatta cttttttgta aaaaaagtgc tgtcttattt ttgtgacaaa
     1201 tgctgtatgt agtgtcacaa aagtgtgaca cttgagcttt ttatgacccc acacaaaaac
     1261 attttcgaag ccttgaaata tctggctttg ccagatcccc cattcattga tggggacaaa
     1321 tttcccttat gctcttacgg agattttaga gttaaattaa aatttctaag tttttgataa
     1381 gaaaagccct gcaggaattt agaagaacgt ggggaagttt taaagaattt tatgctaatt
     1441 tttaatttgc atgtaaatgg gcagtgtcta aaaaatagtt attgtttttg ctcaaatttt
     1501 tgtttttgaa aatagcatat atttatttgg ctcatatttg cgttttaaaa gcgtatataa
     1561 gttttagata aaactatatg aatcacccct aaatctttaa aatgccctct taaaattcaa
     1621 aataagggca taaaaaataa aagccccccc agataaagtg aggtagcttt ttctttcgac
     1681 gccgtatcgt cgatgtaatt caaaaaagtt atgggctata aatctacatc actttttcaa
     1741 gaatgtagta gcaatattca acgcaaatta atttttataa ctgctcggaa tatctcaagc
     1801 cgtttcttta attttgaaat aaaaaaatcg acgaaggtcg attacgtttt tgcacatgtc
     1861 gatttatccg acgtataagt gcgcccttac gggatttaac tagattataa cgacgaattt
     1921 tagacctgta aagcaataac aattaggtct accaggtaga taaagtgtac aaagtagaac
     1981 cgaaaaagtt atttattttg aagatttttc gtagatataa tttgctaata aacttcctaa
     2041 aactgaataa agaaaaatag ttaaactcat gtaatcactc cataattctg aagtgtctcc
     2101 atgtctacgc atagacacgc atttatgccg agaaaattta ttgtgcgttg agaagaaccc
     2161 ttaactaaac ttgcagacga atgtcggcat agcgtgagct attaagccga ccattcgaca
     2221 agttttggga ttgttaaggg ttccgaggct caacgtcaat aaagcaattg gaataaagca
     2281 cctatgatta tttaaaaata taagttataa tacattcaaa aatatttttg aatgaggtgt
     2341 attatgattc aaacggttgt tgctgctgct gttctttata ttgctacagc agttgattta
     2401 ttagtaattt tattaatatt ttttgctaga gcaaagacta gaaaagaata tagaaatatt
     2461 tatgttggtc aatatttagg gtctattatt ttaatattag ttagtttgtt tttagctttt
     2521 gtattaaatt atgttccaga aaagtggata ttaggtttat tgggtttaat accaatttat
     2581 cttggaatta aagtggctat ttatgatgat tgtgaaggag aaaagagagc taaaaaagaa
     2641 ttgaatgaaa aaggattgtc taaattagtt ggtacggttg caattgttac gatagcaagt
     2701 tgtggcgccg ataatattgg tttatttgtt ccttattttg tgacattaag tgttactaat
     2761 ttattactta ctctgtttgt ctttttaatt ttaattttct tcttggtgtt tactgcacaa
     2821 aaattagcta atatcccagg aattggagaa attgttgaga aatttagtcg ttggattatg
     2881 gctatcattt atatagcttt aggtttattt attattattg aaaatgacac tattcaaaca
     2941 attttaggat ttatatttta atttagggtg tgattttata tgagttatga aaatacttgt
     3001 gatgtgatct gtgtacatga ggataaagtt aacaatgctt taagtttttt agaagatgat
     3061 aaatctaaga aattacttaa cattttagaa aaaatttgtg atgagaagaa attgaaaatc
     3121 atattatctt tgattaaaga agatgagttg tgtgtttgtg atatttcttt gatattgaaa
     3181 atgagtgttg cttcaacttc acatcattta aggcttttat ataaaaatga ggtacttgat
     3241 ttttataaag atggaaagat ggcatattat tttattaaag acgatgaaat aagagagttt
     3301 ttctctaaaa atcaggaggg tttttgaaac gagtgaaacg agtttcttct tgtcttgata
     3361 ctataaaaaa caaagttata taacataaga cgacttatcg gaagttatct atcatcgtat
     3421 attcggagat gatataatat acaggtcgcc tatctctcag gcgtcaattc agacgcagag
     3481 aggaggtgca ttactttgct aatcattttc gttcacatca tagcaccagt catcagtggc
     3541 tgtgctgttg cgtattatac ttattggctt agtaaacgca acaaataatt aataggcgac
     3601 tttataagcc agcatcgaaa aaatccccac actattgcag tagtgtgggg attggtgcat
     3661 taattgttaa tcattttcgt tatctagatt ataacactgg ttagtagagg aatgcaaaaa
     3721 gataatattt taagtagtct ttttggatat tatcatatga tatatttatg taaattgatt
     3781 ttttattaaa ggagcatata tgagtaatac taaaattaaa tatcaaattt ttatttcatc
     3841 aacttattta gatttaatag aagagcgtca agcagtagta gaagcagttt taaacagtaa
     3901 taatattcca gcaggtatgg aactttttaa ctcaagtagt aaaagccaat gggaaataat
     3961 aacacaatgg atcaatgaat cagatgcagt gatattattg ttaggttcta gttatggaac
     4021 aattgatagt gaagaaaata ttagctatac agaaatggag tacaattttg ctaaatcttt
     4081 aggtaaacct atatatgttt ttgagatgaa taaagcatct accgaatccg cggaaaagtc
     4141 taaaaaatta gatgagttta agacaaaagt taaagaaaat agactaatta gtccaaatat
     4201 taatgatatt tcggaattaa aaagtaaagt atctcagact ttaatgcaaa gtgtacctag
     4261 tgaaattaaa gaaaatagtg gatggataag agtacaggat tgtggtaaaa atgtaaaaaa
     4321 attaaaaaaa ttggatgcta tacaaagaga tttagataca tatgattttt tgaaagaaga
     4381 actttataaa atattcatgt atgtaaaaac tttttatttc cagcacacac catttgatga
     4441 tagttatatt gaagatatag aaaactacct gctaaattat gaaaataatc cacataaatc
     4501 attcatgaaa ataaaagttt atgattataa aaacttttta aaacatttaa aaaacatatt
     4561 gattttaatt aaacaaggaa aaaagccatt agctcaagcc ggtcatttta aattaagctt
     4621 ttacgaagag gatttaaaat tgttacaaaa aaattataag gctacgctag tcgatattaa
     4681 aggattgaat aaacattttt ataaggaatg tgataggtgc ttaaaagcat ataatatttt
     4741 tattgagggt ataaataaac atttatatga atgatataag tacaccctaa tcatacatat
     4801 ataattgttg tcactttact cgatatatga gaatgacttt acctaataaa tgagaaaagc
     4861 aacgcactat attaaaatgc gttgcttttt ctattatcga atacctataa ctaaactatc
     4921 tctagctgtt tctacaactt ctgtacttat tttatctaaa ccatttatat ccataattct
     4981 gtctatctgc gcaaataaac gatgaatcag cctaaaattc ccttttgtaa ttttaataat
     5041 cgtcgttatt gcctcataat cagtaaagtc ttcgagtttt aaatcaaatc ctaagtcttg
     5101 ccacttatat tctaatatat gatgcgtctc atctttactt agattatcaa attcatgcgc
     5161 aaaacctata cgcgaatata gttgaggata acgagatagt tttttctcta tacccggcat
     5221 accaataaat atcattgcta aattatgttc atcataaata gctcttaatt gctctaaatg
     5281 ttgcacttta aggcgatcaa tctcatctac tataattaaa tcaatatatt taaacatatc
     5341 actataatgt ttactatgtt catgtccata cttatttaca acatgtaatt tttgacccaa
     5401 atcaatgatt gcagtaatac tatataaatc attccttaat ttagtttgtt tttctgctgg
     5461 tgcattataa aatattttat ccaccgatag tatgtcatcg gtcgttttac tagctaaatc
     5521 ttcccaacct ctatggttaa cttgtttttc aatagtatcc caatttgtgt aatacctaga
     5581 cgataaagtt tttccgacac caggttgacc ataacatata ccaatatact gatatttaat
     5641 acaagcatca caaaattcag caaagcgttt atactctttc gtttcaatga aattttgatt
     5701 tttagtcatt acgatatctc tttaattttt tgacgttttt agtcgtttct tgaggtgaat
     5761 aaccacaatt tttttcttcc ttaattaatt ccgtggtact tggactagca atattttgtt
     5821 ttaagtgttt tcttctctga ctacgagcgt gctgtatgtc ttttatatct atggagtaat
     5881 cagctatttc tggacatata gcagtacaaa gaaattcatc tctataaaac acacgtattt
     5941 cagccatatc atttgggtta taacgaatca gtacatattc acctacataa gcttctagat
     6001 tagtattact gtatcgaaaa ccttgaaaat gaatgccatc tgaatgaact tttctagatt
     6061 taggtatttc caacaataat aaatcaagtt gttctaagct acttggcata ttagggaaaa
     6121 agtgattact attccaatga ctgataggcg tggtatgaat agtactatgt tctttttgat
     6181 tataatcttc aattaaaaag taacgtaatt tttcttcaaa attgtgaaaa tttattagat
     6241 tactaggagt atcattattg tttatatatc caggcagttg ttctaagaaa gtttgattaa
     6301 ctgtctgaaa gaatcgttct atttttccac gaccacgagg aacaccaact ttcgaaaaca
     6361 tcaagttaat tttcaaatca atagcgactt gttccatatg atgtgaagta aagtcacttc
     6421 catgatctgt gtagaatttt tcgggtatac cacacactgg ccaattggta tcatttttat
     6481 tccatattgc ttggtgtagt gttaatgctg tgttttgagc attggggggc atcaaaactt
     6541 aagaaatagc ctgcaattgc acgactatag tcatccataa taatagttag ccatggtcta
     6601 ttgatattac ctttttggtc taatataaag atatctagca aagtatggtc tgcttgccat
     6661 atttcattgg gtctcgagga ttctctaatt tgtattaaat cgtacttatt ttgatagtat
     6721 ttttcaccct gatgagagaa atcaataaca gacttaggca tcgctttaat aacactataa
     6781 atttgtttat aacttggtat atcaaaatta ttttctttac agtaattagt gattttccta
     6841 tgaattgtgg ctatactatt tcttttattc ataagcgcaa ggcgttcaat ttcatcaatt
     6901 atctttggtt ctattttacg tgttccttta tcagctcttg tagcatagat tagtccttta
     6961 agtccttgtt ctttatatga cttattccac ctataaaggg tgcttaacgc aatcccttta
     7021 cttttagaaa tacttgataa agattgttcg cctaggataa aaggttttat aatattgtac
     7081 ttttgagtag cttttttacg tttggcttca gaaaaattag ttagatactt ctccttgttt
     7141 ttcatcttcc ttgtcctcca atttattgag gtaacgataa attgttgtac gtgaaacatg
     7201 ccactgttct gcaattgtct taattggcgt gccattatca taaagggtct taagtaagtt
     7261 taaatctttt tgatttaatt tttctggtct gcctccatat cggcctctag cacgtgctgc
     7321 aattcggcca gctgaagaac gctctaaaat taaattacgt tcaaattctg caaatgctgc
     7381 gaataaatga aataataatt gtccagttga acttgattta tccattgtta tattttcttc
     7441 taaactatgg aaacttacac ctcgttcgtt aagctcatta actaatgtga ttaaatcctc
     7501 catattacgt cccaatctat ctaatctcca aacaacaatc gtatctcctg acctcgcaaa
     7561 ttcaattgct ttatctaaac caggtctttt actttttgaa ccactcatat ggtcattaaa
     7621 tatcttttca caaccatatg tatttaatcg atcctcctgt aaatttaaat tttgtaatcc
     7681 agttgaaact cttgcataac ctattttcaa aatacaaacc tcctatatac atcttcagtg
     7741 taccataact taattacaag gtcttttatg aacatagatt ttttgttggg tttttgaaca
     7801 cataatccta tgtaattctt acttatttag acataaaaga agagtgtaca gaaaatggtt
     7861 attttctgta cactctcatc tttaataata tattttaaat gtcattaaca aaactaattt
     7921 aataagagtc aagcatagtt tacatatgta ttatgtttga aacatacctc taattacttt
     7981 ttactaatat catttaaaat atctcgcaat tcttcaattt ctttgttatt taattcttca
     8041 tttttcgcaa aattcaacac taaacttttc atatcccctc catacagttt attaagaaag
     8101 gttttagcag ttttcatttt aatatcgtct tctttaatat ttgatgagta aaaataaata
     8161 ttttctgatt tgtatcgttt tataatctct tttttatata gtcttgtgat taatgttcta
     8221 atcgttttat cactaacttc tttatatttt tgaatttcaa ctacaatttc attagctgat
     8281 actgattttt tatcccatat tatattcata acatcccatt cagccataga tatttcaact
     8341 tgcttattgg ccatttaaaa cacccattcc ttttaatatt ttttcactta ttaattcagc
     8401 atttttccca gacgggtttc catctgataa atgtgtagca aaataatact tatcatgatt
     8461 tgtaattacg taacctacaa accacccatt attatacttc ccgtttacta tacctgtacc
     8521 tgttttccca tacagttcat acttttcatt tttcttaatc aataatgaag aagataattg
     8581 attctttgct tttttactaa aatggttatt ttgttccatc atatttttaa aaactattac
     8641 ttgttcaaga ttagatattt tcaaactatc ttccatccaa tagcttttat aacttcccaa
     8701 attttcatta ccataattta attgcttgag ttgagccgca gtatagttct ttggtatttg
     8761 attactaata cgttcgaagt accaattaac tgaattttgc attgctgtat ttaaatcttg
     8821 ttccttattc caagactcga aaagataatg tttatgattc catgacatac gtgaattttt
     8881 atcacttata atatgacggt caagtccaaa cagtgctaaa taaattttgt aagttgaatc
     8941 aggagaatat ctttttctac tttctttttc attataaata tagtatttgt ctttcttcat
     9001 gctgtacata acgaaagatc cactatttga accaaaattt ttactttcat ctaaaatttg
     9061 gtaatcgctt tgtaagggct ttttataatt ataatcagtt aaggattgcc ccattaaaaa
     9121 ctggctttga attatcatga taaaaaaagt aaaaatacaa ataaaaatta gaattaattt
     9181 tgactgcttt ttcagatcgg cttcttttat attaattaat ctatttttga gtaatgattt
     9241 tttaccatta aatgaatggc ttaatatatt tttgttgaaa aatgaggttt ttaatacgga
     9301 gtccataata gattccgcat aagttttaaa ttcatttttg ttaatattat taaggacaaa
     9361 tctatcggct tctacttcat tgtcatgaat tatctttctt tttacaatat gtactaatgg
     9421 attgtaactc ataataatag agaagatatt aaagataatt aaatgtaaag tatctctatt
     9481 tttagcatga gcatattcat gcagtattat atattttagt cttttatcaa ttacactttt
     9541 aaaatatgaa ctaggaatca aaataatata tttcccatac caaaaagtta ttggagattg
     9601 aatagcctct gcttttcgaa tcacaatatt ttttttatat tgatggttga aaagtatcgt
     9661 atctatttta tttttttcat tttcgtttag ataaagtgac tgtttcttta aatatttaag
     9721 atataataag gctttcaaaa atttaaaact taaaataata actaaaacta tccaaataac
     9781 tgtgcagata ttatcaattg aatcccaatt aaacttatgg atatctgttg cgaactcttg
     9841 aacaggtttg gtggtaatta tgttatggtt caagtcgtgt gacttacttt caactgtggg
     9901 cgcttgatta ttcacattat taaattttat aaaagagaat ttaattggga taaaaggaat
     9961 taatccagca agcacagtta gataccaaac tttataattt aaactataat taaaatagcg
    10021 ttttaatatg tacctaaaaa atactaacaa tagaaatata aaacaaaagc ttactacact
    10081 cattattagt aatttagcca ttttgacacc ttctttcaaa tatttataat aaacaattga
    10141 catcaatatt acaattgtaa tattattgtt ttgtaaaaat tacaactgta atatcggagg
    10201 gtttattttg aaaaagttaa tatttttaat tgtaatggct ttagttttaa gtgcatgtaa
    10261 ttcaaacagt tcacatgcca aagagttaaa tgatttagaa aaaaaatata atgctcatat
    10321 tggtgtttat gctttagata ctaaaagtgg taaggaagta aaatttaatt cagataagag
    10381 atttgcctat gcttcgactt caaaagcgat aaatagtgct attttgttag aacaagtacc
    10441 ttataataag ttaaataaaa aagtacatat taacaaagat gatatagttg cttattctcc
    10501 tattttagaa aaatatgtag gaaaagacat cactttaaaa gaacttattg aggcttcaat
    10561 gacatatagt gataatacag caaacaataa aattataaaa gaaatcggtg gaatcaaaaa
    10621 agttaaacaa cgtctaaaag aactaggaga taaagtaaca aatccagtta gatatgagat
    10681 agaattaaat tactattcgc caaagagcaa aaaagatact tcaacgcctg ctgctttcgg
    10741 caagacttta aataaactta tcgcaaatgg aaaattaagc aaaaaaaata aaaatttctt
    10801 acttgattta atgtttaata ataaaaacgg agacacttta attaaagatg gtgttccaaa
    10861 agactataag gttgctgata aaagtggtca agcaataaca tatgcttcta gaaatgatgt
    10921 tgcttttgtt tatcctaagg gccaatctga acctattgtt ttagtcattt ttacgaataa
    10981 agacaataaa agtgataagc caaatgataa gttgataagt gaaaccgcca agagtgtaat
    11041 gaaggaattt taatattcta aatgcataat aaatactgat aacatcttat agtttgtatt
    11101 atattttcta ttatcgttga catgtataat tttgatatca aaacctgatt ttccctttat
    11161 tattttcgag atttattttc ttaattctct ttaacaaact agaaatattg tatatacaaa
    11221 aaatcataaa taatagatga atagtttaat tataggtgtt catcaatcga aaaagcaacg
    11281 tatcttattt aaagtgcgtt gcttttttct catttataag gttaaataat tctcatatat
    11341 caagcaaagt gacataattg ttgaatttat agtaactgaa acgtatgatt agggtgtata
    11401 ttaattatga gatggaaatc aatgattgtt ggctatgcga gagtatcatc gaacgatcaa
    11461 aatttagaaa gacaacttga aaatttaaag acgttttgtg ctgaaaaaat atttacagaa
    11521 aaacagtctg ggaaatctat tgaaaataga ccagtacttc aagaagcact taactttttg
    11581 aggatgggag atcggtttgt agtagaatcc attgattgtt taggtcgtaa ttatgatgaa
    11641 gtggttggca atccattact ggataagttt atgaaagatt taattattca aatattagca
    11701 atggtttcag aacaagagag aaatgaaagt aaacgtcgac aagcgcaagg aattcaagtt
    11761 gcgaaggaaa aaggcgtata taaagggcgc cccttacttt attcaccaaa tgctaaagat
    11821 ccacagaaac gtattattta tcatcgcgtt gtagaaatgt tagaagaagg ccaatcaatt
    11881 agtaaaattg cgaaagaagt aaatataaca aggcagacga tttacagaat taaaaacgat
    11941 aatgatttga tttaataaac tttgtttcaa tgcaactgag agcttctcac agcgtctcaa
    12001 aacagatgat tataatctat tatgagtttt taataataag acaagaaaag agagcgtaaa
    12061 tatgctctct ctttttctca ttaacgaacg tttataacgc aatcatgatg agagtattaa
    12121 tacagttaat tatttgaaat actttagttt atataatgtt gaattatagg tagtgaaatt
    12181 gtatttatta tacattgtca tatcgttgtt taatgatagt taatttaagg ataatagaat
    12241 taatattata tatagatgaa caaaacaagc aacagagcag aaaaaacact tttagattat
    12301 ttttactcat tctctatttt atttattttt gatataataa ataaagaata ttaaatggag
    12361 gtgtttttat gaaaaagaaa tttgtttcta gttgtattgc tagtacaatc ttattcggca
    12421 ctttattagg tgtaacttat aaagctgaag ctgcaacagt acatgtagct ggtggtgttt
    12481 ggagccatgg tattggaaaa cattacgtat ggtcttatta tagtcacaat aaaagaaatc
    12541 atggttcaac agcagtaggg aaatattcat cttttagtgg tgttgctcga cctggtgttc
    12601 aatctaaggc atctgctcca aaggcttggg gtggaaacaa aacattttat agtcttcact
    12661 aattacatat attaattaag gagaatagac agaattaagt aaacttaatt ctgtctattc
    12721 tcttgaaaga ggcaatatga aaaaattcaa attattttta gattttagta ctttattatt
    12781 aatttcaggg ctattatttt tatttttctt caaagaaaat gaagaaatta tacctgaaag
    12841 ttccaatatt ttaacaatct ctaattggga taaatctaac agtaaatcaa aagtgttaga
    12901 tgtcattgaa tcaggcgcca aaaatcaaaa tatacaaata attaaatccg ttaaagattt
    12961 tgataataaa aaagaatttt ttgttttcaa ctcaaaacga aataattctg actttatacg
    13021 taataaaaca tcacttttaa ctccatcaga tttattaaac agagagataa aaggaaagta
    13081 ttatattatt ggtgaacatt tcaatgtaga agagcttacg agtgaattaa aaaaagctgg
    13141 tttaacatct gaagttgaat acataaatag aaacatatta ttttttgaat tagtcataga
    13201 taatgattta ttagtgcctt tcatattctt aggcgtatta tatcttttgt acttcttata
    13261 tgacagagga tataatttga aattttatgc tattcaaaag ctacatggct tttcaactac
    13321 acgcattatt tttcataata ttcatataaa aatcatttat tggctagtac ttaccgctat
    13381 tttctttatt gctaatatat taatcattca tatagccaat ttagaattgg atttcttaat
    13441 gtttattcgt agatttatcg tgttgctttt tgtttttgct tgtattacta cattgctgtg
    13501 gctgatttcg tatagtcttc ttttgaagtt aagtattcca ttaatcttaa aagggaaaaa
    13561 aggatataag ttttcaatat ttatgggtac cttcaccaaa tgtatcatgg tgctaatact
    13621 atctttttta ctggcacaaa atttaaatgc ttatacgaag ttaaagaata tatatgactc
    13681 tgaaaaaatc tggcaaaagt tagataatta ctatacatta gagatttctc ctaatattag
    13741 aaattcagaa gaaaaacaaa ttttagaaac taatatatac aatttaatta agaaaagcga
    13801 acaacttggt ggattgcttt taaagaataa taatatagcc aatcccgata aaaacaatta
    13861 cattcctgaa aatggcaatg tcttttttat caataacaat tttctgaatt tctataaaaa
    13921 tataaatcat gattttaaaa tgattgacaa tcattcggat aaaataaacg tgtttattcc
    13981 tccaaggtta caatatcaaa aatctgaaat tcaaaaaaat caccaaggat ggattgactt
    14041 tcaaaagcaa caaaacaaaa aagtagatgt gcaagtactg tcaaaaaacg tatctgtttt
    14101 ttcttttgat cgcacaacta atttgaaatt tgggtatcta gattctccaa tagtaatgtt
    14161 gttgacactt gacgatttaa caggagattt ttatttagct gctgtttctc aaggtggata
    14221 tctatttaaa gatttagata cacttaaaca gttgcttaaa gataatcacc tagaagaaga
    14281 aattagcggt ataactaatt acaaggattc tgtgttaaat gaattaaatg aaacgaaaac
    14341 aaaaatgata ataacaatag ttactattat tattaacgtt ttcattcttt tgatagctac
    14401 tgtatttgaa acaattcaat attttagctg gaataaaaag caactattat taagaaaaat
    14461 tcatggttat tcattattca gcagtaatgt acgttattta acaatttcta tcttactttc
    14521 tattatgtta gcttacacta cgcatatttt atttggttca aagatattac tattcataat
    14581 aatgtctatt gctattattc aacatttact tcaaattgct tatattaaat atcttgaaaa
    14641 atactttaaa gatttaatga gggagattta aacaatgaaa agaactttaa ttattgtaac
    14701 aattgtacta ttaatcatca tacttagtct gttattggtt agaaatgagc atttagatcg
    14761 ttttaaccca ctgttaaaag aaaaagtatc ttatgccaaa gttccaaaag atacccagga
    14821 ctatagaaat ataactgtat actctaaaaa tggagaaaaa aagagttata aattggattt
    14881 tttaggttat gatcctacaa aagaatatgt gaaagtaaat cataaaggga aatatgtgcg
    14941 ttcgatagaa tacattacaa aagatattcc tagcttttta aaatgaggtg accgatagtg
    15001 ataaaacttg aaaatgtttt tgtaaaaaaa ggtaataaaa acattttaga cggatgtaac
    15061 tttaattttg aaaaaggaaa atcatatgct ttagttggag aaagtggcgc tggaaaatct
    15121 actttactta acataatcgc tgggttcgaa gatgtatcac aaggaagcat atatattgaa
    15181 gataagttac taaaaaagaa agtcgatttt tatagatata cgttagggta tttgtttcaa
    15241 aattttgctt tacttgaaaa tcaaacaatc agtcaaaatt tagatttagc cctaaagttc
    15301 aaaaagaata aaaaagataa tatgaactta aagaaagaag tattaaaaaa ggtcggccta
    15361 gatttagata tcaagagaat tgttagttct ctaagcggtg gtgaacaaca aagagtagca
    15421 ttggcaagat taatattaaa agatccgaaa atcattttag ctgatgaacc tactgggtca
    15481 ctagatacga aaaatggaaa aatagttatt gatttattat tgaagctact tgatgaaaat
    15541 aaaactatga ttgtcgtaac gcatgattta gagcttgcga aacgatttga tgtcatagtc
    15601 aatatttctg agcttagaag ttaagaaata ttgataggta tagccataca tagagaaaaa
    15661 acaatatgaa atatgattag tcattacttt tgagtttttt aatttaagga ctggattttc
    15721 cagtcctttt ttatgatgac aaaaaacaag cctcgcagag cacacgtttt taatgactta
    15781 tttggttttt aataagtcta gtatgttaaa acttttctgt gtttaggtgt tataatcata
    15841 tgcagtggaa gttgatttat tatgtcttat tcaattattc gagttgttaa agtgaaatca
    15901 aaaacaaata caagaggtat tcaaagacat attcaaagag aaaataaaaa ttatgaaaat
    15961 atagatattg atttaagtaa gtcatattta aactatgatt tagtcaatga tactaagttt
    16021 gattttaata aaaaaattga tgagaaaatc gaaaaaaatt ataaagggaa acgcaaaatt
    16081 agaacagatg ccattaaaca tattgatgga ttaattacat cagataatgt gttttttaat
    16141 caattatctg aagaagagac aaaatagttt tttaagcatg ctaaagcgtt cttggaagaa
    16201 gaatacggta aagaaaatct tttatatgcg acagtacata tggatgagat aacaccacat
    16261 atgcattatg gcgtagttcc tattactaaa gatggacgtt taagtgcgaa agaagttgta
    16321 ggtaataaaa aagcattaac cgaattccaa gatagattca atacgtatat taataagcaa
    16381 ggctatgatt taaaacgagg aatttctaga caacttacaa aagaaaaaca tgatcaagtt
    16441 agccgttata aacaaaaaac agaatatcat aaacaaatgc atatgcgcta gaagcaaata
    16501 gaggattatt taaagcaaga aaatgataaa ttgatacaaa actaccaaaa atcattagat
    16561 acgcttaaaa agcttctgag tgtcatgtat gaaattaaaa ctaaaaatgt aggtggatgg
    16621 tttcataaag agaagcaaga aacaggcaat attgtaatta ttaaaactga ttttgaaaaa
    16681 tacactaaac aaattaaagc agcacagatg atattagatg attatgaatg tattaaaagt
    16741 gggaagtcat taaaaaaagc agagaaacaa aatgaaagtt tagttaatga attgactagt
    16801 gtccatatgg aaaatgaaaa gctggttgaa gaatttaatg atttagcaca acgttataat
    16861 tatttgttgt cagagaatga aaagaaagat aaagaactaa attatacgct taagttattc
    16921 aatcaagttt ttaaaatcat taaaagtatg atgaaagaag agcgttatca tacactaata
    16981 aatcatattg ataatcattt agacaattct aaaatacgtg aagtaatgac gatagataac
    17041 aatgatgaac agttctttaa gaagaaatat caagcacaag aacgagaaat catttttaaa
    17101 gaagatagag aagatggtta tacattataa aaatagatat ttaaatgcat ttgtttgagg
    17161 ttaattattt tttaggatga aaaataggta gcccccctcg aactttttaa tatattttta
    17221 taaatctttt taaaaacctt tttaggggct tgttcagccc tagagcaaca agggatttca
    17281 atgcctaaag gagtgttttt gccacataaa aggagtgttt ttgccacata aaaggagtgt
    17341 ttttgccaca taaaaggagt gtttttgcca cataaaagga gtgttttaaa aagttgtact
    17401 ccttttatgg tttgacattg ataataaagt agtttattgt gaataaaagt tttcaaatgg
    17461 gagtgtatat tcaaacgata ctcctttagg ttcgtaataa agggggctgt atcatgacag
    17521 gagagacagt tgtatataaa aatgaaatga atttagttcc attaaggcga tttacagcta
    17581 ctgaaattaa tttatttttt gcgatgtgta ataaattaaa agagcaagat actaatacat
    17641 tacgtttgtc ttttgatgaa ttaaaaaaat taagtaatta tagtccagaa acacgtaata
    17701 ttaatagatt tgctaatgat ttagataatg tgtataaaaa gatgttgaat ttaaccatta
    17761 gatatgaaga tgatgatgta atagaaagat tcgttttatt caatcattat agaatccata
    17821 agcgagaaca atatctagaa atatcaactt cttcaaattt aaaacacata ttgaattcaa
    17881 ttactaataa ttttacaaaa tttgaattaa aagaaatgac taggcttaaa tctacatatt
    17941 ctaaaaatat gtttagatta cttaaacaat acaaacatac aggctattta aaaattcaca
    18001 tcgatgattt taaaaatcgt ttagatatac ctaaatctta tcgtatgact gatattaaca
    18061 aaaatgtttt taaacctatt attattgaat taggttctat atttaataat cttactatca
    18121 ataaaatcaa agcgaaaaaa gggcgtaaaa ttgaatggat agagttcaca tttgacgctg
    18181 agaaacgcat tcataacaaa cgacaacctc aaatgtccaa gatagataaa tcaagacaat
    18241 atgtgaggcg tgaaaagacg cctaaatggt tagaagaacg gtcatatgaa aagcaacctc
    18301 aaaaagatta cgacccacaa ttagagaaag aacgagagga ttttttaaaa caacttgaac
    18361 tgaattggga ataacgcaac ttttcgttgc gagttggtta actaaaagta tcgtgacttt
    18421 tcaattattt taattatagt ttgagttaag gagtgatttt atgaaattag ctgaagctat
    18481 aaaagaacag agagaattaa aaggatggtc tcaagaggaa ttagccaata tattaaaggt
    18541 ttccagacaa agtgtttcta aatgggaaag tgccaaaaac tatccttcct tagatatttt
    18601 gattactatg agcgatttat tcggaatctc tttagagcat ttaattaaag gagatgcacg
    18661 ttttaaaaaa gttattttag agggaaatta tagagagagt aacagggtac cttccatagt
    18721 tgattttctt tatgattttt ggtggctttt ctttcctgtt gccggatttt tagtttgggc
    18781 cattcattcg ttcatgggtt gattttaaaa tcaaaattta atgcacatca ggcaatatga
    18841 aaaaggaaag tatttttacg acaccttgaa atgtattgat aagaatagaa gagtttacaa
    18901 aaggcaatat gaaatatata ctaaaagtaa caagaatttc gtttgtaaac gcaccaaacc
    18961 ccgaactatt cgccgtagtt cggggttttt tggtgaattg gctttaatcg tctatattat
    19021 tttttatcac gtttatggag ctaataacca aataacgtaa cgagacaacc actgattgcc
    19081 gttgtcatga tgtgaacaag aatttcattc ataaatcgca cctcctctct acgccgaatt
    19141 gacatctgag agatagacga ccttcacatt ataacaaatc tctccttcca tgaaataaca
    19201 tgaatattaa taaatgttgt tatatattaa agataaataa atataagggt gggattgata
    19261 atgtttggcg atcaaagaca agaagctaca aaatatgtca ttaaagaagg ttatcaagat
    19321 atttatttcc tcaacaaaaa cggggaatgg tattatttcg aagtaagaag tgtctggcgt
    19381 ggcaaacata ttattagagt taaagatggt ttgttaggtt ggagaaaaga aatagtaact
    19441 gaataaagat acaaaatact tgccaatgca aaagaatgaa aacgcgtcaa atcaacgatg
    19501 tataaaagat gcataaaaga taatgaaagt aaaaagccat aaatgccgtc atataggcat
    19561 ttatggcttt ttgtttggtt aatataatcg atgattatca gaagttcaat tcacataaaa
    19621 aagcacggct aatttatgaa cttgtcgtac ctttttaatt aaaattagtt accaaataga
    19681 cgactccaaa accccttttt agcttccgtt tcttcactct tttcttctat atcactatca
    19741 ttgtcatttg gattagctga aacgtcttct ctttgtgctt cttcaccttg tgtactttcg
    19801 tcgctttgac ttccagatat atccttatat tgaatctctg tttctttagt ttcttcctga
    19861 tctcggttaa tatttacagg actagtagta tatgtttttt cttgtgcatc aacgttttgt
    19921 ctagcgttag tagatgtatc aaagggataa ttaaggtgtt tttctttttc taattgattt
    19981 tctaattttt gaatcttttt attactctct aatgccagaa cttgctgatt ctcaagcaat
    20041 tttgatcttt cttgcaactc ttttctgtaa aattcaattg ttgtttcatg acgactttct
    20101 tgtttttcaa tttgattatt taaagtatta atctgatttt taagtatttc tactatttga
    20161 gcatcgcttt tagattcaaa attaatatta tccgactctt ttttttgttt gtcttcagta
    20221 gcactttcaa aaccatattt ctttttattt tcatttactc tttgaatgat tttttctata
    20281 tcggtatctt ctttaataaa cgaagtgttt tcctgtttta ttgtctctat attcaatctc
    20341 ttaatattat taaaaatcgt ttgcttacta acccctaatt cttcactcaa cctttttaca
    20401 cttttcatat catcaaccct ttataaaatg tttataaacc cttagtaaaa tattataagc
    20461 ttataacgat taataataaa gtaatcgaca aataaaaata taaattcgcc aaccttttta
    20521 tcaagggttt gtaaagggtt tatggtgttt atcaaaggtt tataaaccta tattttccct
    20581 tttttaagtt tattcaaagt gctataataa ccttaatata acaaaaaccc caactactgg
    20641 taatagtcgg ggt
//
