LOCUS       CP126919               20680 bp    DNA     circular BCT 12-JUL-2023
DEFINITION  Staphylococcus aureus strain AUH_SA_2023_5 plasmid unnamed, complete
            sequence.
ACCESSION   CP126919
VERSION     CP126919.1
DBLINK      BioProject: PRJNA961647
            BioSample: SAMN34360576
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 20680)
  AUTHORS   Wollesen,M., Mikkelsen,K., Tvilum,M.S., Vestergaard,M., Wang,M.,
            Meyer,R.L., Ingmer,H., Poulsen,T.B. and Torring,T.
  TITLE     Polyether Ionophore Antibiotics Target Drug-Resistant Clinical
            Isolates, Persister Cells, and Biofilms
  JOURNAL   Microbiol Spectr, e0062523 (2023) In press
   PUBMED   37289074
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 20680)
  AUTHORS   Thorup,C. and Wang,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-APR-2023) Bioscience, Aarhus University, Ny Munkegade
            114, Aarhus C 8000, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.9.2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 414x
            Sequencing Technology             :: Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 06/02/2023 16:58:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.5
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,820
            CDSs (total)                      :: 2,739
            Genes (coding)                    :: 1,912
            CDSs (with protein)               :: 1,912
            Genes (RNA)                       :: 81
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 827
            CDSs (without protein)            :: 827
            Pseudo Genes (ambiguous residues) :: 0 of 827
            Pseudo Genes (frameshifted)       :: 800 of 827
            Pseudo Genes (incomplete)         :: 42 of 827
            Pseudo Genes (internal stop)      :: 16 of 827
            Pseudo Genes (multiple problems)  :: 28 of 827
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..20680
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="AUH_SA_2023_5"
                     /isolation_source="The strain was isolated from blood
                     culture"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="unnamed"
                     /geo_loc_name="Denmark: Aarhus"
                     /lat_lon="56.19 N 10.17 E"
                     /collection_date="2023"
                     /collected_by="Aarhus University Hospital"
     gene            join(20207..20680,1..60)
                     /locus_tag="QQG21_00005"
     CDS             join(20207..20680,1..60)
                     /locus_tag="QQG21_00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002436987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WKD07100.1"
                     /translation="MIVGYARVSSNDQNLERQLENLKTFCAEKIFTEKQSGKSIENRPV
                     LQEALNFLRMGDRFVVESIDCLGRNYDEVVGNPLLDKFMKDLIIQILAMVSEQERNESK
                     RRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRIIYHRVVEMLEEGQSISKIAKEVNIT
                     RQTIYRIKNDNDLI"
                     /name="recombinase family protein"
     gene            474..767
                     /locus_tag="QQG21_00010"
     CDS             474..767
                     /locus_tag="QQG21_00010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WKD07101.1"
                     /translation="MKKKFVSSCIASTILFGTLLGVTYKAEAATVHVAGGVWSHGIGKH
                     YVWSYYSHNKRNHGSTAVGKYSSFSGVARPGVQSKASAPKAWGGNKTFYSLH"
                     /name="lactococcin 972 family bacteriocin"
     gene            842..1111
                     /locus_tag="QQG21_00015"
     CDS             842..1111
                     /locus_tag="QQG21_00015"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WKD07102.1"
                     /translation="MKKFKLFLDFSTLLLISGLLFLFFFKENEEIIPESSNILTISNWD
                     KSNSKSKVLDVIESGAKNQNIQIIKSVKDFDNKKRIFCFQLKTK"
                     /name="hypothetical protein"
     gene            1065..1784
                     /locus_tag="QQG21_00020"
     CDS             1065..1784
                     /locus_tag="QQG21_00020"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WKD07103.1"
                     /translation="MIIKKEFFVFNSKRNNSDFIRNKTSLLTPSDLLNREIKGKYYIIG
                     EHFNVEELTSELKKAGLTSEVEYINRNILFFELVIDNDLLVPFIFLGVLYLLYFLYDRG
                     YNLKFYAIQKLHGFSTTRIIFHNIHIKIIYWLVLTAIFFIANILIIHIANLELDFLMFI
                     RRFIVLLFVFACITTLLWLISYSLLLKLSIPLILKGKKGYKFSIFMGTFTKCIMVLILS
                     FFTGTKFKCLYEVKEYI"
                     /name="hypothetical protein"
     gene            1979..2779
                     /locus_tag="QQG21_00025"
     CDS             1979..2779
                     /locus_tag="QQG21_00025"
                     /inference="COORDINATES: protein motif:HMM:NF018897.2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1430 domain-containing protein"
                     /protein_id="WKD07104.1"
                     /translation="MAMSFFINNNFLNFYKNINHDFKMIDNHSDKINVFIPPRLQYQKS
                     EIQKNHQGWIDFQKQQNKKVDVQVLSKNVSVFSFDRTTNLKFGYLDSPIVMLLTLDDLT
                     GDFYLAAVSQGGYLFKDLDTLKQLLKDNHLEEEISGITNYKDSVLNELNETKTKMIITI
                     VTIIINVFILLIATVFETIQYFSWNKKQLLLRKIHGYSLFSSNVRYLTISILLSIMLAY
                     TTHILFGSKILLFIIMSIAIIQHLLQIAYIKYLEKYFKDLMREI"
                     /name="DUF1430 domain-containing protein"
     gene            2783..3094
                     /locus_tag="QQG21_00030"
     CDS             2783..3094
                     /locus_tag="QQG21_00030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YxeA family protein"
                     /protein_id="WKD07105.1"
                     /translation="MKRTLIIVTIVLLIIILSLLLVRNEHLDRFNPLLKEKVSYAKVPK
                     DTQDYRNITVYSKNGEKKSYKLDFLGYDPTKEYVKVNHKGKYVRSIEYITKDIPSFLK"
                     /name="YxeA family protein"
     gene            3106..3733
                     /locus_tag="QQG21_00035"
                     /pseudo=""
     CDS             3106..3733
                     /locus_tag="QQG21_00035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593102.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /name="ABC transporter ATP-binding protein"
     gene            3972..4466
                     /gene="mobV"
                     /locus_tag="QQG21_00040"
                     /pseudo=""
     CDS             3972..4466
                     /gene="mobV"
                     /locus_tag="QQG21_00040"
                     /inference="COORDINATES: protein motif:HMM:NF013258.2"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MobV family relaxase"
                     /name="mobV"
     gene            4480..4602
                     /locus_tag="QQG21_00045"
     CDS             4480..4602
                     /locus_tag="QQG21_00045"
                     /inference="COORDINATES: protein motif:HMM:NF013258.2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WKD07110.1"
                     /translation="MNKQGYDLKRGISRQLTKEKHDQVSRYKQKTEYHKQMHMR"
                     /name="hypothetical protein"
     gene            4696..5241
                     /locus_tag="QQG21_00050"
     CDS             4696..5241
                     /locus_tag="QQG21_00050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001805533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase"
                     /protein_id="WKD07106.1"
                     /translation="MYEIKTKNVGGWFHKEKQETGNIVITKTDFEKYTKQIKAAQMILD
                     DYECIKSGKSLKKAEKQNESLVNELTSVHMENEKLVEEFNDLAQRYNYLLSENEKKDKE
                     LNYTLKLFNQVFKIIKSMMKEERYHTLINHIDNHLDNSKIREVMTIDNNDEQFFKKKYQ
                     AQEREIIFKEDREDGYTL"
                     /name="recombinase"
     gene            complement(5272..5568)
                     /locus_tag="QQG21_00055"
     CDS             complement(5272..5568)
                     /locus_tag="QQG21_00055"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WKD07107.1"
                     /translation="MKTFIHNKLLYYQCQTIKGVQLFKTLLLCGKNTPFMWQKHSFYVA
                     KTLLLCGKNTPLGIEIPCCSRAEQAPKKVFKKIYKNILKSSRGGYLFFILKNN"
                     /name="hypothetical protein"
     gene            5626..6488
                     /locus_tag="QQG21_00060"
                     /pseudo=""
     CDS             5626..6488
                     /locus_tag="QQG21_00060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            6575..6916
                     /locus_tag="QQG21_00065"
     CDS             6575..6916
                     /locus_tag="QQG21_00065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WKD07108.1"
                     /translation="MKLAEAIKEQRELKGWSQEELANILKVSRQSVSKWESAKNYPSLD
                     ILIAMSDLFGISLEHLIKGDARFKKVILEGNYRESNRVPSIVDFLYDFWWLFFPVAGFL
                     VWAIHSFMG"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(7156..7227)
                     /locus_tag="QQG21_00070"
     CDS             complement(7156..7227)
                     /locus_tag="QQG21_00070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WKD07111.1"
                     /translation="MNEILVHIMTTAISGCLVTLFGY"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            7376..7561
                     /locus_tag="QQG21_00075"
     CDS             7376..7561
                     /locus_tag="QQG21_00075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WKD07109.1"
                     /translation="MFGDQRQEATKYVIKEGYQDIYFLNKNGEWYYFEVRSVWRGKHII
                     RVKDGLLGWRKEIVTE"
                     /name="hypothetical protein"
     gene            complement(7782..8508)
                     /locus_tag="QQG21_00080"
                     /pseudo=""
     CDS             complement(7782..8508)
                     /locus_tag="QQG21_00080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002487376.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /name="DUF536 domain-containing protein"
     gene            8939..9615
                     /locus_tag="QQG21_00085"
                     /pseudo=""
     CDS             8939..9615
                     /locus_tag="QQG21_00085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /name="replication initiator protein A"
     gene            9626..9908
                     /locus_tag="QQG21_00090"
                     /pseudo=""
     CDS             9626..9908
                     /locus_tag="QQG21_00090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199895.1"
                     /note="frameshifted; internal stop; incomplete; partial on
                     complete genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology. GO_function: GO:0003677 - DNA binding
                     [Evidence IEA]; GO_process: GO:0006260 - DNA replication
                     [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            11122..11739
                     /gene="cadD"
                     /locus_tag="QQG21_00095"
     ARG             11123..11736
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="99.51"
                     /coverage="100.0"
     gene            11758..12105
                     /locus_tag="QQG21_00100"
     CDS             11758..12105
                     /locus_tag="QQG21_00100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]; GO_process: GO:0006355 - regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WKD07094.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNQEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            12274..12366
                     /locus_tag="QQG21_00105"
     CDS             12274..12366
                     /locus_tag="QQG21_00105"
                     /inference="COORDINATES: protein motif:HMM:NF033608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WKD07095.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            12579..13103
                     /locus_tag="QQG21_00110"
     CDS             12579..13103
                     /locus_tag="QQG21_00110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4062 domain-containing protein"
                     /protein_id="WKD07096.1"
                     /translation="MSNTKIKYQIFISSTYLDLIEERQAVVEAVLNSNNIPAGMELFNS
                     SSKSQWEIITQWINESDAVILLLGSSYGTIDSEENISYTEMEYNFAKSLGKPIYVFEMN
                     KASTESAEKSKKLDEFKTKVKENRLISPNINDISELKSKVSQTLMQSVPSEIKENSGWI
                     RVQDCGKNVKK"
                     /name="DUF4062 domain-containing protein"
     gene            13148..13438
                     /locus_tag="QQG21_00115"
     CDS             13148..13438
                     /locus_tag="QQG21_00115"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WKD07097.1"
                     /translation="MKEELYKIFMYVKTFYFQHTPFDDSYIEDIENYLLNYENNPHKSF
                     MKIKVYDYKNFLKHLKNILILIKQGKKPLAQAGHFKLSFYEEDLKLLQKKL"
                     /name="hypothetical protein"
     gene            complement(13673..14488)
                     /locus_tag="QQG21_00120"
     CDS             complement(13673..14488)
                     /locus_tag="QQG21_00120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019467708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WKD07098.1"
                     /translation="MTKNQNFIETKEYKRFAEFCDACIKYQYIGICYGQPGVGKTLSSR
                     YYTNWDTIEKQVNHRGWEDLASKTTDDILSVDKIFYNAPAEKQTKLRNDLYSITAIIDL
                     GQKLHVVNKYGHEHSKHYSDMFKYIDLIIVDEIDRLKVQHLEQLRAIYDEHNLAMIFIG
                     MPGIEKKLSRYPQLYSRIGFAHEFDNLSKDETHHILEYKWQDLGFDLKLEDFTDYEAIT
                     TIIKITKGNFRLIHRLFAQIDRIMDINGLDKISTEVVETARDSLVIGIR"
                     /name="AAA family ATPase"
     gene            complement(14481..15926)
                     /locus_tag="QQG21_00125"
                     /pseudo=""
     CDS             complement(14481..15926)
                     /locus_tag="QQG21_00125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790716.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_process: GO:0015074 - DNA integration [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DDE-type integrase/transposase/recombinase"
                     /name="DDE-type integrase/transposase/recombinase"
     gene            complement(15898..16491)
                     /locus_tag="QQG21_00130"
     CDS             complement(15898..16491)
                     /locus_tag="QQG21_00130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000150 - DNA strand exchange activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WKD07099.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNQKDLNLLKTLYDNGTPI
                     KTIAEQWHVSRTTIYRYLNKLEDKEDEKQGEVSN"
                     /name="recombinase family protein"
     gene            complement(16755..17136)
                     /gene="blaI"
                     /locus_tag="QQG21_00135"
                     /pseudo=""
     CDS             complement(16755..17136)
                     /gene="blaI"
                     /locus_tag="QQG21_00135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284656.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_process: GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="penicillinase repressor BlaI"
                     /name="blaI"
     gene            complement(17126..18885)
                     /gene="blaR1"
                     /locus_tag="QQG21_00140"
                     /pseudo=""
     CDS             complement(17126..18885)
                     /gene="blaR1"
                     /locus_tag="QQG21_00140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096376.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="beta-lactam sensor/signal transducer BlaR1"
                     /name="blaR1"
     gene            18992..19838
                     /gene="blaZ"
                     /locus_tag="QQG21_00145"
                     /pseudo=""
     CDS             18992..19838
                     /gene="blaZ"
                     /locus_tag="QQG21_00145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000733274.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /name="blaZ"
     ARG             19597..19838
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="97.5"
                     /coverage="28.47"
     BGC             1..5767
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          9968..10116
                     /name="MOBV"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="80.795"
                     /coverage="100.0"
                     /evalue="1.3799999999999998e-23"
     Typing          5627..6488
                     /name="rep_cluster_2214"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.768"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(7783..8527)
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.732"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          3973..4247
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="94.565"
                     /coverage="100.0"
                     /evalue="4.71e-46"
ORIGIN
        1 gaagtaaata taacaaggca gacgatttac agaattaaaa acgataatga tttgatttaa
       61 taaactttgt ttcaatgcaa ctgagagctt ctcacagcgt ctcaaaacag atgattataa
      121 tctattatga gtttttaata ataagacaag aaaagagagc gtaaatatgc tctctctttt
      181 tctcattaac gaacgtttat aacgcaatca tgatgagagt attaatacag ttaattattt
      241 gaaatacttt agtttatata atgttgaatt ataggtagtg aaattgtatt tattatacat
      301 tgtcatatcg ttgtttaatg atagttaatt taaggataat agaattaata ttatatatag
      361 atgaacaaaa caagcaacag agcagaaaaa acacttttag attattttta ctcattctct
      421 attttattta tttttgctat aataaataaa taatattaaa tggaggtgtt tttatgaaaa
      481 agaaatttgt ttctagttgt attgctagta caatcttatt cggcacttta ttaggtgtaa
      541 cttataaagc tgaagctgca acagtacatg tagctggtgg tgtttggagc catggtattg
      601 gaaaacatta cgtatggtct tattatagtc acaataaaag aaatcatggt tcaacagcag
      661 tagggaaata ttcatctttt agtggtgttg ctcgacctgg tgttcaatct aaggcatctg
      721 ctccaaaggc ttggggtgga aacaaaacat tttatagtct tcactaatta catatattaa
      781 ttaaggagaa tagacagaat taagtaaact taattctgtc tattctcttg aaagaggcaa
      841 tatgaaaaaa ttcaaattat ttttagattt tagtacttta ttattaattt cagggctatt
      901 atttttattt ttcttcaaag aaaatgaaga aattatacct gaaagttcca atattttaac
      961 aatctctaat tgggataaat ctaacagtaa atcaaaagtg ttagatgtca ttgaatcagg
     1021 cgccaaaaat caaaatatac aaataattaa atccgttaaa gattttgata ataaaaaaag
     1081 aattttttgt tttcaactca aaacgaaata attctgactt tatacgtaat aaaacatcac
     1141 ttttaactcc atcagattta ttaaacagag agataaaagg aaagtattat attattggtg
     1201 aacatttcaa tgtagaagag cttacgagtg aattaaaaaa agctggttta acatctgaag
     1261 ttgaatacat aaatagaaac atattatttt ttgaattagt catagataat gatttattag
     1321 tgcctttcat attcttaggc gtattatatc ttttgtactt cttatatgac agaggatata
     1381 atttgaaatt ttatgctatt caaaagctac atggcttttc aactacacgc attatttttc
     1441 ataatattca tataaaaatc atttattggc tagtacttac cgctattttc tttattgcta
     1501 atatattaat cattcatata gccaatttag aattggattt cttaatgttt attcgtagat
     1561 ttatcgtgtt gctttttgtt tttgcttgta ttactacatt gctgtggctg atttcgtata
     1621 gtcttctttt gaagttaagt attccattaa tcttaaaagg gaaaaaagga tataagtttt
     1681 caatatttat gggtaccttc accaaatgta tcatggtgct aatactatct ttttttactg
     1741 gcacaaaatt taaatgctta tacgaagtta aagaatatat atgactctga aaaaatctgg
     1801 caaaagttag ataattacta tacattagag atttctccta atattagaaa ttcagaagaa
     1861 aaacaaattt tagaaactaa tatatacaat ttaattaaga aaagcgaaca acttggtgga
     1921 ttgcttttaa agaataataa tatagccaat cccgataaaa acaattacat tcctgaaaat
     1981 ggcaatgtct ttttttatca ataacaattt tctgaatttc tataaaaata taaatcatga
     2041 ttttaaaatg attgacaatc attcggataa aataaacgtg tttattcctc caaggttaca
     2101 atatcaaaaa tctgaaattc aaaaaaatca ccaaggatgg attgactttc aaaagcaaca
     2161 aaacaaaaaa gtagatgtgc aagtactgtc aaaaaacgta tctgtttttt cttttgatcg
     2221 cacaactaat ttgaaatttg ggtatctaga ttctccaata gtaatgttgt tgacacttga
     2281 cgatttaaca ggagattttt atttagctgc tgtttctcaa ggtggatatc tatttaaaga
     2341 tttagataca cttaaacagt tgcttaaaga taatcaccta gaagaagaaa ttagcggtat
     2401 aactaattac aaggattctg tgttaaatga attaaatgaa acgaaaacaa aaatgataat
     2461 aacaatagtt actattatta ttaacgtttt cattcttttg atagctactg tatttgaaac
     2521 aattcaatat tttagctgga ataaaaagca actattatta agaaaaattc atggttattc
     2581 attattcagc agtaatgtac gttatttaac aatttctatc ttactttcta ttatgttagc
     2641 ttacactacg catattttat ttggttcaaa gatattacta ttcataataa tgtctattgc
     2701 tattattcaa catttacttc aaattgctta tattaaatat cttgaaaaat actttaaaga
     2761 tttaatgagg gagatttaaa caatgaaaag aactttaatt attgtaacaa ttgtactatt
     2821 aatcatcata cttagtctgt tattggttag aaatgagcat ttagatcgtt ttaacccact
     2881 gttaaaagaa aaagtatctt atgccaaagt tccaaaagat acccaggact atagaaatat
     2941 aactgtatac tctaaaaatg gagaaaaaaa gagttataaa ttggattttt taggttatga
     3001 tcctacaaaa gaatatgtga aagtaaatca taaagggaaa tatgtgcgtt cgatagaata
     3061 cattacaaaa gatattccta gctttttaaa atgaggtgac cgatagtgat aaaacttgaa
     3121 aatgtttttg taaaaaaaag gtaataaaaa cattttagac ggatgtaact ttaattttga
     3181 aaaaggaaaa tcatatgctt tagttggaga aagtggcgct ggaaaatcta ctttacttaa
     3241 cataatcgct gggttcgaag atgtatcaca aggaagcata tatattgaag ataagttact
     3301 aaaaaagaaa gtcgattttt atagatatac gttagggtat ttgtttcaaa attttgcttt
     3361 acttgaaaat caaacaatca gtcaaaattt agatttagcc ctaaagttca aaaagaataa
     3421 aaaagataat atgaacttaa agaaagaagt attaaaaaag gtcggcctag atttagatat
     3481 caagagaatt gttagttctc taagcggtgg tgaacaacaa agagtagcat tggcaagatt
     3541 aatattaaaa gatccgaaaa tcattttagc tgatgaacct actgggtcac tagatacgaa
     3601 aaatggaaaa atagttattg atttattatt gaagctactt gatgaaaata aaactatgat
     3661 tgtcgtaacg catgatttag agcttgcgaa acgatttgat gtcatagtca atatttctga
     3721 gcttagaagt taagaaatat tgataggtat agccatacat agagaaaaaa caatatgaaa
     3781 tatgattagt cattactttt gagtttttta atttaaggac tggattttcc agtccttttt
     3841 ttatgatgat aaaaaacaag cctcgcagag cacacgtttt taatgactta tttggttttt
     3901 aataagtcta gtatgttaaa acttttctgt gtttaggtgt tataatcata tgcagtggaa
     3961 gttgatttat tatgtcttat tcaattattc gagttgttaa agtgaaatca aaaacaaata
     4021 caagaggtat tcaaagacat attcaaagag aaaataaaaa ttatgaaaat atagatattg
     4081 atttaagtaa gtcatattta aactatgatt tagtcaatga tactaagttt gattttaata
     4141 aaaaaattga tgagaaaatc gaaaaaaatt ataaagggaa acgcaaaatt agaacagatg
     4201 ccattaaaca tattgatgga ttaattacat cagataatgt gttttttaat caattatctg
     4261 aagaagagac aaaatagttt tttaagcatg ctaaagcgtt cttggaagaa gaatacggta
     4321 aagaaaatct tttatatgcg acagtacata tggatgagat aacaccacat atgcattatg
     4381 gcgtagttcc tattactaaa gatggacgtt taagtgcgaa agaagttgta ggtaataaaa
     4441 aaagcattaa ccgaattcca agatagattc aatacgtata ttaataagca aggctatgat
     4501 ttaaaacgag gaatttctag acaacttaca aaagaaaaac atgatcaagt tagccgttat
     4561 aaacaaaaaa cagaatatca taaacaaatg catatgcgct agaagcaaat agaggattat
     4621 ttaaagcaag aaaatgataa attgatacaa aactaccaaa aatcattaga tacgcttaaa
     4681 aagcttctga gtgtcatgta tgaaattaaa actaaaaatg taggtggatg gtttcataaa
     4741 gagaagcaag aaacaggcaa tattgtaatt actaaaactg attttgaaaa atacactaaa
     4801 caaattaaag cagcacagat gatattagat gattatgaat gtattaaaag tgggaagtca
     4861 ttaaaaaaag cagagaaaca aaatgaaagt ttagttaatg aattgactag tgtccatatg
     4921 gaaaatgaaa agctggttga agaatttaat gatttagcac aacgttataa ttatttgttg
     4981 tcagagaatg aaaagaaaga taaagaacta aattatacgc ttaagttatt caatcaagtt
     5041 tttaaaatca ttaaaagtat gatgaaagaa gagcgttatc atacactaat aaatcatatt
     5101 gataatcatt tagacaattc taaaatacgt gaagtaatga cgatagataa caatgatgaa
     5161 cagttcttta agaagaaata tcaagcacaa gaacgagaaa tcatttttaa agaagataga
     5221 gaagatggtt atacattata aaaatagata tttaaatgca tttgtttgag gttaattatt
     5281 ttttaggatg aaaaataggt agccccccct cgaacttttt aatatatttt tataaatctt
     5341 tttaaaaacc tttttagggg cttgttcagc cctagagcaa caagggattt caatgcctaa
     5401 aggagtgttt ttgccacata aaaggagtgt ttttgccaca taaaaggagt gtttttgcca
     5461 cataaaagga gtgtttttgc cacataaaag gagtgtttta aaaagttgta ctccttttat
     5521 ggtttgacat tgataataaa gtagtttatt gtgaataaaa gttttcaaat gggagtgtat
     5581 attcaaacga tactccttta ggttcgtaat aaagggggct gtatcatgac aggagagaca
     5641 gttgtatata aaaatgaaat gaatttagtt ccattaaggc gatttacagc tactgaaatt
     5701 aatttatttt ttgcgatgtg taataaatta aaagagcaag atactaatac attacgtttg
     5761 tcttttgatg aattaaaaaa aattaagtaa ttatagtcca gaaacacgta atattaatag
     5821 atttgctaat gatttagata atgtgtataa aaagatgttg aatttaacca ttagatatga
     5881 agatgatgat gtaatagaaa gattcgtttt attcaatcat tatagaatcc ataagcgaga
     5941 acaatatcta gaaatatcaa cttcttcaaa tttaaaacac atattgaatt caattactaa
     6001 taattttaca aaatttgaat taaaagaaat gactaggctt aaatctacat attctaaaaa
     6061 tatgtttaga ttacttaaac aatacaaaca tacaggctat ttaaaaattc acatcgatga
     6121 ttttaaaaat cgtttagata tacctaaatc ttatcgtatg actgatatta acaaaaatgt
     6181 ttttaaacct attattattg aattaggttc tatatttaat aatcttacta tcaataaaat
     6241 caaagcgaaa aaagggcgta aaattgaatg gatagagttc acatttgacg ctgagaaacg
     6301 cattcataac aaacgacaac ctcaaatgtc caagatagat aaatcaagac aatatgtgag
     6361 gcgtgaaaag acgcctaaat ggttagaaga acggtcatat gaaaagcaac ctcaaaaaag
     6421 attacgaccc acaattagag aaagaacgag aggatttttt aaaacaactt gaactgaatt
     6481 gggaataacg caacttttcg ttgcgagttg gttaactaaa agtatcgtga cttttcaatt
     6541 attttaatta tagtttgagt taaggagtga ttttatgaaa ttagctgaag ctataaaaga
     6601 acagagagaa ttaaaaggat ggtctcaaga ggaattagcc aatatattaa aggtttccag
     6661 acaaagtgtt tctaaatggg aaagtgccaa aaactatcct tccttagata ttttgattgc
     6721 tatgagcgat ttattcggaa tctctttaga gcatttaatt aaaggagatg cacgttttaa
     6781 aaaagttatt ttagagggaa attatagaga gagtaacagg gtaccttcca tagttgattt
     6841 tctttatgat ttttggtggc ttttctttcc tgttgccgga tttttagttt gggccattca
     6901 ttcgttcatg ggttgatttt aaaatcaaaa tttaatgcac atcaggcaat atgaaaaagg
     6961 aaagtatttt tacgacacct tgaaatgtat tgataagaat agaagagttt acaaaaggca
     7021 atatgaaata tatactaaaa gtaacaagaa tttcgtttgt aaacgcacca aaccccgaac
     7081 tattcgccgt agttcggggt ttttttggtg aattggcttt aatcgtctat attatttttt
     7141 atcacgttta tggagctaat aaccaaataa cgtaacgaga caaccactga ttgccgttgt
     7201 catgatgtga acaagaattt cattcataaa tcgcacctcc tctctacgcc gaattgacat
     7261 ctgagagata gacgaccttc acattataac aaatctctcc ttccatgaaa taacatgaat
     7321 attaataaat gttgttatat attaaagata aataaatata agggtgggat tgataatgtt
     7381 tggcgatcaa agacaagaag ctacaaaata tgtcattaaa gaaggttatc aagatattta
     7441 tttcctcaac aaaaacgggg aatggtatta tttcgaagta agaagtgtct ggcgtggcaa
     7501 acatattatt agagttaaag atggtttgtt aggttggaga aaagaaatag taactgaata
     7561 aagatacaaa atacttgcca atgcaaaaga atgaaaacgc gtcaaatcaa cgatgtataa
     7621 aagatgcata aaagataatg aaagtaaaaa agccataaat gcctatatga cggcatttat
     7681 ggcttttttg tttggttaat ataatcgatg attatcagaa gttcaattca cataaaaaag
     7741 cacggctaat ttatgaactt gtcgtacctt tttaattaaa attagttacc aaatagacga
     7801 ctccaaaacc cctttttagc ttccgtttct tcactctttt cttctatatc actatcattg
     7861 tcatttggat tagctgaaac gtcttctctt tgtgcttctt caccttgtgt actttcgtcg
     7921 ctttgacttc cagatatatc cttatattga atctctgttt ctttagtttc ttcctgatct
     7981 cggttaatat ttacaggact agtagtatat gttttttctt gtgcatcaac gttttgtcta
     8041 gcgttagtag atgtatcaaa gggataatta aggtgttttt ctttttctaa ttgattttct
     8101 aatttttgaa tcttttttat tactctctaa tgccagaact tgctgattct caagcaattt
     8161 tgatctttct tgcaactctt ttctgtaaaa ttcaattgtt gtttcatgac gactttcttg
     8221 tttttcaatt tgattattta aagtattaat ctgattttta agtatttcta ctatttgagc
     8281 atcgctttta gattcaaaat taatattatc cgactctttt ttttgtttgt cttcagtagc
     8341 actttcaaaa ccatatttct ttttattttc atttactctt tgaatgattt tttctatatc
     8401 ggtatcttct ttaataaacg aagtgttttc ctgttttatt gtctctatat tcaatctctt
     8461 aatattatta aaaatcgttt gcttactaac ccctaattct tcactcaacc ttttttacac
     8521 ttttcatatc atcaaccctt tataaaatgt ttataaaccc ttagtaaaat attataagct
     8581 tataacgatt aataataaag taatcgacaa ataaaaatat aaattcgcca acctttttat
     8641 caagggtttg taaagggttt atggtgttta tcaaaggttt ataaacctat atttttcctt
     8701 tttttaagtt tattcaaagt gctataataa ccttaatata acaaaaaccc caactactgg
     8761 taatagtcgg ggtttggtaa taaaacgttt agaaactgtt tatttatata attttcgata
     8821 cttagattat ataatgaata atatcttagt gcaagcacct agattattaa ataaacacaa
     8881 aaaatgtaag cgttttatta cctcttacca aactaaaatt cggaaagagg tttttattat
     8941 gtcaattaaa ctttacaaca taaatgagga atacagagaa aagttttatc aaataccgaa
     9001 agtatttttt acaaatccta aatatatcaa gttatccaat gatgcaaaaa tggcatgggg
     9061 tattcttaga gatcgtttag atttatcaat taaaaatggt tgggttgatt ctaaaacagg
     9121 taatatttat ttttattaca aaaatgaaaa cccacaaaat atattaaatt gtaaaaaaga
     9181 taaagtaatt aaaataaaga aagaacttaa ttgaagccga attactacta caagaaagac
     9241 aaggtttaaa taagacaaat aaactttatt tagttaaacc agaagtaaca gaagatgata
     9301 tttataaaat tcaaaagcaa gaaaacactg ttgagagcag caatggcaag gaagtcggaa
     9361 aaaccgactt caagaagtcg ataaaacaga atctaatgat actgaactta gctatactga
     9421 atctaacaat actgaaataa atgatatgaa tgacttgaat gatatagagt ccgaaaatga
     9481 aattagtaat cattcaagtc aatgcaaggt tatttaatgc aaacaatttt aactgaattt
     9541 gaagaaacac atgcacttta tatgcgccgt aaaaacatga aacaatataa tatctttaat
     9601 caatcattca aatgatttta taacaatcaa agatacatca aaatatttcg ttaaatcatc
     9661 tgacttttta actgatagcg atgaaaaaat caagaaattg tcagtgatct agaaaaagat
     9721 ttgtatcgaa aacgtatgtt aagttatggt ggattgctta aataaaaaca taaaatttta
     9781 aacttagacg atgctgaaga tggcaattta attaatacaa gtgatgaaga taaaatagca
     9841 aatgaagaag aaaaggcaca ttcgattacg gcaattttga aaagcaaaat tattatttaa
     9901 ggcattagtg ataactgatg tcttttttta ttactttttt tgtaaaaaaa agtgctgtct
     9961 tatttttgtg acaaatgctg tatgtagtgt cacaaaagtg tgacacttga gctttttatg
    10021 accccacaca aaaacatttt cgaagccttg aaatatctgg ctttgccaga tccccccatt
    10081 cattgatggg gacaaatttc ccttatgctc ttacggagat tttagagtta aattaaaatt
    10141 tctaagtttt tgataagaaa agccctgcag gaatttagaa gaacgtgggg aagttttaaa
    10201 gaattttatg ctaattttta atttgcatgt aaatgggcag tgtctaaaaa atagttattg
    10261 tttttgctca aatttttgtt tttgaaaata gcatatattt atttggctca tatttgcgtt
    10321 ttaaaagcgt atataagttt tagataaaac tatatgaatc acccctaaat ctttaaaatg
    10381 ccctcttaaa attcaaaata agggcataaa aaataaaagc cccccccaga taaagtgagg
    10441 tagctttttc tttcgacgcc gtatcgtcga tgtaattcaa aaaaagttat gggctataaa
    10501 tctacatcac tttttcaaga atgtagtagc aatattcaac gcaaattaat ttttataact
    10561 gctcggaata tctcaagccg tttctttaat tttgaaataa aaaaatcgac gaaggtcgat
    10621 tacgtttttg cacatgtcga tttatccgac gtataagtgc gcccttacgg gatttaacta
    10681 gattataacg acgaatttta gacctgtaaa gcaataacaa ttaggtctac caggtagata
    10741 aagtgtacaa agtagaaccg aaaaagttat ttattttgaa gatttttcgt agatataatt
    10801 tgctaataaa cttcctaaaa ctgaataaag aaaaatagtt aaactcatgt aatcactcca
    10861 taattctgaa gtgtctccat gtctacgcat agacacgcat ttatgccgag aaaatttatt
    10921 gtgcgttgag aagaaccctt aactaaactt gcagacgaat gtcggcatag cgtgagctat
    10981 taagccgacc attcgacaag ttttgggatt gttaagggtt ccgaggctca acgtcaataa
    11041 agcaattgga ataaagcacc tatgattatt taaaaatata agttataata cattcaaaaa
    11101 tatttttgaa tgaggtgtat tatgattcaa acggttgttg ctgctgctgt tctttatatt
    11161 gctacagcag ttgatttatt agtaatttta ttaatatttt ttgctagagc aaagactaga
    11221 aaagaatata gaaatattta tgttggtcaa tatttagggt ctattatttt aatattagtt
    11281 agtttgtttt tagcttttgt attaaattat gttccagaaa agtggatatt aggtttattg
    11341 ggtttaatac caatttatct tggaattaaa gtggctattt atgatgattg tgaaggagaa
    11401 aagagagcta aaaaagaatt gaatgaaaaa ggattgtcta aattagttgg tacggttgca
    11461 attgttacga tagcaagttg tggcgccgat aatattggtt tatttgttcc ttattttgtg
    11521 acattaagtg ttactaattt attacttact ctgtttgtct ttttaatttt aattttcttc
    11581 ttggtgttta ctgcacaaaa attagctaat atcccaggaa ttggagaaat tgttgagaaa
    11641 tttagtcgtt ggattatggc tatcatttat atagctttag gtttatttat tattattgaa
    11701 aatgacacta ttcaaacaat tttaggattt atattttaat ttagggtgtg attttatatg
    11761 agttatgaaa atacttgtga tgtgatctgt gtacatgagg ataaagttaa caatgcttta
    11821 agttttttag aagatgataa atctaagaaa ttacttaaca ttttagaaaa aatttgtgat
    11881 gagaagaaat tgaaaatcat attatctttg attaaagaag atgagttgtg tgtttgtgat
    11941 atttctttga tattgaaaat gagtgttgct tcaacttcac atcatttaag gcttttatat
    12001 aaaaatgagg tacttgattt ttataaagat ggaaagatgg catattattt tattaaagac
    12061 gatgaaataa gagagttttt ctctaaaaat caggagggtt tttgaaacga gtgaaacgag
    12121 tttcttcttg tcttgatact ataaaaaaca aagttatata acataagacg acttatcgga
    12181 agttatctat catcgtatat tcggagatga tataatatac aggtcgccta tctctcaggc
    12241 gtcaattcag acgcagagag gaggtgcatt actttgctaa tcattttcgt tcacatcata
    12301 gcaccagtca tcagtggctg tgctgttgcg tattatactt attggcttag taaacgcaac
    12361 aaataattaa taggcgactt tataagccag catcgaaaaa atccccacac tattgcagta
    12421 gtgtggggat tggtgcatta attgttaatc attttcgtta tctagattat aacactggtt
    12481 agtagaggaa tgcaaaaaga taatatttta agtagtcttt tttggatatt atcatatgat
    12541 atatttatgt aaattgattt tttattaaag gagcatatat gagtaatact aaaattaaat
    12601 atcaaatttt tatttcatca acttatttag atttaataga agagcgtcaa gcagtagtag
    12661 aagcagtttt aaacagtaat aatattccag caggtatgga actttttaac tcaagtagta
    12721 aaagccaatg ggaaataata acacaatgga tcaatgaatc agatgcagtg atattattgt
    12781 taggttctag ttatggaaca attgatagtg aagaaaatat tagctataca gaaatggagt
    12841 acaattttgc taaatcttta ggtaaaccta tatatgtttt tgagatgaat aaagcatcta
    12901 ccgaatccgc ggaaaagtct aaaaaattag atgagtttaa gacaaaagtt aaagaaaata
    12961 gactaattag tccaaatatt aatgatattt cggaattaaa aagtaaagta tctcagactt
    13021 taatgcaaag tgtacctagt gaaattaaag aaaatagtgg atggataaga gtacaggatt
    13081 gtggtaaaaa tgtaaaaaaa taaaaaaatt ggatgctata caaagagatt tagatacata
    13141 tgattttttg aaagaagaac tttataaaat attcatgtat gtaaaaactt tttatttcca
    13201 gcacacacca tttgatgata gttatattga agatatagaa aactacctgc taaattatga
    13261 aaataatcca cataaatcat tcatgaaaat aaaagtttat gattataaaa actttttaaa
    13321 acatttaaaa aacatattga ttttaattaa acaaggaaaa aagccattag ctcaagccgg
    13381 tcattttaaa ttaagctttt acgaagagga tttaaaattg ttacaaaaaa aattataagg
    13441 ctacgctagt cgatattaaa ggattgaata aacattttta taaggaatgt gataggtgct
    13501 taaaagcata taatattttt attgagggta taaataaaca tttatatgaa tgatataagt
    13561 acaccctaat catacatata taattgttgt cactttactc gatatatgag aatgacttta
    13621 cctaataaat gagaaaagca acgcactata ttaaaatgcg ttgctttttc tattatcgaa
    13681 tacctataac taaactatct ctagctgttt ctacaacttc tgtacttatt ttatctaaac
    13741 catttatatc cataattctg tctatctgcg caaataaacg atgaatcagc ctaaaattcc
    13801 cttttgtaat tttaataatc gtcgttattg cctcataatc agtaaagtct tcgagtttta
    13861 aatcaaatcc taagtcttgc cacttatatt ctaatatatg atgcgtctca tctttactta
    13921 gattatcaaa ttcatgcgca aaacctatac gcgaatatag ttgaggataa cgagatagtt
    13981 ttttctctat acccggcata ccaataaata tcattgctaa attatgttca tcataaatag
    14041 ctcttaattg ctctaaatgt tgcactttaa ggcgatcaat ctcatctact ataattaaat
    14101 caatatattt aaacatatca ctataatgtt tactatgttc atgtccatac ttatttacaa
    14161 catgtaattt ttgacccaaa tcaatgattg cagtaatact atataaatca ttccttaatt
    14221 tagtttgttt ttctgctggt gcattataaa atattttatc caccgatagt atgtcatcgg
    14281 tcgttttact agctaaatct tcccaacctc tatggttaac ttgtttttca atagtatccc
    14341 aatttgtgta atacctagac gataaagttt ttccgacacc aggttgacca taacatatac
    14401 caatatactg atatttaata caagcatcac aaaattcagc aaagcgttta tactctttcg
    14461 tttcaatgaa attttgattt ttagtcatta cgatatctct ttaatttttt gacgttttta
    14521 gtcgtttctt gaggtgaata accacaattt ttttcttcct taattaattc cgtggtactt
    14581 ggactagcaa tattttgttt taagtgtttt cttctctgac tacgagcgtg ctgtatgtct
    14641 tttatatcta tggagtaatc agctatttct ggacatatag cagtacaaag aaattcatct
    14701 ctataaaaca cacgtatttc agccatatca tttgggttat aacgaatcag tacatattca
    14761 cctacataag cttctagatt agtattactg tatcgaaaac cttgaaaatg aatgccatct
    14821 gaatgaactt ttctagattt aggtatttcc aacaataata aatcaagttg ttctaagcta
    14881 cttggcatat tagggaaaaa gtgattacta ttccaatgac tgataggcgt ggtatgaata
    14941 gtactatgtt ctttttgatt ataatcttca attaaaaagt aacgtaattt ttcttcaaaa
    15001 ttgtgaaaat ttattagatt actaggagta tcattattgt ttatatatcc aggcagttgt
    15061 tctaagaaag tttgattaac tgtctgaaag aatcgttcta tttttccacg accacgagga
    15121 acaccaactt tcgaaaacat caagttaatt ttcaaatcaa tagcgacttg ttccatatga
    15181 tgtgaagtaa agtcacttcc atgatctgtg tagaattttt cgggtatacc acacactggc
    15241 caattggtat catttttatt ccatattgct tggtgtagtg ttaatgctgt gttttgagca
    15301 ttggggggca tcaaaactta agaaatagcc tgcaattgca cgactatagt catccataat
    15361 aatagttagc catggtctat tgatattacc ttttttggtc taatataaag atatctagca
    15421 aagtatggtc tgcttgccat atttcattgg gtctcgagga ttctctaatt tgtattaaat
    15481 cgtacttatt ttgatagtat ttttcaccct gatgagagaa atcaataaca gacttaggca
    15541 tcgctttaat aacactataa atttgtttat aacttggtat atcaaaatta ttttctttac
    15601 agtaattagt gattttccta tgaattgtgg ctatactatt tcttttattc ataagcgcaa
    15661 ggcgttcaat ttcatcaatt atctttggtt ctattttacg tgttccttta tcagctcttg
    15721 tcgcatagat tagtccttta agtccttgtt ctttatatga cttattccac ctataaaggg
    15781 tgcttaacgc aatcccttta cttttagaaa tacttgataa agattgttcg cctaggataa
    15841 aaggttttat aatattgtac ttttgagtag ctttttttac gtttggcttc agaaaaatta
    15901 gttagatact tctccttgtt tttcatcttc cttgtcctcc aatttattga ggtaacgata
    15961 aattgttgta cgtgaaacat gccactgttc tgcaattgtc ttaattggcg tgccattatc
    16021 ataaagggtc ttaagtaagt ttaaatcttt ttgatttaat ttttctggtc tgcctccata
    16081 tcggcctcta gcacgtgctg caattcggcc agctgaagaa cgctctaaaa ttaaattacg
    16141 ttcaaattct gcaaatgctg cgaataaatg aaataataat tgtccagttg aacttgattt
    16201 atccattgtt atattttctt ctaaactatg gaaacttaca cctcgttcgt taagctcatt
    16261 aactaatgtg attaaatcct ccatattacg tcccaatcta tctaatctcc aaacaacaat
    16321 cgtatctcct gacctcgcaa attcaattgc tttatctaaa ccaggtcttt tactttttga
    16381 accactcata tggtcattaa atatcttttc acaaccatat gtatttaatc gatcctcctg
    16441 taaatttaaa ttttgtaatc cagttgaaac tcttgcataa cctattttca aaatacaaac
    16501 ctcctatata catcttcagt gtaccataac ttaattacaa ggtcttttat gaacatagat
    16561 tttttgttgg gtttttgaac acataatcct atgtaattct tacttattta gacataaaag
    16621 aagagtgtac agaaaatggt tattttctgt acactctcat ctttaataat atattttaaa
    16681 tgtcattaac aaaactaatt taataagagt caagcatagt ttacatatgt attatgtttg
    16741 aaacatacct ctaattactt tttactaata tcatttaaaa tatctcgcaa ttcttcaatt
    16801 tctttgttat ttaattcttc atttttcgca aaattcaaca ctaaactttt catatcccct
    16861 ccatacagtt tattaagaaa ggttttagca gttttcattt taatatcgtc ttctttaata
    16921 tttgatgagt aaaaataaat attttctgat ttgtatcgtt ttataatctc tttttttata
    16981 tagtcttgtg attaatgttc taatcgtttt atcactaact tctttatatt tttgaatttc
    17041 aactacaatt tcattagctg atactgattt tttatcccat attatattca taacatccca
    17101 ttcagccata gatatttcaa cttgcttatt ggccatttaa aacacccatt ccttttaata
    17161 ttttttcact tattaattca gcatttttcc cagacgggtt tccatctgat aaatgtgtag
    17221 caaaataata cttatcatga tttgtaatta cgtaacctac aaaccaccca ttattatact
    17281 tcccgtttac tatacctgta cctgttttcc catacagttc atacttttca tttttcttaa
    17341 tcaataatga agaagataat tgattctttg ctttttttac taaaatggtt attttgttcc
    17401 atcatatttt taaaaactat tacttgttca agattagata ttttcaaact atcttccatc
    17461 caatagcttt tataacttcc caaattttca ttaccataat ttaattgctt gagttgagcc
    17521 gcagtatagt tctttggtat ttgattacta atacgttcga agtaccaatt aactgaattt
    17581 tgcattgctg tatttaaatc ttgttcctta ttccaagact cgaaaagata atgtttatga
    17641 ttccatgaca tacgtgaatt tttatcactt ataatatgac ggtcaagtcc aaacagtgct
    17701 aaataaattt tgtaagttga atcaggagaa tatctttttc tactttcttt ttcattataa
    17761 atatagtatt tgtctttctt catgctgtac ataacgaaag atccactatt tgaaccaaaa
    17821 tttttacttt catctaaaat ttggtaatcg ctttgtaagg gcttttttat aattataatc
    17881 agttaaggat tgccccatta aaaactggct ttgaattatc atgataaaaa aagtaaaaat
    17941 acaaataaaa attagaatta attttgactg ctttttcaga tcggcttctt ttatattaat
    18001 taatctattt ttgagtaatg attttttacc attaaatgaa tggcttaata tatttttgtt
    18061 gaaaaatgag gtttttaata cggagtccat aatagattcc gcataagttt taaattcatt
    18121 tttgttaata ttattaagga caaatctatc ggcttctact tcattgtcat gaattatctt
    18181 tctttttaca atatgtacta atggattgta actcataata atagagaaga tattaaagat
    18241 aattaaatgt aaagtatctc tatttttagc atgagcatat tcatgcagta ttatatattt
    18301 tagtctttta tcaattacac ttttaaaata tgaactagga atcaaaataa tatatttccc
    18361 ataccaaaaa gttattggag attgaatagc ctctgctttt cgaatcacaa tatttttttt
    18421 atattgatgg ttgaaaagta tcgtatctat tttatttttt tcattttcgt ttagataaag
    18481 tgactgtttc tttaaatatt taagatataa taaggctttc aaaaatttaa aacttaaaat
    18541 aataactaaa actatccaaa taactgtgca gatattatca attgaatccc aattaaactt
    18601 atggatatct gttgcgaact cttgaacagg tttggtggta attatgttat ggttcaagtc
    18661 gtgtgactta ctttcaactg tgggcgcttg attattcaca ttattaaatt ttataaaaga
    18721 gaatttaatt gggataaaag gaattaatcc agcaagcaca gttagatacc aaactttata
    18781 atttaaacta taattaaaat agcgttttaa tatgtaccta aaaaatacta acaatagaaa
    18841 tataaaacaa aagcttacta cactcattat tagtaattta gccattttga caccttcttt
    18901 caaatattta taataaacaa ttgacatcaa tattacaatt gtaatattat tgttttgtaa
    18961 aaattacaac tgtaatatcg gagggtttat tttgaaaaag ttaatatttt taattgtaat
    19021 ggctttagtt ttaagtgcat gtaattcaaa cagttcacat gccaaagagt taaatgattt
    19081 agaaaaaaaa tataatgctc atattggtgt ttatgcttta gatactaaaa gtggtaagga
    19141 agtaaaattt aattcagata agagatttgc ctatgcttcg acttcaaaag cgataaatag
    19201 tgctattttg ttagaacaag taccttataa taagttaaat aaaaaagtac atattaacaa
    19261 agatgatata gttgcttatt ctcctatttt agaaaaatat gtaggaaaag acatcacttt
    19321 aaaagaactt attgaggctt caatgacata tagtgataat acagcaaaca ataaaattat
    19381 aaaagaaatc ggtggaatca aaaaagttaa acaacgtcta aaagaactag gagataaagt
    19441 aacaaatcca gttagatatg agatagaatt aaattactat tcgccaaaga gcaaaaaaag
    19501 atacttcaac gcctgctgct ttcggcaaga ctttaaataa acttatcgca aatggaaaat
    19561 taagcaaaaa aaataaaaat ttcttacttg atttaatgtt taataataaa aacggagaca
    19621 ctttaattaa agatggtgtt ccaaaagact ataaggttgc tgataaaagt ggtcaagcaa
    19681 taacatatgc ttctagaaat gatgttgctt ttgtttatcc taagggccaa tctgaaccta
    19741 ttgttttagt catttttacg aataaagaca ataaaagtga taagccaaat gataagttga
    19801 taagtgaaac cgccaagagt gtaatgaagg aattttaata ttctaaatgc ataataaata
    19861 ctgataacat cttatagttt gtattatatt ttctattatc gttgacatgt ataattttga
    19921 tatcaaaacc tgattttccc tttattattt tcgagattta ttttcttaat tctctttaac
    19981 aaactagaaa tattgtatat acaaaaaatc ataaataata gatgaatagt ttaattatag
    20041 gtgttcatca atcgaaaaag caacgtatct tatttaaagt gcgttgcttt tttctcattt
    20101 ataaggttaa ataattctca tatatcaagc aaagtgacat aattgttgaa tttatagtaa
    20161 ctgaaacgta tgattagggt gtatattaat tatgagatgg aaatcaatga ttgttggcta
    20221 tgcgagagta tcatcgaacg atcaaaattt agaaagacaa cttgaaaatt taaagacgtt
    20281 ttgtgctgaa aaaatattta cagaaaaaca gtctgggaaa tctattgaaa atagaccagt
    20341 acttcaagaa gcacttaact ttttgaggat gggagatcgg tttgtagtag aatccattga
    20401 ttgtttaggt cgtaattatg atgaagtggt tggcaatcca ttactggata agtttatgaa
    20461 agatttaatt attcaaatat tagcaatggt ttcagaacaa gagagaaatg aaagtaaacg
    20521 tcgacaagcg caaggaattc aagttgcgaa ggaaaaaggc gtatataaag ggcgcccctt
    20581 actttattca ccaaatgcta aagatccaca gaaacgtatt atttatcatc gcgttgtaga
    20641 aatgttagaa gaaggccaat caattagtaa aattgcgaaa
//
