LOCUS       CP124768               23312 bp    DNA     circular BCT 11-MAY-2023
DEFINITION  Klebsiella michiganensis strain 2022CK-00495 plasmid unnamed8,
            complete sequence.
ACCESSION   CP124768
VERSION     CP124768.1
DBLINK      BioProject: PRJNA288601
            BioSample: SAMN31152636
KEYWORDS    .
SOURCE      Klebsiella michiganensis
  ORGANISM  Klebsiella michiganensis
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 23312)
  AUTHORS   Hergert,J., Casey,R., Wagner,J., Young,E.L. and Oakeson,K.F.
  TITLE     2022CK-00495
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 23312)
  AUTHORS   Hergert,J., Casey,R., Wagner,J., Young,E.L. and Oakeson,K.F.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-APR-2023) Utah Public Health Laboratory, Utah Public
            Health Laboratory Infectious Disease submission group, 4431 S 2700
            W, Salt Lake City, UT 84129, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.9.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 126.0x
            Sequencing Technology :: Oxford Nanopore GridION; Oxford Nanopore
            MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 05/01/2023 13:40:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.5
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,393
            CDSs (total)                      :: 7,273
            Genes (coding)                    :: 7,098
            CDSs (with protein)               :: 7,098
            Genes (RNA)                       :: 120
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 9
            Pseudo Genes (total)              :: 175
            CDSs (without protein)            :: 175
            Pseudo Genes (ambiguous residues) :: 0 of 175
            Pseudo Genes (frameshifted)       :: 59 of 175
            Pseudo Genes (incomplete)         :: 121 of 175
            Pseudo Genes (internal stop)      :: 30 of 175
            Pseudo Genes (multiple problems)  :: 29 of 175
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..23312
                     /organism="Klebsiella michiganensis"
                     /mol_type="genomic DNA"
                     /strain="2022CK-00495"
                     /isolation_source="Rectal Swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1134687"
                     /plasmid="unnamed8"
                     /geo_loc_name="USA"
                     /collection_date="2022-02-25"
     gene            join(22291..23312,1..4)
                     /gene="istA"
                     /locus_tag="QJQ59_05130"
     CDS             join(22291..23312,1..4)
                     /gene="istA"
                     /locus_tag="QJQ59_05130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032490293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004803 - transposase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS21 family transposase"
                     /protein_id="WGZ97521.1"
                     /translation="MLTQEQTVEIRVLARQGHSIRHIARTLGVSRNTVRRYLRDPSVAR
                     YQPREPRPTKLGPFESYLRQRVEQAHPIWLPATVLNREIRAQGYGGGLSLLRAFLATLK
                     PARREAGPAVRFETEPGRQLQADFVVLRRARSPMSAFVATLGYSRMTFVTFVPDESFES
                     VRDSLLLAFDYLGGVPREVLFDNMKTVVLERDAYGDGKHRFHPGLLQLADDLGFRIRLC
                     RPYRAQTKGKVERFNRYFRESFYNPLLTRMKGTGLLLDCAAANRRVRDWLADEANVRVH
                     ATLNERPIDRWRQEREHLQPLPSRVRRDEAPLLDNSLRPVPLESLQHPLSVYDAIGEAC
                     R"
                     /name="istA"
     gene            1..781
                     /gene="istB"
                     /locus_tag="QJQ59_05135"
                     /pseudo=""
     CDS             1..781
                     /gene="istB"
                     /locus_tag="QJQ59_05135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152394.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS21-like element ISKpn7 family helper ATPase
                     IstB"
                     /name="istB"
     gene            1168..2049
                     /locus_tag="QJQ59_05140"
     CDS             1168..2049
                     /locus_tag="QJQ59_05140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015256839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbapenem-hydrolyzing class A beta-lactamase
                     KPC-3"
                     /protein_id="WGZ97522.1"
                     /translation="MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIG
                     VYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPW
                     SPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDR
                     WELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRA
                     AVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAA
                     RLALEGLGVNGQ"
                     /name="carbapenem-hydrolyzing class A beta-lactamase KPC-3"
     gene            complement(2299..3618)
                     /locus_tag="QJQ59_05145"
     CDS             complement(2299..3618)
                     /locus_tag="QJQ59_05145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1182-like element ISKpn6 family transposase"
                     /protein_id="WGZ97523.1"
                     /translation="MAASYLPYRPDQSYLLPPSLGEWLPEGHLAYFISETVDTLDLSAF
                     HARYAGGGPGNQPFHPAMMVKVLIYGYASGVFSSRKLARKLYEDVALRVLAAGNFPAHR
                     TLSDFRALHLTELENLFVQVVQLARECGLVKLGTIAVDGTKVKANASRHKAMSYKRMKP
                     AEDELHCEIKALLDRAKATDDQERNEPELDIPAEISRREKRLEAIQAAKARLEARQREA
                     DQARGRSEDDGRRPRHPDGSDKGGGSYKREFGVPDDRDQESFTDPDSRIMKHAGGGSEQ
                     SYNGYTAVDAEHQIIVAAELTNCAADSQALLGMLAAVQANTGEMPAQTLADAGFRSEAV
                     LAKVADHHGDVIVALGREGREDAKVNAKTHPHTAAIAAKLKTEQGDAAYRRRKSIVEAP
                     NGWIKAVMGLRQFSMRGLDKVQAEWKLVCMALNLRRMAYL"
                     /name="IS1182-like element ISKpn6 family transposase"
     gene            3991..4218
                     /locus_tag="QJQ59_05150"
     CDS             3991..4218
                     /locus_tag="QJQ59_05150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001046776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WGZ97524.1"
                     /translation="MFGFSPGELMNLCPDERLLFVRMISAMLRRSGGDAGAVMFEAYRH
                     IVSDTNQARRSYMLDLLESVRHDYVHGGYT"
                     /name="hypothetical protein"
     gene            complement(4266..4454)
                     /locus_tag="QJQ59_05155"
     CDS             complement(4266..4454)
                     /locus_tag="QJQ59_05155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WGZ97525.1"
                     /translation="MTKQESAALNMAKFIRAQSLLLLEKLDVLDLDDEAADCERMHEQA
                     EALYQKLSARFGIQDGE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(4709..5011)
                     /locus_tag="QJQ59_05160"
     CDS             complement(4709..5011)
                     /locus_tag="QJQ59_05160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005161566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TM2 domain-containing protein"
                     /protein_id="WGZ97526.1"
                     /translation="MSSMVYCRGCGKEIHETAKSCPHCGATNASSGSGEKSRIAAALLA
                     FFLGGFGVHKFYLGKIGQGFLYLIFCWTFIPAIIAFIEFIIYLCDSDEKFARKYG"
                     /name="TM2 domain-containing protein"
     gene            complement(6185..7900)
                     /gene="tnpR"
                     /locus_tag="QJQ59_05165"
     CDS             complement(6185..7900)
                     /gene="tnpR"
                     /locus_tag="QJQ59_05165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn4401 family resolvase TnpR"
                     /protein_id="WGZ97527.1"
                     /translation="MKTGQTTASSSTPVGFPDADSLAALRGWYAGLSSRAAVEHYLAAR
                     KAAGQSARGMLGHIRRQLIVFANSRHRPDLADVFQHAPEERQGRAGAVERAIRLLPTLP
                     APKPQISDSIDQWLSPRTVRALQAYGIHTLSALTVRIPRRRGWWKAIEGLGMTGARQVE
                     AFFAAHPQLTERARALIPIIQPSGIVPWEQLRLPNEVDGSQGNFRAPRNACTLNATNDY
                     EAVQAWLALHETVATQRAYRKEAARLILWAIVERGRALSSLTTDDAIAYRAFVRHPTPR
                     ERWVGPPRPRDSVEWRPFSGGLSARSAAYALTVLSALFRWLIEQRYVLANPFAGVKVRG
                     HALRPALDTARGFTEGEWLLLRAIADGLEWSYGWSEPAAQRLRFMLDFGYATGLRASEL
                     VGAVLGNVRLDEHGDHWLHLVGKGGKPGKVALPPLAYTALDQYLAQRQLPVSRERWNPK
                     TPLVGSLGEDGNAGITGPHLWCVLRRFFTQAAEAIEADHPVAAEKLRRATPHWMRHSHA
                     SHALARGAQLTAVRDNLRHASIATTSMYLHGDELERARQMRQAFGARHVKRGVD"
                     /name="tnpR"
     gene            8010..10751
                     /gene="tnpA"
                     /locus_tag="QJQ59_05170"
                     /pseudo=""
     CDS             8010..10751
                     /gene="tnpA"
                     /locus_tag="QJQ59_05170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015060658.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn4401 family transposase"
                     /name="tnpA"
     gene            10747..11151
                     /locus_tag="QJQ59_05175"
                     /pseudo=""
     CDS             10747..11151
                     /locus_tag="QJQ59_05175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032490293.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology. GO_process:
                     GO:0015074 - DNA integration [Evidence IEA]"
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="integrase core domain-containing protein"
                     /name="integrase core domain-containing protein"
     gene            11148..11927
                     /gene="istB"
                     /locus_tag="QJQ59_05180"
     CDS             11148..11927
                     /gene="istB"
                     /locus_tag="QJQ59_05180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS21-like element ISKpn7 family helper ATPase
                     IstB"
                     /protein_id="WGZ97528.1"
                     /translation="MNLQHERIDALCQQLKLERVATHYPVLAQQAVREDFSFTDFLEHL
                     LRHEAGCRQQRSRELLTRMACFPGIKTLEDYDFSFNPGVPKALVQELGSLAFVERAENV
                     VLIGPSGIGKTHLAIALGYKAAQAGVKTRFITAADLMLQLSTAQRQGRLKEYFNRAILG
                     PRLLVIDEIGYLPFGREEANLFFQVVAKRYEKGAMILTSNLPFSQWADAFAGDTTLTAA
                     MLDRLLHHAHILTLSGESYRLKDKRKAGVVRKNSKPE"
                     /name="istB"
     gene            12314..13195
                     /locus_tag="QJQ59_05185"
     CDS             12314..13195
                     /locus_tag="QJQ59_05185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015256839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbapenem-hydrolyzing class A beta-lactamase
                     KPC-3"
                     /protein_id="WGZ97513.1"
                     /translation="MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIG
                     VYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPW
                     SPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDR
                     WELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRA
                     AVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAA
                     RLALEGLGVNGQ"
                     /name="carbapenem-hydrolyzing class A beta-lactamase KPC-3"
     gene            complement(13445..14764)
                     /locus_tag="QJQ59_05190"
     CDS             complement(13445..14764)
                     /locus_tag="QJQ59_05190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1182-like element ISKpn6 family transposase"
                     /protein_id="WGZ97514.1"
                     /translation="MAASYLPYRPDQSYLLPPSLGEWLPEGHLAYFISETVDTLDLSAF
                     HARYAGGGPGNQPFHPAMMVKVLIYGYASGVFSSRKLARKLYEDVALRVLAAGNFPAHR
                     TLSDFRALHLTELENLFVQVVQLARECGLVKLGTIAVDGTKVKANASRHKAMSYKRMKP
                     AEDELHCEIKALLDRAKATDDQERNEPELDIPAEISRREKRLEAIQAAKARLEARQREA
                     DQARGRSEDDGRRPRHPDGSDKGGGSYKREFGVPDDRDQESFTDPDSRIMKHAGGGSEQ
                     SYNGYTAVDAEHQIIVAAELTNCAADSQALLGMLAAVQANTGEMPAQTLADAGFRSEAV
                     LAKVADHHGDVIVALGREGREDAKVNAKTHPHTAAIAAKLKTEQGDAAYRRRKSIVEAP
                     NGWIKAVMGLRQFSMRGLDKVQAEWKLVCMALNLRRMAYL"
                     /name="IS1182-like element ISKpn6 family transposase"
     gene            15137..15364
                     /locus_tag="QJQ59_05195"
     CDS             15137..15364
                     /locus_tag="QJQ59_05195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001046776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WGZ97515.1"
                     /translation="MFGFSPGELMNLCPDERLLFVRMISAMLRRSGGDAGAVMFEAYRH
                     IVSDTNQARRSYMLDLLESVRHDYVHGGYT"
                     /name="hypothetical protein"
     gene            complement(15412..15600)
                     /locus_tag="QJQ59_05200"
     CDS             complement(15412..15600)
                     /locus_tag="QJQ59_05200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WGZ97516.1"
                     /translation="MTKQESAALNMAKFIRAQSLLLLEKLDVLDLDDEAADCERMHEQA
                     EALYQKLSARFGIQDGE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(15855..16157)
                     /locus_tag="QJQ59_05205"
     CDS             complement(15855..16157)
                     /locus_tag="QJQ59_05205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005161566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TM2 domain-containing protein"
                     /protein_id="WGZ97517.1"
                     /translation="MSSMVYCRGCGKEIHETAKSCPHCGATNASSGSGEKSRIAAALLA
                     FFLGGFGVHKFYLGKIGQGFLYLIFCWTFIPAIIAFIEFIIYLCDSDEKFARKYG"
                     /name="TM2 domain-containing protein"
     gene            complement(16465..16578)
                     /locus_tag="QJQ59_05210"
     CDS             complement(16465..16578)
                     /locus_tag="QJQ59_05210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007772075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WGZ97518.1"
                     /translation="MHEPPVQSDRCALSGNYRLESNPERHDKAPLAAATGN"
                     /name="replication initiation protein"
     gene            complement(17330..19045)
                     /gene="tnpR"
                     /locus_tag="QJQ59_05215"
     CDS             complement(17330..19045)
                     /gene="tnpR"
                     /locus_tag="QJQ59_05215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn4401 family resolvase TnpR"
                     /protein_id="WGZ97519.1"
                     /translation="MKTGQTTASSSTPVGFPDADSLAALRGWYAGLSSRAAVEHYLAAR
                     KAAGQSARGMLGHIRRQLIVFANSRHRPDLADVFQHAPEERQGRAGAVERAIRLLPTLP
                     APKPQISDSIDQWLSPRTVRALQAYGIHTLSALTVRIPRRRGWWKAIEGLGMTGARQVE
                     AFFAAHPQLTERARALIPIIQPSGIVPWEQLRLPNEVDGSQGNFRAPRNACTLNATNDY
                     EAVQAWLALHETVATQRAYRKEAARLILWAIVERGRALSSLTTDDAIAYRAFVRHPTPR
                     ERWVGPPRPRDSVEWRPFSGGLSARSAAYALTVLSALFRWLIEQRYVLANPFAGVKVRG
                     HALRPALDTARGFTEGEWLLLRAIADGLEWSYGWSEPAAQRLRFMLDFGYATGLRASEL
                     VGAVLGNVRLDEHGDHWLHLVGKGGKPGKVALPPLAYTALDQYLAQRQLPVSRERWNPK
                     TPLVGSLGEDGNAGITGPHLWCVLRRFFTQAAEAIEADHPVAAEKLRRATPHWMRHSHA
                     SHALARGAQLTAVRDNLRHASIATTSMYLHGDELERARQMRQAFGARHVKRGVD"
                     /name="tnpR"
     gene            19155..22184
                     /gene="tnpA"
                     /locus_tag="QJQ59_05220"
     CDS             19155..22184
                     /gene="tnpA"
                     /locus_tag="QJQ59_05220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn4401 family transposase"
                     /protein_id="WGZ97520.1"
                     /translation="MSKKNKLLSVLSDAEQEALYGLPEFDDAQQLEYLAVTETELALAN
                     SRPSLHAKVYCLLQIGYFKAKHAFFSFDWDEVEDDCAFVLSRYFHGEVFEPKAITKHER
                     YTQREQIAKLFGYWPWSAAFLPQLEQQAARTVRRDVTPGFVAAELIVWLNEHKIIRPGY
                     TTLQELVSETLSAERRRLGNLLEQALDESAKAALSQLLVRDDTLSQLAALKQDAKNFGW
                     RQMVREREKRATLEPLHAIAKTLLPKLDVSQQNLLYYASLANFYTVHDLRNLKADQTQL
                     YLLCYAWVRYRQLSDNLVDAMAYHMKQLEDESSAGAKQSFADEQVRRQQETPRVGRLLS
                     LYVDDSVADPTPFGEVRQRAYKIMPRDTLQTTAQRMSVKPASKLALQWQAVDGLADRMR
                     RHLRPLYVALDLSGSNPDSPWLAALAWAKGVFAKQQRLSQRPLDEWPAATLPKRLRPYL
                     LTFDADGKPTGLHADRYEFWLYRQIRKRLQSGELYLDDSLQHRHFSDELVEMDRKIDVL
                     AKMEIPFLQQPVHAQLDALTAELRTQWLAFNRELKQGKLTHLEYNKDTQKLTWRKPKSE
                     NEKAREKAFYEKLPFCDVADVFRFVNDECKFLSAFTPMQPRYAKKVADADSLMAVIIAQ
                     AMNHGNHVMARTSDIPYHVLDSGYQQYLRQATLHAANDCISNAIATLPIFPYYSFDLET
                     LYGAVDGQKFSVERPTVKARYSRKYFGRGKGVVAYTLLCNHIPLNGYLIGAHDYEAHHV
                     FDIWYRNTSDIMPTAITGDMHSVNKANFAILHWFGRRFEPRFTDLNAQLKELYCADDPA
                     QYQACLIRPVGKIDCDLIHREKPNIDRIVATLGLKEMTQGTLIRKLCTYTTTNPTRRAI
                     FEFDKLIRSIYTLRYLRDPQLERNVHRSQNRLESYHQLRSAIAQVGGKKELTGRTDIEI
                     EISNQCARLIANTIIFYNSAILSRLVTKYEAAGNSKALALITKISPAAWRHILLNGHYT
                     FQSSGKTIDLDAIVAGLELE"
                     /name="tnpA"
     ARG             1169..2046
                     /name="blaKPC-3"
                     /gene="blaKPC-3"
                     /gene_name="carbapenem-hydrolyzing class A beta-lactamase
                     KPC-3"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             12315..13192
                     /name="blaKPC-3"
                     /gene="blaKPC-3"
                     /gene_name="carbapenem-hydrolyzing class A beta-lactamase
                     KPC-3"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     Typing          5795..5967
                     /name="MOBP"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="91.954"
                     /coverage="100.0"
                     /evalue="2.04e-62"
     Typing          16940..17112
                     /name="MOBP"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="91.954"
                     /coverage="100.0"
                     /evalue="2.04e-62"
     Typing          complement(5324..5870)
                     /name="rep_cluster_2335"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="93.26"
                     /coverage="90.0"
                     /evalue="0.0"
     Typing          complement(16470..17015)
                     /name="rep_cluster_2335"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="94.343"
                     /coverage="90.0"
                     /evalue="0.0"
ORIGIN
        1 atgaacctcc agcatgagcg gatcgacgcc ccagtgccag caactcaaac tcgaacgggt
       61 ggcaacgcat taccccgtcc tggcgcagca ggcggtgcgc gaggacttca gcttcaccga
      121 cttcctggaa cacctgttgc ggcatgaagc ggggtgtcgc cagcagcgca gccgcgaact
      181 gctgacgcgg atggcttgct tcccgggcat caagaccctg gaggactatg acttcagctt
      241 caaccccggc gtgcccaagg cactggtgca ggagctgggc agtctggcgt ttgtcgaacg
      301 ggccgagaac gtggtgctga tcggaccctc tggcatcggc aagacccacc tcgccatcgc
      361 cttgggttac aaggccgcgc aagccggggt caagacacgc ttcatcacgg cagccgacct
      421 gatgctgcaa ctgagcacgg cgcagcgaca agggcggctg aaggaatact tcaaccgcgc
      481 catcctcggt ccacggctgc tggtgatcga tgagatcggc tacctgcctt tcggacgcga
      541 ggaagcgaac ctgttctttc aggtggtggc gaagcgctat gagaaagggg cgatgatcct
      601 gacctcgaac ctgccgttca gccagtgggc cgacgcgttt gccggcgata ccaccctgac
      661 agccgcgatg ctggatcggc tgctgcacca tgcccatatc ctgaccctga gcggcgaaag
      721 ctaccgcttg aaggacaaga ggaaggcggg agtggtcagg aaaaattcca aacccgaatg
      781 atccaggtgg gtcagtatta ctttggtgat tcaggggtaa agtgggtcag ttttcagttg
      841 gtgttgacac cggcgtaccc tcggtgctat cttcgcgccc caatagtcgg ggcttggcca
      901 ggacttcctg aggccgtccg taacgtggat gccgaggtca ggcgaggtgg ccgacccatg
      961 aacgccgacc tgattcgttt ttcaatagcg ctggacgttg tggtgccagg gacttaccaa
     1021 cccgatgtgt gcccatccgg ggcagttaca gccgttacag cctctggaga gggagcggct
     1081 tgccgctcgg tgataatccc agctgtagcg gcctgattac atccggccgc tacacctagc
     1141 tccaccttca aacaaggaat atcgttgatg tcactgtatc gccgtctagt tctgctgtct
     1201 tgtctctcat ggccgctggc tggcttttct gccaccgcgc tgaccaacct cgtcgcggaa
     1261 ccattcgcta aactcgaaca ggactttggc ggctccatcg gtgtgtacgc gatggatacc
     1321 ggctcaggcg caactgtaag ttaccgcgct gaggagcgct tcccactgtg cagctcattc
     1381 aagggctttc ttgctgccgc tgtgctggct cgcagccagc agcaggccgg cttgctggac
     1441 acacccatcc gttacggcaa aaatgcgctg gttccgtggt cacccatctc ggaaaaatat
     1501 ctgacaacag gcatgacggt ggcggagctg tccgcggccg ccgtgcaata cagtgataac
     1561 gccgccgcca atttgttgct gaaggagttg ggcggcccgg ccgggctgac ggccttcatg
     1621 cgctctatcg gcgataccac gttccgtctg gaccgctggg agctggagct gaactccgcc
     1681 atcccaggcg atgcgcgcga tacctcatcg ccgcgcgccg tgacggaaag cttacaaaaa
     1741 ctgacactgg gctctgcact ggctgcgccg cagcggcagc agtttgttga ttggctaaag
     1801 ggaaacacga ccggcaacca ccgcatccgc gcggcggtgc cggcagactg ggcagtcgga
     1861 gacaaaaccg gaacctgcgg agtgtatggc acggcaaatg actatgccgt cgtctggccc
     1921 actgggcgcg cacctattgt gttggccgtc tacacccggg cgcctaacaa ggatgacaag
     1981 tacagcgagg ccgtcatcgc cgctgcggct agactcgcgc tcgagggatt gggcgtcaac
     2041 gggcagtaag gctctgaaaa tcatctattg gcccaccacc gccgcccttg cgggcggcat
     2101 ggattaccaa ccactgtcac atttaggcta ggagtctgcg cggcagagcc gtgtgaccgg
     2161 ttttctgtag agcactgacg atggcggcgg cgctctctgc aattggcaag gcgtcggcgc
     2221 caaggatacc aatcttgcgg cgcgcggcgt gttatgacga ctggggtgca tttgagccgc
     2281 cccatttaac cttcgccctc acagatacgc cattcgcctc agatttagcg ccatgcagac
     2341 gagcttccac tcggcttgca ccttgtccag gcccctcatg ctgaactgac gcaatcccat
     2401 caccgccttg atccaaccat tcggagcctc cacgatcgac ttgcgccggc ggtaagctgc
     2461 atcgccttgc tccgttttca atttcgccgc aatcgccgcc gtatgcggat gggtcttggc
     2521 attgaccttg gcatcttcac gtccctcgcg gccgagggca acgatgacat cgccgtggtg
     2581 atcggcgacc tttgccagaa cagcctcact acggaatccc gcatccgcca gcgtctgggc
     2641 cggcatttct ccggtgttgg cctgaactgc tgccagcatg cccagcagcg cctgactgtc
     2701 cgcggcgcag ttggtcaact ccgccgccac gatgatctgg tgctcggcat cgaccgctgt
     2761 gtacccgttg tagctctgct cggagccacc accggcgtgt ttcatgatcc ggctgtccgg
     2821 atcggtgaag ctttcctgat cacggtcatc cggcacacca aactcgcgtt tgtacgagcc
     2881 accgcccttg tccgagccat ccggatggcg aggccggcgg ccatcgtctt cgctgcgccc
     2941 ccgggcctgg tccgcttcac gctggcgcgc ttccaggcgc gcctttgccg cctggatcgc
     3001 ctccaggcgc ttctcgcggc gagaaatctc ggcaggaatg tccagctccg gctcgttacg
     3061 ctcctggtcg tcggtagcct tggcgcgatc aagcagcgcc ttgatctcgc aatgcaattc
     3121 gtcctcggcc ggcttcatgc gcttatagct catcgccttg tggcggctgg cgttggcttt
     3181 taccttggtg ccgtcgaccg cgatcgtgcc aagcttcacc agcccacatt cgcgcgccag
     3241 ttgcaccacc tgaacgaaca aattctcaag ctcggtcagg tgtagggcac ggaagtcact
     3301 cagcgtgcgg tgggccggga agtttccagc ggccagcaca cgcaacgcga catcctcgta
     3361 cagcttcctg gctagtttgc gcgaagagaa gacgccgctc gcgtaaccat agatcagcac
     3421 tttgaccatc atcgccggat gaaacggctg attgcccgga ccaccgccgg cataccgggc
     3481 gtggaatgcg ctcaagtcca gcgtatcgac agtctcgctg atgaagtagg caagatgccc
     3541 ttcaggtagc cactctccca gagaaggggg cagcagatag gattggtcgg gtcggtaagg
     3601 aaggtaactg gcagccatcc ccgtatcgtc ctcgatcttc cgccgatttg gcttctgccg
     3661 cgcaggctcc taggccaccg tagctaaaca tacgagaaaa accgcttctt gagcgctctc
     3721 tgagaccacc ttgccgacaa cgcagaaacg gttgcggaaa aatcggcgtt tccggcgtac
     3781 gccacccgac ctggacgaac tattgcggac ctggaactgg agtagcggaa ttccccgggg
     3841 tttcagcgtc gcgccacagc gcctcagata gatgcggtag cctttggcgg gtcgtcatgc
     3901 cgcggaccac ccccccaaaa aattccacaa tgcggaatgg cggaattttc tggggttccc
     3961 gcttaccccc cctaatagat gggtgctttc atgtttggtt tttcaccagg agaacttatg
     4021 aacctttgcc ccgatgaacg tctgctcttt gtgcggatga tttccgctat gcttcgccgt
     4081 tcgggcggtg atgcgggtgc tgttatgttt gaggcgtatc gccatattgt gtccgatacc
     4141 aatcaagctc gtcgttccta catgctcgac ctgctcgaaa gcgtcaggca tgactatgta
     4201 cacggtggat atacatagtt gccctggata cgcttttcgt ctaagtgagc gttcttttcg
     4261 tctctttatt cgccgtcctg tataccgaag cgtgcgctca gcttctgata aagcgcttct
     4321 gcctgttcgt gcattcgctc acagtcggct gcctcgtcat caagatcgag cacgtcgagt
     4381 ttttcgagca gcagcagcga ctgcgcccgg ataaattttg ccatgttcag tgcggctgat
     4441 tcctgttttg tcatacggct ttttcccggt tttatggtga tcgcagactg aaatcttact
     4501 tcattcactt gagtgcatag ccatgcaggt acgcagaaat catcaggggc gttttttctc
     4561 gatatgggca cagaaaggtg tatgtttcag gccggagtcc tcagaaacgc gctgagggcg
     4621 tctcaggcgg tgcgggcaac ggatgttatg gtaaatctgc ctcacagact ggtacaaaaa
     4681 aagccccgca gggctttttt gctatgagtt agccatattt tcttgcgaat ttttcatcgg
     4741 aatcgcatag ataaataata aactcaataa acgcgatgat cgcgggtatg aatgtccagc
     4801 aaaaaattag atacaggaat ccctgtccta ttttacctaa gtaaaattta tgtacgccaa
     4861 atccaccaag gaagaatgct aatagcgcgg ctgcgattct acttttttca cctgaacctg
     4921 aagaggcgtt tgtggctccg cagtgtgggc atgactttgc tgtttcgtgt atttccttgc
     4981 cgcatcctcg gcagtaaacc attgaactca ttttttatcc tcgagcttat ttttagttgg
     5041 gatgcataat atccgatgtt ttataacgat atgcatccta tatgctcggg tgggatagat
     5101 ttccattatg gtgaaggatc ttcttgagat cctttctgta gcgtcgtaat ctcttgctct
     5161 gtaaacgaaa aaaccgccca gcaaggcggt ttttcgaagg ttctcagagc agcaactctt
     5221 tgaaccgtgg taactggctt acgaggagcg caggaaccaa atctgttctt tcagtttagc
     5281 cttaacaggc gcataacttc aagactaact cctctaaatc agttaccagt ggctgctgcc
     5341 agtggcgctt tgtcgtgtct ttccgggttg gactcaagtt gatagttacc ggacaaggcg
     5401 cagcagtcgg actgaacggg gggttcgtgc atacagtcca gcttggagcg aactgccttc
     5461 ccggaactga gtgtcaggcg tggaatgaga taaacgcggc cataacagcg gaatgacacc
     5521 ggtaaaccga aaggcaggaa caggagagcg cacgagggag ctaccagggg gaaacgcctg
     5581 ggatctttat agtcctgtcg ggtttcgccg ccactgattt gagcgtcaga tttcgtgatg
     5641 cttgtcaggg gggcggagcc tatggaaaaa cggcttcgcc gcggccttat cgtttccctg
     5701 ttaagtttct tcctggcatc tcccaggaga tttccgcccc attcgtaagc ccgcaccgct
     5761 cgccgcagcc gaacgaccga gcggagcgag tcagtgagcg aggaagcgga atatctcctg
     5821 tctcatatat tccgcttacg ctctgctgct gcattttcct cctgccacat gaagcacttc
     5881 actgattccc gcacccgtgc ctacatagta agccagtata cactccgcta gcgctacgtg
     5941 actggttcag ggctgcgccc cgacacccgc taaaagcact gacgcgcctg cggcttgccc
     6001 aaccccgcgc cgtccgggaa agaatttccc gatcgacccg acgtttctgt ttacctgtga
     6061 tgttaacgtt tggatctttt tcccgggttt acctattttc ttctaatgaa gcgttcacag
     6121 ctgacgttaa taggggttct aagcgggaat cccagaaaat tccgtcattc cgtatgatga
     6181 aaattcagtc gactcctcgc ttgacgtgac gagcgccaaa agcctgccgc atctgcctgg
     6241 cgcgctcgag ctcatcgcca tgcaaataca tcgacgtcgt ggcgatcgac gcatggcgta
     6301 ggttgtcgcg caccgcggtg agctgagctc cccgggccaa cgcatggctg gcatgactgt
     6361 gacgcatcca atgaggcgtg gcacggcgca gcttttcggc ggcgaccgga tgatcggcct
     6421 caatggcctc agcggcttgc gtaaagaatc ttcgcaacac gcaccaaagg tgagggccgg
     6481 tgatgccggc attaccgtct tccccaagac tgcccaccag gggcgttttc ggattccacc
     6541 gttcccggct gactggcagt tgacgctgtg ccaagtattg gtccagcgcc gtatacgcga
     6601 gcggcggcaa ggccacctta cctggtttgc cacctttgcc aaccaaatgc agccagtggt
     6661 caccgtgctc gtcgaggcgg acattaccca ggacggcgcc gaccagttcg ctagcgcgca
     6721 ggcccgtggc atagccgaag tcgagcatga agcgcaggcg ttgtgctgcc ggctcggacc
     6781 agccgtagga ccattccagg ccgtctgcaa tggcgcgcag cagtagccat tctccctcgg
     6841 taaagcctcg cgccgtatcc agtgcgggcc gcaaggcgtg accgcgtacc ttgacgccgg
     6901 cgaaagggtt ggccagcaca tagcgctgct cgatgagcca ccggaacagc gccgagagca
     6961 ccgtcagcgc atacgctgcc gagcgtgcgg acaagccgcc cgagaagggg cgccattcca
     7021 ccgaatcgcg tggtcgaggt ggccccaccc aacgctcgcg cggggtcggg tgccggacaa
     7081 aggcccggta cgcgattgca tcgtccgtgg tcagggatga tagcgcccgt ccgcgttcga
     7141 cgatggccca caggattagc cgcgcagcct ccttgcgata ggcgcgctgt gtggcgacag
     7201 tctcgtgcag cgccagccag gcctgcacgg cctcgtagtc gttggtcgca ttcagcgtgc
     7261 aagcgttgcg cggggcccgg aaattgccct gcgagccgtc gacttcgttc ggcagacgca
     7321 actgctccca cggcacgatg ccgctgggct gaataatcgg gatcagggcc cgggcgcgct
     7381 cggtgagctg cggatgtgcg gcaaagaaag cctcgacctg ccgggcgcct gtcatgccga
     7441 gtccctcgat ggctttccac cagccacgcc ggcggggaat gcgcacggtc agcgccgaga
     7501 gggtgtggat accgtacgcc tgcagtgccc tgacggtcct cggagacagc cactggtcga
     7561 tgctgtcgct gatctggggc ttcggcgccg gcagcgtggg caagagccgg atcgcgcgtt
     7621 cgacggcacc cgcgcgcccc tgtcgctctt cgggggcgtg ctggaacacg tcggccagat
     7681 ccggccggtg gcggctgttg gcgaaaacga tgagctggcg gcggatatgc cccagcatcc
     7741 ctcgcgctga ttgaccggcg gccttgcgtg ccgccaggta gtgttcaacg gccgcgcgag
     7801 agctgagtcc cgcgtaccag ccgcgcaagg cagccagcga atccgcatcg ggaaagccga
     7861 ctggggtaga actcgaagcc gtagtctggc ccgttttcat atggacaggt tgcgattcga
     7921 aaagcgagta acgcgataat aacgattatt tcagtagaat cgaaaatgcc ccatgtttct
     7981 acgaaacctc aagatagcaa gaacgggcca tgagcaagaa gaacaagcta ctcagcgtcc
     8041 tatccgacgc cgaacaggag gccttgtatg gcctgccgga gttcgatgat gcgcagcagc
     8101 tggaatatct ggctgtgaca gaaaccgagt tggcgcttgc caacagccgg cccagtcttc
     8161 atgccaaggt ctattgcctc ttgcagatcg gctacttcaa ggccaagcat gccttcttca
     8221 gtttcgactg ggacgaagtc gaggacgatt gcgctttcgt gctgagccgc tatttccacg
     8281 gcgaggtgtt cgaacccaag gcgatcacca agcatgaacg ctacacccag cgcgagcaga
     8341 tcgccaaact attcggctac tggccgtggt cggccgcctt cctgccgcag ctcgagcagc
     8401 aggccgcacg gaccgtgcgg cgtgacgtaa cgccggggtt cgtcgccgcc gagctgatcg
     8461 tctggctcaa tgagcacaag attatccggc ccggctatac gaccttgcaa gagttggtca
     8521 gcgaaacgct atccgccgag cgccggcgcc tgggcaatct gctggagcaa gcgttggacg
     8581 aatctgccaa ggccgcgctg agccagcttc tggtccgtga tgacaccctg tcgcaactgg
     8641 cggcgctcaa gcaggacgcc aagaatttcg gctggcgcca gatggtccgc gagcgcgaaa
     8701 agcgcgccac gctggagccg ctgcacgcaa tcgccaagac actgctgcct aaactcgacg
     8761 tctcgcagca gaacctgctg tactacgcga gcctggcaaa cttctacacc gtccacgacc
     8821 tgcgcaatct gaaggccgat cagacccaac tctacctgct gtgctatgcc tgggtacgct
     8881 accggcagct ctccgacaac ctggtcgatg cgatggcgta ccacgtaagg cagttggagg
     8941 acgaaagctt gtatggtgcc aaacaatcct ttgccgacga gcaggtgcgc cgtcagcagg
     9001 aaacgccgcg ggtaggccgc ctgctgtcac tctacgttga tgatagcgtg gccgatccca
     9061 cgcccttcgg cgaggtgcgg cagcgcgcct acaagatcat gcctcgcgat acgctgcaaa
     9121 ccacggcgca gcgtatgagc gtgaagccgg cgagcaagct ggccttgcag tggcaggcgg
     9181 tggacgggct ggccgaccgc atgcgccgcc atcttcgtcc actgtacgtt gcgctcgacc
     9241 tctccggctc caatccagac agtccatggc ttgccgcgct ggcctgggcc aaaggtgttt
     9301 ttgccaagca gcagcggctg tcgcaacggc cactcgacga gtggcccgcg gcgacacttc
     9361 cgaaacgctt gcggccgtac ctgctgacct tcgacgccga cggtaaacca accggcctgc
     9421 acgctgaccg ctacgagttc tggctgtacc gccagatcag gaagcgtctc caatcgggtg
     9481 aactctacct cgacgacagc ctgcaacacc ggcacttctc agatgaactg gttgagatgg
     9541 acaggaagat cgatgtgctc gcaaaaatgg agatcccctt cctgcagcaa cccgtccatg
     9601 cccaactcga tgcgctgact gccgaactgc gcacgcagtg gctggcgttc aaccgcgagc
     9661 tgaaacaggg caagctgacg cacctcgaat acaacaagga cacgcagaaa ctgacctggc
     9721 gcaagcccaa gagcgagaat gagaaagcgc gcgaaaaggc attctacgag aagcttccgt
     9781 tctgcgacgt ggccgacgtg tttcgcttcg tcaacgacga gtgcaagttt ctgtcggcgt
     9841 tcacgcccat gcagccgcgc tacgcgaaga aggtcgccga cgctgacagc ctgatggcgg
     9901 tcatcatcgc gcaagcgatg aaccacggca accacgtcat ggcgcgcacc agcgacatcc
     9961 cgtaccacgt gctggatagc ggctaccagc agtacctgcg ccaggcaacg ctgcacgcgg
    10021 ccaacgactg catcagcaac gccatcgcca cgctaccgat cttcccatac tactcgttcg
    10081 acctcgaaac gctgtacggt gccgtcgacg ggcagaaatt cagcgtcgaa cggccgaccg
    10141 tgaaggcgcg ctattcgcgc aagtacttcg ggcgcggcaa gggcgtggtc gcctacacgc
    10201 tgctgtgcaa ccacatcccg ctcaacggct acctgatcgg cgcgcacgac tacgaggccc
    10261 accacgtgtt cgacatctgg tatcgcaaca cgtcggacat catgccgacc gcgatcaccg
    10321 gcgacatgca cagcgtcaac aaggccaact tcgccatcct gcattggttt ggccggcggt
    10381 tcgagccgcg cttcaccgac ctcaacgcgc aattgaaaga actctactgc gctgacgatc
    10441 cagcacagta tcaggcgtgc ctgattcggc cagtcgggaa aatcgactgc gatctcatcc
    10501 atcgcgagaa gccgaacatc gaccggatcg tcgccacact cgggctgaag gaaatgacgc
    10561 agggcacgct gatccgcaag ctgtgcacct acaccacgac gaacccgacg cggcgcgcga
    10621 tcttcgagtt cgacaagctc atccgcagca tctacacgct tcgctacctg cgcgatccgc
    10681 aactggaacg caacgtgcac cgctcgcaaa atcgcctcga gtcctaccat cagctacgct
    10741 cggccattgc ttcaactggc cgatgacctg gggttccgga tccggctgtg tcgcccgtat
    10801 cgggcccaga ccaaaggcaa ggtcgagcgc ttcaatcgct acttccgcga gagcttctac
    10861 aacccgttgc tgacccggat gaagggcacg gggctgctgc tcgattgtgc tgctgccaac
    10921 cgacgcgtcc gtgactggtt ggcagacgag gcgaatgtgc gggtccacgc caccctgaac
    10981 gagcgcccca tcgaccgttg gcggcaggag cgggaacacc tgcaaccctt gccatcccgt
    11041 gtgcggcgcg acgaggcccc cctgctggat aacagtctcc gcccggtacc actggaatct
    11101 ctccagcacc cactgtctgt ctatgacgca attggggagg cctgccgatg aacctccagc
    11161 atgagcggat cgacgccctg tgccagcaac tcaaactcga acgggtggca acgcattacc
    11221 ccgtcctggc gcagcaggcg gtgcgcgagg acttcagctt caccgacttc ctggaacacc
    11281 tgttgcggca tgaagcgggg tgtcgccagc agcgcagccg cgaactgctg acgcggatgg
    11341 cttgcttccc gggcatcaag accctggagg actatgactt cagcttcaac cccggcgtgc
    11401 ccaaggcact ggtgcaggag ctgggcagtc tggcgtttgt cgaacgggcc gagaacgtgg
    11461 tgctgatcgg accctctggc atcggcaaga cccacctcgc catcgccttg ggttacaagg
    11521 ccgcgcaagc cggggtcaag acacgcttca tcacggcagc cgacctgatg ctgcaactga
    11581 gcacggcgca gcgacaaggg cggctgaagg aatacttcaa ccgcgccatc ctcggtccac
    11641 ggctgctggt gatcgatgag atcggctacc tgcctttcgg acgcgaggaa gcgaacctgt
    11701 tctttcaggt ggtggcgaag cgctatgaga aaggggcgat gatcctgacc tcgaacctgc
    11761 cgttcagcca gtgggccgac gcgtttgccg gcgataccac cctgacagcc gcgatgctgg
    11821 atcggctgct gcaccatgcc catatcctga ccctgagcgg cgaaagctac cgcttgaagg
    11881 acaagaggaa ggcgggagtg gtcaggaaaa attccaaacc cgaatgatcc aggtgggtca
    11941 gtattacttt ggtgattcag gggtaaagtg ggtcagtttt cagttggtgt tgacaccggc
    12001 gtaccctcgg tgctatcttc gcgccccaat agtcggggct tggccaggac ttcctgaggc
    12061 cgtccgtaac gtggatgccg aggtcaggcg aggtggccga cccatgaacg ccgacctgat
    12121 tcgtttttca atagcgctgg acgttgtggt gccagggact taccaacccg atgtgtgccc
    12181 atccggggca gttacagccg ttacagcctc tggagaggga gcggcttgcc gctcggtgat
    12241 aatcccagct gtagcggcct gattacatcc ggccgctaca cctagctcca ccttcaaaca
    12301 aggaatatcg ttgatgtcac tgtatcgccg tctagttctg ctgtcttgtc tctcatggcc
    12361 gctggctggc ttttctgcca ccgcgctgac caacctcgtc gcggaaccat tcgctaaact
    12421 cgaacaggac tttggcggct ccatcggtgt gtacgcgatg gataccggct caggcgcaac
    12481 tgtaagttac cgcgctgagg agcgcttccc actgtgcagc tcattcaagg gctttcttgc
    12541 tgccgctgtg ctggctcgca gccagcagca ggccggcttg ctggacacac ccatccgtta
    12601 cggcaaaaat gcgctggttc cgtggtcacc catctcggaa aaatatctga caacaggcat
    12661 gacggtggcg gagctgtccg cggccgccgt gcaatacagt gataacgccg ccgccaattt
    12721 gttgctgaag gagttgggcg gcccggccgg gctgacggcc ttcatgcgct ctatcggcga
    12781 taccacgttc cgtctggacc gctgggagct ggagctgaac tccgccatcc caggcgatgc
    12841 gcgcgatacc tcatcgccgc gcgccgtgac ggaaagctta caaaaactga cactgggctc
    12901 tgcactggct gcgccgcagc ggcagcagtt tgttgattgg ctaaagggaa acacgaccgg
    12961 caaccaccgc atccgcgcgg cggtgccggc agactgggca gtcggagaca aaaccggaac
    13021 ctgcggagtg tatggcacgg caaatgacta tgccgtcgtc tggcccactg ggcgcgcacc
    13081 tattgtgttg gccgtctaca cccgggcgcc taacaaggat gacaagtaca gcgaggccgt
    13141 catcgccgct gcggctagac tcgcgctcga gggattgggc gtcaacgggc agtaaggctc
    13201 tgaaaatcat ctattggccc accaccgccg cccttgcggg cggcatggat taccaaccac
    13261 tgtcacattt aggctaggag tctgcgcggc agagccgtgt gaccggtttt ctgtagagca
    13321 ctgacgatgg cggcggcgct ctctgcaatt ggcaaggcgt cggcgccaag gataccaatc
    13381 ttgcggcgcg cggcgtgtta tgacgactgg ggtgcatttg agccgcccca tttaaccttc
    13441 gccctcacag atacgccatt cgcctcagat ttagcgccat gcagacgagc ttccactcgg
    13501 cttgcacctt gtccaggccc ctcatgctga actgacgcaa tcccatcacc gccttgatcc
    13561 aaccattcgg agcctccacg atcgacttgc gccggcggta agctgcatcg ccttgctccg
    13621 ttttcaattt cgccgcaatc gccgccgtat gcggatgggt cttggcattg accttggcat
    13681 cttcacgtcc ctcgcggccg agggcaacga tgacatcgcc gtggtgatcg gcgacctttg
    13741 ccagaacagc ctcactacgg aatcccgcat ccgccagcgt ctgggccggc atttctccgg
    13801 tgttggcctg aactgctgcc agcatgccca gcagcgcctg actgtccgcg gcgcagttgg
    13861 tcaactccgc cgccacgatg atctggtgct cggcatcgac cgctgtgtac ccgttgtagc
    13921 tctgctcgga gccaccaccg gcgtgtttca tgatccggct gtccggatcg gtgaagcttt
    13981 cctgatcacg gtcatccggc acaccaaact cgcgtttgta cgagccaccg cccttgtccg
    14041 agccatccgg atggcgaggc cggcggccat cgtcttcgct gcgcccccgg gcctggtccg
    14101 cttcacgctg gcgcgcttcc aggcgcgcct ttgccgcctg gatcgcctcc aggcgcttct
    14161 cgcggcgaga aatctcggca ggaatgtcca gctccggctc gttacgctcc tggtcgtcgg
    14221 tagccttggc gcgatcaagc agcgccttga tctcgcaatg caattcgtcc tcggccggct
    14281 tcatgcgctt atagctcatc gccttgtggc ggctggcgtt ggcttttacc ttggtgccgt
    14341 cgaccgcgat cgtgccaagc ttcaccagcc cacattcgcg cgccagttgc accacctgaa
    14401 cgaacaaatt ctcaagctcg gtcaggtgta gggcacggaa gtcactcagc gtgcggtggg
    14461 ccgggaagtt tccagcggcc agcacacgca acgcgacatc ctcgtacagc ttcctggcta
    14521 gtttgcgcga agagaagacg ccgctcgcgt aaccatagat cagcactttg accatcatcg
    14581 ccggatgaaa cggctgattg cccggaccac cgccggcata ccgggcgtgg aatgcgctca
    14641 agtccagcgt atcgacagtc tcgctgatga agtaggcaag atgcccttca ggtagccact
    14701 ctcccagaga agggggcagc agataggatt ggtcgggtcg gtaaggaagg taactggcag
    14761 ccatccccgt atcgtcctcg atcttccgcc gatttggctt ctgccgcgca ggctcctagg
    14821 ccaccgtagc taaacatacg agaaaaaccg cttcttgagc gctctctgag accaccttgc
    14881 cgacaacgca gaaacggttg cggaaaaatc ggcgtttccg gcgtacgcca cccgacctgg
    14941 acgaactatt gcggacctgg aactggagta gcggaattcc ccggggtttc agcgtcgcgc
    15001 cacagcgcct cagatagatg cggtagcctt tggcgggtcg tcatgccgcg gaccaccccc
    15061 ccaaaaaatt ccacaatgcg gaatggcgga attttctggg gttcccgctt acccccccta
    15121 atagatgggt gctttcatgt ttggtttttc accaggagaa cttatgaacc tttgccccga
    15181 tgaacgtctg ctctttgtgc ggatgatttc cgctatgctt cgccgttcgg gcggtgatgc
    15241 gggtgctgtt atgtttgagg cgtatcgcca tattgtgtcc gataccaatc aagctcgtcg
    15301 ttcctacatg ctcgacctgc tcgaaagcgt caggcatgac tatgtacacg gtggatatac
    15361 atagttgccc tggatacgct tttcgtctaa gtgagcgttc ttttcgtctc tttattcgcc
    15421 gtcctgtata ccgaagcgtg cgctcagctt ctgataaagc gcttctgcct gttcgtgcat
    15481 tcgctcacag tcggctgcct cgtcatcaag atcgagcacg tcgagttttt cgagcagcag
    15541 cagcgactgc gcccggataa attttgccat gttcagtgcg gctgattcct gttttgtcat
    15601 acggcttttt cccggtttta tggtgatcgc agactgaaat cttacttcat tcacttgagt
    15661 gcatagccat gcaggtacgc agaaatcatc aggggcgttt tttctcgata tgggcacaga
    15721 aaggtgtatg tttcaggccg gagtcctcag aaacgcgctg agggcgtctc aggcggtgcg
    15781 ggcaacggat gttatggtaa atctgcctca cagactggta caaaaaaagc cccgcagggc
    15841 ttttttgcta tgagttagcc atattttctt gcgaattttt catcggaatc gcatagataa
    15901 ataataaact caataaacgc gatgatcgcg ggtatgaatg tccagcaaaa aattagatac
    15961 aggaatccct gtcctatttt acctaagtaa aatttatgta cgccaaatcc accaaggaag
    16021 aatgctaata gcgcggctgc gattctactt ttttcacctg aacctgaaga ggcgtttgtg
    16081 gctccgcagt gtgggcatga ctttgctgtt tcgtgtattt ccttgccgca tcctcggcag
    16141 taaaccattg aactcatttt ttatcctcga gcttattttt agttgggatg cataatatcc
    16201 gatgttttat aacgatatgc atcctatatg ctcgggtggg atagatttcc attatggtga
    16261 aggatcttct tgagatcctt tctgtagcgt cgtaatctct tgctctgtaa acgaaaaaac
    16321 cgcccagcaa ggcggttttt cgaaggttct cagagcagca actctttgaa ccgtggtaac
    16381 tggcttacga ggagcgcagg aaccaaatct gttctttcag tttagcctta acaggcgcat
    16441 aacttcaaga ctaactcctc taaatcagtt accagtggct gctgccagtg gcgctttgtc
    16501 gtgtctttcc gggttggact caagacgata gttaccggac aaggcgcagc ggtcggactg
    16561 aacggggggt tcgtgcatac agtccagctt ggagcgaact gcctacccgg aactgagtgt
    16621 caggcgtgga atgagataaa cgcggccata acagcggaat gacaccggta aaccgaaagg
    16681 caggaacagg agagcgcacg agggagccac cagggggaaa cgcctggtat ctttaagtcc
    16741 tgtcgggttt cgccaccact gatttgagcg tcagatttcg tgatgcttgt caggggggcg
    16801 gagcctatgg aaaaacggct tcgccgtggc cttcttgctt ccctgttaag cttcttcctg
    16861 gaagatgcca ggaaatttcc gccccgccag taagccggta ccgctcgccg cagccgaacg
    16921 accgagcgga gcgagtcagt gagcgaggaa gcggaatatc tcctgtctca tatattccgc
    16981 ttacgctctg ctgctgcatt ttcctcctgc cacatgaagc acttcactga ttcccgcacc
    17041 cgtgcctaca tagtaagcca gtatacactc cgctagcgct acgtgactgg ttcagggctg
    17101 cgccccgaca cccgctaaaa gcactgacgc gcctgcggct tgcccaaccc cgcgccgtcc
    17161 gggaaagaat ttcccgatcg acccgacgtt tctgtttacc tgtgatgtta acgtttggat
    17221 ctttttcccg ggtttaccta ttttcttcta atgaagcgtt cacagctgac gttaataggg
    17281 gttctaagcg ggaatcccag aaaattccgt cattccgtat gatgaaaatt cagtcgactc
    17341 ctcgcttgac gtgacgagcg ccaaaagcct gccgcatctg cctggcgcgc tcgagctcat
    17401 cgccatgcaa atacatcgac gtcgtggcga tcgacgcatg gcgtaggttg tcgcgcaccg
    17461 cggtgagctg agctccccgg gccaacgcat ggctggcatg actgtgacgc atccaatgag
    17521 gcgtggcacg gcgcagcttt tcggcggcga ccggatgatc ggcctcaatg gcctcagcgg
    17581 cttgcgtaaa gaatcttcgc aacacgcacc aaaggtgagg gccggtgatg ccggcattac
    17641 cgtcttcccc aagactgccc accaggggcg ttttcggatt ccaccgttcc cggctgactg
    17701 gcagttgacg ctgtgccaag tattggtcca gcgccgtata cgcgagcggc ggcaaggcca
    17761 ccttacctgg tttgccacct ttgccaacca aatgcagcca gtggtcaccg tgctcgtcga
    17821 ggcggacatt acccaggacg gcgccgacca gttcgctagc gcgcaggccc gtggcatagc
    17881 cgaagtcgag catgaagcgc aggcgttgtg ctgccggctc ggaccagccg taggaccatt
    17941 ccaggccgtc tgcaatggcg cgcagcagta gccattctcc ctcggtaaag cctcgcgccg
    18001 tatccagtgc gggccgcaag gcgtgaccgc gtaccttgac gccggcgaaa gggttggcca
    18061 gcacatagcg ctgctcgatg agccaccgga acagcgccga gagcaccgtc agcgcatacg
    18121 ctgccgagcg tgcggacaag ccgcccgaga aggggcgcca ttccaccgaa tcgcgtggtc
    18181 gaggtggccc cacccaacgc tcgcgcgggg tcgggtgccg gacaaaggcc cggtacgcga
    18241 ttgcatcgtc cgtggtcagg gatgatagcg cccgtccgcg ttcgacgatg gcccacagga
    18301 ttagccgcgc agcctccttg cgataggcgc gctgtgtggc gacagtctcg tgcagcgcca
    18361 gccaggcctg cacggcctcg tagtcgttgg tcgcattcag cgtgcaagcg ttgcgcgggg
    18421 cccggaaatt gccctgcgag ccgtcgactt cgttcggcag acgcaactgc tcccacggca
    18481 cgatgccgct gggctgaata atcgggatca gggcccgggc gcgctcggtg agctgcggat
    18541 gtgcggcaaa gaaagcctcg acctgccggg cgcctgtcat gccgagtccc tcgatggctt
    18601 tccaccagcc acgccggcgg ggaatgcgca cggtcagcgc cgagagggtg tggataccgt
    18661 acgcctgcag tgccctgacg gtcctcggag acagccactg gtcgatgctg tcgctgatct
    18721 ggggcttcgg cgccggcagc gtgggcaaga gccggatcgc gcgttcgacg gcacccgcgc
    18781 gcccctgtcg ctcttcgggg gcgtgctgga acacgtcggc cagatccggc cggtggcggc
    18841 tgttggcgaa aacgatgagc tggcggcgga tatgccccag catccctcgc gctgattgac
    18901 cggcggcctt gcgtgccgcc aggtagtgtt caacggccgc gcgagagctg agtcccgcgt
    18961 accagccgcg caaggcagcc agcgaatccg catcgggaaa gccgactggg gtagaactcg
    19021 aagccgtagt ctggcccgtt ttcatatgga caggttgcga ttcgaaaagc gagtaacgcg
    19081 ataataacga ttatttcagt agaatcgaaa atgccccatg tttctacgaa acctcaagat
    19141 agcaagaacg ggccatgagc aagaagaaca agctactcag cgtcctatcc gacgccgaac
    19201 aggaggcctt gtatggcctg ccggagttcg atgatgcgca gcagctggaa tatctggctg
    19261 tgacagaaac cgagttggcg cttgccaaca gccggcccag tcttcatgcc aaggtctatt
    19321 gcctcttgca gatcggctac ttcaaggcca agcatgcctt cttcagtttc gactgggacg
    19381 aagtcgagga cgattgcgct ttcgtgctga gccgctattt ccacggcgag gtgttcgaac
    19441 ccaaggcgat caccaagcat gaacgctaca cccagcgcga gcagatcgcc aaactattcg
    19501 gctactggcc gtggtcggcc gccttcctgc cgcagctcga gcagcaggcc gcacggaccg
    19561 tgcggcgtga cgtaacgccg gggttcgtcg ccgccgagct gatcgtctgg ctcaatgagc
    19621 acaagattat ccggcccggc tatacgacct tgcaagagtt ggtcagcgaa acgctatccg
    19681 ccgagcgccg gcgcctgggc aatctgctgg agcaagcgtt ggacgaatct gccaaggccg
    19741 cgctgagcca gcttctggtc cgtgatgaca ccctgtcgca actggcggcg ctcaagcagg
    19801 acgccaagaa tttcggctgg cgccagatgg tccgcgagcg cgaaaagcgc gccacgctgg
    19861 agccgctgca cgcaatcgcc aagacactgc tgcctaaact cgacgtctcg cagcagaacc
    19921 tgctgtacta cgcgagcctg gcaaacttct acaccgtcca cgacctgcgc aatctgaagg
    19981 ccgatcagac ccaactctac ctgctgtgct atgcctgggt acgctaccgg cagctctccg
    20041 acaacctggt cgatgcgatg gcgtaccaca tgaagcagtt ggaggacgaa agcagcgctg
    20101 gtgccaaaca atcctttgcc gacgagcagg tgcgccgtca gcaggaaacg ccgcgggtag
    20161 gccgcctgct gtcactctac gttgatgata gcgtggccga tcccacgccc ttcggcgagg
    20221 tgcggcagcg cgcctacaag atcatgcctc gcgatacgct gcaaaccacg gcgcagcgta
    20281 tgagcgtgaa gccggcgagc aagctggcct tgcagtggca ggcggtggac gggctggccg
    20341 accgcatgcg ccgccatctt cgtccactgt acgttgcgct cgacctctcc ggctccaatc
    20401 cagacagtcc atggcttgcc gcgctggcct gggccaaagg tgtttttgcc aagcagcagc
    20461 ggctgtcgca acggccactc gacgagtggc ccgcggcgac acttccgaaa cgcttgcggc
    20521 cgtacctgct gaccttcgac gccgacggta aaccaaccgg cctgcacgct gaccgctacg
    20581 agttctggct gtaccgccag atcaggaagc gtctccaatc gggtgaactc tacctcgacg
    20641 acagcctgca acaccggcac ttctcagatg aactggttga gatggacagg aagatcgatg
    20701 tgctcgcaaa aatggagatc cccttcctgc agcaacccgt ccatgcccaa ctcgatgcgc
    20761 tgactgccga actgcgcacg cagtggctgg cgttcaaccg cgagctgaaa cagggcaagc
    20821 tgacgcacct cgaatacaac aaggacacgc agaaactgac ctggcgcaag cccaagagcg
    20881 agaatgagaa agcgcgcgaa aaggcattct acgagaagct tccgttctgc gacgtggccg
    20941 acgtgtttcg cttcgtcaac gacgagtgca agtttctgtc ggcgttcacg cccatgcagc
    21001 cgcgctacgc gaagaaggtc gccgacgctg acagcctgat ggcggtcatc atcgcgcaag
    21061 cgatgaacca cggcaaccac gtcatggcgc gcaccagcga catcccgtac cacgtgctgg
    21121 atagcggcta ccagcagtac ctgcgccagg caacgctgca cgcggccaac gactgcatca
    21181 gcaacgccat cgccacgcta ccgatcttcc catactactc gttcgacctc gaaacgctgt
    21241 acggtgccgt cgacgggcag aaattcagcg tcgaacggcc gaccgtgaag gcgcgctatt
    21301 cgcgcaagta cttcgggcgc ggcaagggcg tggtcgccta cacgctgctg tgcaaccaca
    21361 tcccgctcaa cggctacctg atcggcgcgc acgactacga ggcccaccac gtgttcgaca
    21421 tctggtatcg caacacgtcg gacatcatgc cgaccgcgat caccggcgac atgcacagcg
    21481 tcaacaaggc caacttcgcc atcctgcatt ggtttggccg gcggttcgag ccgcgcttca
    21541 ccgacctcaa cgcgcaattg aaagaactct actgcgctga cgatccagca cagtatcagg
    21601 cgtgcctgat tcggccagtc gggaaaatcg actgcgatct catccatcgc gagaagccga
    21661 acatcgaccg gatcgtcgcc acactcgggc tgaaggaaat gacgcagggc acgctgatcc
    21721 gcaagctgtg cacctacacc acgacgaacc cgacgcggcg cgcgatcttc gagttcgaca
    21781 agctcatccg cagcatctac acgcttcgct acctgcgcga tccgcaactg gaacgcaacg
    21841 tgcaccgctc gcaaaatcgc ctcgagtcct accatcagct acgctcggcc attgcccagg
    21901 tcggcggtaa gaaggaactg accggtcgca ccgacattga aatcgagatc agcaaccagt
    21961 gcgcacggct gatcgccaac acgatcattt tctacaactc ggcaatcttg tcgcggctgg
    22021 tgaccaagta cgaggcggcc ggcaacagca aggcgctggc actcatcaca aaaatttcgc
    22081 ctgcggcatg gcggcacatc ctgctcaacg ggcactacac ctttcaaagc agcggcaaga
    22141 cgatcgatct cgatgcgatc gtcgcaggcc tggaactgga gtgacggaat tttcagcggt
    22201 tccgtgttag cagcagtgta aaactgaccc accccagcga agtaaaactg atccacctgg
    22261 gctagtttgg cggccttttc gaggccgtcg atgttgaccc aggagcaaac cgtggaaatc
    22321 agagttcttg cccgacaggg ccactccatc cggcacatcg cccgcacgtt gggggtctcg
    22381 cgcaataccg tgcgccgcta cctccgcgat ccgtcggtag cgcgatacca gccccgtgaa
    22441 ccacgcccca ccaaactggg gccatttgaa tcttatctgc ggcaacgggt cgagcaggcc
    22501 caccccatct ggctgcctgc caccgtcctg aatcgggaaa tccgcgctca agggtatggc
    22561 ggcggtctct cgttattgcg cgccttcctc gccacgctca agcccgcccg ccgcgaagca
    22621 ggtccggccg tccgtttcga gaccgagccc ggacggcagt tgcaggctga tttcgtggtc
    22681 ttgcgccggg ccagatcccc catgtcggcc ttcgtcgcca cgctgggata cagccgcatg
    22741 acgtttgtca ccttcgtacc ggacgaatcc ttcgagtccg tgcgggactc cctgttgctg
    22801 gcttttgact atctgggcgg tgtgccccgc gaggtgttgt tcgacaacat gaagaccgtg
    22861 gtgctggaac gcgatgccta cggtgacggc aagcaccgtt ttcaccccgg cttgcttcaa
    22921 ctggccgatg acctggggtt ccggatccgg ctgtgtcgcc cgtatcgggc ccagaccaaa
    22981 ggcaaggtcg agcgcttcaa tcgctacttc cgcgagagct tctacaaccc gttgctgacc
    23041 cggatgaagg gcacggggct gctgctcgat tgtgctgctg ccaaccgacg cgtccgtgac
    23101 tggttggcag acgaggcgaa tgtgcgggtc cacgccaccc tgaacgagcg ccccatcgac
    23161 cgttggcggc aggagcggga acacctgcaa cccttgccat cccgtgtgcg gcgcgacgag
    23221 gcccccctgc tggataacag tctccgcccg gtaccactgg aatctctcca gcacccactg
    23281 tctgtctatg acgcaattgg ggaggcctgc cg
//
