LOCUS       CP110573                9294 bp    DNA     circular BCT 21-NOV-2022
DEFINITION  Klebsiella pneumoniae strain INF341 plasmid pINF341.2, complete
            sequence.
ACCESSION   CP110573
VERSION     CP110573.1
DBLINK      BioProject: PRJNA646837
            BioSample: SAMEA3357226
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Foster-Nyarko,E., Cottingham,H., Wick,R., Judd,L.M., Lam,M.C.,
            Wyres,K.L., Tsang,K., David,S., Aanensen,D.M., Brisse,S. and
            Holt,K.E.
  TITLE     Nanopore-only assemblies for genomic surveillance of the global
            priority drug-resistant pathogen, Klebsiella pneumoniae
  JOURNAL   Unpublished
REFERENCE   2
  AUTHORS   Hawkey,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-OCT-2020) THE UNIVERSITY OF MELBOURNE, 30 Flemington
            Rd, Australia
REFERENCE   3  (bases 1 to 9294)
  AUTHORS   Foster-Nyarko,E., Cottingham,H., Judd,L.M., Hawkey,J., Wick,R. and
            Holt,K.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2022) Department of Infectious Diseases, Monash
            University, Level 2, The Burnet Institute, Melbourne, VIC 3004,
            Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.8.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 16x
            Sequencing Technology :: Illumina; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 11/03/2022 15:50:16
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.3
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,599
            CDSs (total)                      :: 5,477
            Genes (coding)                    :: 5,338
            CDSs (with protein)               :: 5,338
            Genes (RNA)                       :: 122
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 10
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 74 of 139
            Pseudo Genes (incomplete)         :: 66 of 139
            Pseudo Genes (internal stop)      :: 19 of 139
            Pseudo Genes (multiple problems)  :: 18 of 139
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            On Nov 21, 2022 this sequence version replaced LR890492.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="INF341"
                     /db_xref="taxon:573"
                     /plasmid="pINF341.2"
     gene            join(9124..9294,1..249)
                     /locus_tag="JMX00_00005"
     CDS             join(9124..9294,1..249)
                     /locus_tag="JMX00_00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="UZI75269.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="Exc2 family lipoprotein"
     gene            555..818
                     /locus_tag="JMX00_00010"
     CDS             555..818
                     /locus_tag="JMX00_00010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="UZI75270.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="plasmid stabilization protein"
     gene            808..1107
                     /locus_tag="JMX00_00015"
     CDS             808..1107
                     /locus_tag="JMX00_00015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="UZI75271.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(1169..1546)
                     /locus_tag="JMX00_00020"
     CDS             complement(1169..1546)
                     /locus_tag="JMX00_00020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 1"
                     /protein_id="UZI75272.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="entry exclusion protein 1"
     gene            1615..1794
                     /locus_tag="JMX00_00025"
     CDS             1615..1794
                     /locus_tag="JMX00_00025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="UZI75273.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(1822..2352)
                     /locus_tag="JMX00_00030"
     CDS             complement(1822..2352)
                     /locus_tag="JMX00_00030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UZI75274.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(2359..3090)
                     /locus_tag="JMX00_00035"
     CDS             complement(2359..3090)
                     /locus_tag="JMX00_00035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-relaxation family protein"
                     /protein_id="UZI75275.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="replication-relaxation family protein"
     gene            complement(3090..5054)
                     /locus_tag="JMX00_00040"
     CDS             complement(3090..5054)
                     /locus_tag="JMX00_00040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="UZI75276.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(6535..6684)
                     /locus_tag="JMX00_00045"
     CDS             complement(6535..6684)
                     /locus_tag="JMX00_00045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_component:
                     GO:0019867 - outer membrane [Evidence IEA]; GO_process:
                     GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="UZI75266.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(6769..7026)
                     /locus_tag="JMX00_00050"
     CDS             complement(6769..7026)
                     /locus_tag="JMX00_00050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="UZI75267.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            complement(7036..8721)
                     /locus_tag="JMX00_00055"
     CDS             complement(7036..8721)
                     /locus_tag="JMX00_00055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003723 - RNA binding [Evidence IEA]; GO_function:
                     GO:0016788 - hydrolase activity, acting on ester bonds
                     [Evidence IEA]; GO_function: GO:0043022 - ribosome binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E3/pyocin S6 family cytotoxin"
                     /protein_id="UZI75268.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin E3/pyocin S6 family cytotoxin"
     BGC             2036..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          5854..6432
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(2363..3090)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 atgatggtgc cttttttccg gcagttctgg gatatgggcg caaaggataa agcgaccgga
       61 aaatcacgga gtgatgtgca gcaacgcatt cagcagtttc acagtcagga atttttaaac
      121 tcactccaag gcacaacaca atttgcgggt accgattacc gcagcaaaga cctcacaccg
      181 aaaaaatcaa ggctactggc tgacaccatt tcagctgttt atctcgatgg ctatgaaggc
      241 agacagtaag tggatttacc ataacgcgtc attacgcgca ccgctcagac gggctcaggg
      301 cgtttccggc ggctacggga taaaacaggc aacaaccccc ccggaaaact gccggaaacg
      361 cgcccgataa attttatcct aatgcatgcc tatgcacgca actgcatggc atatgttttg
      421 acgtaaaatg gatgccgtaa gccctttttt accgactttc tgcttcatca gcctgactga
      481 cacgaccata ttctttcaga ccgccccctg ctaaacttcc ttcatattgc cgcattaacc
      541 cgggaggctc cgcaatgagc aacactacac actacgaaaa cgccaacttt cttcgggaac
      601 tggctgaaag cctgccccgc atactgccgg aaggtggccc ggacaaagct gcgctgttgc
      661 agcgactggc taacgaagaa ctggcccagg cagagtatga agatcaggtt cgcgccaaag
      721 tgaccgccgc ccgtgctgac acgcgtccgg gtatgaccac ggaacaactc cgccagcgcc
      781 tgcatggccg ttatcaggaa ctgcgcgatg ccgtatgacg tggaatggaa gcagggagcc
      841 atcgaggatg taacgacgct gtttgactat atcgcggaaa attcatccct gtgggatgcg
      901 cagaacgtta ccgaccgggt tctcgctgcg gcggacaaac tggccgactt cccgcgactc
      961 tatgaagtgg actcacgcta tggcgaggac gttcgccgga tcagtctgat gggacagcat
     1021 gtcctctatg atgttgatga ccagaccaga aaagtccggg ttctggccgt ggtcggccag
     1081 cgccagaatc cccatattgt tctctaataa ccggtgacgg ggacgcaatt cattgcgtgg
     1141 ccgtcgccgg ttggacaagc acagcgcgtc agcgttttcc ccacggccac caccggcgcg
     1201 gtgttccggc cggggtctct gctgtctccg gtttgtgttc cagcagtctc atggactgca
     1261 tttcctgccg tagcccggcc acctcctccc tgagtgcttt tatctccgcg atcaacgcgt
     1321 cggaggccat tttttcagtc tcacccgaca gtctcaactc gtcccgctcg tgagtctcat
     1381 cctgtcttaa ctcaccgtac acccggataa gctcgctggt atccaccacc cggccgccat
     1441 cagcttccgt acggtatgat acgcggcctt tcgccatatc ccgatacagg gaacttcggg
     1501 ctttacccgt cagttccgtc gcctgtctca ccgtcaccca cgccattgtc tcaccccgct
     1561 atttttgaga cagtatacct gacaggcgca caccatgccc ggaaggaaag aatcatgaca
     1621 aaacaggaaa aaacagccct caatatggct aaatttatta aggagcagtc gctgctattg
     1681 ctcgataaac tgaatgagct ggatatggat accccggccg acatgtgcga gcggctacac
     1741 gaggatgcgg aaacactctg gcaggtgatg cgggataagc tcggggagga ataacagcac
     1801 cggcatggcc ggtgctggca tttatttttt gccgaacggc caccaccggc gggcaggttt
     1861 gtcctccggc agttcaggta ccggcacgtt aaaatagcgg ctgttatatt cccgcatcag
     1921 ctccgctttc agcttctcgt tcaccgcgct ttccccgtgc cgctcactca ccacgtcaat
     1981 catcgcgtta atctgctccg gtgagcactt cccggcatca accacctgca caccgttctc
     2041 gatggcgaac cgctccacct tgcgatagag gtaatcacac agcttcattc ctgtgggttt
     2101 gttccgttcc cattgcggat ttttaccagt gaaaaagtac gtggcttttt cgtcgctgtt
     2161 gagccgctcg tcatacatcc cgatggattt catcatcgcc agatgctggg cccggtcgac
     2221 aaaacagaaa acatacgccc cggtctgcca ggcgagcacc accatatctt ccagatgctc
     2281 gctggtcggc atgatgcagc gctcgccgtt ccggtcctcc gcgtcttcaa taaataccat
     2341 gtacagcgcc ataatccctc actccgttgt cataaattta aagcacgcaa acaaccgttc
     2401 acgatccagc tctgccgttt tgcgggcctc gccggtctgt gggttcacga tttcatccac
     2461 cgacaggatt gcccgctgca ccctgacctg cgtcgcccgg tccgggcaga tgtaccagat
     2521 ttcatcgatg ccgttagctt tgcggttgaa cagatacccg gacaccactt cctgataccg
     2581 gcgacggctc ttgacggtgc gctccacctc aaacgccacc gttttaccgt ccagctccgc
     2641 cagggcgtcc ggcactttca tgcctttaag actcagacgg tgcagaatgc gccagccggt
     2701 ggcccctctg gcttccatat caaggcgcag ggattgcacg gccagccggt gcggcagatg
     2761 tgctgccgac acccttgacg gctgaaacgg aataacatcc gccagcggtt cgtcctcgtc
     2821 gaacgagaac gccacgccat gcggcgtcag cccccacacg ctgacctgac ggccgtccac
     2881 cggatatttg gtccggacca gcagcccttt cgccaccagg ctgtcgagga agcggtagac
     2941 cggctgcacc gccgcaatcc ccagccgccg cgcaaccagc tccgccgtgg aacacagctc
     3001 ttcccgcaac cagcgcaggg tcagccgggt tttctccgcg ttccgcgcct gtcgtttcgc
     3061 gtggctgacg ttgtacagct ccagcgccat cagtaaatcc ccgcaaaatc atcatccgct
     3121 ttcggcccgc cgccgtcggc cgggggccgg aactccgcca ggggatcggt tttcgccagc
     3181 accgggaaac gctgcaacgg gatttcccgg cgctcaaccc gcagcggact gctgaacgcc
     3241 atccgggcca cacccagccc ggtcatgacc gcgaacccgt ccggcaggtg ttgcagggtg
     3301 ttcacgtcaa acagcggccg cgcctccttc tggatgaagc tgtccccgct gatatgctcc
     3361 acgttccccg cctcccggct ggcacggcgg cgctccacgt ccaccctgat ttccccggtc
     3421 tgccccgccg cccactgcgc ggactccagg ctggccgccc ggtaaaacca gcggatcggc
     3481 gtgttatcca gtaccgtggt tttcacaaat tcagcgggca gatcctgccc gcactgcccg
     3541 aaatcgccca gcgactggtg cgcgagcaac agattgcagt cccggctgcg cagcgtcccc
     3601 agtgcgttca gtacatactt cgacagcaga tatttaattt catcgagcat cacgctgacg
     3661 tgtggccact cccggaactc gtcccgcgca atgatgattt gcgcgcagcg ggcaaacagc
     3721 attttttgca cacggatcac cgcctcgtcg tccatcgagc cgataacgta caggcagccg
     3781 ccgccgttga taatccccgc cacatcgatg ccactgtccg tctgcaggac gctcaggtca
     3841 gcgacgtttt ccagcctagt gatcaacccc ttcacgtcct ttttcagggc ctccggcagc
     3901 gcgtacgccg ccgccagcac ctgctgaatg tttgccccct gcggaaactg ctccgcaatc
     3961 agcttcgccg ctttctgctc gctgatgcgg tagtggtccg ccacgtcgcc ggtctcgccc
     4021 aggttaagcc cggcaatcag caggtttttc agcgcgtact ggtcgagatc gcggaacaga
     4081 ttcagctgcg ccggtttccc cggccgcaga tccagcaggg tgaagtccgg acagtgcgcc
     4141 cggaagacgt gcggcgccca tgcgtcccct ttggggtcga agtacaccac cgcgtccccg
     4201 aaatcgcgta cgcagcgaat gagcgcgttg gtggccatca cgctcttgcc gctcccgggc
     4261 aggccgagga tctgaatgtt ggtcttgcgc caggtatcac gcggaaccag caccggcttg
     4321 ccctgctcat ccttacccag aaacaccgcc tgctcctgcc gggcctgctc cgaggaaaaa
     4381 tcggccagcg cattaaccgg taccggctcc ccgaaatgca ggtggcgcac gtcggtcatc
     4441 tctcctgtcc gctggctgct gcgccggctc tcctgattca gtttcgcgtt caccgcctcg
     4501 tcagcagccg caaaatgacc gtcaagcagc aggaacgcca gcagccgcgc caacacaatc
     4561 ccgacagcca gcccgcccgc gcaccaggca atcccgaaca ggttagccgg ctgcagcagg
     4621 taataatctg cgtttgcgta gaggtccgga cgcaggacgg tttctcccca gctctcgata
     4681 aacacggcga caaccagccc ccccagaagg gccagaccgg ccgcgccggt cagccagtac
     4741 gcgtagttcc agacatgtcg acgtgccctg accatccgcc cgggcgaatc cagcgaggcc
     4801 agcaccgaaa atggcgctgg ccgtttatta tcgcgcttat agcgatcggc atactcccgt
     4861 cgctccttat gactcagccc cacaaaacgc atccgtccgg cccaaagttc agccagaccg
     4921 aaaaacaggc cgataactag gaaagccccg gccagaccgt aatactcctg gtacagccag
     4981 ctgacccacg gataaatctg ccgggccagc tccggaatgt gccacttcca ggcaagcgaa
     5041 tccgtattaa acatgttctc tctccttcag acgatggttt gccggcgtga tgtgcagccc
     5101 ccgctgcaca agccgcggac atgccccaag gcatggcggc ggcggtcacg tccgtggtga
     5161 ttgcgttcag ctttcaccac ggaggccagc ctctttccgc cccatgcgga aaaggcgcag
     5221 ccccggagga acaacgagca cgccccagcg tgtgagagga aaaggcggca ccccagtgcg
     5281 gtcttttccg gtgttccggc ccccgtcaga gttcgccata gcgagcggct gaccacccgc
     5341 aaaatcagga gcagctttgc tgcttcgcca ggtgcgtcca gcaccgtgga tttttgtggg
     5401 tggtcaggcg tgagcctgac gggggccggg tgaatttctg gcgtggccgg cgtccagccg
     5461 gacggagcca gaaagagggg gagagaccgt gcgtcggtgg cgtccagcca gcgtaagcag
     5521 gggatatccc cctgaggtca gccacgccct cgcggggatg acctgtattt ctccgtaagg
     5581 agaaaaaagc aacagagata ggttaacgta aaatgttcag cgaaaaaccg atatgattca
     5641 cctatcctgg taatttatta tcagggaata taaagactta atcaggggac aatatgccac
     5701 atcagcgcgt ccggtgtccg tcttgtaggt gccggggaaa ttgcgcctcc tcgctcactc
     5761 ggtcgctacg ctccggccgt gagactgcgg cgggcgctgc ggacacatgc aaagttaccc
     5821 acagattccg tgaataagca ggggactaac atgtgaggca aaacggcaag gccacgcagg
     5881 tggcgttttt ccataggctc cgccctcctg actgagttca cataaacaga cgctttttcg
     5941 gtgcatctgt gggagccggt ggctcaacca tgaatcagtc aggagtggcg aaacccgaca
     6001 ggacttaaag atcatcaccg tttccgatga atcgctccct cttgcgctct cctgttccaa
     6061 ccctgccgtt tcccggatac ctgttccgcc tttctccctt gcgggaagtg tggcgctttc
     6121 tcatagctca cactctggta tctcggctcg gtgtaggtcg ttcgctccaa gctgggctgt
     6181 aagcaagaac cccccgttca gcccgactgc tgcgccttat ccggtaactg ttcacttgag
     6241 tccaacccgg aaaagcacgc aaaacgccac tggcagcagc cattggtaac tgggagttcg
     6301 cagaggattt gtttagctaa acacgcggtt gctcttgaag tgtgcgccaa agtccggcta
     6361 cactggaagg acagatttgg ttgctgtgct ctgcgaaagc cagttaccac ggttaagcag
     6421 ttccccaact gacttaacct tcgatcaaac cacctcccca ggtggttttt tcgtttacag
     6481 ggcaaaagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctactg
     6541 aaccgcgatc cccgtcagtt cagaggagga cgatggtgcc accgttccac cctgaacatc
     6601 ccggatatag tttgcctgac atgcgaccag aagaaagcct gaaaaaatca atataaaaag
     6661 aaaaacaacc tttacctttt tcatatacct tccctgtatt taaaaacccc ggtattcatc
     6721 cctgaacacc ggaagtctgt atttcaaatc atccttgata acttttgctt accagttacc
     6781 atcccggtaa acaaaggata caaagtaatc aaatttacta atatcgatta catttttaaa
     6841 gtgtggctgt aatatcgaaa cccatgattt ttcaacatca aaccaaccat tattaatatt
     6901 atcctttaaa ggcatcccca gactttcaat gacagaacca tcatcaccga agtcttttga
     6961 gtattcacca cctttaaact cttcggtttt cttatcaaac caatgaatat gtaatttaag
     7021 ccccatattt acctcttaaa gatatttttt aatgtttcgt tttggatccg gccctttaac
     7081 ctgcttaccc gtttttggat cgaatgcccc gaggtgttcg ccatcactgg cgcggtaccc
     7141 ttcaagctca ccgtgctggg aatcccattc ataaatttta cgctttttat caccatacca
     7201 tcgggcccgc ttaccaccac caccttgttt aggggtttta ggtttaccct ctttcaactc
     7261 tcccaacccc ttaatatctt cagtcttggg atcaggaaaa taatcatggc cgtaatcttt
     7321 agttccctta cgaggttttt tcttttcctc atttaattta ttttctgcat ccttcgcttt
     7381 tttctccttt tgtttccggc tctccatcgc cccggaaagc gcagccttat ccctggataa
     7441 ggattcattc atttcgttta aagatgtctg ggcagctttt aatttctcat tctgattctg
     7501 aatatcctta tcaagatagc gaacctgatc ctgccacccg gagccatatt catgaggcgg
     7561 gttataagtc acaaaatcat ctttatttgc ctctgcctct tttacctttt tatcggcttc
     7621 ctgaacagca gcccttgcac cggggatcgc cttctctgtc gatgcaatgc gactgtttaa
     7681 ggtcgcaata tttttatctt cagcatccag ctcagctttc gctttatcat actctctttt
     7741 cagcccctct tccgggtgag cagcgtccca tgcctgctgg cgacgctttt cttcctccag
     7801 acgctgtttt acctgtgccg gagtaagaac atccgtcacc gacacataga ccggtttctg
     7861 tccgctctct ttcgggaaac gaataacggc ttcacgggag ttaccaccgg ccgtaaaacc
     7921 agccggacgt gaatcacctt tttcagcaat aatgcctttt ggcggggctt tcgcggccgg
     7981 aacaccttta ggtacgctca cctgcagaga cgggagaccc ggaatcgaca cactgaatac
     8041 ccccggacgt tttgtcggtt tcgcatccac cacaggaaca ctcattggcc ggccggtgac
     8101 aaccgcaata tgctgccgct cgtccttcac aatatccgcc acacgtttag tgacgctgac
     8161 cgtcgcctgg tccagcggca gggagctgac cggcgtctcc gttaccgtgt ctgccggcaa
     8221 tgacgtcacg atttttgaca tcattttcgg atcatctttt gctatctcag aaggcagcac
     8281 tccgtaaatc gcaatccccc acagaccaaa cttaaacgga cctttcaggg cagccagcac
     8341 atcagcaaca gcggccgaca acgcatcgcc ggaaacggat aaagccagtc cttcagcccc
     8401 cggagtggcc aaggcaggca gaccgaaggc catcgcggtg gccgaagact gtccgccacc
     8461 agagctcccg ctatgattgc cgctgttacc gccattacca ccgggtttac tcccgccgtt
     8521 accaaactcc cccgggttat agttatgaat atccccgtta ggtgtatgcg tcgtacccca
     8581 gcccggcccg ctgtttggat ccgtaccacc acctgatgaa gggccacctt tacctgatgt
     8641 accgttcaca ttcccactgg cctgaccacc attgtgtccc agacctgaat tacccggacc
     8701 tcgtccgtct ccgccactca tatacttttc ctctttgact tttaaaacaa taaactaaaa
     8761 taaaatactg tacatataac cactggtttt atatacagta taaaaattac gctgccttgt
     8821 ttttcatgtc aagtctgtaa atttgcgttt ttgtgaaaat gatcaaaaaa acagccactc
     8881 acaccatgcg caatcccccc cagatgcaac aaaaaccagc acaaacggcg ccgttctccg
     8941 gcctcagtat gttttactga aatcattata tgagatacca gaaagccccc tccgggacag
     9001 gaaaagaaac ggggggtctg gttcgggttg ttcggtcact gaacacggtc agaaactgat
     9061 gataagatag cctgcggata tataactcaa tgagaaaaaa gaattaaagg taaggagacg
     9121 ctcatgagac gttccggcag caaactgtgt cttatcgcca tgataacagc gacagcaact
     9181 ctcactgcct gtgctccaaa gggcagcgtg gaacagcata cccggcatta cgtatatgct
     9241 tcagatgacg gttttgatcc caatttttcc acccagaaag ctgacacaac acga
//
