LOCUS       CP088726               16311 bp    DNA     circular BCT 09-DEC-2021
DEFINITION  Escherichia coli strain B16EC1113 plasmid pB16EC1113-1, complete
            sequence.
ACCESSION   CP088726
VERSION     CP088726.1
DBLINK      BioProject: PRJNA782071
            BioSample: SAMN23391579
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 16311)
  AUTHORS   Yoon,E.-J., Choi,Y.J., Kim,D., Won,D., Choi,J.R. and Jeong,S.H.
  TITLE     Chromosomal integration and amplification of group 9 blaCTX-M genes
            in Escherichia coli expand the spectrum of resistance under
            antimicrobial pressure
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 16311)
  AUTHORS   Yoon,E.-J., Choi,Y.J., Kim,D., Won,D., Choi,J.R. and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-NOV-2021) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, Gangnam Severance Hospital,
            Yonsei, Seoul 06273, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: other: SMRTLink v. v9.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 105x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 12/02/2021 14:07:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 5.3
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,349
            CDSs (total)                      :: 5,227
            Genes (coding)                    :: 4,969
            CDSs (with protein)               :: 4,969
            Genes (RNA)                       :: 122
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 94
            ncRNAs                            :: 6
            Pseudo Genes (total)              :: 258
            CDSs (without protein)            :: 258
            Pseudo Genes (ambiguous residues) :: 0 of 258
            Pseudo Genes (frameshifted)       :: 105 of 258
            Pseudo Genes (incomplete)         :: 172 of 258
            Pseudo Genes (internal stop)      :: 45 of 258
            Pseudo Genes (multiple problems)  :: 54 of 258
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..16311
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="B16EC1113"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:562"
                     /plasmid="pB16EC1113-1"
                     /geo_loc_name="South Korea"
                     /lat_lon="37.68 N 126.77 E"
                     /collection_date="2016"
                     /collected_by="Kor-GLASS"
     gene            84..557
                     /locus_tag="LQR03_25690"
     CDS             84..557
                     /locus_tag="LQR03_25690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UGI68960.1"
                     /translation="MKYDDVSELMIKREHNILIVGNSASHIDKFFKGYSIPGSKYYDFT
                     QINSDSDVERNEDAVSFIRDAMNSEEQTIIFNCAGWPDLGGGSAVSQFAMMVRKFGKQL
                     IVAVSEKDAIKLKDNFDIIGMLSYGKENFIAMSHTKNELTGGKRRYRIKNGCK"
                     /name="hypothetical protein"
     gene            804..953
                     /locus_tag="LQR03_25695"
     CDS             804..953
                     /locus_tag="LQR03_25695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001300273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Hok family toxin"
                     /protein_id="UGI68961.1"
                     /translation="MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAY
                     EARK"
                     /name="type I toxin-antitoxin system Hok family toxin"
     gene            1238..1486
                     /gene="repA"
                     /locus_tag="LQR03_25700"
     CDS             1238..1486
                     /gene="repA"
                     /locus_tag="LQR03_25700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000083832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication regulatory protein RepA"
                     /protein_id="UGI68962.1"
                     /translation="MSQTENAVTSSSGTKRAYRKGNPLTLAERQQASLARKRATHKELR
                     VFIPAALKAQLQVMCEAEGVTQAEMIAELIKQKSAFS"
                     /name="repA"
     gene            1731..1805
                     /gene="tap"
                     /locus_tag="LQR03_25705"
     CDS             1731..1805
                     /gene="tap"
                     /locus_tag="LQR03_25705"
                     /inference="COORDINATES: protein motif:HMM:TIGR03475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RepA leader peptide Tap"
                     /protein_id="UGI68971.1"
                     /translation="MPGKVQDFFLCSLLLRIVSAGWCD"
                     /name="tap"
     gene            1798..2655
                     /gene="repA"
                     /locus_tag="LQR03_25710"
     CDS             1798..2655
                     /gene="repA"
                     /locus_tag="LQR03_25710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="incFII family plasmid replication initiator RepA"
                     /protein_id="UGI68963.1"
                     /translation="MTDLQQTYYRQVKNPNPVFTPRKGAGTLKFCEKLMEKAVGFTSRF
                     DFAIHVAHARSRGLRRRMPPVLRRRAIDALLQGLCFHYDPLANRVQCSITTLAIECGLA
                     TESAAGKLSITRATRALTFLSELGLITYQTEYDPLIGCYIPTDITFTSALFAALDVSEE
                     AAAAARRSRVVWENKQRKKQGLDTLGMDELIAKAWRFVRERFRSYQTELKSRGIKRARA
                     RRDADRERQDIVTLVKRQLTREIAEGRFTANREAVKREVERRVKERMILSRNRNYSRLA
                     TASP"
                     /name="repA"
     gene            3354..3512
                     /locus_tag="LQR03_25715"
     CDS             3354..3512
                     /locus_tag="LQR03_25715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001700046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UGI68964.1"
                     /translation="MAENGYGLAGLGMGKVKSINQYRLTPGFGGFTPVPYATTECRLPC
                     RWRGISW"
                     /name="hypothetical protein"
     gene            3567..3836
                     /locus_tag="LQR03_25720"
     CDS             3567..3836
                     /locus_tag="LQR03_25720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000079945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UGI68965.1"
                     /translation="MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQH
                     NTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRDEISRKVAGK"
                     /name="hypothetical protein"
     gene            3833..4114
                     /locus_tag="LQR03_25725"
     CDS             3833..4114
                     /locus_tag="LQR03_25725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001585073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="UGI68966.1"
                     /translation="MMEIFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAG
                     QPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVYILRVLHTAQKWP"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            4160..5008
                     /locus_tag="LQR03_25730"
     CDS             4160..5008
                     /locus_tag="LQR03_25730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001057990.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exonuclease"
                     /protein_id="UGI68967.1"
                     /translation="MNNDELVTRRAQAIAEDRCFSKGRLRDEFRMKPAPGAEPVKWYKN
                     TYGGRFAVYRIADCVPMREKRPLTSKQQLAGQRLSVLSRLNSTSGRMARQAYDWLSLAP
                     LFLDTETTGLDNTAEALEIGLTDAAGQVVFETRLKPTVAIGAQAAAVHGISEQALCGAP
                     SWTDMARQLRHAIGDRPVIIFNARFDIRILKQTAAAHSDPADWLEEMTVYCAMELAAGY
                     YGATNRYGTISLASAASQAGLTWEGLAHSAIVDARMAAGVVNAIAAYHLELLQEQARLK
                     I"
                     /name="3'-5' exonuclease"
     gene            5125..5607
                     /locus_tag="LQR03_25735"
     CDS             5125..5607
                     /locus_tag="LQR03_25735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001402899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UGI68968.1"
                     /translation="MRNKTREAMRLFLGGRCYTAEKLEKDYLAEVANYSNDRWEAPQRA
                     ARLAASVKRYKTSEMLRFIFATIAYDPDPDLTPLTVRRLCKALFGRTGSQWLVVEVFGE
                     KGRQHRSADSNPEMVEKMAARYRHAAELHWSATLAEIERVKRLYQTKIKKSKKEVG"
                     /name="hypothetical protein"
     gene            complement(5621..6646)
                     /gene="lamB"
                     /locus_tag="LQR03_25740"
                     /pseudo=""
     CDS             complement(5621..6646)
                     /gene="lamB"
                     /locus_tag="LQR03_25740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_709883.2"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="maltoporin LamB"
                     /name="lamB"
     gene            complement(6695..7102)
                     /locus_tag="LQR03_25745"
                     /pseudo=""
     CDS             complement(6695..7102)
                     /locus_tag="LQR03_25745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491235.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
                     /name="IS5 family transposase"
     gene            complement(7182..8057)
                     /locus_tag="LQR03_25750"
     CDS             complement(7182..8057)
                     /locus_tag="LQR03_25750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032492044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class A extended-spectrum beta-lactamase
                     CTX-M-27"
                     /protein_id="UGI68969.1"
                     /translation="MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSG
                     GRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPAD
                     LVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETF
                     RLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAA
                     SIRAGLPTSWTVGDKTGSGGYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLA
                     SAARIIAEGL"
                     /name="class A extended-spectrum beta-lactamase CTX-M-27"
     gene            complement(8307..9570)
                     /locus_tag="LQR03_25755"
                     /pseudo=""
     CDS             complement(8307..9570)
                     /locus_tag="LQR03_25755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_031587700.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS1380-like element ISEcp1 family transposase"
                     /name="IS1380-like element ISEcp1 family transposase"
     gene            complement(9914..11101)
                     /locus_tag="LQR03_25760"
     CDS             complement(9914..11101)
                     /locus_tag="LQR03_25760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005227443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="UGI68970.1"
                     /translation="MLLGSQFVFNIGFYAVVPFLALFLRDDMLLSGGLIGLILGLRTFS
                     QQGMFILGGTLADRYGAKAIILAGCVVRVAGFLLLACGASLWPIILGACLTGVGGALFS
                     PSIEALLARAGTHSQANGKRSRAEWFALFAVCGELGAVIGPVAGGVLSGIGFRHIALAG
                     AGIFLLALAVLFFGLPADGHTTTTRRRVPWWTPLRQPRFVAFILAYSSWLLSYNQLYLA
                     LPVEIQRSGGREQDLAPLFMLASLLIITLQLPLARFARRMGAVRILPVGFLLLSASFAS
                     VALFAAAPPAESWLRLMPAAGFVTLLTLGQMLLVPAAKDLIPLFAEESTLGAHYGALAT
                     AGGCAVLAGNLLLGHLLDQALIPSPQAVYPWLLLALFPLCSAVALRAICRPLAAT"
                     /name="MFS transporter"
     gene            complement(11158..11919)
                     /locus_tag="LQR03_25765"
     CDS             complement(11158..11919)
                     /locus_tag="LQR03_25765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000020503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="UGI68955.1"
                     /translation="MSICAENITWKAGKKVIVNNVSLRVPRGETVGLLGPNGCGKSSLL
                     RVLAGLRRPDAGRVTLDGQDIARMAKKQLARRVAYVEQHGMTEANMRVRDVVRLGRIPH
                     HSPFSNWSAQDDEAIAAALQRVAMLEKSEQGWLSLSGGERQRVHIARALAQSPSEILLD
                     EPTNHLDIHHQMQLMQLISELPVTSIVAIHDLNHAAMFCDSLIVMQQGQILASGTPEEI
                     LSEALLWDVFRVKTKIEISPYHGKKHIHFIV"
                     /name="ABC transporter ATP-binding protein"
     gene            complement(11919..12956)
                     /locus_tag="LQR03_25770"
     CDS             complement(11919..12956)
                     /locus_tag="LQR03_25770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005227440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="UGI68956.1"
                     /translation="MSVAAIETRRSILLTGWCVLAAIVLALVIAVGVSVGELAIPLQNV
                     FYAISNRTGLTAEPLNRIYESVIWDFRLSRALVAACCGAGLAICGVVLQSLLKNALAEP
                     YVLGVSAGASTGAVSIVVLGLGAGAISLSAGAFAGAFAAFAFVALLTNGARGGNERTIL
                     AGVAASQLFNAITAYTISTSASAQQARDVMFWLLGSFSGVRWPEFQLVIVVVLAGLAVC
                     LWYARALDAFTFGDDAAASLGIAVPRVRLILFTTAALITATIVSMAGSIGFVGLVVPHV
                     MRFFFGPLHRTLLIASALAGAILMVLADIASRLLIAPQSLPVGVVTALVGVPFFAVIIY
                     RSRNK"
                     /name="iron ABC transporter permease"
     gene            complement(12956..13954)
                     /locus_tag="LQR03_25775"
     CDS             complement(12956..13954)
                     /locus_tag="LQR03_25775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005227439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="UGI68957.1"
                     /translation="MKKILCALGLMFTAVSSALATTYPLTIENCGYQETFTRPPERVVA
                     LGQNTVEILLLLGLQKQVVASAFWPTSVLPQLAEQNAKIKTLTVEIPSLESVLAQNPDF
                     VPAQLPLLLGPESKVARREDLATVGVNSYVSPGMCATKKATGDMYGSRQKLWDMTWLYQ
                     EISDFSRIFNVEDRGQALIADFKKREADLRQEFGKSKKDLSFVFWFSSASPSADAYVGG
                     KNSASGFIASVLGGHNAITSETEWPTVSWESIIAANPDVIVVASLDRNRWALDKAEEKI
                     KFLKSDPAVSQLEAVKKGHIVVMDGQAMNPTIRTLYGAEQVGEQLRKMGLN"
                     /name="ABC transporter substrate-binding protein"
     gene            complement(14104..14262)
                     /locus_tag="LQR03_25780"
                     /pseudo=""
     CDS             complement(14104..14262)
                     /locus_tag="LQR03_25780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611134.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="integrase core domain-containing protein"
                     /name="integrase core domain-containing protein"
     gene            complement(14305..14547)
                     /locus_tag="LQR03_25785"
                     /pseudo=""
     CDS             complement(14305..14547)
                     /locus_tag="LQR03_25785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_415892.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /name="recombinase family protein"
     gene            complement(14805..15155)
                     /locus_tag="LQR03_25790"
     CDS             complement(14805..15155)
                     /locus_tag="LQR03_25790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001630992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid partitioning/stability family protein"
                     /protein_id="UGI68958.1"
                     /translation="MDKRRTIAFKLNPDVNQTDKIVCDTLDSIPQGERSRLNRAALTAG
                     LALYRQDPRAPFLLCELLTKETTFSDIVNILRSLFPKEMADFNSSIVTQSSSQQEQKSD
                     EETKKNAMKLIN"
                     /name="plasmid partitioning/stability family protein"
     gene            complement(15158..16120)
                     /gene="parM"
                     /locus_tag="LQR03_25795"
                     /gene_synonym="stbA"
     CDS             complement(15158..16120)
                     /gene="parM"
                     /locus_tag="LQR03_25795"
                     /gene_synonym="stbA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000959884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid segregation protein ParM"
                     /protein_id="UGI68959.1"
                     /translation="MLVFIDDGSTNIKLQWQESDGTIKQHISPNSFKREWAVSFGDKKV
                     FNYTLNGEQYSFDPISPDAVVTTNIAWQYSDVNVVAVHHALLTSGLPVSEVDIVCTLPL
                     TEYYDRNNQPNTENIERKKANFRKKIILNGGDTFTIKDVKVMPESIPAGYEALQELDEL
                     DSLLIIDLGGTTLDISQVMGKLSGISKIYGDSSLGVSLVTSAVKDALSLARTKGSSYLA
                     DDIIIHRKDNNYLKQRINDENKISIVTEAMNEALRKLEQRVLNTLNEFSGYTHVMVIGG
                     GAELICDAVKKHTQIRDERFFKTNNSQYDLVNGMYLIGN"
                     /name="parM"
     ARG             complement(7186..8057)
                     /name="blaCTX-M-27"
                     /gene="blaCTX-M-27"
                     /gene_name="extended-spectrum class A beta-lactamase
                     CTX-M-27"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     Typing          1829..2655
                     /name="IncFIA"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.034"
                     /coverage="97.0"
                     /evalue="0.0"
ORIGIN
        1 tgtaataaaa agcgggaaat ggtggtcaca gagtaaattc cggaaccacc tgtacccaaa
       61 ctttatataa taatggtgaa tatatgaaat atgatgatgt atcagaattg atgattaagc
      121 gtgaacacaa tattcttatt gttgggaact ctgcctccca cattgataag ttttttaagg
      181 ggtattctat accaggttct aaatattatg atttcactca gattaacagt gattcagatg
      241 tagagagaaa tgaggatgct gtctccttta tcagggatgc aatgaatagt gaagagcaga
      301 caatcatttt taattgtgct gggtggcctg atttaggtgg tggatcagca gtatcacagt
      361 ttgcaatgat ggtcagaaaa tttggtaaac aacttattgt cgctgtaagt gaaaaggatg
      421 ccatcaaatt aaaagacaac tttgatatta ttgggatgtt gtcatatggt aaagaaaatt
      481 ttattgccat gagtcatacg aaaaacgagt taactggagg aaaacgtcgg taccggatta
      541 aaaatggatg taaataaaaa gcatacttat tggctggagt gacgccttcg tgcttctgta
      601 gtaaaaagcg ggcaatgcag gtaatagtca gcaacaggga atgtggtatt atcgcggcgg
      661 gtgtctgagc ctttctggtt caggcaagac gcaggtacca gaaatgcaaa gaccccactt
      721 gttaatccat taactcgtga ggtctgcatg aagtacattg cactactgat tgtagcctct
      781 tccttgcaga gaggtcaaag tttatgacga agtatgccct tatcgggttg ctcgccgtgt
      841 gcgccacggt gttgtgtttt tcactgatat tcagggaacg gttatgtgag ctgaatattc
      901 acaggggaaa tacagtggtg caggtaactc tggcctacga agcacggaag taaactgccg
      961 ggcggggacg gaagtccccg ctttccggaa gtgtgaggta tttcaggggc agacacccga
     1021 catgccagaa acagccggtc ccgcccgggg ccggctcccg ggttaaggca tttcctgttt
     1081 tttcagccat ttcgcaacaa aaatcacatt aaacaacagt aatccccgtt gatttgtgcg
     1141 ccaacacaga tcttcgtcac aattctcaag tcgctgattt caaaaaactg tagtatcctc
     1201 tgcgaaacga tccctgtttg agtattgagg aggcgagatg tcgcagacag aaaatgcagt
     1261 gacttcctca tcaggtacaa agcgagcata cagaaaaggt aatcctctga cgcttgcaga
     1321 acgtcagcag gcatccctgg caagaaaacg agctacacat aaagaactca gagtgttcat
     1381 tcctgctgcg ttaaaagcgc aattgcaggt gatgtgtgaa gctgagggcg ttacccaggc
     1441 tgagatgatt gccgaactga taaagcagaa gagtgctttt agctaactaa aatgtagcga
     1501 catcacattc ttgcctgttt ctggtgtgcg tgatagattg ctgatcgttt aaggaatttt
     1561 gtggctggcc acgccgtaag gtggcaggga actggttctg atgtggattt acaggagcca
     1621 gaaaagtgaa aaccccgata atcttcgaca agtttggcga ctgagaagat taccggggcc
     1681 atctaaaaac cgtatagcca acaattcagc tatgcgggga gtatagttat atgcccggaa
     1741 aagttcaaga cttctttctg tgctcactcc ttctgcgcat tgtaagtgca ggatggtgtg
     1801 actgatcttc aacaaacgta ttaccgccag gtaaagaacc cgaatccggt gtttacaccc
     1861 cgtaaaggtg ccggaacgct gaagttctgc gaaaaactga tggaaaaggc ggtgggcttc
     1921 acttcccgtt ttgatttcgc cattcatgtg gcgcatgccc gttcgcgtgg tctgcgtcga
     1981 cgcatgccac cggtgctgcg tcgacgggct attgatgcgc tcctgcaggg gctgtgtttc
     2041 cactatgacc cgctggccaa ccgcgtccag tgctccatca ccacgctggc cattgagtgc
     2101 ggactggcga cggagtctgc tgccggaaaa ctctccatca cccgtgccac ccgggccctg
     2161 acgttcctgt cagagctggg actgattacc taccagacgg aatatgaccc gcttatcggg
     2221 tgctacattc cgaccgatat cacgttcaca tctgcactgt ttgctgccct cgatgtatca
     2281 gaggaggcag cggccgccgc gcgccgcagc cgtgtggtat gggaaaacaa acaacgcaaa
     2341 aagcaggggc tggataccct gggcatggat gaactgatag cgaaagcctg gcgttttgtt
     2401 cgtgagcgtt ttcgcagtta tcagacagag cttaagtccc ggggaataaa gcgtgcccgt
     2461 gcgcgtcgtg atgcggacag ggaacgtcag gatattgtca ccctggtgaa acggcagctg
     2521 acgcgcgaaa tcgcggaagg gcgcttcact gccaatcgtg aggcggtaaa acgcgaagtt
     2581 gagcgtcgtg tgaaggagcg catgattctg tcacgtaacc gtaattacag ccggctggcc
     2641 acagcttccc cctgaaagtg acctcctctg aataatccgg cccgcgctgg aggcattcgc
     2701 acgcctgaag cccgtcgatg cacaaaaaaa cagcaccaca tacaaaaaac aacctcatca
     2761 tccagcttct ggtgcatccg gccccccctg ttttcgatac aaaacacgcc tcacagacgg
     2821 ggaattttgc ttatccacat taaactgcaa gggacttccc cataaggtta caaccgttca
     2881 tgtcataaag cgccagccgc cagtcttaca gggtgcaatg tatcttttaa acacctgttt
     2941 atatctcctt taaactactt aattacattc atttaaaaag aaaacctatt cactgcctgt
     3001 cctgtggaca gacagatatg cacctcccac cgcaagcggc gggccccgac cggagccatt
     3061 ttagttacaa cactcaaata caagcaccgg aaaaccccag tccagcgcag aactgaaacc
     3121 acaaagcccc tcctcataac tgaaaagcgg ccccgccccg gcccgaaggg ccggaacaga
     3181 gtcgctttta attatgaatg ttgtaactac atcatcatcg ctgtcagtct tctggctgga
     3241 agttctcagt acacgctcgt aagcggtcct gacggcccgc taacgcggag atacgccccg
     3301 acttcgggta aaccctcgtc gggaccactc cgaccgcgca cagaagctct atcatggctg
     3361 aaaacgggta tggcttagca ggactgggga tgggtaaggt gaaatctatc aatcagtacc
     3421 ggcttacgcc gggcttcggc ggttttactc ctgtgccata tgcaacaacg gagtgccgcc
     3481 ttccatgccg ctggcgcggc atatcctggt gacgatatct gaatcgttat atactgtgta
     3541 tatacgtagt aatgacgagg tgataaatgg cacaggttaa tatgagttta agaatcgacg
     3601 ctgaactgaa ggatgctttt atggccgctg caaaaagcat ggaccgtaat ggctctcagt
     3661 taattcggga ttttatgcgc cagaccgttg aacggcagca taatacttgg ttccgtgacc
     3721 aggttgcggc aggacgtcag caactcgaac gcggcgatgt gcttccccat gatatggtcg
     3781 aatcctccgc tactgcatgg cgggatgaaa taagcaggaa ggtcgccggt aaatgatgga
     3841 gatattctgg accatactgg ccagccagga caggaagcgc attcgtgagt atattgcgga
     3901 gcagaacctg atggctgcca ttgaactgga cgaacggatt ggttattcag ccagcagcct
     3961 ggccgggcag ccgtataaag gccgcaacgg tcgtgtggaa ggtacccggg aactggttat
     4021 tcacccgcat tttgttctgg tttatgaggt cgacagccag tggggaaaag tgtatatcct
     4081 gcgagtattg catactgcac agaagtggcc atagaggggc tgtccggata taaaaacgtc
     4141 tgacggagat gcaagaacca tgaataatga tgagctggtc accagacgtg cgcaggcgat
     4201 tgccgaagac aggtgtttct cgaaaggacg tctgcgcgat gaattcagaa tgaagccagc
     4261 ccccggtgct gagccggtta agtggtataa aaatacttat ggtggcaggt tcgctgtata
     4321 ccgaattgca gactgtgttc cgatgcgtga gaaacgccct ctgacgagta aacaacagct
     4381 ggctggccag cggctttccg ttttatcccg gctaaacagc accagtggcc ggatggcacg
     4441 gcaggcatat gactggctga gtctggcacc actctttctg gatactgaaa cgacaggact
     4501 ggataatacc gcggaagccc tggaaatcgg cctgaccgat gcggccggtc aggtggtatt
     4561 tgaaaccagg ctgaagccca cggtcgccat cggggcgcag gccgccgccg tgcatggtat
     4621 cagtgagcag gctctttgcg gcgcaccatc atggacagat atggcgcggc aactgcggca
     4681 tgcaatcgga gatcgaccag taattatctt taatgcccgg ttcgacatcc gcattctgaa
     4741 acagactgcg gccgcacata gcgatccggc tgactggctg gaagaaatga cggtatattg
     4801 tgcgatggag ctggctgcag gatattatgg ggccaccaac cgctatggca cgatttcact
     4861 ggccagtgct gccagccagg ccggactgac ctgggaaggg ctggcacact cagcgatcgt
     4921 cgacgcacgg atggcggcag gggtggtaaa cgctattgct gcatatcatc tggaactgct
     4981 gcaggaacag gcacggctga aaatctgacc gcctggcctg tataccgcaa tcatttacgt
     5041 tatccagacg taaatccgcc gcttgttact gtcagcatgt taatgctaat gtatgcgtac
     5101 attagcatta atgagggatg atatgtgaga aataaaacca gggaggccat gcggcttttt
     5161 ttaggcggca ggtgctacac ggctgaaaaa cttgaaaagg attatctggc tgaagtggct
     5221 aattacagta acgaccgctg ggaagcaccg caacgtgccg cacgcctggc tgccagcgta
     5281 aagcgttaca agacatcaga aatgctgcgc tttatttttg ctaccattgc ctatgatccc
     5341 gatccagatt taaccccgct gactgtgaga cgtttgtgca aggcattgtt cggcagaacc
     5401 ggaagccagt ggctggttgt tgaagttttt ggggagaagg ggcgtcagca ccgcagcgcg
     5461 gacagcaatc cggagatggt ggaaaaaatg gctgccagat atcgtcatgc cgccgaacta
     5521 cactggtccg caacgctggc agaaattgaa cgggtaaagc ggctttatca gacgaaaatt
     5581 aagaaatcca aaaaagaagt gggttgactg ccattgttat tctctgggat tcgacgttgt
     5641 cgtagccgat ttccatcacg gtgctcatga ttggcgtcca cttgtacatc gggcgaatac
     5701 cgacggtcca ccacttggtg ccgttgtcgt tatcccagtt gatatcctgg tacataccca
     5761 cgtacatcat gtcccagttg tcgcccatgg agatcgctcc gtggtcgagg atacgcagca
     5821 tgtgaccgtt gttgttgata ttgtaggcaa atttttcgtt atcaaacgcg acgccagaac
     5881 cctgcgacag acctttaccc tgcgaggtca tcgagtcagt agcgtactga acaacaaact
     5941 tgttaaagcc cttcaggaca ctctgagtat gttcagcagt gaacaaccag ccgtctttcg
     6001 atgcgccatc aaccagacga tagttatcac gcaggttggc acgaccgtag tcgacaccca
     6061 gttctaatgt gccgcccgga ttgatttcca tctgcgctaa acgcacatcg aaaacgtcgt
     6121 tcgcggtttc gttggtatag tcataaatat tgttgctggc gaaagaggaa gaaccacctg
     6181 cttcagagga gcgggttgct gccagagaga gtttaccgaa gccaacatcg atgttttcca
     6241 gaccggcacc aggaccagaa atatcccagt agtagaagtc gatcatatga acgtcatgac
     6301 gttggtagaa gcgcttacct gcccagatgg tggagcctgg cagccattcg atcaggtttt
     6361 taccctgcac gtttgcttca cggaaggccg gatcggtagc ttcccagtca ttctgttgtg
     6421 cgacggaata ggccacgtta gtgtcgaaat agaagctctt atcgccctct ttccacactt
     6481 cctgacccaa ttttaattca gcataagttt cacattcgtt gccaagacgg tatttacttt
     6541 gagcaccggt agtctggaaa cactgttgtt caccgccgct acctgtccag ccaataccgg
     6601 aacgtgcata gccgtggaaa tcaacagcca ttgcctgagc agacattacg cccgctgcga
     6661 cggcaaccgc cagaggaagt ttgcgcagag taatcttgac tttccactcg ccttcaccga
     6721 agaccttcag cccggtggaa tcaattacca ggtgtgcgat ttcaccccgg gtgggcgttt
     6781 tgaaactgat attaaccgac tttgcccgcc tgctgacaca gctgtaatcc gggcagcgta
     6841 gcggaacgtt catcagagaa aaaatggaat caataaagcc ctgcgcagcg cgcagggtca
     6901 gcctgaatac gcgtttaatg accagcacag tcgtgatggc aaggtcagaa tagcgctgag
     6961 gtctgcctcg tgaagaaggt gttgctgact cataccaggc ctgaatagct tcatcatcca
     7021 gccagaaagt tatggagcca cggttgatga gggctttatt gtaggtgggc cagttggtga
     7081 ttttgaactt ttgctttgcc acggaacggt ctgcgttgtc gggaagatac gtgatctgat
     7141 ccttcaactc agcaaaagtt cgatttattc aacaaaacca gttacagccc ttcggcgatg
     7201 attctcgccg ctgaagccag cacatcgcgg cggctctctg cgttctgttg cggctgggta
     7261 aaataggtca ccagaaccag cggcgcacga ccctgcggcc agatcaccgc aatatcattg
     7321 gtggtgccgt agccgccgct gccggtctta tcacccacag tccacgacgt cggtaagccg
     7381 gcccgaatgc tggctgcgcc ggtcgtattg cctttgagcc acgtcaccaa ctgcgcccgc
     7441 tgggtttcgc ccagcgcatg acccagcgta agctgacgca acgtctgcgc catcgcccgc
     7501 ggcgtggtgg tgtctctcgg gtcgccggga atggcggtat tcagcgtagg ttcagtgcga
     7561 tccagacgaa acgtctcatc gccgatcgcg cgggcaaaag ccgtcacgcc tcccgggcca
     7621 ccgagctggg caatcaattt gttcatggcg gtattgtcgc tgtactgcaa cgcggccgcg
     7681 ctcagttctg ccagcgtcat tgtgccgttg acgtgttttt cggcaatcgg attgtagtta
     7741 accagatcgg caggcttgat ctcgacaggc tgattaagca gctgcttttg cgtttcactc
     7801 tgcttaagca ccgccgcggc cgccataact ttactggtac tgcacattgg aaagcgttca
     7861 tcaccgcgat aaagcacctg cgtattatct gcggtatcga tgagcgcgac gcccagccgc
     7921 cctccgctgc ttttctccag cgccgccagc ttttgctgca ccgcactcgt ctgcgcataa
     7981 agcggcgcgc tgcccagcag cagcggaatg cacgccgccg ccgcgaacat catccgttgc
     8041 actctctttg tcaccatctc aaactcccaa tacggtcaat ccgtgttaca tcagtattcc
     8101 ctaaattcca cgtgtgtttt ttattagctt caaaaatcac tatttcacga agaatttaga
     8161 ctgcttctca cacattgtaa cattatttac aaccaccttt caatcatttt tgataaatca
     8221 ttgatttcat ctttgctgca atgatactta ataaactctg caagttatcc acagagcaac
     8281 actcaatttt attgatgata ttcttattat accagacatt tttcatacac tcccttgtac
     8341 ggatagtttt ccgacaactt catgattaca tatcttgcgg ttttgattat ttttgctgca
     8401 agaaatacat acttcaaacg aaaggtcttt atttgctgtc tgtattctga agagtccaag
     8461 gaatcaaact tgaacaacaa aaataggtta tatgaaagca tcatcatttg aaacacggct
     8521 tcattcgccc aaaatgactt tagcaagaga tgacccaccg ccatgtcgta tttggcttct
     8581 ttgatatagt tttcagcatt accacgcttt tcatagtata taactacttt ttcagaaagc
     8641 aaggtagtat ttgttacaaa gaaaaagtag tcgtattcgg aaccttctaa aagtgataat
     8701 tgtgctcttt ctttttctgg tttcagtacg cgagatacga caaatcttct gtctttttcc
     8761 catttaacta attttgtata cagttctgta gtttctctac cttcttctcc tttaacgaat
     8821 acaattgatg aattcgttgc ttgtgaggtg agtgtagaat aacttttggc tttaattaaa
     8881 tatttgcatc caagagattc tatcgtttcg ataatttttt catcaaagta gccactatcc
     8941 attcgaaata aaatttctaa atcgtctgat ttgatgttag caacaatttc tttgatcatt
     9001 tccgcagcac cgtttgcagt gtaagtattg ccacttctta caaatccggt aacatatgct
     9061 tttaattcgt cgcaaaatgc aaattggata ttgtagcatc ggtttcccag tttcttagga
     9121 ttatatcctt ttgacgcacc ttcttgatga ccttctacgt taattacact actatcaata
     9181 tcaatcgtaa tggatgtcaa tttactttta gtgagcagtt tttttaaaga ctttaaaatt
     9241 aatgtctcta aacatttggg ttgtcttgaa gttgaagttt cctagaaacc gtgacactgt
     9301 ttcaggttct tttacggaaa tatcaaactc gttgacgagg ggatcatttt gaagtagctt
     9361 tagacgttct aacttatcaa tgccaatgaa gtgaccgcag agcatggtct ttatatgatt
     9421 catcttgatt ttatttgttg agtcattatc aaatacgagg tcattttcaa taaaatcaaa
     9481 aatcccattg ctttttgcat tctcaaggag cagaaaaaga cctgcatttg atgttagatt
     9541 cttagctttg aaatcaattt tattaatcat aattagaacc cctttttact acttttctta
     9601 ctattatttt accatatatc gagtcataaa agctgataat ttaacatatt tttgagcact
     9661 tttctttcac ccaatgggtg aaagctgaat ttcgaaggaa tgcatattta tcaaggcttt
     9721 gattatgctt tttgaagtac tgacgtagaa tctaggtaat gctaatgtat gcatacatta
     9781 gcattaatga tggtgcgtta aacgtacaat aattttcgat atccaaactg accccaggat
     9841 ctttgctaaa ggattagctg aaaatatgga tactagctgt tcacttccag agcgggctgt
     9901 tacccgctct gcgtcatgtt gccgccagcg ggcgacagat cgcccgcagg gcgacggcgc
     9961 tgcacagcgg aaacagcgcc agcagaagcc agggataaac cgcctgcggc gacggaatga
    10021 gcgcctggtc aagtaaatga ccgagcagta aattcccggc taacaccgcg caccctcctg
    10081 cagtggcgag cgctccgtag tgggcaccca gcgtcgactc ctcggcgaac agcgggatca
    10141 gatccttggc tgcgggcact aacagcatct ggccgagggt gagcagcgtg acaaaaccag
    10201 ccgccggcat taaccgcagc caactttcgg cgggtggggc ggcggcgaat aacgccacgc
    10261 tggcaaagga agccgacagc agcagaaagc ccaccggcag gatgcgcacg gcgcccattc
    10321 gccgggcgaa gcgggcgaga gggagctgga gggtgataat caacagcgag gccagcataa
    10381 agagcggcgc cagatcctgc tcgcggccgc cggaacgttg gatctccacc ggcagggcga
    10441 ggtacagttg gttgtagctc aacagccatg agctgtaggc gagaataaac gcgacaaagc
    10501 gcggctggcg caaaggcgtc caccatggga ctcgtctgcg cgttgttgtc gtgtgcccgt
    10561 cggcgggcag accgaaaaag agcaccgcca gcgccagaag aaatattccc gcgccggcga
    10621 gggcgatatg ccgaaagccg atcccgctca gcacgcctcc ggccaccggg ccgatcaccg
    10681 ctcccagttc accgcatacc gcaaacagcg caaaccactc ggcgcggctg cgtttcccgt
    10741 tggcctggct gtgggtaccg gcccgcgcca gcagggcctc tatcgacggg gagaacaggg
    10801 cgccgccgac gccggtcagg caggcgccaa ggataatggg ccacagcgac gccccgcacg
    10861 ccagcaggag aaaaccggcg acgcgaacga cgcagccggc gagaatgatc gccttagcgc
    10921 catagcggtc ggccagcgtc ccgccgagga taaacatccc ctgttgggag aaggtacgca
    10981 gcccgaggat caggccgata agtccgcctg agagcagcat gtcgtcgcgc aggaagaggg
    11041 cgaggaaagg aacgaccgcg taaaagccaa tattaaaaac gaactggctt cccagtaaca
    11101 ccggaggcca gagggttgcc gcagggcgca gggagaaaag aggcatatcc gcccaaccta
    11161 aacgatgaaa tgaatgtgct ttttgccgtg gtaaggggag atctcgattt tggttttcac
    11221 ccggaaaacg tcccacagca gcgcttcgga caaaatctcc tccggcgtcc cgctggcgag
    11281 gatctgcccc tgctgcatca cgatcagcga atcgcagaac atcgcggcat ggttaagatc
    11341 gtgaatggcc acaatgctgg ttaccggcag ctcgctgatc aactgcatta actgcatctg
    11401 atggtgtata tccagatggt tggtcggctc atccagcagg atttcgctcg ggctctgcgc
    11461 cagcgcgcgg gcgatatgca cccgctgccg ctcgccgccg gagaggctta accatccctg
    11521 ttcgcttttc tccagcatcg ctacccgctg cagcgcggcg gcaatcgctt cgtcatcctg
    11581 agcgctccag tttgagaacg gagagtggtg gggaatgcgt cccaggcgca cgacgtcgcg
    11641 cacccgcata ttggcctcgg tcatgccgtg ttgctcgacg taagccacgc ggcgggcgag
    11701 ctgctttttc gccatccggg cgatatcctg gccgtcgagg gtgacgcgac ctgcatccgg
    11761 gcggcgcagg cccgccagaa cgcgcagcag cgaggatttg ccgcagccgt tgggccccag
    11821 cagtccgacc gtttcgccgc gcggcacccg cagcgagaca ttattgacga tgaccttttt
    11881 gcctgccttc caggtgatat tttcagcgca aatactcatc acttattcct tgagcggtag
    11941 ataatcacgg caaagaaagg caccccaacc agggcggtta ctaccccaac gggcagactt
    12001 tgcggggcaa tcagcaggcg cgacgcaatg tccgccagta ccatcaatat cgcccctgcc
    12061 agcgcgctgg cgatcagcaa agttcggtgc agtgggccaa agaagaaacg catcacgtgc
    12121 ggcaccacca ggccaacaaa gccgattgag ccggccatgc tgacgatggt ggcggtgatc
    12181 agcgccgcag tggtgaagag gatcaggcgc acgcgcggca cagcaatccc cagcgaggcg
    12241 gcggcatcgt cgccgaaggt gaacgcgtcc agcgcccggg cataccacag gcagaccgcc
    12301 agacccgcga gcaccaccac gatgaccaac tggaattcgg gccagcggac gccgctgaag
    12361 ctgcccagca gccagaacat cacatcgcgc gcctgctgcg cgctggcgga ggtgctgatg
    12421 gtataggccg tgatggcgtt aaataactgc gaggcggcga cgcccgcaag aatcgtacgc
    12481 tcattgccgc cgcgcgcgcc gttagtcagc aaggcgacaa aggcgaaggc ggcgaaggcc
    12541 ccggcaaagg cgcctgccga gagggaaatt gcgccagcac caaggcccag caccacgatc
    12601 gacaccgcgc cggtggaggc cccggcggag acgccgagga cgtagggttc ggcgagggca
    12661 ttcttcagca agctttgcag cacaacaccg cagatagcga ggccggcgcc gcagcaggcg
    12721 gcgaccagcg cgcggctgag gcggaaatcc cagataacgc tctcatagat acggttgagc
    12781 ggctcagcgg ttaagccggt tctgttgctg atagcataaa agacattctg cagcgggatg
    12841 gccagctcgc caacgctgac gcccacagcg atcaccagcg ccagcacgat cgctgccagt
    12901 acacaccagc cggtgagcag tatgctgcgg cgcgtctcaa tcgcggcgac gctcatcagt
    12961 tcagccccat ttttctcagc tgctcgccca cctgctccgc gccgtaaagc gtgcgaatgg
    13021 tcggattcat cgcctgaccg tccatgacca cgatatggcc ttttttcacc gcctccagct
    13081 ggctgacggc gggatcgctt ttgaggaatt tgatcttttc ctcggcctta tccagcgccc
    13141 agcggttacg atccaggctg gcgaccacga tcacatccgg gttggcggca ataatgctct
    13201 cccagctcac cgtgggccac tcggtttctg aggtaatcgc attatgtccg cccagcacgc
    13261 tggcgataaa tccggaggcg ctgtttttgc cgccgacata ggcatcggcc gaaggtgagg
    13321 cgctggagaa ccagaagacg aaggagagat cctttttgct tttaccaaac tcctggcgca
    13381 ggtcggcttc acgttttttg aaatcggcaa tcagcgcctg accacgatct tcgacgttga
    13441 aaatgcggga aaaatcgcta atttcctgat acagccaggt catatcccac agcttttgcc
    13501 ggctgccgta catatcgccg gtggcctttt tggtggcgca catccccggt gagacgtagc
    13561 tgttcacgcc gacggtggcg agatcttcac gcctggcgac tttgctttcc ggacccagca
    13621 gcagcggcaa ctgggcggga acgaaatcag gattttgcgc cagcaccgat tccaggctcg
    13681 gaatttccac cgtcaaggtt ttaatcttcg cgttttgctc agccagctgc ggtaaaacgc
    13741 tggtcggcca gaaggcgctg gcgaccacct gcttttgcag cccgagcagc agcagaattt
    13801 cgaccgtatt ttgccccagc gcgaccacgc gctccggcgg ccgggtgaag gtctcctgat
    13861 agccgcagtt ttcaatcgtc agggggtagg ttgttgccag cgcggaactg acggcggtga
    13921 acatcaagcc taacgcgcaa aggatcttct tcattaaacg ctatccttgt aaacaggcga
    13981 gtggatgacc agcaaatggg agtaatgcaa atgaaactca ttattggggc ggagttttat
    14041 ataatgccat atttacagtg tcaatgtgtt cttgccccct tatttccaga caggggttgt
    14101 atcttaagtt aacgttaccc actgacgtcg atattctcgc ggagagcgat aacccaacgc
    14161 actgtgcgga tggttttcat tgtaatgttc gatcgccact gcaagattat gcaatgccgt
    14221 tcttacattc ggtttcggca tgaacgcgat gtagtcttcc ttggggtccg cttggaaaac
    14281 ggaatcccac gctaagacta ttttctatac agtaacagtt tgctgtttcg ctctaactct
    14341 cagaattgtt tgccgtgtgg ttcggaattc cctggcaata gcacttatac ttgccccaga
    14401 cttaatgcgt tcgagtacct tctgtttttg ttcttcattt aataccggtg ggcgaccaaa
    14461 acgttttcct gcatcccgtg ctcttgctat ccctgaataa gttcgttcaa gtaaaagatc
    14521 tcgttcaaat tcagcgaccg ctgaaatctg gtgttctcgg tgtttctgtg actggtggca
    14581 atatcgcgct ccgggctgga aaacaaccca tcaaaaacgt tattgccaga cattgcgaac
    14641 tcaccaggtt tgattattgg tactgttttt ttataagtgc cgtgaaataa tttcataata
    14701 acgacactgt atttatttta tgtaatcatt gctaatgaaa taacttgatt aagttccctt
    14761 tatccagcct gatagtggat aaagggaact caataataat tgaattaatt tattagcttc
    14821 atcgcatttt ttttggtctc ttcatcactt ttttgctctt gttgtgaaga ggattgagtg
    14881 actattgaag aattaaaatc ggccatctct tttggaaata gcgatctcaa tatattcacg
    14941 atatctgaaa atgtggtttc tttcgtcagc agttcacata aaaggaaagg ggccctggga
    15001 tcttgtctgt ataaggccag acctgccgtc agtgcggccc ggttaaggcg gctgcgttcc
    15061 ccttgcggga tactgtccag tgtatcacaa acaattttat ctgtttgatt tacatctgga
    15121 tttagtttga aggcaatggt tctgcgcttg tccattatta attacctatg agatacatac
    15181 cgttaactaa atcatattga gagttattgg ttttgaaaaa acgttcatca cgaatctgtg
    15241 tgtgtttttt tactgcatcg catattaatt ctgcgccacc gcctataacc ataacatgcg
    15301 tataaccaga aaattcattg agcgtattta atacacgttg ctcaagttta cgaagtgctt
    15361 cattcattgc ttcggtgact attgatattt tgttctcatc attaattcgt tgcttcagat
    15421 agttgttgtc ttttctgtga ataattatat cgtcagcaag atagctactt ccttttgttc
    15481 tcgcaagaga aagtgcatct tttactgcag atgtgaccag agatacacca agagatgagt
    15541 ctccgtatat tttactgatc cctgataatt tccccattac ctgagaaata tctaatgtgg
    15601 tgcccccgag gtctataatt aataaagaat ctaactcatc cagttcttgt agagcttcat
    15661 aacctgctgg tatagattca ggcatgactt ttacatcttt tattgtgaat gtatccccac
    15721 catttaatat aatttttttc cggaagtttg ctttcttacg ctcaatattt tccgtattgg
    15781 gttggttatt cctgtcgtaa tactctgtca gaggaagtgt gcaaacaata tccacttcgc
    15841 ttaccggcag accactggtc agtaaggcgt gatgcaccgc aacgacatta acgtcgctgt
    15901 attgccatgc gatattggtt gtgactacag catccgggct gattggatca aatgaatact
    15961 gttcgccgtt cagtgtgtag ttaaagacct ttttatcacc aaaagagact gcccactcgc
    16021 gtttgaaact gttcgggcta atgtgctgtt taattgttcc gtcgctttcc tgccactgta
    16081 gtttgatgtt tgttgaaccg tcatcaatga ataccaacat ttataaaact ccttatggtg
    16141 tttttttggt gtgtatttgg gtatgttttg ggtttcaagt gggtttattt gtcaagttta
    16201 ccccatttta accatcaatc aatgattatt tgtcttgttt tggtgtttta ttgggttggg
    16261 tgtgggttgt ttttgggttt tgtttggcgg gtgacaaaag atgtcgccgg g
//
