LOCUS       CP088721               17698 bp    DNA     circular BCT 09-DEC-2021
DEFINITION  Escherichia coli strain B16EC1174 plasmid pB16EC1174-5, complete
            sequence.
ACCESSION   CP088721
VERSION     CP088721.1
DBLINK      BioProject: PRJNA782071
            BioSample: SAMN23391582
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 17698)
  AUTHORS   Yoon,E.-J., Choi,Y.J., Kim,D., Won,D., Choi,J.R. and Jeong,S.H.
  TITLE     Chromosomal integration and amplification of group 9 blaCTX-M genes
            in Escherichia coli expand the spectrum of resistance under
            antimicrobial pressure
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 17698)
  AUTHORS   Yoon,E.-J., Choi,Y.J., Kim,D., Won,D., Choi,J.R. and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-NOV-2021) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, Gangnam Severance Hospital,
            Yonsei, Seoul 06273, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: other: SMRTLink v. v9.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 243x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 12/02/2021 13:42:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 5.3
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 4,687
            CDSs (total)                      :: 4,576
            Genes (coding)                    :: 4,360
            CDSs (with protein)               :: 4,360
            Genes (RNA)                       :: 111
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 84
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 216
            CDSs (without protein)            :: 216
            Pseudo Genes (ambiguous residues) :: 0 of 216
            Pseudo Genes (frameshifted)       :: 86 of 216
            Pseudo Genes (incomplete)         :: 160 of 216
            Pseudo Genes (internal stop)      :: 36 of 216
            Pseudo Genes (multiple problems)  :: 55 of 216
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..17698
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="B16EC1174"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:562"
                     /plasmid="pB16EC1174-5"
                     /geo_loc_name="South Korea"
                     /lat_lon="37.68 N 126.77 E"
                     /collection_date="2016"
                     /collected_by="Kor-GLASS"
     gene            complement(join(15553..17698,1..9))
                     /gene="traG"
                     /locus_tag="LQR06_23375"
                     /pseudo=""
     CDS             complement(join(15553..17698,1..9))
                     /gene="traG"
                     /locus_tag="LQR06_23375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_490585.1"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer mating pair stabilization
                     protein TraG"
                     /name="traG"
     gene            join(17692..17698,1..514)
                     /locus_tag="LQR06_23380"
                     /pseudo=""
     CDS             join(17692..17698,1..514)
                     /locus_tag="LQR06_23380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_709926.3"
                     /note="frameshifted; internal stop; incomplete; partial on
                     complete genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="sialate O-acetylesterase"
                     /name="sialate O-acetylesterase"
     gene            complement(1148..2755)
                     /locus_tag="LQR06_23385"
                     /pseudo=""
     CDS             complement(1148..2755)
                     /locus_tag="LQR06_23385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000080164.1"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family transposase"
                     /name="IS66 family transposase"
     gene            complement(2786..3136)
                     /gene="tnpB"
                     /locus_tag="LQR06_23390"
     CDS             complement(2786..3136)
                     /gene="tnpB"
                     /locus_tag="LQR06_23390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_311895.1"
                     /note="TnpB, as the term is used for proteins encoded by
                     IS66 family insertion elements, is considered an accessory
                     protein, since TnpC, encoded by a neighboring gene, is a
                     DDE family transposase; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="UGI44758.1"
                     /translation="MISLPSGTRIWLVAGVTDMRKSFNGLGEQVQHVLNDNPFSGHLFI
                     FRGRRGDTVKILWADADGLCLFTKRLEEGQFIWPAVRDGKVSITRSQLAMLLDKLDWRQ
                     PKTSSRNSLTML"
                     /name="tnpB"
     gene            complement(3133..3558)
                     /locus_tag="LQR06_23395"
     CDS             complement(3133..3558)
                     /locus_tag="LQR06_23395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001373091.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence hypothetical
                     protein"
                     /protein_id="UGI44759.1"
                     /translation="MELQDWRKEPRKNYSNEFKLRMVELASQPGACVAQIARENGVNDN
                     VIFKWLRLWQNEGRVSRRLPVTTSSDTGVELLPVEITPDEQKEPVAAIAPSLSTSTQTR
                     VSASSCKVEFRHGNMTLENPSPELLTVLIRELTGRGR"
                     /name="IS66 family insertion sequence hypothetical protein"
     gene            complement(4112..4324)
                     /locus_tag="LQR06_23400"
     CDS             complement(4112..4324)
                     /locus_tag="LQR06_23400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_958725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UGI44760.1"
                     /translation="MNGFRNSSRNGQVWCWQRAGSRAVILEVSGRRMEAAEAWRRAAGV
                     APRTDWQQFARKRAAHCHRRCRGRG"
                     /name="hypothetical protein"
     gene            complement(4455..5015)
                     /locus_tag="LQR06_23405"
     CDS             complement(4455..5015)
                     /locus_tag="LQR06_23405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fertility inhibition protein FinO"
                     /protein_id="UGI44761.1"
                     /translation="MTEQKRPVLTLKRKTEGETPVRSRKTIINVTTPPKWKVKKQKLAE
                     KAAREAELAAKKAQARQALSIYLNLPTLDEAVNTLKPWWPGLFDGDTPRLLACGIRDVL
                     LEDVAQRNIPLSHKKLRRALKAITRSESYLCAMKAGACRYDTEGYVTEHISQEEEAYAA
                     ARLDKIRRQNRIKAELQAVLDEK"
                     /name="fertility inhibition protein FinO"
     gene            complement(5070..5816)
                     /gene="traX"
                     /locus_tag="LQR06_23410"
     CDS             complement(5070..5816)
                     /gene="traX"
                     /locus_tag="LQR06_23410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_052669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer pilus acetylase TraX"
                     /protein_id="UGI44762.1"
                     /translation="MTTDNTNTTRNDSLAARTDTWLQSFLVWSPGQRDIIKTVALVLMV
                     LDHINLIFQLKQEWMFLAGRGAFPLFALVWGLNLSRHAHIRQPAINRLWGWGIIAQFAY
                     YLAGFPWYEGNILFAFAVAAQVLTWCETRSGWRTAAAILLMALWGPLSGTSYGIAGLLM
                     LAVSHRLYRAEDRAERLALVACLLAVIPALNLATSDAAAVAGLVMTVLTVGLVSCAGKS
                     LPRFWPGDFFPVFYACHLAVLGVLAL"
                     /name="traX"
     gene            complement(5836..11106)
                     /gene="traI"
                     /locus_tag="LQR06_23415"
     CDS             complement(5836..11106)
                     /gene="traI"
                     /locus_tag="LQR06_23415"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001463032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugative transfer relaxase/helicase TraI"
                     /protein_id="UGI44763.1"
                     /translation="MLSFSVVKSAGSAGNYYTDKDNYYVLGSMGERWAGQGAEQLGLQG
                     SVDKDVFTRLLEGRLPDGADLSRMQDGSNKHRPGYDLTFSAPKSVSMMAMLGGDKRLID
                     AHNQAVDFAVRQVEALASTRVMTDGQSETVLTGNLVMALFNHDTSRDQDPQLHTHVVVA
                     NVTQHNGEWKTLSSDKVGKTGFSENVLANRIAFGKIYQSELRQRVEALGYETEVVGKHG
                     MWEMPGVPVEAFSGRSQAIREAVGEDASLKSRDVAALDTRKSKQHVDPEVRMAEWMQTL
                     KETGFDIRAYRDAADQRAEIRTQAPGPASQDGPDVQQAVTQAIAGLSERKVQFTYTDVL
                     ARTVGILPPENGVIERARAGIDEAISREQLIPLDREKGLFTSGIHVLDELSVRALSRDI
                     MKQNRVTVHPEKSVPRTAGYSDAVSVLAQDRPSLAIVSGQGGAAGQRERVAELVMMARE
                     QGREVQIIAADRRSQMNLKQDERLSGELITGRRQLLEGMAFPPGSTVIVDQGEKLSLKE
                     TLTLLDGAARHNVQVLITDSGQRTGTGSALMAMKDAGVNTYRWQGGEQRPATIISEPDR
                     NVRYARLAGDFAASVKAGEESVAQVSGVREQAILTEAIRSELKTQGVLGHPEVTMTALS
                     PVWLDSRSRYLRDMYRPGMVMEQWNPETRSHDRYVIDRVTAQSHSLTLRDAQGETQVVR
                     ISSLDSSWSLFRPEKMPVADGERLRVTGKIPGLRVSGGDRLQVASVSEDAMTVVVPGRA
                     EPATLPVADSPFTALKLENGWVETPGHSVSDSATVFASVTQMAMDNATLNGLARSGRDV
                     RLYSSLDEPRTAEKLARHPSFTVVSDQIKARAGETLLETAISLQKAGLHTPAQQAIHLA
                     LPVLESKNLAFSMVDLLTEAKSFAAEGTGFTELGGEINAQIKRGDLLYVDVAKGYGTGL
                     LVSRASYEAEKSILRHILEGKEAVTPLMERVPGELMETLTSGQRAATRMILETSDRFTV
                     VQGYAGVGKTTQFRAVMSAVNMLPASERPRVVGLGPTHRAVGEMRSAGVDAQTLASFLH
                     DTQLQQRSGETPDFSNTLFLLDESSMVGNTDMARAYALIAAGGGRAVASGDTDQLQAIA
                     PGQPFRLQQTRSAADVVIMKEIVRQTPELREAVYSLINRDVERALSGLESVKPSQVPRQ
                     EGAWAPEHSVTEFSHSQEAKLAEAQQKAMLKGEAFPDIPMTLYEAIVRDYTGRTPEARE
                     QTLIVTHLNEDRRVLNSMIHDAREKAGELGKEQVMVPVLNTANIRDGELRRLSTWENNP
                     DALALVDSVYHRIAGISKDDGLITLEDAEGNTRLISPREAVAEGVTLYTPDKIRVGTGD
                     RMRFTKSDRERGYVANSVWTVTAVSGDSVTLSDGQQTRVIRPGQERAEQHIDLAYAITA
                     HGAQGTSETFAIALEGTEGNRKLMAGFESAYVALSRMKQHVQVYTDNRQGWTDAINNAV
                     QKGTAHDVFEPKPDREVMNAQRLFSTARELRDVAAGRAVLRQAGLAGGDSPARFIAPGR
                     KYPQPYVALPAFDRNGRSAGIWLNPLTTDDGNGLRGFSGEGRVKGRGDAQFVALQGSRN
                     GESLLADNMQDGVRIARDNPDSGVVVRIAGEGRPWNPGAITGGRVWGDIPDSSVQPGAG
                     NGEPVTAEVLAQRQAEEAIRRETERRADEIVRKMAENKPDLPDGKTELAVRDIAGQERD
                     RTASSERETALPESVLRESQREREAVREVARENLLQERLQQMERDMVRDLQKEKTLGGD
                     "
                     /name="traI"
     gene            complement(11106..13295)
                     /gene="traD"
                     /locus_tag="LQR06_23420"
     CDS             complement(11106..13295)
                     /gene="traD"
                     /locus_tag="LQR06_23420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001577029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV conjugative transfer system coupling
                     protein TraD"
                     /protein_id="UGI44755.1"
                     /translation="MSFNAKDMTQGGQIASMRIRMFSQIANIMLYCLFIFFWILVGLIL
                     WVKISWQTFVNGCIYWWCTTLEGMRDLIKSQPVYEIQYYGKTFRMNAAQVLHDKYMIWC
                     GEQLWSAFVLASVVALVICLITFFVVSWILGRQGKQQSENEVTGGRQLTDNPKDVARML
                     KKDGKDSDIRIGDLPIIRDSEIQNFCLHGTVGAGKSEVIRRLANYARQRGDMVVIYDRS
                     GEFVKSYYDPSIDKILNPLDARCAAWDLWKECLTQPDFDNTANTLIPMGTKEDPFWQGS
                     GRTIFAEAAYLMRNDPNRSYSKLVDTLLSIKIEKLRTFLRNSPAANLVEEKIEKTAISI
                     RAVLTNYVKAIRYLQGIEHNGEPFTIRDWMRGVREDQKNGWLFISSNADTHASLKPVIS
                     MWLSIAIRGLLAMGENRNRRVWFFCDELPTLHKLPDLVEILPEARKFGGCYVFGIQSYA
                     QLEDIYGEKAAATLFDVMNTRAFFRSPSHKIAEFAAGEIGEKEHLKASEQYSYGADPVR
                     DGVSTGKDMERQTLVSYSDIQSLPDLTCYVTLPGPYPAVKLSLKYQARPKVAPEFIPRD
                     INPEMENRLSAVLAAREAEGRQMASLFEPEVASGEGVTQAEQPQQPQQPQQPQQPQQPQ
                     QPVSSVINDKKSDAGVSVPAGGIEQELKMKPEEEMEQQLPPGISESGEVVDMAAYEAWQ
                     QENHPDIQQQMQRREEVNINVHRERGEDVEPGDDF"
                     /name="traD"
     gene            complement(13292..14071)
                     /locus_tag="LQR06_23425"
     CDS             complement(13292..14071)
                     /locus_tag="LQR06_23425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UGI44756.1"
                     /translation="MTSDNIAEYVGENNQFTEKPVTEYPPVIQDNTVTTKDYLYSNNID
                     TDLLVVIGGLIVILFLMMLIMYFINSLRHKKLTEILGKISFPEKSGSNLLKPEAVSCNL
                     LSLCVLAPVLCTPRKLAEVSREIIVASAQEIAWTPGSSRIDGHQGENITWSLSSQSPAD
                     KYDLINKTSRVSPDSGRFYEPDTVLDHRERVRLFIQIQFPHGSDWSEVLRLTDIVTEKV
                     SSGRAAGGYHHRHTGYTWSVSHIILFCPVPDFPGVSS"
                     /name="hypothetical protein"
     gene            complement(14274..14984)
                     /locus_tag="LQR06_23430"
     CDS             complement(14274..14984)
                     /locus_tag="LQR06_23430"
                     /inference="COORDINATES: protein motif:HMM:NF010291.0"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="complement resistance protein TraT"
                     /protein_id="UGI44764.1"
                     /translation="MVALVSSTLALSGCGAMSTAIKKRNLEVKTQMSETIWLKPDSERT
                     VFLQIKNTSDKDMSGLQGKIADAVKAKGYQVVTSPDKAYYWIQANVLKADKMDLRESQG
                     WLNRGYEGAAVGAALGAGITGYNSNSAGATLGVGLAAGLVGMAADAMVEDVNYTMITDV
                     QIAERTKATVTTDNVAALRQGTSGAKIQTSTETGNQHKYQTRVVSNANKVNLKFEEAKP
                     VLEDQLAKSIANIL"
                     /name="complement resistance protein TraT"
     gene            complement(15037..15534)
                     /locus_tag="LQR06_23435"
     CDS             complement(15037..15534)
                     /locus_tag="LQR06_23435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000605858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein"
                     /protein_id="UGI44757.1"
                     /translation="MIMRCLAHIALVTVIQFIACYLVGWGKAETVFMLFFIVLWQGLFI
                     WLFSQIRKKRNVSDEFKFSKGVWYITMPVSSLLSPLLSLMVFIIGTLYELRRVSGCISI
                     KKWGQNQLKNQYDGSEKLDFGGIEQPPTTYYNPSTGYPMHGGFDSAGNTFGTRWQDYYD
                     RQ"
                     /name="entry exclusion protein"
     Typing          complement(5840..11106)
                     /name="MOBF"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="97.21"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(11110..13295)
                     /name="MPF_Unknown"
                     /typing="mate-pair-formation"
                     /tool="MOB-suite"
                     /identity="97.425"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aggatttagt cagcagaacg cgagccgcac tggcaaaaaa tccgcataac aaatcctcgc
       61 gtatgctgga tgcaaggcga atttgactta atgaccagtg actacgcgtc acaccctcaa
      121 cactttaatc atatgttgaa gcctttcgta gggatctaaa acaatttcca ttctcagctt
      181 aataatatta ctgcgcgccg tggttttgcg gcgataccac ctggtactgg aaagaaaatt
      241 tccctcatgc gtatgaagct atttatggca attatcaaaa taatgtttta gccaatttat
      301 tttcgtcgac tccagcaaca aggtaaagag gactgacgaa cgcgctgatg aagatccgga
      361 cgatttaagc acgggatatt tcggttcagc gtaccggtca gcggagaact ggacgacgtc
      421 actgcgaagc agtcatttca gcgcggcagc ccgtcggggg attatttctg acagatttgt
      481 agaagcaatt ttgcagtttt ggcgcgaaag gtgagcgggg agtttattca tgggggatgt
      541 cctgtccatt cccagagcag aacaaaaaaa caaatgagat caaggtaata tctcttcact
      601 tgcggctcga acagcaggca attgccaata taataatctg gcacaaggtg aaaaacgcgc
      661 accgcataaa ccgttgttat tgcttacaga ttagccggat gccttaatag acatccgcgc
      721 ctttcggtta tggctcggaa atctacgaac atctacacag tttactggaa cgttttgggc
      781 cacagcgttc gcagcaccgt cctgatatgc cgttctggcg attatagtcg acggattctg
      841 gcaaatagac gatgatgata tgcttaatga tgttcaaaga aattaggcca ttattatatt
      901 atgcttgcat tttctttcat tcctaaaagc accgccatta atcccaggcg cattatgcaa
      961 aggaaatgat taggtaaaca ataagattat aatcaggaaa ggcgactcgc aataaaacgg
     1021 aaagtcgcct taacatggta aaatatgccc tttactactc ctgtatcatg aacggctcat
     1081 cacatttaaa gctgacgttg atccagacta ccataatagt aagcgtcaac ggagcaccgt
     1141 attgacgctt atttattgtg agtactacgt tccatcaggc aggagttcgt caactcggtt
     1201 ggaaggccat tccggcagta cgctcaggat atggcgcaga tacgcttccg gatcgatacc
     1261 gttcagacgg caggtgccga tcagcccgta caacagtgct ccacgctcgc cgccgtgatc
     1321 gctgccaaag aacataaagt ttttctttcc gagacagact gcacgaagcg ctcttccgca
     1381 gcatattatc cgcctccgca gaccgtcatc actgtaataa cagagggcat cccactgatt
     1441 cagtacatag ctgaacgctt cgcccagtct ggattttttc gacagcgtac cattcttctc
     1501 caccatccat tcatgcagcg gacgtcagta acactttgct tcgctgctgc ctgacggcaa
     1561 gacgctctga accggtaatc cccgtatttc atcctcgatg gcgtacagtt cactgattgc
     1621 tctcagggct tcttctgccg tcgcattttg ctgctgatgt atacatcgtg gatttttcgc
     1681 cgggcatggc ccagcacgca acttctgtca gtgcaccact tcacgtctgc actgaacaac
     1741 ctgtcgtaac ctgtgaacgc atccgctgca ggataccccg gaaggggcgg aggtgttgct
     1801 ccgggtgttt cccctgccgg ttcggcgagt acgcgaacca gaccgctgga ggagatgacg
     1861 aacccacatt gcgatcatcc cggacatacg tccagatacg ccctgttttc gcctttttct
     1921 gacccggtgc cagtaccttt accggtgtgt catcagtgtg aaccttgcgg gtgttcatta
     1981 cataacggta cagggcatca ttcaccggtg tcattaactg gcagcacgcg tcaacccagt
     2041 tggagagtaa ggcccggctc agttcgacac cctggcgggc aaagatttca ctctgacgat
     2101 acagtggcag atgttcgcag tattttcccg ttaacacgcg ggcaagtaat ccggggcccg
     2161 cgataccacg ctctatcggg cgggacggcg ccggtgcttc aacaatacag tcacattttg
     2221 tacaggcttt ttttacccgt tctgtgcgga tcactttcag ggcactgctc accagttcca
     2281 gctgttcagc gctgacttcc cccagataat ccagctcacc gccacactcc gggcaacagc
     2341 tttcttctgg ctccaggcgg tgtatttcac ggggaaggtg tgccggtaac ggacgacgat
     2401 ggcgcgactg tcgcaactgg cggggaacct gaggatcgtc ttcccgccca ctgtaacgat
     2461 cgctgtcctg ttcacgttgt ttcagcagag cctcagccag ttcaacttca cgacgcagtt
     2521 tttcagaacg ggtaccgaac agcatccggc gcagtttttc tatctgagcc cgcagatgtt
     2581 ctatttcccg ttcatcttct tcgatctttt cttcggcacg tgtcagtgca gagcgcagga
     2641 aggcttccgt ctcttcaacc agactcagtt gctggtcttt ctgacggagg gcttcagcct
     2701 gctcagagag caacctttcc agctctgcga tgcgaatgag gtatttctga ctcatgaccg
     2761 tttttataat gcggtcagga gttttttaca acattgtcag tgagttacgg ctggatgttt
     2821 ttggctgacg ccagtccagc ttatcgagga gcattgccag ttgcgagcgg gtaatggata
     2881 ccttgccgtc acgtaccgca ggccagataa actggccttc ctccaggcgt ttggtgaaca
     2941 ggcacagacc atcagcatca gcccaaagaa ttttgacggt gtcaccccgt cggccacgga
     3001 agataaacag gtgaccggag aagggattat cattcagcac atgttgtacc tgttctccca
     3061 gtccgttgaa ggatttacgc atatcggtaa cgccggcaac gagccagata cgggtacctg
     3121 atgggagtga gatcatcttc ccctcccggt cagttcacgg atcaacactg tgagcagctc
     3181 tggcgatgga ttttccagcg tcatgttacc gtgacggaat tccaccttgc aggaactggc
     3241 actgactctg gtctgagtgg aagtggataa agacggcgca atggccgcca caggttcttt
     3301 ctgctcatcc ggcgttattt ctacaggtaa taattcaacg ccagtgtcag aagaggtcgt
     3361 taccggaaga cgccgcgaaa cacgcccttc gttctgccag agcctgagcc atttgaaaat
     3421 aacattatca ttgacgccat tttcacgtgc aatctgtgca acacaagctc caggttgtga
     3481 tgccagttcc accatacgaa gtttgaattc attcgaatag tttttacgag gttcttttcg
     3541 ccagtcctgt aattccatac ttagatgtcc gtctatatca gatgggcgtc taagttacca
     3601 attctcgtct gatggctaca tacggcggtc agtttacgct taccatgcta tagcgcgaag
     3661 ccgaaaatta ttgttcgtat gctcccgctg gtccagaatg ggaatttcct ctggctgatg
     3721 ttgaactgtc atggagaatt gaaacttgtt taagactttg gcagcctact gtttttaata
     3781 cacccaataa ggtatgaaga tgaaactagg gaagttaata ccgccatgaa aagataaata
     3841 atacccgtgg aatatatttc ctcatgttac tctccatatc aaataaatgg cacctgtatt
     3901 tcagacatcc tgaatattac agcacacatt gaacaacacc ttattttgtg aaattaatca
     3961 caaaatataa aatctcgact taatacggaa aaaaatctgt gctactcaga actgtccggt
     4021 catacttccc gaccggatat taaaaaaagc aaatctcata aacttctttc agccttctga
     4081 ctcctggagt aatgaaggct gctttttttc gttaccccct tccccggcaa cgccggtggc
     4141 agtgtgcagc cctttttcgg gcaaactgct gccagtctgt ccggggcgca acaccggcag
     4201 cccgtcgcca tgcttctgcc gcttccatcc tgcgtccact gacctccaga ataacggccc
     4261 ggcttccggc acgctgccag caccagacct gaccgttccg tgaactgttt ctgaatccat
     4321 tcatatttct gtcccccttt agttgtcagt attattgtga taaatagctc agtggaatgg
     4381 ctttctttcg ggtacggaag ttatttcctt ttaagcctta tttccctgcc tcccctccct
     4441 gagggaggct ttttttattt ctcatcaagc acggcctgaa gttctgcctt tatccggttc
     4501 tggcggcgga ttttatccag acgcgctgcc gcatacgctt cctcctcctg agaaatatgc
     4561 tccgtcacat acccttccgt atcataccgg caggcaccgg ctttcatggc acacagatag
     4621 ctttctgaac gggtgatggc cttcagcgcc ctgcgcagtt ttttatgcga gagcgggata
     4681 ttccgctgcg ccacgtcttc cagtaacacg tcccggatac cgcaggccag aagccggggc
     4741 gtgtcaccgt caaataatcc cggccaccag ggcttcaggg tgttcacagc ctcatccagt
     4801 gtgggcaggt tcagataaat ggacagcgcc tgtctggcct gcgctttttt tgccgccagc
     4861 tctgcttccc gggctgcttt ctcggccagc ttctgctttt tcaccttcca ctttggtggc
     4921 gtggtgacat tgatgatggt tttccggctg cggacaggcg tctccccttc cgttttccgc
     4981 ttcagtgtca gtaccggtcg cttctgctct gtcatgctgt gttctgcctc tgacgaatca
     5041 tcctcttgcg gccaaagata ccacacccgt cacagcgcca gaacgcccag cacagccaga
     5101 tgacaggcgt agaataccgg gaaaaaatcc ccgggccaga aacggggtaa tgattttcct
     5161 gcacacgaca ccagaccaac ggtcagcacc gtcatcacaa gaccggccac cgccgctgca
     5221 tcactggtgg caaggttaag cgccggaata acagccagca ggcaggcgac cagcgccaga
     5281 cgttccgctc tgtcttccgc ccggtacagc cggtggctga ctgccagcat cagcagcccg
     5341 gcaatgccgt aactggtgcc ggacaaaggc ccccacaggg ccatcagaag aatggccgct
     5401 gctgtacgcc acccactgcg cgtttcacac cacgtcagca cctgtgccgc cactgcaaag
     5461 gcaaacagga tattcccctc ataccaggga aagccggcca gataatatgc gaactgggca
     5521 ataattcccc atccccacag ccggttaatg gccggttgcc ggatatgcgc atgacgggac
     5581 agattcagcc cccacaccag ggcaaacagc ggaaaggctc ctcgcccggc cagaaacatc
     5641 cattcctgct tcagctggaa tatcagattg atgtggtcca gtaccatcag caccagtgcc
     5701 accgttttga tgatatcccg ctgtccgggt gaccagacca gaaatgactg caaccaggta
     5761 tcggtccgtg cagccagtga atcgttacgt gtcgtgttcg tgttatccgt tgtcatcagt
     5821 gtttgtcttc ctgtatcagt ctccgcccag ggttttctct ttctgcaggt cacgaaccat
     5881 atcccgctcc atctgctgca gacgctcctg cagcagattt tcccgggcaa cctcccggac
     5941 cgcttcccgt tcccgttgtg attcacgcag cacactctcc ggcagtgcgg tttcccgttc
     6001 agaactggca gtccggtcac gttcctgccc ggcaatatcc ctgacagcca gctctgtttt
     6061 gccgtccggc aggtcaggtt tgttctctgc cattttacgg acaatttcat ctgcgcgacg
     6121 ttccgtttca cggcggatgg cctcttcagc ctgccgctgt gccagcacct ctgccgtgac
     6181 cggttcgcca tttccggccc ccggctggac gctgctgtcc gggatatccc cccacacgcg
     6241 accaccggtg atggcaccgg gattccacgg acgaccttca ccggcaattc ttaccaccac
     6301 accgctgtcg ggattatcac gggcaatccg gacaccatcc tgcatattat cagccagcag
     6361 gctctctccg ttacggctgc cctgcagggc cacgaactgc gcatccccgc ggcctttcac
     6421 ccgtccttca ccgctgaatc cccgcagccc gtttccgtca tccgtggtca gtgggttcag
     6481 ccagataccg gcggacctgc cgttacggtc aaacgccggc agtgccacat acggctgcgg
     6541 atatttacgt cccggtgcaa taaaccgtgc agggctgtct cccccggcca gccccgcctg
     6601 acggagaacg gcacggcctg ccgccacgtc ccgcagttcc cgtgccgtac tgaacagccg
     6661 ctgcgcattc atgacctccc ggtccggttt cggctcaaac acatcgtggg ctgttccttt
     6721 ctgtacggca ttgttaatgg catccgtcca gccctgacgg ttatcggtgt acacctgcac
     6781 atgctgcttc atacgcgaca gggccacgta ggctgactca aagcctgcca tcagtttccg
     6841 gttaccttcc gtgccttcaa gcgcaatggc aaaggtttca cttgtcccct gcgcaccgtg
     6901 ggcggtgatg gcataggcca ggtcaatatg ttgctctgcc cgctcctgac cggggcgaat
     6961 cacccgggtc tgctgtccgt ccgacagcgt gacactgtca ccggaaaccg ctgtcaccgt
     7021 ccagacgctg ttggccacat aaccgcgctc ccggtcactc ttcgtgaagc gcatccggtc
     7081 accggttccc acccggattt tgtctggtgt gtacagtgtg acaccttcag ccaccgcctc
     7141 ccggggcgaa atcagccgcg tgttaccttc cgcatcctcc agggttatca gcccgtcatc
     7201 cttgctgata ccggcaatcc ggtgatacac actatccacc agggcaaggg catccgggtt
     7261 attctcccag gtggagagac gacgcagttc tccgtcacgt atattcgctg tgttcaggac
     7321 aggcaccatg acctgctctt tgcccagctc accggccttt tcccgtgcat catgaatcat
     7381 gctgttcagt acgcgccggt cctcattcag gtgcgtgaca atcagcgtct gctcccgtgc
     7441 ttccggtgtc ctgccggtat agtcgcggac aatggcctca tacagtgtca tggggatatc
     7501 cgggaaagcc tcgcctttca gcatcgcctt ctgctgcgct tctgccagtt tcgcttcctg
     7561 gctgtgactg aactccgtca cggagtgctc cggtgcccat gcgccctcct gacggggaac
     7621 ctgagacggt ttcacactct caagcccgga cagtgccctt tccacatccc ggttaatcag
     7681 gctgtatacc gcctcccgca gttccggcgt ctgacgcaca atctccttca tgatgaccac
     7741 atcggcagca ctgcgcgtct gctgcagacg gaaaggctga ccgggcgcga tggcctgcag
     7801 ctggtccgtg tcaccactgg ccacggcacg accgccaccg gccgcaatca gggcgtatgc
     7861 ccgtgccata tcggtattgc ccaccattga gctctcatcg agcaggaaca gcgtgttgct
     7921 gaaatccggc gtttctccgc tgcgctgctg cagctgcgtg tcatgcagaa aggacgccag
     7981 cgtctgtgca tccacgccgg cgctgcgcat ctcaccgacc gcacggtgcg tgggccccag
     8041 ccccacaact cggggacgct cactcgccgg cagcatgttc acggctgaca tcaccgcccg
     8101 gaactgtgtg gtcttaccca caccggcata accctgtacc accgtgaaac ggtcggacgt
     8161 ttccagtatc atacgggtgg cggcacgctg tcccgacgtt aacgtctcca tgagttcgcc
     8221 gggtactctc tccatcaacg gcgtgaccgc ctccttacct tcgagaatat ggcgaagaat
     8281 acttttttct gcctcatacg acgcacggga aaccagcaga cctgtgccat agccttttgc
     8341 cacatccaca tacagtaagt caccgcgttt tatctgcgca ttgatttccc ctcccagttc
     8401 agtaaaaccg gttccttctg cagcaaacga cttcgcctct gtcagcaggt ccaccatgct
     8461 gaaggccagg tttttacttt ccagcacagg aagggccaga tgaatggcct gctgtgccgg
     8521 cgtgtgaagc ccggctttct gcagactgat agcggtttcc agcaatgtct caccggcacg
     8581 cgcctttatc tgatcagaaa ccaccgtaaa ggagggatgg cgggcaagtt tttccgcagt
     8641 acggggttca tccagcgagg aatacagccg gacatcacga ccactgcggg ccagaccgtt
     8701 cagggtcgcg ttgtccatcg ccatctgtgt gacggaggca aaaaccgtcg cactgtcgct
     8761 gacggaatgc ccgggcgttt ccacccagcc gttctccagc ttcagtgccg tgaatggtga
     8821 atcagccaca ggcagggtgg ccggttcagc ccgccccggc acaacaaccg tcatcgcatc
     8881 ttcactgacg gatgccacct gcaggcggtc accgccggag acgcggagtc cgggaatttt
     8941 ccctgtcacc ctcagtcgct cgccgtctgc caccggcatt ttttccggcc ggaacagcga
     9001 ccagctgctg tccagggagg aaatacgcac cacctgcgtt tcgccctgcg catcccgcag
     9061 ggtcaggctg tgactctgcg ctgtcacccg gtctatcaca tagcggtcat gactgcgtgt
     9121 ctccgggttc cactgctcca tcaccatccc cggtcggtac atatcccgca gataacggct
     9181 ccggctgtcc agccagaccg gtgacagtgc agtcatggtc acctcagggt gtccgagcac
     9241 gccctgcgtt ttcagctcac tgcgaatggc ctctgtcagt atggcctgtt cccgtacccc
     9301 gctgacctgt gccacgctct cttctccggc tttcacgctg gccgcaaaat ctccggccag
     9361 ccgggcatag cggacattac ggtccggttc actgatgatg gtggccggtc gctgttctcc
     9421 cccctgccag cgatatgtgt tcaccccggc atccttcatg gccatcagtg cactgcctgt
     9481 accggttcgc tgcccgctgt cggttatcag gacctgtacg ttatgacgtg cggcaccatc
     9541 cagcagggtt aacgtctctt tcagggagag tttttcgccc tggtcgacga taacggtact
     9601 gcccggcggg aaggccatgc cttccagcaa ctgacgacgt ccggttatca gttcaccgga
     9661 cagccgttca tcctgcttca ggttcatctg cgagcgacgg tcagcagcga taatctgcac
     9721 ctcccgcccc tgctcccggg ccatcatgac cagttcagcc acccgctcac gctgcccggc
     9781 tgcaccgccc tgcccggaca caatggccag cgacgggcga tcctgtgcca gaacactgac
     9841 ggcatcgctg taaccggccg tccgggggac acttttctcc ggatgtacgg tcacccggtt
     9901 ctgtttcatg atgtcacgac tgagtgcccg gactgacagc tcatcgagca catgaatccc
     9961 ggacgtgaac agccccttct cacgatcgag ggggataagc tgctcacggc tgatggcctc
    10021 atcgataccg gcgcgtgccc gttcaatcac accattttcc ggcggcagta tgccgaccgt
    10081 cctggccagc acgtccgtat acgtgaactg cacttttcgt tcacttaatc cggcaatggc
    10141 ctgtgtcacc gcctgctgca catccggccc gtcctgtgaa gcaggcccgg gcgcctgcgt
    10201 gcggatctcc gcacgctgat ccgccgcgtc acgatatgcc cggatgtcga acccggtttc
    10261 cttcagcgtc tgcatccatt cagccattct gacttcagga tcgacgtgct gtttggattt
    10321 acgcgtatcc agtgccgcca catcccggga tttcagcgag gcgtcttcac cgacggcctc
    10381 ccggatagcc tgtgagcgtc cggagaaggc ttccaccggt acgcccggca tctcccacat
    10441 accgtgctta ccgaccactt cggtttcata acccagcgcc tcaacgcgct gacgtaactc
    10501 actctgatat attttcccga acgcaatccg gttcgcgagc acgttctcgg aaaatccggt
    10561 tttccccact ttgtcactgc tcagtgtctt ccattcgccg ttatgctgcg tgacattagc
    10621 caccaccaca tgcgtgtgta actgtgggtc ctgatcgcga ctggtgtcat ggttaaacag
    10681 tgccatcacc agattaccgg tcagcaccgt ttctgactgt ccgtccgtca tcacccgtgt
    10741 ggaagccagc gcctccacct gacggacagc aaaatccaca gcctggttat gtgcatcaat
    10801 aagacgttta tcccccccga gcatggccat catggagaca cttttggggg cggagaaggt
    10861 caggtcgtag ccgggacgat gcttattact gccatcctgc atgcggctta aatccgcccc
    10921 gtccggcagc ctgccctcca gaagacgggt aaaaacatcc ttatcgacgc tgccctgcag
    10981 cccaagctgt tcagccccct gaccggccca gcgttctccc atgctgccca gcacatagta
    11041 attatccttg tcggtgtaat agtttccggc actgcctgcc gatttaacaa cgctgaaact
    11101 caacatcaga aatcatctcc cggctcaaca tcctccccgc gctcccggtg cacattaatg
    11161 ttcacctctt cacgacgctg catctgctgc tggatgtccg gatgattttc ctgttgccat
    11221 gcctcataag cggccatatc caccacttca ccggattcac tgatcccggg tggcagttgc
    11281 tgttccatct cttcttccgg tttcattttc agctcctgct cgatcccccc tgccggaaca
    11341 ctcacacctg catctgactt cttatcattg atgacagaag acactggctg ttgtggctgt
    11401 tgtggctgtt gtggctgttg tggctgttgt ggctgttgtg gctgttcagc ctgagtcacg
    11461 ccttctccgg aggcaacctc cggttcgaag aggctggcca tctggcgacc ttctgcttcc
    11521 cttgcagcaa gtacggcact cagacggttc tccatttccg ggttgatgtc acgcggaata
    11581 aactccggag cgaccttcgg tcgtgcctga tatttcaggg agagttttac tgccggatac
    11641 ggtccgggca gagtgacata gcaggtcaga tccggcagag actgaatgtc ggaataactg
    11701 accagtgtct gacgctccat atccttaccg gtcgataccc cgtcacgtac cgggtcagca
    11761 ccgtaggaat actgctcgct ggctttcagg tgctctttct caccaatctc accggcagcg
    11821 aactctgcaa tcttatggct cggggaacgg aaaaaagcac gggtgttcat gacgtcaaac
    11881 agcgtggccg ccgctttctc accgtagata tcttccagct gggcatagga ctggatacca
    11941 aacacataac agccaccgaa cttacgggct tccggcagga tctccaccag gtccggcagt
    12001 ttgtgtaacg tgggtaactc atcacagaaa aaccacacac gacggttacg gttttctccc
    12061 attgccagca gaccacgaat ggcaatggac agccacatgg agatcacagg cttcagggag
    12121 gcatgggtgt cggcgttcga cgaaataaac agccagccgt ttttctgatc ttcccggaca
    12181 ccacgcatcc agtcacggat ggtgaagggc tcaccgttat gctcaatccc ctgcaggtaa
    12241 cggatggctt tcacgtagtt ggtcagcaca gcacggatgg aaatcgccgt tttctcaatt
    12301 ttctcttcca ccaggttggc cgccggtgaa ttacgcagga aggtacgcag tttttcaatt
    12361 ttgatggaaa gcagtgtgtc caccagtttg ctgtagctgc ggttggggtc attacgcatc
    12421 aggtacgccg cttccgcaaa aatggtacgt cctgaaccct gccagaacgg gtcctctttt
    12481 gtacccatag ggatcagagt atttgcggta ttatcaaaat ccggctgtgt caggcactcc
    12541 ttccacaaat cccatgcggc acagcgggca tccagcggat tcaggatttt atcgatggag
    12601 ggatcatagt aacttttaac aaattcccct gaacggtcat aaatcaccac catatcaccg
    12661 cgctgacggg catagttggc cagacgacgg ataacctccg acttaccggc cccgaccgtg
    12721 ccgtgcagac agaagttctg gatttcggaa tcccggataa tcggcaggtc gccaatccgg
    12781 atatcggagt ccttgccgtc ttttttcagc atccgggcaa cgtctttcgg attgtctgtc
    12841 agctgacgac cacctgtgac ttcattttcg ctctgttgtt taccctgacg ccccagaatc
    12901 caggagacaa caaagaaggt gatcaggcaa ataaccaggg ccacgacaga cgccagaacg
    12961 aatgcggacc atagctgctc accgcaccag atcatatatt tatcatgcag tacctgggca
    13021 gcgttcatcc ggaaggtttt gccgtaatac tgaatctcat atactggctg ggacttgatt
    13081 aaatcccgca tgccttccag cgtggtacac caccagtaaa tacagccgtt cacaaacgtc
    13141 tgccagctta tttttaccca taaaatcaga ccaacgagta tccagaaaaa aataaacagg
    13201 cagtaaagca tgatattggc gatctggctg aacatgcgga tacgcatgga cgcaatctga
    13261 ccgccctggg tcatatcctt tgcgttaaaa ctcatgatga aactccggga aaatctggaa
    13321 cagggcagaa aaggatgatg tgggaaacag accaggtgta ccctgtatgc cggtggtgat
    13381 acccgcctgc agccctgccg gaagagacct tctctgtaac aatgtcagtc aggcgcaata
    13441 cttcagacca gtcactcccg tgcggaaact ggatctgaat aaaaaggcgt acccgttcac
    13501 ggtgatccag aactgtgtcc ggttcataaa aacggccact gtcaggagaa acacgggacg
    13561 ttttattgat gagatcatac ttatcggcag gagactgcga tgacagagac caggtaatat
    13621 tttcgccctg atgaccatca atacgactgc tccccggcgt ccatgcaatt tcctgcgcac
    13681 tcgccacgat gatctccctg gagacttctg ccagctttct gggtgtacag agtaccggtg
    13741 ccagcacaca cagggacaac aaattacagc tgaccgcctc cggtttaagc aaattgctcc
    13801 cggatttttc aggaaaagat atttttccca gtatttcagt taatttctta tgcctgagag
    13861 aattaataaa gtacatgata agcatcatga gaaacaatat aacaataagc cctccgataa
    13921 ccactaaaag gtcagtatca atattattgc tgtacagata gtctttagtg gtcactgtat
    13981 tatcctgtat caccgggggg tattcagtta caggcttctc agtaaattga ttattctcac
    14041 caacatattc agcgatattg tctgatgtca taatgacttt ctccggaaga tcccggcttc
    14101 gccggcaaca cttcacggtc gcacaaagaa tttgcacaac cgctcagtgt tttcatattt
    14161 atttcggaaa cgccggggag aaataaaatt tattttattt ctttccgggg ttggacaacg
    14221 agcaaagcga ggcgtcagtc aggaggccgg tcagaccagc ctccggaaga taatcagaga
    14281 atatttgcga ttgatttggc cagctggtct tcgagaacag gcttcgcctc ttcaaatttc
    14341 aggttaacct tgttcgcatt tgagaccaca cgggtctggt atttatgctg gttacccgtt
    14401 tcagtactgg tctgaatttt cgcaccggat gtgccctgac gcagggcggc aacattatcc
    14461 gttgtcaccg ttgccttagt acgctctgca atctgcacat ccgtgatcat ggtatagttc
    14521 acatcttcca ccatcgcatc tgcagccata cccaccagac cagcagcaag gcccacaccg
    14581 agtgtggcac cggcagaatt tgagttatag ccggtaatac cggcacctaa cgctgcacca
    14641 acagctgcgc cttcataacc acggttcagc catccctgag actcccgcag atccatctta
    14701 tcagccttca gcacattcgc ctgaatccag tagtaggctt tatccggaga agtcaccacc
    14761 tgatatcctt ttgctttcac agcatcagca attttgccct gcagcccact catgtcttta
    14821 tcagacgtgt ttttgatctg cagaaatacc gtgcgttcgc tgtcgggttt aagccagatg
    14881 gtctcactca tctgagtctt cacctcaagg ttacgcttct tgattgctgt gctcatcgca
    14941 ccacaccctg aaagggccag agtggaactg accagtgcaa ccatcattaa tttttttgtt
    15001 ttcatcaaat tacctttttt acaaactaca gttttcttat tgcctgtcat aataatcctg
    15061 ccaacgagtc ccaaaagtat ttcccgctga gtcaaagcct ccatgcatag gatatccggt
    15121 tgaagggtta tagtaggtcg ttgggggctg ttcaatgccc ccgaagtcta acttttcact
    15181 cccatcatat tggtttttga gttgattttg accccatttt tttatgctta tgcaaccact
    15241 aactcgcctt aattcgtata gtgtaccaat gataaaaacc atcaggctta ataacggaga
    15301 gagtaaggaa gatactggca tcgttatata ccaaacgcct ttactgaatt taaactcatc
    15361 cgacacattc cgtttttttc gtatttgaga gaacaaccat ataaacagtc cctgccatag
    15421 cactatgaag aacagcataa aaactgtttc ggccttcccc caaccaacca gatagcaggc
    15481 gataaactgt atcaccgtta ccagagcaat atgggctaga catctcatta tcatctccca
    15541 aacacagcat tattacttat acttatcctg atactccttt gcccttttca tcagttcctg
    15601 tggactgtca gccccgggca ttctttcctg aaccgacttt tcttcattat atttattatt
    15661 ctgagataat gcctctgttt tatggtgatt ctgtagttca gaatactgtc ctcttacaat
    15721 attttcctcg ccacgtatgc tgttctgagt atcacctata ttccctttat attctgtgac
    15781 catattatca acctgatgtt ttacatcatt acggatatta ctgtcctgcg ttctttgctc
    15841 aataatggcc tgatgtccct gatggtcagc aataatatcc tgactgccac cacccgaagg
    15901 tacgctctcc attcctttac caatatcgcc acgggattcc cgccaggcat tatcaacacc
    15961 aggctgtatc tgttcctgca caaaagacca ggccatcgcc cgacggcgtt ctgcaatctc
    16021 cggtgaactg gtatttgtca gaatagcttc tgcatcctgt ggcgcgtgtt tcattacata
    16081 ctgtgcaaac tgttgcgaca agtcttcact catctgccca ctcatgcttt cagtacggga
    16141 tgccatttca gcatattcat ggctgcgagt catattcgtc gtgtactggt cgtaactctg
    16201 cttcgctgaa ttcagggctg cagacaactg atccacacgg gaatcagcat tattgtcagt
    16261 atggctgccg gactcactga ccttgcgact ggtaaagtaa tcgctggcct ctttaaagtc
    16321 ttgtgtagct ctggcatcga tatcatgacg agcatcattg ctggcccgtg aaccactgct
    16381 ggcctgatgc gcatcatcat cactccagtc aatgccagcc cgaccaccgc ctctaacgcc
    16441 taatcctcca ccaacaccaa gaattttagg tttaaccccc cattcagcat gagcatcgcc
    16501 atacatcccg gcagaagctc tcgtacttct ggatgccagt tcctgagtcg cctgctcatt
    16561 actgatatta tgcgccttcg catagctttc cattgcactg cgcatacggc tggccatcat
    16621 ggaatcctgt gcactcatgg tgctgtcagc gccaccggtg acagaatcac tgctcccccg
    16681 gttagaacca aactgactga gcgtgttcca ggcactggca atactgctgc tgaaaccatg
    16741 cagggcactt tctgctctgt tcgacgcctc ccgggccatt tcctgttgtg ccgctgcaat
    16801 ctgacgcgtt gcattgatac caaccggtaa ccgggacatc gctccgcttg catccatcac
    16861 catattaccg tcacgggtct gtgtggcagt tgcgccactg ccggtctggt acatcatctg
    16921 accaaacgac gtggtgctgt tggtgctcca gctgaagccg ttcacgtttt ccgtctgcat
    16981 gttgccgtag gagtaattac cgtcaaccac actgcctgct gcactggccg tcggactgat
    17041 agaggaagag gcgaagtggc tgtacacgct ggaaaaacct gcgccaaggc cttttaccat
    17101 catccatgac aacgggggga tcatggctga aagatacccg gcagtagagg ccaggtcaga
    17161 gtatttcagc tgtatctgag agagttcaga cagcacgacc ggcgcaccat tcatcttcgc
    17221 atagaatgtc atggcactgt tcagaatggc atacaacaac ggccaggtct gcagccacat
    17281 cagggcaaac acatagcctt tcaggacgga cagtgtcagt ttgttgaaga cagctgccag
    17341 taccagaagc gggaaatacc aatggcaatt cccgtcagga tagtctgtac cattggcagg
    17401 tttcgcattg tcacatgacc gatagagaca tgcgccagac gttgcttctc catcgatgac
    17461 gtggtggcca gattcaccag gctggcggtg tcaccattac gggcggcatt actgtgatac
    17521 cctctttcag gcatttattg tgacgttctg gcgcataatc tggctgagac tgactggagc
    17581 cgtagaaata actgtaactg tcactgacca gttgtctgaa taaaaggtcc gggtccggtc
    17641 tgccgccaaa tatctgctgc acataataat gccaggtctt gcctcccgtc tttgtatc
//
