LOCUS       CP088533               17677 bp    DNA     circular BCT 09-DEC-2021
DEFINITION  Escherichia coli strain E16EC0601 plasmid pE16EC0601-4, complete
            sequence.
ACCESSION   CP088533
VERSION     CP088533.1
DBLINK      BioProject: PRJNA782071
            BioSample: SAMN23391648
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 17677)
  AUTHORS   Yoon,E.-J., Choi,Y.J., Kim,D., Won,D., Choi,J.R. and Jeong,S.H.
  TITLE     Chromosomal integration and amplification of group 9 blaCTX-M genes
            in Escherichia coli expand the spectrum of resistance under
            antimicrobial pressure
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 17677)
  AUTHORS   Yoon,E.-J., Choi,Y.J., Kim,D., Won,D., Choi,J.R. and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-NOV-2021) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, Gangnam Severance Hospital,
            Yonsei, Seoul 06273, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: other: SMRTLink v. v9.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 122x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 12/02/2021 11:45:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 5.3
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,262
            CDSs (total)                      :: 5,142
            Genes (coding)                    :: 4,944
            CDSs (with protein)               :: 4,944
            Genes (RNA)                       :: 120
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 89
            ncRNAs                            :: 9
            Pseudo Genes (total)              :: 198
            CDSs (without protein)            :: 198
            Pseudo Genes (ambiguous residues) :: 0 of 198
            Pseudo Genes (frameshifted)       :: 72 of 198
            Pseudo Genes (incomplete)         :: 138 of 198
            Pseudo Genes (internal stop)      :: 32 of 198
            Pseudo Genes (multiple problems)  :: 40 of 198
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..17677
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="E16EC0601"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:562"
                     /plasmid="pE16EC0601-4"
                     /geo_loc_name="South Korea"
                     /lat_lon="34.87 N 126.99 E"
                     /collection_date="2016"
                     /collected_by="Kor-GLASS"
     gene            complement(join(17100..17677,1..436))
                     /gene="intI1"
                     /locus_tag="LQT69_26200"
     CDS             complement(join(17100..17677,1..436))
                     /gene="intI1"
                     /locus_tag="LQT69_26200"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1 integron integrase IntI1"
                     /protein_id="UGF60839.1"
                     /translation="MKTATAPLPPLRSVKVLDQLRERIRYLHYSLRTEQAYVHWVRAFI
                     RFHGVRHPATLGSSEVEAFLSWLANERKVSVSTHRQALAALLFFYGKVLCTDLPWLQEI
                     GRPRPSRRLPVVLTPDEVVRILGFLEGEHRLFAQLLYGTGMRISEGLQLRVKDLDFDHG
                     TIIVREGKGSKDRALMLPESLAPSLREQLSRARAWWLKDQAEGRSGVALPDALERKYPR
                     AGHSWPWFWVFAQHTHSTDPRSGVVRRHHMYDQTFQRAFKRAVEQAGITKPATPHTLRH
                     SFATALLRSGYDIRTVQDLLGHSDVSTTMIYTHVLKVGGAGVRSPLDALPPLTSER"
                     /name="intI1"
     gene            593..1065
                     /gene="dfrA17"
                     /locus_tag="LQT69_26205"
                     /pseudo=""
     CDS             593..1065
                     /gene="dfrA17"
                     /locus_tag="LQT69_26205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001389366.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="trimethoprim-resistant dihydrofolate reductase
                     DfrA17"
                     /name="dfrA17"
     gene            1196..1983
                     /locus_tag="LQT69_26210"
                     /pseudo=""
     CDS             1196..1983
                     /locus_tag="LQT69_26210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000503573.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="AadA family aminoglycoside
                     3''-O-nucleotidyltransferase"
                     /name="AadA family aminoglycoside
                     3''-O-nucleotidyltransferase"
     gene            2188..2534
                     /locus_tag="LQT69_26215"
                     /pseudo=""
     CDS             2188..2534
                     /locus_tag="LQT69_26215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679427.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="SMR family transporter"
                     /name="SMR family transporter"
     gene            2528..3367
                     /gene="sul1"
                     /locus_tag="LQT69_26220"
     ARG             2529..3364
                     /name="sul1"
                     /gene="sul1"
                     /gene_name="sulfonamide-resistant dihydropteroate synthase
                     Sul1"
                     /tool="amrfinderplus"
                     /drug_class="SULFONAMIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            3495..3698
                     /locus_tag="LQT69_26225"
     CDS             3495..3698
                     /locus_tag="LQT69_26225"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UGF60844.1"
                     /translation="MDSEEPPNVRVACSGDIDEVVRLMHDAAAWMSAKGTPAWDVARID
                     RTFAETFVLRSELLGIASENGK"
                     /name="hypothetical protein"
     gene            3854..5058
                     /gene="chrA"
                     /locus_tag="LQT69_26230"
                     /pseudo=""
     CDS             3854..5058
                     /gene="chrA"
                     /locus_tag="LQT69_26230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004896675.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="chromate efflux transporter"
                     /name="chrA"
     gene            5069..5374
                     /locus_tag="LQT69_26235"
     CDS             5069..5374
                     /locus_tag="LQT69_26235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000130000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="UGF60841.1"
                     /translation="MTDKDLYGGLIRLHILHHAAEEPVFGLGIIEELRRHGYEMSAGTV
                     YPMLHGLEKKGYLTSRHERTGRRERRVYDITEQGRTALADAKTKVKELFGELVEGG"
                     /name="PadR family transcriptional regulator"
     gene            5418..5483
                     /locus_tag="LQT69_26240"
                     /pseudo=""
     CDS             5418..5483
                     /locus_tag="LQT69_26240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005229646.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /name="EAL domain-containing protein"
     gene            5601..6365
                     /locus_tag="LQT69_26245"
     CDS             5601..6365
                     /locus_tag="LQT69_26245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001389365.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS6100 family transposase"
                     /protein_id="UGF60842.1"
                     /translation="MTDFKWRHFQGDVILWAVRWYCRYPISYRDLEEMLAERGISVDHT
                     TIYRWVQCYAPEMEKRLRWFWRRGFDPSWRLDETYVKVRGKWTYLYRAVDKRGDTIDFY
                     LSPTRSAKAAKRFLGKALRGLKHWEKPATLNTDKAPSYGAAITELKREGKLDRETAHRQ
                     VKYLNNVIEADHGKLKILIKPVRGFKSIPTAYATIKGFEVMRALRKGQARPWCLQPGIR
                     GEVRLVERAFGIGPSALTEAMGMLNHHFAAAA"
                     /name="IS6-like element IS6100 family transposase"
     gene            complement(6858..7442)
                     /gene="mphR(A)"
                     /locus_tag="LQT69_26250"
     CDS             complement(6858..7442)
                     /gene="mphR(A)"
                     /locus_tag="LQT69_26250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001137892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide-binding transcriptional repressor
                     MphR(A)"
                     /protein_id="UGF60843.1"
                     /translation="MPRPKLKSDDEVLEAATVVLKRCGPIEFTLSGVAKEVGLSRAALI
                     QRFTNRDTLLVRMMERGVEQVRHYLNAIPIGAGPQGLWEFLQVLVRSMNTRNDFSVNYL
                     ISWYELQVPELRTLAIQRNRAVVEGIRKRLPPGAPAAAELLLHSVIAGATMQWAVDPDG
                     ELADHVLAQIAAILCLMFPEHDDFQLLQAHA"
                     /name="mphR(A)"
     gene            complement(7442..8683)
                     /gene="mrx(A)"
                     /locus_tag="LQT69_26255"
                     /gene_synonym="mrx"
                     /pseudo=""
     CDS             complement(7442..8683)
                     /gene="mrx(A)"
                     /locus_tag="LQT69_26255"
                     /gene_synonym="mrx"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000004159.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide resistance MFS transporter Mrx(A)"
                     /name="mrx(A)"
     gene            complement(8680..9582)
                     /locus_tag="LQT69_26260"
                     /pseudo=""
     CDS             complement(8680..9582)
                     /locus_tag="LQT69_26260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219391.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Mph(A) family macrolide 2'-phosphotransferase"
                     /name="Mph(A) family macrolide 2'-phosphotransferase"
     gene            complement(9704..10409)
                     /locus_tag="LQT69_26265"
                     /pseudo=""
     CDS             complement(9704..10409)
                     /locus_tag="LQT69_26265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221000.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS26 family transposase"
                     /name="IS6-like element IS26 family transposase"
     gene            10514..10807
                     /gene="tnpB"
                     /locus_tag="LQT69_26270"
     CDS             10514..10807
                     /gene="tnpB"
                     /locus_tag="LQT69_26270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013183349.1"
                     /note="TnpB, as the term is used for proteins encoded by
                     IS66 family insertion elements, is considered an accessory
                     protein, since TnpC, encoded by a neighboring gene, is a
                     DDE family transposase; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="UGF60835.1"
                     /translation="MRNGFNGLAAKVQTTLKDDPMSGHVFIFRGRNGSQVKLLWSTGDG
                     LCLLTKRLERGRFAWPSARDGKVFLTPAQLAMLLEGIDWRQPKRLLTSLTML"
                     /name="tnpB"
     gene            10856..11799
                     /locus_tag="LQT69_26275"
                     /pseudo=""
     CDS             10856..11799
                     /locus_tag="LQT69_26275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000099160.1"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family transposase"
                     /name="IS66 family transposase"
     gene            11885..12914
                     /gene="istA"
                     /locus_tag="LQT69_26280"
                     /pseudo=""
     CDS             11885..12914
                     /gene="istA"
                     /locus_tag="LQT69_26280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000627495.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS21 family transposase"
                     /name="istA"
     gene            12911..13693
                     /gene="istB"
                     /locus_tag="LQT69_26285"
     CDS             12911..13693
                     /gene="istB"
                     /locus_tag="LQT69_26285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_858162.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS21-like element IS100kyp family helper ATPase
                     IstB"
                     /protein_id="UGF60836.1"
                     /translation="MMMELQHQRLMALAGQLQLESLISAAPALSQQAVDQEWSYMDFLE
                     HLLHEEKLARHQRKQAMYTRMAAFPAVKTFEEYDFTFATGAPQKQLQSLRSLSFIERNE
                     NIVLLGPSGVGKTHLAIAMGYEAVRAGIKVRFTTAADLLLQLSTAQRQGRYKTTLQRGV
                     MAPRLLIIDEIGYLPFSQEEAKLFFQVIAKRYEKSAMILTSNLPFGQWDQTFAGDAALT
                     SAMLDRILHHSHVVQIKGESYRLRQKRKAGVIAEANPE"
                     /name="istB"
     gene            13761..14369
                     /locus_tag="LQT69_26290"
                     /pseudo=""
     CDS             13761..14369
                     /locus_tag="LQT69_26290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000099160.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family transposase"
                     /name="IS66 family transposase"
     gene            complement(14432..15223)
                     /locus_tag="LQT69_26295"
     CDS             complement(14432..15223)
                     /locus_tag="LQT69_26295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000977390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4198 domain-containing protein"
                     /protein_id="UGF60837.1"
                     /translation="MMKNTGYILALCLTASGHVLAHDVWITGKQAENNITAEIGYGHNF
                     PSKGTIPDRRNFFENPRIYNGKETITLKPASTDYVYKTESASKDNGYVLSTYMKPGYWS
                     RTSSGWKPVSREGRNDVAYCEFVTKYAKSFIPGEQQMPAQLYQSPTGHELEIIPLSDIS
                     RFSEDVKLKVLYKTSPLAGAIMELDSVSYLKSSRHTHAVEHKHPVHKAELTFVTNEDGI
                     VTVPSLHIGQWLAKVQNKKSFQDKSLCDETVDVATLSFSRN"
                     /name="DUF4198 domain-containing protein"
     gene            complement(15230..15841)
                     /locus_tag="LQT69_26300"
                     /pseudo=""
     CDS             complement(15230..15841)
                     /locus_tag="LQT69_26300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001555799.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="TonB-dependent receptor"
                     /name="TonB-dependent receptor"
     gene            15904..16608
                     /locus_tag="LQT69_26305"
     CDS             15904..16608
                     /locus_tag="LQT69_26305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS26 family transposase"
                     /protein_id="UGF60838.1"
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIINATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="IS6-like element IS26 family transposase"
     gene            complement(16661..16897)
                     /locus_tag="LQT69_26310"
                     /pseudo=""
     CDS             complement(16661..16897)
                     /locus_tag="LQT69_26310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003132006.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3330 domain-containing protein"
                     /name="DUF3330 domain-containing protein"
     ARG             complement(8665..9299)
                     /name="mphA"
                     /gene="mphA"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="100.0"
                     /coverage="70.1"
     ARG             1201..1913
                     /name="aadA5"
                     /gene="aadA5"
                     /gene_name="ANT(3'')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="98.74"
                     /coverage="90.46"
     ARG             complement(7634..8427)
                     /name="Mrx"
                     /gene="Mrx"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="99.6"
                     /coverage="64.08"
     ARG             complement(7443..7633)
                     /name="Mrx"
                     /gene="Mrx"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="100.0"
                     /coverage="15.29"
ORIGIN
        1 gcatgcccgt tccatacaga agctgggcga acaaacgatg ctcgccttcc agaaaaccga
       61 ggatgcgaac cacttcatcc ggggtcagca ccaccggcaa gcgccgcgac ggccgaggtc
      121 ttccgatctc ctgaagccag ggcagatccg tgcacagcac cttgccgtag aagaacagca
      181 aggccgccaa tgcctgacga tgcgtggaga ccgaaacctt gcgctcgttc gccagccagg
      241 acagaaatgc ctcgacttcg ctgctgccca aggttgccgg gtgacgcaca ccgtggaaac
      301 ggatgaaggc acgaacccag tggacataag cctgttcggt tcgtaaactg taatgcaagt
      361 agcgtatgcg ctcacgcaac tggtccagaa ccttgaccga acgcagcggt ggtaacggcg
      421 cagtggcggt tttcatggct tgttatgact gtttttttgt acagtctatg cctcgggcat
      481 ccaagcagca agcgcgttac gccgtgggtc gatgtttgat gttatggagc agcaacgatg
      541 ttacgcagca gggcagtcgc cctaaaacaa agttagccat taagggagtt aattgaaaat
      601 atcattgatt tctgcagtgt cagaaaatgg cgtaatcggt agtggtcctg atatcccgtg
      661 gtcagtaaaa ggtgagcaac tactctttaa agcgctcaca tataatcaat ggctccttgt
      721 cggaagaaaa acatttgact ctatgggtgt tcttccaaat cgcaaatatg cagtagtgtc
      781 aagaacggaa tttcaagctc aaatgaaaac gtcctagttt ttccttcaat agaaaatgct
      841 ttgaaagagc tatcaaaagt tacagatcat gtatatgtct ctggcggggg tcaaatctat
      901 aatagcctta ttgaaaaagc agatataatt catttgtcta ctgttcacgt tgaagtcgaa
      961 ggtgatatca aattccctat aatgcctgag aatttcaatt tggtttttga acagtttttt
     1021 atgtctaata taaattatac ataccagatt tggaaaaaag gctaacaatg cgttgcagca
     1081 ccagtcgctt cgctccttgg acagctttta agtcgcgtct ttgtggtttt gctgcgcaaa
     1141 agtattccac aaagccgcaa cttaaaagct gccgctgaac ttaacgttag gcatcatggg
     1201 tgaatttttc cctgcacaag tttttcaagc agctgtccca cgctcgcgcg gtgatcgagc
     1261 gccatctggc tgcgacactg gacacaatcc acctgttcgg atctgcgatc gatggagggc
     1321 tgaagccgga cagcgacata gacttgctcg tgaccgtcag cgccgcacct aacgattcgc
     1381 tccggcaggc gctaatgctc gatttgctga aagtctcatc accgccaggc gatggcggaa
     1441 catggcgacc gctggagcta actgttgtcg ctcgaagcga agtagtgcct tggcgctatc
     1501 cggcgcggcg tgagcttcag ttcggtgagt ggctccgcca cgacatcctt tccggaacgt
     1561 tcgagcctgc cgttctggat cacgatcttg cgattttgct gaccaaggcg aggcaacaca
     1621 gccttgcgct tctaggccca tccgcagcca cgtttttcga gccggtgccg aaggagcatt
     1681 tctccaaggc gctttcgaca ctattgccca gtggaatgca gagtcggatt ggaagggtga
     1741 cgagcggaac gtcgttcttg ctcttgctcg catttggtac agcgcttcaa ctggtctcat
     1801 tgctcctaag gacgttgctg ccgcatgggt atcggagcgt ttgcctgccg agcatcggcc
     1861 cctcatctgc aaggcacgcg cggcgtacct gggtagcgag gacgacgacc tagcaatgcg
     1921 cgtcgaagag acggcgcgtt cgttcgatat gccaaagcaa cgattgagag aatcttgcgt
     1981 tgagcggcat gtgcgaaaag tgcatcgacc cgcccgaggg catctgatgc ctaactcggc
     2041 gttcaagcgg acgggctgcg cccgccgctc aactatgcgt tagatgcact aagcacataa
     2101 ttgctcacag ccaaactatc aggtcaagtc tgcttttatt atttttaagc gtgcataata
     2161 agccctacac aaattgggag atatatcatg aaaggctggc tttttcttgt tatcgcaata
     2221 gttggcgaag taatcgcaac atccgcatta aaatctagcg agggctttac taagcttgcc
     2281 ccttccgccg ttgtcataat cggttatggc atcgcatttt tattttcttt ctctggttct
     2341 gaaatccatc ctgtcggtgt tgcttatgca gtctggtcgg gactcggcgt cgtcataatt
     2401 acagccattg cctggttgct tcatggcaaa agcttgatgc gtggggcttt gtaggtatgg
     2461 ggctcataat tgctgccttt ttgctcgccc gatccccatc gtggaagtcg ctgcggaggc
     2521 cgacgccatg gtgacggtgt tcggcattct gaatctcacc gaggactcct tcttcgatga
     2581 gagccggcgg ctagaccccg ccggcgctgt caccgcggcg atcgaaatgc tgcgagtcgg
     2641 atcagacgtc gtggatgtcg gaccggccgc cagccatccg gacgcgaggc ctgtatcgcc
     2701 ggccgatgag atcagacgta ttgcgccgct cttagacgcc ctgtccgatc agatgcaccg
     2761 tgtttcaatc gacagcttcc aaccggaaac ccagcgctat gcgctcaagc gcggcgtggg
     2821 ctacctgaac gatatccaag gatttcctga ccctgcgctc tatcccgata ttgctgaggc
     2881 ggactgcagg ctggtggtta tgcactcagc gcagcgggat ggcatcgcca cccgcaccgg
     2941 tcaccttcga cccgaagacg cgctcgacga gattgtgcgg ttcttcgagg cgcgggtttc
     3001 cgccttgcga cggagcgggg tcgctgccga ccggctcatc ctcgatccgg ggatgggatt
     3061 tttcttgagc cccgcaccgg aaacatcgct gcacgtgctg tcgaaccttc aaaagctgaa
     3121 gtcggcgttg gggcttccgc tattggtctc ggtgtcgcgg aaatccttct tgggcgccac
     3181 cgttggcctt cctgtaaagg atctgggtcc agcgagcctt gcggcggaac ttcacgcgat
     3241 cggcaatggc gctgactacg tccgcaccca cgcgcctgga gatctgcgaa gcgcaatcac
     3301 cttctcggaa accctcgcga aatttcgcag tcgcgacgcc agagaccgag ggttagatca
     3361 tgcctagcat tcaccttccg gccgcccgct agcggaccct ggtcaggttc cgcgaaggtg
     3421 ggcgcagaca tgctgggctc gtcaggatca aactgcacta tgaggcggcg gttcataccg
     3481 cgccagggga gcgaatggac agcgaggagc ctccgaacgt tcgggtcgcc tgctcgggtg
     3541 atatcgacga ggttgtgcgg ctgatgcacg acgctgcggc gtggatgtcc gccaagggaa
     3601 cgcccgcctg ggacgtcgcg cggatcgacc ggacattcgc ggagaccttc gtcctgagat
     3661 ccgagctcct agggatcgcc tcagaaaacg gaaaataaag cacgctaagc cgtaagtaag
     3721 cgtgctcctg tgaaagccac agctaaaact gcgtagtaca catagaggta tttttttcta
     3781 gatttatatc gaatttcgtt atcgaatttc gcttattatt gatcaactcg ttgcagatca
     3841 tgaaggcgaa agtatgacga ataaccctac cgatgacagc agaccatggt cggtctttct
     3901 tatttttctg cggcttggat tgacatcttt tggcggcccc attgcgcact tgggctactt
     3961 ccgcgccgaa tttgtcacac ggcggcgctg gctctccgaa cggagctatg ctgacttggt
     4021 cgcgctttgt cagttcttgc cagggcctgc aagcagccag gtcggcatag cggtaggact
     4081 gtctcgggct ggatacagcg gggcgctggc tgcttgggct ggcttcacgc tgccgtctgc
     4141 catagccttg atcctttttg cgctcggcat ctccagctat ggcgattacg tctcgcaggg
     4201 cgcgttgcat ggcttaaaag tggtggctgt ggccgtggtc gctcaagcag tatggggcat
     4261 ggcgcgtaac ctatgcacgg atgggctgcg agtcaccatc atggcaattg ctacctgcgt
     4321 cgttttactt gtgccgtccg cgtggggaca ggttggcgtg attgctatcg caggcatcgc
     4381 aggccggtta ttgttcaagc cagcgaaagt tgttgagcat gaccccctac ctatcacggt
     4441 cagtcaccgg gccggcgtgc tttggctctc gctgttcttt gtcttgctga ttggcctgcc
     4501 ggtgttggcc gaactgatgc caagtcaaac catggcaatg gtggattcct tctatcgtgt
     4561 cggatcactg gtgttcggcg gtggtcacgt tgtgctgcca ttactgcaag ccgaagtggt
     4621 gccctccggc tgggtcaaca atgaatcctt tctcgcgggg tacgggcagc tcaagcggtg
     4681 cccggccctt tgttcacgtt cgccgcgttt cttggtgcct cgatgaacac cgccccgtcg
     4741 ggctggatcg gcggcattgt gtgtctgctg gctatcttcg cgccctcgtt cttgctggtc
     4801 gtcggatcaa tgccattttg ggagcgtttg cgccgcaata caggcatcca agctgcgctg
     4861 gccgggatca atgccgctgt agtcggcttg ctgctggccg cgctgtatca gcctgtatgg
     4921 actagcgcca tctttcagcc gcaagacttc ggcttggcat tagttgccct tgtcgcactt
     4981 atgttctgga agctcccgcc gtggctggtt gtcctcggta gcggtgcagc tgggtggctg
     5041 ttgagcgtcg ctctgtgagg cacaaaaaat gactgacaaa gacctctacg gcggtttgat
     5101 ccgcctgcac atccttcacc atgcagccga ggaacctgtc tttgggctgg ggatcatcga
     5161 agagctacgc cgacacggct acgagatgag cgctggcacc gtgtacccga tgctgcacgg
     5221 cctggaaaaa aaaggctatc tgacctcacg ccacgaacgc accgggcgac gtgaacggcg
     5281 tgtttatgac atcactgaac aaggcagaac tgcacttgct gatgcgaaaa caaaggtcaa
     5341 ggagctgttc ggagagttgg tagaaggtgg ttgagttttt gcttctatgt caggttgagc
     5401 tataccctaa ctggattgtc attttcagaa gacgactgca ccagttgatt gggcgtaatg
     5461 gctgttgtgc agccagctcc tgacagttca atatcagaag tgatctgcac caatctcgac
     5521 tatgctcaat actcgtgtgg gctctgttgc aaaaatcgtg aagcttgagc atgcttggcg
     5581 gagattggac ggacggaacg atgacggatt tcaagtggcg ccatttccag ggtgatgtga
     5641 tcctgtgggc ggtgcgctgg tattgtcgct atccgatcag ctatcgcgac cttgaggaaa
     5701 tgctggcgga acgcggcatt tcggtcgacc atacgacgat ctatcgctgg gtccagtgct
     5761 acgccccgga gatggagaag cggctgcgct ggttctggcg gcgtggcttt gatccgagct
     5821 ggcgcctgga tgaaacctac gtcaaggtgc ggggcaagtg gacctacctg taccgggcag
     5881 tcgacaagcg gggcgacacg atcgatttct acctgtcgcc gacccgcagc gccaaggcag
     5941 cgaagcggtt cctgggcaag gccctgcgag gcctgaagca ctgggaaaag cctgccacgc
     6001 tcaataccga caaagcgccg agctatggtg cagcgatcac cgaattgaag cgcgaaggaa
     6061 agctggaccg ggagacggcc caccggcagg tgaagtatct caataacgtg atcgaggccg
     6121 atcacggaaa gctcaagata ctgatcaagc cggtgcgcgg tttcaaatcg atccccacgg
     6181 cctatgccac gatcaaggga ttcgaagtca tgcgagccct gcgcaaagga caggctcgcc
     6241 cctggtgcct gcagcccggc atcaggggcg aggtgcgcct tgtggagaga gcttttggca
     6301 ttgggccctc ggcgctgacg gaggccatgg gcatgctcaa ccaccatttc gcagcagccg
     6361 cctgatcggc gcagagcgac agcctacctc tgactgccgc caatctttgc aacagagccc
     6421 gccgtgctag tctgctcggt gatggtggag tgaagccaac ccgcaatcgg gttatgaatc
     6481 tgcatcgcga ttcgcaatca gctgtctctt gagcatgtcg aactcctgcg atgttatctc
     6541 gccgtgctcg tgctgctaca ccaacttgtc caactcatcc gccacaccgc tccccaccac
     6601 ctgcgatggc caggttgttt gctgggcgca ttggcggagt atcgtctcga cccgggacac
     6661 ccacaccggc acaaccttac gggagtgatt cactgtcaaa gaatcggccc ggtgctctga
     6721 cgcaagtatc gggatggtca ccatttgtaa gccgtagacc tgagtggtga tcaagacttc
     6781 gataccaccg accgtaccgg tactaatcga cgacggtcgt gttcgtcgcc tgccgcaggg
     6841 actctgcaca cctccgttta cgcatgtgcc tggaggagtt ggaaatcgtc gtgttcggga
     6901 aacattaaac acaggatggc agcgatctga gccagcacat gatcagctag ctcaccatcc
     6961 ggatcgacgg cccactgcat cgtcgcgcca gcgatgaccg agtgcaggag caactcagct
     7021 gccgcaggag cacctggggg cagtcgcttg cggatcccct ccaccaccgc gcggttccgc
     7081 tggatcgcaa gcgtgcgtag ctccggcacc tggagctcgt accaggagat gagatagttc
     7141 accgagaagt cgttgcgagt gttcatgctc cgaacgagca cctgcaaaaa ttcccagagc
     7201 ccttgcggcc ctgcgcctat cggtatcgca ttcaggtaat gccgcacctg ctcgacgccg
     7261 cgctccatca tcctcaccag cagcgtatcg cggttggtga agcgctggat taacgctgcg
     7321 cgggagagcc ccacctcctt tgctactccg ctgagcgtga actctatggg accgcaacgc
     7381 ttcagcacta cggtggcggc ctcgagtacc tcgtcatcgg acttgagctt ggggcggggc
     7441 atcagtgttc accttctgta tgggttgggg cggaggctgt ggctgccgcc gccattgtag
     7501 caaattgaag acggagcgag agtagagcca cgagccccgc aaacacggcc gatacaacga
     7561 ggccagggag cggaccagca aggtcgacaa acgcgccggc cgcaagcata accatgggcg
     7621 aggctgacag catcaccgcc gagaccgtgc cgagtacccg gccgagaagt ttctggcggc
     7681 gtgcggtttg tagatggcag cgttgagaat gggagagact gagccggtca gcagtcccac
     7741 gagcgcgccc aacaacatca gcaccggcac gcctggcaac tgtgaaagca gaagcgagcc
     7801 caccgcagag ccacaaaatg ccaccgccag ccagttctgc gctgatatcc gggcgccgac
     7861 cgacgcatga atggcaatgc caaggagacc accagccccc atcattgagg agaacagccc
     7921 gagctctgct acttggcgtc ctgcatctac aaacagcgca ggcatgatga cgctgccgtt
     7981 ggcgccaacg atgcccacga agatcatcac tataccaaag agagggcgca gcaggggttc
     8041 gctccagaga aaagcgacgc cggcgcgcat ggagagagtc gccgtcgtgg tcatcgtccg
     8101 agcggcacgc gcgggaagca cccacgcgcc gagcagacct gcaaggacgg agcagaacgc
     8161 cgtcagcccg agcgttggcg cagcgccaag caggccgatt gcggcccccc caagggccgg
     8221 gccacctaga atcgcgacgt tcccgatcac cgctttcagt gacgagacgc gctcaacgga
     8281 gagcccggcg acgtggccga gtttgggcag ctcactgtcc tgcgcggcca taccgggtgc
     8341 gtcgaacgcg gcaccgagca ccacgcaagc gatcagccca gtgttcgaga gggcgccaac
     8401 ggcatcgagc agtgggatgc tcgccatggc caccgccgcc caccacaccc gagatcaatg
     8461 cgacgggcgc gcgcccgaac cgatcgacga ggccaccacc aacccacgcg ccgatgatgg
     8521 tcgcgatgac gctgctagcg gccgtggcgc ccgcccaggc cgcgctcttt gtatgagaca
     8581 ggacgaacca tggaagcgcg agggccgcca ccgcgttgcc gatccggaag agaaaggtcg
     8641 ccgcgaacag cgtcgcgagc gggctatatc gacgttcgct cattccgctg cggcgagctg
     8701 cgccttcgcc gcagcgaggt actcttcgtt acccgagtcg agggcgaaga gtgcgtaggt
     8761 gaccgccccg aacgcaaggc gctccgcgat gtggtgggcg agccgcgcca cacccggcca
     8821 ccggccgctt catacgtgag gaggagcttc gcgagcccct cttcaccaaa gaccataagg
     8881 tgcgcggcca tgtcgatggc agggtcatca acgcgggcct cgctccagtc gatcatcccg
     8941 ctgacgcgct ccgtgttgtc gatgagcaca tggcccacgt agagatcgcc atgcaccacc
     9001 acggagaaat ctggccacga cgaatcgtcg tcgagccagc gctgccaccg gtggaggcgc
     9061 ttgtcgttca ccacgaactc gcgtcggacg cggtcaacgt cgtcggccac cttctgacgg
     9121 gcctgcgtcg gtgtacggat gagcatcccc gcatccacgg cggcggaaat ggggacggca
     9181 tgcagggcgg cgagcgcggt cgcgaagctc tccgcgaaga cctccgagtc ctgcggcacg
     9241 acccagtcgg gcgtggacga accaggctgg atgaccatcg cagtcgagtc ttcgagcatg
     9301 ggatagcaac gagctcgcgt tggccacgcg ccagtccggc accgcgaacg gcaggcgatt
     9361 cttgagcatt gccagcaccc gcgcctctgg ttcgaccttc gcgcttacct cggctcggcg
     9421 cgggatgcgc agcacccacc gacgtccatc gtcgacggtg gcgatcacga tcctatagtc
     9481 gagcccaagc tcattgacag tcagcgggcc atggagcttg agcccatgtc gggctgcaag
     9541 tgcgtacagt tgggaggtat cggcggtcgt gactacggtc atgattcact cctgagggct
     9601 tgacgggttt agccacctaa atgtaacagt cacgtcggtt atattcaatc cggcactgtt
     9661 gcaaagttag cgatgaggca gccttttgtc ttattcaaag gccttacatt tcaaaaactc
     9721 tgcttaccag gcgcatttcg cccaggggat caccataata aaatgctgag gcctggcctt
     9781 tgcgtagtgc acgcatcacc tcaatacctt tgatggtggc gtaagccgtc ttcatggatt
     9841 taaatcccag cgtggcgccg attatccgtt tcagtttgcc atgatcgcat tcaatcacgt
     9901 tgttccggta cttaatctgt cggtgttcaa cgtcagacgg gcaccggcct tcgcgtttga
     9961 gcagagcaag cgcgcgacca taggcgggcg gctttatccg tgttgatgaa tcgcgggatc
    10021 tgccacttct tcacgttgtt gaggatttta cccagaaacc ggtatgcagc tttgctgtta
    10081 cgacgggagg agagataaaa atcgacagtg cggccccggc tgtcgacggc ccggtacaga
    10141 tacgcccagc ggccattgac cttcacgtag gtttcatcca tgtgccacgg gcaaagatcg
    10201 gaagggttac gccagtacca gcgcagccgt tttttccatt tcaggcgcat aacgctgaac
    10261 ccagcggtaa atcgtggagt gatcgacatt cactccgcgt tcagccagca tctcctgcag
    10321 ctcacggtaa ctgatgccgt atttgcagta ccagcgtacg gcccacagaa tgatgtcacg
    10381 ctgaaatgcc ggcctttgaa tgggttcatg tgcagctcca tcagcaaagg gatgataagt
    10441 tttatcacca ccgactattt gcaacagtgc cccatcaggg acaaagatct ggctggtcgc
    10501 tggcatcacc gatatgagaa acggcttcaa cggcctggcg gcaaaggtgc agacgacgct
    10561 gaaagacgat ccgatgtcag gtcacgtttt tatcttccgt gggcgtaatg gcagtcaggt
    10621 aaagctcctc tggtctaccg gcgatggact gtgtctgctg accaaacggc tggagcgcgg
    10681 ccgcttcgcc tggccgtcag cccgggatgg caaagtgttc ctcacaccgg cacagctggc
    10741 gatgctcctt gaaggtatcg actggcggca gcctaaaaga ctgcttacgt ccctgactat
    10801 gttgtaagcc tctttatcct ggtcgacgct gaatgagcct ggtaatatac ccggtatgag
    10861 cagctcactt cctgacgata tcaatgcact gaaacgtctc cttgccgaac aggaggcgct
    10921 gaaccgtgcc ctgctggaaa agctgaacga gcgtgaacgc gaaatagacc atctgcaggc
    10981 gcagctggat aaactccgcc ggatgaactt cggcagtcgt tccgaaaaag tctcccgccg
    11041 tatcgcacaa atggaagccg atctgaaccg gcttcagaaa gagagcgata gagagcgata
    11101 cgctgactgg tagggtgtat gacccggcag tacagcgtcc gttgcgtcag acccgcaccc
    11161 gtaagccgtt ccctgaatca ctaccccgtg acgaaaagcg gctgttgcct gcggcgccgt
    11221 gctgcccgaa ctgcggcggt tactgagcta tctgggcgag gataccgccg aacagctgga
    11281 gttgatgcgt agcgccttcc gggttatccg gacggtacgg gaaaaacatg cctgtactca
    11341 gtgcgatgcc atcgtgcagg cacctgcacc ttcgcggccc atcgagcggg gtatcgccgg
    11401 accggggctg ctggcccgcg tgctgacctc gaagtatgca gagcacaccc cgctgtatcg
    11461 ccagtcagaa atatacggcc ggcaaggtgt ggagctgagc cgttcactgc tgtcgggctg
    11521 ggtggatgca tgctgccggc tgctgtctcc gctggaagag gcgcttcatg gctatgtgct
    11581 gactgacggt aagctccatg ctgatgacac gcctgtcccg gtgctgttgc caggcaataa
    11641 gaaaacgaag accgggcggt taggacctac gttcgtgacg accgtaacgc cgggtcaacg
    11701 ctggcgccgg cggtgtggtt cgcttacagc ccggacagaa aaggcatcca tccgcagacc
    11761 catcttgcgg ggttcagtgg tgtactgcag gcggatgctg tcacgaacgg tgcaatagtg
    11821 atccacaccc aacgcctgaa atcagatcca gggggtaatc tgctctcctg attcaggaga
    11881 gtttatggtc acttttgaga cagttatgga aattaaaatc ctgcacaagc agggaatgag
    11941 tagccggcga ttgccagaga actggggatc tcccgcaata ccgttaaacg ttatttgcag
    12001 gcaaaatctg agccgccaaa atatacgccg cgacctgctg ttgcttcact cctggatgaa
    12061 taccgggatt atattcgtca acgcatcgcc gatgctcatc cttacaaaat cccggcaacg
    12121 gtaatcgctc gcgagatcag agaccaggga tatcgtggcg gaatgaccat tctcagggat
    12181 tcattcgttc tctctcggtt cctcaggagc aggagcctgc cgttcggttc gaaactgaac
    12241 ccggacgaca gatgcaggtt gactggggca ctatgcgtca ccgctgccct caccgctatc
    12301 acgtttcagt tgctgttgct ccggatacag cctggaatgt ttgtacatcg aattcactga
    12361 caatatgcgt tatgacacgc tggagacctg ccatcgtaat gcgttccgct tctttggtgg
    12421 tgtgccgcgc gaagtgttgt atgacaatat gaaaactgtg gttctgcaac gtgacgcata
    12481 tcagaccggt cagcaccggt tccatccttc gcctgtggca gttcggcaag gagatgggct
    12541 tctctccccg actgtgtcgc cccttcaggg cacagactaa aggtaaggtg gaacggatgg
    12601 tgcagtacac ccgtaacagt ttttacattc cactaatgac tcgcctgcgc ccgatgggga
    12661 tcactgtcga tgttgaaaca gccaaccgcc acggtctgcg ctggctgcac gatgtcgcta
    12721 accaacgaaa gcatgaaaca atccaggccc gtccctgcga tcgctggctc gaagagcagc
    12781 agtccatgct ggcactgcct ccggagaaaa aagagtatga cgtgcatcct ggtgaaaatc
    12841 tggtgaactt cgacaaacac cccctgcatc atccactctc catctacgac tcattctgca
    12901 gaggagtggc gtgatgatgg aactgcaaca tcaacgactg atggcgctcg ccgggcagtt
    12961 gcaactggaa agccttataa gcgcagcgcc tgcgctgtca caacaggcag tagaccagga
    13021 atggagttat atggacttcc tggagcatct gcttcatgaa gaaaaactgg cacgtcatca
    13081 acgtaaacag gcgatgtata cccgaatggc agccttcccg gcggtgaaaa cgttcgaaga
    13141 gtatgacttc acattcgcca ccggagcacc gcagaagcaa ctccagtcgt tacgctcact
    13201 cagcttcata gaacgtaatg aaaatatcgt attactgggg ccatcaggtg tggggaaaac
    13261 ccatctggca atagcgatgg gctatgaagc agtccgtgca ggtatcaaag ttcgcttcac
    13321 aacagcagca gatctgttac ttcagttatc tacggcacaa cgtcagggcc gttataaaac
    13381 gacgcttcag cgtggagtaa tggccccccg cctgctcatc attgatgaaa taggctatct
    13441 gccgttcagt caggaagaag caaagctgtt cttccaggtc atcgctaaac gttacgaaaa
    13501 gagcgcaatg atcctgacat ccaatctgcc gttcgggcag tgggatcaaa cgttcgccgg
    13561 tgatgcagca ctgacctcag cgatgctgga ccgtatctta caccactcac atgtcgttca
    13621 aatcaaagga gaaagctatc gactcagaca gaaacgaaag gccggggtta tagcagaagc
    13681 taatcctgag taaaacggtg gatcaatatt gggccgttgg tggagatata agtggatcac
    13741 ttttcatccg tcgttgacag gatgcatacg ccgggttcaa cgagctgtac cgggatggcc
    13801 ggataacgga agccgcctgt tgggctcacg cccgccgtaa aatccacgat gtgcacgttc
    13861 gcaccccgtc agccctgacg gaggaagcgc tgaaacggat cggcgaactg tacgccatcg
    13921 aggcagagat aaggggaatg acggcggagc aacgccttgc cgaacgtcag ttgaaaacga
    13981 aaccgctgct gaaatccctg gaaagctggc tgcgtgaaaa gatgaaaacc ctgtcgcgac
    14041 actcagaact ggcgaaagcg ttcgcatacg ccctgaacca gtggccggcg ctgacgtact
    14101 atgcagatga tggctgggct gaggcggaca ataacatcgc tgaaaatgcg ttgcggatgg
    14161 tcagtctggg ccgcaaaaac tacctgttct tcggttcgga tcatggagga gagcggggag
    14221 cgctgctgta cagcctgatc gggacgtgca aactgaacgg agtggagcca gaaagctacc
    14281 tccgctatgt ccttgacgtc atagccgact ggccgataaa ccgggtcggc gaactgctcc
    14341 cctggcgcgt agcactgccg actgaataac acatccccgt caatacggtt cttgctgcac
    14401 gcttacaatt tcagggcagg gaatagtatt gttaatttcg ggagaaactt aaagttgcca
    14461 catcgacagt ttcatcacac aggcttttgt cctgaaaact tttcttattt tggactttcg
    14521 ccagccactg tccaatatga agagaaggta ctgtgacgat accatcctca ttagttacaa
    14581 aggtgagttc tgctttatga acaggatgtt tgtgctcaac tgcatgagta tgacgggatg
    14641 atttcagata actgaccgag tcaagctcca tgatagctcc ggcgagcggg gacgttttat
    14701 acaggacttt cagcttcaca tcttcactga aacgacttat atcggataac ggaatgattt
    14761 caagctcatg ccccgttgga gactgataga gttgtgctgg catctgctgt tcaccaggaa
    14821 taaaagattt cgcatattta gtgacaaact cacagtaagc cacatcattt ctgccctccc
    14881 ggctgaccgg tttccatcct gaagaggttc tcgaccagta tcccggtttc atatatgttg
    14941 acaaaacgta gccattatct ttgcttgcag actcagtttt atagacataa tccgtggacg
    15001 ctggcttcag tgttattgtc tctttcccgt tataaatccg gggattttca aagaaattcc
    15061 ttctgtcagg aattgtgccc tttgagggga aattatgacc ataaccaatc tctgcggtaa
    15121 tgttgttctc tgcctgttta cctgtaatcc agacatcgtg ggccaggaca tgccccgatg
    15181 ctgtcagaca aagagctaag atataacctg tatttttcat catgatttgt taccactgat
    15241 aacgggtata aagactgaca gttctgcctg aaagcggcac tcctttgcca ttcatggcaa
    15301 gcttgttgaa ggcattatcc agagccactg atgcctcaaa gcctttaaca cttacaggct
    15361 tataagacag tgaaaaggaa tgtacggcat agccagcctg atggggatcg ccttttttca
    15421 catgcgtggc tgctgccgaa agttcagcac gccatccggc agaaactcct ccatgaccaa
    15481 caggtatact tatgtcactg atgagtgtgt caggattgcc ggagcccagc cattccctgc
    15541 tgctggcatc catactttcc gtgcggttat aagaaagcat ccagtcaaaa taatcagact
    15601 ggtaatttcc ctgcatatcc catccccaga tacgggcccg ggatacatta taagaataag
    15661 aacgcatccg tttcatatcc acgcgcgtgg caatatagtt tctggcatcc gttccgaaat
    15721 atccgccttt caactgcagc cgatcattgc ctgtaagcag gccgtccagt tgaatacctg
    15781 cgccaatctc acgggtaatg ttattttctg gtttcagatt aaggttaggt acccagtaat
    15841 ggcactgttg caaatagtcg gtggtgataa acttatcatc cccttttgct gatggagctg
    15901 cacatgaacc cattcaaagg ccggcatttt cagcgtgaca tcattctgtg ggccgtacgc
    15961 tggtactgca aatacggcat cagttaccgt gagctgcagg agatgctggc tgaacgcgga
    16021 gtgaatgtcg atcactccac gatttaccgc tgggttcagc gttatgcgcc tgaaatggaa
    16081 aaacggctgc gctggtactg gcgtaaccct tccgatcttt gcccgtggca catggatgaa
    16141 acctacgtga aggtcaatgg ccgctgggcg tatctgtacc gggccgtcga cagccggggc
    16201 cgcactgtcg atttttatct ctcctcccgt cgtaacagca aagctgcata ccggtttctg
    16261 ggtaaaatcc tcaacaacgt gaagaagtgg cagatcccac gattcatcaa cacggataaa
    16321 gcgcccgcct atggtcgcgc gcttgctctg ctcaaacgcg aaggccggtg cccgtctgac
    16381 gttgaacacc gacagattaa gtaccggaac aacgtgattg aatgcgatca tggcaaactg
    16441 aaacggataa tcaacgccac gctgggattt aaatccatga agacggctta cgccaccatc
    16501 aaaggtattg aggtgatgcg tgcactacgc aaaggccagg cctcagcatt ttattatggt
    16561 gatcccctgg gcgaaatgcg cctggtaagc agagtttttg aaatgtaagg cctttgaata
    16621 agacaaaagg ctgcctcatc gctaactttg caacagtgcc ctcggcccct tccggcgtga
    16681 aggcggcatc gagcgggatt tccttgcagc acacgcagca actggtgctc ggttcattgg
    16741 cgttcatggt ggtgttcctc cattggttga cgaagccgac gaaggccgcc gccggcatcg
    16801 gcctggcgaa caggaaaccc tgcaccgtgt cgcaacccgc ctgccgcaac cacgcaaggc
    16861 agtcgggtgt ttccacaccc tcggctacca cctccattgt cgttttcaga agacggctgc
    16921 actgaacgtc agaagccgac tgcactatag cagcggaggg gttggatcca tcaggcaacg
    16981 acgggctgct gccggccatc agcggacgca gggaggactt tccgcaaccg gccgttcgat
    17041 gcggcaccga tggccttcgc gcaggggtag tgaatccgcc aggattgact tgcgctgccc
    17101 tacctctcac tagtgagggg cggcagcgca tcaagcggtg agcgcactcc ggcaccgcca
    17161 actttcagca catgcgtgta aatcatcgtc gtagagacgt cggaatggcc gagcagatcc
    17221 tgcacggttc gaatgtcgta accgctgcgg agcaaggccg tcgcgaacga gtggcggagg
    17281 gtgtgcggtg tggcgggctt cgtgatgcct gcttgttcta cggcacgttt gaaggcgcgc
    17341 tgaaaggtct ggtcatacat gtgatggcga cgcacgacac cgctccgtgg atcggtcgaa
    17401 tgcgtgtgct gcgcaaaaac ccagaaccac ggccaggaat gcccggcgcg cggatacttc
    17461 cgctcaaggg cgtcgggaag cgcaacgccg ctgcggccct cggcctggtc cttcagccac
    17521 catgcccgtg cacgcgacag ctgctcgcgc aggctgggtg ccaagctctc gggtaacatc
    17581 aaggcccgat ccttggagcc cttgccctcc cgcacgatga tcgtgccgtg atcgaaatcc
    17641 agatccttga cccgcagttg caaaccctca ctgatcc
//
