LOCUS       CP088459               25349 bp    DNA     circular BCT 09-DEC-2021
DEFINITION  Escherichia coli strain F16EC0024 plasmid pF16EC0024-3, complete
            sequence.
ACCESSION   CP088459
VERSION     CP088459.1
DBLINK      BioProject: PRJNA782071
            BioSample: SAMN23391676
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 25349)
  AUTHORS   Yoon,E.-J., Choi,Y.J., Kim,D., Won,D., Choi,J.R. and Jeong,S.H.
  TITLE     Chromosomal integration and amplification of group 9 blaCTX-M genes
            in Escherichia coli expand the spectrum of resistance under
            antimicrobial pressure
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 25349)
  AUTHORS   Yoon,E.-J., Choi,Y.J., Kim,D., Won,D., Choi,J.R. and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-NOV-2021) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, Gangnam Severance Hospital,
            Yonsei, Seoul 06273, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: other: SMRTLink v. v9.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 180x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 12/02/2021 11:41:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 5.3
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,213
            CDSs (total)                      :: 5,099
            Genes (coding)                    :: 4,853
            CDSs (with protein)               :: 4,853
            Genes (RNA)                       :: 114
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 6
            Pseudo Genes (total)              :: 246
            CDSs (without protein)            :: 246
            Pseudo Genes (ambiguous residues) :: 0 of 246
            Pseudo Genes (frameshifted)       :: 107 of 246
            Pseudo Genes (incomplete)         :: 155 of 246
            Pseudo Genes (internal stop)      :: 61 of 246
            Pseudo Genes (multiple problems)  :: 64 of 246
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..25349
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="F16EC0024"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:562"
                     /plasmid="pF16EC0024-3"
                     /geo_loc_name="South Korea"
                     /lat_lon="35.18 N 129.08 E"
                     /collection_date="2016"
                     /collected_by="Kor-GLASS"
     gene            complement(join(25297..25349,1..127))
                     /locus_tag="LQR18_25895"
     CDS             complement(join(25297..25349,1..127))
                     /locus_tag="LQR18_25895"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UGE64553.1"
                     /translation="MAAAESAEKAAEDELVKVNQDGVVGKAEAERLTELNAGGDSGGQF
                     RAWQNMDICGDIRF"
                     /name="hypothetical protein"
     gene            complement(79..4980)
                     /locus_tag="LQR18_25900"
     CDS             complement(79..4980)
                     /locus_tag="LQR18_25900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000781915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UGE64554.1"
                     /translation="MKMIFTGKVSGEKTVLAAGARHTVKAQAGEQYGLVDEVTGLVPDG
                     MEADRSGDDLILRKKEDSTEVRIEGFWEECQPGETQCTAVFNVVGENGQVTEAVLTQDG
                     PVLENFTAGQSGTLAGGINNGIIWGGIAFGTGLAAIALAAGGGSGSSRHKRTAEGEQKP
                     VQPEGGQETGEVEAKVAAAESAEKAAEDELVKVNQDGVVGKAEAERLTELNAAVTAAKA
                     DAQQAVDGLQDGPVKTGFSERLDKLDGIKVPAVTDANDDGVADDKAAEVEAKVAAAESA
                     EKAAEDELVKVNQDGVVGKAEAERLTELNAAVTAAKADAQQAVDGLQDGPVKTGFSERL
                     DKLDGIKVPAVTDANDDGVADDKAAEVEAKVAAAESAEKAAEDELVKVNQDGVVGKAEA
                     ERLTELNAAVTAAKADAQQAVDGLQDGPVKTGFSERLDKLDGIKVPAVTDANDDGVADD
                     KAAEVEAKVAAAESAEKAAEDELVKVNQDGVVGKAEAERLTELNAAVTAAKADAQQAVD
                     GLQDGPVKTGFSERLDKLDGIKVPAVTDANDDGVADDKAAEVEAKVAAAESAEKAAEDE
                     LVKVNQDGVVGKAEAERLTELNAAVTAAKADAQQAVDGLQDGPVKTGFSERLDKLDGIK
                     VPAVTDANDDGVADDKAAEVEAKVAAAESAEKAAEDELVKVNQDGVVGKAEAERLTELN
                     AAVTAAKADAQQAVDGLQDGPVKTGFSERLDKLDGIKVPAVTDANDDGVADDKAAEVEA
                     KVAAAESAEKAAEDELVKVNQDGVVGKAEAERLTELNAAVTAAKADAQQAVDGLQDGPV
                     KTGFSERLDKLDGIKVPAVTDANDDGVADDKAAEVEAKVAAAESAEKAAEDELVKVNQD
                     GVVGKAEAERLTELNAAVTAAKADAQQAVDGLQDGPVKTGFSERLDKLDGIKVPAVTDA
                     NDDGVADDKAAEVEAKVAAAESAEKAAEDELVKVNQDGVVGKAEAERLTELNAAVTAAK
                     ADAQQAVDGLQDGPVKTGFSERLDKLDGIKVPAVTDANDDGVADDKAAEVEAKVAAAES
                     AEKAAEDELVKVNQDGVVGKAEAERLTELNAAVTAAKADAQQAVDGLQDGPVKTGFSER
                     LDKLDGIKVPAVTDANDDGVADDKAAEVEAKVAAAESAEKAAEDELVKVNQDGVVGKAE
                     AERLTELNAAVTAAKADAQQAVDGLQDGPVKTGFSERLDKLDGIKVPAVTDANDDGVAD
                     DKAAEVEAKVAAAESAEKAAEDELVKVNQDGVVGKAEAERLTELNAAVTAAKADAQQAV
                     DGLQDGPVKTGFSERLDKLDGIKVPAVTDANDDGVADDKAAEVEAKVAAAESAEKAAED
                     ELVKVNQDGVVGKAEAERLTELNAAVTAAKADAQQAVDGLQDGPVKTGFSERLDKLDGI
                     KVPAVTDANDDGVADDKAAEVEAKVAAAESAEKAAEDELVKVNQDGVVGKAEAERLTEL
                     NAAVTAAKADAQQAVDGLQDGPVKTGFSERLDKLDGIKVPAVTDANDDGVADDKAAEVE
                     AKVAAAESAEKAAEDELVKVNQDGVVGKAEAERLTELNAAVTAAKADAQQAVDGLQDGP
                     VKTGFSERLDKLDGIKVPAVTDANDDGVADDKAAEVKQKWLPQSLQRKPRKMNW"
                     /name="hypothetical protein"
     gene            complement(5255..6502)
                     /locus_tag="LQR18_25905"
     CDS             complement(5255..6502)
                     /locus_tag="LQR18_25905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001380656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyD family type I secretion periplasmic adaptor
                     subunit"
                     /protein_id="UGE64555.1"
                     /translation="MTEKMERNKASSEVVRQSDLALLTDVQAALQQEKHHALFLMVIFL
                     LVLVVTFIIWAWNSPLDEVTRGQGSIIPGSREQVIQTLDPGILKTLEVREGDIVDKGQV
                     LLTLDDTRSSAMLRESEARVNNLEAVRARLRAEAYSESLTFPDNVPEDLRERESTVYFL
                     RKTELAQSIAGLKQSKALLDREIAMTRPIVREGAMSEVELLRMQRQSAELQLQIDEKQN
                     KYLTEAGSELVKTETDLAQAKENMAGRADPVERSRLRAPLRGIVKNIRVNTLGGVVSAG
                     QDIMEIIPLEDQLLIEAYINPRDVAYVRTGMPALVKLTAYDYAIYGGLDGVVTLVSPDT
                     LRDQKRPGDLKLDPNEAYYRVLVTTSNNYLTDRNGKKLPVIPGMIASVDIKTGRKTVFQ
                     YLIKPITRMKQALQER"
                     /name="HlyD family type I secretion periplasmic adaptor
                     subunit"
     gene            complement(6562..8709)
                     /locus_tag="LQR18_25910"
     CDS             complement(6562..8709)
                     /locus_tag="LQR18_25910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001620877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I secretion system permease/ATPase"
                     /protein_id="UGE64556.1"
                     /translation="MKSIFEGLSQVTALLGTPVSAEALAASTVRTDVSGIDFRSVGEFL
                     RSEGFDNHLSRRALEDIPSLAVPVLLLLNAQEAIVVVRIRGTGLTREYHVLQPGGLRNK
                     LSHEALMAVYSGYCWFVQPQATQDRRSDLPEYDMSGGWFWRVLWRFRPYYGQVILASFI
                     INFLALVSSLYVMNVYDRVIPNRSWETLWMLSIGVIAAILFECAAKLIRSYLTDIAGKK
                     ADLIISSALLRRVMAVKMSDRPASSGSYASNLREYESVREFMTSATLLAFVDLPFILLF
                     IGVIGLVGGWLAVVPLTLVPLVILAGILLQRPLSRHINASMRESSQRQGLLVEALDGIE
                     TLKLNNAVNWVQRRWDGYTASVARSSIRVKNTSNVIICFSIAVQQLNTVLLVILGTYLI
                     HNDDPHNRITMGALIAAVILSGRALAPLGQIASLATRFQQARLAMQGVNEIVRRPVERE
                     RQTHYLTVKDIQGEFRFSDVSFSYKSGLPEALSGLSLSIRPGERVGIIGAIGCGKSTLL
                     KMMVGLYRQNRGQITLDGVALQQLDPSFVRDKVFLLEQNPRLFLGTLRENLQLSRLPGS
                     LSDVDMINAAGRFGFDRFIRHHPRGLDMQIGEGGLGLSGGQRQMVALTRMVLSSPRVVL
                     LDEPTTGLDLQTESVVLKGLSHWTRGRTMVVVTHRLQVLNIVDRIVVMNEGRVMMDGSR
                     DEILKKLSGKQQNDGNRPAAS"
                     /name="type I secretion system permease/ATPase"
     gene            complement(8706..9890)
                     /locus_tag="LQR18_25915"
     CDS             complement(8706..9890)
                     /locus_tag="LQR18_25915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001774322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TolC family protein"
                     /protein_id="UGE64557.1"
                     /translation="MNDPAVMEARAELNSAQSRTEQARSAHWPVITATGSKLLSQSHRY
                     SYDYDSEDILPGIRGEVNIFASGAIEADVRRSESEAEYYYYKVKETGEERIRSFVSLYL
                     DALREKQSIEVLKQSLSRHNSILNDLNTISIHDTGRESEFVQADARRLMIRQQLNTRNR
                     VLKSTLGKLSTWTINPVTEADLENPFSLMTESRLLTDFTQAPQTGNPSWLASQADVESK
                     KAALRAQELARYPRIDLTGSVTQDDRQIGVNLSWDLFNRNASYGVSEKAAQIAAATGRR
                     DSVARLIDETGRLSLITVRESRVEMETLRRQEQASAKVVDFYRLQFRVARKTLIELLNA
                     ENELYSVGLSRVQTEDQMLHGMLDYLYSQGMLLKWSGVNLSDAKNNGAEGQVNK"
                     /name="TolC family protein"
     gene            complement(10032..10334)
                     /locus_tag="LQR18_25920"
     CDS             complement(10032..10334)
                     /locus_tag="LQR18_25920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001620873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adhesin biosynthesis transcription regulatory
                     family protein"
                     /protein_id="UGE64558.1"
                     /translation="MFMKLDEHILRHTLSCYRCSVKLTAANICNEHFWLLIELSGVRSE
                     KIIMSLKDYLVDGFSKKEACEKNSVSLSYFSVTLKKLSYINNISALLSEYYHGDF"
                     /name="adhesin biosynthesis transcription regulatory family
                     protein"
     gene            10874..12022
                     /locus_tag="LQR18_25925"
                     /pseudo=""
     CDS             10874..12022
                     /locus_tag="LQR18_25925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612101.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /name="IS3 family transposase"
     gene            12216..12505
                     /locus_tag="LQR18_25930"
                     /pseudo=""
     CDS             12216..12505
                     /locus_tag="LQR18_25930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611435.1"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /name="IS3 family transposase"
     gene            12882..13634
                     /locus_tag="LQR18_25935"
     CDS             12882..13634
                     /locus_tag="LQR18_25935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000471454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fimbria/pilus periplasmic chaperone"
                     /protein_id="UGE64549.1"
                     /translation="MFKAIFTVGSLLLPCIVVAKGIGVTASSNDVVDAQLFSVDLNLNR
                     VVYYHGSLGENVAVKNNQAYPMLVQSMVFDEDKKSSAPFITTPPLFRLDGSQTSRIRIV
                     RTGGEFPQDREKLQWLCVKGIPPQSEDKWAEGTITKNSSFTVQFSVNNCIKVFVRPDTI
                     KGHPEDFADKVTWSKKGTTVLEANNPTPFYLNIKELNIGGRSIKSPNYIPPFGKQSFSI
                     PGSSVGKIQWRIVTDYGGDSKIYQSEGK"
                     /name="fimbria/pilus periplasmic chaperone"
     gene            13778..14279
                     /locus_tag="LQR18_25940"
                     /pseudo=""
     CDS             13778..14279
                     /locus_tag="LQR18_25940"
                     /inference="COORDINATES: protein motif:HMM:NF025320.2"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            14276..15853
                     /locus_tag="LQR18_25945"
                     /pseudo=""
     CDS             14276..15853
                     /locus_tag="LQR18_25945"
                     /inference="COORDINATES: protein motif:HMM:NF012786.2"
                     /note="frameshifted; internal stop; incomplete; partial on
                     complete genome; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="fimbria/pilus outer membrane usher protein"
                     /name="fimbria/pilus outer membrane usher protein"
     gene            16010..16144
                     /locus_tag="LQR18_25950"
     CDS             16010..16144
                     /locus_tag="LQR18_25950"
                     /inference="COORDINATES: protein motif:HMM:NF025319.2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UGE64559.1"
                     /translation="MVSSATADDNKRVVGIVNESGEVYMSGLSEKRTTGCEMEQSWKL"
                     /name="hypothetical protein"
     gene            17689..18104
                     /locus_tag="LQR18_25955"
                     /pseudo=""
     CDS             17689..18104
                     /locus_tag="LQR18_25955"
                     /inference="COORDINATES: protein motif:HMM:NF018659.2"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="SdiA-regulated domain-containing protein"
                     /name="SdiA-regulated domain-containing protein"
     gene            complement(18282..19670)
                     /gene="ltrA"
                     /locus_tag="LQR18_25960"
     CDS             complement(18282..19670)
                     /gene="ltrA"
                     /locus_tag="LQR18_25960"
                     /EC_number="2.7.7.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001608718.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
                     /protein_id="UGE64550.1"
                     /translation="MMINEAQAQATAASGRGDGRYPSGLHDGAEISTAAGGQTKAEVPL
                     TMEAVITRENLMLAYQRVVENKGAAGVDNLSVAELKPWLKKNWRSVRQALIDGNYQPRA
                     IRRMDIPKPDGGVRTLGIPTVVDRLIQQAIAQQLSAIVDKSFSDSSYGFRPGRNAWQAV
                     QQAQRYIRGGKRWVVDMDLEKFFDRVDHRLLMTRLARTIKDRRVLRLIRRYLKAEIVRD
                     GQREKRQEGMPQGGPLSPLLSNILLDELDKELERRGHSFCRYADDCNIYLSSRKAGEHL
                     LKNIRAFVENKLKLKVNEKKSAVARPWERKFLGYSVTWHKQAKLKIALTSVNRLKEKVR
                     SLTTGNRSKSVKATINALMPVLRGWISYFRLTEVRGVLEELDGWIKRKLRCLLWRQWKR
                     PGTRTKNLQRAGLSKDSAMISAYNNHGPWWNSGSSHMNQAIKNAWFSRQGLISLLEQQR
                     QFQC"
                     /name="ltrA"
     gene            complement(20227..20958)
                     /locus_tag="LQR18_25965"
     CDS             complement(20227..20958)
                     /locus_tag="LQR18_25965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000456855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="UGE64551.1"
                     /translation="MYTNKCTLHVTYGNEHLTIKEGCIAFFEKHIEINISIIKRTNTET
                     NPFEVISINNDLLSKVLTIMDPIYSFSFGQMQRKRRLQQRIFMIDGDIISTEIFKSIKS
                     MKVCNEKVYKLACLFSIIDNECDFFSSICVSTSISFTDKVKKIIECDFEKKWKLSDISE
                     EMNMSEVAVRKNLENENITFQQVLLDSKMNYAAKLILNSKNHINNVSKLIGMSSTSYFI
                     KLFNSYYGVTPKKFYFYHKSS"
                     /name="AraC family transcriptional regulator"
     gene            complement(21293..22308)
                     /locus_tag="LQR18_25970"
                     /pseudo=""
     CDS             complement(21293..22308)
                     /locus_tag="LQR18_25970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767745.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /name="IS3 family transposase"
     gene            22437..23590
                     /locus_tag="LQR18_25975"
     CDS             join(22437..22698,22698..23590)
                     /locus_tag="LQR18_25975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612091.1"
                     /ribosomal_slippage=""
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="UGE64552.1"
                     /translation="MTKPVSISKKPRNQHTPEFRNEALKLAERIGVAAAARELSLYESQ
                     LYARRSKQQQQMSSSERESELAAENVRLKRQLAEQAEELAILPKGRDILREAPEMKYVF
                     IENHRAEFSIKAMCRVLRVARSGWYVWLRRRHQMSLRQQFRLTCDAAVHKAFFEAKQRY
                     GAPRLADELPEFNIKTIAASLRRQGLRAKACRKFSPVSYRAHGLPVLENLLEQDYSAPV
                     ARNQKWAGDITYLRTDEGWLYLAVVIDLRSRAVIGWSMSPRMTAQLACDALQMALWRRR
                     RPESVIVHTDRGGQYCSGDYQALLKRHNLRGSMSAKGYCYDNACVESFFHSLKVECIHG
                     ERFSSQEIMRATVFNYIESDYNRWRRHSACGGLSPEQFENHNLA"
                     /name="IS3 family transposase"
     gene            complement(24054..25244)
                     /gene="senB"
                     /locus_tag="LQR18_25980"
     ARG             complement(24058..25220)
                     /name="senB"
                     /gene="senB"
                     /gene_name="enterotoxin production-related protein TieB"
                     /tool="amrfinderplus"
                     /drug_class="nan"
                     /identity="99.48"
                     /coverage="99.23"
ORIGIN
        1 cgccgctgtc accgccagca ttcagctccg tcagacgctc ggcttcagct ttacccacca
       61 cgccgtcctg gttcactttc accagttcat cttccgcggc tttctctgca gactctgcgg
      121 cagccacttt tgcttcacct cggcagcctt gtcatcagcc acgccatcgt cgttcgcatc
      181 cgtcaccgcc ggtaccttga tcccgtccag tttatccaga cgctcactga agcccgtctt
      241 gaccggacca tcctgcagac catccaccgc ctgctgggca tcggctttcg ccgctgtcac
      301 cgcagcattc agctccgtca gacgctcggc ttcagcttta cccaccacgc cgtcctggtt
      361 cactttcacc agttcatctt ccgcggcttt ctctgcagac tctgcggcag ccacttttgc
      421 ttcaacctcg gcagccttgt catcagccac gccatcgtcg ttcgcatccg tcaccgccgg
      481 taccttgatc ccgtccagtt tatccagacg ctcactgaag cccgtcttga ccggaccatc
      541 ctgcagacca tccaccgcct gctgggcatc ggctttcgcc gctgtcaccg cagcattcag
      601 ctccgtcaga cgctcggctt cagctttacc caccacgccg tcctggttca ctttcaccag
      661 ttcatcttcc gcggctttct ctgcagactc tgcggcagcc acttttgctt caacctcggc
      721 agccttgtca tcagccacgc catcgtcgtt cgcatccgtc accgccggta ccttgatccc
      781 gtccagttta tccagacgct cactgaagcc cgtcttgacc ggaccatcct gcagaccatc
      841 caccgcctgc tgggcatcgg ctttcgccgc tgtcaccgca gcattcagct ccgtcagacg
      901 ctcggcttca gctttaccca ccacgccgtc ctggttcact ttcaccagtt catcttccgc
      961 ggctttctct gcagactctg cggcagccac ttttgcttca acctcggcag ccttgtcatc
     1021 agccacgcca tcgtcgttcg catccgtcac cgccggtacc ttgatcccgt ccagtttatc
     1081 cagacgctca ctgaagcccg tcttgaccgg accatcctgc agaccatcca ccgcctgctg
     1141 ggcatcggct ttcgccgctg tcaccgcagc attcagctcc gtcagacgct cggcttcagc
     1201 tttacccacc acgccgtcct ggttcacttt caccagttca tcttccgcgg ctttctctgc
     1261 agactctgcg gcagccactt ttgcttcaac ctcggcagcc ttgtcatcag ccacgccatc
     1321 gtcgttcgca tccgtcaccg ccggtacctt gatcccgtcc agtttatcca gacgctcact
     1381 gaagcccgtc ttgaccggac catcctgcag accatccacc gcctgctggg catcggcttt
     1441 cgccgctgtc accgcagcat tcagctccgt cagacgctcg gcttcagctt tacccaccac
     1501 gccgtcctgg ttcactttca ccagttcatc ttccgcggct ttctctgcag actctgcggc
     1561 agccactttt gcttcaacct cggcagcctt gtcatcagcc acgccatcgt cgttcgcatc
     1621 cgtcaccgcc ggtaccttga tcccgtccag tttatccaga cgctcactga agcccgtctt
     1681 gaccggacca tcctgcagac catccaccgc ctgctgggca tcggctttcg ccgctgtcac
     1741 cgcagcattc agctccgtca gacgctcggc ttcagcttta cccaccacgc cgtcctggtt
     1801 cactttcacc agttcatctt ccgcggcttt ctctgcagac tctgcggcag ccacttttgc
     1861 ttcaacctcg gcagccttgt catcagccac gccatcgtcg ttcgcatccg tcaccgccgg
     1921 taccttgatc ccgtccagtt tatccagacg ctcactgaag cccgtcttga ccggaccatc
     1981 ctgcagacca tccaccgcct gctgggcatc ggctttcgcc gctgtcaccg cagcattcag
     2041 ctccgtcaga cgctcggctt cagctttacc caccacgccg tcctggttca ctttcaccag
     2101 ttcatcttcc gcggctttct ctgcagactc tgcggcagcc acttttgctt caacctcggc
     2161 agccttgtca tcagccacgc catcgtcgtt cgcatccgtc accgccggta ccttgatccc
     2221 gtccagttta tccagacgct cactgaagcc cgtcttgacc ggaccatcct gcagaccatc
     2281 caccgcctgc tgggcatcgg ctttcgccgc tgtcaccgca gcattcagct ccgtcagacg
     2341 ctcggcttca gctttaccca ccacgccgtc ctggttcact ttcaccagtt catcttccgc
     2401 ggctttctct gcagactctg cggcagccac ttttgcttca acctcggcag ccttgtcatc
     2461 agccacgcca tcgtcgttcg catccgtcac cgccggtacc ttgatcccgt ccagtttatc
     2521 cagacgctca ctgaagcccg tcttgaccgg accatcctgc agaccatcca ccgcctgctg
     2581 ggcatcggct ttcgccgctg tcaccgcagc attcagctcc gtcagacgct cggcttcagc
     2641 tttacccacc acgccgtcct ggttcacttt caccagttca tcttccgcgg ctttctctgc
     2701 agactctgcg gcagccactt ttgcttcaac ctcggcagcc ttgtcatcag ccacgccatc
     2761 gtcgttcgca tccgtcaccg ccggtacctt gatcccgtcc agtttatcca gacgctcact
     2821 gaagcccgtc ttgaccggac catcctgcag accatccacc gcctgctggg catcggcttt
     2881 cgccgctgtc accgcagcat tcagctccgt cagacgctcg gcttcagctt tacccaccac
     2941 gccgtcctgg ttcactttca ccagttcatc ttccgcggct ttctctgcag actctgcggc
     3001 agccactttt gcttcaacct cggcagcctt gtcatcagcc acgccatcgt cgttcgcatc
     3061 cgtcaccgcc ggtaccttga tcccgtccag tttatccaga cgctcactga agcccgtctt
     3121 gaccggacca tcctgcagac catccaccgc ctgctgggca tcggctttcg ccgctgtcac
     3181 cgcagcattc agctccgtca gacgctcggc ttcagcttta cccaccacgc cgtcctggtt
     3241 cactttcacc agttcatctt ccgcggcttt ctctgcagac tctgcggcag ccacttttgc
     3301 ttcaacctcg gcagccttgt catcagccac gccatcgtcg ttcgcatccg tcaccgccgg
     3361 taccttgatc ccgtccagtt tatccagacg ctcactgaag cccgtcttga ccggaccatc
     3421 ctgcagacca tccaccgcct gctgggcatc ggctttcgcc gctgtcaccg cagcattcag
     3481 ctccgtcaga cgctcggctt cagctttacc caccacgccg tcctggttca ctttcaccag
     3541 ttcatcttcc gcggctttct ctgcagactc tgcggcagcc acttttgctt caacctcggc
     3601 agccttgtca tcagccacgc catcgtcgtt cgcatccgtc accgccggta ccttgatccc
     3661 gtccagttta tccagacgct cactgaagcc cgtcttgacc ggaccatcct gcagaccatc
     3721 caccgcctgc tgggcatcgg ctttcgccgc tgtcaccgca gcattcagct ccgtcagacg
     3781 ctcggcttca gctttaccca ccacgccgtc ctggttcact ttcaccagtt catcttccgc
     3841 ggctttctct gcagactctg cggcagccac ttttgcttca acctcggcag ccttgtcatc
     3901 agccacgcca tcgtcgttcg catccgtcac cgccggtacc ttgatcccgt ccagtttatc
     3961 cagacgctca ctgaagcccg tcttgaccgg accatcctgc agaccatcca ccgcctgctg
     4021 ggcatcggct ttcgccgctg tcaccgcagc attcagctcc gtcagacgct cggcttcagc
     4081 tttacccacc acgccgtcct ggttcacttt caccagttca tcttccgcgg ctttctctgc
     4141 agactctgcg gcagccactt ttgcttcaac ctcggcagcc ttgtcatcag ccacgccatc
     4201 gtcgttcgca tccgtcaccg ccggtacctt gatcccgtcc agtttatcca gacgctcact
     4261 gaagcccgtc ttgaccggac catcctgcag accatccacc gcctgctggg catcggcttt
     4321 cgccgctgtc accgcagcat tcagctccgt cagacgctcg gcttcagctt tacccaccac
     4381 gccgtcctgg ttcactttca ccagttcatc ttccgcggct ttctctgcag actctgcggc
     4441 agccactttt gcttcaacct ctccagtctc ctgaccgcct tcaggctgaa ccggcttctg
     4501 ctcaccttca gctgtacgct tatgacgact gcttccacta ccgcctccgg cagccagtgc
     4561 aatagcagcc agccctgtac caaaagcaat ccccccccag ataatcccgt tattgatacc
     4621 tccagctaat gtgccacttt gccctgcagt aaaattctcc agtacagggc catcctgggt
     4681 caggacagct tcagttacct ggccattttc acccacaaca ttaaatactg ctgtacactg
     4741 tgtttcaccc ggctggcatt cttcccagaa tccttcaatc cggacttctg tactatcttc
     4801 ctttttacgt agaattaaat catcgcctga acggtcagct tccatcccat ccggaaccag
     4861 acctgtcacc tcatcaacca gtccatactg ttccccggcc tgtgccttta cggtatgacg
     4921 ggctccggct gccagtactg ttttttctcc actgaccttg ccagtgaaaa tcattttcat
     4981 ataagtatcc tcaggttaat aaaaccagta tgctcttatg ttttatccgc taaagggagt
     5041 cattaaataa aaacggatct agttacacat aattaatttg acgctttcta agcctcctca
     5101 atcattatgt ttttcagttt tattttcccc tgacaggaaa acatcttgtg ttatctttag
     5161 ctacagttca catacagcat gtgcaataac cctagcagaa taaaagtgaa attattccgc
     5221 tcatttaaaa caccttccct gtaagtgatt tttattatct ttcctgaagt gcctgcttca
     5281 ttctggttat cggtttaatc agatactgga atactgtttt acgcccggtt tttatatcta
     5341 cgctggctat cattccggga ataactggta atttttttcc attcctgtct gtaagataat
     5401 tattactggt ggtaaccaat acccgataat aagcttcatt agggtccagt tttaaatctc
     5461 ccggacgttt ctgatcacgt aaagtatccg gacttaccag tgttaccact ccgtcaagac
     5521 caccataaat ggcatagtca taagcagtca attttacaag tgctggcatc cctgttctga
     5581 cataggcaac atcccgtgga tttatataag cttcaatcag taactgatct tccagcggaa
     5641 taatttccat tatgtcctgt cctgcggaaa ccacccctcc cagtgtgttt acccgtatat
     5701 tttttacgat acctctcaga ggagccctga gacgtgaacg ctcaaccggg tcggctctgc
     5761 cagccatatt ctcttttgcc tgagcaaggt ctgtttctgt cttcaccagc tcagaaccgg
     5821 cttccgtcag gtatttattc tgtttctcgt ctatctgcaa ctgcagttca gctgactggc
     5881 gctgcatacg taacagttcg acttctgaca tcgccccttc acgtacaatt ggtcgtgtca
     5941 ttgctatttc cctgtccagc agagccttac tctgcttaag gccggcgatg ctctgcgcca
     6001 gctccgtctt ccggagaaaa tagaccgtac tttcccgctc ccgcaaatcc tcaggaacgt
     6061 tatccggaaa tgtcagtgat tcagaataag cttctgcacg gagtcttgcc ctgacggcct
     6121 ccaggttatt cacccgggct tcactttccc tcaacatggc tgagcttcgg gtatcatcca
     6181 gtgtcagcag cacctgacct ttatcaacaa tatcgccttc cctgacctca agtgttttca
     6241 gaatccccgg gtcaagagtc tgtataacct gctccctact accgggaata atacttccct
     6301 gaccacgggt cacttcatcc agagggctgt tccatgccca gataataaac gtcactacca
     6361 gtaccagcag aaaaatcacc atcaggaaaa gggcatgatg tttttcctgc tgaagggctg
     6421 cctgtacatc tgtcaacagc gccaggtctg actgcctaac cacttctgac gacgctttat
     6481 tccgttccat tttttctgtc atatccctgc ggtccacaaa ctgttaaaca tatctgctct
     6541 tttttcttat ccggttgagg ttcaggaagc tgccggtctg ttcccatcat tctgctgttt
     6601 ccctgacagt tttttcagta tttcatcacg ggaaccgtcc atcattaccc gcccttcatt
     6661 catcacgaca atacggtcaa caatattcag aacctgcaga cgatgtgtca ccaccaccat
     6721 tgtgcgtccc cgggtccagt ggctcagacc tttcagaaca acagactcag tctgcagatc
     6781 aaggcctgtc gtgggctcat caagcagtac cacccgggga gaactcagta ccattctcgt
     6841 cagggcaacc atctgcctct gtcctcctga cagccccaga ccaccttccc ctatctgcat
     6901 atcaagtccg cgaggatgat gtcggataaa acggtcaaac ccgaaacgtc cggctgcatt
     6961 aatcatatcc acatccgaca ggcttcccgg tagacgcgaa agctgcagat tttcacgcag
     7021 agttcccaga aaaagccggg gattctgttc aagaagaaat actttgtctc ggacaaaact
     7081 gggatccagt tgctgcaggg caacaccgtc aagagtaatt tgtcccctgt tctgacggta
     7141 cagtcccacc atcattttca gtagcgtcga tttgccacac cctattgcgc caataatacc
     7201 cacccgctct ccaggtcgga tactgagtga cagaccggac aatgcctcgg gtaatccgga
     7261 cttataagaa aaggagacat cactgaaacg aaactctccc tggatatcct tcactgtcag
     7321 ataatgtgtc tgacgttccc gctccaccgg acggcggaca atttcattca ccccctgcat
     7381 ggccaagcgg gcctgctgaa aacgggtggc cagtgatgca atctgaccaa gtggtgccag
     7441 cgcacgaccg gaaagaataa ccgcggcaat cagtgccccc atggtgattc ggttatgtgg
     7501 gtcatcatta tgaataagat aagttcccag aataaccagc agaacagtat tcagttgctg
     7561 aactgctatg gaaaaacaga taatgacatt actggtattt tttacccgga tggacgagcg
     7621 ggcgacactg gcagtatatc catcccagcg acgctggacc cagttaaccg cattattcag
     7681 cttcagagtt tctattccgt ccagtgcctc cacaagtaat ccctggcgct gcgatgattc
     7741 ccgcatggag gcatttatat gacgggaaag cggtcgctgc agtaatatcc ctgccagaat
     7801 caccagtgga accagtgtaa gaggaacaac agcaagccag ccccccacaa gtccgatgac
     7861 accgatgaaa agcaggataa aaggcaaatc cacaaaagcc agcaacgtgg cactggtcat
     7921 aaactcccta acagactcat attcccgcaa attgctggcg tatgaaccgg aggatgctgg
     7981 tctgtccgac attttcaccg ccatcacccg gcgtagcagg gcagagctga taatcaggtc
     8041 tgccttctta cccgcaatat ccgtcagata gctccgaatt aattttgcag cacattcaaa
     8101 cagaatggct gcaatcactc cgatactcag catccataac gtttcccagg atcgattagg
     8161 tatgacccgg tcataaacgt tcattacata taaggagcta accagtgcaa gaaaattaat
     8221 gataaaactt gcaagaataa cctgtccgta atatggcctg aagcgccaca gaacccgcca
     8281 gaaccatccc ccgctcatgt catactccgg caggtccgaa cgacgatcct gtgttgcctg
     8341 tggctgaaca aaccagcagt aaccagaata aacagccatt aacgcttcat gagacagttt
     8401 attacggagc ccaccgggct gaagcacatg atactcccga gtcagacctg tacccctaat
     8461 acgtacaaca acaattgctt cctgagcatt cagtaaaaga agcactggaa ccgcaagtga
     8521 aggaatatcc tccagagccc gcctggaaag atgattatca aacccttcgc tacggagaaa
     8581 ttcgccaaca gaacgaaaat caatccccga tacatctgtc cggacagtac tggcagccaa
     8641 agcctcagca gatacaggtg tacccagtaa tgccgttacc tgtgataatc cttcaaaaat
     8701 actcttcact tatttacctg cccttcagcc ccgttatttt ttgcatcaga aagattcact
     8761 ccgctccatt tcaggagcat tccctgggaa tagagataat ccagcattcc gtggagcatc
     8821 tgatcctctg tctgaacccg ggaaagcccg acactgtaca gttcattttc tgcattaagt
     8881 aattcaatca gtgtttttct tgccacacga aactgaagac gataaaagtc tacaactttg
     8941 gcagaggcct gttcctgacg tctgagcgtt tccatttcca cccgactttc tctgaccgtt
     9001 atcagagata atcgcccggt ttcatcaatc agtcgggcaa cagagtcccg tcggcccgta
     9061 gctgcggcta tctgcgcagc tttttcactg acaccgtaac tggcattacg gttaaaaagg
     9121 tcccaagaca gattgacacc tatctgccgg tcatcttggg ttacagagcc cgttaaatct
     9181 atccggggat accgggcaag ttcctgagct ctcagcgccg cctttttact ctcaacatca
     9241 gcctgactag caagccacga tggatttcct gtctgaggtg cctgtgtaaa atcagttaac
     9301 aatctggact ctgtcatcag agaaaaagga ttttcaagat cggcttcggt taccggattt
     9361 attgtccaag tcgaaagttt tcccagtgta cttttaagca ctctgttccg agtattaagc
     9421 tgctgccgga tcattaatct gcgtgcatct gcctgtacaa attcagattc ccgccctgta
     9481 tcgtgaatac tgattgtatt aagatcatta agtatcgagt tatgtcggga aagactctgt
     9541 ttaagtacct caatggattg tttttccctg agtgcatcaa gatatagaga tacaaaggaa
     9601 cgaattcttt cttcccctgt ttctttcact ttataataat aatactctgc ttctgattca
     9661 ctccgacgta catccgcctc aattgctcct gaagcgaaaa tattcacttc accacgaata
     9721 ccaggcaaaa tatcttcaga gtcataatca taagaataac ggtgactctg tgaaaggagt
     9781 ttacttcccg tagcagtgat aaccggccaa tgtgcagaac gagcctgctc tgtgcgggat
     9841 tgtgcagaat ttaactcggc tcgggcctcc ataacagctg gatcattcat tacggcctcc
     9901 ctaaccaaag aataaaacgg tgcactaatt gttgaacatg aaagtaacaa caacgagaac
     9961 aataaatttt tcatctctta tgttcttgtt aacactctag atagttagcg taattactag
    10021 aatgaactgc gctagaaatc accatgataa tattcactaa gtaatgctga gatattattt
    10081 atataagata gtttctttaa ggtgacagaa aaatagctga gtgacacact gttcttttcg
    10141 cacgcttctt ttttggaaaa accatcaacc aaatagtctt ttaaagacat gatgattttt
    10201 tcactgcgaa cacctgataa ttctattagc aaccaaaagt gctcattaca aatattagcc
    10261 gcagttaatt taacactaca tctataacag gagagcgtgt gccgtaatat atgctcatcg
    10321 agtttcataa acataccatt aaaaatgtca atatttagtg gtttattgat ttatattata
    10381 aatacgtatt aatttgtatc aatttatttt tgctattaat caaaaacacc aacactaggg
    10441 aaaatcacaa taaaaaccaa aaaacaacat aaaaaaccaa aaaaaacaac aaaaacaacc
    10501 ttataacctt taataacaaa aaaaacaaaa tataaaacta ataaaaacaa ttattgaaag
    10561 tgagtttttt tgttaaaagt caatttttag tgtagaaatt atctatataa tagataattt
    10621 aaaaatcaca tcaggaaatt tttgtcatat tcatgttcct attttattat atttttgtta
    10681 agaaatatcg gtgatcacct gacgatatga ttcaattcat tgagcaatgc gaggtggctt
    10741 tcgctttcat ttttatcttc gattggttaa ctgcttccgc cagtgtcatt acgcttatga
    10801 ttcctaccaa tgatcctacc cgccaatagt ggacacggga ctaagtgagt acactttcaa
    10861 tcagaggtga ctcatgacta aaccagtatc agccagcaaa aagccccgta agcaacactc
    10921 gcctgaattt cgcaatgaag ccctgaagct tgcagaacgc atcggtgttg ctgccgctgc
    10981 acgcgagctc aacctgtatt aatctcagct ttatgcctgg cgtagcaagc tgaaaaattc
    11041 acattcctct tgcaaacgtg agcaagacat gtctgttgaa attgcccgtc ttaagcgaca
    11101 actggcggaa cgggacgagg aattggcctc cctccaaaag gccgcgacat acttcgcgaa
    11161 gcgcctgaaa tgaagtatgt ctttatcgaa aaacatcggg ctgagttcag cgtcaaagcc
    11221 atgtgccgtg tacttcgggt tgcccgcagc cgctggtatg ccgagctcct gcgtcgccat
    11281 caaataagcc cgcgccagca gttccggctc atctgtgatg ctgctgtccg taaagcattc
    11341 actgaggcaa aacaacgtta tggtgcgcct cgtcttgctg acgaattgcc ggaatacaac
    11401 atcaaaacaa ttgctgccag cctgcgtcgt cagggactac gagcgaaagc gacccgcaag
    11461 ttctgtccgg tcagttaccg tgagcacggc ttgcccgtgt cagagaatct gcagaaacag
    11521 gatttttacg ccagcggcca aaccagaagt ggacaggtga catcacctac ttacgtacgg
    11581 atgaaggctg gctgtatctg gcggtgatgc ttgatctgtg gtcgcgagcc gtcattggct
    11641 ggtcgatgtc gccgcgtatg acggcacaac ttgcctgcga tgcactgcaa atggcgctct
    11701 ggcggcgtaa acatccggaa gatgtcattg ttcactccgg acgtagtggc cagtactgtt
    11761 cagcggatta tcagaccttg ctgaaacgta ataatctgcg ggggagcatg agtgcaaagg
    11821 gctgctgcta tgacaatgac tgtgtggaaa gattctttta ctcgttgaaa gtggactgta
    11881 tccacggaga acgctttgcc agccgagaaa taatgcggac gacagtgtta attatatcga
    11941 gtgtgattac aatcgctggc gtcgccacaa tgcgtgcggc ggtctcagcc cggaacaatt
    12001 tgaaaaccag aatctcactt agcactgtgt ccacattccg tgggtaagat caatttttca
    12061 actgtcgcaa ctactggccg cagtggtttg ggtaaagtga ctccagcagt gattcatgct
    12121 tggctcaatg ttgtaaagca acttagtcgg aaatacgaat aaaagataat aatcaccagc
    12181 aataaatcca atcagcaaaa gttattaggc agtccctata ccatgttatc ggagagctgc
    12241 ccacgtatgg ttatcgtcag gtatgggcgc tgctttgcag acaggccgaa cttgatggta
    12301 tgcctgcgat caatgccaaa cgtgtttacc ggatcatgcg ccagaatgcg ctgttgcttg
    12361 agcgaaaaac cgctgtaccg ccatcgaaac gggcacatac cgcagagtgg ctgtgaaaga
    12421 aagtaatcag cgatggtgct ctgacgggtt cgagttccgc tgtgataacg gagaaaaact
    12481 gcgagtcacg ttcgcgctgg actgcgtcca ccatatttgg tgtccactat tctctcagga
    12541 atttcaggat ctgccagacg gtgctgagac gacgcttact gttcaccaga aagtttcatc
    12601 cattttcttc cacccaagtt gcggaagaac cacttttttg caccgttcgt gacatcaata
    12661 cggccctcgc tgtacgctta cgtctctatc atatgatttt tctttgtttg ataattaatt
    12721 atcgaataat tgaagtgtta ttttattgtt attggaaata gataaaaaaa taaaatgcgg
    12781 ttgttttttt attgaatttg catcttatga agctctagta ttgaagatat atagaactgt
    12841 tagaaaagtt aaatattcgt attgcggatg cagggagaat aatgtttaag gctattttta
    12901 ctgttggcag tcttctttta ccctgtattg ttgtagcaaa aggtattggg gtaacggctt
    12961 catctaatga tgttgtagat gcgcagcttt ttagtgttga tttgaatttg aatcgtgtgg
    13021 tttattatca tggttcacta ggtgaaaatg tagcggtaaa aaataatcag gcatatccta
    13081 tgcttgttca atcaatggtt tttgatgagg ataaaaagtc atcagcgcca tttattacta
    13141 ctccacctct tttcagatta gatgggagcc agacgagtag gattcgtatt gtaagaacag
    13201 ggggagagtt tcctcaagac agagaaaaat tacagtggtt atgtgttaaa ggaattccac
    13261 ctcagagcga ggataaatgg gcagaaggta caatcactaa aaattcatca tttactgtac
    13321 aattttctgt gaataattgt atcaaggtat ttgttcgtcc agacacaatt aaaggtcacc
    13381 cagaagactt tgcagataaa gtgacatggt caaaaaaagg tactactgtt ctggaagcaa
    13441 ataacccaac tcccttctac cttaacatta aggagttaaa tattggggga aggagtatta
    13501 aatcgcctaa ttatatacct ccttttggaa aacaaagctt tagtattcca ggttcttcag
    13561 ttggtaagat tcagtggaga atagtaactg attatggtgg agatagtaag atctaccaat
    13621 cagaaggaaa gtgattctgc tgcatggtaa gtgagttgaa atggaagaaa gaaataataa
    13681 atacgaactg tctgcgctgt atatcgctgt tctttcatca ttgcctttct ttttttgtgc
    13741 agatgttgcg gccagaagct acacattcga gccatctatg ttgaatgtag atgggaatga
    13801 tattgatctt tctatatttg aaagtggcgc tcaattaccg ggtacttact atgttgatat
    13861 tatgcttaat ggtaagttgg tagatacaaa ggaaatggag ttttctcgtg agcgtaataa
    13921 agacggagag tttgttcttt cttcatgtct tactcagagt atgttgaatc gttatggggt
    13981 ttaaggtagg agactaccca gaactttttg ttaatagttc taatggtaag gtatgtggtg
    14041 atttgtctgt tattcctggt gcattctcat attttgactt ttacaatcaa caactgaatt
    14101 taagtatacc gaatgtagca ctatatccaa aatataaagg cattgcatca gaagagcttt
    14161 gggataatgg aattaatgca tttctgatga attaccaagc taatgcacaa ataaaccaat
    14221 atcgtaacaa aaaaatcgag aagtcagttc ttattgggcc aggatcgagc ctggtatgaa
    14281 tattggttct tggcgcataa gaaacttgac aacttttact aaagaaaatg gtaattctga
    14341 aaaaagagaa agcgtttaca catatgctga acgtggtctc acatccataa aaagcaatct
    14401 gctgataggt gagtcctata ctaactctga tatatttgac agcatatctt tcagggggat
    14461 aatgctccat tcagatgaga gtatggttcc ttatagcaag tatgcttttg cacctgtaat
    14521 cagaggtatt gcacagtctc aggctttgat tgaggttcgg cagaatggtt atctcattca
    14581 tactgttagt gtggctccgg gggcttttga aatctctgac ctacctgtca caggctcagg
    14641 tggtgattta caagtttccg ttatagaaac aaatggtaaa accagtcttt caccgtccct
    14701 tacactacac ctgtgattgc tttgcgggaa aactatctga aatatagctt ggttggcggt
    14761 atgtatcgtt cggcttattc tggtgtggac aatactgctt tgattcagat gacagcaatg
    14821 tatggtatgc catggaatct gacaacattt gtaggattcc aaggctctga acattacaat
    14881 tctgtcgcaa caggtgtcgg attgtctatg ggggatatgg gggccgtatc gcttgatgga
    14941 atatatgctc gaggacagaa agaaaacaga ataaagaaga tggatattca tggagagtaa
    15001 gatacagtaa ggtatttgat ataacaggaa ctaattttat tgctgctagt catcagtact
    15061 cttctgatgg ttatcagact ctttctgatg tacttgatac ttatggccat agcaattact
    15121 cctacggagg ttatgctaat cgctctatgc ggaatagtct gacaataagt cagtccaatg
    15181 ggggaatggg ggacctttag ttttgggggg ttagggatga atatagagga aatagatcgc
    15241 cacagaattc tataaatgcg ttatatagca atagtatgga atggggaaac attgtctctt
    15301 aactggagtc agaatagata actgactctt cgagaagagt gaaagataag aaagaaaata
    15361 tcttcagctt ttgggtgagt attcctctat acagattact tggaaatacg tctaacaata
    15421 taaatgcaac aacacagata cagaaatatg ataaccaaaa aatgcagtat gaatttggta
    15481 tgaatggtcg tgcattcaac aggcagttgt actgggacat tagtcaacga ttggcaacca
    15541 ggaaacgaaa attataatga tgccagcaga ttaaaccttg agtggtatgg tacttatggt
    15601 cagattcgag gcggatacgg ttacagcgat tctctcagac agatgaacgc aggaatatca
    15661 ggaaccgcca tcgttcacag taatggagtt acgtttggac agaaacaggg tgggactatt
    15721 gcccttgttg aggcgcaggg ggtagatgga gcggaagtta ttggatgggc ctggtgttaa
    15781 aacagacttc agaggttata cagcattggg ccatcttaca ccatatcagg aaaacactgt
    15841 ttcattgaac cccgcttctt tccctgaata tgcagaagta ttgcagacag atacaaaagt
    15901 tataccatac aaaaggtgcg gtggtttcgg caaggttaaa acatctattg gtaaaaaggc
    15961 gttgtttaag ttaacaagac acgatgggaa aaaagttcct tttggtgctg tggtttcatc
    16021 agcaacggca gatgataata agcgcgttgt agggattgta aatgagtcag gtgaagtgta
    16081 tatgtcaggc ctgtctgaaa aaaggacaac tggatgtgaa atggaacagt catggaagct
    16141 gtaagggcag tttataagct ttctgataat aaaagcattg ttaatatata ataatgcatc
    16201 cttgacttgt atataaaacg gaaagtatta tatggtactt aaggcttact ttcttttttc
    16261 ttgtttgttc ttcaacggtt atcgctacct gaaattaatc ttgagacaag ggcattttca
    16321 ggtagttatt tatattatgg tgatattatc gctaccggaa gtgtattttg caatgatggc
    16381 gaagtatcta gagtggtcct tttaaatata aaacctgtaa aatggttctc agagtaatgt
    16441 atatcatcta cagggaagaa ataagccttc aaatgaattg actgttagga tagaaggtaa
    16501 cggatggagt ccttcagata aagtcgggaa tggcaattta taaaaaaact gattaataaa
    16561 caagatcagt tttattggtg gctaatggtc gtcagcatgt gagagctgat atctacacaa
    16621 tcagagcagt tctatatgct ctagattata actaattaga gtattaggaa acaaagagaa
    16681 taatctttgt taaagtaaat aataacatgt tgcattattg tacatgtgtt tgatattgtg
    16741 tttttaatcc tttaaaggtg tttaacatga aaaaagaaac ttattgcagc tgcagttctg
    16801 tttatgacgg ctaacatggc gaatgctgca actctggata atacatcttc cgtaaaagct
    16861 gactttgagg ttgtcggtgg ttgcactgtc tctggaacat ggactgtgag caagtccctg
    16921 ctgctgtata tcatagctca actaggcgtg taggtgtact tggtatttcg ttgtctggtt
    16981 gcactagcca agtttatttc gaagggaacg ataaaaactc agacggactg cctcaagcca
    17041 ctgatcctaa gggtaataaa ataactatta ttccatcatt caatgcatta aatactcttg
    17101 tgactaaaga cgctacactt aatgtgttct atagcaaaaa ttccctgaat gatggtgaca
    17161 ctctttctgt tgaattcgtt aaccgtgatc agtggaatgc taaagctggt aaacatacta
    17221 tgactcttaa tgtaggtact tactctatct aatacagtta gtccccggca tagcgccggg
    17281 ggcattattg tgcacagaaa acccccagcc aggctgtaat gccagtcagt taagcaactg
    17341 actggctctt tttcggggct gtggggtata ttggtaacgt tattagttac agtaatattt
    17401 ttgtattgta tgtttgatgg cgtcaggtat cttttaaaga tttatgaaaa atatgacgat
    17461 gtaccaacat ctcttacttt agtgggttta gggatcaaat tgaggcaaaa acagtatgac
    17521 cactgagggt gaaaagattg acagtatagc attaccttcg attgcagatc ctaaggctgt
    17581 tgtgtggcta ggggacaaca cattcggtat aggtagcgag ggcgatggct ctgtaatctg
    17641 ataagtatag atatatataa gagagcttat aatataatat ctaagattat gtttagtgag
    17701 tatacaaatc ctgttaataa ggggttggaa ggattgacat gggatggaaa taatcagaat
    17761 ctgtttgcag caaaggagat gaaagatgtc acaattacca gagctaatat gataagtaat
    17821 gacatgggaa ttgacaaaat catcgatccg gtcgccaagt ctttaaagga tgtatcagga
    17881 ttgcattatc atacaccaac atcttcgctt taattctttc tcatgaatcc ccaaaaatta
    17941 tagaggttaa taatgagggt agaattacag atagattgta tctggagtct ggttggtccg
    18001 gtttgacaga aagtgtcccg caggccgaag ggataactct agattataat ggttacttgt
    18061 atatagtgag tgaaccgaat ttgttctatc gttttgcgaa ataatagagc aaaaaacaat
    18121 ggggactgaa ttgctttgtt gctccaggat attctcaact gaactgattg aaattatgtc
    18181 aagtctagtc aggtggtaca tactgatcga gtaggaggcg ggatcactcc cgccgtcctc
    18241 tcacaccacc gtacatgcgg ctccgcatac ggcggttcat gttaacactg gaactgcctc
    18301 tgctgttcca gcagtgatat cagaccctgc ctgctgaacc acgcattctt tatcgcctga
    18361 ttcatatggc ttgaccctga gttccaccat ggcccgtggt tgttgtacgc tgagatcatc
    18421 gcactgtcct tactcagccc cgctctttgc aggttcttcg tccgggttcc cggcctcttc
    18481 cactgccgcc acaacaggca ccgcagtttc cgtttgatcc agccgtccag ctcttccagc
    18541 actcctctga cttccgtcag cctgaagtag cttatccatc cacgcagcac tggcatcagg
    18601 gcattgattg tcgctttcac tgatttgctc cggtttcccg tggtcagact gcggactttc
    18661 tccttcagcc tgttcacgct cgtcagggct attttcagct tcgcctgttt gtgccatgtc
    18721 acactgtacc cgaggaactt ccgctcccac gggcgcgcca ccgcgctctt cttctcattc
    18781 accttcagtt tcagtttgtt ctccacgaac gccctgatgt tcttcagcag atgctcgccc
    18841 gctttccggc tgcttaggta gatgttgcag tcgtctgcgt agcggcagaa gctgtgtcca
    18901 cgacgctcca gttctttatc cagttcatcc agcaggatgt tcgacagtaa cggcgacagc
    18961 gggccgccct gcggcatgcc ctcctgccgt ttctcccttt gcccgtcccg gactatttcc
    19021 gctttcaggt agcggcgtat cagtctcagc acccgcctgt cctttatcgt tctggccaga
    19081 cgcgtcatca ggagtctgtg atccacccgg tcaaagaact tctccagatc catatccacc
    19141 acccaccgtt tgccgccccg tatgtaacgc tgtgcctgtt gcaccgcctg ccatgcgttg
    19201 cgccccggcc ggaagccgta gctggagtct gagaagcttt tgtccacgat ggcgcttaac
    19261 tgctgcgcta tcgcctgctg gataagcctg tccaccaccg tcgggatgcc taaggttctc
    19321 acgccgccat ccggcttcgg gatatccatc cggcgtattg cccgcggctg gtagtttccg
    19381 tcaatcaatg cctgcctgac actgcgccag ttcttcttca gccacggttt caactccgcc
    19441 acgctgaggt tatccacccc cgccgcgcct ttgttttcca ccacgcgctg ataagccagc
    19501 atcaggtttt ctctcgttat caccgcttcc atcgtcagcg gcacttccgc tttcgtttgc
    19561 ccacccgccg ccgtgctgat ttcagcgcca tcatgcagcc ctgacggata ccgtccgtct
    19621 cctctgccgc tggccgcagt tgcctgcgct tgtgcttcat taatcatcat cgggttcgga
    19681 tgtcctaatc acggttaatc atgttcggcc cttcatgctg ccggttttgc agcactacta
    19741 cggcgtcggc tgacttctgc cgccccatcc tggcacctta cgatgccggt agcacactgg
    19801 caggacggca gatctcccgg ggtaattcgc gcgactttcc tgcttatgcc tgtcggctct
    19861 acgtcacagc gttccgtgtg agtatcgggc tttggtgatg tatgccacct taccccgctg
    19921 cgccgcctta accgcttcct gttcgtcagg ccagcatttt gcatccggct tccttcagat
    19981 ttcacctcgc gatgaacacc cttgccttcc gctaacactt cccctcaccg gtgtgtggag
    20041 gactttcacc tcttagtcgt tcttcagcca ccacagttga agaacagcgc cagtcacggc
    20101 gctacgcgcc atgcccggcg cacatagcat aaatagagat attgtattaa tatctctatt
    20161 tgtgtttttt tgagtttttt ctaaaatttg tctatattag aaagctattc ttatttacta
    20221 gagaaatcaa gatgatttat gataaaaata aaacttcttt ggtgtgacac cataatagct
    20281 attaaacaat tttatgaagt atgatgtgct ggacattcct ataagcttag aaacattatt
    20341 tatgtgattc ttgctgttga gtattaattt tgctgcataa ttcatctttg aatctagcaa
    20401 aacttgttgg aaagtaatgt tctcattctc gagatttttc cttactgcta cctctgacat
    20461 gttcatttct tcagaaatat cagaaagctt ccactttttt tcaaagtcac actcaattat
    20521 ctttttgact ttatcagtga aactgatgga tgttgataca catattgatg aaaaaaaatc
    20581 acactcgtta tcaataatcg agaaaagaca cgctagtttg tatactttct cattacatac
    20641 tttcattgat tttatacttt tgaatatctc agtggaaatt atgtccccat ctatcatgaa
    20701 tattctctgc tgtaatcttc tttttctttg catctgtcca aaactaaacg aataaatagg
    20761 gtccattata gttaatactt tagataaaag atcattattt atgcttatga cctcaaatgg
    20821 attcgtttcg gtattcgttc tttttattat tgagatgttt atttctatat gcttttcaaa
    20881 aaaagcaatg catccttctt ttattgtaag gtgttcatta ccgtatgtaa catgtagcgt
    20941 acatttattt gtgtacacaa tcgtatattc atataatcta acttttaggt gtgatttgta
    21001 tttgttcgta tattccataa tcgatattga tattattctg atttacggag ttttcattct
    21061 agtatagata aaaaataatg gatagcagtg ttagtttatt atcatattgt gttgtttgtt
    21121 tttcattttt ttatcttttt agtgtttgtt tgtgattttt actcccgatt tttcgtacca
    21181 agtagttatt aagcacgtaa gcgtacagcc tgaaccgtct ggtcagaatc tgacgaatta
    21241 gacaaagtgg tgtccaccaa ataagtgatc tgcgccccaa atcttggaca tcctatgaaa
    21301 aatgtttaag tcgatattga accggactca tgccatcgag tttctcttta atgcgatggt
    21361 gattgtagta ttcaatgtaa tcaattatat cttgctttag atgatgtaac ttattgtatt
    21421 tatttagata gtaacattat gattttaaag tactaaaaaa gctttccatt gctgcattat
    21481 ctaagcagtt accacgtcgg gacatgcttt gtgttatgcc attatcactc aaccaacgtt
    21541 gccaacgagg catctgatat tgccacccct gatcactatg caacaagggc ttatcgtctt
    21601 tattgagttg ttctaccgca tctaatagca tgctctttac cattgatgct aatgggcgct
    21661 cagtaaggtt atatgagact atttctccat tatacaggtc catgattggt gataaataga
    21721 gcttcctgcc atcgacctta aactctgtga catctgttac cagtaattgt gataatggat
    21781 gacattgcct taactcatta ataatgatta ctttttcttt tgttccaatc gtaatttttc
    21841 ctgagctaag gctttcagct tttttagata agcgttctca actctcagaa actcaagttc
    21901 ttcccgttca ctgattgtca gttgtgtcga acgatttcgt tgataaacag caggagtttt
    21961 cggcctcaaa tcttcctttt gtcccttcat cgaaaaatca acctcactgt attttttaat
    22021 ccatttggat atggtgttaa aagcagggat cccatacttc actgcagctt cccttataga
    22081 aagagaatta tcaataacat ctctgactac attcaatctg aagttatcgt cataacgtcc
    22141 tttttgccca gtcagtgttt ttaatccgtg cttacggtaa acataagccc atttccttac
    22201 cgtgctgggg tcaatattgt acatttttcc aacagacttc aaactcagct caccttccag
    22261 gtatttttcg gatacttccc ttttgaattc taatgaaaat ttgctcatac gctcctcagt
    22321 tacagatctg gtgtctaact attggggcgc acttcataag tagtgggaac caatgatctt
    22381 acccaccaat agtggacaca ggactaagtg agtaaactct caaccagagg taactcatga
    22441 caaaaccagt atcaatcagc aagaagcccc gtaaccaaca tacgcctgaa tttcgtaacg
    22501 aagccctgaa actcgctgaa cgcatcggtg tggccgccgc agcccgtgaa ctcagcctgt
    22561 atgaatctca gctttatgcc aggcgcagta aacagcagca acaaatgagt tcgtcagagc
    22621 gcgaaagcga actggccgct gaaaatgtcc gccttaaacg acaactggcg gagcaggctg
    22681 aggaactggc catcctccaa aaggccgcga catacttcgc gaagcgcctg aaatgaagta
    22741 tgtcttcatc gaaaatcatc gggcagagtt cagcatcaaa gcgatgtgtc gtgtacttcg
    22801 ggttgcccgc agcggctggt atgtctggct caggcgtcgt caccagatga gcctgcgcca
    22861 acagtttcgg ctcacctgcg atgccgctgt ccataaggca ttctttgagg caaagcagcg
    22921 atacggtgct ccccgccttg ctgacgaact gccggagttc aatattaaaa ccattgccgc
    22981 cagcctgcgt cgtcaggggc tgcgggcgaa agcctgccgg aagttcagcc cggtcagcta
    23041 ccgtgcacat ggcctgcccg tattggagaa tctgctggag caggactact cagcgccagt
    23101 ggcccgaaac cagaagtggg cgggtgacat cacgtacttg cgtaccgatg agggctggtt
    23161 gtatctcgca gtagtcatcg acctgaggtc acgcgccgtc attggctggt cgatgtcacc
    23221 gcgaatgaca gcacaactgg cctgtgatgc actgcaaatg gcgttgtggc ggagaagacg
    23281 cccggaaagc gtcattgttc atacggaccg tggtggtcaa tactgttcag gggattatca
    23341 ggcgctgctg aagcgacaca acctgcgtgg cagtatgagt gcgaaaggct actgttatga
    23401 caatgcctgt gtggaaagct tctttcattc gctgaaggtg gaatgtatcc acggggaacg
    23461 ctttagcagc caggaaataa tgcgggcaac ggtgtttaat tatatcgaga gtgattacaa
    23521 tcgctggcgt cgtcacagtg cctgtggcgg tctcagcccg gaacaatttg aaaaccataa
    23581 tcttgcttag agccgtgtcc acattacgtg ggtaggatca attttaccgc tgctggtccc
    23641 tcattcagtg actgccccag ggttttttca tgctctcctt atagtataat aatttccata
    23701 tccaaactcc cccctacttt aacttttatc atagtcaaaa cctcttaacg tgagtttttg
    23761 ttccactgag cgtcagccct ctaaaactac tgaataatca gttagaaaac aaacaatcgg
    23821 aaaaatctgg ggttccggcc tagaacccca tgaacaggca tagctgtgat ttcattgaat
    23881 tattggcaca aatcagttga tcgtacaatg ctgtgcctgt ctcgttttct ggagattcct
    23941 cagcctcatg gagcggcgta acaggcgtac cggcaggaca gagatgtttg cttttcctag
    24001 tccggccagt ttagtggaat aacggagttt ttatcccatg ttttttcccc cgatcacgac
    24061 tttttcaaat caatgctcag aatacgttct ttagctcctt ccacaaacac atcaggatcc
    24121 caatcgcggt taaagccttc tttgatgcca atgtaaaggg tatccatatc gtccgacaac
    24181 accatctggt ttgggtaaac cggcatgtta aattcacggg tgatgctgta tttggtggca
    24241 tccactacgc tgatggtgcc gctagtgaag ttggtgacat acagttcgtt atatttcgga
    24301 ttgtatttca ccgcgttagc tccggctcct gtgtgcacat agccaagctg tttaccgtcg
    24361 cgtaagtcaa aaatatagag tccatctttt gtaccggaac gatcgtcatg gtcgaatacc
    24421 accacaaagg cacggtcaga agcggagtcc accgccagat tctgcacact tgtgatttgt
    24481 ggtctcggat ctttcaacgg gatggtacgc agcagcgtct gatttttcgc atcaatttcg
    24541 ttgatgtaat ctcttccgcc aacgtagatt ttctgtgttt tttcatccat cgtcagacca
    24601 tacgctgtac ctttgtaagc atccttaacc tcgcctttta aggcaagcgt cgtcccgtcg
    24661 agcattaaca gcttatgcag aggcttcatg ccctcggccg ttttcagcat attgctataa
    24721 ctcacaaaca gggtatcgga atcctggctg taaaccatat ggcgcaaatg ctcaaaacgc
    24781 gaatctgcag cgtttgccgc tttaaaactt aacctgtcgc tggttcttac cagtttgccg
    24841 gttggggtgt caaacatact gatacgcagg gacgctgact gggtgtgtcc gatatagagc
    24901 tgatgtttat cctgatttat cgccagcgaa aatgcccggt atggcatcgt gtatttattt
    24961 tcgactttca gcgaatctga attaaacgaa tacagatagc ctttattggc ttcacgattt
    25021 acacgatcag tgactgctgc aaacaccttt ttactggcat tatcaaacgc cagttcatag
    25081 acgccttcat caggggactg aaggtaattc gttttcaggg caaatcgcga aagttcgcgt
    25141 tcaggtggat cgatagccat ggccatcgtg ggtaaaaata gtgaaattaa caggtatagc
    25201 ggtgctttgg ataagtgaaa atattcattt ttcgttcctg caataaaatt gacataagag
    25261 agaaaacgta ttgtctgaac ctagcggaaa ttgtcatcag aaacgaatgt ccccgcaaat
    25321 atccatgttc tgccacgcgc ggaattggc
//
